-- dump date 20111121_012903 -- class Genbank::misc_feature -- table misc_feature_note -- id note 637381000001 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 637381000002 Ribonuclease P; Region: Ribonuclease_P; cl00457 637381000003 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 637381000004 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 637381000005 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 637381000006 G-X-X-G motif; other site 637381000007 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 637381000008 RxxxH motif; other site 637381000009 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 637381000010 Cupin domain; Region: Cupin_2; cl09118 637381000011 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637381000012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637381000013 putative substrate translocation pore; other site 637381000014 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637381000015 L-rhamnulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 637381000016 N- and C-terminal domain interface [polypeptide binding]; other site 637381000017 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 637381000018 active site 637381000019 catalytic site [active] 637381000020 metal binding site [ion binding]; metal-binding site 637381000021 ATP binding site [chemical binding]; other site 637381000022 carbohydrate binding site [chemical binding]; other site 637381000023 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 637381000024 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 637381000025 intersubunit interface [polypeptide binding]; other site 637381000026 active site 637381000027 Zn2+ binding site [ion binding]; other site 637381000028 Domain of unknown function (DUF718); Region: DUF718; cl01281 637381000029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637381000030 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637381000031 putative substrate translocation pore; other site 637381000032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637381000033 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637381000034 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637381000035 Domain of Unknown Function with PDB structure; Region: DUF3857; pfam12969 637381000036 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279 637381000037 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637381000038 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637381000039 DNA binding site [nucleotide binding] 637381000040 domain linker motif; other site 637381000041 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 637381000042 putative dimerization interface [polypeptide binding]; other site 637381000043 putative ligand binding site [chemical binding]; other site 637381000044 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 637381000045 sucrose phosphorylase; Provisional; Region: PRK13840 637381000046 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 637381000047 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637381000048 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381000049 dimer interface [polypeptide binding]; other site 637381000050 conserved gate region; other site 637381000051 putative PBP binding loops; other site 637381000052 ABC-ATPase subunit interface; other site 637381000053 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 637381000054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381000055 dimer interface [polypeptide binding]; other site 637381000056 conserved gate region; other site 637381000057 putative PBP binding loops; other site 637381000058 ABC-ATPase subunit interface; other site 637381000059 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 637381000060 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 637381000061 putative NAD(P) binding site [chemical binding]; other site 637381000062 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 637381000063 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 637381000064 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381000065 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 637381000066 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 637381000067 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 637381000068 Glycerate kinase family; Region: Gly_kinase; cl00841 637381000069 beta-phosphoglucomutase; Region: bPGM; TIGR01990 637381000070 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637381000071 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637381000072 motif II; other site 637381000073 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 637381000074 catalytic residues [active] 637381000075 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 637381000076 dimer interface [polypeptide binding]; other site 637381000077 FMN binding site [chemical binding]; other site 637381000078 Transcriptional regulators [Transcription]; Region: MarR; COG1846 637381000079 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381000080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637381000081 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637381000082 putative substrate translocation pore; other site 637381000083 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 637381000084 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active...; Region: PSAT_like; cd00611 637381000085 homodimer interface [polypeptide binding]; other site 637381000086 substrate-cofactor binding pocket; other site 637381000087 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637381000088 catalytic residue [active] 637381000089 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 637381000090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381000091 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 637381000092 L-serine binding site [chemical binding]; other site 637381000093 ACT domain interface; other site 637381000094 Protein of unknown function (DUF1015); Region: DUF1015; cl01715 637381000095 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 637381000096 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309 637381000097 Leucine-rich repeats; other site 637381000098 Substrate binding site [chemical binding]; other site 637381000099 MucBP domain; Region: MucBP; pfam06458 637381000100 MucBP domain; Region: MucBP; pfam06458 637381000101 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 637381000102 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637381000103 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637381000104 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; cl10042 637381000105 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 637381000106 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 637381000107 metal binding site [ion binding]; metal-binding site 637381000108 dimer interface [polypeptide binding]; other site 637381000109 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 637381000110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 637381000111 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 637381000112 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 637381000113 metal binding site [ion binding]; metal-binding site 637381000114 dimer interface [polypeptide binding]; other site 637381000115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637381000116 D-galactonate transporter; Region: 2A0114; TIGR00893 637381000117 putative substrate translocation pore; other site 637381000118 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 637381000119 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 637381000120 NADP binding site [chemical binding]; other site 637381000121 homodimer interface [polypeptide binding]; other site 637381000122 active site 637381000123 substrate binding site [chemical binding]; other site 637381000124 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637381000125 Beta-lactamase; Region: Beta-lactamase; cl01009 637381000126 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 637381000127 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 637381000128 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 637381000129 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 637381000130 G1 box; other site 637381000131 GTP/Mg2+ binding site [chemical binding]; other site 637381000132 Switch I region; other site 637381000133 G2 box; other site 637381000134 Switch II region; other site 637381000135 G3 box; other site 637381000136 G4 box; other site 637381000137 G5 box; other site 637381000138 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 637381000139 Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445 637381000140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381000141 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 637381000142 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 637381000143 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 637381000144 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 637381000145 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 637381000146 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 637381000147 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 637381000148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637381000149 S-adenosylmethionine binding site [chemical binding]; other site 637381000150 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family...; Region: NanE; cd04729 637381000151 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 637381000152 putative active site cavity [active] 637381000153 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 637381000154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381000155 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 637381000156 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 637381000157 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637381000158 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_mannitol; cd05567 637381000159 active site 637381000160 P-loop; other site 637381000161 phosphorylation site [posttranslational modification] 637381000162 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 637381000163 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637381000164 motif II; other site 637381000165 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637381000166 active site 637381000167 phosphorylation site [posttranslational modification] 637381000168 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 637381000169 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 637381000170 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 637381000171 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 637381000172 putative active site [active] 637381000173 ParB-like partition proteins; Region: parB_part; TIGR00180 637381000174 ParB-like nuclease domain; Region: ParBc; cl02129 637381000175 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 637381000176 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 637381000177 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 637381000178 P-loop; other site 637381000179 Magnesium ion binding site [ion binding]; other site 637381000180 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 637381000181 Magnesium ion binding site [ion binding]; other site 637381000182 ParB-like partition proteins; Region: parB_part; TIGR00180 637381000183 ParB-like nuclease domain; Region: ParBc; cl02129 637381000184 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 637381000185 transcriptional antiterminator BglG; Provisional; Region: PRK09772 637381000186 CAT RNA binding domain; Region: CAT_RBD; cl03904 637381000187 PRD domain; Region: PRD; pfam00874 637381000188 PRD domain; Region: PRD; pfam00874 637381000189 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 637381000190 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 637381000191 active site turn [active] 637381000192 phosphorylation site [posttranslational modification] 637381000193 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637381000194 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 637381000195 HPr interaction site; other site 637381000196 glycerol kinase (GK) interaction site [polypeptide binding]; other site 637381000197 active site 637381000198 phosphorylation site [posttranslational modification] 637381000199 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 637381000200 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 637381000201 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 637381000202 tetramer interface [polypeptide binding]; other site 637381000203 heme binding pocket [chemical binding]; other site 637381000204 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 637381000205 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381000206 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381000207 PRD domain; Region: PRD; pfam00874 637381000208 PRD domain; Region: PRD; pfam00874 637381000209 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 637381000210 P-loop; other site 637381000211 active site 637381000212 phosphorylation site [posttranslational modification] 637381000213 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637381000214 active site 637381000215 phosphorylation site [posttranslational modification] 637381000216 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637381000217 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564 637381000218 active site 637381000219 P-loop; other site 637381000220 phosphorylation site [posttranslational modification] 637381000221 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 637381000222 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 637381000223 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 637381000224 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 637381000225 methionine cluster; other site 637381000226 active site 637381000227 phosphorylation site [posttranslational modification] 637381000228 metal binding site [ion binding]; metal-binding site 637381000229 GTP-binding protein YchF; Reviewed; Region: PRK09601 637381000230 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 637381000231 G1 box; other site 637381000232 GTP/Mg2+ binding site [chemical binding]; other site 637381000233 Switch I region; other site 637381000234 G2 box; other site 637381000235 Switch II region; other site 637381000236 G3 box; other site 637381000237 G4 box; other site 637381000238 G5 box; other site 637381000239 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 637381000240 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 637381000241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637381000242 putative substrate translocation pore; other site 637381000243 transcriptional antiterminator BglG; Provisional; Region: PRK09772 637381000244 CAT RNA binding domain; Region: CAT_RBD; cl03904 637381000245 PRD domain; Region: PRD; pfam00874 637381000246 PRD domain; Region: PRD; pfam00874 637381000247 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 637381000248 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 637381000249 active site turn [active] 637381000250 phosphorylation site [posttranslational modification] 637381000251 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637381000252 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cd00210 637381000253 HPr interaction