-- dump date 20120504_151729 -- class Genbank::misc_feature -- table misc_feature_note -- id note 881621000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 881621000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 881621000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621000004 Walker A motif; other site 881621000005 ATP binding site [chemical binding]; other site 881621000006 Walker B motif; other site 881621000007 arginine finger; other site 881621000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 881621000009 DnaA box-binding interface [nucleotide binding]; other site 881621000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 881621000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 881621000012 putative DNA binding surface [nucleotide binding]; other site 881621000013 dimer interface [polypeptide binding]; other site 881621000014 beta-clamp/clamp loader binding surface; other site 881621000015 beta-clamp/translesion DNA polymerase binding surface; other site 881621000016 similar to unknown protein, C-terminal part 881621000017 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 881621000018 recombination protein F; Reviewed; Region: recF; PRK00064 881621000019 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 881621000020 Walker A/P-loop; other site 881621000021 ATP binding site [chemical binding]; other site 881621000022 Q-loop/lid; other site 881621000023 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621000024 ABC transporter signature motif; other site 881621000025 Walker B; other site 881621000026 D-loop; other site 881621000027 H-loop/switch region; other site 881621000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 881621000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621000030 Mg2+ binding site [ion binding]; other site 881621000031 G-X-G motif; other site 881621000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 881621000033 anchoring element; other site 881621000034 dimer interface [polypeptide binding]; other site 881621000035 ATP binding site [chemical binding]; other site 881621000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 881621000037 active site 881621000038 putative metal-binding site [ion binding]; other site 881621000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 881621000040 DNA gyrase subunit A; Validated; Region: PRK05560 881621000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 881621000042 CAP-like domain; other site 881621000043 active site 881621000044 primary dimer interface [polypeptide binding]; other site 881621000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 881621000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 881621000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 881621000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 881621000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 881621000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 881621000051 cardiolipin synthetase; Reviewed; Region: PRK12452 881621000052 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 881621000053 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 881621000054 putative active site [active] 881621000055 catalytic site [active] 881621000056 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 881621000057 putative active site [active] 881621000058 catalytic site [active] 881621000059 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 881621000060 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 881621000061 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 881621000062 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 881621000063 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 881621000064 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 881621000065 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 881621000066 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 881621000067 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 881621000068 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 881621000069 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 881621000070 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 881621000071 D-pathway; other site 881621000072 Putative ubiquinol binding site [chemical binding]; other site 881621000073 Low-spin heme (heme b) binding site [chemical binding]; other site 881621000074 Putative water exit pathway; other site 881621000075 Binuclear center (heme o3/CuB) [ion binding]; other site 881621000076 K-pathway; other site 881621000077 Putative proton exit pathway; other site 881621000078 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 881621000079 Subunit I/III interface [polypeptide binding]; other site 881621000080 Subunit III/IV interface [polypeptide binding]; other site 881621000081 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 881621000082 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 881621000083 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 881621000084 Bacterial SH3 domain; Region: SH3_3; cl02551 881621000085 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 881621000086 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 881621000087 putative active site [active] 881621000088 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 881621000089 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 881621000090 active site turn [active] 881621000091 phosphorylation site [posttranslational modification] 881621000092 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 881621000093 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 881621000094 HPr interaction site; other site 881621000095 glycerol kinase (GK) interaction site [polypeptide binding]; other site 881621000096 active site 881621000097 phosphorylation site [posttranslational modification] 881621000098 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 881621000099 putative dimer interface [polypeptide binding]; other site 881621000100 catalytic triad [active] 881621000101 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621000102 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621000103 Walker A/P-loop; other site 881621000104 ATP binding site [chemical binding]; other site 881621000105 Q-loop/lid; other site 881621000106 ABC transporter signature motif; other site 881621000107 Walker B; other site 881621000108 D-loop; other site 881621000109 H-loop/switch region; other site 881621000110 Protein of unknown function (DUF2705); Region: DUF2705; pfam10920 881621000111 Protein of unknown function (DUF2712); Region: DUF2712; pfam10916 881621000112 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 881621000113 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621000114 active site 881621000115 motif I; other site 881621000116 motif II; other site 881621000117 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621000118 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621000119 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621000120 DNA binding site [nucleotide binding] 881621000121 domain linker motif; other site 881621000122 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 881621000123 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 881621000124 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 881621000125 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 881621000126 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 881621000127 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 881621000128 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 881621000129 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 881621000130 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 881621000131 dimer interface [polypeptide binding]; other site 881621000132 active site 881621000133 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 881621000134 dimer interface [polypeptide binding]; other site 881621000135 active site 881621000136 putrescine carbamoyltransferase; Provisional; Region: PRK02255 881621000137 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 881621000138 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621000139 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 881621000140 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 881621000141 agmatine deiminase; Region: agmatine_aguA; TIGR03380 881621000142 carbamate kinase; Reviewed; Region: PRK12686 881621000143 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 881621000144 putative substrate binding site [chemical binding]; other site 881621000145 nucleotide binding site [chemical binding]; other site 881621000146 nucleotide binding site [chemical binding]; other site 881621000147 homodimer interface [polypeptide binding]; other site 881621000148 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 881621000149 agmatine deiminase; Region: agmatine_aguA; TIGR03380 881621000150 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 881621000151 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 881621000152 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 881621000153 putative active site [active] 881621000154 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 881621000155 Amidinotransferase; Region: Amidinotransf; cl12043 881621000156 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 881621000157 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 881621000158 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 881621000159 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 881621000160 dimer interface [polypeptide binding]; other site 881621000161 ssDNA binding site [nucleotide binding]; other site 881621000162 tetramer (dimer of dimers) interface [polypeptide binding]; other site 881621000163 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 881621000164 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 881621000165 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 881621000166 Accessory gene regulator B; Region: AgrB; cl01873 881621000167 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 881621000168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 881621000169 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 881621000170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 881621000171 active site 881621000172 phosphorylation site [posttranslational modification] 881621000173 intermolecular recognition site; other site 881621000174 dimerization interface [polypeptide binding]; other site 881621000175 LytTr DNA-binding domain; Region: LytTR; cl04498 881621000176 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 881621000177 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 881621000178 DHH family; Region: DHH; pfam01368 881621000179 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 881621000180 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 881621000181 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 881621000182 replicative DNA helicase; Provisional; Region: PRK05748 881621000183 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 881621000184 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 881621000185 Walker A motif; other site 881621000186 ATP binding site [chemical binding]; other site 881621000187 Walker B motif; other site 881621000188 DNA binding loops [nucleotide binding] 881621000189 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 881621000190 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 881621000191 GDP-binding site [chemical binding]; other site 881621000192 ACT binding site; other site 881621000193 IMP binding site; other site 881621000194 Proteins of 100 residues with WXG; Region: WXG100; cl02005 881621000195 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 881621000196 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 881621000197 Predicted membrane protein [Function unknown]; Region: COG1511 881621000198 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 881621000199 Ubiquitin-like proteins; Region: UBQ; cl00155 881621000200 similar to Bacillus subtilis YukA protein possibly involved in protein secretion, N-terminal part 881621000201 similar to Bacillus subtilis YukA protein possibly involved in protein secretion, C-terminal part 881621000202 Proteins of 100 residues with WXG; Region: WXG100; cl02005 881621000203 Uncharacterized conserved protein [Function unknown]; Region: COG5444 881621000204 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 881621000205 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 881621000206 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 881621000207 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 881621000208 tetramer interface [polypeptide binding]; other site 881621000209 active site 881621000210 Mg2+/Mn2+ binding site [ion binding]; other site 881621000211 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 881621000212 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 881621000213 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 881621000214 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 881621000215 DNA binding site [nucleotide binding] 881621000216 active site 881621000217 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 881621000218 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 881621000219 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 881621000220 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621000221 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 881621000222 active site 881621000223 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621000224 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621000225 LRR adjacent; Region: LRR_adjacent; pfam08191 881621000226 SH3-like domain; Region: SH3_8; pfam13457 881621000227 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621000228 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 881621000229 LRR adjacent; Region: LRR_adjacent; pfam08191 881621000230 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 881621000231 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621000232 DNA-binding site [nucleotide binding]; DNA binding site 881621000233 UTRA domain; Region: UTRA; cl01230 881621000234 YdjC-like protein; Region: YdjC; cl01344 881621000235 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 881621000236 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 881621000237 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 881621000238 active site turn [active] 881621000239 phosphorylation site [posttranslational modification] 881621000240 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 881621000241 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621000242 NAD(P) binding site [chemical binding]; other site 881621000243 LDH/MDH dimer interface [polypeptide binding]; other site 881621000244 substrate binding site [chemical binding]; other site 881621000245 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 881621000246 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 881621000247 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 881621000248 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 881621000249 intersubunit interface [polypeptide binding]; other site 881621000250 active site 881621000251 Zn2+ binding site [ion binding]; other site 881621000252 L-rhamnulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 881621000253 N- and C-terminal domain interface [polypeptide binding]; other site 881621000254 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 881621000255 active site 881621000256 catalytic site [active] 881621000257 metal binding site [ion binding]; metal-binding site 881621000258 ATP binding site [chemical binding]; other site 881621000259 carbohydrate binding site [chemical binding]; other site 881621000260 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 881621000261 L-fucose isomerase; Provisional; Region: fucI; PRK10991 881621000262 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 881621000263 hexamer (dimer of trimers) interface [polypeptide binding]; other site 881621000264 trimer interface [polypeptide binding]; other site 881621000265 substrate binding site [chemical binding]; other site 881621000266 Mn binding site [ion binding]; other site 881621000267 Ion channel; Region: Ion_trans_2; cl11596 881621000268 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621000269 non-specific DNA binding site [nucleotide binding]; other site 881621000270 salt bridge; other site 881621000271 sequence-specific DNA binding site [nucleotide binding]; other site 881621000272 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 881621000273 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 881621000274 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 881621000275 active pocket/dimerization site; other site 881621000276 active site 881621000277 phosphorylation site [posttranslational modification] 881621000278 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 881621000279 active site 881621000280 phosphorylation site [posttranslational modification] 881621000281 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 881621000282 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 881621000283 Domain of unknown function (DUF956); Region: DUF956; cl01917 881621000284 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; cl02047 881621000285 Cupin domain; Region: Cupin_2; cl09118 881621000286 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 881621000287 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621000288 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 881621000289 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 881621000290 active site turn [active] 881621000291 phosphorylation site [posttranslational modification] 881621000292 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 881621000293 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 881621000294 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 881621000295 dimerization interface [polypeptide binding]; other site 881621000296 putative DNA binding site [nucleotide binding]; other site 881621000297 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 881621000298 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 881621000299 dimer interface [polypeptide binding]; other site 881621000300 FMN binding site [chemical binding]; other site 881621000301 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 881621000302 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 881621000303 active site 881621000304 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 881621000305 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036 881621000306 chitin/cellulose binding site [chemical binding]; other site 881621000307 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 881621000308 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 881621000309 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 881621000310 Walker A/P-loop; other site 881621000311 ATP binding site [chemical binding]; other site 881621000312 Q-loop/lid; other site 881621000313 ABC transporter signature motif; other site 881621000314 Walker B; other site 881621000315 D-loop; other site 881621000316 H-loop/switch region; other site 881621000317 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 881621000318 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 881621000319 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 881621000320 Walker A/P-loop; other site 881621000321 ATP binding site [chemical binding]; other site 881621000322 Q-loop/lid; other site 881621000323 ABC transporter signature motif; other site 881621000324 Walker B; other site 881621000325 D-loop; other site 881621000326 H-loop/switch region; other site 881621000327 Cupin domain; Region: Cupin_2; cl09118 881621000328 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621000329 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 881621000330 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621000331 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621000332 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 881621000333 substrate binding pocket [chemical binding]; other site 881621000334 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621000335 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 881621000336 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621000337 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 881621000338 ligand binding site [chemical binding]; other site 881621000339 flexible hinge region; other site 881621000340 Helix-turn-helix domains; Region: HTH; cl00088 881621000341 Domain of unknown function (DUF955); Region: DUF955; cl01076 881621000342 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621000343 non-specific DNA binding site [nucleotide binding]; other site 881621000344 salt bridge; other site 881621000345 sequence-specific DNA binding site [nucleotide binding]; other site 881621000346 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 881621000347 Holin family; Region: Phage_holin_4; cl01989 881621000348 Similar to autolysin: N-acetylmuramoyl-L-alanine amidase 881621000349 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 881621000350 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 881621000351 putative active site [active] 881621000352 putative metal binding site [ion binding]; other site 881621000353 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 881621000354 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 881621000355 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 881621000356 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 881621000357 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH_2; cd04602 881621000358 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 881621000359 active site 881621000360 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 881621000361 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621000362 Coenzyme A binding pocket [chemical binding]; other site 881621000363 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 881621000364 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 881621000365 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 881621000366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621000367 dimer interface [polypeptide binding]; other site 881621000368 conserved gate region; other site 881621000369 putative PBP binding loops; other site 881621000370 ABC-ATPase subunit interface; other site 881621000371 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 881621000372 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 881621000373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621000374 dimer interface [polypeptide binding]; other site 881621000375 conserved gate region; other site 881621000376 putative PBP binding loops; other site 881621000377 ABC-ATPase subunit interface; other site 881621000378 similar to unknown protein, partial 881621000379 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 881621000380 peptide binding site [polypeptide binding]; other site 881621000381 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 881621000382 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 881621000383 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 881621000384 metal binding site [ion binding]; metal-binding site 881621000385 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 881621000386 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 881621000387 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 881621000388 ABC-ATPase subunit interface; other site 881621000389 dimer interface [polypeptide binding]; other site 881621000390 putative PBP binding regions; other site 881621000391 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621000392 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 881621000393 ligand binding site [chemical binding]; other site 881621000394 flexible hinge region; other site 881621000395 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 881621000396 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 881621000397 DEAD_2; Region: DEAD_2; pfam06733 881621000398 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621000399 sugar phosphate phosphatase; Provisional; Region: PRK10513 881621000400 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621000401 active site 881621000402 motif I; other site 881621000403 motif II; other site 881621000404 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621000405 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 881621000406 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 881621000407 active site 881621000408 NlpC/P60 family; Region: NLPC_P60; cl11438 881621000409 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 881621000410 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 881621000411 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 881621000412 peptide binding site [polypeptide binding]; other site 881621000413 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 881621000414 SxDxEG motif; other site 881621000415 active site 881621000416 metal binding site [ion binding]; metal-binding site 881621000417 homopentamer interface [polypeptide binding]; other site 881621000418 Helix-turn-helix domains; Region: HTH; cl00088 881621000419 putative transposase OrfB; Reviewed; Region: PHA02517 881621000420 HTH-like domain; Region: HTH_21; pfam13276 881621000421 Integrase core domain; Region: rve; cl01316 881621000422 Integrase core domain; Region: rve_3; cl15866 881621000423 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 881621000424 Collagen binding domain; Region: Collagen_bind; pfam05737 881621000425 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 881621000426 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 881621000427 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 881621000428 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 881621000429 DNA polymerase III subunit delta'; Validated; Region: PRK08058 881621000430 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621000431 PSP1 C-terminal conserved region; Region: PSP1; cl00770 881621000432 TSC-22/dip/bun family; Region: TSC22; cl01853 881621000433 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 881621000434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 881621000435 S-adenosylmethionine binding site [chemical binding]; other site 881621000436 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 881621000437 GIY-YIG motif/motif A; other site 881621000438 putative active site [active] 881621000439 putative metal binding site [ion binding]; other site 881621000440 Predicted methyltransferases [General function prediction only]; Region: COG0313 881621000441 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 881621000442 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 881621000443 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 881621000444 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 881621000445 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 881621000446 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 881621000447 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 881621000448 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 881621000449 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 881621000450 active site 881621000451 HIGH motif; other site 881621000452 KMSKS motif; other site 881621000453 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 881621000454 tRNA binding surface [nucleotide binding]; other site 881621000455 anticodon binding site; other site 881621000456 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 881621000457 dimer interface [polypeptide binding]; other site 881621000458 putative tRNA-binding site [nucleotide binding]; other site 881621000459 Helix-turn-helix domains; Region: HTH; cl00088 881621000460 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 881621000461 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 881621000462 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 881621000463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621000464 dimer interface [polypeptide binding]; other site 881621000465 conserved gate region; other site 881621000466 putative PBP binding loops; other site 881621000467 ABC-ATPase subunit interface; other site 881621000468 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 881621000469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621000470 dimer interface [polypeptide binding]; other site 881621000471 conserved gate region; other site 881621000472 putative PBP binding loops; other site 881621000473 ABC-ATPase subunit interface; other site 881621000474 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 881621000475 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 881621000476 alpha-glucosidase; Provisional; Region: PRK10426 881621000477 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 881621000478 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 881621000479 active site 881621000480 catalytic site [active] 881621000481 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 881621000482 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 881621000483 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 881621000484 trimer interface [polypeptide binding]; other site 881621000485 active site 881621000486 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 881621000487 catalytic site [active] 881621000488 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 881621000489 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 881621000490 Ca binding site [ion binding]; other site 881621000491 active site 881621000492 catalytic site [active] 881621000493 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 881621000494 active site 881621000495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 881621000496 Domain of unknown function (DUF348); Region: DUF348; pfam03990 881621000497 Domain of unknown function (DUF348); Region: DUF348; pfam03990 881621000498 Domain of unknown function (DUF348); Region: DUF348; pfam03990 881621000499 G5 domain; Region: G5; pfam07501 881621000500 3D domain; Region: 3D; cl01439 881621000501 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 881621000502 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 881621000503 putative active site [active] 881621000504 putative metal binding site [ion binding]; other site 881621000505 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 881621000506 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621000507 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 881621000508 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 881621000509 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 881621000510 YdjC-like protein; Region: YdjC; cl01344 881621000511 pur operon repressor; Provisional; Region: PRK09213 881621000512 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 881621000513 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 881621000514 active site 881621000515 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 881621000516 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 881621000517 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621000518 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 881621000519 Walker A/P-loop; other site 881621000520 ATP binding site [chemical binding]; other site 881621000521 Q-loop/lid; other site 881621000522 ABC transporter signature motif; other site 881621000523 Walker B; other site 881621000524 D-loop; other site 881621000525 H-loop/switch region; other site 881621000526 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 881621000527 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 881621000528 FtsX-like permease family; Region: FtsX; cl15850 881621000529 SpoVG; Region: SpoVG; cl00915 881621000530 SpoVG; Region: SpoVG; cl00915 881621000531 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 881621000532 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 881621000533 Substrate binding site; other site 881621000534 Mg++ binding site; other site 881621000535 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 881621000536 active site 881621000537 substrate binding site [chemical binding]; other site 881621000538 CoA binding site [chemical binding]; other site 881621000539 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 881621000540 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 881621000541 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 881621000542 active site 881621000543 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621000544 Helix-turn-helix domains; Region: HTH; cl00088 881621000545 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 881621000546 ActA Protein; Region: ActA; pfam05058 881621000547 ActA Protein; Region: ActA; pfam05058 881621000548 ActA Protein; Region: ActA; pfam05058 881621000549 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 881621000550 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 881621000551 active site 881621000552 metal binding site [ion binding]; metal-binding site 881621000553 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 881621000554 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 881621000555 A new structural DNA glycosylase; Region: AlkD_like; cl11434 881621000556 active site 881621000557 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 881621000558 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 881621000559 tetramer (dimer of dimers) interface [polypeptide binding]; other site 881621000560 NAD binding site [chemical binding]; other site 881621000561 dimer interface [polypeptide binding]; other site 881621000562 substrate binding site [chemical binding]; other site 881621000563 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 881621000564 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 881621000565 5S rRNA interface [nucleotide binding]; other site 881621000566 CTC domain interface [polypeptide binding]; other site 881621000567 L16 interface [polypeptide binding]; other site 881621000568 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 881621000569 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621000570 Coenzyme A binding pocket [chemical binding]; other site 881621000571 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 881621000572 putative active site [active] 881621000573 catalytic residue [active] 881621000574 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 881621000575 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 881621000576 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 881621000577 ATP binding site [chemical binding]; other site 881621000578 putative Mg++ binding site [ion binding]; other site 881621000579 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621000580 nucleotide binding region [chemical binding]; other site 881621000581 ATP-binding site [chemical binding]; other site 881621000582 TRCF domain; Region: TRCF; cl04088 881621000583 stage V sporulation protein B; Region: spore_V_B; TIGR02900 881621000584 MatE; Region: MatE; cl10513 881621000585 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 881621000586 RNA binding surface [nucleotide binding]; other site 881621000587 Septum formation initiator; Region: DivIC; cl11433 881621000588 hypothetical protein; Provisional; Region: PRK08582 881621000589 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 881621000590 RNA binding site [nucleotide binding]; other site 881621000591 FtsH Extracellular; Region: FtsH_ext; pfam06480 881621000592 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 881621000593 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621000594 Walker A motif; other site 881621000595 ATP binding site [chemical binding]; other site 881621000596 Walker B motif; other site 881621000597 arginine finger; other site 881621000598 Peptidase family M41; Region: Peptidase_M41; pfam01434 881621000599 Type III pantothenate kinase; Region: Pan_kinase; cl09130 881621000600 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 881621000601 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 881621000602 dimerization interface [polypeptide binding]; other site 881621000603 domain crossover interface; other site 881621000604 redox-dependent activation switch; other site 881621000605 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 881621000606 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 881621000607 dimer interface [polypeptide binding]; other site 881621000608 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621000609 catalytic residue [active] 881621000610 dihydropteroate synthase; Region: DHPS; TIGR01496 881621000611 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 881621000612 substrate binding pocket [chemical binding]; other site 881621000613 dimer interface [polypeptide binding]; other site 881621000614 inhibitor binding site; inhibition site 881621000615 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 881621000616 homooctamer interface [polypeptide binding]; other site 881621000617 active site 881621000618 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 881621000619 catalytic center binding site [active] 881621000620 ATP binding site [chemical binding]; other site 881621000621 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 881621000622 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 881621000623 FMN binding site [chemical binding]; other site 881621000624 active site 881621000625 catalytic residues [active] 881621000626 substrate binding site [chemical binding]; other site 881621000627 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 881621000628 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 881621000629 dimer interface [polypeptide binding]; other site 881621000630 putative anticodon binding site; other site 881621000631 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 881621000632 motif 1; other site 881621000633 active site 881621000634 motif 2; other site 881621000635 motif 3; other site 881621000636 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 881621000637 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 881621000638 UvrB/uvrC motif; Region: UVR; pfam02151 881621000639 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 881621000640 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 881621000641 ADP binding site [chemical binding]; other site 881621000642 phosphagen binding site; other site 881621000643 substrate specificity loop; other site 881621000644 Clp protease ATP binding subunit; Region: clpC; CHL00095 881621000645 Clp amino terminal domain; Region: Clp_N; pfam02861 881621000646 Clp amino terminal domain; Region: Clp_N; pfam02861 881621000647 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621000648 Walker A motif; other site 881621000649 ATP binding site [chemical binding]; other site 881621000650 Walker B motif; other site 881621000651 arginine finger; other site 881621000652 UvrB/uvrC motif; Region: UVR; pfam02151 881621000653 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621000654 Walker A motif; other site 881621000655 ATP binding site [chemical binding]; other site 881621000656 Walker B motif; other site 881621000657 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 881621000658 DNA repair protein RadA; Provisional; Region: PRK11823 881621000659 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 881621000660 Walker A motif/ATP binding site; other site 881621000661 ATP binding site [chemical binding]; other site 881621000662 Walker B motif; other site 881621000663 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 881621000664 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 881621000665 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 881621000666 putative active site [active] 881621000667 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 881621000668 substrate binding site; other site 881621000669 dimer interface; other site 881621000670 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 881621000671 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 881621000672 HIGH motif; other site 881621000673 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 881621000674 active site 881621000675 KMSKS motif; other site 881621000676 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 881621000677 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 881621000678 putative DNA binding site [nucleotide binding]; other site 881621000679 putative Zn2+ binding site [ion binding]; other site 881621000680 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 881621000681 similar to pyruvate-formate lyase activating enzyme, partial 881621000682 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 881621000683 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 881621000684 putative active site cavity [active] 881621000685 similar to putative pyruvate formate-lyase 2,N-terminal part 881621000686 similar to putative pyruvate formate-lyase 2,C-terminal part 881621000687 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 881621000688 active site 881621000689 phosphorylation site [posttranslational modification] 881621000690 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 881621000691 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 881621000692 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 881621000693 active pocket/dimerization site; other site 881621000694 active site 881621000695 phosphorylation site [posttranslational modification] 881621000696 serine O-acetyltransferase; Region: cysE; TIGR01172 881621000697 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 881621000698 trimer interface [polypeptide binding]; other site 881621000699 active site 881621000700 substrate binding site [chemical binding]; other site 881621000701 CoA binding site [chemical binding]; other site 881621000702 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 881621000703 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 881621000704 active site 881621000705 HIGH motif; other site 881621000706 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 881621000707 KMSKS motif; other site 881621000708 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 881621000709 tRNA binding surface [nucleotide binding]; other site 881621000710 anticodon binding site; other site 881621000711 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 881621000712 active site 881621000713 metal binding site [ion binding]; metal-binding site 881621000714 dimerization interface [polypeptide binding]; other site 881621000715 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 881621000716 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 881621000717 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 881621000718 YacP-like NYN domain; Region: NYN_YacP; cl01491 881621000719 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 881621000720 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 881621000721 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 881621000722 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 881621000723 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 881621000724 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 881621000725 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 881621000726 putative homodimer interface [polypeptide binding]; other site 881621000727 KOW motif; Region: KOW; cl00354 881621000728 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 881621000729 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 881621000730 23S rRNA interface [nucleotide binding]; other site 881621000731 L7/L12 interface [polypeptide binding]; other site 881621000732 putative thiostrepton binding site; other site 881621000733 L25 interface [polypeptide binding]; other site 881621000734 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 881621000735 mRNA/rRNA interface [nucleotide binding]; other site 881621000736 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 881621000737 23S rRNA interface [nucleotide binding]; other site 881621000738 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 881621000739 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 881621000740 core dimer interface [polypeptide binding]; other site 881621000741 peripheral dimer interface [polypeptide binding]; other site 881621000742 L10 interface [polypeptide binding]; other site 881621000743 L11 interface [polypeptide binding]; other site 881621000744 putative EF-Tu interaction site [polypeptide binding]; other site 881621000745 putative EF-G interaction site [polypeptide binding]; other site 881621000746 Methyltransferase domain; Region: Methyltransf_31; pfam13847 881621000747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 881621000748 S-adenosylmethionine binding site [chemical binding]; other site 881621000749 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 881621000750 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621000751 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621000752 DNA binding site [nucleotide binding] 881621000753 domain linker motif; other site 881621000754 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 881621000755 putative dimerization interface [polypeptide binding]; other site 881621000756 putative ligand binding site [chemical binding]; other site 881621000757 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 881621000758 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 881621000759 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 881621000760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621000761 dimer interface [polypeptide binding]; other site 881621000762 conserved gate region; other site 881621000763 putative PBP binding loops; other site 881621000764 ABC-ATPase subunit interface; other site 881621000765 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 881621000766 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621000767 dimer interface [polypeptide binding]; other site 881621000768 conserved gate region; other site 881621000769 putative PBP binding loops; other site 881621000770 ABC-ATPase subunit interface; other site 881621000771 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 881621000772 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 881621000773 Ca binding site [ion binding]; other site 881621000774 active site 881621000775 catalytic site [active] 881621000776 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 881621000777 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 881621000778 active site 881621000779 homodimer interface [polypeptide binding]; other site 881621000780 catalytic site [active] 881621000781 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 881621000782 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 881621000783 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 881621000784 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 881621000785 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 881621000786 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 881621000787 RPB10 interaction site [polypeptide binding]; other site 881621000788 RPB1 interaction site [polypeptide binding]; other site 881621000789 RPB11 interaction site [polypeptide binding]; other site 881621000790 RPB3 interaction site [polypeptide binding]; other site 881621000791 RPB12 interaction site [polypeptide binding]; other site 881621000792 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 881621000793 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 881621000794 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 881621000795 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 881621000796 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 881621000797 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 881621000798 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 881621000799 G-loop; other site 881621000800 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 881621000801 DNA binding site [nucleotide binding] 881621000802 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 881621000803 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 881621000804 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621000805 active site 881621000806 motif I; other site 881621000807 motif II; other site 881621000808 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 881621000809 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 881621000810 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 881621000811 metal binding site [ion binding]; metal-binding site 881621000812 dimer interface [polypeptide binding]; other site 881621000813 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 881621000814 Helix-turn-helix domains; Region: HTH; cl00088 881621000815 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 881621000816 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 881621000817 Zn binding site [ion binding]; other site 881621000818 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 881621000819 Zn binding site [ion binding]; other site 881621000820 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621000821 catalytic core [active] 881621000822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 881621000823 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 881621000824 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 881621000825 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 881621000826 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621000827 Coenzyme A binding pocket [chemical binding]; other site 881621000828 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 881621000829 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621000830 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 881621000831 similar to unknown protein, C-terminal part 881621000832 similar to unknown protein, N-terminal part, start codon is missing 881621000833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621000834 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 881621000835 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 881621000836 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 881621000837 Walker A/P-loop; other site 881621000838 ATP binding site [chemical binding]; other site 881621000839 Q-loop/lid; other site 881621000840 ABC transporter signature motif; other site 881621000841 Walker B; other site 881621000842 D-loop; other site 881621000843 H-loop/switch region; other site 881621000844 TOBE domain; Region: TOBE_2; cl01440 881621000845 ATP cone domain; Region: ATP-cone; pfam03477 881621000846 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 881621000847 Class III ribonucleotide reductase; Region: RNR_III; cd01675 881621000848 effector binding site; other site 881621000849 active site 881621000850 Zn binding site [ion binding]; other site 881621000851 glycine loop; other site 881621000852 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 881621000853 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 881621000854 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621000855 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 881621000856 Predicted amidohydrolase [General function prediction only]; Region: COG0388 881621000857 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 881621000858 putative active site [active] 881621000859 catalytic triad [active] 881621000860 putative dimer interface [polypeptide binding]; other site 881621000861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621000862 dimer interface [polypeptide binding]; other site 881621000863 conserved gate region; other site 881621000864 ABC-ATPase subunit interface; other site 881621000865 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 881621000866 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 881621000867 Walker A/P-loop; other site 881621000868 ATP binding site [chemical binding]; other site 881621000869 Q-loop/lid; other site 881621000870 ABC transporter signature motif; other site 881621000871 Walker B; other site 881621000872 D-loop; other site 881621000873 H-loop/switch region; other site 881621000874 NIL domain; Region: NIL; cl09633 881621000875 NMT1-like family; Region: NMT1_2; cl15260 881621000876 transaminase; Reviewed; Region: PRK08068 881621000877 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 881621000878 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621000879 homodimer interface [polypeptide binding]; other site 881621000880 catalytic residue [active] 881621000881 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 881621000882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 881621000883 active site 881621000884 phosphorylation site [posttranslational modification] 881621000885 intermolecular recognition site; other site 881621000886 dimerization interface [polypeptide binding]; other site 881621000887 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 881621000888 DNA binding site [nucleotide binding] 881621000889 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 881621000890 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 881621000891 dimerization interface [polypeptide binding]; other site 881621000892 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 881621000893 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 881621000894 dimer interface [polypeptide binding]; other site 881621000895 phosphorylation site [posttranslational modification] 881621000896 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621000897 ATP binding site [chemical binding]; other site 881621000898 Mg2+ binding site [ion binding]; other site 881621000899 G-X-G motif; other site 881621000900 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 881621000901 YycH protein; Region: YycH; pfam07435 881621000902 YycH protein; Region: YycI; cl02015 881621000903 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 881621000904 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 881621000905 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 881621000906 protein binding site [polypeptide binding]; other site 881621000907 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 881621000908 transcriptional antiterminator BglG; Provisional; Region: PRK09772 881621000909 CAT RNA binding domain; Region: CAT_RBD; cl03904 881621000910 PRD domain; Region: PRD; cl15445 881621000911 PRD domain; Region: PRD; cl15445 881621000912 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 881621000913 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 881621000914 active site turn [active] 881621000915 phosphorylation site [posttranslational modification] 881621000916 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 881621000917 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 881621000918 HPr interaction site; other site 881621000919 glycerol kinase (GK) interaction site [polypeptide binding]; other site 881621000920 active site 881621000921 phosphorylation site [posttranslational modification] 881621000922 Protein of unknown function (DUF998); Region: DUF998; pfam06197 881621000923 similar to transcriptional antiterminator (BglG family), C-terminal part 881621000924 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621000925 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 881621000926 Walker A/P-loop; other site 881621000927 ATP binding site [chemical binding]; other site 881621000928 Q-loop/lid; other site 881621000929 ABC transporter signature motif; other site 881621000930 Walker B; other site 881621000931 D-loop; other site 881621000932 H-loop/switch region; other site 881621000933 similar to unknown proteins, C-terminal part 881621000934 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 881621000935 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 881621000936 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 881621000937 AMP-binding enzyme; Region: AMP-binding; cl15778 881621000938 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 881621000939 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621000940 putative oxidoreductase; Provisional; Region: PRK10206 881621000941 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621000942 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 881621000943 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621000944 active site 881621000945 phosphorylation site [posttranslational modification] 881621000946 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 881621000947 P-loop; other site 881621000948 active site 881621000949 phosphorylation site [posttranslational modification] 881621000950 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 881621000951 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 881621000952 hypothetical protein; Provisional; Region: PRK08185 881621000953 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 881621000954 intersubunit interface [polypeptide binding]; other site 881621000955 active site 881621000956 zinc binding site [ion binding]; other site 881621000957 Na+ binding site [ion binding]; other site 881621000958 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 881621000959 Helix-turn-helix domains; Region: HTH; cl00088 881621000960 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 881621000961 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 881621000962 conserved cys residue [active] 881621000963 Predicted transcriptional regulator [Transcription]; Region: COG2378 881621000964 Helix-turn-helix domains; Region: HTH; cl00088 881621000965 WYL domain; Region: WYL; cl14852 881621000966 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 881621000967 nudix motif; other site 881621000968 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 881621000969 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 881621000970 PhnA protein; Region: PhnA; pfam03831 881621000971 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 881621000972 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621000973 DNA-binding site [nucleotide binding]; DNA binding site 881621000974 UTRA domain; Region: UTRA; cl01230 881621000975 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 881621000976 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 881621000977 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 881621000978 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 881621000979 active site 881621000980 P-loop; other site 881621000981 phosphorylation site [posttranslational modification] 881621000982 Predicted transcriptional regulator [Transcription]; Region: COG2378 881621000983 Helix-turn-helix domains; Region: HTH; cl00088 881621000984 WYL domain; Region: WYL; cl14852 881621000985 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 881621000986 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621000987 non-specific DNA binding site [nucleotide binding]; other site 881621000988 salt bridge; other site 881621000989 sequence-specific DNA binding site [nucleotide binding]; other site 881621000990 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 881621000991 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 881621000992 tetrameric interface [polypeptide binding]; other site 881621000993 NAD binding site [chemical binding]; other site 881621000994 catalytic residues [active] 881621000995 KduI/IolB family; Region: KduI; cl01508 881621000996 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 881621000997 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 881621000998 substrate binding site [chemical binding]; other site 881621000999 ATP binding site [chemical binding]; other site 881621001000 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 881621001001 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 881621001002 PYR/PP interface [polypeptide binding]; other site 881621001003 dimer interface [polypeptide binding]; other site 881621001004 TPP binding site [chemical binding]; other site 881621001005 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 881621001006 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 881621001007 TPP-binding site; other site 881621001008 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 881621001009 Protein of unknown function (DUF419); Region: DUF419; cl15265 881621001010 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 881621001011 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 881621001012 ligand binding site [chemical binding]; other site 881621001013 active site 881621001014 UGI interface [polypeptide binding]; other site 881621001015 catalytic site [active] 881621001016 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 881621001017 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 881621001018 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 881621001019 NodB motif; other site 881621001020 active site 881621001021 catalytic site [active] 881621001022 Zn binding site [ion binding]; other site 881621001023 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 881621001024 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 881621001025 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 881621001026 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 881621001027 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 881621001028 DNA binding residues [nucleotide binding] 881621001029 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621001030 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 881621001031 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 881621001032 DXD motif; other site 881621001033 similar to unknown protein, C-terminal part 881621001034 similar to unknown protein, N-terminal part 881621001035 Bacterial SH3 domain; Region: SH3_3; cl02551 881621001036 NlpC/P60 family; Region: NLPC_P60; cl11438 881621001037 possibly truncated gene (N-terminal part) 881621001038 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 881621001039 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621001040 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621001041 Gram positive anchor; Region: Gram_pos_anchor; cl15427 881621001042 Transcriptional regulators [Transcription]; Region: GntR; COG1802 881621001043 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621001044 DNA-binding site [nucleotide binding]; DNA binding site 881621001045 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 881621001046 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621001047 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 881621001048 Walker A/P-loop; other site 881621001049 ATP binding site [chemical binding]; other site 881621001050 Q-loop/lid; other site 881621001051 ABC transporter signature motif; other site 881621001052 Walker B; other site 881621001053 D-loop; other site 881621001054 H-loop/switch region; other site 881621001055 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 881621001056 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 881621001057 FtsX-like permease family; Region: FtsX; cl15850 881621001058 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 881621001059 putative hydrophobic ligand binding site [chemical binding]; other site 881621001060 Phosphate transporter family; Region: PHO4; cl00396 881621001061 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 881621001062 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 881621001063 putative metal binding site [ion binding]; other site 881621001064 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 881621001065 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 881621001066 trimer interface [polypeptide binding]; other site 881621001067 phosphoenolpyruvate synthase; Validated; Region: PRK06241 881621001068 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 881621001069 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 881621001070 similar to unknown protein, C-terminal part 881621001071 similar to unknown protein, N-terminal part 881621001072 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 881621001073 ZIP Zinc transporter; Region: Zip; pfam02535 881621001074 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 881621001075 NodB motif; other site 881621001076 active site 881621001077 catalytic site [active] 881621001078 amidase; Provisional; Region: PRK06707 881621001079 Amidase; Region: Amidase; cl11426 881621001080 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 881621001081 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 881621001082 classical (c) SDRs; Region: SDR_c; cd05233 881621001083 NAD(P) binding site [chemical binding]; other site 881621001084 active site 881621001085 QueT transporter; Region: QueT; cl01932 881621001086 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621001087 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 881621001088 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001089 Leucine rich