site; other site 637381000254 glycerol kinase (GK) interaction site [polypeptide binding]; other site 637381000255 active site 637381000256 phosphorylation site [posttranslational modification] 637381000257 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 637381000258 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 637381000259 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl01099 637381000260 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 637381000261 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 637381000262 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 637381000263 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 637381000264 Walker A/P-loop; other site 637381000265 ATP binding site [chemical binding]; other site 637381000266 Q-loop/lid; other site 637381000267 ABC transporter signature motif; other site 637381000268 Walker B; other site 637381000269 D-loop; other site 637381000270 H-loop/switch region; other site 637381000271 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 637381000272 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 637381000273 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 637381000274 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 637381000275 putative active site [active] 637381000276 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 637381000277 methionine cluster; other site 637381000278 active site 637381000279 phosphorylation site [posttranslational modification] 637381000280 metal binding site [ion binding]; metal-binding site 637381000281 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 637381000282 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 637381000283 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637381000284 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564 637381000285 active site 637381000286 P-loop; other site 637381000287 phosphorylation site [posttranslational modification] 637381000288 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 637381000289 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 637381000290 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 637381000291 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 637381000292 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 637381000293 ABC transporter; Region: ABC_tran_2; pfam12848 637381000294 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 637381000295 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 637381000296 putative ADP-ribose binding site [chemical binding]; other site 637381000297 putative active site [active] 637381000298 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 637381000299 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 637381000300 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 637381000301 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 637381000302 active site 637381000303 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 637381000304 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637381000305 ATP binding site [chemical binding]; other site 637381000306 putative Mg++ binding site [ion binding]; other site 637381000307 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637381000308 nucleotide binding region [chemical binding]; other site 637381000309 ATP-binding site [chemical binding]; other site 637381000310 RQC domain; Region: RQC; cl09632 637381000311 HRDC domain; Region: HRDC; cl02578 637381000312 DNA topoisomerase III; Provisional; Region: PRK07726 637381000313 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by:...; Region: TOPRIM_TopoIA_TopoIII; cd03362 637381000314 active site 637381000315 putative interdomain interaction site [polypeptide binding]; other site 637381000316 putative metal-binding site [ion binding]; other site 637381000317 putative nucleotide binding site [chemical binding]; other site 637381000318 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 637381000319 domain I; other site 637381000320 DNA binding groove [nucleotide binding] 637381000321 phosphate binding site [ion binding]; other site 637381000322 domain II; other site 637381000323 domain III; other site 637381000324 nucleotide binding site [chemical binding]; other site 637381000325 catalytic site [active] 637381000326 domain IV; other site 637381000327 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 637381000328 Predicted acyl esterases [General function prediction only]; Region: COG2936 637381000329 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 637381000330 Beta-lactamase; Region: Beta-lactamase; cl01009 637381000331 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 637381000332 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 637381000333 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637381000334 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 637381000335 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381000336 Walker A/P-loop; other site 637381000337 ATP binding site [chemical binding]; other site 637381000338 Q-loop/lid; other site 637381000339 ABC transporter signature motif; other site 637381000340 Walker B; other site 637381000341 D-loop; other site 637381000342 H-loop/switch region; other site 637381000343 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637381000344 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 637381000345 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381000346 Walker A/P-loop; other site 637381000347 ATP binding site [chemical binding]; other site 637381000348 Q-loop/lid; other site 637381000349 ABC transporter signature motif; other site 637381000350 Walker B; other site 637381000351 D-loop; other site 637381000352 H-loop/switch region; other site 637381000353 aminodeoxychorismate synthase; Provisional; Region: PRK07508 637381000354 chorismate binding enzyme; Region: Chorismate_bind; cl10555 637381000355 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 637381000356 substrate-cofactor binding pocket; other site 637381000357 homodimer interface [polypeptide binding]; other site 637381000358 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637381000359 catalytic residue [active] 637381000360 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 637381000361 Glutamine amidotransferase class-I; Region: GATase; pfam00117 637381000362 glutamine binding [chemical binding]; other site 637381000363 catalytic triad [active] 637381000364 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 637381000365 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 637381000366 seryl-tRNA synthetase; Provisional; Region: PRK05431 637381000367 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 637381000368 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 637381000369 dimer interface [polypeptide binding]; other site 637381000370 active site 637381000371 motif 1; other site 637381000372 motif 2; other site 637381000373 motif 3; other site 637381000374 TfoX N-terminal domain; Region: TfoX_N; cl01167 637381000375 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637381000376 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 637381000377 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381000378 Walker A/P-loop; other site 637381000379 ATP binding site [chemical binding]; other site 637381000380 Q-loop/lid; other site 637381000381 ABC transporter signature motif; other site 637381000382 Walker B; other site 637381000383 D-loop; other site 637381000384 H-loop/switch region; other site 637381000385 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 637381000386 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 637381000387 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 637381000388 active site 637381000389 intersubunit interactions; other site 637381000390 catalytic residue [active] 637381000391 Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization...; Region: SH3; cl15350 637381000392 Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization...; Region: SH3; cl15350 637381000393 drug efflux system protein MdtG; Provisional; Region: PRK09874 637381000394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637381000395 putative substrate translocation pore; other site 637381000396 TfoX N-terminal domain; Region: TfoX_N; cl01167 637381000397 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 637381000398 NAD+ binding site [chemical binding]; other site 637381000399 substrate binding site [chemical binding]; other site 637381000400 putative Zn binding site [ion binding]; other site 637381000401 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 637381000402 Domain of unknown function DUF21; Region: DUF21; pfam01595 637381000403 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 637381000404 Transporter associated domain; Region: CorC_HlyC; cl08393 637381000405 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637381000406 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637381000407 DNA binding site [nucleotide binding] 637381000408 domain linker motif; other site 637381000409 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 637381000410 putative dimerization interface [polypeptide binding]; other site 637381000411 putative ligand binding site [chemical binding]; other site 637381000412 Glycerate kinase family; Region: Gly_kinase; cl00841 637381000413 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 637381000414 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 637381000415 alpha-mannosidase; Provisional; Region: PRK09819 637381000416 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 637381000417 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 637381000418 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 637381000419 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637381000420 active site 637381000421 phosphorylation site [posttranslational modification] 637381000422 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 637381000423 P-loop; other site 637381000424 active site 637381000425 phosphorylation site [posttranslational modification] 637381000426 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637381000427 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 637381000428 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 637381000429 putative active site [active] 637381000430 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 637381000431 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637381000432 active site 637381000433 motif I; other site 637381000434 motif II; other site 637381000435 Cupin domain; Region: Cupin_2; cl09118 637381000436 potential frameshift: common BLAST hit: gi|226225279|ref|YP_002759386.1| transcription regulator 637381000437 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 637381000438 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 637381000439 DNA binding residues [nucleotide binding] 637381000440 putative dimer interface [polypeptide binding]; other site 637381000441 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 637381000442 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 637381000443 Transcriptional regulators [Transcription]; Region: MarR; COG1846 637381000444 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381000445 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 637381000446 MatE; Region: MatE; cl10513 637381000447 MatE; Region: MatE; cl10513 637381000448 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 637381000449 dimer interface [polypeptide binding]; other site 637381000450 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637381000451 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 637381000452 DNA binding residues [nucleotide binding] 637381000453 drug binding residues [chemical binding]; other site 637381000454 dimer interface [polypeptide binding]; other site 637381000455 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination...; Region: GlcN6P_deaminase; cd01399 637381000456 active site 637381000457 trimer interface [polypeptide binding]; other site 637381000458 allosteric site; other site 637381000459 active site lid [active] 637381000460 hexamer (dimer of trimers) interface [polypeptide binding]; other site 637381000461 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 637381000462 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 637381000463 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 637381000464 nucleoside/Zn binding site; other site 637381000465 dimer interface [polypeptide binding]; other site 637381000466 catalytic motif [active] 637381000467 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 637381000468 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 637381000469 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 637381000470 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 637381000471 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 637381000472 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 637381000473 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381000474 Walker A/P-loop; other site 637381000475 ATP binding site [chemical binding]; other site 637381000476 Q-loop/lid; other site 637381000477 ABC transporter signature motif; other site 637381000478 Walker B; other site 637381000479 D-loop; other site 637381000480 H-loop/switch region; other site 637381000481 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 637381000482 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 637381000483 The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd...; Region: ABCC_cytochrome_bd; cd03247 637381000484 Walker A/P-loop; other site 637381000485 ATP binding site [chemical binding]; other site 637381000486 Q-loop/lid; other site 637381000487 ABC transporter signature motif; other site 637381000488 Walker B; other site 637381000489 D-loop; other site 637381000490 H-loop/switch region; other site 637381000491 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 637381000492 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 637381000493 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 637381000494 N- and C-terminal domain interface [polypeptide binding]; other site 637381000495 putative active site [active] 637381000496 catalytic site [active] 637381000497 metal binding site [ion binding]; metal-binding site 637381000498 carbohydrate binding site [chemical binding]; other site 637381000499 ATP binding site [chemical binding]; other site 637381000500 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637381000501 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 637381000502 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 637381000503 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637381000504 Walker A motif; other site 637381000505 ATP binding site [chemical binding]; other site 637381000506 Walker B motif; other site 637381000507 arginine finger; other site 637381000508 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 637381000509 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 637381000510 recombination protein RecR; Reviewed; Region: recR; PRK00076 637381000511 RecR protein; Region: RecR; pfam02132 637381000512 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 637381000513 putative active site [active] 637381000514 putative metal-binding site [ion binding]; other site 637381000515 tetramer interface [polypeptide binding]; other site 637381000516 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 637381000517 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 637381000518 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637381000519 active site 637381000520 catalytic tetrad [active] 637381000521 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 637381000522 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637381000523 active site 637381000524 motif I; other site 637381000525 motif II; other site 637381000526 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637381000527 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 637381000528 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 637381000529 putative active site [active] 637381000530 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cl00025 637381000531 DAK2 domain; Region: Dak2; cl03685 637381000532 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 637381000533 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 637381000534 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 637381000535 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and...; Region: Orn_deC_like; cd00615 637381000536 homodimer interface [polypeptide binding]; other site 637381000537 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637381000538 catalytic residue [active] 637381000539 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 637381000540 thymidylate kinase; Validated; Region: tmk; PRK00698 637381000541 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 637381000542 TMP-binding site; other site 637381000543 ATP-binding site [chemical binding]; other site 637381000544 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 637381000545 autolysin; Reviewed; Region: PRK06347 637381000546 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 637381000547 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 637381000548 putative peptidoglycan binding site; other site 637381000549 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 637381000550 putative peptidoglycan binding site; other site 637381000551 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 637381000552 putative peptidoglycan binding site; other site 637381000553 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 637381000554 putative peptidoglycan binding site; other site 637381000555 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637381000556 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637381000557 magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524 637381000558 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 637381000559 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 637381000560 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637381000561 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 637381000562 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 637381000563 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 637381000564 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 637381000565 methionine cluster; other site 637381000566 active site 637381000567 phosphorylation site [posttranslational modification] 637381000568 metal binding site [ion binding]; metal-binding site 637381000569 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637381000570 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564 637381000571 active site 637381000572 P-loop; other site 637381000573 phosphorylation site [posttranslational modification] 637381000574 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; cl00903 637381000575 Potassium-transporting ATPase A subunit; Region: KdpA; pfam03814 637381000576 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 637381000577 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 637381000578 K+-transporting ATPase, c chain; Region: KdpC; cl00944 637381000579 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 637381000580 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 637381000581 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 637381000582 Ligand Binding Site [chemical binding]; other site 637381000583 GAF domain; Region: GAF; cl00853 637381000584 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637381000585 dimer interface [polypeptide binding]; other site 637381000586 phosphorylation site [posttranslational modification] 637381000587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637381000588 ATP binding site [chemical binding]; other site 637381000589 Mg2+ binding site [ion binding]; other site 637381000590 G-X-G motif; other site 637381000591 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 637381000592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637381000593 active site 637381000594 phosphorylation site [posttranslational modification] 637381000595 intermolecular recognition site; other site 637381000596 dimerization interface [polypeptide binding]; other site 637381000597 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637381000598 DNA binding site [nucleotide binding] 637381000599 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 637381000600 DNA polymerase IV; Reviewed; Region: PRK03103 637381000601 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 637381000602 active site 637381000603 DNA binding site [nucleotide binding] 637381000604 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 637381000605 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 637381000606 Ligand Binding Site [chemical binding]; other site 637381000607 Helix-turn-helix domain; Region: HTH_18; pfam12833 637381000608 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 637381000609 active site 637381000610 metal binding site [ion binding]; metal-binding site 637381000611 Protein of unknown function (DUF419); Region: DUF419; cl15265 637381000612 Predicted membrane protein [Function unknown]; Region: COG4905 637381000613 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 637381000614 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 637381000615 PRD domain; Region: PRD; pfam00874 637381000616 PRD domain; Region: PRD; pfam00874 637381000617 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 637381000618 P-loop; other site 637381000619 active site 637381000620 phosphorylation site [posttranslational modification] 637381000621 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637381000622 active site 637381000623 phosphorylation site [posttranslational modification] 637381000624 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637381000625 active site 637381000626 phosphorylation site [posttranslational modification] 637381000627 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 637381000628 P-loop; other site 637381000629 active site 637381000630 phosphorylation site [posttranslational modification] 637381000631 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 637381000632 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 637381000633 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 637381000634 putative NAD(P) binding site [chemical binding]; other site 637381000635 catalytic Zn binding site [ion binding]; other site 637381000636 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 637381000637 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 637381000638 putative NAD(P) binding site [chemical binding]; other site 637381000639 catalytic Zn binding site [ion binding]; other site 637381000640 structural Zn binding site [ion binding]; other site 637381000641 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 637381000642 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 637381000643 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 637381000644 substrate binding site [chemical binding]; other site 637381000645 hexamer interface [polypeptide binding]; other site 637381000646 metal binding site [ion binding]; metal-binding site 637381000647 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 637381000648 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 637381000649 TPP-binding site [chemical binding]; other site 637381000650 dimer interface [polypeptide binding]; other site 637381000651 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 637381000652 PYR/PP interface [polypeptide binding]; other site 637381000653 dimer interface [polypeptide binding]; other site 637381000654 TPP binding site [chemical binding]; other site 637381000655 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 637381000656 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 637381000657 substrate binding site [chemical binding]; other site 637381000658 hexamer interface [polypeptide binding]; other site 637381000659 metal binding site [ion binding]; metal-binding site 637381000660 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 637381000661 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637381000662 Coenzyme A binding pocket [chemical binding]; other site 637381000663 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 637381000664 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 637381000665 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 637381000666 S17 interaction site [polypeptide binding]; other site 637381000667 S8 interaction site; other site 637381000668 16S rRNA interaction site [nucleotide binding]; other site 637381000669 streptomycin interaction site [chemical binding]; other site 637381000670 23S rRNA interaction site [nucleotide binding]; other site 637381000671 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 637381000672 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 637381000673 elongation factor G; Reviewed; Region: PRK00007 637381000674 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 637381000675 G1 box; other site 637381000676 putative GEF interaction site [polypeptide binding]; other site 637381000677 GTP/Mg2+ binding site [chemical binding]; other site 637381000678 Switch I region; other site 637381000679 G2 box; other site 637381000680 G3 box; other site 637381000681 Switch II region; other site 637381000682 G4 box; other site 637381000683 G5 box; other site 637381000684 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 637381000685 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 637381000686 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 637381000687 elongation factor Tu; Reviewed; Region: PRK00049 637381000688 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 637381000689 G1 box; other site 637381000690 GEF interaction site [polypeptide binding]; other site 637381000691 GTP/Mg2+ binding site [chemical binding]; other site 637381000692 Switch I region; other site 637381000693 G2 box; other site 637381000694 G3 box; other site 637381000695 Switch II region; other site 637381000696 G4 box; other site 637381000697 G5 box; other site 637381000698 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 637381000699 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 637381000700 Antibiotic Binding Site [chemical binding]; other site 637381000701 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 637381000702 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381000703 PRD domain; Region: PRD; pfam00874 637381000704 PRD domain; Region: PRD; pfam00874 637381000705 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 637381000706 P-loop; other site 637381000707 active site 637381000708 phosphorylation site [posttranslational modification] 637381000709 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637381000710 active site 637381000711 phosphorylation site [posttranslational modification] 637381000712 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637381000713 active site 637381000714 phosphorylation site [posttranslational modification] 637381000715 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 637381000716 P-loop; other site 637381000717 active site 637381000718 phosphorylation site [posttranslational modification] 637381000719 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 637381000720 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: Php; COG1735 637381000721 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active...; Region: PTE; cd00530 637381000722 active site 637381000723 substrate binding pocket [chemical binding]; other site 637381000724 homodimer interaction site [polypeptide binding]; other site 637381000725 Creatinine amidohydrolase; Region: Creatininase; cl00618 637381000726 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 637381000727 hypothetical protein; Provisional; Region: PRK02947 637381000728 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 637381000729 putative active site [active] 637381000730 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 637381000731 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 637381000732 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 637381000733 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 637381000734 active site 637381000735 metal binding site [ion binding]; metal-binding site 637381000736 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 637381000737 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 637381000738 substrate binding pocket [chemical binding]; other site 637381000739 chain length determination region; other site 637381000740 substrate-Mg2+ binding site; other site 637381000741 catalytic residues [active] 637381000742 aspartate-rich region 1; other site 637381000743 active site lid residues [active] 637381000744 aspartate-rich region 2; other site 637381000745 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973 637381000746 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 637381000747 trimer interface [polypeptide binding]; other site 637381000748 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 637381000749 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381000750 DoxX; Region: DoxX; cl00976 637381000751 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 637381000752 FMN-binding domain; Region: FMN_bind; cl01081 637381000753 FMN-binding domain; Region: FMN_bind; cl01081 637381000754 ApbE family; Region: ApbE; cl00643 637381000755 UbiA prenyltransferase family; Region: UbiA; cl00337 637381000756 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; COG1575 637381000757 Cobalt transport protein; Region: CbiQ; cl00463 637381000758 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 637381000759 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 637381000760 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 637381000761 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 637381000762 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 637381000763 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 637381000764 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 637381000765 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 637381000766 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 637381000767 putative translocon binding site; other site 637381000768 protein-rRNA interface [nucleotide binding]; other site 637381000769 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 637381000770 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 637381000771 G-X-X-G motif; other site 637381000772 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 637381000773 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 637381000774 23S rRNA interface [nucleotide