repeat; Region: LRR_8; pfam13855 881621001090 LRR adjacent; Region: LRR_adjacent; pfam08191 881621001091 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621001092 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 881621001093 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 881621001094 LRR adjacent; Region: LRR_adjacent; pfam08191 881621001095 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 881621001096 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 881621001097 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 881621001098 Gram positive anchor; Region: Gram_pos_anchor; cl15427 881621001099 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621001100 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 881621001101 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001102 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001103 LRR adjacent; Region: LRR_adjacent; pfam08191 881621001104 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 881621001105 SH3-like domain; Region: SH3_8; pfam13457 881621001106 SH3-like domain; Region: SH3_8; pfam13457 881621001107 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621001108 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 881621001109 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001110 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001111 Leucine rich repeat; Region: LRR_8; pfam13855 881621001112 LRR adjacent; Region: LRR_adjacent; pfam08191 881621001113 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 881621001114 SH3-like domain; Region: SH3_8; pfam13457 881621001115 SH3-like domain; Region: SH3_8; pfam13457 881621001116 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 881621001117 Protein of unknown function (DUF2004); Region: DUF2004; pfam09406 881621001118 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 881621001119 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 881621001120 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 881621001121 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 881621001122 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 881621001123 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 881621001124 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 881621001125 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 881621001126 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 881621001127 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 881621001128 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 881621001129 Helix-turn-helix domains; Region: HTH; cl00088 881621001130 Sodium:solute symporter family; Region: SSF; cl00456 881621001131 Uncharacterized conserved protein [Function unknown]; Region: COG3535 881621001132 Protein of unknown function (DUF917); Region: DUF917; pfam06032 881621001133 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 881621001134 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 881621001135 Protein of unknown function (DUF3130; Region: DUF3130; pfam11328 881621001136 similar to unknown protein, N-terminal part 881621001137 similar to unknown protein, central part 881621001138 similar to unknown protein, partial 881621001139 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 881621001140 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 881621001141 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 881621001142 Helix-turn-helix domains; Region: HTH; cl00088 881621001143 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621001144 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 881621001145 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 881621001146 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 881621001147 FeS/SAM binding site; other site 881621001148 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 881621001149 similar to unknown protein, C-terminal part 881621001150 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 881621001151 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 881621001152 putative active site [active] 881621001153 putative nucleic acid binding site [nucleotide binding]; other site 881621001154 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621001155 non-specific DNA binding site [nucleotide binding]; other site 881621001156 salt bridge; other site 881621001157 sequence-specific DNA binding site [nucleotide binding]; other site 881621001158 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 881621001159 putative FMN binding site [chemical binding]; other site 881621001160 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 881621001161 oxidoreductase; Provisional; Region: PRK07985 881621001162 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621001163 NAD(P) binding site [chemical binding]; other site 881621001164 active site 881621001165 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 881621001166 similar to unknown protein, partial 881621001167 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 881621001168 nudix motif; other site 881621001169 Transcriptional regulator [Transcription]; Region: LysR; COG0583 881621001170 Helix-turn-helix domains; Region: HTH; cl00088 881621001171 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 881621001172 putative dimerization interface [polypeptide binding]; other site 881621001173 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 881621001174 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 881621001175 active site 881621001176 FMN binding site [chemical binding]; other site 881621001177 substrate binding site [chemical binding]; other site 881621001178 putative catalytic residue [active] 881621001179 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 881621001180 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 881621001181 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 881621001182 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 881621001183 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 881621001184 shikimate binding site; other site 881621001185 NAD(P) binding site [chemical binding]; other site 881621001186 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 881621001187 3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093 881621001188 active site 881621001189 catalytic residue [active] 881621001190 dimer interface [polypeptide binding]; other site 881621001191 Transcriptional regulator [Transcription]; Region: LysR; COG0583 881621001192 Helix-turn-helix domains; Region: HTH; cl00088 881621001193 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 881621001194 dimerization interface [polypeptide binding]; other site 881621001195 Predicted acyl esterases [General function prediction only]; Region: COG2936 881621001196 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 881621001197 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 881621001198 active site 881621001199 catalytic triad [active] 881621001200 oxyanion hole [active] 881621001201 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 881621001202 similar to sugar transferase, fragment 881621001203 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 881621001204 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 881621001205 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 881621001206 substrate binding site [chemical binding]; other site 881621001207 hexamer interface [polypeptide binding]; other site 881621001208 metal binding site [ion binding]; metal-binding site 881621001209 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 881621001210 catalytic residue [active] 881621001211 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 881621001212 PRD domain; Region: PRD; cl15445 881621001213 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 881621001214 P-loop; other site 881621001215 active site 881621001216 phosphorylation site [posttranslational modification] 881621001217 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621001218 active site 881621001219 phosphorylation site [posttranslational modification] 881621001220 Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane]; Region: GutQ; COG0794 881621001221 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 881621001222 putative active site [active] 881621001223 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621001224 active site 881621001225 phosphorylation site [posttranslational modification] 881621001226 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 881621001227 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 881621001228 substrate binding site [chemical binding]; other site 881621001229 hexamer interface [polypeptide binding]; other site 881621001230 metal binding site [ion binding]; metal-binding site 881621001231 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 881621001232 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 881621001233 putative NAD(P) binding site [chemical binding]; other site 881621001234 catalytic Zn binding site [ion binding]; other site 881621001235 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 881621001236 P-loop; other site 881621001237 active site 881621001238 phosphorylation site [posttranslational modification] 881621001239 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 881621001240 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 881621001241 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 881621001242 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 881621001243 active site 881621001244 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 881621001245 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 881621001246 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 881621001247 catalytic triad [active] 881621001248 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807 881621001249 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 881621001250 Helix-turn-helix domains; Region: HTH; cl00088 881621001251 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001252 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 881621001253 Ligand Binding Site [chemical binding]; other site 881621001254 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621001255 catalytic core [active] 881621001256 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621001257 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 881621001258 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 881621001259 Walker A/P-loop; other site 881621001260 ATP binding site [chemical binding]; other site 881621001261 Q-loop/lid; other site 881621001262 ABC transporter signature motif; other site 881621001263 Walker B; other site 881621001264 D-loop; other site 881621001265 H-loop/switch region; other site 881621001266 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 881621001267 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09754 881621001268 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 881621001269 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 881621001270 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 881621001271 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 881621001272 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621001273 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 881621001274 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 881621001275 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 881621001276 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 881621001277 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 881621001278 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 881621001279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 881621001280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621001281 dimer interface [polypeptide binding]; other site 881621001282 conserved gate region; other site 881621001283 putative PBP binding loops; other site 881621001284 ABC-ATPase subunit interface; other site 881621001285 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 881621001286 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 881621001287 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 881621001288 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 881621001289 Protein of unknown function (DUF1237); Region: DUF1237; cl15402 881621001290 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 881621001291 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 881621001292 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 881621001293 putative active site [active] 881621001294 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 881621001295 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 881621001296 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 881621001297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621001298 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621001299 putative substrate translocation pore; other site 881621001300 Helix-turn-helix domains; Region: HTH; cl00088 881621001301 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 881621001302 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 881621001303 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 881621001304 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 881621001305 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 881621001306 NAD binding site [chemical binding]; other site 881621001307 sugar binding site [chemical binding]; other site 881621001308 divalent metal binding site [ion binding]; other site 881621001309 tetramer (dimer of dimers) interface [polypeptide binding]; other site 881621001310 dimer interface [polypeptide binding]; other site 881621001311 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 881621001312 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 881621001313 putative active site [active] 881621001314 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 881621001315 Sulfate transporter family; Region: Sulfate_transp; cl15842 881621001316 Sulfate transporter family; Region: Sulfate_transp; cl15842 881621001317 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 881621001318 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 881621001319 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 881621001320 DNA binding residues [nucleotide binding] 881621001321 dimer interface [polypeptide binding]; other site 881621001322 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 881621001323 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 881621001324 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 881621001325 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 881621001326 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 881621001327 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 881621001328 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621001329 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 881621001330 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 881621001331 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621001332 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621001333 DNA binding site [nucleotide binding] 881621001334 domain linker motif; other site 881621001335 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 881621001336 putative dimerization interface [polypeptide binding]; other site 881621001337 putative ligand binding site [chemical binding]; other site 881621001338 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 881621001339 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 881621001340 NAD binding site [chemical binding]; other site 881621001341 sugar binding site [chemical binding]; other site 881621001342 divalent metal binding site [ion binding]; other site 881621001343 tetramer (dimer of dimers) interface [polypeptide binding]; other site 881621001344 dimer interface [polypeptide binding]; other site 881621001345 allantoate amidohydrolase; Reviewed; Region: PRK09290 881621001346 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 881621001347 active site 881621001348 metal binding site [ion binding]; metal-binding site 881621001349 dimer interface [polypeptide binding]; other site 881621001350 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 881621001351 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 881621001352 metal binding site [ion binding]; metal-binding site 881621001353 putative dimer interface [polypeptide binding]; other site 881621001354 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 881621001355 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 881621001356 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 881621001357 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 881621001358 intersubunit interface [polypeptide binding]; other site 881621001359 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 881621001360 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 881621001361 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 881621001362 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 881621001363 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 881621001364 Glucitol operon activator protein (GutM); Region: GutM; cl01890 881621001365 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 881621001366 SAF domain; Region: SAF; cl00555 881621001367 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 881621001368 Helix-turn-helix domains; Region: HTH; cl00088 881621001369 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 881621001370 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 881621001371 Leucine-rich repeats; other site 881621001372 Substrate binding site [chemical binding]; other site 881621001373 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001374 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001375 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001376 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001377 WxL domain surface cell wall-binding; Region: WxL; pfam13731 881621001378 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621001379 WxL domain surface cell wall-binding; Region: WxL; pfam13731 881621001380 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 881621001381 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 881621001382 FOG: CBS domain [General function prediction only]; Region: COG0517 881621001383 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 881621001384 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 881621001385 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 881621001386 dimer interface [polypeptide binding]; other site 881621001387 active site 881621001388 metal binding site [ion binding]; metal-binding site 881621001389 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 881621001390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621001391 putative substrate translocation pore; other site 881621001392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 881621001393 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621001394 catalytic core [active] 881621001395 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621001396 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621001397 catalytic core [active] 881621001398 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621001399 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 881621001400 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 881621001401 glutamate dehydrogenase; Provisional; Region: PRK09414 881621001402 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 881621001403 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 881621001404 NAD(P) binding site [chemical binding]; other site 881621001405 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 881621001406 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 881621001407 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 881621001408 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 881621001409 substrate binding site [chemical binding]; other site 881621001410 glutamase interaction surface [polypeptide binding]; other site 881621001411 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 881621001412 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 881621001413 catalytic residues [active] 881621001414 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 881621001415 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 881621001416 putative active site [active] 881621001417 oxyanion strand; other site 881621001418 catalytic triad [active] 881621001419 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 881621001420 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 881621001421 4-fold oligomerization interface [polypeptide binding]; other site 881621001422 putative active site pocket [active] 881621001423 metal binding residues [ion binding]; metal-binding site 881621001424 3-fold/trimer interface [polypeptide binding]; other site 881621001425 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 881621001426 histidinol dehydrogenase; Region: hisD; TIGR00069 881621001427 NAD binding site [chemical binding]; other site 881621001428 dimerization interface [polypeptide binding]; other site 881621001429 product binding site; other site 881621001430 substrate binding site [chemical binding]; other site 881621001431 zinc binding site [ion binding]; other site 881621001432 catalytic residues [active] 881621001433 ATP phosphoribosyltransferase; Region: HisG; cl15266 881621001434 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 881621001435 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 881621001436 dimer interface [polypeptide binding]; other site 881621001437 motif 1; other site 881621001438 active site 881621001439 motif 2; other site 881621001440 histidinol-phosphatase; Reviewed; Region: PRK08123 881621001441 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 881621001442 DNA binding site [nucleotide binding] 881621001443 active site 881621001444 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 881621001445 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 881621001446 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 881621001447 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 881621001448 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621001449 DNA-binding site [nucleotide binding]; DNA binding site 881621001450 UTRA domain; Region: UTRA; cl01230 881621001451 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 881621001452 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 881621001453 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 881621001454 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 881621001455 N- and C-terminal domain interface [polypeptide binding]; other site 881621001456 D-xylulose kinase; Region: XylB; TIGR01312 881621001457 active site 881621001458 catalytic site [active] 881621001459 metal binding site [ion binding]; metal-binding site 881621001460 xylulose binding site [chemical binding]; other site 881621001461 putative ATP binding site [chemical binding]; other site 881621001462 homodimer interface [polypeptide binding]; other site 881621001463 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 881621001464 Uncharacterized conserved protein [Function unknown]; Region: COG2966 881621001465 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 881621001466 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; cl01839 881621001467 Predicted esterase [General function prediction only]; Region: COG0400 881621001468 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621001469 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 881621001470 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 881621001471 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 881621001472 putative peptidoglycan binding site; other site 881621001473 Bacterial SH3 domain; Region: SH3_3; cl02551 881621001474 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 881621001475 putative peptidoglycan binding site; other site 881621001476 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 881621001477 putative peptidoglycan binding site; other site 881621001478 NlpC/P60 family; Region: NLPC_P60; cl11438 881621001479 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 881621001480 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621001481 ATP binding site [chemical binding]; other site 881621001482 putative Mg++ binding site [ion binding]; other site 881621001483 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 881621001484 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621001485 nucleotide binding region [chemical binding]; other site 881621001486 ATP-binding site [chemical binding]; other site 881621001487 Domain of unknown function DUF20; Region: UPF0118; pfam01594 881621001488 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 881621001489 WxL domain surface cell wall-binding; Region: WxL; pfam13731 881621001490 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 881621001491 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 881621001492 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 881621001493 DNA photolyase; Region: DNA_photolyase; pfam00875 881621001494 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 881621001495 Predicted membrane protein (DUF2177); Region: DUF2177; cl02014 881621001496 DAK2 domain; Region: Dak2; cl03685 881621001497 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 881621001498 Phospholipid methyltransferase; Region: PEMT; cl00763 881621001499 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 881621001500 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 881621001501 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621001502 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 881621001503 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 881621001504 homodimer interface [polypeptide binding]; other site 881621001505 substrate-cofactor binding pocket; other site 881621001506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621001507 catalytic residue [active] 881621001508 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 881621001509 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 881621001510 ligand binding site [chemical binding]; other site 881621001511 flexible hinge region; other site 881621001512 Helix-turn-helix domains; Region: HTH; cl00088 881621001513 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 881621001514 Helix-turn-helix domains; Region: HTH; cl00088 881621001515 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 881621001516 Uncharacterized conserved protein [Function unknown]; Region: COG3595 881621001517 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 881621001518 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 881621001519 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 881621001520 weakly similar to transcription regulator,C-terminal part 881621001521 Tic20-like protein; Region: Tic20; pfam09685 881621001522 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 881621001523 MatE; Region: MatE; cl10513 881621001524 MatE; Region: MatE; cl10513 881621001525 Helix-turn-helix domains; Region: HTH; cl00088 881621001526 transcriptional regulator Hpr; Provisional; Region: PRK13777 881621001527 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 881621001528 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 881621001529 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621001530 Walker A/P-loop; other site 881621001531 ATP binding site [chemical binding]; other site 881621001532 Q-loop/lid; other site 881621001533 ABC transporter signature motif; other site 881621001534 Walker B; other site 881621001535 D-loop; other site 881621001536 H-loop/switch region; other site 881621001537 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 881621001538 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 881621001539 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 881621001540 Walker A/P-loop; other site 881621001541 ATP binding site [chemical binding]; other site 881621001542 Q-loop/lid; other site 881621001543 ABC transporter signature motif; other site 881621001544 Walker B; other site 881621001545 D-loop; other site 881621001546 H-loop/switch region; other site 881621001547 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 881621001548 active site residue [active] 881621001549 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001550 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001551 Gram positive anchor; Region: Gram_pos_anchor; cl15427 881621001552 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 881621001553 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 881621001554 Helix-turn-helix domains; Region: HTH; cl00088 881621001555 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 881621001556 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 881621001557 putative NAD(P) binding site [chemical binding]; other site 881621001558 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 881621001559 similar to glycerophosphodiester phosphodiesterase,partial 881621001560 Catalytic domain of Protein Kinases; Region: PKc; cd00180 881621001561 active site 881621001562 ATP binding site [chemical binding]; other site 881621001563 substrate binding site [chemical binding]; other site 881621001564 activation loop (A-loop); other site 881621001565 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 881621001566 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 881621001567 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 881621001568 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621001569 Coenzyme A binding pocket [chemical binding]; other site 881621001570 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 881621001571 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 881621001572 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 881621001573 DNA binding residues [nucleotide binding] 881621001574 putative dimer interface [polypeptide binding]; other site 881621001575 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 881621001576 active site 881621001577 catalytic triad [active] 881621001578 oxyanion hole [active] 881621001579 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 881621001580 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 881621001581 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 881621001582 active site turn [active] 881621001583 phosphorylation site [posttranslational modification] 881621001584 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 881621001585 HPr interaction site; other site 881621001586 glycerol kinase (GK) interaction site [polypeptide binding]; other site 881621001587 active site 881621001588 phosphorylation site [posttranslational modification] 881621001589 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 881621001590 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 881621001591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621001592 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 881621001593 AP (apurinic/apyrimidinic) site pocket; other site 881621001594 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 881621001595 DNA interaction; other site 881621001596 Metal-binding active site; metal-binding site 881621001597 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 881621001598 Helix-turn-helix domains; Region: HTH; cl00088 881621001599 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 881621001600 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 881621001601 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621001602 Helix-turn-helix domains; Region: HTH; cl00088 881621001603 ATP synthase subunit C; Region: ATP-synt_C; cl00466 881621001604 weakly similar to ATP synthase delta chain,N-terminal part 881621001605 weakly similar to ATP synthase delta chain,C-terminal part 881621001606 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 881621001607 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621001608 Walker A motif; other site 881621001609 ATP binding site [chemical binding]; other site 881621001610 Walker B motif; other site 881621001611 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 881621001612 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 881621001613 ATP synthase; Region: ATP-synt; cl00365 881621001614 Similar to ATP synthase beta chain 881621001615 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 881621001616 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621001617 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621001618 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621001619 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621001620 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621001621 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621001622 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621001623 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 881621001624 PRD domain; Region: PRD; cl15445 881621001625 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 881621001626 P-loop; other site 881621001627 active site 881621001628 phosphorylation site [posttranslational modification] 881621001629 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621001630 active site 881621001631 phosphorylation site [posttranslational modification] 881621001632 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621001633 active site 881621001634 phosphorylation site [posttranslational modification] 881621001635 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 881621001636 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 881621001637 P-loop; other site 881621001638 active site 881621001639 phosphorylation site [posttranslational modification] 881621001640 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 881621001641 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 881621001642 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 881621001643 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621001644 motif II; other site 881621001645 Rrf2 family protein; Region: rrf2_super; TIGR00738 881621001646 Helix-turn-helix domains; Region: HTH; cl00088 881621001647 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 881621001648 S-adenosylmethionine binding site [chemical binding]; other site 881621001649 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 881621001650 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 881621001651 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 881621001652 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 881621001653 active site 881621001654 catalytic tetrad [active] 881621001655 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 881621001656 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 881621001657 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621001658 motif II; other site 881621001659 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 881621001660 catalytic residue [active] 881621001661 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 881621001662 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 881621001663 Sulfatase; Region: Sulfatase; cl10460 881621001664 amino acid transporter; Region: 2A0306; TIGR00909 881621001665 Spore germination protein; Region: Spore_permease; cl15802 881621001666 Spore germination protein; Region: Spore_permease; cl15802 881621001667 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 881621001668 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 881621001669 putative metal binding site [ion binding]; other site 881621001670 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 881621001671 active site 881621001672 metal binding site [ion binding]; metal-binding site 881621001673 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 881621001674 Transcriptional regulators [Transcription]; Region: GntR; COG1802 881621001675 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621001676 DNA-binding site [nucleotide binding]; DNA binding site 881621001677 Predicted membrane protein [Function unknown]; Region: COG1511 881621001678 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 881621001679 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 881621001680 linker region; other site 881621001681 ABC-2 type transporter; Region: ABC2_membrane; cl11417 881621001682 Transcriptional regulators [Transcription]; Region: GntR; COG1802 881621001683 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621001684 DNA-binding site [nucleotide binding]; DNA binding site 881621001685 FCD domain; Region: FCD; cl11656 881621001686 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 881621001687 Protein of unknown function (DUF975); Region: DUF975; cl10504 881621001688 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 881621001689 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 881621001690 active site 881621001691 metal binding site [ion binding]; metal-binding site 881621001692 Protein of unknown function (DUF420); Region: DUF420; cl00989 881621001693 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 881621001694 dimer interface [polypeptide binding]; other site 881621001695 substrate binding site [chemical binding]; other site 881621001696 ATP binding site [chemical binding]; other site 881621001697 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 881621001698 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621001699 active site 881621001700 motif I; other site 881621001701 motif II; other site 881621001702 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 881621001703 maltose O-acetyltransferase; Provisional; Region: PRK10092 881621001704 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 881621001705 active site 881621001706 substrate binding site [chemical binding]; other site 881621001707 trimer interface [polypeptide binding]; other site 881621001708 CoA binding site [chemical binding]; other site 881621001709 Protein of unknown function (DUF423); Region: DUF423; cl01008 881621001710 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 881621001711 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 881621001712 Walker A/P-loop; other site 881621001713 ATP binding site [chemical binding]; other site 881621001714 Q-loop/lid; other site 881621001715 ABC transporter signature motif; other site 881621001716 Walker B; other site 881621001717 D-loop; other site 881621001718 H-loop/switch region; other site 881621001719 ABC-2 type transporter; Region: ABC2_membrane; cl11417 881621001720 Protein of unknown function (DUF805); Region: DUF805; cl01224 881621001721 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 881621001722 FliP family; Region: FliP; cl00593 881621001723 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 881621001724 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 881621001725 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 881621001726 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 881621001727 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 881621001728 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 881621001729 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12726 881621001730 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621001731 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 881621001732 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 881621001733 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 881621001734 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 881621001735 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621001736 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 881621001737 flagellar motor protein MotA; Validated; Region: PRK08124 881621001738 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 881621001739 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 881621001740 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 881621001741 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 881621001742 ligand binding site [chemical binding]; other site 881621001743 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 881621001744 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 881621001745 putative metal binding site; other site 881621001746 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 881621001747 binding surface 881621001748 TPR motif; other site 881621001749 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 881621001750 Response regulator receiver domain; Region: Response_reg; pfam00072 881621001751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 881621001752 active site 881621001753 phosphorylation site [posttranslational modification] 881621001754 intermolecular recognition site; other site 881621001755 dimerization interface [polypeptide binding]; other site 881621001756 flagellin; Provisional; Region: PRK12805 881621001757 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 881621001758 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 881621001759 Response regulator receiver domain; Region: Response_reg; pfam00072 881621001760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 881621001761 active site 881621001762 phosphorylation site [posttranslational modification] 881621001763 intermolecular recognition site; other site 881621001764 dimerization interface [polypeptide binding]; other site 881621001765 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 881621001766 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 881621001767 putative binding surface; other site 881621001768 active site 881621001769 P2 response regulator binding domain; Region: P2; pfam07194 881621001770 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 881621001771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621001772 ATP binding site [chemical binding]; other site 881621001773 Mg2+ binding site [ion binding]; other site 881621001774 G-X-G motif; other site 881621001775 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 881621001776 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 881621001777 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 881621001778 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK11911 881621001779 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 881621001780 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 881621001781 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 881621001782 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 881621001783 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 881621001784 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 881621001785 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 881621001786 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 881621001787 flagellar motor switch protein; Reviewed; Region: PRK06782 881621001788 Chemotaxis phosphatase CheX; Region: CheX; cl15816 881621001789 Chemotaxis phosphatase CheX; Region: CheX; cl15816 881621001790 Chemotaxis phosphatase CheX; Region: CheX; cl15816 881621001791 Chemotaxis phosphatase CheX; Region: CheX; cl15816 881621001792 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 881621001793 Protein of unknown function (DUF327); Region: DUF327; cl00753 881621001794 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 881621001795 glycoprotein BALF4; Provisional; Region: PHA03231 881621001796 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 881621001797 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 881621001798 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 881621001799 flagellar capping protein; Validated; Region: fliD; PRK06798 881621001800 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 881621001801 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 881621001802 Flagellar protein FliS; Region: FliS; cl00654 881621001803 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 881621001804 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 881621001805 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 881621001806 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 881621001807 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 881621001808 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 881621001809 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 881621001810 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 881621001811 FliG C-terminal domain; Region: FliG_C; pfam01706 881621001812 flagellar assembly protein H; Validated; Region: fliH; PRK06800 881621001813 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 881621001814 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621001815 Walker A motif; other site 881621001816 ATP binding site [chemical binding]; other site 881621001817 Walker B motif; other site 881621001818 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 881621001819 N-acetyl-D-glucosamine binding site [chemical binding]; other site 881621001820 catalytic residue [active] 881621001821 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 881621001822 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 881621001823 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 881621001824 Helix-turn-helix domains; Region: HTH; cl00088 881621001825 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 881621001826 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621001827 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 881621001828 Walker A/P-loop; other site 881621001829 ATP binding site [chemical binding]; other site 881621001830 Q-loop/lid; other site 881621001831 ABC transporter signature motif; other site 881621001832 Walker B; other site 881621001833 D-loop; other site 881621001834 H-loop/switch region; other site 881621001835 ABC-2 type transporter; Region: ABC2_membrane; cl11417 881621001836 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 881621001837 pyruvate oxidase; Provisional; Region: PRK08611 881621001838 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 881621001839 PYR/PP interface [polypeptide binding]; other site 881621001840 tetramer interface [polypeptide binding]; other site 881621001841 dimer interface [polypeptide binding]; other site 881621001842 TPP binding site [chemical binding]; other site 881621001843 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 881621001844 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 881621001845 TPP-binding site [chemical binding]; other site 881621001846 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 881621001847 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 881621001848 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 881621001849 dimerization interface [polypeptide binding]; other site 881621001850 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 881621001851 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 881621001852 dimer interface [polypeptide binding]; other site 881621001853 putative CheW interface [polypeptide binding]; other site 881621001854 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 881621001855 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 881621001856 putative active site [active] 881621001857 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 881621001858 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 881621001859 glutaminase active site [active] 881621001860 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 881621001861 dimer interface [polypeptide binding]; other site 881621001862 active site 881621001863 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 881621001864 dimer interface [polypeptide binding]; other site 881621001865 active site 881621001866 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 881621001867 active site 881621001868 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 881621001869 GIY-YIG motif/motif A; other site 881621001870 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621001871 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621001872 DNA binding site [nucleotide binding] 881621001873 domain linker motif; other site 881621001874 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 881621001875 ligand binding site [chemical binding]; other site 881621001876 dimerization interface [polypeptide binding]; other site 881621001877 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 881621001878 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 881621001879 substrate binding site [chemical binding]; other site 881621001880 hexamer interface [polypeptide binding]; other site 881621001881 metal binding site [ion binding]; metal-binding site 881621001882 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 881621001883 Protein of unknown function (DUF556); Region: DUF556; cl00822 881621001884 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 881621001885 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 881621001886 active site turn [active] 881621001887 phosphorylation site [posttranslational modification] 881621001888 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 881621001889 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 881621001890 HPr interaction site; other site 881621001891 glycerol kinase (GK) interaction site [polypeptide binding]; other site 881621001892 active site 881621001893 phosphorylation site [posttranslational modification] 881621001894 leucine-rich repeat receptor-like protein kinase; Provisional; Region: PLN00113 881621001895 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 881621001896 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 881621001897 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621001898 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621001899 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 881621001900 Predicted transcriptional regulators [Transcription]; Region: COG1725 881621001901 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621001902 DNA-binding site [nucleotide binding]; DNA binding site 881621001903 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 881621001904 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 881621001905 Walker A/P-loop; other site 881621001906 ATP binding site [chemical binding]; other site 881621001907 Q-loop/lid; other site 881621001908 ABC transporter signature motif; other site 881621001909 Walker B; other site 881621001910 D-loop; other site 881621001911 H-loop/switch region; other site 881621001912 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621001913 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 881621001914 Walker A/P-loop; other site 881621001915 ATP binding site [chemical binding]; other site 881621001916 Q-loop/lid; other site 881621001917 ABC transporter signature motif; other site 881621001918 Walker B; other site 881621001919 D-loop; other site 881621001920 H-loop/switch region; other site 881621001921 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 881621001922 FtsX-like permease family; Region: FtsX; cl15850 881621001923 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621001924 active site 881621001925 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 881621001926 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 881621001927 ligand binding site [chemical binding]; other site 881621001928 Helix-turn-helix domains; Region: HTH; cl00088 881621001929 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 881621001930 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 881621001931 Helix-turn-helix domains; Region: HTH; cl00088 881621001932 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 881621001933 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 881621001934 active site 881621001935 Similar to beta-glucoside-specific PTS system enzyme IIABC (N terminal part) 881621001936 Similar to beta-glucoside-specific PTS system enzyme IIABC, central part 881621001937 Similar to beta-glucoside-specific PTS system enzyme IIABC, c-terminal part 881621001938 similar to putative purine nucleoside phosphorylase, N-terminal part 881621001939 similar to putative purine nucleoside phosphorylase, central part 881621001940 similar to putative purine nucleoside phosphorylase, c-terminal part 881621001941 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 881621001942 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 881621001943 active site 881621001944 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 881621001945 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001946 Gram positive anchor; Region: Gram_pos_anchor; cl15427 881621001947 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 881621001948 Zn binding site [ion binding]; other site 881621001949 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 881621001950 Zn binding site [ion binding]; other site 881621001951 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 881621001952 Zn binding site [ion binding]; other site 881621001953 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 881621001954 Zn binding site [ion binding]; other site 881621001955 Predicted esterase [General function prediction only]; Region: COG0400 881621001956 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621001957 Flavin Reductases; Region: FlaRed; cl00801 881621001958 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 881621001959 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 881621001960 HflX GTPase family; Region: HflX; cd01878 881621001961 G1 box; other site 881621001962 GTP/Mg2+ binding site [chemical binding]; other site 881621001963 Switch I region; other site 881621001964 G2 box; other site 881621001965 G3 box; other site 881621001966 Switch II region; other site 881621001967 G4 box; other site 881621001968 G5 box; other site 881621001969 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 881621001970 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 881621001971 putative active site [active] 881621001972 putative metal binding site [ion binding]; other site 881621001973 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 881621001974 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 881621001975 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 881621001976 Transcriptional regulators [Transcription]; Region: GntR; COG1802 881621001977 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621001978 DNA-binding site [nucleotide binding]; DNA binding site 881621001979 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621001980 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 881621001981 NAD(P) binding site [chemical binding]; other site 881621001982 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 881621001983 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 881621001984 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 881621001985 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 881621001986 VanZ like family; Region: VanZ; cl01971 881621001987 Protein of unknown function (DUF986); Region: DUF986; cl01983 881621001988 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 881621001989 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 881621001990 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 881621001991 active site 881621001992 phosphorylation site [posttranslational modification] 881621001993 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 881621001994 active pocket/dimerization site; other site 881621001995 active site 881621001996 phosphorylation site [posttranslational modification] 881621001997 Helix-turn-helix domains; Region: HTH; cl00088 881621001998 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 881621001999 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621002000 Walker A motif; other site 881621002001 ATP binding site [chemical binding]; other site 881621002002 Walker B motif; other site 881621002003 arginine finger; other site 881621002004 Transcriptional antiterminator [Transcription]; Region: COG3933 881621002005 PRD domain; Region: PRD; cl15445 881621002006 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 881621002007 active pocket/dimerization site; other site 881621002008 active site 881621002009 phosphorylation site [posttranslational modification] 881621002010 PRD domain; Region: PRD; cl15445 881621002011 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 881621002012 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 881621002013 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 881621002014 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 881621002015 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 881621002016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 881621002017 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 881621002018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 881621002019 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 881621002020 putative deacylase active site [active] 881621002021 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 881621002022 Protein of unknown function (DUF554); Region: DUF554; cl00784 881621002023 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 881621002024 NADH(P)-binding; Region: NAD_binding_10; pfam13460 881621002025 NAD binding site [chemical binding]; other site 881621002026 putative active site [active] 881621002027 substrate binding site [chemical binding]; other site 881621002028 Predicted permeases [General function prediction only]; Region: RarD; COG2962 881621002029 EamA-like transporter family; Region: EamA; cl01037 881621002030 YceI-like domain; Region: YceI; cl01001 881621002031 Transcriptional regulators [Transcription]; Region: MarR; COG1846 881621002032 Helix-turn-helix domains; Region: HTH; cl00088 881621002033 lysine transporter; Provisional; Region: PRK10836 881621002034 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 881621002035 PAS domain; Region: PAS_9; pfam13426 881621002036 putative active site [active] 881621002037 heme pocket [chemical binding]; other site 881621002038 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 881621002039 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 881621002040 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 881621002041 synthetase active site [active] 881621002042 NTP binding site [chemical binding]; other site 881621002043 metal binding site [ion binding]; metal-binding site 881621002044 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 881621002045 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 881621002046 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621002047 non-specific DNA binding site [nucleotide binding]; other site 881621002048 salt bridge; other site 881621002049 sequence-specific DNA binding site [nucleotide binding]; other site 881621002050 Cupin domain; Region: Cupin_2; cl09118 881621002051 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 881621002052 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 881621002053 Walker A/P-loop; other site 881621002054 ATP binding site [chemical binding]; other site 881621002055 Q-loop/lid; other site 881621002056 ABC transporter signature motif; other site 881621002057 Walker B; other site 881621002058 D-loop; other site 881621002059 H-loop/switch region; other site 881621002060 TOBE domain; Region: TOBE_2; cl01440 881621002061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 881621002062 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 881621002063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621002064 dimer interface [polypeptide binding]; other site 881621002065 conserved gate region; other site 881621002066 putative PBP binding loops; other site 881621002067 ABC-ATPase subunit interface; other site 881621002068 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 881621002069 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 881621002070 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 881621002071 similar to transcription regulator (C-terminal part) 881621002072 Similar to transcription regulator (N-terminal part) 881621002073 similar to unknown protein, C-terminal part 881621002074 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 881621002075 active site 881621002076 zinc binding site [ion binding]; other site 881621002077 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 881621002078 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 881621002079 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 881621002080 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 881621002081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 881621002082 active site 881621002083 phosphorylation site [posttranslational modification] 881621002084 intermolecular recognition site; other site 881621002085 dimerization interface [polypeptide binding]; other site 881621002086 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 881621002087 DNA binding site [nucleotide binding] 881621002088 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 881621002089 dimerization interface [polypeptide binding]; other site 881621002090 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 881621002091 dimer interface [polypeptide binding]; other site 881621002092 phosphorylation site [posttranslational modification] 881621002093 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621002094 ATP binding site [chemical binding]; other site 881621002095 Mg2+ binding site [ion binding]; other site 881621002096 G-X-G motif; other site 881621002097 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 881621002098 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621002099 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 881621002100 Walker A/P-loop; other site 881621002101 ATP binding site [chemical binding]; other site 881621002102 Q-loop/lid; other site 881621002103 ABC transporter signature motif; other site 881621002104 Walker B; other site 881621002105 D-loop; other site 881621002106 H-loop/switch region; other site 881621002107 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 881621002108 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 881621002109 FMN binding site [chemical binding]; other site 881621002110 substrate binding site [chemical binding]; other site 881621002111 putative catalytic residue [active] 881621002112 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 881621002113 dimer interface [polypeptide binding]; other site 881621002114 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 881621002115 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 881621002116 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 881621002117 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 881621002118 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 881621002119 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621002120 motif II; other site 881621002121 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 881621002122 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 881621002123 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 881621002124 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 881621002125 DNA binding residues [nucleotide binding] 881621002126 putative dimer interface [polypeptide binding]; other site 881621002127 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 881621002128 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 881621002129 active site 881621002130 catalytic tetrad [active] 881621002131 similar to internalin, putative peptidoglycan linked protein (LPXTG motif), C-terminal part 881621002132 similar to internalin, putative peptidoglycan linked protein (LPXTG motif), N-terminal part 881621002133 similar to Putative peptidoglycan linked protein (LPXTG motif), N-terminal part 881621002134 similar to Putative peptidoglycan linked protein (LPXTG motif), C-terminal part 881621002135 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 881621002136 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 881621002137 homodimer interface [polypeptide binding]; other site 881621002138 NAD binding site [chemical binding]; other site 881621002139 catalytic residues [active] 881621002140 substrate binding pocket [chemical binding]; other site 881621002141 flexible flap; other site 881621002142 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 881621002143 active site 881621002144 substrate binding site [chemical binding]; other site 881621002145 trimer interface [polypeptide binding]; other site 881621002146 CoA binding site [chemical binding]; other site 881621002147 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 881621002148 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 881621002149 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 881621002150 PhoU domain; Region: PhoU; pfam01895 881621002151 PhoU domain; Region: PhoU; pfam01895 881621002152 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 881621002153 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 881621002154 dimer interface [polypeptide binding]; other site 881621002155 PYR/PP interface [polypeptide binding]; other site 