binding]; other site 637381000775 5S rRNA interface [nucleotide binding]; other site 637381000776 putative antibiotic binding site [chemical binding]; other site 637381000777 L25 interface [polypeptide binding]; other site 637381000778 L27 interface [polypeptide binding]; other site 637381000779 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 637381000780 23S rRNA interface [nucleotide binding]; other site 637381000781 putative translocon interaction site; other site 637381000782 signal recognition particle (SRP54) interaction site; other site 637381000783 L23 interface [polypeptide binding]; other site 637381000784 trigger factor interaction site; other site 637381000785 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 637381000786 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 637381000787 KOW motif; Region: KOW; cl00354 637381000788 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 637381000789 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 637381000790 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 637381000791 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 637381000792 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 637381000793 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 637381000794 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 637381000795 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 637381000796 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 637381000797 5S rRNA interface [nucleotide binding]; other site 637381000798 L27 interface [polypeptide binding]; other site 637381000799 23S rRNA interface [nucleotide binding]; other site 637381000800 L5 interface [polypeptide binding]; other site 637381000801 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 637381000802 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 637381000803 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 637381000804 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658 637381000805 23S rRNA binding site [nucleotide binding]; other site 637381000806 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 637381000807 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 637381000808 SecY translocase; Region: SecY; pfam00344 637381000809 adenylate kinase; Reviewed; Region: adk; PRK00279 637381000810 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 637381000811 AMP-binding site [chemical binding]; other site 637381000812 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 637381000813 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 637381000814 rRNA binding site [nucleotide binding]; other site 637381000815 predicted 30S ribosome binding site; other site 637381000816 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 637381000817 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 637381000818 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 637381000819 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 637381000820 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 637381000821 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 637381000822 alphaNTD - beta interaction site [polypeptide binding]; other site 637381000823 alphaNTD homodimer interface [polypeptide binding]; other site 637381000824 alphaNTD - beta' interaction site [polypeptide binding]; other site 637381000825 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 637381000826 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 637381000827 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 637381000828 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 637381000829 MgtC family; Region: MgtC; cl12207 637381000830 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 637381000831 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 637381000832 Walker A/P-loop; other site 637381000833 ATP binding site [chemical binding]; other site 637381000834 Q-loop/lid; other site 637381000835 ABC transporter signature motif; other site 637381000836 Walker B; other site 637381000837 D-loop; other site 637381000838 H-loop/switch region; other site 637381000839 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 637381000840 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 637381000841 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 637381000842 Walker A/P-loop; other site 637381000843 ATP binding site [chemical binding]; other site 637381000844 Q-loop/lid; other site 637381000845 ABC transporter signature motif; other site 637381000846 Walker B; other site 637381000847 D-loop; other site 637381000848 H-loop/switch region; other site 637381000849 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 637381000850 Cobalt transport protein; Region: CbiQ; cl00463 637381000851 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 637381000852 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 637381000853 dimerization interface 3.5A [polypeptide binding]; other site 637381000854 active site 637381000855 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 637381000856 23S rRNA interface [nucleotide binding]; other site 637381000857 L3 interface [polypeptide binding]; other site 637381000858 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 637381000859 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 637381000860 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 637381000861 DNA binding residues [nucleotide binding] 637381000862 putative dimer interface [polypeptide binding]; other site 637381000863 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 637381000864 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637381000865 active site 637381000866 catalytic tetrad [active] 637381000867 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 637381000868 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 637381000869 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 637381000870 UvrB/uvrC motif; Region: UVR; pfam02151 637381000871 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 637381000872 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 637381000873 ADP binding site [chemical binding]; other site 637381000874 phosphagen binding site; other site 637381000875 substrate specificity loop; other site 637381000876 Clp protease ATP binding subunit; Region: clpC; CHL00095 637381000877 Clp amino terminal domain; Region: Clp_N; pfam02861 637381000878 Clp amino terminal domain; Region: Clp_N; pfam02861 637381000879 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637381000880 Walker A motif; other site 637381000881 ATP binding site [chemical binding]; other site 637381000882 Walker B motif; other site 637381000883 arginine finger; other site 637381000884 UvrB/uvrC motif; Region: UVR; pfam02151 637381000885 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637381000886 Walker A motif; other site 637381000887 ATP binding site [chemical binding]; other site 637381000888 Walker B motif; other site 637381000889 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 637381000890 DNA repair protein RadA; Provisional; Region: PRK11823 637381000891 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 637381000892 Walker A motif/ATP binding site; other site 637381000893 ATP binding site [chemical binding]; other site 637381000894 Walker B motif; other site 637381000895 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 637381000896 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 637381000897 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 637381000898 putative active site [active] 637381000899 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 637381000900 substrate binding site [chemical binding]; other site 637381000901 dimer interface [polypeptide binding]; other site 637381000902 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554 637381000903 homotrimer interaction site [polypeptide binding]; other site 637381000904 zinc binding site [ion binding]; other site 637381000905 CDP-binding sites; other site 637381000906 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 637381000907 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 637381000908 HIGH motif; other site 637381000909 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 637381000910 active site 637381000911 KMSKS motif; other site 637381000912 serine O-acetyltransferase; Region: cysE; TIGR01172 637381000913 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 637381000914 trimer interface [polypeptide binding]; other site 637381000915 active site 637381000916 substrate binding site [chemical binding]; other site 637381000917 CoA binding site [chemical binding]; other site 637381000918 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 637381000919 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 637381000920 active site 637381000921 HIGH motif; other site 637381000922 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 637381000923 KMSKS motif; other site 637381000924 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 637381000925 tRNA binding surface [nucleotide binding]; other site 637381000926 anticodon binding site; other site 637381000927 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 637381000928 active site 637381000929 metal binding site [ion binding]; metal-binding site 637381000930 dimerization interface [polypeptide binding]; other site 637381000931 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 637381000932 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 637381000933 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 637381000934 YacP-like NYN domain; Region: NYN_YacP; cl01491 637381000935 RNA polymerase factor sigma-70; Validated; Region: PRK08295 637381000936 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637381000937 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 637381000938 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 637381000939 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 637381000940 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 637381000941 putative homodimer interface [polypeptide binding]; other site 637381000942 KOW motif; Region: KOW; cl00354 637381000943 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 637381000944 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 637381000945 23S rRNA interface [nucleotide binding]; other site 637381000946 L7/L12 interface [polypeptide binding]; other site 637381000947 putative thiostrepton binding site; other site 637381000948 L25 interface [polypeptide binding]; other site 637381000949 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 637381000950 mRNA/rRNA interface [nucleotide binding]; other site 637381000951 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 637381000952 23S rRNA interface [nucleotide binding]; other site 637381000953 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 637381000954 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 637381000955 core dimer interface [polypeptide binding]; other site 637381000956 peripheral dimer interface [polypeptide binding]; other site 637381000957 L10 interface [polypeptide binding]; other site 637381000958 L11 interface [polypeptide binding]; other site 637381000959 putative EF-Tu interaction site [polypeptide binding]; other site 637381000960 putative EF-G interaction site [polypeptide binding]; other site 637381000961 Protein of unknown function (DUF1307); Region: DUF1307; cl01981 637381000962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637381000963 S-adenosylmethionine binding site [chemical binding]; other site 637381000964 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 637381000965 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 637381000966 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637381000967 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637381000968 DNA binding site [nucleotide binding] 637381000969 domain linker motif; other site 637381000970 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 637381000971 putative dimerization interface [polypeptide binding]; other site 637381000972 putative ligand binding site [chemical binding]; other site 637381000973 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 637381000974 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637381000975 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 637381000976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381000977 dimer interface [polypeptide binding]; other site 637381000978 conserved gate region; other site 637381000979 putative PBP binding loops; other site 637381000980 ABC-ATPase subunit interface; other site 637381000981 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 637381000982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381000983 dimer interface [polypeptide binding]; other site 637381000984 conserved gate region; other site 637381000985 putative PBP binding loops; other site 637381000986 ABC-ATPase subunit interface; other site 637381000987 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 637381000988 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 637381000989 sucrose phosphorylase; Provisional; Region: PRK13840 637381000990 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 637381000991 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 637381000992 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 637381000993 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 637381000994 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 637381000995 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 637381000996 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 637381000997 RPB10 interaction site [polypeptide binding]; other site 637381000998 RPB1 interaction site [polypeptide binding]; other site 637381000999 RPB11 interaction site [polypeptide binding]; other site 637381001000 RPB3 interaction site [polypeptide binding]; other site 637381001001 RPB12 interaction site [polypeptide binding]; other site 637381001002 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 637381001003 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 637381001004 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 637381001005 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 637381001006 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 637381001007 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 637381001008 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 637381001009 G-loop; other site 637381001010 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 637381001011 DNA binding site [nucleotide binding] 637381001012 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 637381001013 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637381001014 active site 637381001015 motif I; other site 637381001016 motif II; other site 637381001017 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 637381001018 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 637381001019 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 637381001020 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309 637381001021 Substrate binding site [chemical binding]; other site 637381001022 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637381001023 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637381001024 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637381001025 LRR adjacent; Region: LRR_adjacent; pfam08191 637381001026 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 637381001027 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 637381001028 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 637381001029 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 637381001030 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309 637381001031 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637381001032 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637381001033 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637381001034 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637381001035 LRR adjacent; Region: LRR_adjacent; pfam08191 637381001036 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 637381001037 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 637381001038 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 637381001039 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309 637381001040 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637381001041 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637381001042 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637381001043 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637381001044 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637381001045 LRR adjacent; Region: LRR_adjacent; pfam08191 637381001046 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 637381001047 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 637381001048 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 637381001049 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 637381001050 LRR adjacent; Region: LRR_adjacent; pfam08191 637381001051 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 637381001052 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 637381001053 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 637381001054 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 637381001055 metal binding site [ion binding]; metal-binding site 637381001056 dimer interface [polypeptide binding]; other site 637381001057 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381001058 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 637381001059 Zn binding site [ion binding]; other site 637381001060 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 637381001061 Zn binding site [ion binding]; other site 637381001062 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637381001063 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 637381001064 catalytic core [active] 637381001065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381001066 dimer interface [polypeptide binding]; other site 637381001067 conserved gate region; other site 637381001068 putative PBP binding loops; other site 637381001069 ABC-ATPase subunit interface; other site 637381001070 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 637381001071 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 637381001072 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 637381001073 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 637381001074 sugar phosphate phosphatase; Provisional; Region: PRK10513 637381001075 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637381001076 active site 637381001077 motif I; other site 637381001078 motif II; other site 637381001079 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637381001080 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637381001081 Coenzyme A binding pocket [chemical binding]; other site 637381001082 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 637381001083 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 637381001084 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637381001085 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637381001086 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 637381001087 active site 637381001088 motif I; other site 637381001089 motif II; other site 637381001090 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637381001091 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381001092 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 637381001093 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 637381001094 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 637381001095 Walker A/P-loop; other site 637381001096 ATP binding site [chemical binding]; other site 637381001097 Q-loop/lid; other site 637381001098 ABC transporter signature motif; other site 637381001099 Walker B; other site 637381001100 D-loop; other site 637381001101 H-loop/switch region; other site 637381001102 TOBE domain; Region: TOBE_2; cl01440 637381001103 ATP cone domain; Region: ATP-cone; pfam03477 637381001104 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 637381001105 Class III ribonucleotide reductase; Region: RNR_III; cd01675 637381001106 effector binding site; other site 637381001107 active site 637381001108 Zn binding site [ion binding]; other site 637381001109 glycine loop; other site 637381001110 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 637381001111 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 637381001112 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 637381001113 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 637381001114 Predicted amidohydrolase [General function prediction only]; Region: COG0388 637381001115 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 637381001116 putative active site [active] 637381001117 catalytic triad [active] 637381001118 putative dimer interface [polypeptide binding]; other site 637381001119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381001120 dimer interface [polypeptide binding]; other site 637381001121 conserved gate region; other site 637381001122 ABC-ATPase subunit interface; other site 637381001123 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 637381001124 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258 637381001125 Walker A/P-loop; other site 637381001126 ATP binding site [chemical binding]; other site 637381001127 Q-loop/lid; other site 637381001128 ABC transporter signature motif; other site 637381001129 Walker B; other site 637381001130 D-loop; other site 637381001131 H-loop/switch region; other site 637381001132 NIL domain; Region: NIL; cl09633 637381001133 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 637381001134 aspartate aminotransferase; Provisional; Region: PRK07681 637381001135 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637381001136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637381001137 homodimer interface [polypeptide binding]; other site 637381001138 catalytic residue [active] 637381001139 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637381001140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637381001141 active site 637381001142 phosphorylation site [posttranslational modification] 637381001143 intermolecular recognition site; other site 637381001144 dimerization interface [polypeptide binding]; other site 637381001145 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637381001146 DNA binding site [nucleotide binding] 637381001147 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 637381001148 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 637381001149 dimerization interface [polypeptide binding]; other site 637381001150 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 637381001151 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637381001152 dimer interface [polypeptide binding]; other site 637381001153 phosphorylation site [posttranslational modification] 637381001154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637381001155 ATP binding site [chemical binding]; other site 637381001156 Mg2+ binding site [ion binding]; other site 637381001157 G-X-G motif; other site 637381001158 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 637381001159 YycH protein; Region: YycH; pfam07435 637381001160 YycH protein; Region: YycI; cl02015 637381001161 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637381001162 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 637381001163 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 637381001164 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 637381001165 protein binding site [polypeptide binding]; other site 637381001166 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 637381001167 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637381001168 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381001169 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 637381001170 dimerization interface [polypeptide binding]; other site 637381001171 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH...; Region: NfsA_FRP; cd02146 637381001172 dimer interface [polypeptide binding]; other site 637381001173 FMN binding site [chemical binding]; other site 637381001174 NADPH bind site [chemical binding]; other site 637381001175 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 637381001176 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381001177 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381001178 PRD domain; Region: PRD; pfam00874 637381001179 PRD domain; Region: PRD; pfam00874 637381001180 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 637381001181 P-loop; other site 637381001182 active site 637381001183 phosphorylation site [posttranslational modification] 637381001184 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637381001185 active site 637381001186 phosphorylation site [posttranslational modification] 637381001187 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637381001188 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564 637381001189 active site 637381001190 P-loop; other site 637381001191 phosphorylation site [posttranslational modification] 637381001192 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 637381001193 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 637381001194 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 637381001195 methionine cluster; other site 637381001196 active site 637381001197 phosphorylation site [posttranslational modification] 637381001198 metal binding site [ion binding]; metal-binding site 637381001199 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 637381001200 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 637381001201 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 637381001202 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637381001203 catalytic residue [active] 637381001204 YdjC-like protein; Region: YdjC; cl01344 637381001205 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 637381001206 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 637381001207 substrate binding site [chemical binding]; other site 637381001208 multimerization interface [polypeptide binding]; other site 637381001209 ATP binding site [chemical binding]; other site 637381001210 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 637381001211 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 637381001212 dimer interface [polypeptide binding]; other site 637381001213 substrate binding site [chemical binding]; other site 637381001214 ATP binding site [chemical binding]; other site 637381001215 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 637381001216 thiamine phosphate binding site [chemical binding]; other site 637381001217 active site 637381001218 pyrophosphate binding site [ion binding]; other site 637381001219 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 637381001220 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 637381001221 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 637381001222 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 637381001223 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 637381001224 putative catalytic site [active] 637381001225 putative metal binding site [ion binding]; other site 637381001226 putative phosphate binding site [ion binding]; other site 637381001227 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637381001228 non-specific DNA binding site [nucleotide binding]; other site 637381001229 salt bridge; other site 637381001230 sequence-specific DNA binding site [nucleotide binding]; other site 637381001231 C-terminal domain; Region: RGG_Cterm; TIGR01716 637381001232 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 637381001233 C-terminal domain; Region: RGG_Cterm; TIGR01716 637381001234 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 637381001235 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 637381001236 Gram-positive; Region: pullulan_Gpos; TIGR02102 637381001237 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 637381001238 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309 637381001239 Leucine-rich repeats; other site 637381001240 Substrate binding site [chemical binding]; other site 637381001241 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637381001242 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637381001243 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637381001244 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309 637381001245 Leucine-rich repeats; other site 637381001246 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637381001247 Substrate binding site [chemical binding]; other site 637381001248 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637381001249 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637381001250 LRR adjacent; Region: LRR_adjacent; pfam08191 637381001251 MucBP domain; Region: MucBP; pfam06458 637381001252 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 637381001253 Enterocin A Immunity; Region: EntA_Immun; pfam08951 637381001254 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 637381001255 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 637381001256 TPP-binding site [chemical binding]; other site 637381001257 dimer interface [polypeptide binding]; other site 637381001258 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 637381001259 PYR/PP interface [polypeptide binding]; other site 637381001260 dimer interface [polypeptide binding]; other site 637381001261 TPP binding site [chemical binding]; other site 637381001262 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637381001263 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 637381001264 active site 637381001265 intersubunit interactions; other site 637381001266 catalytic residue [active] 637381001267 short chain dehydrogenase; Provisional; Region: PRK06841 637381001268 classical (c) SDRs; Region: SDR_c; cd05233 637381001269 NAD(P) binding site [chemical binding]; other site 637381001270 active site 637381001271 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 637381001272 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 637381001273 substrate binding site [chemical binding]; other site 637381001274 dimer interface [polypeptide binding]; other site 637381001275 catalytic triad [active] 637381001276 DAK2 domain; Region: Dak2; cl03685 637381001277 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 637381001278 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 637381001279 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cl00025 637381001280 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 637381001281 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381001282 