881621002156 TPP binding site [chemical binding]; other site 881621002157 substrate binding site [chemical binding]; other site 881621002158 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 881621002159 Domain of unknown function; Region: EKR; cl11037 881621002160 4Fe-4S binding domain; Region: Fer4; cl02805 881621002161 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 881621002162 TPP-binding site [chemical binding]; other site 881621002163 dimer interface [polypeptide binding]; other site 881621002164 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 881621002165 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 881621002166 Membrane transport protein; Region: Mem_trans; cl09117 881621002167 Phosphate-starvation-inducible E; Region: PsiE; cl01264 881621002168 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 881621002169 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 881621002170 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 881621002171 Walker A/P-loop; other site 881621002172 ATP binding site [chemical binding]; other site 881621002173 Q-loop/lid; other site 881621002174 ABC transporter signature motif; other site 881621002175 Walker B; other site 881621002176 D-loop; other site 881621002177 H-loop/switch region; other site 881621002178 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 881621002179 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621002180 putative substrate translocation pore; other site 881621002181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621002182 putative substrate translocation pore; other site 881621002183 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 881621002184 Helix-turn-helix domains; Region: HTH; cl00088 881621002185 Transcriptional regulator [Transcription]; Region: LysR; COG0583 881621002186 Helix-turn-helix domains; Region: HTH; cl00088 881621002187 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 881621002188 dimerization interface [polypeptide binding]; other site 881621002189 EamA-like transporter family; Region: EamA; cl01037 881621002190 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 881621002191 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 881621002192 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 881621002193 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 881621002194 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 881621002195 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 881621002196 similar to unknown protein (N-terminal part) 881621002197 similar to unknown protein (C-terminal part) 881621002198 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 881621002199 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 881621002200 homotrimer interaction site [polypeptide binding]; other site 881621002201 putative active site [active] 881621002202 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 881621002203 substrate binding site [chemical binding]; other site 881621002204 zinc-binding site [ion binding]; other site 881621002205 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 881621002206 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 881621002207 GIY-YIG motif/motif A; other site 881621002208 active site 881621002209 catalytic site [active] 881621002210 putative DNA binding site [nucleotide binding]; other site 881621002211 metal binding site [ion binding]; metal-binding site 881621002212 UvrB/uvrC motif; Region: UVR; pfam02151 881621002213 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 881621002214 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 881621002215 substrate binding pocket [chemical binding]; other site 881621002216 membrane-bound complex binding site; other site 881621002217 hinge residues; other site 881621002218 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 881621002219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621002220 dimer interface [polypeptide binding]; other site 881621002221 conserved gate region; other site 881621002222 putative PBP binding loops; other site 881621002223 ABC-ATPase subunit interface; other site 881621002224 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 881621002225 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 881621002226 Walker A/P-loop; other site 881621002227 ATP binding site [chemical binding]; other site 881621002228 Q-loop/lid; other site 881621002229 ABC transporter signature motif; other site 881621002230 Walker B; other site 881621002231 D-loop; other site 881621002232 H-loop/switch region; other site 881621002233 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621002234 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 881621002235 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 881621002236 partial 881621002237 similar to internalin, putative peptidoglycan linked protein (LPXTG motif) 881621002238 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 881621002239 Helix-turn-helix domains; Region: HTH; cl00088 881621002240 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 881621002241 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 881621002242 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 881621002243 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 881621002244 ATP-grasp domain; Region: ATP-grasp_4; cl03087 881621002245 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 881621002246 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 881621002247 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 881621002248 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 881621002249 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 881621002250 Esterase/lipase [General function prediction only]; Region: COG1647 881621002251 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621002252 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621002253 DNA binding site [nucleotide binding] 881621002254 domain linker motif; other site 881621002255 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 881621002256 putative dimerization interface [polypeptide binding]; other site 881621002257 putative ligand binding site [chemical binding]; other site 881621002258 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 881621002259 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 881621002260 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 881621002261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621002262 dimer interface [polypeptide binding]; other site 881621002263 conserved gate region; other site 881621002264 putative PBP binding loops; other site 881621002265 ABC-ATPase subunit interface; other site 881621002266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621002267 dimer interface [polypeptide binding]; other site 881621002268 conserved gate region; other site 881621002269 ABC-ATPase subunit interface; other site 881621002270 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 881621002271 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 881621002272 Ca binding site [ion binding]; other site 881621002273 active site 881621002274 catalytic site [active] 881621002275 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 881621002276 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 881621002277 active site 881621002278 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 881621002279 active site 881621002280 substrate binding site [chemical binding]; other site 881621002281 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 881621002282 metal binding site [ion binding]; metal-binding site 881621002283 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 881621002284 DEAD-like helicases superfamily; Region: DEXDc; smart00487 881621002285 ATP binding site [chemical binding]; other site 881621002286 Mg++ binding site [ion binding]; other site 881621002287 motif III; other site 881621002288 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621002289 nucleotide binding region [chemical binding]; other site 881621002290 Hef nuclease; Provisional; Region: PRK13766 881621002291 ATP-binding site [chemical binding]; other site 881621002292 Viral enhancin protein; Region: Enhancin; pfam03272 881621002293 Peptidase M60-like family; Region: M60-like; pfam13402 881621002294 Viral enhancin protein; Region: Enhancin; pfam03272 881621002295 Viral enhancin protein; Region: Enhancin; pfam03272 881621002296 Peptidase M60-like family; Region: M60-like; pfam13402 881621002297 Viral enhancin protein; Region: Enhancin; pfam03272 881621002298 Viral enhancin protein; Region: Enhancin; pfam03272 881621002299 Viral enhancin protein; Region: Enhancin; pfam03272 881621002300 QueT transporter; Region: QueT; cl01932 881621002301 similar to unknown protein (C-terminal part) 881621002302 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 881621002303 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 881621002304 PRD domain; Region: PRD; cl15445 881621002305 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 881621002306 P-loop; other site 881621002307 active site 881621002308 phosphorylation site [posttranslational modification] 881621002309 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621002310 active site 881621002311 phosphorylation site [posttranslational modification] 881621002312 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 881621002313 methionine cluster; other site 881621002314 active site 881621002315 phosphorylation site [posttranslational modification] 881621002316 metal binding site [ion binding]; metal-binding site 881621002317 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 881621002318 active site 881621002319 P-loop; other site 881621002320 phosphorylation site [posttranslational modification] 881621002321 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 881621002322 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 881621002323 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 881621002324 active site 881621002325 trimer interface [polypeptide binding]; other site 881621002326 allosteric site; other site 881621002327 active site lid [active] 881621002328 hexamer (dimer of trimers) interface [polypeptide binding]; other site 881621002329 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 881621002330 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 881621002331 active site 881621002332 catalytic tetrad [active] 881621002333 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 881621002334 Bacterial PH domain; Region: DUF304; cl01348 881621002335 Predicted membrane protein [Function unknown]; Region: COG3428 881621002336 Bacterial PH domain; Region: DUF304; cl01348 881621002337 Bacterial PH domain; Region: DUF304; cl01348 881621002338 Bacterial PH domain; Region: DUF304; cl01348 881621002339 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 881621002340 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 881621002341 alanine racemase; Reviewed; Region: alr; PRK00053 881621002342 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 881621002343 active site 881621002344 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 881621002345 dimer interface [polypeptide binding]; other site 881621002346 substrate binding site [chemical binding]; other site 881621002347 catalytic residues [active] 881621002348 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 881621002349 PemK-like protein; Region: PemK; cl00995 881621002350 Rsbr N terminal; Region: Rsbr_N; pfam08678 881621002351 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 881621002352 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 881621002353 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 881621002354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 881621002355 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 881621002356 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 881621002357 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 881621002358 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 881621002359 anti sigma factor interaction site; other site 881621002360 regulatory phosphorylation site [posttranslational modification]; other site 881621002361 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 881621002362 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621002363 ATP binding site [chemical binding]; other site 881621002364 Mg2+ binding site [ion binding]; other site 881621002365 G-X-G motif; other site 881621002366 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 881621002367 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 881621002368 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 881621002369 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 881621002370 DNA binding residues [nucleotide binding] 881621002371 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 881621002372 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 881621002373 Sulfate transporter family; Region: Sulfate_transp; cl15842 881621002374 putative transporter; Provisional; Region: PRK11660 881621002375 Sulfate transporter family; Region: Sulfate_transp; cl15842 881621002376 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 881621002377 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 881621002378 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 881621002379 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 881621002380 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 881621002381 RNA binding site [nucleotide binding]; other site 881621002382 hypothetical protein; Provisional; Region: PRK04351 881621002383 SprT homologues; Region: SprT; cl01182 881621002384 Protein of unknown function (DUF419); Region: DUF419; cl15265 881621002385 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 881621002386 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 881621002387 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 881621002388 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621002389 DNA-binding site [nucleotide binding]; DNA binding site 881621002390 UTRA domain; Region: UTRA; cl01230 881621002391 OsmC-like protein; Region: OsmC; cl00767 881621002392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 881621002393 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 881621002394 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 881621002395 glutathione reductase; Validated; Region: PRK06116 881621002396 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 881621002397 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 881621002398 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621002399 catalytic core [active] 881621002400 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 881621002401 Domain of unknown function DUF20; Region: UPF0118; pfam01594 881621002402 Predicted transcriptional regulators [Transcription]; Region: COG1725 881621002403 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621002404 DNA-binding site [nucleotide binding]; DNA binding site 881621002405 Predicted membrane protein [General function prediction only]; Region: COG4194 881621002406 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 881621002407 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 881621002408 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 881621002409 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 881621002410 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 881621002411 tetramerization interface [polypeptide binding]; other site 881621002412 NAD(P) binding site [chemical binding]; other site 881621002413 catalytic residues [active] 881621002414 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 881621002415 P-loop; other site 881621002416 active site 881621002417 phosphorylation site [posttranslational modification] 881621002418 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 881621002419 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 881621002420 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 881621002421 methionine cluster; other site 881621002422 active site 881621002423 phosphorylation site [posttranslational modification] 881621002424 metal binding site [ion binding]; metal-binding site 881621002425 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 881621002426 Helix-turn-helix domains; Region: HTH; cl00088 881621002427 PRD domain; Region: PRD; cl15445 881621002428 PRD domain; Region: PRD; cl15445 881621002429 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621002430 active site 881621002431 phosphorylation site [posttranslational modification] 881621002432 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 881621002433 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 881621002434 ABC transporter; Region: ABC_tran_2; pfam12848 881621002435 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 881621002436 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 881621002437 Predicted permeases [General function prediction only]; Region: COG0701 881621002438 Predicted permease; Region: DUF318; pfam03773 881621002439 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 881621002440 pantothenate kinase; Provisional; Region: PRK05439 881621002441 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 881621002442 ATP-binding site [chemical binding]; other site 881621002443 CoA-binding site [chemical binding]; other site 881621002444 Mg2+-binding site [ion binding]; other site 881621002445 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 881621002446 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 881621002447 Walker A/P-loop; other site 881621002448 ATP binding site [chemical binding]; other site 881621002449 Q-loop/lid; other site 881621002450 ABC transporter signature motif; other site 881621002451 Walker B; other site 881621002452 D-loop; other site 881621002453 H-loop/switch region; other site 881621002454 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 881621002455 ABC-2 type transporter; Region: ABC2_membrane; cl11417 881621002456 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 881621002457 Helix-turn-helix domains; Region: HTH; cl00088 881621002458 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 881621002459 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 881621002460 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 881621002461 Sulfatase; Region: Sulfatase; cl10460 881621002462 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 881621002463 active site 881621002464 DNA binding site [nucleotide binding] 881621002465 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 881621002466 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 881621002467 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 881621002468 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 881621002469 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 881621002470 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 881621002471 Ligand binding site; other site 881621002472 Putative Catalytic site; other site 881621002473 DXD motif; other site 881621002474 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 881621002475 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 881621002476 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 881621002477 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 881621002478 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 881621002479 HEAT repeats; Region: HEAT_2; pfam13646 881621002480 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 881621002481 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 881621002482 dimer interface [polypeptide binding]; other site 881621002483 FMN binding site [chemical binding]; other site 881621002484 NADPH bind site [chemical binding]; other site 881621002485 Low molecular weight phosphatase family; Region: LMWPc; cd00115 881621002486 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 881621002487 active site 881621002488 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 881621002489 similar to heat shock protein HtpG, C-terminal part 881621002490 similar to heat shock protein HtpG, N-terminal part 881621002491 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 881621002492 Ferritin-like domain; Region: Ferritin; pfam00210 881621002493 dimerization interface [polypeptide binding]; other site 881621002494 DPS ferroxidase diiron center [ion binding]; other site 881621002495 ion pore; other site 881621002496 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 881621002497 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 881621002498 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 881621002499 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 881621002500 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 881621002501 hypothetical transport protein, C-terminal part 881621002502 hypothetical transport protein, N-terminal part 881621002503 Transcriptional regulators [Transcription]; Region: FadR; COG2186 881621002504 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621002505 DNA-binding site [nucleotide binding]; DNA binding site 881621002506 FCD domain; Region: FCD; cl11656 881621002507 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 881621002508 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 881621002509 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621002510 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621002511 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 881621002512 Helix-turn-helix domains; Region: HTH; cl00088 881621002513 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 881621002514 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 881621002515 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 881621002516 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 881621002517 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 881621002518 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 881621002519 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 881621002520 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 881621002521 active site 881621002522 dimer interface [polypeptide binding]; other site 881621002523 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 881621002524 active site 881621002525 trimer interface [polypeptide binding]; other site 881621002526 allosteric site; other site 881621002527 active site lid [active] 881621002528 hexamer (dimer of trimers) interface [polypeptide binding]; other site 881621002529 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 881621002530 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621002531 DNA-binding site [nucleotide binding]; DNA binding site 881621002532 UTRA domain; Region: UTRA; cl01230 881621002533 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 881621002534 Mg++ binding site [ion binding]; other site 881621002535 putative catalytic motif [active] 881621002536 substrate binding site [chemical binding]; other site 881621002537 Radical SAM superfamily; Region: Radical_SAM; pfam04055 881621002538 Peptidase family U32; Region: Peptidase_U32; cl03113 881621002539 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 881621002540 Peptidase family U32; Region: Peptidase_U32; cl03113 881621002541 LemA family; Region: LemA; cl00742 881621002542 Peptidase family M48; Region: Peptidase_M48; cl12018 881621002543 similar to ABC transporter (ATP-binding protein),C-terminal part 881621002544 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 881621002545 Thioredoxin; Region: Thioredoxin_5; pfam13743 881621002546 catalytic residues [active] 881621002547 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 881621002548 putative active site [active] 881621002549 putative metal binding residues [ion binding]; other site 881621002550 signature motif; other site 881621002551 putative triphosphate binding site [ion binding]; other site 881621002552 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 881621002553 TPR motif; other site 881621002554 binding surface 881621002555 Tetratrico peptide repeat; Region: TPR_5; pfam12688 881621002556 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 881621002557 synthetase active site [active] 881621002558 NTP binding site [chemical binding]; other site 881621002559 metal binding site [ion binding]; metal-binding site 881621002560 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 881621002561 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 881621002562 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 881621002563 active site 881621002564 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 881621002565 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 881621002566 NAD binding site [chemical binding]; other site 881621002567 homotetramer interface [polypeptide binding]; other site 881621002568 homodimer interface [polypeptide binding]; other site 881621002569 substrate binding site [chemical binding]; other site 881621002570 active site 881621002571 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 881621002572 DltD N-terminal region; Region: DltD_N; pfam04915 881621002573 DltD central region; Region: DltD_M; pfam04918 881621002574 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 881621002575 Phosphopantetheine attachment site; Region: PP-binding; cl09936 881621002576 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 881621002577 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 881621002578 AMP-binding enzyme; Region: AMP-binding; cl15778 881621002579 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 881621002580 tetramer (dimer of dimers) interface [polypeptide binding]; other site 881621002581 active site 881621002582 dimer interface [polypeptide binding]; other site 881621002583 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 881621002584 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621002585 Putative esterase; Region: Esterase; pfam00756 881621002586 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 881621002587 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 881621002588 homodimer interface [polypeptide binding]; other site 881621002589 substrate-cofactor binding pocket; other site 881621002590 catalytic residue [active] 881621002591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621002592 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621002593 putative substrate translocation pore; other site 881621002594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621002595 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 881621002596 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 881621002597 putative oligomer interface [polypeptide binding]; other site 881621002598 putative active site [active] 881621002599 metal binding site [ion binding]; metal-binding site 881621002600 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 881621002601 catalytic residues [active] 881621002602 dimer interface [polypeptide binding]; other site 881621002603 LytTr DNA-binding domain; Region: LytTR; cl04498 881621002604 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 881621002605 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621002606 Walker A/P-loop; other site 881621002607 ATP binding site [chemical binding]; other site 881621002608 Q-loop/lid; other site 881621002609 ABC transporter signature motif; other site 881621002610 Walker B; other site 881621002611 D-loop; other site 881621002612 H-loop/switch region; other site 881621002613 ABC-2 type transporter; Region: ABC2_membrane; cl11417 881621002614 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 881621002615 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 881621002616 G1 box; other site 881621002617 putative GEF interaction site [polypeptide binding]; other site 881621002618 GTP/Mg2+ binding site [chemical binding]; other site 881621002619 Switch I region; other site 881621002620 G2 box; other site 881621002621 G3 box; other site 881621002622 Switch II region; other site 881621002623 G4 box; other site 881621002624 G5 box; other site 881621002625 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 881621002626 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 881621002627 Helix-turn-helix domains; Region: HTH; cl00088 881621002628 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 881621002629 MatE; Region: MatE; cl10513 881621002630 Integral membrane protein TerC family; Region: TerC; cl10468 881621002631 Integral membrane protein TerC family; Region: TerC; cl10468 881621002632 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 881621002633 Cation transport protein; Region: TrkH; cl10514 881621002634 OpgC protein; Region: OpgC_C; cl00792 881621002635 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 881621002636 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 881621002637 DNA binding site [nucleotide binding] 881621002638 active site 881621002639 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 881621002640 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621002641 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 881621002642 Walker A motif; other site 881621002643 ATP binding site [chemical binding]; other site 881621002644 Walker B motif; other site 881621002645 arginine finger; other site 881621002646 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 881621002647 UvrB/uvrC motif; Region: UVR; pfam02151 881621002648 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621002649 Walker A motif; other site 881621002650 ATP binding site [chemical binding]; other site 881621002651 Walker B motif; other site 881621002652 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 881621002653 CAAX protease self-immunity; Region: Abi; cl00558 881621002654 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 881621002655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621002656 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 881621002657 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 881621002658 dimerization domain swap beta strand [polypeptide binding]; other site 881621002659 regulatory protein interface [polypeptide binding]; other site 881621002660 active site 881621002661 regulatory phosphorylation site [posttranslational modification]; other site 881621002662 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 881621002663 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 881621002664 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 881621002665 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 881621002666 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 881621002667 putative active site [active] 881621002668 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 881621002669 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621002670 aminotransferase A; Validated; Region: PRK07683 881621002671 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 881621002672 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621002673 homodimer interface [polypeptide binding]; other site 881621002674 catalytic residue [active] 881621002675 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 881621002676 FOG: CBS domain [General function prediction only]; Region: COG0517 881621002677 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 881621002678 Transcriptional regulator [Transcription]; Region: LysR; COG0583 881621002679 Helix-turn-helix domains; Region: HTH; cl00088 881621002680 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 881621002681 dimerization interface [polypeptide binding]; other site 881621002682 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 881621002683 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 881621002684 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 881621002685 trimer interface [polypeptide binding]; other site 881621002686 active site 881621002687 substrate binding site [chemical binding]; other site 881621002688 CoA binding site [chemical binding]; other site 881621002689 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 881621002690 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 881621002691 metal binding site [ion binding]; metal-binding site 881621002692 putative dimer interface [polypeptide binding]; other site 881621002693 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 881621002694 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 881621002695 Mechanosensitive ion channel; Region: MS_channel; pfam00924 881621002696 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 881621002697 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621002698 Walker A/P-loop; other site 881621002699 ATP binding site [chemical binding]; other site 881621002700 Q-loop/lid; other site 881621002701 ABC transporter signature motif; other site 881621002702 Walker B; other site 881621002703 D-loop; other site 881621002704 H-loop/switch region; other site 881621002705 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 881621002706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621002707 dimer interface [polypeptide binding]; other site 881621002708 conserved gate region; other site 881621002709 putative PBP binding loops; other site 881621002710 ABC-ATPase subunit interface; other site 881621002711 NMT1-like family; Region: NMT1_2; cl15260 881621002712 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 881621002713 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 881621002714 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 881621002715 HPr interaction site; other site 881621002716 glycerol kinase (GK) interaction site [polypeptide binding]; other site 881621002717 active site 881621002718 phosphorylation site [posttranslational modification] 881621002719 CutC family; Region: CutC; cl01218 881621002720 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 881621002721 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 881621002722 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 881621002723 Predicted membrane protein [Function unknown]; Region: COG4758 881621002724 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 881621002725 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 881621002726 Histidine kinase; Region: HisKA_3; pfam07730 881621002727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621002728 ATP binding site [chemical binding]; other site 881621002729 Mg2+ binding site [ion binding]; other site 881621002730 G-X-G motif; other site 881621002731 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 881621002732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 881621002733 active site 881621002734 phosphorylation site [posttranslational modification] 881621002735 intermolecular recognition site; other site 881621002736 dimerization interface [polypeptide binding]; other site 881621002737 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 881621002738 DNA binding residues [nucleotide binding] 881621002739 dimerization interface [polypeptide binding]; other site 881621002740 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 881621002741 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621002742 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 881621002743 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 881621002744 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 881621002745 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 881621002746 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 881621002747 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 881621002748 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 881621002749 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 881621002750 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621002751 active site 881621002752 motif I; other site 881621002753 motif II; other site 881621002754 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621002755 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621002756 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621002757 DNA binding site [nucleotide binding] 881621002758 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 881621002759 ligand binding site [chemical binding]; other site 881621002760 dimerization interface [polypeptide binding]; other site 881621002761 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 881621002762 hexamer (dimer of trimers) interface [polypeptide binding]; other site 881621002763 trimer interface [polypeptide binding]; other site 881621002764 substrate binding site [chemical binding]; other site 881621002765 Mn binding site [ion binding]; other site 881621002766 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 881621002767 TPP-binding site [chemical binding]; other site 881621002768 dimer interface [polypeptide binding]; other site 881621002769 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 881621002770 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 881621002771 PYR/PP interface [polypeptide binding]; other site 881621002772 dimer interface [polypeptide binding]; other site 881621002773 TPP binding site [chemical binding]; other site 881621002774 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 881621002775 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 881621002776 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 881621002777 N- and C-terminal domain interface [polypeptide binding]; other site 881621002778 active site 881621002779 MgATP binding site [chemical binding]; other site 881621002780 catalytic site [active] 881621002781 metal binding site [ion binding]; metal-binding site 881621002782 carbohydrate binding site [chemical binding]; other site 881621002783 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 881621002784 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 881621002785 active site turn [active] 881621002786 phosphorylation site [posttranslational modification] 881621002787 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 881621002788 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 881621002789 HPr interaction site; other site 881621002790 glycerol kinase (GK) interaction site [polypeptide binding]; other site 881621002791 active site 881621002792 phosphorylation site [posttranslational modification] 881621002793 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 881621002794 Protein of unknown function (DUF817); Region: DUF817; cl01520 881621002795 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 881621002796 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 881621002797 GTP binding site; other site 881621002798 ModC is an ABC-type transporter and the ATPase component of a molybdate transport system that also includes the periplasmic binding protein ModA and the membrane protein ModB. ABC transporters are a large family of proteins involved in the transport of a...; Region: ABC_ModC_molybdenum_transporter; cd03297 881621002799 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 881621002800 Walker A/P-loop; other site 881621002801 ATP binding site [chemical binding]; other site 881621002802 Q-loop/lid; other site 881621002803 ABC transporter signature motif; other site 881621002804 Walker B; other site 881621002805 D-loop; other site 881621002806 H-loop/switch region; other site 881621002807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621002808 dimer interface [polypeptide binding]; other site 881621002809 conserved gate region; other site 881621002810 putative PBP binding loops; other site 881621002811 ABC-ATPase subunit interface; other site 881621002812 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 881621002813 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 881621002814 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 881621002815 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 881621002816 dimer interface [polypeptide binding]; other site 881621002817 putative functional site; other site 881621002818 putative MPT binding site; other site 881621002819 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 881621002820 Walker A motif; other site 881621002821 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 881621002822 MoaE homodimer interface [polypeptide binding]; other site 881621002823 MoaD interaction [polypeptide binding]; other site 881621002824 active site residues [active] 881621002825 similar to molybdopterin converting factor (subunit 1), C-terminal part 881621002826 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 881621002827 trimer interface [polypeptide binding]; other site 881621002828 dimer interface [polypeptide binding]; other site 881621002829 putative active site [active] 881621002830 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 881621002831 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 881621002832 FeS/SAM binding site; other site 881621002833 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 881621002834 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 881621002835 MPT binding site; other site 881621002836 trimer interface [polypeptide binding]; other site 881621002837 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 881621002838 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 881621002839 ATP binding site [chemical binding]; other site 881621002840 substrate interface [chemical binding]; other site 881621002841 similar to unknown protein, N-terminal part 881621002842 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 881621002843 active site 881621002844 catalytic residues [active] 881621002845 metal binding site [ion binding]; metal-binding site 881621002846 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 881621002847 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 881621002848 TPP-binding site [chemical binding]; other site 881621002849 tetramer interface [polypeptide binding]; other site 881621002850 heterodimer interface [polypeptide binding]; other site 881621002851 phosphorylation loop region [posttranslational modification] 881621002852 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 881621002853 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 881621002854 alpha subunit interface [polypeptide binding]; other site 881621002855 TPP binding site [chemical binding]; other site 881621002856 heterodimer interface [polypeptide binding]; other site 881621002857 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 881621002858 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 881621002859 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 881621002860 E3 interaction surface; other site 881621002861 lipoyl attachment site [posttranslational modification]; other site 881621002862 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 881621002863 E3 interaction surface; other site 881621002864 lipoyl attachment site [posttranslational modification]; other site 881621002865 e3 binding domain; Region: E3_binding; pfam02817 881621002866 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 881621002867 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 881621002868 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621002869 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 881621002870 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 881621002871 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 881621002872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621002873 NAD(P) binding site [chemical binding]; other site 881621002874 LDH/MDH dimer interface [polypeptide binding]; other site 881621002875 substrate binding site [chemical binding]; other site 881621002876 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 881621002877 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 881621002878 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 881621002879 Probable galacturonosyltransferase; Region: PLN02867 881621002880 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 881621002881 Protein of unknown function (DUF1054); Region: DUF1054; cl11544 881621002882 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 881621002883 active site 881621002884 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 881621002885 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 881621002886 G1 box; other site 881621002887 putative GEF interaction site [polypeptide binding]; other site 881621002888 GTP/Mg2+ binding site [chemical binding]; other site 881621002889 Switch I region; other site 881621002890 G2 box; other site 881621002891 G3 box; other site 881621002892 Switch II region; other site 881621002893 G4 box; other site 881621002894 G5 box; other site 881621002895 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 881621002896 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 881621002897 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 881621002898 amidase catalytic site [active] 881621002899 Zn binding residues [ion binding]; other site 881621002900 substrate binding site [chemical binding]; other site 881621002901 Bacterial SH3 domain; Region: SH3_3; cl02551 881621002902 Bacterial SH3 domain; Region: SH3_3; cl02551 881621002903 Bacterial SH3 domain; Region: SH3_3; cl02551 881621002904 Bacterial SH3 domain; Region: SH3_3; cl02551 881621002905 Bacterial SH3 domain; Region: SH3_3; cl02551 881621002906 Bacterial SH3 domain; Region: SH3_3; cl02551 881621002907 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; cl11558 881621002908 Protein of unknown function (DUF1507); Region: DUF1507; cl11487 881621002909 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 881621002910 pyruvate carboxylase; Reviewed; Region: PRK12999 881621002911 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 881621002912 ATP-grasp domain; Region: ATP-grasp_4; cl03087 881621002913 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 881621002914 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 881621002915 active site 881621002916 catalytic residues [active] 881621002917 metal binding site [ion binding]; metal-binding site 881621002918 homodimer binding site [polypeptide binding]; other site 881621002919 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 881621002920 carboxyltransferase (CT) interaction site; other site 881621002921 biotinylation site [posttranslational modification]; other site 881621002922 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 881621002923 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 881621002924 putative binding site residues; other site 881621002925 ABC-2 type transporter; Region: ABC2_membrane; cl11417 881621002926 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 881621002927 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 881621002928 Walker A/P-loop; other site 881621002929 ATP binding site [chemical binding]; other site 881621002930 Q-loop/lid; other site 881621002931 ABC transporter signature motif; other site 881621002932 Walker B; other site 881621002933 D-loop; other site 881621002934 H-loop/switch region; other site 881621002935 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 881621002936 Bacterial SH3 domain; Region: SH3_3; cl02551 881621002937 Bacterial SH3 domain; Region: SH3_3; cl02551 881621002938 Bacterial SH3 domain; Region: SH3_3; cl02551 881621002939 Bacterial SH3 domain; Region: SH3_3; cl02551 881621002940 Bacterial SH3 domain; Region: SH3_3; cl02551 881621002941 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 881621002942 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 881621002943 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 881621002944 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 881621002945 Ligand binding site; other site 881621002946 Putative Catalytic site; other site 881621002947 DXD motif; other site 881621002948 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 881621002949 active site 881621002950 tetramer interface; other site 881621002951 putative glycosyltransferase, TIGR03111 family; Region: glyc2_xrt_Gpos1 881621002952 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 881621002953 active site 881621002954 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 881621002955 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 881621002956 substrate binding site; other site 881621002957 dimer interface; other site 881621002958 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 881621002959 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 881621002960 putative NAD(P) binding site [chemical binding]; other site 881621002961 putative catalytic Zn binding site [ion binding]; other site 881621002962 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 881621002963 active site 881621002964 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 881621002965 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 881621002966 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 881621002967 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 881621002968 active site 881621002969 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 881621002970 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 881621002971 homodimer interface [polypeptide binding]; other site 881621002972 NAD binding pocket [chemical binding]; other site 881621002973 ATP binding pocket [chemical binding]; other site 881621002974 Mg binding site [ion binding]; other site 881621002975 active-site loop [active] 881621002976 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 881621002977 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 881621002978 P-loop; other site 881621002979 active site 881621002980 phosphorylation site [posttranslational modification] 881621002981 GMP synthase; Reviewed; Region: guaA; PRK00074 881621002982 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 881621002983 AMP/PPi binding site [chemical binding]; other site 881621002984 candidate oxyanion hole; other site 881621002985 catalytic triad [active] 881621002986 potential glutamine specificity residues [chemical binding]; other site 881621002987 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 881621002988 ATP Binding subdomain [chemical binding]; other site 881621002989 Dimerization subdomain; other site 881621002990 similar to transposase 881621002991 Helix-turn-helix domains; Region: HTH; cl00088 881621002992 Helix-turn-helix domain; Region: HTH_18; pfam12833 881621002993 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621002994 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 881621002995 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 881621002996 active site 881621002997 metal binding site [ion binding]; metal-binding site 881621002998 similar to unknown protein, N-terminal part 881621002999 similar to unknown protein, central part 881621003000 similar to unknown protein, C-terminal part 881621003001 Domain of unknown function (DUF4274); Region: DUF4274; pfam14096 881621003002 similar to unknown protein, partial sequence 881621003003 similar to unknown protein, partial 881621003004 Partial, C-terminal part 881621003005 similar to unknown protein, N-terminal part 881621003006 MepB protein; Region: MepB; cl01985 881621003007 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 881621003008 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 881621003009 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621003010 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 881621003011 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 881621003012 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 881621003013 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 881621003014 DNA binding residues [nucleotide binding] 881621003015 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 881621003016 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 881621003017 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621003018 Walker A/P-loop; other site 881621003019 ATP binding site [chemical binding]; other site 881621003020 Q-loop/lid; other site 881621003021 ABC transporter signature motif; other site 881621003022 Walker B; other site 881621003023 D-loop; other site 881621003024 H-loop/switch region; other site 881621003025 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 881621003026 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 881621003027 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621003028 Walker A/P-loop; other site 881621003029 ATP binding site [chemical binding]; other site 881621003030 Q-loop/lid; other site 881621003031 ABC transporter signature motif; other site 881621003032 Walker B; other site 881621003033 D-loop; other site 881621003034 H-loop/switch region; other site 881621003035 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 881621003036 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 881621003037 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 881621003038 active site turn [active] 881621003039 phosphorylation site [posttranslational modification] 881621003040 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 881621003041 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 881621003042 NAD binding site [chemical binding]; other site 881621003043 sugar binding site [chemical binding]; other site 881621003044 divalent metal binding site [ion binding]; other site 881621003045 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 881621003046 dimer interface [polypeptide binding]; other site 881621003047 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 881621003048 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 881621003049 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 881621003050 putative active site [active] 881621003051 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 881621003052 HPr interaction site; other site 881621003053 glycerol kinase (GK) interaction site [polypeptide binding]; other site 881621003054 active site 881621003055 phosphorylation site [posttranslational modification] 881621003056 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 881621003057 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 881621003058 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 881621003059 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 881621003060 DNA binding residues [nucleotide binding] 881621003061 putative dimer interface [polypeptide binding]; other site 881621003062 weakly similar to inorganic pyrophosphatase,C-terminal part 881621003063 similar to beta-glucosidase, C-terminal part 881621003064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 881621003065 Clp protease; Region: CLP_protease; pfam00574 881621003066 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 881621003067 oligomer interface [polypeptide binding]; other site 881621003068 active site residues [active] 881621003069 similar to unknown protein, C-terminal part 881621003070 similar to unknown protein, N-terminal part 881621003071 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621003072 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 881621003073 Helix-turn-helix domains; Region: HTH; cl00088 881621003074 Bacterial transcriptional repressor; Region: TetR; pfam13972 881621003075 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621003076 short chain dehydrogenase; Provisional; Region: PRK06197 881621003077 NAD(P) binding site [chemical binding]; other site 881621003078 active site 881621003079 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 881621003080 SLBB domain; Region: SLBB; pfam10531 881621003081 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 881621003082 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 881621003083 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 881621003084 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 881621003085 putative hexamer interface [polypeptide binding]; other site 881621003086 putative hexagonal pore; other site 881621003087 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 881621003088 putative hexamer interface [polypeptide binding]; other site 881621003089 putative hexagonal pore; other site 881621003090 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 881621003091 putative hexamer interface [polypeptide binding]; other site 881621003092 putative hexagonal pore; other site 881621003093 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 881621003094 G1 box; other site 881621003095 GTP/Mg2+ binding site [chemical binding]; other site 881621003096 G2 box; other site 881621003097 Switch I region; other site 881621003098 G3 box; other site 881621003099 Switch II region; other site 881621003100 G4 box; other site 881621003101 G5 box; other site 881621003102 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 881621003103 homotrimer interface [polypeptide binding]; other site 881621003104 Walker A motif; other site 881621003105 GTP binding site [chemical binding]; other site 881621003106 Walker B motif; other site 881621003107 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 881621003108 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621003109 catalytic core [active] 881621003110 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 881621003111 Hexamer interface [polypeptide binding]; other site 881621003112 Hexagonal pore residue; other site 881621003113 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutL; COG4816 881621003114 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 881621003115 putative hexamer interface [polypeptide binding]; other site 881621003116 putative hexagonal pore; other site 881621003117 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 881621003118 putative hexamer interface [polypeptide binding]; other site 881621003119 putative hexagonal pore; other site 881621003120 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 881621003121 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 881621003122 alpha-beta subunit interface [polypeptide binding]; other site 881621003123 alpha-gamma subunit interface [polypeptide binding]; other site 881621003124 active site 881621003125 substrate and K+ binding site; other site 881621003126 K+ binding site [ion binding]; other site 881621003127 cobalamin binding site [chemical binding]; other site 881621003128 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 881621003129 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 881621003130 Dehydratase small subunit; Region: Dehydratase_SU; cl02055 881621003131 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 881621003132 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 881621003133 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 881621003134 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 881621003135 putative hexamer interface [polypeptide binding]; other site 881621003136 putative hexagonal pore; other site 881621003137 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 881621003138 Hexamer interface [polypeptide binding]; other site 881621003139 Hexagonal pore residue; other site 881621003140 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 881621003141 Propanediol utilisation protein PduL; Region: PduL; pfam06130 881621003142 Propanediol utilisation protein PduL; Region: PduL; pfam06130 881621003143 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 881621003144 Cell division protein FtsA; Region: FtsA; cl11496 881621003145 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 881621003146 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 881621003147 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 881621003148 Hexamer/Pentamer interface [polypeptide binding]; other site 881621003149 central pore; other site 881621003150 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 881621003151 Domain of unknown function (DUF336); Region: DUF336; cl01249 881621003152 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 881621003153 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 881621003154 putative catalytic cysteine [active] 881621003155 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 881621003156 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 881621003157 putative active site [active] 881621003158 metal binding site [ion binding]; metal-binding site 881621003159 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 881621003160 amphipathic channel; other site 881621003161 Asn-Pro-Ala signature motifs; other site 881621003162 Acetokinase family; Region: Acetate_kinase; cl01029 881621003163 propionate/acetate kinase; Provisional; Region: PRK12379 881621003164 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 881621003165 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 881621003166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621003167 homodimer interface [polypeptide binding]; other site 881621003168 catalytic residue [active] 881621003169 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 881621003170 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 881621003171 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 881621003172 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 881621003173 putative active site [active] 881621003174 metal binding site [ion binding]; metal-binding site 881621003175 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 881621003176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 881621003177 active site 881621003178 phosphorylation site [posttranslational modification] 881621003179 intermolecular recognition site; other site 881621003180 dimerization interface [polypeptide binding]; other site 881621003181 ANTAR domain; Region: ANTAR; cl04297 881621003182 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 881621003183 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 881621003184 Histidine kinase; Region: HisKA_2; cl06527 881621003185 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621003186 ATP binding site [chemical binding]; other site 881621003187 Mg2+ binding site [ion binding]; other site 881621003188 G-X-G motif; other site 881621003189 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 881621003190 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 881621003191 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 881621003192 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 881621003193 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 881621003194 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 881621003195 putative hexamer interface [polypeptide binding]; other site 881621003196 putative hexagonal pore; other site 881621003197 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 881621003198 putative hexamer interface [polypeptide binding]; other site 881621003199 putative hexagonal pore; other site 881621003200 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 881621003201 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 881621003202 Hexamer interface [polypeptide binding]; other site 881621003203 Hexagonal pore residue; other site 881621003204 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 881621003205 putative catalytic cysteine [active] 881621003206 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 881621003207 Hexamer interface [polypeptide binding]; other site 881621003208 Putative hexagonal pore residue; other site 881621003209 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 881621003210 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 881621003211 Propanediol utilisation protein PduL; Region: PduL; pfam06130 881621003212 Propanediol utilisation protein PduL; Region: PduL; pfam06130 881621003213 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 881621003214 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 881621003215 Hexamer/Pentamer interface [polypeptide binding]; other site 881621003216 central pore; other site 881621003217 ethanolamine utilization protein, PduT homolog; Region: eut_PduT; TIGR02526 881621003218 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 881621003219 putative hexamer interface [polypeptide binding]; other site 881621003220 putative hexagonal pore; other site 881621003221 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 881621003222 putative hexamer interface [polypeptide binding]; other site 881621003223 putative hexagonal pore; other site 881621003224 Ethanolamine utilisation protein, EutH; Region: EutH; cl01248 881621003225 Cupin domain; Region: Cupin_2; cl09118 881621003226 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621003227 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 881621003228 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621003229 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 881621003230 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 881621003231 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621003232 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 881621003233 catalytic triad [active] 881621003234 CobD/Cbib protein; Region: CobD_Cbib; cl00561 881621003235 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 881621003236 Precorrin-8X methylmutase; Region: CbiC; pfam02570 881621003237 CbiD; Region: CbiD; cl00828 881621003238 