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 637381001283 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637381001284 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 637381001285 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 637381001286 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381001287 putative oxidoreductase; Provisional; Region: PRK10206 637381001288 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381001289 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 637381001290 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637381001291 active site 637381001292 phosphorylation site [posttranslational modification] 637381001293 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 637381001294 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 637381001295 P-loop; other site 637381001296 active site 637381001297 phosphorylation site [posttranslational modification] 637381001298 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637381001299 hypothetical protein; Provisional; Region: PRK08185 637381001300 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 637381001301 intersubunit interface [polypeptide binding]; other site 637381001302 active site 637381001303 zinc binding site [ion binding]; other site 637381001304 Na+ binding site [ion binding]; other site 637381001305 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 637381001306 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381001307 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 637381001308 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 637381001309 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 637381001310 Iron permease FTR1 family; Region: FTR1; cl00475 637381001311 Imelysin; Region: Peptidase_M75; cl09159 637381001312 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 637381001313 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 637381001314 nudix motif; other site 637381001315 Domain of unknown function DUF28; Region: DUF28; cl00361 637381001316 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 637381001317 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 637381001318 PhnA protein; Region: PhnA; pfam03831 637381001319 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 637381001320 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637381001321 DNA-binding site [nucleotide binding]; DNA binding site 637381001322 UTRA domain; Region: UTRA; cl01230 637381001323 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 637381001324 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 637381001325 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637381001326 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564 637381001327 active site 637381001328 P-loop; other site 637381001329 phosphorylation site [posttranslational modification] 637381001330 Predicted transcriptional regulator [Transcription]; Region: COG2378 637381001331 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381001332 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 637381001333 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381001334 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 637381001335 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 637381001336 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 637381001337 tetrameric interface [polypeptide binding]; other site 637381001338 NAD binding site [chemical binding]; other site 637381001339 catalytic residues [active] 637381001340 KduI/IolB family; Region: KduI; cl01508 637381001341 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 637381001342 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 637381001343 substrate binding site [chemical binding]; other site 637381001344 ATP binding site [chemical binding]; other site 637381001345 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 637381001346 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 637381001347 PYR/PP interface [polypeptide binding]; other site 637381001348 dimer interface [polypeptide binding]; other site 637381001349 TPP binding site [chemical binding]; other site 637381001350 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 637381001351 TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 637381001352 TPP-binding site; other site 637381001353 Protein of unknown function (DUF419); Region: DUF419; cl15265 637381001354 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 637381001355 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 637381001356 ligand binding site [chemical binding]; other site 637381001357 active site 637381001358 UGI interface [polypeptide binding]; other site 637381001359 catalytic site [active] 637381001360 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 637381001361 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4864 637381001362 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 637381001363 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 637381001364 NlpC/P60 family; Region: NLPC_P60; cl11438 637381001365 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637381001366 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 637381001367 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381001368 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 637381001369 putative hydrophobic ligand binding site [chemical binding]; other site 637381001370 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637381001371 active site 637381001372 phosphorylation site [posttranslational modification] 637381001373 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 637381001374 P-loop; other site 637381001375 active site 637381001376 phosphorylation site [posttranslational modification] 637381001377 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637381001378 alpha-mannosidase; Provisional; Region: PRK09819 637381001379 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 637381001380 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 637381001381 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 637381001382 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381001383 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381001384 PRD domain; Region: PRD; pfam00874 637381001385 PRD domain; Region: PRD; pfam00874 637381001386 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 637381001387 P-loop; other site 637381001388 active site 637381001389 phosphorylation site [posttranslational modification] 637381001390 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637381001391 active site 637381001392 phosphorylation site [posttranslational modification] 637381001393 Phosphate transporter family; Region: PHO4; cl00396 637381001394 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 637381001395 putative metal binding site [ion binding]; other site 637381001396 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 637381001397 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 637381001398 trimer interface [polypeptide binding]; other site 637381001399 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 637381001400 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 637381001401 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309 637381001402 Leucine-rich repeats; other site 637381001403 Substrate binding site [chemical binding]; other site 637381001404 LRR adjacent; Region: LRR_adjacent; pfam08191 637381001405 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 637381001406 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 637381001407 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 637381001408 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 637381001409 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 637381001410 phosphoenolpyruvate synthase; Validated; Region: PRK06241 637381001411 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 637381001412 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 637381001413 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 637381001414 ZIP Zinc transporter; Region: Zip; pfam02535 637381001415 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 637381001416 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637381001417 salt bridge; other site 637381001418 non-specific DNA binding site [nucleotide binding]; other site 637381001419 sequence-specific DNA binding site [nucleotide binding]; other site 637381001420 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 637381001421 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637381001422 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 637381001423 active site 637381001424 motif I; other site 637381001425 motif II; other site 637381001426 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637381001427 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 637381001428 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381001429 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 637381001430 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637381001431 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 637381001432 DNA binding residues [nucleotide binding] 637381001433 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 637381001434 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 637381001435 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381001436 PRD domain; Region: PRD; pfam00874 637381001437 PRD domain; Region: PRD; pfam00874 637381001438 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 637381001439 P-loop; other site 637381001440 active site 637381001441 phosphorylation site [posttranslational modification] 637381001442 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637381001443 active site 637381001444 phosphorylation site [posttranslational modification] 637381001445 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637381001446 active site 637381001447 phosphorylation site [posttranslational modification] 637381001448 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 637381001449 P-loop; other site 637381001450 active site 637381001451 phosphorylation site [posttranslational modification] 637381001452 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637381001453 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 637381001454 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 637381001455 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 637381001456 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637381001457 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381001458 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 637381001459 dimerization interface [polypeptide binding]; other site 637381001460 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 637381001461 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 637381001462 active site 637381001463 substrate binding site [chemical binding]; other site 637381001464 trimer interface [polypeptide binding]; other site 637381001465 CoA binding site [chemical binding]; other site 637381001466 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 637381001467 classical (c) SDRs; Region: SDR_c; cd05233 637381001468 NAD(P) binding site [chemical binding]; other site 637381001469 active site 637381001470 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 637381001471 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637381001472 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 637381001473 LRR adjacent; Region: LRR_adjacent; pfam08191 637381001474 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 637381001475 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 637381001476 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 637381001477 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 637381001478 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 637381001479 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309 637381001480 LRR adjacent; Region: LRR_adjacent; pfam08191 637381001481 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 637381001482 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 637381001483 Predicted transcriptional regulator [Transcription]; Region: COG1959 637381001484 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381001485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381001486 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 637381001487 NAD(P) binding site [chemical binding]; other site 637381001488 active site 637381001489 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 637381001490 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 637381001491 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 637381001492 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 637381001493 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 637381001494 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 637381001495 Predicted membrane protein [Function unknown]; Region: COG1511 637381001496 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 637381001497 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 637381001498 ABC-2 type transporter; Region: ABC2_membrane; cl11417 637381001499 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381001500 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 637381001501 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381001502 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 637381001503 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-...; Region: Ntn_PVA; cd00542 637381001504 active site 637381001505 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 637381001506 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 637381001507 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637381001508 catalytic residue [active] 637381001509 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637381001510 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 637381001511 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 637381001512 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 637381001513 Protein of unknown function DUF58; Region: DUF58; pfam01882 637381001514 MoxR-like ATPases [General function prediction only]; Region: COG0714 637381001515 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381001516 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 637381001517 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 637381001518 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 637381001519 Sodium:solute symporter family; Region: SSF; cl00456 637381001520 Uncharacterized conserved protein [Function unknown]; Region: COG3535 637381001521 Protein of unknown function (DUF917); Region: DUF917; pfam06032 637381001522 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 637381001523 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 637381001524 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 637381001525 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 637381001526 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 637381001527 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 637381001528 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 637381001529 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 637381001530 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 637381001531 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637381001532 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 637381001533 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl01939 637381001534 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 637381001535 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 637381001536 FeS/SAM binding site; other site 637381001537 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 637381001538 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 637381001539 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a beta-...; Region: Arsenite_oxidase; cd02135 637381001540 putative FMN binding site [chemical binding]; other site 637381001541 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 637381001542 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 637381001543 nudix motif; other site 637381001544 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637381001545 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381001546 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 637381001547 putative dimerization interface [polypeptide binding]; other site 637381001548 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 637381001549 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as...; Region: OYE_like_FMN_family; cd02803 637381001550 active site 637381001551 FMN binding site [chemical binding]; other site 637381001552 substrate binding site [chemical binding]; other site 637381001553 putative catalytic residue [active] 637381001554 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381001555 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 637381001556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381001557 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 637381001558 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 637381001559 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 637381001560 shikimate binding site; other site 637381001561 NAD(P) binding site [chemical binding]; other site 637381001562 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 637381001563 3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093 637381001564 active site 637381001565 catalytic residue [active] 637381001566 dimer interface [polypeptide binding]; other site 637381001567 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637381001568 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381001569 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 637381001570 dimerization interface [polypeptide binding]; other site 637381001571 substrate binding pocket [chemical binding]; other site 637381001572 Predicted acyl esterases [General function prediction only]; Region: COG2936 637381001573 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 637381001574 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 637381001575 active site 637381001576 catalytic triad [active] 637381001577 oxyanion hole [active] 637381001578 EamA-like transporter family; Region: EamA; cl01037 637381001579 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 637381001580 EamA-like transporter family; Region: EamA; cl01037 637381001581 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 637381001582 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 637381001583 active site 637381001584 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 637381001585 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 637381001586 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 637381001587 substrate binding site [chemical binding]; other site 637381001588 hexamer interface [polypeptide binding]; other site 637381001589 metal binding site [ion binding]; metal-binding site 637381001590 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 637381001591 catalytic residue [active] 637381001592 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 637381001593 PRD domain; Region: PRD; pfam00874 637381001594 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 637381001595 P-loop; other site 637381001596 active site 637381001597 phosphorylation site [posttranslational modification] 637381001598 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637381001599 active site 637381001600 phosphorylation site [posttranslational modification] 637381001601 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-...; Region: SIS_Kpsf; cd05014 637381001602 putative active site [active] 637381001603 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637381001604 active site 637381001605 phosphorylation site [posttranslational modification] 637381001606 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 637381001607 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 637381001608 substrate binding site [chemical binding]; other site 637381001609 hexamer interface [polypeptide binding]; other site 637381001610 metal binding site [ion binding]; metal-binding site 637381001611 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 637381001612 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 637381001613 putative NAD(P) binding site [chemical binding]; other site 637381001614 catalytic Zn binding site [ion binding]; other site 637381001615 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 637381001616 P-loop; other site 637381001617 active site 637381001618 phosphorylation site [posttranslational modification] 637381001619 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 637381001620 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 637381001621 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 637381001622 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 637381001623 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 637381001624 catalytic triad [active] 637381001625 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807 637381001626 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381001627 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637381001628 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 637381001629 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 637381001630 Ligand Binding Site [chemical binding]; other site 637381001631 NUP50 (Nucleoporin 50 kDa); Region: NUP50; pfam08911 637381001632 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 637381001633 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 637381001634 putative active site [active] 637381001635 putative metal binding site [ion binding]; other site 637381001636 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 637381001637 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637381001638 catalytic core [active] 637381001639 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637381001640 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 637381001641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637381001642 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637381001643 putative substrate translocation pore; other site 637381001644 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 637381001645 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381001646 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 637381001647 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 637381001648 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 637381001649 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 637381001650 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637381001651 ATP binding site [chemical binding]; other site 637381001652 putative Mg++ binding site [ion binding]; other site 637381001653 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 637381001654 HsdM N-terminal domain; Region: HsdM_N; pfam12161 637381001655 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 637381001656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637381001657 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 637381001658 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 637381001659 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 637381001660 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 637381001661 Phage integrase family; Region: Phage_integrase; pfam00589 637381001662 Int/Topo IB signature motif; other site 637381001663 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 637381001664 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 637381001665 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 637381001666 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 637381001667 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 637381001668 NAD binding site [chemical binding]; other site 637381001669 sugar binding site [chemical binding]; other site 637381001670 divalent metal binding site [ion binding]; other site 637381001671 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637381001672 dimer interface [polypeptide binding]; other site 637381001673 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 637381001674 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 637381001675 putative active site [active] 637381001676 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 637381001677 Sulfate transporter family; Region: Sulfate_transp; cl00967 637381001678 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 637381001679 Uncharacterized conserved protein [Function unknown]; Region: COG5361 637381001680 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 637381001681 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 637381001682 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 637381001683 DNA binding residues [nucleotide binding] 637381001684 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 637381001685 dimer interface [polypeptide binding]; other site 637381001686 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 637381001687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5298 637381001688 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 637381001689 DXD motif; other site 637381001690 cellulose synthase regulator protein; Provisional; Region: PRK11114 637381001691 cellulose synthase regulator protein; Provisional; Region: PRK11114 637381001692 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 637381001693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637381001694 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 637381001695 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 637381001696 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637381001697 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637381001698 DNA binding site [nucleotide binding] 637381001699 domain linker motif; other site 637381001700 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 637381001701 putative dimerization interface [polypeptide binding]; other site 637381001702 putative ligand binding site [chemical binding]; other site 637381001703 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 637381001704 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 637381001705 NAD binding site [chemical binding]; other site 637381001706 sugar binding site [chemical binding]; other site 637381001707 divalent metal binding site [ion binding]; other site 637381001708 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637381001709 dimer interface [polypeptide binding]; other site 637381001710 allantoate amidohydrolase; Reviewed; Region: PRK09290 637381001711 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 637381001712 active site 637381001713 metal binding site [ion binding]; metal-binding site 637381001714 dimer interface [polypeptide binding]; other site 637381001715 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 637381001716 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 637381001717 metal binding site [ion binding]; metal-binding site 637381001718 putative dimer interface [polypeptide binding]; other site 637381001719 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 637381001720 Beta-lactamase; Region: Beta-lactamase; cl01009 637381001721 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 637381001722 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 637381001723 intersubunit interface [polypeptide binding]; other site 637381001724 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 637381001725 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 637381001726 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 637381001727 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 637381001728 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 637381001729 Glucitol operon activator protein (GutM); Region: GutM; cl01890 637381001730 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 637381001731 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 637381001732 SAF domain; Region: SAF; cl00555 637381001733 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 637381001734 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 637381001735 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 637381001736 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 637381001737 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 637381001738 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 637381001739 FOG: CBS domain [General function prediction only]; Region: COG0517 637381001740 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cd02205 637381001741 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 637381001742 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 637381001743 dimer interface [polypeptide binding]; other site 637381001744 active site 637381001745 metal binding site [ion binding]; metal-binding site 637381001746 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 637381001747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637381001748 putative substrate translocation pore; other site 637381001749 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 637381001750 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 637381001751 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637381001752 catalytic core [active] 637381001753 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637381001754 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637381001755 catalytic core [active] 637381001756 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 637381001757 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 637381001758 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 637381001759 glutamate dehydrogenase; Provisional; Region: PRK09414 637381001760 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 637381001761 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 637381001762 NAD(P) binding site [chemical binding]; other site 637381001763 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 637381001764 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 637381001765 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 637381001766 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 637381001767 substrate binding site [chemical binding]; other site 637381001768 glutamase interaction surface [polypeptide binding]; other site 637381001769 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 637381001770 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 637381001771 catalytic residues [active] 637381001772 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 637381001773 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 637381001774 putative active site [active] 637381001775 oxyanion strand; other site 637381001776 catalytic triad [active] 637381001777 