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 881621003239 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 881621003240 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 881621003241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 881621003242 S-adenosylmethionine binding site [chemical binding]; other site 881621003243 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 881621003244 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 881621003245 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 881621003246 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 881621003247 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 881621003248 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 881621003249 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 881621003250 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 881621003251 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 881621003252 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 881621003253 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 881621003254 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 881621003255 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 881621003256 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 881621003257 active site 881621003258 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 881621003259 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 881621003260 active site 881621003261 C-terminal domain interface [polypeptide binding]; other site 881621003262 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 881621003263 active site 881621003264 N-terminal domain interface [polypeptide binding]; other site 881621003265 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 881621003266 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 881621003267 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 881621003268 Cobalt transport protein component CbiN; Region: CbiN; cl00842 881621003269 Cobalt transport protein; Region: CbiQ; cl00463 881621003270 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 881621003271 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 881621003272 Walker A/P-loop; other site 881621003273 ATP binding site [chemical binding]; other site 881621003274 Q-loop/lid; other site 881621003275 ABC transporter signature motif; other site 881621003276 Walker B; other site 881621003277 D-loop; other site 881621003278 H-loop/switch region; other site 881621003279 cobyric acid synthase; Provisional; Region: PRK00784 881621003280 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621003281 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621003282 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 881621003283 catalytic triad [active] 881621003284 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 881621003285 Protein of unknown function, DUF606; Region: DUF606; cl01273 881621003286 Protein of unknown function, DUF606; Region: DUF606; cl01273 881621003287 topology modulation protein; Reviewed; Region: PRK08118 881621003288 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621003289 Helix-turn-helix domains; Region: HTH; cl00088 881621003290 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 881621003291 Predicted transcriptional regulator [Transcription]; Region: COG1959 881621003292 Helix-turn-helix domains; Region: HTH; cl00088 881621003293 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 881621003294 NADH(P)-binding; Region: NAD_binding_10; pfam13460 881621003295 NAD binding site [chemical binding]; other site 881621003296 substrate binding site [chemical binding]; other site 881621003297 putative active site [active] 881621003298 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 881621003299 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 881621003300 SH3-like domain; Region: SH3_8; pfam13457 881621003301 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 881621003302 SH3-like domain; Region: SH3_8; pfam13457 881621003303 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 881621003304 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 881621003305 oligomer interface [polypeptide binding]; other site 881621003306 active site 881621003307 metal binding site [ion binding]; metal-binding site 881621003308 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 881621003309 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 881621003310 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 881621003311 Helix-turn-helix domains; Region: HTH; cl00088 881621003312 Transposase domain (DUF772); Region: DUF772; cl15789 881621003313 Transposase domain (DUF772); Region: DUF772; cl15789 881621003314 Transposase domain (DUF772); Region: DUF772; cl15789 881621003315 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 881621003316 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 881621003317 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 881621003318 dimer interface [polypeptide binding]; other site 881621003319 motif 1; other site 881621003320 active site 881621003321 motif 2; other site 881621003322 motif 3; other site 881621003323 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 881621003324 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 881621003325 putative tRNA-binding site [nucleotide binding]; other site 881621003326 B3/4 domain; Region: B3_4; cl11458 881621003327 tRNA synthetase B5 domain; Region: B5; cl08394 881621003328 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 881621003329 dimer interface [polypeptide binding]; other site 881621003330 motif 1; other site 881621003331 motif 3; other site 881621003332 motif 2; other site 881621003333 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 881621003334 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621003335 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 881621003336 Walker A/P-loop; other site 881621003337 ATP binding site [chemical binding]; other site 881621003338 Q-loop/lid; other site 881621003339 ABC transporter signature motif; other site 881621003340 Walker B; other site 881621003341 D-loop; other site 881621003342 H-loop/switch region; other site 881621003343 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 881621003344 FtsX-like permease family; Region: FtsX; cl15850 881621003345 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 881621003346 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 881621003347 FtsX-like permease family; Region: FtsX; cl15850 881621003348 Transcriptional regulators [Transcription]; Region: MarR; COG1846 881621003349 Helix-turn-helix domains; Region: HTH; cl00088 881621003350 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 881621003351 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 881621003352 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 881621003353 ligand binding site [chemical binding]; other site 881621003354 active site 881621003355 UGI interface [polypeptide binding]; other site 881621003356 catalytic site [active] 881621003357 ribonuclease HIII; Provisional; Region: PRK00996 881621003358 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 881621003359 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 881621003360 RNA/DNA hybrid binding site [nucleotide binding]; other site 881621003361 active site 881621003362 Cell division protein ZapA; Region: ZapA; cl01146 881621003363 Colicin V production protein; Region: Colicin_V; cl00567 881621003364 hypothetical protein; Provisional; Region: PRK08609 881621003365 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 881621003366 active site 881621003367 primer binding site [nucleotide binding]; other site 881621003368 NTP binding site [chemical binding]; other site 881621003369 metal binding triad [ion binding]; metal-binding site 881621003370 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 881621003371 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621003372 Walker A/P-loop; other site 881621003373 ATP binding site [chemical binding]; other site 881621003374 Q-loop/lid; other site 881621003375 ABC transporter signature motif; other site 881621003376 Walker B; other site 881621003377 D-loop; other site 881621003378 H-loop/switch region; other site 881621003379 Smr domain; Region: Smr; cl02619 881621003380 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 881621003381 catalytic residues [active] 881621003382 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 881621003383 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 881621003384 GIY-YIG motif/motif A; other site 881621003385 active site 881621003386 catalytic site [active] 881621003387 putative DNA binding site [nucleotide binding]; other site 881621003388 metal binding site [ion binding]; metal-binding site 881621003389 UvrB/uvrC motif; Region: UVR; pfam02151 881621003390 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 881621003391 aspartate kinase; Reviewed; Region: PRK06635 881621003392 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 881621003393 putative catalytic residues [active] 881621003394 putative nucleotide binding site [chemical binding]; other site 881621003395 putative aspartate binding site [chemical binding]; other site 881621003396 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 881621003397 putative allosteric regulatory site; other site 881621003398 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 881621003399 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 881621003400 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 881621003401 ribonuclease PH; Reviewed; Region: rph; PRK00173 881621003402 Ribonuclease PH; Region: RNase_PH_bact; cd11362 881621003403 hexamer interface [polypeptide binding]; other site 881621003404 active site 881621003405 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003406 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 881621003407 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003408 Leucine-rich repeats; other site 881621003409 Substrate binding site [chemical binding]; other site 881621003410 Leucine rich repeat; Region: LRR_8; pfam13855 881621003411 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003412 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003413 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 881621003414 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003415 SH3-like domain; Region: SH3_8; pfam13457 881621003416 SH3-like domain; Region: SH3_8; pfam13457 881621003417 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003418 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003419 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003420 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003421 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003422 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003423 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 881621003424 Leucine rich repeat; Region: LRR_8; pfam13855 881621003425 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003426 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003427 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 881621003428 Substrate binding site [chemical binding]; other site 881621003429 Leucine-rich repeats; other site 881621003430 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003431 Leucine rich repeat; Region: LRR_8; pfam13855 881621003432 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003433 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003434 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003435 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003436 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003437 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003438 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003439 SH3-like domain; Region: SH3_8; pfam13457 881621003440 SH3-like domain; Region: SH3_8; pfam13457 881621003441 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 881621003442 SH3-like domain; Region: SH3_8; pfam13457 881621003443 SH3-like domain; Region: SH3_8; pfam13457 881621003444 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003445 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 881621003446 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003447 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003448 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003449 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003450 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003451 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003452 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003453 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003454 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003455 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003456 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003457 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003458 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003459 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003460 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003461 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003462 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 881621003463 putative catalytic site [active] 881621003464 metal binding site A [ion binding]; metal-binding site 881621003465 phosphate binding site [ion binding]; other site 881621003466 metal binding site C [ion binding]; metal-binding site 881621003467 metal binding site B [ion binding]; metal-binding site 881621003468 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003469 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 881621003470 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003471 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003472 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003473 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 881621003475 Protein of unknown function (DUF419); Region: DUF419; cl15265 881621003476 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 881621003477 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 881621003478 dimer interface [polypeptide binding]; other site 881621003479 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621003480 catalytic core [active] 881621003481 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 881621003482 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 881621003483 ATP binding site [chemical binding]; other site 881621003484 Mg++ binding site [ion binding]; other site 881621003485 motif III; other site 881621003486 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621003487 nucleotide binding region [chemical binding]; other site 881621003488 ATP-binding site [chemical binding]; other site 881621003489 DbpA RNA binding domain; Region: DbpA; pfam03880 881621003490 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 881621003491 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 881621003492 putative active site [active] 881621003493 nucleotide binding site [chemical binding]; other site 881621003494 nudix motif; other site 881621003495 putative metal binding site [ion binding]; other site 881621003496 Sugar transport protein; Region: Sugar_transport; pfam06800 881621003497 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 881621003498 classical (c) SDRs; Region: SDR_c; cd05233 881621003499 NAD(P) binding site [chemical binding]; other site 881621003500 active site 881621003501 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 881621003502 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 881621003503 DNA binding residues [nucleotide binding] 881621003504 putative dimer interface [polypeptide binding]; other site 881621003505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621003506 putative substrate translocation pore; other site 881621003507 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 881621003508 Helix-turn-helix domains; Region: HTH; cl00088 881621003509 Uncharacterized conserved protein [Function unknown]; Region: COG1284 881621003510 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 881621003511 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 881621003512 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 881621003513 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621003514 DNA-binding site [nucleotide binding]; DNA binding site 881621003515 UTRA domain; Region: UTRA; cl01230 881621003516 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 881621003517 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 881621003518 Ca binding site [ion binding]; other site 881621003519 active site 881621003520 catalytic site [active] 881621003521 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 881621003522 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 881621003523 active site turn [active] 881621003524 phosphorylation site [posttranslational modification] 881621003525 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 881621003526 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 881621003527 nudix motif; other site 881621003528 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 881621003529 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621003530 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 881621003531 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 881621003532 putative catalytic cysteine [active] 881621003533 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 881621003534 nucleotide binding site [chemical binding]; other site 881621003535 homotetrameric interface [polypeptide binding]; other site 881621003536 putative phosphate binding site [ion binding]; other site 881621003537 putative allosteric binding site; other site 881621003538 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 881621003539 Protease prsW family; Region: PrsW-protease; cl15823 881621003540 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621003541 non-specific DNA binding site [nucleotide binding]; other site 881621003542 salt bridge; other site 881621003543 sequence-specific DNA binding site [nucleotide binding]; other site 881621003544 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621003545 non-specific DNA binding site [nucleotide binding]; other site 881621003546 salt bridge; other site 881621003547 sequence-specific DNA binding site [nucleotide binding]; other site 881621003548 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 881621003549 active site 881621003550 trigger factor; Provisional; Region: tig; PRK01490 881621003551 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 881621003552 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 881621003553 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 881621003554 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 881621003555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621003556 Walker A motif; other site 881621003557 ATP binding site [chemical binding]; other site 881621003558 Walker B motif; other site 881621003559 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 881621003560 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 881621003561 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 881621003562 Catalytic site [active] 881621003563 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 881621003564 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 881621003565 Catalytic site [active] 881621003566 conjugative transfer signal peptidase TraF; Region: TraF_Ti; TIGR02771 881621003567 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 881621003568 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 881621003569 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 881621003570 Catalytic site [active] 881621003571 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 881621003572 RNA/DNA hybrid binding site [nucleotide binding]; other site 881621003573 active site 881621003574 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 881621003575 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 881621003576 DNA topoisomerase I; Validated; Region: PRK05582 881621003577 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 881621003578 active site 881621003579 interdomain interaction site; other site 881621003580 putative metal-binding site [ion binding]; other site 881621003581 nucleotide binding site [chemical binding]; other site 881621003582 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 881621003583 domain I; other site 881621003584 DNA binding groove [nucleotide binding] 881621003585 phosphate binding site [ion binding]; other site 881621003586 domain II; other site 881621003587 domain III; other site 881621003588 nucleotide binding site [chemical binding]; other site 881621003589 catalytic site [active] 881621003590 domain IV; other site 881621003591 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 881621003592 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 881621003593 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 881621003594 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621003595 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 881621003596 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 881621003597 DNA binding site [nucleotide binding] 881621003598 Int/Topo IB signature motif; other site 881621003599 active site 881621003600 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 881621003601 active site 881621003602 HslU subunit interaction site [polypeptide binding]; other site 881621003603 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 881621003604 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621003605 Walker A motif; other site 881621003606 ATP binding site [chemical binding]; other site 881621003607 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621003608 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 881621003609 transcriptional repressor CodY; Validated; Region: PRK04158 881621003610 CodY GAF-like domain; Region: CodY; pfam06018 881621003611 Helix-turn-helix domains; Region: HTH; cl00088 881621003612 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 881621003613 active site 881621003614 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 881621003615 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 881621003616 active site 881621003617 catalytic residues [active] 881621003618 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 881621003619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 881621003620 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 881621003621 anchoring element; other site 881621003622 dimer interface [polypeptide binding]; other site 881621003623 ATP binding site [chemical binding]; other site 881621003624 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 881621003625 active site 881621003626 putative metal-binding site [ion binding]; other site 881621003627 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 881621003628 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 881621003629 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 881621003630 CAP-like domain; other site 881621003631 active site 881621003632 primary dimer interface [polypeptide binding]; other site 881621003633 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 881621003634 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 881621003635 OpgC protein; Region: OpgC_C; cl00792 881621003636 Acyltransferase family; Region: Acyl_transf_3; pfam01757 881621003637 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 881621003638 catalytic triad [active] 881621003639 catalytic triad [active] 881621003640 oxyanion hole [active] 881621003641 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 881621003642 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 881621003643 active site 881621003644 catalytic site [active] 881621003645 metal binding site [ion binding]; metal-binding site 881621003646 dimer interface [polypeptide binding]; other site 881621003647 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 881621003648 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621003649 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 881621003650 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 881621003651 Sm1 motif; other site 881621003652 D3 - B interaction site; other site 881621003653 D1 - D2 interaction site; other site 881621003654 Hfq - Hfq interaction site; other site 881621003655 RNA binding pocket [nucleotide binding]; other site 881621003656 Sm2 motif; other site 881621003657 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 881621003658 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 881621003659 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 881621003660 catalytic residue [active] 881621003661 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 881621003662 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 881621003663 DNA binding residues [nucleotide binding] 881621003664 putative dimer interface [polypeptide binding]; other site 881621003665 glutamine synthetase, type I; Region: GlnA; TIGR00653 881621003666 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 881621003667 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 881621003668 arsenical pump membrane protein; Provisional; Region: PRK15445 881621003669 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 881621003670 transmembrane helices; other site 881621003671 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 881621003672 LexA repressor; Validated; Region: PRK00215 881621003673 Helix-turn-helix domains; Region: HTH; cl00088 881621003674 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 881621003675 Catalytic site [active] 881621003676 cell division suppressor protein YneA; Provisional; Region: PRK14125 881621003677 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 881621003678 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 881621003679 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 881621003680 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 881621003681 TPP-binding site [chemical binding]; other site 881621003682 dimer interface [polypeptide binding]; other site 881621003683 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 881621003684 PYR/PP interface [polypeptide binding]; other site 881621003685 dimer interface [polypeptide binding]; other site 881621003686 TPP binding site [chemical binding]; other site 881621003687 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 881621003688 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 881621003689 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 881621003690 weakly similar to arginine N-methyltransferases,C-terminal part 881621003691 weakly similar to arginine N-methyltransferases,N-terminal part 881621003692 ParB-like nuclease domain; Region: ParBc; cl02129 881621003693 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 881621003694 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 881621003695 Active Sites [active] 881621003696 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 881621003697 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 881621003698 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 881621003699 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 881621003700 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 881621003701 putative nucleotide binding site [chemical binding]; other site 881621003702 uridine monophosphate binding site [chemical binding]; other site 881621003703 homohexameric interface [polypeptide binding]; other site 881621003704 ribosome recycling factor; Reviewed; Region: frr; PRK00083 881621003705 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 881621003706 hinge region; other site 881621003707 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 881621003708 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 881621003709 catalytic residue [active] 881621003710 putative FPP diphosphate binding site; other site 881621003711 putative FPP binding hydrophobic cleft; other site 881621003712 dimer interface [polypeptide binding]; other site 881621003713 putative IPP diphosphate binding site; other site 881621003714 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 881621003715 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 881621003716 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 881621003717 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 881621003718 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 881621003719 prolyl-tRNA synthetase; Provisional; Region: PRK09194 881621003720 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 881621003721 dimer interface [polypeptide binding]; other site 881621003722 motif 1; other site 881621003723 active site 881621003724 motif 2; other site 881621003725 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 881621003726 putative deacylase active site [active] 881621003727 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 881621003728 active site 881621003729 motif 3; other site 881621003730 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 881621003731 anticodon binding site; other site 881621003732 DNA polymerase III PolC; Validated; Region: polC; PRK00448 881621003733 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 881621003734 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 881621003735 generic binding surface II; other site 881621003736 generic binding surface I; other site 881621003737 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 881621003738 active site 881621003739 substrate binding site [chemical binding]; other site 881621003740 catalytic site [active] 881621003741 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 881621003742 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 881621003743 NusA N-terminal domain; Region: NusA_N; pfam08529 881621003744 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 881621003745 RNA binding site [nucleotide binding]; other site 881621003746 homodimer interface [polypeptide binding]; other site 881621003747 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 881621003748 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 881621003749 G-X-X-G motif; other site 881621003750 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 881621003751 putative RNA binding cleft [nucleotide binding]; other site 881621003752 translation initiation factor IF-2; Validated; Region: infB; PRK05306 881621003753 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 881621003754 translation initiation factor IF-2; Region: IF-2; TIGR00487 881621003755 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 881621003756 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 881621003757 G1 box; other site 881621003758 putative GEF interaction site [polypeptide binding]; other site 881621003759 GTP/Mg2+ binding site [chemical binding]; other site 881621003760 Switch I region; other site 881621003761 G2 box; other site 881621003762 G3 box; other site 881621003763 Switch II region; other site 881621003764 G4 box; other site 881621003765 G5 box; other site 881621003766 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 881621003767 Translation-initiation factor 2; Region: IF-2; pfam11987 881621003768 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 881621003769 Ribosome-binding factor A; Region: RBFA; cl00542 881621003770 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 881621003771 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 881621003772 RNA binding site [nucleotide binding]; other site 881621003773 active site 881621003774 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 881621003775 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 881621003776 active site 881621003777 Riboflavin kinase; Region: Flavokinase; cl03312 881621003778 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 881621003779 16S/18S rRNA binding site [nucleotide binding]; other site 881621003780 S13e-L30e interaction site [polypeptide binding]; other site 881621003781 25S rRNA binding site [nucleotide binding]; other site 881621003782 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 881621003783 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 881621003784 RNase E interface [polypeptide binding]; other site 881621003785 trimer interface [polypeptide binding]; other site 881621003786 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 881621003787 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 881621003788 RNase E interface [polypeptide binding]; other site 881621003789 trimer interface [polypeptide binding]; other site 881621003790 active site 881621003791 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 881621003792 putative nucleic acid binding region [nucleotide binding]; other site 881621003793 G-X-X-G motif; other site 881621003794 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 881621003795 RNA binding site [nucleotide binding]; other site 881621003796 domain interface; other site 881621003797 GTPase RsgA; Reviewed; Region: PRK01889 881621003798 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 881621003799 RNA binding site [nucleotide binding]; other site 881621003800 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 881621003801 GTPase/Zn-binding domain interface [polypeptide binding]; other site 881621003802 GTP/Mg2+ binding site [chemical binding]; other site 881621003803 G4 box; other site 881621003804 G5 box; other site 881621003805 G1 box; other site 881621003806 Switch I region; other site 881621003807 G2 box; other site 881621003808 G3 box; other site 881621003809 Switch II region; other site 881621003810 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 881621003811 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 881621003812 Rhomboid family; Region: Rhomboid; cl11446 881621003813 TPR repeat; Region: TPR_11; pfam13414 881621003814 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 881621003815 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 881621003816 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 881621003817 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 881621003818 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 881621003819 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 881621003820 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 881621003821 Type II/IV secretion system protein; Region: T2SE; pfam00437 881621003822 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621003823 Walker A motif; other site 881621003824 ATP binding site [chemical binding]; other site 881621003825 Walker B motif; other site 881621003826 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 881621003827 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 881621003828 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 881621003829 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 881621003830 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 881621003831 tetramer interface [polypeptide binding]; other site 881621003832 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621003833 catalytic residue [active] 881621003834 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 881621003835 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 881621003836 tetramer interface [polypeptide binding]; other site 881621003837 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621003838 catalytic residue [active] 881621003839 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 881621003840 active site residue [active] 881621003841 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 881621003842 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 881621003843 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 881621003844 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 881621003845 active site 881621003846 elongation factor P; Validated; Region: PRK00529 881621003847 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 881621003848 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 881621003849 RNA binding site [nucleotide binding]; other site 881621003850 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 881621003851 RNA binding site [nucleotide binding]; other site 881621003852 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 881621003853 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 881621003854 carboxyltransferase (CT) interaction site; other site 881621003855 biotinylation site [posttranslational modification]; other site 881621003856 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 881621003857 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 881621003858 ATP-grasp domain; Region: ATP-grasp_4; cl03087 881621003859 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 881621003860 Asp23 family; Region: Asp23; cl00574 881621003861 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 881621003862 putative RNA binding site [nucleotide binding]; other site 881621003863 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14170 881621003864 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 881621003865 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 881621003866 homodimer interface [polypeptide binding]; other site 881621003867 NADP binding site [chemical binding]; other site 881621003868 substrate binding site [chemical binding]; other site 881621003869 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 881621003870 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 881621003871 generic binding surface II; other site 881621003872 generic binding surface I; other site 881621003873 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 881621003874 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 881621003875 substrate binding pocket [chemical binding]; other site 881621003876 chain length determination region; other site 881621003877 substrate-Mg2+ binding site; other site 881621003878 catalytic residues [active] 881621003879 aspartate-rich region 1; other site 881621003880 active site lid residues [active] 881621003881 aspartate-rich region 2; other site 881621003882 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 881621003883 DNA-binding site [nucleotide binding]; DNA binding site 881621003884 RNA-binding motif; other site 881621003885 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 881621003886 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 881621003887 TPP-binding site; other site 881621003888 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 881621003889 PYR/PP interface [polypeptide binding]; other site 881621003890 dimer interface [polypeptide binding]; other site 881621003891 TPP binding site [chemical binding]; other site 881621003892 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 881621003893 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 881621003894 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 881621003895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 881621003896 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 881621003897 arginine repressor; Provisional; Region: PRK04280 881621003898 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 881621003899 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 881621003900 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 881621003901 Walker A/P-loop; other site 881621003902 ATP binding site [chemical binding]; other site 881621003903 Q-loop/lid; other site 881621003904 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 881621003905 Q-loop/lid; other site 881621003906 ABC transporter signature motif; other site 881621003907 Walker B; other site 881621003908 D-loop; other site 881621003909 H-loop/switch region; other site 881621003910 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 881621003911 Acetokinase family; Region: Acetate_kinase; cl01029 881621003912 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 881621003913 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621003914 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 881621003915 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 881621003916 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 881621003917 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 881621003918 tetramer interface [polypeptide binding]; other site 881621003919 TPP-binding site [chemical binding]; other site 881621003920 heterodimer interface [polypeptide binding]; other site 881621003921 phosphorylation loop region [posttranslational modification] 881621003922 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 881621003923 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 881621003924 alpha subunit interface [polypeptide binding]; other site 881621003925 TPP binding site [chemical binding]; other site 881621003926 heterodimer interface [polypeptide binding]; other site 881621003927 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 881621003928 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 881621003929 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 881621003930 E3 interaction surface; other site 881621003931 lipoyl attachment site [posttranslational modification]; other site 881621003932 e3 binding domain; Region: E3_binding; pfam02817 881621003933 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 881621003934 peptidase T-like protein; Region: PepT-like; TIGR01883 881621003935 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 881621003936 metal binding site [ion binding]; metal-binding site 881621003937 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621003938 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 881621003939 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 881621003940 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 881621003941 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 881621003942 active site 881621003943 phosphorylation site [posttranslational modification] 881621003944 intermolecular recognition site; other site 881621003945 dimerization interface [polypeptide binding]; other site 881621003946 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 881621003947 DNA binding site [nucleotide binding] 881621003948 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 881621003949 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 881621003950 dimerization interface [polypeptide binding]; other site 881621003951 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 881621003952 dimer interface [polypeptide binding]; other site 881621003953 phosphorylation site [posttranslational modification] 881621003954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621003955 ATP binding site [chemical binding]; other site 881621003956 Mg2+ binding site [ion binding]; other site 881621003957 G-X-G motif; other site 881621003958 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 881621003959 Acylphosphatase; Region: Acylphosphatase; cl00551 881621003960 Protein of unknown function (DUF1033); Region: DUF1033; cl11549 881621003961 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 881621003962 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 881621003963 homotetramer interface [polypeptide binding]; other site 881621003964 FMN binding site [chemical binding]; other site 881621003965 homodimer contacts [polypeptide binding]; other site 881621003966 putative active site [active] 881621003967 putative substrate binding site [chemical binding]; other site 881621003968 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 881621003969 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 881621003970 active site residue [active] 881621003971 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 881621003972 Uncharacterized conserved protein [Function unknown]; Region: COG1284 881621003973 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 881621003974 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 881621003975 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 881621003976 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621003977 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 881621003978 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621003979 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 881621003980 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 881621003981 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 881621003982 ligand binding site [chemical binding]; other site 881621003983 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 881621003984 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621003985 Walker A/P-loop; other site 881621003986 ATP binding site [chemical binding]; other site 881621003987 Q-loop/lid; other site 881621003988 ABC transporter signature motif; other site 881621003989 Walker B; other site 881621003990 D-loop; other site 881621003991 H-loop/switch region; other site 881621003992 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 881621003993 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 881621003994 TM-ABC transporter signature motif; other site 881621003995 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 881621003996 TM-ABC transporter signature motif; other site 881621003997 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 881621003998 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 881621003999 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 881621004000 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 881621004001 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 881621004002 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 881621004003 classical (c) SDRs; Region: SDR_c; cd05233 881621004004 NAD(P) binding site [chemical binding]; other site 881621004005 active site 881621004006 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 881621004007 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 881621004008 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 881621004009 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 881621004010 competence damage-inducible protein A; Provisional; Region: PRK00549 881621004011 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 881621004012 putative MPT binding site; other site 881621004013 Competence-damaged protein; Region: CinA; cl00666 881621004014 recombinase A; Provisional; Region: recA; PRK09354 881621004015 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 881621004016 hexamer interface [polypeptide binding]; other site 881621004017 Walker A motif; other site 881621004018 ATP binding site [chemical binding]; other site 881621004019 Walker B motif; other site 881621004020 phosphodiesterase; Provisional; Region: PRK12704 881621004021 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 881621004022 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 881621004023 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621004024 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 881621004025 Coenzyme A binding pocket [chemical binding]; other site 881621004026 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 881621004027 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 881621004028 putative active site [active] 881621004029 metal binding site [ion binding]; metal-binding site 881621004030 homodimer binding site [polypeptide binding]; other site 881621004031 Protein of unknown function (DUF964); Region: DUF964; cl01483 881621004032 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 881621004033 MutS domain I; Region: MutS_I; pfam01624 881621004034 MutS domain II; Region: MutS_II; pfam05188 881621004035 MutS family domain IV; Region: MutS_IV; pfam05190 881621004036 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 881621004037 Walker A/P-loop; other site 881621004038 ATP binding site [chemical binding]; other site 881621004039 Q-loop/lid; other site 881621004040 ABC transporter signature motif; other site 881621004041 Walker B; other site 881621004042 D-loop; other site 881621004043 H-loop/switch region; other site 881621004044 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 881621004045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621004046 ATP binding site [chemical binding]; other site 881621004047 Mg2+ binding site [ion binding]; other site 881621004048 G-X-G motif; other site 881621004049 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 881621004050 ATP binding site [chemical binding]; other site 881621004051 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 881621004052 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 881621004053 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 881621004054 Pyruvate formate lyase 1; Region: PFL1; cd01678 881621004055 coenzyme A binding site [chemical binding]; other site 881621004056 active site 881621004057 catalytic residues [active] 881621004058 glycine loop; other site 881621004059 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 881621004060 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 881621004061 FeS/SAM binding site; other site 881621004062 Helix-turn-helix domains; Region: HTH; cl00088 881621004063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621004064 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621004065 putative substrate translocation pore; other site 881621004066 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 881621004067 similar to integrase/recombinase, C-terminal part 881621004068 similar to integrase/recombinase, N-terminal part 881621004069 Similar to transcriptional regulator, N-terminal part 881621004070 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 881621004071 partial, C-terminal part 881621004072 Putative peptidoglycan linked protein (LPXTG motif), c-terminal part 881621004073 Putative peptidoglycan linked protein (LPXTG motif), n-terminal part 881621004074 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 881621004075 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 881621004076 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 881621004077 putative acyltransferase; Provisional; Region: PRK05790 881621004078 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 881621004079 dimer interface [polypeptide binding]; other site 881621004080 active site 881621004081 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 881621004082 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 881621004083 dimer interface [polypeptide binding]; other site 881621004084 active site 881621004085 VanZ like family; Region: VanZ; cl01971 881621004086 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 881621004087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621004088 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 881621004089 Sulfatase; Region: Sulfatase; cl10460 881621004090 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 881621004091 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 881621004092 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 881621004093 FAD binding domain; Region: FAD_binding_4; pfam01565 881621004094 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 881621004095 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 881621004096 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 881621004097 Walker A/P-loop; other site 881621004098 ATP binding site [chemical binding]; other site 881621004099 Q-loop/lid; other site 881621004100 ABC transporter signature motif; other site 881621004101 Walker B; other site 881621004102 D-loop; other site 881621004103 H-loop/switch region; other site 881621004104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621004105 dimer interface [polypeptide binding]; other site 881621004106 conserved gate region; other site 881621004107 ABC-ATPase subunit interface; other site 881621004108 NMT1-like family; Region: NMT1_2; cl15260 881621004109 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 881621004110 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 881621004111 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 881621004112 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 881621004113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621004114 dimer interface [polypeptide binding]; other site 881621004115 conserved gate region; other site 881621004116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 881621004117 ABC-ATPase subunit interface; other site 881621004118 NMT1-like family; Region: NMT1_2; cl15260 881621004119 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 881621004120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621004121 dimer interface [polypeptide binding]; other site 881621004122 conserved gate region; other site 881621004123 putative PBP binding loops; other site 881621004124 ABC-ATPase subunit interface; other site 881621004125 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 881621004126 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 881621004127 Walker A/P-loop; other site 881621004128 ATP binding site [chemical binding]; other site 881621004129 Q-loop/lid; other site 881621004130 ABC transporter signature motif; other site 881621004131 Walker B; other site 881621004132 D-loop; other site 881621004133 H-loop/switch region; other site 881621004134 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 881621004135 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 881621004136 Protein of unknown function (DUF419); Region: DUF419; cl15265 881621004137 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 881621004138 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 881621004139 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 881621004140 ABC transporter; Region: ABC_tran_2; pfam12848 881621004141 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 881621004142 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 881621004143 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 881621004144 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 881621004145 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 881621004146 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 881621004147 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 881621004148 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 881621004149 dihydrodipicolinate synthase; Region: dapA; TIGR00674 881621004150 dimer interface [polypeptide binding]; other site 881621004151 active site 881621004152 catalytic residue [active] 881621004153 aspartate kinase I; Reviewed; Region: PRK08210 881621004154 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 881621004155 nucleotide binding site [chemical binding]; other site 881621004156 substrate binding site [chemical binding]; other site 881621004157 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 881621004158 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 881621004159 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 881621004160 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621004161 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 881621004162 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 881621004163 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 881621004164 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 881621004165 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 881621004166 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 881621004167 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 881621004168 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 881621004169 AzlC protein; Region: AzlC; cl00570 881621004170 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 881621004171 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 881621004172 PPIC-type PPIASE domain; Region: Rotamase; cl08278 881621004173 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 881621004174 metal binding site 2 [ion binding]; metal-binding site 881621004175 putative DNA binding helix; other site 881621004176 metal binding site 1 [ion binding]; metal-binding site 881621004177 dimer interface [polypeptide binding]; other site 881621004178 structural Zn2+ binding site [ion binding]; other site 881621004179 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 881621004180 ABC-ATPase subunit interface; other site 881621004181 dimer interface [polypeptide binding]; other site 881621004182 putative PBP binding regions; other site 881621004183 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 881621004184 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 881621004185 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 881621004186 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 881621004187 DHHA2 domain; Region: DHHA2; pfam02833 881621004188 endonuclease IV; Provisional; Region: PRK01060 881621004189 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 881621004190 AP (apurinic/apyrimidinic) site pocket; other site 881621004191 DNA interaction; other site 881621004192 Metal-binding active site; metal-binding site 881621004193 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 881621004194 DEAD-like helicases superfamily; Region: DEXDc; smart00487 881621004195 ATP binding site [chemical binding]; other site 881621004196 Mg++ binding site [ion binding]; other site 881621004197 motif III; other site 881621004198 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621004199 nucleotide binding region [chemical binding]; other site 881621004200 ATP-binding site [chemical binding]; other site 881621004201 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 881621004202 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 881621004203 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 881621004204 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621004205 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 881621004206 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 881621004207 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 881621004208 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 881621004209 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 881621004210 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 881621004211 DNA binding residues [nucleotide binding] 881621004212 DNA primase; Validated; Region: dnaG; PRK05667 881621004213 CHC2 zinc finger; Region: zf-CHC2; cl15369 881621004214 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 881621004215 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 881621004216 active site 881621004217 metal binding site [ion binding]; metal-binding site 881621004218 interdomain interaction site; other site 881621004219 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 881621004220 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 881621004221 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 881621004222 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 881621004223 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 881621004224 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 881621004225 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 881621004226 dimer interface [polypeptide binding]; other site 881621004227 motif 1; other site 881621004228 active site 881621004229 motif 2; other site 881621004230 motif 3; other site 881621004231 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 881621004232 Recombination protein O N terminal; Region: RecO_N; cl15812 881621004233 Recombination protein O C terminal; Region: RecO_C; pfam02565 881621004234 GTPase Era; Reviewed; Region: era; PRK00089 881621004235 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 881621004236 G1 box; other site 881621004237 GTP/Mg2+ binding site [chemical binding]; other site 881621004238 Switch I region; other site 881621004239 G2 box; other site 881621004240 Switch II region; other site 881621004241 G3 box; other site 881621004242 G4 box; other site 881621004243 G5 box; other site 881621004244 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 881621004245 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 881621004246 active site 881621004247 catalytic motif [active] 881621004248 Zn binding site [ion binding]; other site 881621004249 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 881621004250 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 881621004251 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 881621004252 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 881621004253 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 881621004254 Zn2+ binding site [ion binding]; other site 881621004255 Mg2+ binding site [ion binding]; other site 881621004256 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 881621004257 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621004258 GatB domain; Region: GatB_Yqey; cl11497 881621004259 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 881621004260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 881621004261 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 881621004262 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 881621004263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 881621004264 S-adenosylmethionine binding site [chemical binding]; other site 881621004265 chaperone protein DnaJ; Provisional; Region: PRK14280 881621004266 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 881621004267 HSP70 interaction site [polypeptide binding]; other site 881621004268 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 881621004269 substrate binding site [polypeptide binding]; other site 881621004270 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 881621004271 Zn binding sites [ion binding]; other site 881621004272 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 881621004273 dimer interface [polypeptide binding]; other site 881621004274 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 881621004275 heat shock protein GrpE; Provisional; Region: PRK14140 881621004276 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 881621004277 dimer interface [polypeptide binding]; other site 881621004278 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 881621004279 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 881621004280 HrcA protein C terminal domain; Region: HrcA; pfam01628 881621004281 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 881621004282 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 881621004283 FeS/SAM binding site; other site 881621004284 HemN C-terminal domain; Region: HemN_C; pfam06969 881621004285 similal to oxidoreductase, partial 881621004286 similal to oxidoreductase, partial 881621004287 GTP-binding protein LepA; Provisional; Region: PRK05433 881621004288 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 881621004289 G1 box; other site 881621004290 putative GEF interaction site [polypeptide binding]; other site 881621004291 GTP/Mg2+ binding site [chemical binding]; other site 881621004292 Switch I region; other site 881621004293 G2 box; other site 881621004294 G3 box; other site 881621004295 Switch II region; other site 881621004296 G4 box; other site 881621004297 G5 box; other site 881621004298 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 881621004299 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 881621004300 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 881621004301 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 881621004302 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 881621004303 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 881621004304 similar to putative integral membrane protein ComEC specifically required for DNA uptake but not for binding,C-terminal part 881621004305 similar to putative integral membrane protein ComEC specifically required for DNA uptake but not for binding,N-terminal part 881621004306 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 881621004307 catalytic motif [active] 881621004308 Zn binding site [ion binding]; other site 881621004309 SLBB domain; Region: SLBB; pfam10531 881621004310 comEA protein; Region: comE; TIGR01259 881621004311 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 881621004312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 881621004313 S-adenosylmethionine binding site [chemical binding]; other site 881621004314 Oligomerisation domain; Region: Oligomerisation; cl00519 881621004315 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 881621004316 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 881621004317 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 881621004318 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 881621004319 active site 881621004320 (T/H)XGH motif; other site 881621004321 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 881621004322 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 881621004323 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 881621004324 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 881621004325 shikimate binding site; other site 881621004326 NAD(P) binding site [chemical binding]; other site 881621004327 GTPase YqeH; Provisional; Region: PRK13796 881621004328 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 881621004329 GTP/Mg2+ binding site [chemical binding]; other site 881621004330 G4 box; other site 881621004331 G5 box; other site 881621004332 G1 box; other site 881621004333 Switch I region; other site 881621004334 G2 box; other site 881621004335 G3 box; other site 881621004336 Switch II region; other site 881621004337 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 881621004338 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621004339 motif II; other site 881621004340 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 881621004341 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 881621004342 active site 881621004343 Zn binding site [ion binding]; other site 881621004344 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 881621004345 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Provisional; Region: PRK07164 881621004346 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 881621004347 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 881621004348 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 881621004349 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 881621004350 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 881621004351 Sugar specificity; other site 881621004352 Pyrimidine base specificity; other site 881621004353 ATP-binding site [chemical binding]; other site 881621004354 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 881621004355 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 881621004356 S-adenosylmethionine binding site [chemical binding]; other site 881621004357 YceG-like family; Region: YceG; pfam02618 881621004358 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 881621004359 dimerization interface [polypeptide binding]; other site 881621004360 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 881621004361 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 881621004362 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 881621004363 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 881621004364 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 881621004365 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 881621004366 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 881621004367 motif 1; other site 881621004368 active site 881621004369 motif 2; other site 881621004370 motif 3; other site 881621004371 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 881621004372 DHHA1 domain; Region: DHHA1; pfam02272 881621004373 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621004374 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 881621004375 Walker A/P-loop; other site 881621004376 ATP binding site [chemical binding]; other site 881621004377 Q-loop/lid; other site 881621004378 ABC transporter signature motif; other site 881621004379 Walker B; other site 881621004380 D-loop; other site 881621004381 H-loop/switch region; other site 881621004382 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 881621004383 FtsX-like permease family; Region: FtsX; cl15850 881621004384 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 881621004385 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 881621004386 active site 881621004387 phosphorylation site [posttranslational modification] 881621004388 intermolecular recognition site; other site 881621004389 dimerization interface [polypeptide binding]; other site 881621004390 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 881621004391 DNA binding site [nucleotide binding] 881621004392 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 881621004393 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 881621004394 dimerization interface [polypeptide binding]; other site 881621004395 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 881621004396 dimer interface [polypeptide binding]; other site 881621004397 phosphorylation site [posttranslational modification] 881621004398 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621004399 ATP binding site [chemical binding]; other site 881621004400 Mg2+ binding site [ion binding]; other site 881621004401 G-X-G motif; other site 881621004402 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 881621004403 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621004404 Family description; Region: UvrD_C_2; cl15862 881621004405 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 881621004406 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 881621004407 TPR motif; other site 881621004408 binding surface 881621004409 TPR repeat; Region: TPR_11; pfam13414 881621004410 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 881621004411 binding surface 881621004412 TPR motif; other site 881621004413 TPR repeat; Region: TPR_11; pfam13414 881621004414 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 881621004415 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 881621004416 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 881621004417 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 881621004418 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 881621004419 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 881621004420 catalytic residue [active] 881621004421 recombination factor protein RarA; Reviewed; Region: PRK13342 881621004422 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621004423 Walker A motif; other site 881621004424 ATP binding site [chemical binding]; other site 881621004425 Walker B motif; other site 881621004426 arginine finger; other site 881621004427 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 881621004428 Predicted transcriptional regulator [Transcription]; Region: COG1959 881621004429 Helix-turn-helix domains; Region: HTH; cl00088 881621004430 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 881621004431 Nitrogen regulatory protein P-II; Region: P-II; cl00412 881621004432 Nitrogen regulatory protein P-II; Region: P-II; smart00938 881621004433 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 881621004434 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 881621004435 dimer interface [polypeptide binding]; other site 881621004436 anticodon binding site; other site 881621004437 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 881621004438 homodimer interface [polypeptide binding]; other site 881621004439 motif 1; other site 881621004440 active site 881621004441 motif 2; other site 881621004442 GAD domain; Region: GAD; pfam02938 881621004443 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 881621004444 motif 3; other site 881621004445 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 881621004446 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 881621004447 dimer interface [polypeptide binding]; other site 881621004448 motif 1; other site 881621004449 active site 881621004450 motif 2; other site 881621004451 motif 3; other site 881621004452 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 881621004453 anticodon binding site; other site 881621004454 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 881621004455 Bacterial SH3 domain; Region: SH3_3; cl02551 881621004456 Bacterial SH3 domain; Region: SH3_3; cl02551 881621004457 Bacterial SH3 domain; Region: SH3_3; cl02551 881621004458 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 881621004459 active site 881621004460 metal binding site [ion binding]; metal-binding site 881621004461 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 881621004462 putative active site [active] 881621004463 dimerization interface [polypeptide binding]; other site 881621004464 putative tRNAtyr binding site [nucleotide binding]; other site 881621004465 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 881621004466 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 881621004467 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 881621004468 synthetase active site [active] 881621004469 NTP binding site [chemical binding]; other site 881621004470 metal binding site [ion binding]; metal-binding site 881621004471 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 881621004472 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 881621004473 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 881621004474 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 881621004475 active site 881621004476 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 881621004477 DHH family; Region: DHH; pfam01368 881621004478 DHHA1 domain; Region: DHHA1; pfam02272 881621004479 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 881621004480 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 881621004481 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 881621004482 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 881621004483 Protein export membrane protein; Region: SecD_SecF; cl14618 881621004484 Protein export membrane protein; Region: SecD_SecF; cl14618 881621004485 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 881621004486 Preprotein translocase subunit; Region: YajC; cl00806 881621004487 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 881621004488 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 881621004489 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 881621004490 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 881621004491 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 881621004492 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621004493 Walker A motif; other site 881621004494 ATP binding site [chemical binding]; other site 881621004495 Walker B motif; other site 881621004496 arginine finger; other site 881621004497 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 881621004498 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 881621004499 RuvA N terminal domain; Region: RuvA_N; pfam01330 881621004500 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 881621004501 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 881621004502 tetramer (dimer of dimers) interface [polypeptide binding]; other site 881621004503 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 881621004504 NAD binding site [chemical binding]; other site 881621004505 dimer interface [polypeptide binding]; other site 881621004506 substrate binding site [chemical binding]; other site 881621004507 Transcriptional regulator; Region: Transcrip_reg; cl00361 881621004508 prephenate dehydratase; Provisional; Region: PRK11898 881621004509 Prephenate dehydratase; Region: PDT; pfam00800 881621004510 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 881621004511 putative L-Phe binding site [chemical binding]; other site 881621004512 GTPase CgtA; Reviewed; Region: obgE; PRK12297 881621004513 GTP1/OBG; Region: GTP1_OBG; pfam01018 881621004514 Obg GTPase; Region: Obg; cd01898 881621004515 G1 box; other site 881621004516 GTP/Mg2+ binding site [chemical binding]; other site 881621004517 Switch I region; other site 881621004518 G2 box; other site 881621004519 G3 box; other site 881621004520 Switch II region; other site 881621004521 G4 box; other site 881621004522 G5 box; other site 881621004523 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 881621004524 glycerol kinase; Provisional; Region: glpK; PRK00047 881621004525 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 881621004526 N- and C-terminal domain interface [polypeptide binding]; other site 881621004527 active site 881621004528 MgATP binding site [chemical binding]; other site 881621004529 catalytic site [active] 881621004530 metal binding site [ion binding]; metal-binding site 881621004531 glycerol binding site [chemical binding]; other site 881621004532 homotetramer interface [polypeptide binding]; other site 881621004533 homodimer interface [polypeptide binding]; other site 881621004534 FBP binding site [chemical binding]; other site 881621004535 protein IIAGlc interface [polypeptide binding]; other site 881621004536 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 881621004537 amphipathic channel; other site 881621004538 Asn-Pro-Ala signature motifs; other site 881621004539 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 881621004540 Protein of unknown function (DUF464); Region: DUF464; cl01080 881621004541 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 881621004542 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 881621004543 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 881621004544 homodimer interface [polypeptide binding]; other site 881621004545 oligonucleotide binding site [chemical binding]; other site 881621004546 septum site-determining protein MinD; Region: minD_bact; TIGR01968 881621004547 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 881621004548 Switch I; other site 881621004549 Switch II; other site 881621004550 septum formation inhibitor; Reviewed; Region: minC; PRK00513 881621004551 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 881621004552 rod shape-determining protein MreD; Region: MreD; cl01087 881621004553 rod shape-determining protein MreC; Provisional; Region: PRK13922 881621004554 rod shape-determining protein MreC; Region: MreC; pfam04085 881621004555 rod shape-determining protein MreB; Provisional; Region: PRK13927 881621004556 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 881621004557 ATP binding site [chemical binding]; other site 881621004558 profilin binding site; other site 881621004559 hypothetical protein; Reviewed; Region: PRK00024 881621004560 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 881621004561 MPN+ (JAMM) motif; other site 881621004562 Zinc-binding site [ion binding]; other site 881621004563 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 881621004564 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 881621004565 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 881621004566 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 881621004567 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 881621004568 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 881621004569 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 881621004570 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 881621004571 active site 881621004572 HIGH motif; other site 881621004573 nucleotide binding site [chemical binding]; other site 881621004574 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 881621004575 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 881621004576 active site 881621004577 KMSKS motif; other site 881621004578 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 881621004579 tRNA binding surface [nucleotide binding]; other site 881621004580 anticodon binding site; other site 881621004581 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 881621004582 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 881621004583 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 881621004584 inhibitor-cofactor binding pocket; inhibition site 881621004585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621004586 catalytic residue [active] 881621004587 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 881621004588 dimer interface [polypeptide binding]; other site 881621004589 active site 881621004590 Schiff base residues; other site 881621004591 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 881621004592 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 881621004593 active site 881621004594 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 881621004595 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 881621004596 domain interfaces; other site 881621004597 active site 881621004598 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 881621004599 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 881621004600 tRNA; other site 881621004601 putative tRNA binding site [nucleotide binding]; other site 881621004602 putative NADP binding site [chemical binding]; other site 881621004603 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 881621004604 Predicted GTPase [General function prediction only]; Region: COG0218 881621004605 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 881621004606 G1 box; other site 881621004607 GTP/Mg2+ binding site [chemical binding]; other site 881621004608 Switch I region; other site 881621004609 G2 box; other site 881621004610 G3 box; other site 881621004611 Switch II region; other site 881621004612 G4 box; other site 881621004613 G5 box; other site 881621004614 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 881621004615 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 881621004616 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 881621004617 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 881621004618 active site 881621004619 dimer interface [polypeptide binding]; other site 881621004620 motif 1; other site 881621004621 motif 2; other site 881621004622 motif 3; other site 881621004623 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 881621004624 anticodon binding site; other site 881621004625 primosomal protein DnaI; Reviewed; Region: PRK08939 881621004626 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 881621004627 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621004628 Walker A motif; other site 881621004629 ATP binding site [chemical binding]; other site 881621004630 Walker B motif; other site 881621004631 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 881621004632 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 881621004633 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 881621004634 ATP cone domain; Region: ATP-cone; pfam03477 881621004635 dephospho-CoA kinase; Region: TIGR00152 881621004636 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 881621004637 CoA-binding site [chemical binding]; other site 881621004638 ATP-binding [chemical binding]; other site 881621004639 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 881621004640 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 881621004641 DNA binding site [nucleotide binding] 881621004642 catalytic residue [active] 881621004643 H2TH interface [polypeptide binding]; other site 881621004644 putative catalytic residues [active] 881621004645 turnover-facilitating residue; other site 881621004646 intercalation triad [nucleotide binding]; other site 881621004647 8OG recognition residue [nucleotide binding]; other site 881621004648 putative reading head residues; other site 881621004649 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 881621004650 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 881621004651 DNA polymerase I; Provisional; Region: PRK05755 881621004652 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 881621004653 active site 881621004654 metal binding site 1 [ion binding]; metal-binding site 881621004655 putative 5' ssDNA interaction site; other site 881621004656 metal binding site 3; metal-binding site 881621004657 metal binding site 2 [ion binding]; metal-binding site 881621004658 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 881621004659 putative DNA binding site [nucleotide binding]; other site 881621004660 putative metal binding site [ion binding]; other site 881621004661 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 881621004662 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 881621004663 active site 881621004664 DNA binding site [nucleotide binding] 881621004665 catalytic site [active] 881621004666 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 881621004667 isocitrate dehydrogenase; Validated; Region: PRK07362 881621004668 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 881621004669 dimer interface [polypeptide binding]; other site 881621004670 Citrate synthase; Region: Citrate_synt; pfam00285 881621004671 active site 881621004672 citrylCoA binding site [chemical binding]; other site 881621004673 oxalacetate/citrate binding site [chemical binding]; other site 881621004674 coenzyme A binding site [chemical binding]; other site 881621004675 catalytic triad [active] 881621004676 Protein of unknown function (DUF441); Region: DUF441; cl01041 881621004677 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 881621004678 pyruvate kinase; Provisional; Region: PRK06354 881621004679 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 881621004680 domain interfaces; other site 881621004681 active site 881621004682 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 881621004683 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 881621004684 active site 881621004685 ADP/pyrophosphate binding site [chemical binding]; other site 881621004686 dimerization interface [polypeptide binding]; other site 881621004687 allosteric effector site; other site 881621004688 fructose-1,6-bisphosphate binding site; other site 881621004689 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 881621004690 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 881621004691 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 881621004692 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 881621004693 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 881621004694 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 881621004695 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 881621004696 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 881621004697 generic binding surface I; other site 881621004698 generic binding surface II; other site 881621004699 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 881621004700 DHH family; Region: DHH; pfam01368 881621004701 DHHA1 domain; Region: DHHA1; pfam02272 881621004702 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 881621004703 Helix-turn-helix domains; Region: HTH; cl00088 881621004704 DNA-binding site [nucleotide binding]; DNA binding site 881621004705 DRTGG domain; Region: DRTGG; cl12147 881621004706 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 881621004707 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 881621004708 active site 2 [active] 881621004709 active site 1 [active] 881621004710 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 881621004711 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 881621004712 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 881621004713 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 881621004714 active site 881621004715 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 881621004716 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 881621004717 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621004718 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 881621004719 Ligand Binding Site [chemical binding]; other site 881621004720 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621004721 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 881621004722 substrate binding pocket [chemical binding]; other site 881621004723 catalytic triad [active] 881621004724 Acetokinase family; Region: Acetate_kinase; cl01029 881621004725 propionate/acetate kinase; Provisional; Region: PRK12379 881621004726 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 881621004727 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 881621004728 dimer interface [polypeptide binding]; other site 881621004729 catalytic triad [active] 881621004730 peroxidatic and resolving cysteines [active] 881621004731 RDD family; Region: RDD; cl00746 881621004732 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 881621004733 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 881621004734 tandem repeat interface [polypeptide binding]; other site 881621004735 oligomer interface [polypeptide binding]; other site 881621004736 active site residues [active] 881621004737 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 881621004738 ornithine carbamoyltransferase; Provisional; Region: PRK00779 881621004739 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 881621004740 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621004741 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 881621004742 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 881621004743 inhibitor-cofactor binding pocket; inhibition site 881621004744 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621004745 catalytic residue [active] 881621004746 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 881621004747 nucleotide binding site [chemical binding]; other site 881621004748 N-acetyl-L-glutamate binding site [chemical binding]; other site 881621004749 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 881621004750 heterotetramer interface [polypeptide binding]; other site 881621004751 active site pocket [active] 881621004752 cleavage site 881621004753 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 881621004754 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621004755 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 881621004756 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 881621004757 THUMP domain; Region: THUMP; cl12076 881621004758 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 881621004759 Ligand Binding Site [chemical binding]; other site 881621004760 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 881621004761 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 881621004762 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 881621004763 catalytic residue [active] 881621004764 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 881621004765 GAF domain; Region: GAF; cl15785 881621004766 GAF domain; Region: GAF_2; pfam13185 881621004767 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 881621004768 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 881621004769 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 881621004770 RNA binding surface [nucleotide binding]; other site 881621004771 truncated, N-terminal part 881621004772 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 881621004773 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 881621004774 active site 881621004775 HIGH motif; other site 881621004776 dimer interface [polypeptide binding]; other site 881621004777 KMSKS motif; other site 881621004778 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 881621004779 RNA binding surface [nucleotide binding]; other site 881621004780 catabolite control protein A; Region: ccpA; TIGR01481 881621004781 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621004782 DNA binding site [nucleotide binding] 881621004783 domain linker motif; other site 881621004784 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 881621004785 dimerization interface [polypeptide binding]; other site 881621004786 effector binding site; other site 881621004787 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 881621004788 Chorismate mutase type II; Region: CM_2; cl00693 881621004789 NeuB family; Region: NeuB; cl00496 881621004790 YtxH-like protein; Region: YtxH; cl02079 881621004791 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 881621004792 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 881621004793 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 881621004794 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 881621004795 dimer interface [polypeptide binding]; other site 881621004796 decamer (pentamer of dimers) interface [polypeptide binding]; other site 881621004797 catalytic triad [active] 881621004798 peroxidatic and resolving cysteines [active] 881621004799 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 881621004800 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 881621004801 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 881621004802 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 881621004803 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 881621004804 dsRNA-gated channel SID-1; Region: SID-1_RNA_chan; pfam13965 881621004805 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621004806 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 881621004807 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 881621004808 putative tRNA-binding site [nucleotide binding]; other site 881621004809 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 881621004810 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 881621004811 catalytic residues [active] 881621004812 Protein of unknown function (DUF1673); Region: DUF1673; pfam07895 881621004813 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 881621004814 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 881621004815 oligomer interface [polypeptide binding]; other site 881621004816 active site 881621004817 metal binding site [ion binding]; metal-binding site 881621004818 Predicted small secreted protein [Function unknown]; Region: COG5584 881621004819 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 881621004820 methionine cluster; other site 881621004821 active site 881621004822 phosphorylation site [posttranslational modification] 881621004823 metal binding site [ion binding]; metal-binding site 881621004824 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 881621004825 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 881621004826 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 881621004827 Fibronectin type III-like domain; Region: Fn3-like; cl15273 881621004828 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 881621004829 active site 881621004830 P-loop; other site 881621004831 phosphorylation site [posttranslational modification] 881621004832 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 881621004833 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 881621004834 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 881621004835 Helix-turn-helix domains; Region: HTH; cl00088 881621004836 Helix-turn-helix domains; Region: HTH; cl00088 881621004837 PRD domain; Region: PRD; cl15445 881621004838 PRD domain; Region: PRD; cl15445 881621004839 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 881621004840 P-loop; other site 881621004841 active site 881621004842 phosphorylation site [posttranslational modification] 881621004843 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621004844 active site 881621004845 phosphorylation site [posttranslational modification] 881621004846 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 881621004847 putative homotetramer interface [polypeptide binding]; other site 881621004848 putative homodimer interface [polypeptide binding]; other site 881621004849 putative allosteric switch controlling residues; other site 881621004850 putative metal binding site [ion binding]; other site 881621004851 putative homodimer-homodimer interface [polypeptide binding]; other site 881621004852 similar to unknown protein, C-terminal part 881621004853 similar to unknown protein, N-terminal part 881621004854 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 881621004855 Phosphotransferase enzyme family; Region: APH; pfam01636 881621004856 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 881621004857 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 881621004858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621004859 putative substrate translocation pore; other site 881621004860 Transcriptional regulators [Transcription]; Region: MarR; COG1846 881621004861 Helix-turn-helix domains; Region: HTH; cl00088 881621004862 Helix-turn-helix domains; Region: HTH; cl00088 881621004863 Transposase, Mutator family; Region: Transposase_mut; pfam00872 881621004864 MULE transposase domain; Region: MULE; pfam10551 881621004865 similar to unknown protein 881621004866 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 881621004867 homodimer interface [polypeptide binding]; other site 881621004868 substrate-cofactor binding pocket; other site 881621004869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621004870 catalytic residue [active] 881621004871 dipeptidase PepV; Reviewed; Region: PRK07318 881621004872 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 881621004873 active site 881621004874 metal binding site [ion binding]; metal-binding site 881621004875 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699 881621004876 nudix motif; other site 881621004877 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 881621004878 putative substrate binding site [chemical binding]; other site 881621004879 putative ATP binding site [chemical binding]; other site 881621004880 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 881621004881 active site 881621004882 stage V sporulation protein B; Region: spore_V_B; TIGR02900 881621004883 MatE; Region: MatE; cl10513 881621004884 MatE; Region: MatE; cl10513 881621004885 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 881621004886 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 881621004887 substrate binding site [chemical binding]; other site 881621004888 active site 881621004889 catalytic residues [active] 881621004890 heterodimer interface [polypeptide binding]; other site 881621004891 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 881621004892 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 881621004893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621004894 catalytic residue [active] 881621004895 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 881621004896 active site 881621004897 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 881621004898 active site 881621004899 ribulose/triose binding site [chemical binding]; other site 881621004900 phosphate binding site [ion binding]; other site 881621004901 substrate (anthranilate) binding pocket [chemical binding]; other site 881621004902 product (indole) binding pocket [chemical binding]; other site 881621004903 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 881621004904 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 881621004905 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 881621004906 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 881621004907 Glutamine amidotransferase class-I; Region: GATase; pfam00117 881621004908 glutamine binding [chemical binding]; other site 881621004909 catalytic triad [active] 881621004910 anthranilate synthase component I; Provisional; Region: PRK13570 881621004911 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 881621004912 chorismate binding enzyme; Region: Chorismate_bind; cl10555 881621004913 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 881621004914 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 881621004915 putative catalytic cysteine [active] 881621004916 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 881621004917 putative active site [active] 881621004918 metal binding site [ion binding]; metal-binding site 881621004919 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 881621004920 dimer interface [polypeptide binding]; other site 881621004921 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 881621004922 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621004923 Walker A/P-loop; other site 881621004924 ATP binding site [chemical binding]; other site 881621004925 Q-loop/lid; other site 881621004926 ABC transporter signature motif; other site 881621004927 Walker B; other site 881621004928 D-loop; other site 881621004929 H-loop/switch region; other site 881621004930 ABC-2 type transporter; Region: ABC2_membrane; cl11417 881621004931 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 881621004932 putative dimer interface [polypeptide binding]; other site 881621004933 catalytic triad [active] 881621004934 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 881621004935 aconitate hydratase; Validated; Region: PRK09277 881621004936 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 881621004937 substrate binding site [chemical binding]; other site 881621004938 ligand binding site [chemical binding]; other site 881621004939 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 881621004940 substrate binding site [chemical binding]; other site 881621004941 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 881621004942 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 881621004943 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 881621004944 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 881621004945 ATP binding site [chemical binding]; other site 881621004946 putative Mg++ binding site [ion binding]; other site 881621004947 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621004948 nucleotide binding region [chemical binding]; other site 881621004949 ATP-binding site [chemical binding]; other site 881621004950 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 881621004951 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 881621004952 Walker A/P-loop; other site 881621004953 ATP binding site [chemical binding]; other site 881621004954 Q-loop/lid; other site 881621004955 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 881621004956 ABC transporter signature motif; other site 881621004957 Walker B; other site 881621004958 D-loop; other site 881621004959 H-loop/switch region; other site 881621004960 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 881621004961 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 881621004962 active site 881621004963 metal binding site [ion binding]; metal-binding site 881621004964 DNA binding site [nucleotide binding] 881621004965 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 881621004966 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 881621004967 putative acyl-acceptor binding pocket; other site 881621004968 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 881621004969 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 881621004970 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 881621004971 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 881621004972 Walker A/P-loop; other site 881621004973 ATP binding site [chemical binding]; other site 881621004974 Q-loop/lid; other site 881621004975 ABC transporter signature motif; other site 881621004976 Walker B; other site 881621004977 D-loop; other site 881621004978 H-loop/switch region; other site 881621004979 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 881621004980 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 881621004981 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621004982 Walker A/P-loop; other site 881621004983 ATP binding site [chemical binding]; other site 881621004984 Q-loop/lid; other site 881621004985 ABC transporter signature motif; other site 881621004986 Walker B; other site 881621004987 D-loop; other site 881621004988 H-loop/switch region; other site 881621004989 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 881621004990 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 881621004991 active site 881621004992 active site 881621004993 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 881621004994 active site 881621004995 similar to peptidoglycan hydrolase (phage related),C-terminal part unknown 881621004996 similar to peptidoglycan hydrolase (phage related),internal part 881621004997 similar to peptidoglycan hydrolase (phage related),N-terminal part 881621004998 Bacteriophage holin; Region: Phage_holin_1; cl02344 881621004999 elongation factor Ts; Provisional; Region: tsf; PRK09377 881621005000 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 881621005001 Elongation factor TS; Region: EF_TS; pfam00889 881621005002 Elongation factor TS; Region: EF_TS; pfam00889 881621005003 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 881621005004 rRNA interaction site [nucleotide binding]; other site 881621005005 S8 interaction site; other site 881621005006 putative laminin-1 binding site; other site 881621005007 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 881621005008 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 881621005009 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 881621005010 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 881621005011 active site 881621005012 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 881621005013 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 881621005014 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 881621005015 putative active site [active] 881621005016 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 881621005017 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 881621005018 putative active site [active] 881621005019 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 881621005020 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 881621005021 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 881621005022 putative acetyltransferase; Provisional; Region: PRK03624 881621005023 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621005024 Coenzyme A binding pocket [chemical binding]; other site 881621005025 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 881621005026 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 881621005027 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 881621005028 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 881621005029 HIGH motif; other site 881621005030 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 881621005031 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 881621005032 active site 881621005033 KMSKS motif; other site 881621005034 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 881621005035 tRNA binding surface [nucleotide binding]; other site 881621005036 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 881621005037 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 881621005038 FeS/SAM binding site; other site 881621005039 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621005040 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621005041 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 881621005042 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 881621005043 active site 881621005044 dimer interface [polypeptide binding]; other site 881621005045 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 881621005046 Ligand Binding Site [chemical binding]; other site 881621005047 Molecular Tunnel; other site 881621005048 S-adenosylmethionine synthetase; Validated; Region: PRK05250 881621005049 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 881621005050 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 881621005051 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 881621005052 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 881621005053 tetramer (dimer of dimers) interface [polypeptide binding]; other site 881621005054 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 881621005055 NAD binding site [chemical binding]; other site 881621005056 dimer interface [polypeptide binding]; other site 881621005057 substrate binding site [chemical binding]; other site 881621005058 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 881621005059 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 881621005060 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 881621005061 nudix motif; other site 881621005062 Haemolytic domain; Region: Haemolytic; cl00506 881621005063 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 881621005064 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 881621005065 metal binding site [ion binding]; metal-binding site 881621005066 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 881621005067 AMP-binding enzyme; Region: AMP-binding; cl15778 881621005068 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 881621005069 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 881621005070 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 881621005071 substrate binding site [chemical binding]; other site 881621005072 oxyanion hole (OAH) forming residues; other site 881621005073 trimer interface [polypeptide binding]; other site 881621005074 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621005075 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 881621005076 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621005077 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 881621005078 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 881621005079 dimer interface [polypeptide binding]; other site 881621005080 tetramer interface [polypeptide binding]; other site 881621005081 PYR/PP interface [polypeptide binding]; other site 881621005082 TPP binding site [chemical binding]; other site 881621005083 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 881621005084 TPP-binding site; other site 881621005085 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 881621005086 chorismate binding enzyme; Region: Chorismate_bind; cl10555 881621005087 UbiA prenyltransferase family; Region: UbiA; cl00337 881621005088 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 881621005089 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 881621005090 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 881621005091 FAD binding site [chemical binding]; other site 881621005092 cystathionine beta-lyase; Provisional; Region: PRK08064 881621005093 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 881621005094 homodimer interface [polypeptide binding]; other site 881621005095 substrate-cofactor binding pocket; other site 881621005096 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621005097 catalytic residue [active] 881621005098 cystathionine gamma-synthase; Reviewed; Region: PRK08247 881621005099 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 881621005100 homodimer interface [polypeptide binding]; other site 881621005101 substrate-cofactor binding pocket; other site 881621005102 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621005103 catalytic residue [active] 881621005104 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 881621005105 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 881621005106 THF binding site; other site 881621005107 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 881621005108 substrate binding site [chemical binding]; other site 881621005109 THF binding site; other site 881621005110 zinc-binding site [ion binding]; other site 881621005111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621005112 putative substrate translocation pore; other site 881621005113 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 881621005114 metal binding site 2 [ion binding]; metal-binding site 881621005115 putative DNA binding helix; other site 881621005116 metal binding site 1 [ion binding]; metal-binding site 881621005117 dimer interface [polypeptide binding]; other site 881621005118 structural Zn2+ binding site [ion binding]; other site 881621005119 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 881621005120 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621005121 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 881621005122 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 881621005123 inhibitor-cofactor binding pocket; inhibition site 881621005124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621005125 catalytic residue [active] 881621005126 Predicted membrane protein [Function unknown]; Region: COG4129 881621005127 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 881621005128 Protein of unknown function (DUF402); Region: DUF402; cl00979 881621005129 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 881621005130 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 881621005131 putative NAD(P) binding site [chemical binding]; other site 881621005132 active site 881621005133 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 881621005134 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 881621005135 minor groove reading motif; other site 881621005136 helix-hairpin-helix signature motif; other site 881621005137 substrate binding pocket [chemical binding]; other site 881621005138 active site 881621005139 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 881621005140 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 881621005141 DNA binding and oxoG recognition site [nucleotide binding] 881621005142 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 881621005143 Transposase domain (DUF772); Region: DUF772; cl15789 881621005144 Transposase domain (DUF772); Region: DUF772; cl15789 881621005145 Transposase domain (DUF772); Region: DUF772; cl15789 881621005146 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 881621005147 trimer interface [polypeptide binding]; other site 881621005148 active site 881621005149 WVELL protein; Region: WVELL; pfam14043 881621005150 RecX family; Region: RecX; cl00936 881621005151 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621005152 TIGR01777 family protein; Region: yfcH 881621005153 NAD(P) binding site [chemical binding]; other site 881621005154 active site 881621005155 Predicted integral membrane protein [Function unknown]; Region: COG0392 881621005156 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 881621005157 Uncharacterized conserved protein [Function unknown]; Region: COG2898 881621005158 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 881621005159 VanZ like family; Region: VanZ; cl01971 881621005160 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 881621005161 Cation efflux family; Region: Cation_efflux; cl00316 881621005162 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 881621005163 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 881621005164 PAS fold; Region: PAS_4; pfam08448 881621005165 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 881621005166 putative active site [active] 881621005167 heme pocket [chemical binding]; other site 881621005168 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 881621005169 dimer interface [polypeptide binding]; other site 881621005170 putative CheW interface [polypeptide binding]; other site 881621005171 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 881621005172 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 881621005173 active site 881621005174 metal binding site [ion binding]; metal-binding site 881621005175 TRAM domain; Region: TRAM; cl01282 881621005176 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 881621005177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 881621005178 S-adenosylmethionine binding site [chemical binding]; other site 881621005179 OsmC-like protein; Region: OsmC; cl00767 881621005180 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 881621005181 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 881621005182 Substrate-binding site [chemical binding]; other site 881621005183 Substrate specificity [chemical binding]; other site 881621005184 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 881621005185 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 881621005186 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 881621005187 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 881621005188 active site 881621005189 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 881621005190 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 881621005191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621005192 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621005193 putative substrate translocation pore; other site 881621005194 rod-share determining protein MreBH; Provisional; Region: PRK13929 881621005195 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 881621005196 ATP binding site [chemical binding]; other site 881621005197 Cell division protein FtsA; Region: FtsA; cl11496 881621005198 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621005199 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 881621005200 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621005201 Substrate binding site [chemical binding]; other site 881621005202 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621005203 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621005204 LRR adjacent; Region: LRR_adjacent; pfam08191 881621005205 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621005206 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621005207 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621005208 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621005209 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 881621005210 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621005211 Leucine rich repeat; Region: LRR_8; pfam13855 881621005212 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621005213 LRR adjacent; Region: LRR_adjacent; pfam08191 881621005214 Uncharacterized conserved protein [Function unknown]; Region: COG4748 881621005215 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 881621005216 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 881621005217 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 881621005218 methionine cluster; other site 881621005219 active site 881621005220 phosphorylation site [posttranslational modification] 881621005221 metal binding site [ion binding]; metal-binding site 881621005222 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 881621005223 active site 881621005224 P-loop; other site 881621005225 phosphorylation site [posttranslational modification] 881621005226 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 881621005227 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621005228 Walker A motif; other site 881621005229 ATP binding site [chemical binding]; other site 881621005230 Walker B motif; other site 881621005231 arginine finger; other site 881621005232 Transcriptional antiterminator [Transcription]; Region: COG3933 881621005233 PRD domain; Region: PRD; cl15445 881621005234 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 881621005235 active pocket/dimerization site; other site 881621005236 active site 881621005237 phosphorylation site [posttranslational modification] 881621005238 PRD domain; Region: PRD; cl15445 881621005239 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621005240 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 881621005241 ATP binding site [chemical binding]; other site 881621005242 putative Mg++ binding site [ion binding]; other site 881621005243 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621005244 nucleotide binding region [chemical binding]; other site 881621005245 ATP-binding site [chemical binding]; other site 881621005246 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 881621005247 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 881621005248 Walker A/P-loop; other site 881621005249 ATP binding site [chemical binding]; other site 881621005250 Q-loop/lid; other site 881621005251 ABC transporter signature motif; other site 881621005252 Walker B; other site 881621005253 D-loop; other site 881621005254 H-loop/switch region; other site 881621005255 Predicted transcriptional regulators [Transcription]; Region: COG1725 881621005256 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621005257 DNA-binding site [nucleotide binding]; DNA binding site 881621005258 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 881621005259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621005260 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621005261 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621005262 DNA binding site [nucleotide binding] 881621005263 domain linker motif; other site 881621005264 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 881621005265 dimerization interface [polypeptide binding]; other site 881621005266 ligand binding site [chemical binding]; other site 881621005267 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 881621005268 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 881621005269 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 881621005270 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 881621005271 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 881621005272 Fibronectin type III-like domain; Region: Fn3-like; cl15273 881621005273 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 881621005274 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 881621005275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621005276 dimer interface [polypeptide binding]; other site 881621005277 conserved gate region; other site 881621005278 putative PBP binding loops; other site 881621005279 ABC-ATPase subunit interface; other site 881621005280 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 881621005281 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621005282 dimer interface [polypeptide binding]; other site 881621005283 conserved gate region; other site 881621005284 putative PBP binding loops; other site 881621005285 ABC-ATPase subunit interface; other site 881621005286 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 881621005287 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621005288 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621005289 NAD(P) binding pocket [chemical binding]; other site 881621005290 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 881621005291 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 881621005292 active site 881621005293 dimer interface [polypeptide binding]; other site 881621005294 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 881621005295 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 881621005296 active site 881621005297 FMN binding site [chemical binding]; other site 881621005298 substrate binding site [chemical binding]; other site 881621005299 3Fe-4S cluster binding site [ion binding]; other site 881621005300 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 881621005301 domain interface; other site 881621005302 Transcriptional regulator [Transcription]; Region: LysR; COG0583 881621005303 Helix-turn-helix domains; Region: HTH; cl00088 881621005304 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 881621005305 putative dimerization interface [polypeptide binding]; other site 881621005306 Predicted acetyltransferase [General function prediction only]; Region: COG3153 881621005307 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621005308 Coenzyme A binding pocket [chemical binding]; other site 881621005309 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 881621005310 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 881621005311 putative active site [active] 881621005312 metal binding site [ion binding]; metal-binding site 881621005313 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 881621005314 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 881621005315 substrate binding pocket [chemical binding]; other site 881621005316 membrane-bound complex binding site; other site 881621005317 hinge residues; other site 881621005318 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621005319 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621005320 Walker A/P-loop; other site 881621005321 ATP binding site [chemical binding]; other site 881621005322 Q-loop/lid; other site 881621005323 ABC transporter signature motif; other site 881621005324 Walker B; other site 881621005325 D-loop; other site 881621005326 H-loop/switch region; other site 881621005327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621005328 dimer interface [polypeptide binding]; other site 881621005329 conserved gate region; other site 881621005330 putative PBP binding loops; other site 881621005331 ABC-ATPase subunit interface; other site 881621005332 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 881621005333 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621005334 ATP binding site [chemical binding]; other site 881621005335 Mg2+ binding site [ion binding]; other site 881621005336 G-X-G motif; other site 881621005337 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 881621005338 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 881621005339 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 881621005340 active site 881621005341 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 881621005342 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 881621005343 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 881621005344 putative NAD(P) binding site [chemical binding]; other site 881621005345 active site 881621005346 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 881621005347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 881621005348 active site 881621005349 phosphorylation site [posttranslational modification] 881621005350 intermolecular recognition site; other site 881621005351 dimerization interface [polypeptide binding]; other site 881621005352 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 881621005353 DNA binding site [nucleotide binding] 881621005354 FtsX-like permease family; Region: FtsX; cl15850 881621005355 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621005356 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 881621005357 Walker A/P-loop; other site 881621005358 ATP binding site [chemical binding]; other site 881621005359 Q-loop/lid; other site 881621005360 ABC transporter signature motif; other site 881621005361 Walker B; other site 881621005362 D-loop; other site 881621005363 H-loop/switch region; other site 881621005364 Predicted amidohydrolase [General function prediction only]; Region: COG0388 881621005365 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 881621005366 active site 881621005367 catalytic triad [active] 881621005368 dimer interface [polypeptide binding]; other site 881621005369 Shikimate kinase; Region: SKI; pfam01202 881621005370 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 881621005371 ADP binding site [chemical binding]; other site 881621005372 magnesium binding site [ion binding]; other site 881621005373 putative shikimate binding site; other site 881621005374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 881621005375 TRAM domain; Region: TRAM; cl01282 881621005376 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 881621005377 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 881621005378 putative lipid kinase; Reviewed; Region: PRK13337 881621005379 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 881621005380 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 881621005381 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 881621005382 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 881621005383 GatB domain; Region: GatB_Yqey; cl11497 881621005384 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 881621005385 Amidase; Region: Amidase; cl11426 881621005386 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 881621005387 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 881621005388 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 881621005389 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 881621005390 nucleotide binding pocket [chemical binding]; other site 881621005391 K-X-D-G motif; other site 881621005392 catalytic site [active] 881621005393 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 881621005394 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 881621005395 Dimer interface [polypeptide binding]; other site 881621005396 BRCT sequence motif; other site 881621005397 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 881621005398 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621005399 Family description; Region: UvrD_C_2; cl15862 881621005400 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 881621005401 substrate binding site [chemical binding]; other site 881621005402 putative active site [active] 881621005403 dimer interface [polypeptide binding]; other site 881621005404 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 881621005405 Helix-turn-helix domains; Region: HTH; cl00088 881621005406 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 881621005407 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 881621005408 ATP-grasp domain; Region: ATP-grasp_4; cl03087 881621005409 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 881621005410 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 881621005411 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 881621005412 purine monophosphate binding site [chemical binding]; other site 881621005413 dimer interface [polypeptide binding]; other site 881621005414 putative catalytic residues [active] 881621005415 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 881621005416 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 881621005417 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 881621005418 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 881621005419 active site 881621005420 substrate binding site [chemical binding]; other site 881621005421 cosubstrate binding site; other site 881621005422 catalytic site [active] 881621005423 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 881621005424 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 881621005425 dimerization interface [polypeptide binding]; other site 881621005426 putative ATP binding site [chemical binding]; other site 881621005427 amidophosphoribosyltransferase; Provisional; Region: PRK06781 881621005428 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 881621005429 active site 881621005430 tetramer interface [polypeptide binding]; other site 881621005431 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 881621005432 active site 881621005433 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 881621005434 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 881621005435 dimerization interface [polypeptide binding]; other site 881621005436 ATP binding site [chemical binding]; other site 881621005437 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 881621005438 dimerization interface [polypeptide binding]; other site 881621005439 ATP binding site [chemical binding]; other site 881621005440 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 881621005441 putative active site [active] 881621005442 catalytic triad [active] 881621005443 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 881621005444 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 881621005445 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 881621005446 ATP binding site [chemical binding]; other site 881621005447 active site 881621005448 substrate binding site [chemical binding]; other site 881621005449 adenylosuccinate lyase; Provisional; Region: PRK07492 881621005450 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 881621005451 tetramer interface [polypeptide binding]; other site 881621005452 active site 881621005453 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621005454 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 881621005455 ATP-grasp domain; Region: ATP-grasp_4; cl03087 881621005456 AIR carboxylase; Region: AIRC; cl00310 881621005457 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 881621005458 hypothetical protein; Provisional; Region: PRK04164 881621005459 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 881621005460 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 881621005461 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 881621005462 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621005463 Walker A/P-loop; other site 881621005464 ATP binding site [chemical binding]; other site 881621005465 Q-loop/lid; other site 881621005466 ABC transporter signature motif; other site 881621005467 Walker B; other site 881621005468 D-loop; other site 881621005469 H-loop/switch region; other site 881621005470 peptidase T; Region: peptidase-T; TIGR01882 881621005471 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 881621005472 metal binding site [ion binding]; metal-binding site 881621005473 dimer interface [polypeptide binding]; other site 881621005474 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 881621005475 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 881621005476 active site 881621005477 DNA binding site [nucleotide binding] 881621005478 putative phosphate binding site [ion binding]; other site 881621005479 putative catalytic site [active] 881621005480 metal binding site A [ion binding]; metal-binding site 881621005481 AP binding site [nucleotide binding]; other site 881621005482 metal binding site B [ion binding]; metal-binding site 881621005483 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 881621005484 23S rRNA binding site [nucleotide binding]; other site 881621005485 L21 binding site [polypeptide binding]; other site 881621005486 L13 binding site [polypeptide binding]; other site 881621005487 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 881621005488 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 881621005489 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 881621005490 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 881621005491 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 881621005492 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 881621005493 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 881621005494 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 881621005495 RimM N-terminal domain; Region: RimM; pfam01782 881621005496 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 881621005497 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 881621005498 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 881621005499 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 881621005500 catalytic triad [active] 881621005501 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 881621005502 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 881621005503 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 881621005504 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 881621005505 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 881621005506 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 881621005507 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 881621005508 signal recognition particle protein; Provisional; Region: PRK10867 881621005509 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 881621005510 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 881621005511 P loop; other site 881621005512 GTP binding site [chemical binding]; other site 881621005513 Signal peptide binding domain; Region: SRP_SPB; pfam02978 881621005514 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 881621005515 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 881621005516 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 881621005517 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 881621005518 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 881621005519 P loop; other site 881621005520 GTP binding site [chemical binding]; other site 881621005521 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 881621005522 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 881621005523 Walker A/P-loop; other site 881621005524 ATP binding site [chemical binding]; other site 881621005525 Q-loop/lid; other site 881621005526 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 881621005527 Protein of unknown function (DUF773); Region: DUF773; pfam05600 881621005528 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 881621005529 ABC transporter signature motif; other site 881621005530 Walker B; other site 881621005531 D-loop; other site 881621005532 H-loop/switch region; other site 881621005533 ribonuclease III; Reviewed; Region: rnc; PRK00102 881621005534 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 881621005535 dimerization interface [polypeptide binding]; other site 881621005536 active site 881621005537 metal binding site [ion binding]; metal-binding site 881621005538 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 881621005539 dsRNA binding site [nucleotide binding]; other site 881621005540 Phosphopantetheine attachment site; Region: PP-binding; cl09936 881621005541 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 881621005542 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 881621005543 NAD(P) binding site [chemical binding]; other site 881621005544 homotetramer interface [polypeptide binding]; other site 881621005545 homodimer interface [polypeptide binding]; other site 881621005546 active site 881621005547 Acyl transferase domain; Region: Acyl_transf_1; cl08282 881621005548 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 881621005549 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 881621005550 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 881621005551 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 881621005552 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 881621005553 Y-family of DNA polymerases; Region: PolY; cl12025 881621005554 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 881621005555 generic binding surface II; other site 881621005556 ssDNA binding site; other site 881621005557 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 881621005558 ATP binding site [chemical binding]; other site 881621005559 putative Mg++ binding site [ion binding]; other site 881621005560 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621005561 nucleotide binding region [chemical binding]; other site 881621005562 ATP-binding site [chemical binding]; other site 881621005563 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 881621005564 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 881621005565 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 881621005566 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 881621005567 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 881621005568 putative L-serine binding site [chemical binding]; other site 881621005569 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 881621005570 DAK2 domain; Region: Dak2; cl03685 881621005571 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 881621005572 Asp23 family; Region: Asp23; cl00574 881621005573 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 881621005574 Thiamine pyrophosphokinase; Region: TPK; cd07995 881621005575 active site 881621005576 dimerization interface [polypeptide binding]; other site 881621005577 thiamine binding site [chemical binding]; other site 881621005578 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 881621005579 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 881621005580 substrate binding site [chemical binding]; other site 881621005581 hexamer interface [polypeptide binding]; other site 881621005582 metal binding site [ion binding]; metal-binding site 881621005583 GTPase RsgA; Reviewed; Region: PRK00098 881621005584 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 881621005585 RNA binding site [nucleotide binding]; other site 881621005586 homodimer interface [polypeptide binding]; other site 881621005587 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 881621005588 GTPase/Zn-binding domain interface [polypeptide binding]; other site 881621005589 GTP/Mg2+ binding site [chemical binding]; other site 881621005590 G4 box; other site 881621005591 G1 box; other site 881621005592 Switch I region; other site 881621005593 G2 box; other site 881621005594 G3 box; other site 881621005595 Switch II region; other site 881621005596 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 881621005597 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 881621005598 active site 881621005599 ATP binding site [chemical binding]; other site 881621005600 substrate binding site [chemical binding]; other site 881621005601 activation loop (A-loop); other site 881621005602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 881621005603 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 881621005604 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 881621005605 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 881621005606 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 881621005607 Protein phosphatase 2C; Region: PP2C; pfam00481 881621005608 active site 881621005609 16S rRNA methyltransferase B; Provisional; Region: PRK14902 881621005610 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 881621005611 putative RNA binding site [nucleotide binding]; other site 881621005612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 881621005613 S-adenosylmethionine binding site [chemical binding]; other site 881621005614 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 881621005615 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 881621005616 putative active site [active] 881621005617 substrate binding site [chemical binding]; other site 881621005618 putative cosubstrate binding site; other site 881621005619 catalytic site [active] 881621005620 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 881621005621 substrate binding site [chemical binding]; other site 881621005622 primosome assembly protein PriA; Validated; Region: PRK05580 881621005623 primosome assembly protein PriA; Validated; Region: PRK05580 881621005624 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 881621005625 ATP binding site [chemical binding]; other site 881621005626 putative Mg++ binding site [ion binding]; other site 881621005627 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621005628 ATP-binding site [chemical binding]; other site 881621005629 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 881621005630 Flavoprotein; Region: Flavoprotein; cl08021 881621005631 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 881621005632 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 881621005633 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 881621005634 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 881621005635 catalytic site [active] 881621005636 G-X2-G-X-G-K; other site 881621005637 hypothetical protein; Provisional; Region: PRK11820 881621005638 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 881621005639 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 881621005640 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 881621005641 Domain of unknown function (DUF814); Region: DUF814; pfam05670 881621005642 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621005643 NADH(P)-binding; Region: NAD_binding_10; pfam13460 881621005644 NAD(P) binding site [chemical binding]; other site 881621005645 active site 881621005646 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 881621005647 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 881621005648 active site 881621005649 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 881621005650 active site 881621005651 dimer interface [polypeptide binding]; other site 881621005652 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 881621005653 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 881621005654 heterodimer interface [polypeptide binding]; other site 881621005655 active site 881621005656 FMN binding site [chemical binding]; other site 881621005657 homodimer interface [polypeptide binding]; other site 881621005658 substrate binding site [chemical binding]; other site 881621005659 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 881621005660 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 881621005661 FAD binding pocket [chemical binding]; other site 881621005662 FAD binding motif [chemical binding]; other site 881621005663 phosphate binding motif [ion binding]; other site 881621005664 beta-alpha-beta structure motif; other site 881621005665 NAD binding pocket [chemical binding]; other site 881621005666 Iron coordination center [ion binding]; other site 881621005667 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 881621005668 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 881621005669 ATP-grasp domain; Region: ATP-grasp_4; cl03087 881621005670 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 881621005671 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 881621005672 ATP-grasp domain; Region: ATP-grasp_4; cl03087 881621005673 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 881621005674 IMP binding site; other site 881621005675 dimer interface [polypeptide binding]; other site 881621005676 interdomain contacts; other site 881621005677 partial ornithine binding site; other site 881621005678 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 881621005679 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 881621005680 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 881621005681 catalytic site [active] 881621005682 subunit interface [polypeptide binding]; other site 881621005683 dihydroorotase; Validated; Region: pyrC; PRK09357 881621005684 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 881621005685 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 881621005686 active site 881621005687 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 881621005688 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 881621005689 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621005690 uracil transporter; Provisional; Region: PRK10720 881621005691 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 881621005692 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 881621005693 active site 881621005694 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 881621005695 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 881621005696 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 881621005697 RNA binding surface [nucleotide binding]; other site 881621005698 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 881621005699 active site 881621005700 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 881621005701 lipoprotein signal peptidase; Provisional; Region: PRK14787 881621005702 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 881621005703 Sulfate transporter family; Region: Sulfate_transp; cl15842 881621005704 multidrug efflux protein; Reviewed; Region: PRK01766 881621005705 MatE; Region: MatE; cl10513 881621005706 MatE; Region: MatE; cl10513 881621005707 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 881621005708 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 881621005709 metal binding site [ion binding]; metal-binding site 881621005710 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 881621005711 ABC-ATPase subunit interface; other site 881621005712 dimer interface [polypeptide binding]; other site 881621005713 putative PBP binding regions; other site 881621005714 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 881621005715 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 881621005716 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 881621005717 Helix-turn-helix domains; Region: HTH; cl00088 881621005718 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 881621005719 C-terminal peptidase (prc); Region: prc; TIGR00225 881621005720 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 881621005721 protein binding site [polypeptide binding]; other site 881621005722 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 881621005723 Catalytic dyad [active] 881621005724 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 881621005725 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 881621005726 metal-binding site [ion binding] 881621005727 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 881621005728 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 881621005729 metal-binding site [ion binding] 881621005730 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 881621005731 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 881621005732 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 881621005733 putative homotetramer interface [polypeptide binding]; other site 881621005734 putative homodimer interface [polypeptide binding]; other site 881621005735 putative allosteric switch controlling residues; other site 881621005736 putative metal binding site [ion binding]; other site 881621005737 putative homodimer-homodimer interface [polypeptide binding]; other site 881621005738 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 881621005739 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 881621005740 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 881621005741 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 881621005742 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 881621005743 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 881621005744 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621005745 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 881621005746 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 881621005747 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 881621005748 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 881621005749 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 881621005750 active site 881621005751 catalytic triad [active] 881621005752 oxyanion hole [active] 881621005753 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 881621005754 Haemolysin-III related; Region: HlyIII; cl03831 881621005755 Helix-turn-helix domains; Region: HTH; cl00088 881621005756 FOG: CBS domain [General function prediction only]; Region: COG0517 881621005757 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 881621005758 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 881621005759 pyruvate phosphate dikinase; Provisional; Region: PRK09279 881621005760 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 881621005761 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 881621005762 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 881621005763 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 881621005764 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 881621005765 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 881621005766 Predicted membrane protein [Function unknown]; Region: COG4129 881621005767 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 881621005768 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 881621005769 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 881621005770 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 881621005771 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 881621005772 Clostridial hydrophobic W; Region: ChW; cl02763 881621005773 Clostridial hydrophobic W; Region: ChW; cl02763 881621005774 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 881621005775 active site 881621005776 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 881621005777 substrate binding site [chemical binding]; other site 881621005778 metal binding site [ion binding]; metal-binding site 881621005779 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 881621005780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621005781 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 881621005782 folate binding site [chemical binding]; other site 881621005783 NADP+ binding site [chemical binding]; other site 881621005784 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 881621005785 dimerization interface [polypeptide binding]; other site 881621005786 active site 881621005787 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 881621005788 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 881621005789 Walker A/P-loop; other site 881621005790 ATP binding site [chemical binding]; other site 881621005791 Q-loop/lid; other site 881621005792 ABC transporter signature motif; other site 881621005793 Walker B; other site 881621005794 D-loop; other site 881621005795 H-loop/switch region; other site 881621005796 ABC transporter; Region: ABC_tran_2; pfam12848 881621005797 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 881621005798 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 881621005799 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 881621005800 Potassium binding sites [ion binding]; other site 881621005801 Cesium cation binding sites [ion binding]; other site 881621005802 manganese transport transcriptional regulator; Provisional; Region: PRK03902 881621005803 Helix-turn-helix domains; Region: HTH; cl00088 881621005804 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 881621005805 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 881621005806 DNA-binding site [nucleotide binding]; DNA binding site 881621005807 RNA-binding motif; other site 881621005808 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 881621005809 RNA/DNA hybrid binding site [nucleotide binding]; other site 881621005810 active site 881621005811 5'-3' exonuclease; Region: 53EXOc; smart00475 881621005812 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 881621005813 active site 881621005814 metal binding site 1 [ion binding]; metal-binding site 881621005815 putative 5' ssDNA interaction site; other site 881621005816 metal binding site 3; metal-binding site 881621005817 metal binding site 2 [ion binding]; metal-binding site 881621005818 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 881621005819 putative DNA binding site [nucleotide binding]; other site 881621005820 putative metal binding site [ion binding]; other site 881621005821 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 881621005822 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 881621005823 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 881621005824 putative active site [active] 881621005825 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 881621005826 xanthine permease; Region: pbuX; TIGR03173 881621005827 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 881621005828 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 881621005829 active site 881621005830 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 881621005831 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 881621005832 active site 881621005833 Zn binding site [ion binding]; other site 881621005834 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 881621005835 THUMP domain; Region: THUMP; cl12076 881621005836 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621005837 cell division protein GpsB; Provisional; Region: PRK14127 881621005838 DivIVA domain; Region: DivI1A_domain; TIGR03544 881621005839 Interactor of ZYG-11; Region: ZYG-11_interact; pfam05884 881621005840 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 881621005841 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 881621005842 Recombination protein U; Region: RecU; cl01314 881621005843 Transglycosylase; Region: Transgly; cl07896 881621005844 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 881621005845 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 881621005846 Transcriptional regulator [Transcription]; Region: LysR; COG0583 881621005847 Helix-turn-helix domains; Region: HTH; cl00088 881621005848 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 881621005849 dimerization interface [polypeptide binding]; other site 881621005850 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 881621005851 dimer interface [polypeptide binding]; other site 881621005852 FMN binding site [chemical binding]; other site 881621005853 NADPH bind site [chemical binding]; other site 881621005854 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 881621005855 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 881621005856 minor groove reading motif; other site 881621005857 helix-hairpin-helix signature motif; other site 881621005858 substrate binding pocket [chemical binding]; other site 881621005859 active site 881621005860 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 881621005861 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 881621005862 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 881621005863 similar to unknown protein, C-terminal part 881621005864 similar to unknown protein, N-terminal part 881621005865 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 881621005866 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 881621005867 putative dimer interface [polypeptide binding]; other site 881621005868 putative anticodon binding site; other site 881621005869 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 881621005870 homodimer interface [polypeptide binding]; other site 881621005871 motif 1; other site 881621005872 motif 2; other site 881621005873 active site 881621005874 motif 3; other site 881621005875 aspartate aminotransferase; Provisional; Region: PRK05764 881621005876 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 881621005877 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621005878 homodimer interface [polypeptide binding]; other site 881621005879 catalytic residue [active] 881621005880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 881621005881 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 881621005882 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 881621005883 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 881621005884 active site 881621005885 substrate binding site [chemical binding]; other site 881621005886 catalytic site [active] 881621005887 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 881621005888 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621005889 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621005890 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 881621005891 tetramerization interface [polypeptide binding]; other site 881621005892 active site 881621005893 pantoate--beta-alanine ligase; Region: panC; TIGR00018 881621005894 Pantoate-beta-alanine ligase; Region: PanC; cd00560 881621005895 active site 881621005896 ATP-binding site [chemical binding]; other site 881621005897 pantoate-binding site; other site 881621005898 HXXH motif; other site 881621005899 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 881621005900 active site 881621005901 oligomerization interface [polypeptide binding]; other site 881621005902 metal binding site [ion binding]; metal-binding site 881621005903 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 881621005904 catalytic residues [active] 881621005905 Helix-turn-helix domains; Region: HTH; cl00088 881621005906 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 881621005907 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 881621005908 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 881621005909 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 881621005910 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 881621005911 active site 881621005912 NTP binding site [chemical binding]; other site 881621005913 metal binding triad [ion binding]; metal-binding site 881621005914 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 881621005915 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 881621005916 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 881621005917 active site 881621005918 dimer interfaces [polypeptide binding]; other site 881621005919 catalytic residues [active] 881621005920 dihydrodipicolinate reductase; Provisional; Region: PRK00048 881621005921 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621005922 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 881621005923 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 881621005924 Uncharacterized conserved protein [Function unknown]; Region: COG1284 881621005925 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 881621005926 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 881621005927 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 881621005928 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 881621005929 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 881621005930 metal binding site [ion binding]; metal-binding site 881621005931 active site 881621005932 I-site; other site 881621005933 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 881621005934 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 881621005935 metal binding site [ion binding]; metal-binding site 881621005936 active site 881621005937 I-site; other site 881621005938 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 881621005939 malate dehydrogenase; Provisional; Region: PRK13529 881621005940 Malic enzyme, N-terminal domain; Region: malic; pfam00390 881621005941 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 881621005942 NAD(P) binding site [chemical binding]; other site 881621005943 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 881621005944 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 881621005945 Pyruvate formate lyase 1; Region: PFL1; cd01678 881621005946 coenzyme A binding site [chemical binding]; other site 881621005947 active site 881621005948 catalytic residues [active] 881621005949 glycine loop; other site 881621005950 HI0933-like protein; Region: HI0933_like; pfam03486 881621005951 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621005952 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621005953 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 881621005954 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 881621005955 hypothetical protein; Provisional; Region: PRK03636 881621005956 UPF0302 domain; Region: UPF0302; pfam08864 881621005957 IDEAL domain; Region: IDEAL; cl07452 881621005958 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 881621005959 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 881621005960 binding surface 881621005961 TPR motif; other site 881621005962 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 881621005963 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 881621005964 hinge; other site 881621005965 active site 881621005966 prephenate dehydrogenase; Validated; Region: PRK06545 881621005967 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621005968 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 881621005969 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 881621005970 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 881621005971 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621005972 homodimer interface [polypeptide binding]; other site 881621005973 catalytic residue [active] 881621005974 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 881621005975 homotrimer interaction site [polypeptide binding]; other site 881621005976 active site 881621005977 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 881621005978 active site 881621005979 dimer interface [polypeptide binding]; other site 881621005980 metal binding site [ion binding]; metal-binding site 881621005981 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 881621005982 Tetramer interface [polypeptide binding]; other site 881621005983 active site 881621005984 FMN-binding site [chemical binding]; other site 881621005985 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 881621005986 active site 881621005987 multimer interface [polypeptide binding]; other site 881621005988 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 881621005989 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 881621005990 substrate binding pocket [chemical binding]; other site 881621005991 chain length determination region; other site 881621005992 substrate-Mg2+ binding site; other site 881621005993 catalytic residues [active] 881621005994 aspartate-rich region 1; other site 881621005995 active site lid residues [active] 881621005996 aspartate-rich region 2; other site 881621005997 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 881621005998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 881621005999 S-adenosylmethionine binding site [chemical binding]; other site 881621006000 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 881621006001 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 881621006002 homodecamer interface [polypeptide binding]; other site 881621006003 GTP cyclohydrolase I; Provisional; Region: PLN03044 881621006004 active site 881621006005 putative catalytic site residues [active] 881621006006 zinc binding site [ion binding]; other site 881621006007 GTP-CH-I/GFRP interaction surface; other site 881621006008 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 881621006009 IHF dimer interface [polypeptide binding]; other site 881621006010 IHF - DNA interface [nucleotide binding]; other site 881621006011 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 881621006012 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 881621006013 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 881621006014 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 881621006015 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621006016 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 881621006017 GTP-binding protein Der; Reviewed; Region: PRK00093 881621006018 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 881621006019 G1 box; other site 881621006020 GTP/Mg2+ binding site [chemical binding]; other site 881621006021 Switch I region; other site 881621006022 G2 box; other site 881621006023 Switch II region; other site 881621006024 G3 box; other site 881621006025 G4 box; other site 881621006026 G5 box; other site 881621006027 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 881621006028 G1 box; other site 881621006029 GTP/Mg2+ binding site [chemical binding]; other site 881621006030 Switch I region; other site 881621006031 G2 box; other site 881621006032 G3 box; other site 881621006033 Switch II region; other site 881621006034 G4 box; other site 881621006035 G5 box; other site 881621006036 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 881621006037 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 881621006038 RNA binding site [nucleotide binding]; other site 881621006039 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 881621006040 RNA binding site [nucleotide binding]; other site 881621006041 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 881621006042 RNA binding site [nucleotide binding]; other site 881621006043 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 881621006044 RNA binding site [nucleotide binding]; other site 881621006045 cytidylate kinase; Provisional; Region: cmk; PRK00023 881621006046 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 881621006047 CMP-binding site; other site 881621006048 The sites determining sugar specificity; other site 881621006049 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 881621006050 active site 881621006051 homotetramer interface [polypeptide binding]; other site 881621006052 homodimer interface [polypeptide binding]; other site 881621006053 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 881621006054 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621006055 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 881621006056 ATP binding site [chemical binding]; other site 881621006057 putative Mg++ binding site [ion binding]; other site 881621006058 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621006059 nucleotide binding region [chemical binding]; other site 881621006060 ATP-binding site [chemical binding]; other site 881621006061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 881621006062 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 881621006063 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 881621006064 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 881621006065 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 881621006066 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 881621006067 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 881621006068 dimerization interface [polypeptide binding]; other site 881621006069 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 881621006070 dimer interface [polypeptide binding]; other site 881621006071 phosphorylation site [posttranslational modification] 881621006072 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621006073 ATP binding site [chemical binding]; other site 881621006074 Mg2+ binding site [ion binding]; other site 881621006075 G-X-G motif; other site 881621006076 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 881621006077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 881621006078 active site 881621006079 phosphorylation site [posttranslational modification] 881621006080 intermolecular recognition site; other site 881621006081 dimerization interface [polypeptide binding]; other site 881621006082 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 881621006083 DNA binding site [nucleotide binding] 881621006084 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 881621006085 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 881621006086 RNA binding surface [nucleotide binding]; other site 881621006087 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 881621006088 active site 881621006089 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 881621006090 ScpA/B protein; Region: ScpA_ScpB; cl00598 881621006091 diaminopimelate decarboxylase; Region: lysA; TIGR01048 881621006092 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 881621006093 active site 881621006094 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 881621006095 substrate binding site [chemical binding]; other site 881621006096 catalytic residues [active] 881621006097 dimer interface [polypeptide binding]; other site 881621006098 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 881621006099 Sulfatase; Region: Sulfatase; cl10460 881621006100 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 881621006101 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 881621006102 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 881621006103 Int/Topo IB signature motif; other site 881621006104 active site 881621006105 ferric uptake regulator; Provisional; Region: fur; PRK09462 881621006106 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 881621006107 metal binding site 2 [ion binding]; metal-binding site 881621006108 putative DNA binding helix; other site 881621006109 metal binding site 1 [ion binding]; metal-binding site 881621006110 dimer interface [polypeptide binding]; other site 881621006111 structural Zn2+ binding site [ion binding]; other site 881621006112 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 881621006113 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 881621006114 ABC-ATPase subunit interface; other site 881621006115 dimer interface [polypeptide binding]; other site 881621006116 putative PBP binding regions; other site 881621006117 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 881621006118 ABC-ATPase subunit interface; other site 881621006119 dimer interface [polypeptide binding]; other site 881621006120 putative PBP binding regions; other site 881621006121 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 881621006122 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 881621006123 putative ligand binding residues [chemical binding]; other site 881621006124 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 881621006125 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 881621006126 Walker A/P-loop; other site 881621006127 ATP binding site [chemical binding]; other site 881621006128 Q-loop/lid; other site 881621006129 ABC transporter signature motif; other site 881621006130 Walker B; other site 881621006131 D-loop; other site 881621006132 H-loop/switch region; other site 881621006133 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 881621006134 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621006135 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 881621006136 Helix-turn-helix domains; Region: HTH; cl00088 881621006137 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 881621006138 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 881621006139 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 881621006140 Helix-turn-helix domains; Region: HTH; cl00088 881621006141 ABC-2 type transporter; Region: ABC2_membrane; cl11417 881621006142 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 881621006143 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 881621006144 Walker A/P-loop; other site 881621006145 ATP binding site [chemical binding]; other site 881621006146 Q-loop/lid; other site 881621006147 ABC transporter signature motif; other site 881621006148 Walker B; other site 881621006149 D-loop; other site 881621006150 H-loop/switch region; other site 881621006151 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 881621006152 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 881621006153 dimer interface [polypeptide binding]; other site 881621006154 ADP-ribose binding site [chemical binding]; other site 881621006155 active site 881621006156 nudix motif; other site 881621006157 metal binding site [ion binding]; metal-binding site 881621006158 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 881621006159 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 881621006160 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 881621006161 active site 881621006162 DNA polymerase IV; Validated; Region: PRK02406 881621006163 DNA binding site [nucleotide binding] 881621006164 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 881621006165 similar to transport protein, C-terminal part 881621006166 similar to transport protein, N-terminal part 881621006167 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 881621006168 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 881621006169 metal binding site [ion binding]; metal-binding site 881621006170 dimer interface [polypeptide binding]; other site 881621006171 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 881621006172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 881621006173 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 881621006174 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 881621006175 metal binding site [ion binding]; metal-binding site 881621006176 dimer interface [polypeptide binding]; other site 881621006177 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 881621006178 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621006179 NAD(P) binding site [chemical binding]; other site 881621006180 active site 881621006181 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 881621006182 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 881621006183 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 881621006184 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 881621006185 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 881621006186 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 881621006187 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 881621006188 Dehydratase family; Region: ILVD_EDD; cl00340 881621006189 6-phosphogluconate dehydratase; Region: edd; TIGR01196 881621006190 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 881621006191 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 881621006192 PYR/PP interface [polypeptide binding]; other site 881621006193 dimer interface [polypeptide binding]; other site 881621006194 TPP binding site [chemical binding]; other site 881621006195 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 881621006196 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 881621006197 TPP-binding site [chemical binding]; other site 881621006198 dimer interface [polypeptide binding]; other site 881621006199 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 881621006200 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 881621006201 putative valine binding site [chemical binding]; other site 881621006202 dimer interface [polypeptide binding]; other site 881621006203 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 881621006204 ketol-acid reductoisomerase; Provisional; Region: PRK05479 881621006205 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621006206 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 881621006207 2-isopropylmalate synthase; Validated; Region: PRK00915 881621006208 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 881621006209 active site 881621006210 catalytic residues [active] 881621006211 metal binding site [ion binding]; metal-binding site 881621006212 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 881621006213 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 881621006214 tartrate dehydrogenase; Provisional; Region: PRK08194 881621006215 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 881621006216 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 881621006217 substrate binding site [chemical binding]; other site 881621006218 ligand binding site [chemical binding]; other site 881621006219 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 881621006220 substrate binding site [chemical binding]; other site 881621006221 threonine dehydratase; Validated; Region: PRK08639 881621006222 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 881621006223 tetramer interface [polypeptide binding]; other site 881621006224 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621006225 catalytic residue [active] 881621006226 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 881621006227 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 881621006228 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 881621006229 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 881621006230 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 881621006231 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 881621006232 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621006233 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621006234 DNA binding site [nucleotide binding] 881621006235 domain linker motif; other site 881621006236 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 881621006237 dimerization interface [polypeptide binding]; other site 881621006238 ligand binding site [chemical binding]; other site 881621006239 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 881621006240 intersubunit interface [polypeptide binding]; other site 881621006241 active site 881621006242 catalytic residue [active] 881621006243 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 881621006244 Helix-turn-helix domains; Region: HTH; cl00088 881621006245 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 881621006246 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 881621006247 active pocket/dimerization site; other site 881621006248 active site 881621006249 phosphorylation site [posttranslational modification] 881621006250 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 881621006251 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 881621006252 putative active site [active] 881621006253 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 881621006254 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 881621006255 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 881621006256 dimer interface [polypeptide binding]; other site 881621006257 active site 881621006258 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 881621006259 dimer interface [polypeptide binding]; other site 881621006260 active site 881621006261 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 881621006262 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 881621006263 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 881621006264 active site 881621006265 phosphorylation site [posttranslational modification] 881621006266 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 881621006267 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621006268 DNA-binding site [nucleotide binding]; DNA binding site 881621006269 UTRA domain; Region: UTRA; cl01230 881621006270 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 881621006271 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621006272 DNA-binding site [nucleotide binding]; DNA binding site 881621006273 UTRA domain; Region: UTRA; cl01230 881621006274 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 881621006275 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 881621006276 active site 881621006277 catalytic tetrad [active] 881621006278 acetolactate synthase; Reviewed; Region: PRK08617 881621006279 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 881621006280 PYR/PP interface [polypeptide binding]; other site 881621006281 dimer interface [polypeptide binding]; other site 881621006282 TPP binding site [chemical binding]; other site 881621006283 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 881621006284 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 881621006285 TPP-binding site [chemical binding]; other site 881621006286 dimer interface [polypeptide binding]; other site 881621006287 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 881621006288 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 881621006289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 881621006290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621006291 putative PBP binding loops; other site 881621006292 dimer interface [polypeptide binding]; other site 881621006293 ABC-ATPase subunit interface; other site 881621006294 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 881621006295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621006296 dimer interface [polypeptide binding]; other site 881621006297 conserved gate region; other site 881621006298 ABC-ATPase subunit interface; other site 881621006299 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 881621006300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 881621006301 active site 881621006302 phosphorylation site [posttranslational modification] 881621006303 intermolecular recognition site; other site 881621006304 dimerization interface [polypeptide binding]; other site 881621006305 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621006306 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 881621006307 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 881621006308 Histidine kinase; Region: His_kinase; pfam06580 881621006309 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621006310 ATP binding site [chemical binding]; other site 881621006311 Mg2+ binding site [ion binding]; other site 881621006312 G-X-G motif; other site 881621006313 Protein of unknown function, DUF624; Region: DUF624; cl02369 881621006314 Protein of unknown function (DUF1237); Region: DUF1237; cl15402 881621006315 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 881621006316 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 881621006317 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 881621006318 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 881621006319 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 881621006320 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 881621006321 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 881621006322 DNA-binding site [nucleotide binding]; DNA binding site 881621006323 RNA-binding motif; other site 881621006324 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 881621006325 active site 881621006326 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 881621006327 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 881621006328 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 881621006329 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 881621006330 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 881621006331 HIGH motif; other site 881621006332 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 881621006333 active site 881621006334 KMSKS motif; other site 881621006335 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 881621006336 tRNA binding surface [nucleotide binding]; other site 881621006337 anticodon binding site; other site 881621006338 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 881621006339 DivIVA protein; Region: DivIVA; pfam05103 881621006340 DivIVA domain; Region: DivI1A_domain; TIGR03544 881621006341 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 881621006342 Helix-turn-helix domains; Region: HTH; cl00088 881621006343 3H domain; Region: 3H; pfam02829 881621006344 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 881621006345 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 881621006346 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 881621006347 catalytic residue [active] 881621006348 L-aspartate oxidase; Provisional; Region: PRK08071 881621006349 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621006350 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 881621006351 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 881621006352 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 881621006353 dimerization interface [polypeptide binding]; other site 881621006354 active site 881621006355 Quinolinate synthetase A protein; Region: NadA; cl00420 881621006356 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 881621006357 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 881621006358 RNA binding surface [nucleotide binding]; other site 881621006359 YGGT family; Region: YGGT; cl00508 881621006360 Protein of unknown function (DUF552); Region: DUF552; cl00775 881621006361 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 881621006362 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 881621006363 catalytic residue [active] 881621006364 cell division protein FtsZ; Validated; Region: PRK09330 881621006365 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 881621006366 nucleotide binding site [chemical binding]; other site 881621006367 SulA interaction site; other site 881621006368 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 881621006369 Cell division protein FtsA; Region: FtsA; cl11496 881621006370 Cell division protein FtsA; Region: FtsA; cl11496 881621006371 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 881621006372 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 881621006373 Cell division protein FtsQ; Region: FtsQ; pfam03799 881621006374 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 881621006375 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 881621006376 active site 881621006377 homodimer interface [polypeptide binding]; other site 881621006378 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 881621006379 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 881621006380 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 881621006381 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 881621006382 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 881621006383 Mg++ binding site [ion binding]; other site 881621006384 putative catalytic motif [active] 881621006385 putative substrate binding site [chemical binding]; other site 881621006386 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 881621006387 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 881621006388 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 881621006389 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 881621006390 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 881621006391 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 881621006392 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 881621006393 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 881621006394 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 881621006395 Septum formation initiator; Region: DivIC; cl11433 881621006396 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 881621006397 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621006398 cell division protein MraZ; Reviewed; Region: PRK00326 881621006399 MraZ protein; Region: MraZ; pfam02381 881621006400 MraZ protein; Region: MraZ; pfam02381 881621006401 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621006402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621006403 putative substrate translocation pore; other site 881621006404 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 881621006405 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 881621006406 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 881621006407 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 881621006408 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 881621006409 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621006410 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 881621006411 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 881621006412 hypothetical protein; Provisional; Region: PRK13670 881621006413 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 881621006414 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 881621006415 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 881621006416 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621006417 AAA domain; Region: AAA_21; pfam13304 881621006418 Walker A/P-loop; other site 881621006419 ATP binding site [chemical binding]; other site 881621006420 Q-loop/lid; other site 881621006421 ABC transporter signature motif; other site 881621006422 Walker B; other site 881621006423 D-loop; other site 881621006424 H-loop/switch region; other site 881621006425 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 881621006426 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 881621006427 protein binding site [polypeptide binding]; other site 881621006428 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 881621006429 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 881621006430 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 881621006431 active site 881621006432 (T/H)XGH motif; other site 881621006433 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 881621006434 S-adenosylmethionine binding site [chemical binding]; other site 881621006435 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 881621006436 Protein of unknown function (DUF964); Region: DUF964; cl01483 881621006437 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 881621006438 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 881621006439 UbiA prenyltransferase family; Region: UbiA; cl00337 881621006440 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 881621006441 Ion transport protein; Region: Ion_trans; pfam00520 881621006442 Ion channel; Region: Ion_trans_2; cl11596 881621006443 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 881621006444 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 881621006445 similar to Peptide methionine sulfoxide reductase MsrB internal part 881621006446 similar to Peptide methionine sulfoxide reductase MsrB C-terminal part 881621006447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 881621006448 MOSC domain; Region: MOSC; pfam03473 881621006449 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 881621006450 Bacterial Ig-like domain; Region: Big_5; cl01012 881621006451 Copper resistance protein D; Region: CopD; cl00563 881621006452 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 881621006453 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 881621006454 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 881621006455 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 881621006456 active site 881621006457 similar to soluble internalin, partial 881621006458 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621006459 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 881621006460 LRR adjacent; Region: LRR_adjacent; pfam08191 881621006461 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 881621006462 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 881621006463 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 881621006464 ring oligomerisation interface [polypeptide binding]; other site 881621006465 ATP/Mg binding site [chemical binding]; other site 881621006466 stacking interactions; other site 881621006467 hinge regions; other site 881621006468 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 881621006469 oligomerisation interface [polypeptide binding]; other site 881621006470 mobile loop; other site 881621006471 roof hairpin; other site 881621006472 CAAX protease self-immunity; Region: Abi; cl00558 881621006473 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 881621006474 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 881621006475 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621006476 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 881621006477 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 881621006478 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 881621006479 ABC transporter; Region: ABC_tran_2; pfam12848 881621006480 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 881621006481 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621006482 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 881621006483 UGMP family protein; Validated; Region: PRK09604 881621006484 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 881621006485 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 881621006486 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 881621006487 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621006488 Coenzyme A binding pocket [chemical binding]; other site 881621006489 Glycoprotease family; Region: Peptidase_M22; pfam00814 881621006490 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 881621006491 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 881621006492 CrcB-like protein; Region: CRCB; cl09114 881621006493 CrcB-like protein; Region: CRCB; cl09114 881621006494 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 881621006495 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 881621006496 active site 881621006497 substrate binding site [chemical binding]; other site 881621006498 ATP binding site [chemical binding]; other site 881621006499 Putative peptidoglycan linked protein (LPXTG motif), C-terminal part 881621006500 putative peptidoglycan bound protein (LPXTG motif),N-terminal part 881621006501 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621006502 non-specific DNA binding site [nucleotide binding]; other site 881621006503 salt bridge; other site 881621006504 sequence-specific DNA binding site [nucleotide binding]; other site 881621006505 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 881621006506 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 881621006507 MatE; Region: MatE; cl10513 881621006508 MatE; Region: MatE; cl10513 881621006509 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 881621006510 Helix-turn-helix domains; Region: HTH; cl00088 881621006511 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621006512 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 881621006513 substrate binding pocket [chemical binding]; other site 881621006514 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 881621006515 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 881621006516 ANP binding site [chemical binding]; other site 881621006517 Substrate Binding Site II [chemical binding]; other site 881621006518 Substrate Binding Site I [chemical binding]; other site 881621006519 argininosuccinate lyase; Provisional; Region: PRK00855 881621006520 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 881621006521 active sites [active] 881621006522 tetramer interface [polypeptide binding]; other site 881621006523 BCCT family transporter; Region: BCCT; cl00569 881621006524 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 881621006525 active site 881621006526 intersubunit interface [polypeptide binding]; other site 881621006527 Zn2+ binding site [ion binding]; other site 881621006528 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 881621006529 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 881621006530 putative substrate binding site [chemical binding]; other site 881621006531 putative ATP binding site [chemical binding]; other site 881621006532 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 881621006533 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 881621006534 P-loop; other site 881621006535 active site 881621006536 phosphorylation site [posttranslational modification] 881621006537 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621006538 active site 881621006539 phosphorylation site [posttranslational modification] 881621006540 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 881621006541 PRD domain; Region: PRD; cl15445 881621006542 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 881621006543 P-loop; other site 881621006544 active site 881621006545 phosphorylation site [posttranslational modification] 881621006546 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 881621006547 active site 881621006548 phosphorylation site [posttranslational modification] 881621006549 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 881621006550 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 881621006551 WxL domain surface cell wall-binding; Region: WxL; pfam13731 881621006552 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 881621006553 similar to internalin, peptidoglycan bound protein (LPxTG motif, partial 881621006554 similar to unknown proteins, N-terminal part 881621006555 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 881621006556 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621006557 DNA-binding site [nucleotide binding]; DNA binding site 881621006558 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 881621006559 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621006560 homodimer interface [polypeptide binding]; other site 881621006561 catalytic residue [active] 881621006562 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 881621006563 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 881621006564 active site 881621006565 multimer interface [polypeptide binding]; other site 881621006566 imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188 881621006567 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 881621006568 predicted active site [active] 881621006569 catalytic triad [active] 881621006570 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 881621006571 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 881621006572 FeoA domain; Region: FeoA; cl00838 881621006573 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 881621006574 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 881621006575 G1 box; other site 881621006576 GTP/Mg2+ binding site [chemical binding]; other site 881621006577 Switch I region; other site 881621006578 G2 box; other site 881621006579 G3 box; other site 881621006580 Switch II region; other site 881621006581 G4 box; other site 881621006582 G5 box; other site 881621006583 Nucleoside recognition; Region: Gate; cl00486 881621006584 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 881621006585 Nucleoside recognition; Region: Gate; cl00486 881621006586 Similar to ABC transporter, ATP-binding protein. Truncated, C-terminal part 881621006587 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 881621006588 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 881621006589 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 881621006590 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 881621006591 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 881621006592 putative active site [active] 881621006593 putative metal binding site [ion binding]; other site 881621006594 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 881621006595 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 881621006596 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 881621006597 dimer interface [polypeptide binding]; other site 881621006598 FMN binding site [chemical binding]; other site 881621006599 NADPH bind site [chemical binding]; other site 881621006600 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 881621006601 Chlorite dismutase; Region: Chlor_dismutase; cl01280 881621006602 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621006603 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 881621006604 Walker A/P-loop; other site 881621006605 ATP binding site [chemical binding]; other site 881621006606 Q-loop/lid; other site 881621006607 ABC transporter signature motif; other site 881621006608 Walker B; other site 881621006609 D-loop; other site 881621006610 H-loop/switch region; other site 881621006611 FtsX-like permease family; Region: FtsX; cl15850 881621006612 FtsX-like permease family; Region: FtsX; cl15850 881621006613 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621006614 Coenzyme A binding pocket [chemical binding]; other site 881621006615 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 881621006616 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 881621006617 active site 881621006618 substrate binding site [chemical binding]; other site 881621006619 metal binding site [ion binding]; metal-binding site 881621006620 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 881621006621 YbbR-like protein; Region: YbbR; pfam07949 881621006622 YbbR-like protein; Region: YbbR; pfam07949 881621006623 YbbR-like protein; Region: YbbR; pfam07949 881621006624 Uncharacterized conserved protein [Function unknown]; Region: COG1624 881621006625 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 881621006626 maltose phosphorylase; Provisional; Region: PRK13807 881621006627 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 881621006628 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 881621006629 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 881621006630 Predicted integral membrane protein [Function unknown]; Region: COG5521 881621006631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621006632 dimer interface [polypeptide binding]; other site 881621006633 conserved gate region; other site 881621006634 putative PBP binding loops; other site 881621006635 ABC-ATPase subunit interface; other site 881621006636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621006637 dimer interface [polypeptide binding]; other site 881621006638 conserved gate region; other site 881621006639 putative PBP binding loops; other site 881621006640 ABC-ATPase subunit interface; other site 881621006641 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 881621006642 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 881621006643 maltodextrin glucosidase; Provisional; Region: PRK10785 881621006644 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 881621006645 homodimer interface [polypeptide binding]; other site 881621006646 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 881621006647 active site 881621006648 homodimer interface [polypeptide binding]; other site 881621006649 catalytic site [active] 881621006650 CAAX protease self-immunity; Region: Abi; cl00558 881621006651 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621006652 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621006653 DNA binding site [nucleotide binding] 881621006654 domain linker motif; other site 881621006655 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 881621006656 ligand binding site [chemical binding]; other site 881621006657 dimerization interface [polypeptide binding]; other site 881621006658 Amino acid permease; Region: AA_permease_2; pfam13520 881621006659 similar to other protein, C-terminal part 881621006660 similar to other protein, N-terminal part 881621006661 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621006662 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 881621006663 ligand binding site [chemical binding]; other site 881621006664 flexible hinge region; other site 881621006665 Helix-turn-helix domains; Region: HTH; cl00088 881621006666 hypothetical protein; Provisional; Region: PRK08185 881621006667 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 881621006668 intersubunit interface [polypeptide binding]; other site 881621006669 active site 881621006670 zinc binding site [ion binding]; other site 881621006671 Na+ binding site [ion binding]; other site 881621006672 hypothetical protein; Provisional; Region: PRK08185 881621006673 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 881621006674 intersubunit interface [polypeptide binding]; other site 881621006675 active site 881621006676 zinc binding site [ion binding]; other site 881621006677 Na+ binding site [ion binding]; other site 881621006678 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 881621006679 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 881621006680 P-loop; other site 881621006681 active site 881621006682 phosphorylation site [posttranslational modification] 881621006683 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621006684 active site 881621006685 phosphorylation site [posttranslational modification] 881621006686 Helix-turn-helix domains; Region: HTH; cl00088 881621006687 PRD domain; Region: PRD; cl15445 881621006688 PRD domain; Region: PRD; cl15445 881621006689 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 881621006690 P-loop; other site 881621006691 active site 881621006692 phosphorylation site [posttranslational modification] 881621006693 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 881621006694 This subfamily is involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity. In eubacteria and archaea, the typical organization consists of one ABC and one or two IMs. Eukaryote systems of the ABCA subfamily...; Region: ABC_putative_ATPase; cd03269 881621006695 Walker A/P-loop; other site 881621006696 ATP binding site [chemical binding]; other site 881621006697 Q-loop/lid; other site 881621006698 ABC transporter signature motif; other site 881621006699 Walker B; other site 881621006700 D-loop; other site 881621006701 H-loop/switch region; other site 881621006702 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 881621006703 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 881621006704 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 881621006705 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621006706 Coenzyme A binding pocket [chemical binding]; other site 881621006707 Transcriptional regulators [Transcription]; Region: GntR; COG1802 881621006708 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 881621006709 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 881621006710 Transcriptional regulator [Transcription]; Region: LysR; COG0583 881621006711 Helix-turn-helix domains; Region: HTH; cl00088 881621006712 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 881621006713 putative dimerization interface [polypeptide binding]; other site 881621006714 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 881621006715 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 881621006716 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 881621006717 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 881621006718 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 881621006719 catalytic residues [active] 881621006720 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 881621006721 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 881621006722 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 881621006723 dimer interface [polypeptide binding]; other site 881621006724 putative radical transfer pathway; other site 881621006725 diiron center [ion binding]; other site 881621006726 tyrosyl radical; other site 881621006727 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 881621006728 Class I ribonucleotide reductase; Region: RNR_I; cd01679 881621006729 active site 881621006730 dimer interface [polypeptide binding]; other site 881621006731 catalytic residues [active] 881621006732 effector binding site; other site 881621006733 R2 peptide binding site; other site 881621006734 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 881621006735 CsbD-like; Region: CsbD; cl15799 881621006736 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 881621006737 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621006738 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 881621006739 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 881621006740 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 881621006741 DNA interaction; other site 881621006742 Metal-binding active site; metal-binding site 881621006743 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 881621006744 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 881621006745 conserved cys residue [active] 881621006746 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 881621006747 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 881621006748 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621006749 Cupin domain; Region: Cupin_2; cl09118 881621006750 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621006751 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 881621006752 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621006753 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621006754 Helix-turn-helix domains; Region: HTH; cl00088 881621006755 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 881621006756 ligand binding site [chemical binding]; other site 881621006757 flexible hinge region; other site 881621006758 Helix-turn-helix domains; Region: HTH; cl00088 881621006759 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 881621006760 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 881621006761 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 881621006762 dimer interface [polypeptide binding]; other site 881621006763 active site 881621006764 metal binding site [ion binding]; metal-binding site 881621006765 glutathione binding site [chemical binding]; other site 881621006766 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 881621006767 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 881621006768 FMN binding site [chemical binding]; other site 881621006769 substrate binding site [chemical binding]; other site 881621006770 putative catalytic residue [active] 881621006771 similar to antiporter proteins, C-terminal part 881621006772 similar to antiporter proteins, N-terminal part 881621006773 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 881621006774 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 881621006775 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 881621006776 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 881621006777 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621006778 Walker A motif; other site 881621006779 ATP binding site [chemical binding]; other site 881621006780 Walker B motif; other site 881621006781 arginine finger; other site 881621006782 Helix-turn-helix domains; Region: HTH; cl00088 881621006783 similar putative peptidoglycan linked protein (LPXTG motif), C-terminal part 881621006784 similar putative peptidoglycan linked protein (LPXTG motif), central part 881621006785 similar putative peptidoglycan linked protein (LPXTG motif), N-terminal part 881621006786 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 881621006787 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 881621006788 Collagen binding domain; Region: Collagen_bind; pfam05737 881621006789 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 881621006790 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 881621006791 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 881621006792 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 881621006793 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 881621006794 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 881621006795 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 881621006796 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 881621006797 Collagen binding domain; Region: Collagen_bind; pfam05737 881621006798 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 881621006799 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 881621006800 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 881621006801 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 881621006802 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 881621006803 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 881621006804 active site 881621006805 catalytic site [active] 881621006806 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 881621006807 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 881621006808 Walker A/P-loop; other site 881621006809 ATP binding site [chemical binding]; other site 881621006810 Q-loop/lid; other site 881621006811 ABC transporter signature motif; other site 881621006812 Walker B; other site 881621006813 D-loop; other site 881621006814 H-loop/switch region; other site 881621006815 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 881621006816 ABC-ATPase subunit interface; other site 881621006817 dimer interface [polypeptide binding]; other site 881621006818 putative PBP binding regions; other site 881621006819 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 881621006820 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 881621006821 intersubunit interface [polypeptide binding]; other site 881621006822 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 881621006823 heme-binding site [chemical binding]; other site 881621006824 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 881621006825 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 881621006826 heme-binding site [chemical binding]; other site 881621006827 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 881621006828 heme-binding site [chemical binding]; other site 881621006829 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 881621006830 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 881621006831 heme-binding site [chemical binding]; other site 881621006832 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 881621006833 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 881621006834 oligoendopeptidase F; Region: pepF; TIGR00181 881621006835 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 881621006836 active site 881621006837 Zn binding site [ion binding]; other site 881621006838 Competence protein CoiA-like family; Region: CoiA; cl11541 881621006839 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 881621006840 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 881621006841 ArsC family; Region: ArsC; pfam03960 881621006842 putative catalytic residues [active] 881621006843 thiol/disulfide switch; other site 881621006844 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 881621006845 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 881621006846 Walker A/P-loop; other site 881621006847 ATP binding site [chemical binding]; other site 881621006848 Q-loop/lid; other site 881621006849 ABC transporter signature motif; other site 881621006850 Walker B; other site 881621006851 D-loop; other site 881621006852 H-loop/switch region; other site 881621006853 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 881621006854 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 881621006855 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 881621006856 Walker A/P-loop; other site 881621006857 ATP binding site [chemical binding]; other site 881621006858 Q-loop/lid; other site 881621006859 ABC transporter signature motif; other site 881621006860 Walker B; other site 881621006861 D-loop; other site 881621006862 H-loop/switch region; other site 881621006863 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 881621006864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621006865 dimer interface [polypeptide binding]; other site 881621006866 conserved gate region; other site 881621006867 putative PBP binding loops; other site 881621006868 ABC-ATPase subunit interface; other site 881621006869 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 881621006870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621006871 dimer interface [polypeptide binding]; other site 881621006872 conserved gate region; other site 881621006873 putative PBP binding loops; other site 881621006874 ABC-ATPase subunit interface; other site 881621006875 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 881621006876 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 881621006877 peptide binding site [polypeptide binding]; other site 881621006878 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 881621006879 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 881621006880 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 881621006881 active site 881621006882 HIGH motif; other site 881621006883 dimer interface [polypeptide binding]; other site 881621006884 KMSKS motif; other site 881621006885 OsmC-like protein; Region: OsmC; cl00767 881621006886 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 881621006887 Helix-turn-helix domains; Region: HTH; cl00088 881621006888 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 881621006889 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 881621006890 dimer interface [polypeptide binding]; other site 881621006891 active site 881621006892 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 881621006893 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 881621006894 dimer interface [polypeptide binding]; other site 881621006895 active site 881621006896 CoA binding pocket [chemical binding]; other site 881621006897 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 881621006898 SH3-like domain; Region: SH3_8; pfam13457 881621006899 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 881621006900 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621006901 catalytic core [active] 881621006902 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621006903 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 881621006904 Clp amino terminal domain; Region: Clp_N; pfam02861 881621006905 Clp amino terminal domain; Region: Clp_N; pfam02861 881621006906 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621006907 Walker A motif; other site 881621006908 ATP binding site [chemical binding]; other site 881621006909 Walker B motif; other site 881621006910 arginine finger; other site 881621006911 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621006912 Walker A motif; other site 881621006913 ATP binding site [chemical binding]; other site 881621006914 Walker B motif; other site 881621006915 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 881621006916 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 881621006917 similar to unknown protein, C-terminal part 881621006918 similar to unknown protein, N-terminal part 881621006919 Predicted acetyltransferase [General function prediction only]; Region: COG3393 881621006920 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 881621006921 ferrochelatase; Provisional; Region: PRK12435 881621006922 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 881621006923 C-terminal domain interface [polypeptide binding]; other site 881621006924 active site 881621006925 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 881621006926 active site 881621006927 N-terminal domain interface [polypeptide binding]; other site 881621006928 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 881621006929 substrate binding site [chemical binding]; other site 881621006930 active site 881621006931 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 881621006932 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 881621006933 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 881621006934 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 881621006935 Walker A/P-loop; other site 881621006936 ATP binding site [chemical binding]; other site 881621006937 Q-loop/lid; other site 881621006938 ABC transporter signature motif; other site 881621006939 Walker B; other site 881621006940 D-loop; other site 881621006941 H-loop/switch region; other site 881621006942 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 881621006943 HIT family signature motif; other site 881621006944 catalytic residue [active] 881621006945 YtxH-like protein; Region: YtxH; cl02079 881621006946 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 881621006947 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 881621006948 SurA N-terminal domain; Region: SurA_N_3; cl07813 881621006949 PPIC-type PPIASE domain; Region: Rotamase; cl08278 881621006950 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 881621006951 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 881621006952 generic binding surface II; other site 881621006953 generic binding surface I; other site 881621006954 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 881621006955 Uncharacterized conserved protein [Function unknown]; Region: COG4717 881621006956 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 881621006957 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 881621006958 active site 881621006959 metal binding site [ion binding]; metal-binding site 881621006960 DNA binding site [nucleotide binding] 881621006961 Protein of unknown function (DUF964); Region: DUF964; cl01483 881621006962 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 881621006963 fumarate hydratase; Reviewed; Region: fumC; PRK00485 881621006964 Class II fumarases; Region: Fumarase_classII; cd01362 881621006965 active site 881621006966 tetramer interface [polypeptide binding]; other site 881621006967 ABC-2 type transporter; Region: ABC2_membrane; cl11417 881621006968 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 881621006969 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621006970 Walker A/P-loop; other site 881621006971 ATP binding site [chemical binding]; other site 881621006972 Q-loop/lid; other site 881621006973 ABC transporter signature motif; other site 881621006974 Walker B; other site 881621006975 D-loop; other site 881621006976 H-loop/switch region; other site 881621006977 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 881621006978 Transglycosylase; Region: Transgly; cl07896 881621006979 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 881621006980 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 881621006981 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 881621006982 Low molecular weight phosphatase family; Region: LMWPc; cl00105 881621006983 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 881621006984 Cation efflux family; Region: Cation_efflux; cl00316 881621006985 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 881621006986 Domain of unknown function DUF21; Region: DUF21; pfam01595 881621006987 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 881621006988 Transporter associated domain; Region: CorC_HlyC; cl08393 881621006989 Transcriptional regulator [Transcription]; Region: LysR; COG0583 881621006990 Helix-turn-helix domains; Region: HTH; cl00088 881621006991 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 881621006992 putative dimerization interface [polypeptide binding]; other site 881621006993 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 881621006994 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 881621006995 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 881621006996 active site 881621006997 FMN binding site [chemical binding]; other site 881621006998 substrate binding site [chemical binding]; other site 881621006999 putative catalytic residue [active] 881621007000 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 881621007001 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 881621007002 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 881621007003 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 881621007004 shikimate binding site; other site 881621007005 NAD(P) binding site [chemical binding]; other site 881621007006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621007007 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621007008 putative substrate translocation pore; other site 881621007009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621007010 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621007011 putative substrate translocation pore; other site 881621007012 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 881621007013 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 881621007014 DNA binding site [nucleotide binding] 881621007015 active site 881621007016 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 881621007017 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 881621007018 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621007019 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621007020 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 881621007021 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 881621007022 active site 881621007023 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 881621007024 putative dimer interface [polypeptide binding]; other site 881621007025 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 881621007026 ligand binding site [chemical binding]; other site 881621007027 Zn binding site [ion binding]; other site 881621007028 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 881621007029 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 881621007030 active site 881621007031 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 881621007032 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 881621007033 active site 881621007034 catalytic tetrad [active] 881621007035 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 881621007036 Phosphate transporter family; Region: PHO4; cl00396 881621007037 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 881621007038 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 881621007039 substrate binding pocket [chemical binding]; other site 881621007040 membrane-bound complex binding site; other site 881621007041 hinge residues; other site 881621007042 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 881621007043 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621007044 dimer interface [polypeptide binding]; other site 881621007045 conserved gate region; other site 881621007046 putative PBP binding loops; other site 881621007047 ABC-ATPase subunit interface; other site 881621007048 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 881621007049 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 881621007050 Walker A/P-loop; other site 881621007051 ATP binding site [chemical binding]; other site 881621007052 Q-loop/lid; other site 881621007053 ABC transporter signature motif; other site 881621007054 Walker B; other site 881621007055 D-loop; other site 881621007056 H-loop/switch region; other site 881621007057 aspartate aminotransferase; Provisional; Region: PRK06348 881621007058 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 881621007059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621007060 homodimer interface [polypeptide binding]; other site 881621007061 catalytic residue [active] 881621007062 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 881621007063 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621007064 motif II; other site 881621007065 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 881621007066 intracellular protease, PfpI family; Region: PfpI; TIGR01382 881621007067 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 881621007068 proposed catalytic triad [active] 881621007069 conserved cys residue [active] 881621007070 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 881621007071 methionine cluster; other site 881621007072 active site 881621007073 phosphorylation site [posttranslational modification] 881621007074 metal binding site [ion binding]; metal-binding site 881621007075 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621007076 Coenzyme A binding pocket [chemical binding]; other site 881621007077 Domain of unknown function DUF59; Region: DUF59; cl00941 881621007078 esterase; Provisional; Region: PRK10566 881621007079 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621007080 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 881621007081 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621007082 Uncharacterized conserved protein [Function unknown]; Region: COG1284 881621007083 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 881621007084 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 881621007085 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 881621007086 similar to unknown protein, C-terminal part 881621007087 Similar to unknown protein, N-terminal part 881621007088 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 881621007089 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621007090 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 881621007091 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 881621007092 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 881621007093 IDEAL domain; Region: IDEAL; cl07452 881621007094 ComK protein; Region: ComK; cl11560 881621007095 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621007096 non-specific DNA binding site [nucleotide binding]; other site 881621007097 salt bridge; other site 881621007098 sequence-specific DNA binding site [nucleotide binding]; other site 881621007099 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621007100 active site 881621007101 phosphorylation site [posttranslational modification] 881621007102 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 881621007103 P-loop; other site 881621007104 active site 881621007105 phosphorylation site [posttranslational modification] 881621007106 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 881621007107 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 881621007108 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 881621007109 putative substrate binding site [chemical binding]; other site 881621007110 putative ATP binding site [chemical binding]; other site 881621007111 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 881621007112 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621007113 DNA-binding site [nucleotide binding]; DNA binding site 881621007114 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 881621007115 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 881621007116 trimer interface [polypeptide binding]; other site 881621007117 active site 881621007118 G bulge; other site 881621007119 Protein of unknown function (DUF523); Region: DUF523; cl00733 881621007120 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 881621007121 Helix-turn-helix domains; Region: HTH; cl00088 881621007122 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 881621007123 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 881621007124 substrate binding site [chemical binding]; other site 881621007125 ATP binding site [chemical binding]; other site 881621007126 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 881621007127 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 881621007128 RNA binding surface [nucleotide binding]; other site 881621007129 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 881621007130 active site 881621007131 uracil binding [chemical binding]; other site 881621007132 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 881621007133 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 881621007134 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 881621007135 active site 881621007136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621007137 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621007138 putative substrate translocation pore; other site 881621007139 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 881621007140 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 881621007141 active site 881621007142 trimer interface [polypeptide binding]; other site 881621007143 allosteric site; other site 881621007144 active site lid [active] 881621007145 hexamer (dimer of trimers) interface [polypeptide binding]; other site 881621007146 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 881621007147 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621007148 active site 881621007149 motif I; other site 881621007150 motif II; other site 881621007151 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 881621007152 Predicted membrane protein [Function unknown]; Region: COG1511 881621007153 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 881621007154 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 881621007155 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 881621007156 ABC-2 type transporter; Region: ABC2_membrane; cl11417 881621007157 Predicted transcriptional regulator [Transcription]; Region: COG1959 881621007158 Helix-turn-helix domains; Region: HTH; cl00088 881621007159 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 881621007160 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 881621007161 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 881621007162 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621007163 catalytic residue [active] 881621007164 Helix-turn-helix domains; Region: HTH; cl00088 881621007165 Helix-turn-helix domains; Region: HTH; cl00088 881621007166 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 881621007167 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 881621007168 Helix-turn-helix domains; Region: HTH; cl00088 881621007169 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 881621007170 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 881621007171 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 881621007172 active site 881621007173 dimer interface [polypeptide binding]; other site 881621007174 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 881621007175 dimer interface [polypeptide binding]; other site 881621007176 active site 881621007177 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 881621007178 nudix motif; other site 881621007179 general stress protein 13; Validated; Region: PRK08059 881621007180 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 881621007181 RNA binding site [nucleotide binding]; other site 881621007182 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 881621007183 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 881621007184 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621007185 homodimer interface [polypeptide binding]; other site 881621007186 catalytic residue [active] 881621007187 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 881621007188 FtsX-like permease family; Region: FtsX; cl15850 881621007189 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621007190 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 881621007191 Walker A/P-loop; other site 881621007192 ATP binding site [chemical binding]; other site 881621007193 Q-loop/lid; other site 881621007194 ABC transporter signature motif; other site 881621007195 Walker B; other site 881621007196 D-loop; other site 881621007197 H-loop/switch region; other site 881621007198 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 881621007199 active site 881621007200 P-loop; other site 881621007201 phosphorylation site [posttranslational modification] 881621007202 similar to aspartate kinase, N-terminal part 881621007203 similar to aspartate kinase, central part 881621007204 similar to aspartate kinase, C-terminal part 881621007205 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 881621007206 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 881621007207 active site 881621007208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621007209 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621007210 putative substrate translocation pore; other site 881621007211 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 881621007212 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 881621007213 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 881621007214 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 881621007215 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 881621007216 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 881621007217 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 881621007218 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 881621007219 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 881621007220 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 881621007221 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 881621007222 CoenzymeA binding site [chemical binding]; other site 881621007223 subunit interaction site [polypeptide binding]; other site 881621007224 PHB binding site; other site 881621007225 Divergent PAP2 family; Region: DUF212; cl00855 881621007226 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 881621007227 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 881621007228 active site 881621007229 catalytic tetrad [active] 881621007230 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 881621007231 Cl- selectivity filter; other site 881621007232 Cl- binding residues [ion binding]; other site 881621007233 pore gating glutamate residue; other site 881621007234 dimer interface [polypeptide binding]; other site 881621007235 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621007236 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 881621007237 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 881621007238 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 881621007239 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 881621007240 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621007241 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 881621007242 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 881621007243 Protein of unknown function (DUF1462); Region: DUF1462; cl11552 881621007244 NifU-like domain; Region: NifU; cl00484 881621007245 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 881621007246 Domain of unknown function DUF21; Region: DUF21; pfam01595 881621007247 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 881621007248 Transporter associated domain; Region: CorC_HlyC; cl08393 881621007249 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 881621007250 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621007251 Coenzyme A binding pocket [chemical binding]; other site 881621007252 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 881621007253 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621007254 active site 881621007255 motif I; other site 881621007256 motif II; other site 881621007257 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621007258 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 881621007259 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 881621007260 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 881621007261 active site 881621007262 metal binding site [ion binding]; metal-binding site 881621007263 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 881621007264 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 881621007265 Protein of unknown function (DUF1634); Region: DUF1634; cl01741 881621007266 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 881621007267 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 881621007268 active site 881621007269 catalytic tetrad [active] 881621007270 Protein of unknown function DUF72; Region: DUF72; cl00777 881621007271 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 881621007272 FeS assembly protein SufB; Region: sufB; TIGR01980 881621007273 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 881621007274 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 881621007275 trimerization site [polypeptide binding]; other site 881621007276 active site 881621007277 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 881621007278 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 881621007279 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 881621007280 catalytic residue [active] 881621007281 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 881621007282 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 881621007283 FeS assembly ATPase SufC; Region: sufC; TIGR01978 881621007284 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 881621007285 Walker A/P-loop; other site 881621007286 ATP binding site [chemical binding]; other site 881621007287 Q-loop/lid; other site 881621007288 ABC transporter signature motif; other site 881621007289 Walker B; other site 881621007290 D-loop; other site 881621007291 H-loop/switch region; other site 881621007292 NMT1-like family; Region: NMT1_2; cl15260 881621007293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621007294 ABC-ATPase subunit interface; other site 881621007295 putative PBP binding loops; other site 881621007296 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 881621007297 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 881621007298 Walker A/P-loop; other site 881621007299 ATP binding site [chemical binding]; other site 881621007300 Q-loop/lid; other site 881621007301 ABC transporter signature motif; other site 881621007302 Walker B; other site 881621007303 D-loop; other site 881621007304 H-loop/switch region; other site 881621007305 NIL domain; Region: NIL; cl09633 881621007306 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 881621007307 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 881621007308 dimer interface [polypeptide binding]; other site 881621007309 phosphorylation site [posttranslational modification] 881621007310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621007311 ATP binding site [chemical binding]; other site 881621007312 Mg2+ binding site [ion binding]; other site 881621007313 G-X-G motif; other site 881621007314 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 881621007315 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 881621007316 active site 881621007317 phosphorylation site [posttranslational modification] 881621007318 intermolecular recognition site; other site 881621007319 dimerization interface [polypeptide binding]; other site 881621007320 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 881621007321 DNA binding site [nucleotide binding] 881621007322 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 881621007323 Cation efflux family; Region: Cation_efflux; cl00316 881621007324 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 881621007325 catalytic residues [active] 881621007326 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 881621007327 lipoyl attachment site [posttranslational modification]; other site 881621007328 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 881621007329 ArsC family; Region: ArsC; pfam03960 881621007330 putative ArsC-like catalytic residues; other site 881621007331 putative TRX-like catalytic residues [active] 881621007332 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 881621007333 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 881621007334 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 881621007335 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 881621007336 Walker A/P-loop; other site 881621007337 ATP binding site [chemical binding]; other site 881621007338 Q-loop/lid; other site 881621007339 ABC transporter signature motif; other site 881621007340 Walker B; other site 881621007341 D-loop; other site 881621007342 H-loop/switch region; other site 881621007343 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 881621007344 ABC-ATPase subunit interface; other site 881621007345 dimer interface [polypeptide binding]; other site 881621007346 putative PBP binding regions; other site 881621007347 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 881621007348 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 881621007349 intersubunit interface [polypeptide binding]; other site 881621007350 Predicted esterase [General function prediction only]; Region: COG0627 881621007351 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621007352 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 881621007353 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 881621007354 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621007355 catalytic residue [active] 881621007356 SdpI/YhfL protein family; Region: SdpI; pfam13630 881621007357 CAT RNA binding domain; Region: CAT_RBD; cl03904 881621007358 transcriptional antiterminator BglG; Provisional; Region: PRK09772 881621007359 PRD domain; Region: PRD; cl15445 881621007360 PRD domain; Region: PRD; cl15445 881621007361 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 881621007362 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 881621007363 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 881621007364 truncated, c-terminal part 881621007365 truncated, N-terminal part 881621007366 Predicted transcriptional regulator [Transcription]; Region: COG2378 881621007367 Helix-turn-helix domains; Region: HTH; cl00088 881621007368 WYL domain; Region: WYL; cl14852 881621007369 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 881621007370 putative active site [active] 881621007371 similar to glycosidase, C-terminal part 881621007372 similar to glycosidase, N-terminal part 881621007373 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621007374 leucine-rich repeat receptor-like protein kinase; Provisional; Region: PLN00113 881621007375 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 881621007376 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 881621007377 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 881621007378 active site 881621007379 catalytic site [active] 881621007380 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 881621007381 putative metal binding site [ion binding]; other site 881621007382 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621007383 non-specific DNA binding site [nucleotide binding]; other site 881621007384 salt bridge; other site 881621007385 sequence-specific DNA binding site [nucleotide binding]; other site 881621007386 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 881621007387 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 881621007388 SmpB-tmRNA interface; other site 881621007389 ribonuclease R; Region: RNase_R; TIGR02063 881621007390 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 881621007391 RNB domain; Region: RNB; pfam00773 881621007392 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 881621007393 RNA binding site [nucleotide binding]; other site 881621007394 Esterase/lipase [General function prediction only]; Region: COG1647 881621007395 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621007396 Esterase/lipase [General function prediction only]; Region: COG1647 881621007397 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621007398 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621007399 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621007400 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 881621007401 enolase; Provisional; Region: eno; PRK00077 881621007402 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 881621007403 dimer interface [polypeptide binding]; other site 881621007404 metal binding site [ion binding]; metal-binding site 881621007405 substrate binding pocket [chemical binding]; other site 881621007406 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 881621007407 Sulfatase; Region: Sulfatase; cl10460 881621007408 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 881621007409 substrate binding site [chemical binding]; other site 881621007410 dimer interface [polypeptide binding]; other site 881621007411 catalytic triad [active] 881621007412 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 881621007413 Phosphoglycerate kinase; Region: PGK; pfam00162 881621007414 substrate binding site [chemical binding]; other site 881621007415 hinge regions; other site 881621007416 ADP binding site [chemical binding]; other site 881621007417 catalytic site [active] 881621007418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621007419 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 881621007420 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 881621007421 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 881621007422 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 881621007423 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 881621007424 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 881621007425 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 881621007426 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 881621007427 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 881621007428 active site 881621007429 dimer interface [polypeptide binding]; other site 881621007430 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 881621007431 Protein export membrane protein; Region: SecD_SecF; cl14618 881621007432 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 881621007433 Helix-turn-helix domains; Region: HTH; cl00088 881621007434 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 881621007435 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621007436 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621007437 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621007438 LRR adjacent; Region: LRR_adjacent; pfam08191 881621007439 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 881621007440 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 881621007441 similar to internalin B and to Ami protein,partial 881621007442 similar to chitinase and chitin binding protein,C-terminal part 881621007443 similar to chitinase and chitin binding protein,N-terminal part 881621007444 Clp protease; Region: CLP_protease; pfam00574 881621007445 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 881621007446 oligomer interface [polypeptide binding]; other site 881621007447 active site residues [active] 881621007448 amino acid transporter; Region: 2A0306; TIGR00909 881621007449 Spore germination protein; Region: Spore_permease; cl15802 881621007450 Spore germination protein; Region: Spore_permease; cl15802 881621007451 similar to putative peptidoglycan linked protein (LPXTG motif), partial 881621007452 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 881621007453 active site 881621007454 FMN binding site [chemical binding]; other site 881621007455 substrate binding site [chemical binding]; other site 881621007456 homotetramer interface [polypeptide binding]; other site 881621007457 catalytic residue [active] 881621007458 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 881621007459 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 881621007460 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 881621007461 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 881621007462 phosphate binding site [ion binding]; other site 881621007463 putative substrate binding pocket [chemical binding]; other site 881621007464 dimer interface [polypeptide binding]; other site 881621007465 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 881621007466 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 881621007467 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 881621007468 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 881621007469 active site 881621007470 substrate binding site [chemical binding]; other site 881621007471 metal binding site [ion binding]; metal-binding site 881621007472 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 881621007473 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 881621007474 active site 881621007475 catalytic residues [active] 881621007476 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 881621007477 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 881621007478 NAD binding site [chemical binding]; other site 881621007479 homodimer interface [polypeptide binding]; other site 881621007480 active site 881621007481 substrate binding site [chemical binding]; other site 881621007482 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 881621007483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621007484 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 881621007485 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 881621007486 binding surface 881621007487 TPR motif; other site 881621007488 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 881621007489 binding surface 881621007490 TPR motif; other site 881621007491 similar to repressor protein 881621007492 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 881621007493 trimer interface [polypeptide binding]; other site 881621007494 active site 881621007495 substrate binding site [chemical binding]; other site 881621007496 CoA binding site [chemical binding]; other site 881621007497 pyrophosphatase PpaX; Provisional; Region: PRK13288 881621007498 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 881621007499 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621007500 motif II; other site 881621007501 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 881621007502 HPr kinase/phosphorylase; Provisional; Region: PRK05428 881621007503 DRTGG domain; Region: DRTGG; cl12147 881621007504 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 881621007505 Hpr binding site; other site 881621007506 active site 881621007507 homohexamer subunit interaction site [polypeptide binding]; other site 881621007508 Membrane protein of unknown function; Region: DUF360; cl00850 881621007509 PspC domain; Region: PspC; cl00864 881621007510 PspC domain; Region: PspC; cl00864 881621007511 Uncharacterized conserved protein [Function unknown]; Region: COG3595 881621007512 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 881621007513 Uncharacterized conserved protein [Function unknown]; Region: COG3595 881621007514 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 881621007515 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 881621007516 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 881621007517 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 881621007518 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 881621007519 excinuclease ABC subunit B; Provisional; Region: PRK05298 881621007520 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 881621007521 ATP binding site [chemical binding]; other site 881621007522 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621007523 nucleotide binding region [chemical binding]; other site 881621007524 ATP-binding site [chemical binding]; other site 881621007525 Ultra-violet resistance protein B; Region: UvrB; pfam12344 881621007526 UvrB/uvrC motif; Region: UVR; pfam02151 881621007527 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 881621007528 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 881621007529 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 881621007530 dimerization interface [polypeptide binding]; other site 881621007531 putative DNA binding site [nucleotide binding]; other site 881621007532 putative Zn2+ binding site [ion binding]; other site 881621007533 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 881621007534 PhoU domain; Region: PhoU; pfam01895 881621007535 PhoU domain; Region: PhoU; pfam01895 881621007536 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 881621007537 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 881621007538 Walker A/P-loop; other site 881621007539 ATP binding site [chemical binding]; other site 881621007540 Q-loop/lid; other site 881621007541 ABC transporter signature motif; other site 881621007542 Walker B; other site 881621007543 D-loop; other site 881621007544 H-loop/switch region; other site 881621007545 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 881621007546 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 881621007547 Walker A/P-loop; other site 881621007548 ATP binding site [chemical binding]; other site 881621007549 Q-loop/lid; other site 881621007550 ABC transporter signature motif; other site 881621007551 Walker B; other site 881621007552 D-loop; other site 881621007553 H-loop/switch region; other site 881621007554 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 881621007555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621007556 dimer interface [polypeptide binding]; other site 881621007557 conserved gate region; other site 881621007558 putative PBP binding loops; other site 881621007559 ABC-ATPase subunit interface; other site 881621007560 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 881621007561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621007562 dimer interface [polypeptide binding]; other site 881621007563 conserved gate region; other site 881621007564 putative PBP binding loops; other site 881621007565 ABC-ATPase subunit interface; other site 881621007566 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 881621007567 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 881621007568 sensory histidine kinase CreC; Provisional; Region: PRK11100 881621007569 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 881621007570 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 881621007571 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 881621007572 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 881621007573 dimer interface [polypeptide binding]; other site 881621007574 phosphorylation site [posttranslational modification] 881621007575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621007576 ATP binding site [chemical binding]; other site 881621007577 Mg2+ binding site [ion binding]; other site 881621007578 G-X-G motif; other site 881621007579 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 881621007580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 881621007581 active site 881621007582 phosphorylation site [posttranslational modification] 881621007583 intermolecular recognition site; other site 881621007584 dimerization interface [polypeptide binding]; other site 881621007585 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 881621007586 DNA binding site [nucleotide binding] 881621007587 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 881621007588 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 881621007589 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 881621007590 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 881621007591 putative active site [active] 881621007592 catalytic site [active] 881621007593 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 881621007594 putative active site [active] 881621007595 catalytic site [active] 881621007596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 881621007597 Peptidase family M23; Region: Peptidase_M23; pfam01551 881621007598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 881621007599 NlpC/P60 family; Region: NLPC_P60; cl11438 881621007600 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 881621007601 FtsX-like permease family; Region: FtsX; cl15850 881621007602 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 881621007603 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621007604 Walker A/P-loop; other site 881621007605 ATP binding site [chemical binding]; other site 881621007606 Q-loop/lid; other site 881621007607 ABC transporter signature motif; other site 881621007608 Walker B; other site 881621007609 D-loop; other site 881621007610 H-loop/switch region; other site 881621007611 Uncharacterized conserved protein [Function unknown]; Region: COG1284 881621007612 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 881621007613 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 881621007614 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 881621007615 peptide chain release factor 2; Validated; Region: prfB; PRK00578 881621007616 RF-1 domain; Region: RF-1; cl02875 881621007617 RF-1 domain; Region: RF-1; cl02875 881621007618 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 881621007619 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 881621007620 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621007621 nucleotide binding region [chemical binding]; other site 881621007622 ATP-binding site [chemical binding]; other site 881621007623 SEC-C motif; Region: SEC-C; pfam02810 881621007624 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 881621007625 30S subunit binding site; other site 881621007626 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 881621007627 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 881621007628 active site 881621007629 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 881621007630 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 881621007631 ATP binding site [chemical binding]; other site 881621007632 putative Mg++ binding site [ion binding]; other site 881621007633 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621007634 nucleotide binding region [chemical binding]; other site 881621007635 ATP-binding site [chemical binding]; other site 881621007636 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 881621007637 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 881621007638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 881621007639 active site 881621007640 phosphorylation site [posttranslational modification] 881621007641 intermolecular recognition site; other site 881621007642 dimerization interface [polypeptide binding]; other site 881621007643 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 881621007644 DNA binding residues [nucleotide binding] 881621007645 dimerization interface [polypeptide binding]; other site 881621007646 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 881621007647 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 881621007648 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 881621007649 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 881621007650 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 881621007651 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 881621007652 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 881621007653 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 881621007654 Mg++ binding site [ion binding]; other site 881621007655 putative catalytic motif [active] 881621007656 substrate binding site [chemical binding]; other site 881621007657 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 881621007658 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 881621007659 active site 881621007660 octamer interface [polypeptide binding]; other site 881621007661 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 881621007662 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 881621007663 putative peptidoglycan binding site; other site 881621007664 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 881621007665 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 881621007666 putative peptidoglycan binding site; other site 881621007667 3D domain; Region: 3D; cl01439 881621007668 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 881621007669 dimer interface [polypeptide binding]; other site 881621007670 ssDNA binding site [nucleotide binding]; other site 881621007671 tetramer (dimer of dimers) interface [polypeptide binding]; other site 881621007672 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 881621007673 rod shape-determining protein Mbl; Provisional; Region: PRK13928 881621007674 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 881621007675 ATP binding site [chemical binding]; other site 881621007676 Cell division protein FtsA; Region: FtsA; cl11496 881621007677 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 881621007678 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 881621007679 hinge; other site 881621007680 active site 881621007681 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 881621007682 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 881621007683 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 881621007684 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 881621007685 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 881621007686 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 881621007687 alpha subunit interaction interface [polypeptide binding]; other site 881621007688 Walker A motif; other site 881621007689 ATP binding site [chemical binding]; other site 881621007690 Walker B motif; other site 881621007691 inhibitor binding site; inhibition site 881621007692 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 881621007693 ATP synthase; Region: ATP-synt; cl00365 881621007694 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 881621007695 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 881621007696 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 881621007697 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 881621007698 beta subunit interaction interface [polypeptide binding]; other site 881621007699 Walker A motif; other site 881621007700 ATP binding site [chemical binding]; other site 881621007701 Walker B motif; other site 881621007702 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 881621007703 Plant ATP synthase F0; Region: YMF19; cl07975 881621007704 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 881621007705 Plant ATP synthase F0; Region: YMF19; cl07975 881621007706 ATP synthase subunit C; Region: ATP-synt_C; cl00466 881621007707 ATP synthase A chain; Region: ATP-synt_A; cl00413 881621007708 ATP synthase I chain; Region: ATP_synt_I; cl09170 881621007709 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 881621007710 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 881621007711 active site 881621007712 homodimer interface [polypeptide binding]; other site 881621007713 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 881621007714 active site 881621007715 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 881621007716 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 881621007717 dimer interface [polypeptide binding]; other site 881621007718 glycine-pyridoxal phosphate binding site [chemical binding]; other site 881621007719 active site 881621007720 folate binding site [chemical binding]; other site 881621007721 Low molecular weight phosphatase family; Region: LMWPc; cd00115 881621007722 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 881621007723 active site 881621007724 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 881621007725 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 881621007726 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 881621007727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 881621007728 S-adenosylmethionine binding site [chemical binding]; other site 881621007729 peptide chain release factor 1; Validated; Region: prfA; PRK00591 881621007730 RF-1 domain; Region: RF-1; cl02875 881621007731 RF-1 domain; Region: RF-1; cl02875 881621007732 thymidine kinase; Provisional; Region: PRK04296 881621007733 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621007734 ATP binding site [chemical binding]; other site 881621007735 Walker A motif; other site 881621007736 Walker B motif; other site 881621007737 homoserine kinase; Provisional; Region: PRK01212 881621007738 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 881621007739 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 881621007740 threonine synthase; Reviewed; Region: PRK06721 881621007741 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 881621007742 homodimer interface [polypeptide binding]; other site 881621007743 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621007744 catalytic residue [active] 881621007745 homoserine dehydrogenase; Provisional; Region: PRK06349 881621007746 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621007747 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 881621007748 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 881621007749 similar to transcription regulator MerR family,partial, C-terminal part 881621007750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621007751 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 881621007752 Cupin domain; Region: Cupin_2; cl09118 881621007753 Transcriptional regulator [Transcription]; Region: LysR; COG0583 881621007754 Helix-turn-helix domains; Region: HTH; cl00088 881621007755 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 881621007756 dimerization interface [polypeptide binding]; other site 881621007757 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 881621007758 GtrA-like protein; Region: GtrA; cl00971 881621007759 transcription termination factor Rho; Provisional; Region: rho; PRK09376 881621007760 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 881621007761 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 881621007762 RNA binding site [nucleotide binding]; other site 881621007763 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 881621007764 multimer interface [polypeptide binding]; other site 881621007765 Walker A motif; other site 881621007766 ATP binding site [chemical binding]; other site 881621007767 Walker B motif; other site 881621007768 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 881621007769 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 881621007770 hinge; other site 881621007771 active site 881621007772 Predicted integral membrane protein [Function unknown]; Region: COG0392 881621007773 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 881621007774 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 881621007775 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 881621007776 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 881621007777 putative ADP-binding pocket [chemical binding]; other site 881621007778 hypothetical protein; Provisional; Region: PRK08185 881621007779 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 881621007780 intersubunit interface [polypeptide binding]; other site 881621007781 active site 881621007782 zinc binding site [ion binding]; other site 881621007783 Na+ binding site [ion binding]; other site 881621007784 putative lipid kinase; Reviewed; Region: PRK13055 881621007785 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 881621007786 CTP synthetase; Validated; Region: pyrG; PRK05380 881621007787 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 881621007788 Catalytic site [active] 881621007789 active site 881621007790 UTP binding site [chemical binding]; other site 881621007791 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 881621007792 active site 881621007793 putative oxyanion hole; other site 881621007794 catalytic triad [active] 881621007795 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 881621007796 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 881621007797 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 881621007798 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 881621007799 active site 881621007800 HIGH motif; other site 881621007801 KMSK motif region; other site 881621007802 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 881621007803 tRNA binding surface [nucleotide binding]; other site 881621007804 anticodon binding site; other site 881621007805 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 881621007806 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 881621007807 active site 881621007808 putative substrate binding region [chemical binding]; other site 881621007809 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 881621007810 active site 1 [active] 881621007811 dimer interface [polypeptide binding]; other site 881621007812 hexamer interface [polypeptide binding]; other site 881621007813 active site 2 [active] 881621007814 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 881621007815 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 881621007816 Zn2+ binding site [ion binding]; other site 881621007817 Mg2+ binding site [ion binding]; other site 881621007818 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 881621007819 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 881621007820 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 881621007821 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 881621007822 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 881621007823 peptide binding site [polypeptide binding]; other site 881621007824 Predicted integral membrane protein [Function unknown]; Region: COG5658 881621007825 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 881621007826 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 881621007827 catalytic triad [active] 881621007828 metal binding site [ion binding]; metal-binding site 881621007829 conserved cis-peptide bond; other site 881621007830 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 881621007831 folate binding site [chemical binding]; other site 881621007832 NADP+ binding site [chemical binding]; other site 881621007833 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 881621007834 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 881621007835 putative NAD(P) binding site [chemical binding]; other site 881621007836 dimer interface [polypeptide binding]; other site 881621007837 Cation efflux family; Region: Cation_efflux; cl00316 881621007838 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 881621007839 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 881621007840 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621007841 active site 881621007842 motif I; other site 881621007843 motif II; other site 881621007844 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 881621007845 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621007846 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 881621007847 Helix-turn-helix domains; Region: HTH; cl00088 881621007848 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 881621007849 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 881621007850 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 881621007851 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 881621007852 catalytic loop [active] 881621007853 iron binding site [ion binding]; other site 881621007854 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 881621007855 4Fe-4S binding domain; Region: Fer4; cl02805 881621007856 4Fe-4S binding domain; Region: Fer4; cl02805 881621007857 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 881621007858 [4Fe-4S] binding site [ion binding]; other site 881621007859 molybdopterin cofactor binding site; other site 881621007860 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 881621007861 molybdopterin cofactor binding site; other site 881621007862 Uncharacterized conserved protein [Function unknown]; Region: COG1912 881621007863 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 881621007864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621007865 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621007866 putative substrate translocation pore; other site 881621007867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621007868 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 881621007869 Helix-turn-helix domains; Region: HTH; cl00088 881621007870 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 881621007871 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621007872 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 881621007873 Leucine-rich repeats; other site 881621007874 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621007875 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621007876 LRR adjacent; Region: LRR_adjacent; pfam08191 881621007877 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621007878 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 881621007879 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621007880 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621007881 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621007882 LRR adjacent; Region: LRR_adjacent; pfam08191 881621007883 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 881621007884 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 881621007885 Walker A motif; other site 881621007886 similar to putative endo-beta-N-acetylglucosaminidase, pseudogene, internal part 881621007887 similar to putative endo-beta-N-acetylglucosaminidase, N-terminal part 881621007888 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 881621007889 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 881621007890 23S rRNA interface [nucleotide binding]; other site 881621007891 L3 interface [polypeptide binding]; other site 881621007892 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 881621007893 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 881621007894 dimerization interface 3.5A [polypeptide binding]; other site 881621007895 active site 881621007896 Cobalt transport protein; Region: CbiQ; cl00463 881621007897 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 881621007898 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 881621007899 Walker A/P-loop; other site 881621007900 ATP binding site [chemical binding]; other site 881621007901 Q-loop/lid; other site 881621007902 ABC transporter signature motif; other site 881621007903 Walker B; other site 881621007904 D-loop; other site 881621007905 H-loop/switch region; other site 881621007906 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 881621007907 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 881621007908 Walker A/P-loop; other site 881621007909 ATP binding site [chemical binding]; other site 881621007910 Q-loop/lid; other site 881621007911 ABC transporter signature motif; other site 881621007912 Walker B; other site 881621007913 D-loop; other site 881621007914 H-loop/switch region; other site 881621007915 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 881621007916 MgtC family; Region: MgtC; pfam02308 881621007917 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 881621007918 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 881621007919 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 881621007920 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 881621007921 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 881621007922 alphaNTD - beta interaction site [polypeptide binding]; other site 881621007923 alphaNTD homodimer interface [polypeptide binding]; other site 881621007924 alphaNTD - beta' interaction site [polypeptide binding]; other site 881621007925 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 881621007926 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 881621007927 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 881621007928 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 881621007929 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 881621007930 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 881621007931 rRNA binding site [nucleotide binding]; other site 881621007932 predicted 30S ribosome binding site; other site 881621007933 adenylate kinase; Reviewed; Region: adk; PRK00279 881621007934 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 881621007935 AMP-binding site [chemical binding]; other site 881621007936 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 881621007937 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 881621007938 SecY translocase; Region: SecY; pfam00344 881621007939 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 881621007940 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 881621007941 23S rRNA binding site [nucleotide binding]; other site 881621007942 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 881621007943 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 881621007944 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 881621007945 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 881621007946 5S rRNA interface [nucleotide binding]; other site 881621007947 L27 interface [polypeptide binding]; other site 881621007948 23S rRNA interface [nucleotide binding]; other site 881621007949 L5 interface [polypeptide binding]; other site 881621007950 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 881621007951 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 881621007952 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 881621007953 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 881621007954 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 881621007955 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 881621007956 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 881621007957 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 881621007958 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 881621007959 KOW motif; Region: KOW; cl00354 881621007960 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 881621007961 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 881621007962 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 881621007963 23S rRNA interface [nucleotide binding]; other site 881621007964 putative translocon interaction site; other site 881621007965 signal recognition particle (SRP54) interaction site; other site 881621007966 L23 interface [polypeptide binding]; other site 881621007967 trigger factor interaction site; other site 881621007968 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 881621007969 23S rRNA interface [nucleotide binding]; other site 881621007970 5S rRNA interface [nucleotide binding]; other site 881621007971 putative antibiotic binding site [chemical binding]; other site 881621007972 L25 interface [polypeptide binding]; other site 881621007973 L27 interface [polypeptide binding]; other site 881621007974 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 881621007975 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 881621007976 G-X-X-G motif; other site 881621007977 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 881621007978 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 881621007979 putative translocon binding site; other site 881621007980 protein-rRNA interface [nucleotide binding]; other site 881621007981 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 881621007982 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 881621007983 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 881621007984 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 881621007985 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 881621007986 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 881621007987 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 881621007988 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 881621007989 Cobalt transport protein; Region: CbiQ; cl00463 881621007990 UbiA prenyltransferase family; Region: UbiA; cl00337 881621007991 ApbE family; Region: ApbE; cl00643 881621007992 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 881621007993 FMN-binding domain; Region: FMN_bind; cl01081 881621007994 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 881621007995 FMN-binding domain; Region: FMN_bind; cl01081 881621007996 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 881621007997 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 881621007998 DoxX; Region: DoxX; cl00976 881621007999 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 881621008000 trimer interface [polypeptide binding]; other site 881621008001 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973 881621008002 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 881621008003 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 881621008004 substrate binding pocket [chemical binding]; other site 881621008005 chain length determination region; other site 881621008006 substrate-Mg2+ binding site; other site 881621008007 catalytic residues [active] 881621008008 aspartate-rich region 1; other site 881621008009 active site lid residues [active] 881621008010 aspartate-rich region 2; other site 881621008011 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 881621008012 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 881621008013 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 881621008014 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 881621008015 hypothetical protein; Provisional; Region: PRK02947 881621008016 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 881621008017 putative active site [active] 881621008018 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 881621008019 Creatinine amidohydrolase; Region: Creatininase; cl00618 881621008020 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 881621008021 active site 881621008022 substrate binding pocket [chemical binding]; other site 881621008023 homodimer interaction site [polypeptide binding]; other site 881621008024 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 881621008025 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 881621008026 P-loop; other site 881621008027 active site 881621008028 phosphorylation site [posttranslational modification] 881621008029 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621008030 active site 881621008031 phosphorylation site [posttranslational modification] 881621008032 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 881621008033 Helix-turn-helix domains; Region: HTH; cl00088 881621008034 PRD domain; Region: PRD; cl15445 881621008035 PRD domain; Region: PRD; cl15445 881621008036 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 881621008037 P-loop; other site 881621008038 active site 881621008039 phosphorylation site [posttranslational modification] 881621008040 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621008041 active site 881621008042 phosphorylation site [posttranslational modification] 881621008043 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621008044 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 881621008045 Walker A/P-loop; other site 881621008046 ATP binding site [chemical binding]; other site 881621008047 Q-loop/lid; other site 881621008048 ABC transporter signature motif; other site 881621008049 Walker B; other site 881621008050 D-loop; other site 881621008051 H-loop/switch region; other site 881621008052 elongation factor Tu; Reviewed; Region: PRK00049 881621008053 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 881621008054 G1 box; other site 881621008055 GEF interaction site [polypeptide binding]; other site 881621008056 GTP/Mg2+ binding site [chemical binding]; other site 881621008057 Switch I region; other site 881621008058 G2 box; other site 881621008059 G3 box; other site 881621008060 Switch II region; other site 881621008061 G4 box; other site 881621008062 G5 box; other site 881621008063 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 881621008064 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 881621008065 Antibiotic Binding Site [chemical binding]; other site 881621008066 elongation factor G; Reviewed; Region: PRK00007 881621008067 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 881621008068 G1 box; other site 881621008069 putative GEF interaction site [polypeptide binding]; other site 881621008070 GTP/Mg2+ binding site [chemical binding]; other site 881621008071 Switch I region; other site 881621008072 G2 box; other site 881621008073 G3 box; other site 881621008074 Switch II region; other site 881621008075 G4 box; other site 881621008076 G5 box; other site 881621008077 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 881621008078 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 881621008079 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 881621008080 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 881621008081 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 881621008082 S17 interaction site [polypeptide binding]; other site 881621008083 S8 interaction site; other site 881621008084 16S rRNA interaction site [nucleotide binding]; other site 881621008085 streptomycin interaction site [chemical binding]; other site 881621008086 23S rRNA interaction site [nucleotide binding]; other site 881621008087 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 881621008088 similar to deoxyguanosinetriphosphate triphosphohydrolase, N-terminal part 881621008089 similar to deoxyguanosinetriphosphate triphosphohydrolase, C-terminal part 881621008090 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 881621008091 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 881621008092 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 881621008093 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621008094 Coenzyme A binding pocket [chemical binding]; other site 881621008095 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 881621008096 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 881621008097 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 881621008098 Gram positive anchor; Region: Gram_pos_anchor; cl15427 881621008099 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 881621008100 Substrate binding site [chemical binding]; other site 881621008101 Leucine rich repeat; Region: LRR_8; pfam13855 881621008102 Gram positive anchor; Region: Gram_pos_anchor; cl15427 881621008103 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 881621008104 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 881621008105 substrate binding site [chemical binding]; other site 881621008106 hexamer interface [polypeptide binding]; other site 881621008107 metal binding site [ion binding]; metal-binding site 881621008108 similar to transketolase, C-terminal part 881621008109 similar to transketolase, N-terminal part 881621008110 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 881621008111 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 881621008112 substrate binding site [chemical binding]; other site 881621008113 hexamer interface [polypeptide binding]; other site 881621008114 metal binding site [ion binding]; metal-binding site 881621008115 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 881621008116 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 881621008117 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 881621008118 putative NAD(P) binding site [chemical binding]; other site 881621008119 catalytic Zn binding site [ion binding]; other site 881621008120 structural Zn binding site [ion binding]; other site 881621008121 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 881621008122 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 881621008123 putative NAD(P) binding site [chemical binding]; other site 881621008124 catalytic Zn binding site [ion binding]; other site 881621008125 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 881621008126 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 881621008127 P-loop; other site 881621008128 active site 881621008129 phosphorylation site [posttranslational modification] 881621008130 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621008131 active site 881621008132 phosphorylation site [posttranslational modification] 881621008133 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 881621008134 PRD domain; Region: PRD; cl15445 881621008135 PRD domain; Region: PRD; cl15445 881621008136 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 881621008137 P-loop; other site 881621008138 active site 881621008139 phosphorylation site [posttranslational modification] 881621008140 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621008141 active site 881621008142 phosphorylation site [posttranslational modification] 881621008143 Predicted membrane protein [Function unknown]; Region: COG4905 881621008144 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 881621008145 Protein of unknown function (DUF419); Region: DUF419; cl15265 881621008146 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 881621008147 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 881621008148 active site 881621008149 metal binding site [ion binding]; metal-binding site 881621008150 Helix-turn-helix domain; Region: HTH_18; pfam12833 881621008151 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 881621008152 Ligand Binding Site [chemical binding]; other site 881621008153 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 881621008154 Similar to UV-damage repair protein, truncated, in frame stop codon 881621008155 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 881621008156 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 881621008157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 881621008158 active site 881621008159 phosphorylation site [posttranslational modification] 881621008160 intermolecular recognition site; other site 881621008161 dimerization interface [polypeptide binding]; other site 881621008162 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 881621008163 DNA binding site [nucleotide binding] 881621008164 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 881621008165 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 881621008166 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 881621008167 Ligand Binding Site [chemical binding]; other site 881621008168 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 881621008169 GAF domain; Region: GAF; cl15785 881621008170 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 881621008171 dimer interface [polypeptide binding]; other site 881621008172 phosphorylation site [posttranslational modification] 881621008173 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621008174 ATP binding site [chemical binding]; other site 881621008175 Mg2+ binding site [ion binding]; other site 881621008176 G-X-G motif; other site 881621008177 K+-transporting ATPase, c chain; Region: KdpC; cl00944 881621008178 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 881621008179 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 881621008180 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 881621008181 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 881621008182 active site 881621008183 P-loop; other site 881621008184 phosphorylation site [posttranslational modification] 881621008185 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 881621008186 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 881621008187 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 881621008188 methionine cluster; other site 881621008189 active site 881621008190 phosphorylation site [posttranslational modification] 881621008191 metal binding site [ion binding]; metal-binding site 881621008192 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 881621008193 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 881621008194 magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524 881621008195 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 881621008196 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 881621008197 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 881621008198 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 881621008199 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 881621008200 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 881621008201 Helix-turn-helix domains; Region: HTH; cl00088 881621008202 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 881621008203 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 881621008204 putative peptidoglycan binding site; other site 881621008205 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 881621008206 putative peptidoglycan binding site; other site 881621008207 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 881621008208 putative peptidoglycan binding site; other site 881621008209 Nitrogen regulatory protein P-II; Region: P-II; cl00412 881621008210 thymidylate kinase; Validated; Region: tmk; PRK00698 881621008211 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 881621008212 TMP-binding site; other site 881621008213 ATP-binding site [chemical binding]; other site 881621008214 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 881621008215 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 881621008216 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 881621008217 catalytic residue [active] 881621008218 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 881621008219 similar to unknown protein, truncated (pseudogene) 881621008220 similar to transposase, pseudogene 881621008221 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 881621008222 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 881621008223 DAK2 domain; Region: Dak2; cl03685 881621008224 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 881621008225 Similar to ABC transporter (ATP-binding protein),C-terminal part 881621008226 Similar to ABC transporter (ATP-binding protein),N-terminal part 881621008227 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 881621008228 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 881621008229 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 881621008230 putative active site [active] 881621008231 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 881621008232 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621008233 active site 881621008234 motif I; other site 881621008235 motif II; other site 881621008236 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 881621008237 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 881621008238 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 881621008239 putative trimer interface [polypeptide binding]; other site 881621008240 putative CoA binding site [chemical binding]; other site 881621008241 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 881621008242 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621008243 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621008244 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621008245 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 881621008246 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 881621008247 inhibitor-cofactor binding pocket; inhibition site 881621008248 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621008249 catalytic residue [active] 881621008250 Bacterial sugar transferase; Region: Bac_transf; cl00939 881621008251 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 881621008252 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 881621008253 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 881621008254 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 881621008255 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 881621008256 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 881621008257 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621008258 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 881621008259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621008260 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 881621008261 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 881621008262 NAD(P) binding site [chemical binding]; other site 881621008263 homodimer interface [polypeptide binding]; other site 881621008264 substrate binding site [chemical binding]; other site 881621008265 active site 881621008266 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 881621008267 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621008268 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 881621008269 Chain length determinant protein; Region: Wzz; cl15801 881621008270 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 881621008271 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 881621008272 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621008273 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 881621008274 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 881621008275 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 881621008276 nudix motif; other site 881621008277 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 881621008278 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 881621008279 active site 881621008280 catalytic tetrad [active] 881621008281 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 881621008282 active site 881621008283 methionine cluster; other site 881621008284 phosphorylation site [posttranslational modification] 881621008285 metal binding site [ion binding]; metal-binding site 881621008286 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 881621008287 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621008288 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 881621008289 active site 881621008290 motif I; other site 881621008291 motif II; other site 881621008292 similar to glycosyl hydrolase, internal part 881621008293 similar to glycosyl hydrolase, N-terminal part 881621008294 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 881621008295 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 881621008296 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 881621008297 active site 881621008298 P-loop; other site 881621008299 phosphorylation site [posttranslational modification] 881621008300 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 881621008301 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621008302 DNA-binding site [nucleotide binding]; DNA binding site 881621008303 UTRA domain; Region: UTRA; cl01230 881621008304 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 881621008305 recombination protein RecR; Reviewed; Region: recR; PRK00076 881621008306 RecR protein; Region: RecR; pfam02132 881621008307 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 881621008308 putative active site [active] 881621008309 putative metal-binding site [ion binding]; other site 881621008310 tetramer interface [polypeptide binding]; other site 881621008311 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 881621008312 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 881621008313 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621008314 Walker A motif; other site 881621008315 ATP binding site [chemical binding]; other site 881621008316 Walker B motif; other site 881621008317 arginine finger; other site 881621008318 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 881621008319 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 881621008320 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 881621008321 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 881621008322 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 881621008323 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 881621008324 N- and C-terminal domain interface [polypeptide binding]; other site 881621008325 putative active site [active] 881621008326 catalytic site [active] 881621008327 metal binding site [ion binding]; metal-binding site 881621008328 carbohydrate binding site [chemical binding]; other site 881621008329 ATP binding site [chemical binding]; other site 881621008330 SH3-like domain; Region: SH3_8; pfam13457 881621008331 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 881621008332 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 881621008333 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 881621008334 The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd...; Region: ABCC_cytochrome_bd; cd03247 881621008335 Walker A/P-loop; other site 881621008336 ATP binding site [chemical binding]; other site 881621008337 Q-loop/lid; other site 881621008338 ABC transporter signature motif; other site 881621008339 Walker B; other site 881621008340 D-loop; other site 881621008341 H-loop/switch region; other site 881621008342 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 881621008343 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 881621008344 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621008345 Walker A/P-loop; other site 881621008346 ATP binding site [chemical binding]; other site 881621008347 Q-loop/lid; other site 881621008348 ABC transporter signature motif; other site 881621008349 Walker B; other site 881621008350 D-loop; other site 881621008351 H-loop/switch region; other site 881621008352 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 881621008353 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 881621008354 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 881621008355 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 881621008356 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 881621008357 nucleoside/Zn binding site; other site 881621008358 dimer interface [polypeptide binding]; other site 881621008359 catalytic motif [active] 881621008360 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 881621008361 AMP-binding enzyme; Region: AMP-binding; cl15778 881621008362 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 881621008363 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 881621008364 active site 881621008365 trimer interface [polypeptide binding]; other site 881621008366 allosteric site; other site 881621008367 active site lid [active] 881621008368 hexamer (dimer of trimers) interface [polypeptide binding]; other site 881621008369 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 881621008370 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 881621008371 DNA binding residues [nucleotide binding] 881621008372 drug binding residues [chemical binding]; other site 881621008373 dimer interface [polypeptide binding]; other site 881621008374 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 881621008375 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 881621008376 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 881621008377 dimer interface [polypeptide binding]; other site 881621008378 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 881621008379 MatE; Region: MatE; cl10513 881621008380 MatE; Region: MatE; cl10513 881621008381 Helix-turn-helix domains; Region: HTH; cl00088 881621008382 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 881621008383 Helix-turn-helix domains; Region: HTH; cl00088 881621008384 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 881621008385 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 881621008386 DNA binding residues [nucleotide binding] 881621008387 putative dimer interface [polypeptide binding]; other site 881621008388 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 881621008389 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621008390 motif II; other site 881621008391 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621008392 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621008393 DNA binding site [nucleotide binding] 881621008394 domain linker motif; other site 881621008395 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 881621008396 putative dimerization interface [polypeptide binding]; other site 881621008397 putative ligand binding site [chemical binding]; other site 881621008398 NAD-dependent deacetylase; Provisional; Region: PRK00481 881621008399 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 881621008400 NAD+ binding site [chemical binding]; other site 881621008401 substrate binding site [chemical binding]; other site 881621008402 putative Zn binding site [ion binding]; other site 881621008403 TfoX N-terminal domain; Region: TfoX_N; cl01167 881621008404 drug efflux system protein MdtG; Provisional; Region: PRK09874 881621008405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621008406 putative substrate translocation pore; other site 881621008407 Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of...; Region: SH3; cl15350 881621008408 Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of...; Region: SH3; cl15350 881621008409 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 881621008410 active site 881621008411 intersubunit interactions; other site 881621008412 catalytic residue [active] 881621008413 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 881621008414 Helix-turn-helix domains; Region: HTH; cl00088 881621008415 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 881621008416 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 881621008417 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621008418 Walker A/P-loop; other site 881621008419 ATP binding site [chemical binding]; other site 881621008420 Q-loop/lid; other site 881621008421 ABC transporter signature motif; other site 881621008422 Walker B; other site 881621008423 D-loop; other site 881621008424 H-loop/switch region; other site 881621008425 TfoX N-terminal domain; Region: TfoX_N; cl01167 881621008426 seryl-tRNA synthetase; Provisional; Region: PRK05431 881621008427 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 881621008428 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 881621008429 dimer interface [polypeptide binding]; other site 881621008430 active site 881621008431 motif 1; other site 881621008432 motif 2; other site 881621008433 motif 3; other site 881621008434 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 881621008435 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 881621008436 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 881621008437 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 881621008438 glutamine binding [chemical binding]; other site 881621008439 catalytic triad [active] 881621008440 aminodeoxychorismate synthase; Provisional; Region: PRK07508 881621008441 chorismate binding enzyme; Region: Chorismate_bind; cl10555 881621008442 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 881621008443 substrate-cofactor binding pocket; other site 881621008444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621008445 catalytic residue [active] 881621008446 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 881621008447 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 881621008448 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621008449 Walker A/P-loop; other site 881621008450 ATP binding site [chemical binding]; other site 881621008451 Q-loop/lid; other site 881621008452 ABC transporter signature motif; other site 881621008453 Walker B; other site 881621008454 D-loop; other site 881621008455 H-loop/switch region; other site 881621008456 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 881621008457 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 881621008458 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 881621008459 Walker A/P-loop; other site 881621008460 ATP binding site [chemical binding]; other site 881621008461 Q-loop/lid; other site 881621008462 ABC transporter signature motif; other site 881621008463 Walker B; other site 881621008464 D-loop; other site 881621008465 H-loop/switch region; other site 881621008466 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 881621008467 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 881621008468 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 881621008469 Predicted acyl esterases [General function prediction only]; Region: COG2936 881621008470 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 881621008471 DNA topoisomerase III; Provisional; Region: PRK07726 881621008472 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 881621008473 active site 881621008474 putative interdomain interaction site [polypeptide binding]; other site 881621008475 putative metal-binding site [ion binding]; other site 881621008476 putative nucleotide binding site [chemical binding]; other site 881621008477 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 881621008478 domain I; other site 881621008479 DNA binding groove [nucleotide binding] 881621008480 phosphate binding site [ion binding]; other site 881621008481 domain II; other site 881621008482 domain III; other site 881621008483 nucleotide binding site [chemical binding]; other site 881621008484 catalytic site [active] 881621008485 domain IV; other site 881621008486 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 881621008487 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 881621008488 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 881621008489 ATP binding site [chemical binding]; other site 881621008490 putative Mg++ binding site [ion binding]; other site 881621008491 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621008492 nucleotide binding region [chemical binding]; other site 881621008493 ATP-binding site [chemical binding]; other site 881621008494 RQC domain; Region: RQC; cl09632 881621008495 HRDC domain; Region: HRDC; cl02578 881621008496 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 881621008497 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 881621008498 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 881621008499 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 881621008500 active site 881621008501 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 881621008502 putative ADP-ribose binding site [chemical binding]; other site 881621008503 putative active site [active] 881621008504 Similar to ABC transporter (ATP-binding protein),C-terminal part 881621008505 Similar to ABC transporter (ATP-binding protein),N-terminal part 881621008506 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 881621008507 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 881621008508 active site 881621008509 P-loop; other site 881621008510 phosphorylation site [posttranslational modification] 881621008511 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 881621008512 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 881621008513 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 881621008514 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 881621008515 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 881621008516 methionine cluster; other site 881621008517 active site 881621008518 phosphorylation site [posttranslational modification] 881621008519 metal binding site [ion binding]; metal-binding site 881621008520 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 881621008521 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 881621008522 similar to beta-glucosidase, partial 881621008523 Similar to beta-glucoside-specific PTS system enzyme IIABC, C-terminal part 881621008524 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 881621008525 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 881621008526 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 881621008527 putative active site [active] 881621008528 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 881621008529 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 881621008530 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 881621008531 Walker A/P-loop; other site 881621008532 ATP binding site [chemical binding]; other site 881621008533 Q-loop/lid; other site 881621008534 ABC transporter signature motif; other site 881621008535 Walker B; other site 881621008536 D-loop; other site 881621008537 H-loop/switch region; other site 881621008538 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl15791 881621008539 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 881621008540 ATP-grasp domain; Region: ATP-grasp_4; cl03087 881621008541 GTP-binding protein YchF; Reviewed; Region: PRK09601 881621008542 YchF GTPase; Region: YchF; cd01900 881621008543 G1 box; other site 881621008544 GTP/Mg2+ binding site [chemical binding]; other site 881621008545 Switch I region; other site 881621008546 G2 box; other site 881621008547 Switch II region; other site 881621008548 G3 box; other site 881621008549 G4 box; other site 881621008550 G5 box; other site 881621008551 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 881621008552 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 881621008553 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 881621008554 tetramer interface [polypeptide binding]; other site 881621008555 heme binding pocket [chemical binding]; other site 881621008556 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 881621008557 ParB-like partition proteins; Region: parB_part; TIGR00180 881621008558 ParB-like nuclease domain; Region: ParBc; cl02129 881621008559 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 881621008560 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 881621008561 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 881621008562 P-loop; other site 881621008563 Magnesium ion binding site [ion binding]; other site 881621008564 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 881621008565 Magnesium ion binding site [ion binding]; other site 881621008566 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 881621008567 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 881621008568 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 881621008569 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 881621008570 active site 881621008571 purine riboside binding site [chemical binding]; other site 881621008572 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 881621008573 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 881621008574 substrate binding site [chemical binding]; other site 881621008575 dimer interface [polypeptide binding]; other site 881621008576 ATP binding site [chemical binding]; other site 881621008577 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 881621008578 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 881621008579 Walker A/P-loop; other site 881621008580 ATP binding site [chemical binding]; other site 881621008581 Q-loop/lid; other site 881621008582 ABC transporter signature motif; other site 881621008583 Walker B; other site 881621008584 D-loop; other site 881621008585 H-loop/switch region; other site 881621008586 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 881621008587 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 881621008588 Walker A/P-loop; other site 881621008589 ATP binding site [chemical binding]; other site 881621008590 Q-loop/lid; other site 881621008591 ABC transporter signature motif; other site 881621008592 Walker B; other site 881621008593 D-loop; other site 881621008594 H-loop/switch region; other site 881621008595 Cobalt transport protein; Region: CbiQ; cl00463 881621008596 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 881621008597 active site 881621008598 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621008599 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621008600 DNA binding site [nucleotide binding] 881621008601 domain linker motif; other site 881621008602 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 881621008603 dimerization interface [polypeptide binding]; other site 881621008604 ligand binding site [chemical binding]; other site 881621008605 ParB-like partition proteins; Region: parB_part; TIGR00180 881621008606 ParB-like nuclease domain; Region: ParBc; cl02129 881621008607 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 881621008608 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 881621008609 putative active site cavity [active] 881621008610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 881621008611 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 881621008612 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 881621008613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621008614 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 881621008615 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 881621008616 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 881621008617 trmE is a tRNA modification GTPase; Region: trmE; cd04164 881621008618 G1 box; other site 881621008619 GTP/Mg2+ binding site [chemical binding]; other site 881621008620 Switch I region; other site 881621008621 G2 box; other site 881621008622 Switch II region; other site 881621008623 G3 box; other site 881621008624 G4 box; other site 881621008625 G5 box; other site 881621008626 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 881621008627 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 881621008628 Gram positive anchor; Region: Gram_pos_anchor; cl15427 881621008629 Protein of unknown function (DUF1015); Region: DUF1015; cl01715 881621008630 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621008631 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 881621008632 L-serine binding site [chemical binding]; other site 881621008633 ACT domain interface; other site 881621008634 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 881621008635 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 881621008636 homodimer interface [polypeptide binding]; other site 881621008637 substrate-cofactor binding pocket; other site 881621008638 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621008639 catalytic residue [active] 881621008640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621008641 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621008642 putative substrate translocation pore; other site 881621008643 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 881621008644 Helix-turn-helix domains; Region: HTH; cl00088 881621008645 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 881621008646 dimer interface [polypeptide binding]; other site 881621008647 FMN binding site [chemical binding]; other site 881621008648 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 881621008649 catalytic residues [active] 881621008650 beta-phosphoglucomutase; Region: bPGM; TIGR01990 881621008651 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621008652 motif II; other site 881621008653 Glycerate kinase family; Region: Gly_kinase; cl00841 881621008654 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 881621008655 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 881621008656 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 881621008657 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 881621008658 similar to oxidoreductases, C-terminal part 881621008659 similar to oxidoreductases, N-terminal part 881621008660 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 881621008661 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 881621008662 Metal-binding active site; metal-binding site 881621008663 AP (apurinic/apyrimidinic) site pocket; other site 881621008664 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 881621008665 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 881621008666 putative NAD(P) binding site [chemical binding]; other site 881621008667 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 881621008668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621008669 dimer interface [polypeptide binding]; other site 881621008670 conserved gate region; other site 881621008671 putative PBP binding loops; other site 881621008672 ABC-ATPase subunit interface; other site 881621008673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621008674 dimer interface [polypeptide binding]; other site 881621008675 conserved gate region; other site 881621008676 putative PBP binding loops; other site 881621008677 ABC-ATPase subunit interface; other site 881621008678 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 881621008679 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 881621008680 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 881621008681 sucrose phosphorylase; Provisional; Region: PRK13840 881621008682 active site 881621008683 homodimer interface [polypeptide binding]; other site 881621008684 catalytic site [active] 881621008685 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621008686 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621008687 DNA binding site [nucleotide binding] 881621008688 domain linker motif; other site 881621008689 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 881621008690 putative dimerization interface [polypeptide binding]; other site 881621008691 putative ligand binding site [chemical binding]; other site 881621008692 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 881621008693 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 881621008694 Gram positive anchor; Region: Gram_pos_anchor; cl15427 881621008695 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 881621008696 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 881621008697 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 881621008698 G-X-X-G motif; other site 881621008699 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 881621008700 RxxxH motif; other site 881621008701 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 881621008702 Ribonuclease P; Region: Ribonuclease_P; cl00457 881621008703 Ribosomal protein L34; Region: Ribosomal_L34; cl00370