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 637381001778 putative active site pocket [active] 637381001779 4-fold oligomerization interface [polypeptide binding]; other site 637381001780 metal binding residues [ion binding]; metal-binding site 637381001781 3-fold/trimer interface [polypeptide binding]; other site 637381001782 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 637381001783 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 637381001784 NAD binding site [chemical binding]; other site 637381001785 dimerization interface [polypeptide binding]; other site 637381001786 product binding site; other site 637381001787 substrate binding site [chemical binding]; other site 637381001788 zinc binding site [ion binding]; other site 637381001789 catalytic residues [active] 637381001790 ATP phosphoribosyltransferase; Region: HisG; cl15266 637381001791 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 637381001792 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 637381001793 dimer interface [polypeptide binding]; other site 637381001794 motif 1; other site 637381001795 active site 637381001796 motif 2; other site 637381001797 motif 3; other site 637381001798 histidinol-phosphatase; Reviewed; Region: PRK08123 637381001799 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 637381001800 DNA binding site [nucleotide binding] 637381001801 active site 637381001802 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 637381001803 Sulfate transporter family; Region: Sulfate_transp; cl00967 637381001804 Permease family; Region: Xan_ur_permease; pfam00860 637381001805 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 637381001806 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 637381001807 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 637381001808 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637381001809 DNA-binding site [nucleotide binding]; DNA binding site 637381001810 UTRA domain; Region: UTRA; cl01230 637381001811 MucBP domain; Region: MucBP; pfam06458 637381001812 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 637381001813 Uncharacterized conserved protein [Function unknown]; Region: COG2966 637381001814 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 637381001815 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 637381001816 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; cl01839 637381001817 Predicted esterase [General function prediction only]; Region: COG0400 637381001818 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637381001819 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 637381001820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637381001821 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 637381001822 putative peptidoglycan binding site; other site 637381001823 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 637381001824 Bacterial SH3 domain; Region: SH3_3; cl02551 637381001825 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 637381001826 putative peptidoglycan binding site; other site 637381001827 NlpC/P60 family; Region: NLPC_P60; cl11438 637381001828 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 637381001829 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 637381001830 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381001831 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 637381001832 Domain of unknown function DUF20; Region: UPF0118; cl00465 637381001833 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 637381001834 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 637381001835 UreD urease accessory protein; Region: UreD; cl00530 637381001836 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 637381001837 DNA photolyase; Region: DNA_photolyase; pfam00875 637381001838 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 637381001839 Predicted membrane protein (DUF2177); Region: DUF2177; cl02014 637381001840 DAK2 domain; Region: Dak2; cl03685 637381001841 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 637381001842 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 637381001843 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 637381001844 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 637381001845 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637381001846 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 637381001847 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 637381001848 homodimer interface [polypeptide binding]; other site 637381001849 substrate-cofactor binding pocket; other site 637381001850 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637381001851 catalytic residue [active] 637381001852 Uncharacterized conserved protein [Function unknown]; Region: HdeD; cl01277 637381001853 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 637381001854 ligand binding site [chemical binding]; other site 637381001855 flexible hinge region; other site 637381001856 BioY family; Region: BioY; cl00560 637381001857 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381001858 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 637381001859 Uncharacterized conserved protein [Function unknown]; Region: COG3595 637381001860 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 637381001861 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637381001862 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 637381001863 MatE; Region: MatE; cl10513 637381001864 MatE; Region: MatE; cl10513 637381001865 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381001866 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637381001867 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 637381001868 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381001869 Walker A/P-loop; other site 637381001870 ATP binding site [chemical binding]; other site 637381001871 Q-loop/lid; other site 637381001872 ABC transporter signature motif; other site 637381001873 Walker B; other site 637381001874 D-loop; other site 637381001875 H-loop/switch region; other site 637381001876 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637381001877 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 637381001878 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 637381001879 Walker A/P-loop; other site 637381001880 ATP binding site [chemical binding]; other site 637381001881 Q-loop/lid; other site 637381001882 ABC transporter signature motif; other site 637381001883 Walker B; other site 637381001884 D-loop; other site 637381001885 H-loop/switch region; other site 637381001886 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 637381001887 active site residue [active] 637381001888 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637381001889 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 637381001890 Transcriptional regulators [Transcription]; Region: MarR; COG1846 637381001891 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381001892 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 637381001893 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 637381001894 putative NAD(P) binding site [chemical binding]; other site 637381001895 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637381001896 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 637381001897 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 637381001898 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 637381001899 putative active site [active] 637381001900 catalytic site [active] 637381001901 putative metal binding site [ion binding]; other site 637381001902 Catalytic domain of Protein Kinases; Region: PKc; cd00180 637381001903 active site 637381001904 ATP binding site [chemical binding]; other site 637381001905 substrate binding site [chemical binding]; other site 637381001906 activation loop (A-loop); other site 637381001907 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 637381001908 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 637381001909 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 637381001910 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 637381001911 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637381001912 Coenzyme A binding pocket [chemical binding]; other site 637381001913 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 637381001914 active site 637381001915 catalytic triad [active] 637381001916 oxyanion hole [active] 637381001917 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637381001918 domain interaction interfaces; other site 637381001919 putative Ca2+ binding sites [ion binding]; other site 637381001920 putative ligand binding motif; other site 637381001921 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cd00222 637381001922 domain interaction interfaces; other site 637381001923 putative Ca2+ binding sites [ion binding]; other site 637381001924 putative ligand binding motif; other site 637381001925 Isochorismatase family; Region: Isochorismatase; pfam00857 637381001926 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 637381001927 catalytic triad [active] 637381001928 conserved cis-peptide bond; other site 637381001929 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 637381001930 PRD domain; Region: PRD; pfam00874 637381001931 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 637381001932 P-loop; other site 637381001933 active site 637381001934 phosphorylation site [posttranslational modification] 637381001935 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637381001936 active site 637381001937 phosphorylation site [posttranslational modification] 637381001938 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637381001939 active site 637381001940 phosphorylation site [posttranslational modification] 637381001941 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637381001942 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 637381001943 P-loop; other site 637381001944 active site 637381001945 phosphorylation site [posttranslational modification] 637381001946 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 637381001947 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 637381001948 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637381001949 motif II; other site 637381001950 Rrf2 family protein; Region: rrf2_super; TIGR00738 637381001951 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381001952 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637381001953 S-adenosylmethionine binding site [chemical binding]; other site 637381001954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637381001955 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 637381001956 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 637381001957 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 637381001958 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637381001959 active site 637381001960 catalytic tetrad [active] 637381001961 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 637381001962 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 637381001963 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637381001964 motif II; other site 637381001965 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 637381001966 catalytic residue [active] 637381001967 Sulfatase; Region: Sulfatase; cl10460 637381001968 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 637381001969 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637381001970 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 637381001971 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 637381001972 putative metal binding site [ion binding]; other site 637381001973 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 637381001974 active site 637381001975 metal binding site [ion binding]; metal-binding site 637381001976 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 637381001977 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 637381001978 Transcriptional regulators [Transcription]; Region: GntR; COG1802 637381001979 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637381001980 DNA-binding site [nucleotide binding]; DNA binding site 637381001981 Predicted membrane protein [Function unknown]; Region: COG1511 637381001982 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 637381001983 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences...; Region: SPEC; cl02488 637381001984 linker region; other site 637381001985 ABC-2 type transporter; Region: ABC2_membrane; cl11417 637381001986 Transcriptional regulators [Transcription]; Region: FadR; COG2186 637381001987 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637381001988 DNA-binding site [nucleotide binding]; DNA binding site 637381001989 FCD domain; Region: FCD; cl11656 637381001990 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637381001991 Protein of unknown function (DUF975); Region: DUF975; cl10504 637381001992 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 637381001993 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 637381001994 active site 637381001995 metal binding site [ion binding]; metal-binding site 637381001996 Protein of unknown function (DUF420); Region: DUF420; cl00989 637381001997 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 637381001998 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 637381001999 minor groove reading motif; other site 637381002000 helix-hairpin-helix signature motif; other site 637381002001 substrate binding pocket [chemical binding]; other site 637381002002 active site 637381002003 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 637381002004 C-terminal domain; Region: RGG_Cterm; TIGR01716 637381002005 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 637381002006 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 637381002007 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 637381002008 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 637381002009 dimer interface [polypeptide binding]; other site 637381002010 substrate binding site [chemical binding]; other site 637381002011 ATP binding site [chemical binding]; other site 637381002012 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 637381002013 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637381002014 active site 637381002015 motif I; other site 637381002016 motif II; other site 637381002017 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637381002018 maltose O-acetyltransferase; Provisional; Region: PRK10092 637381002019 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 637381002020 active site 637381002021 substrate binding site [chemical binding]; other site 637381002022 trimer interface [polypeptide binding]; other site 637381002023 CoA binding site [chemical binding]; other site 637381002024 Protein of unknown function (DUF423); Region: DUF423; cl01008 637381002025 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 637381002026 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency...; Region: ABC_subfamily_A; cd03263 637381002027 Walker A/P-loop; other site 637381002028 ATP binding site [chemical binding]; other site 637381002029 Q-loop/lid; other site 637381002030 ABC transporter signature motif; other site 637381002031 Walker B; other site 637381002032 D-loop; other site 637381002033 H-loop/switch region; other site 637381002034 ABC-2 type transporter; Region: ABC2_membrane; cl11417 637381002035 oxidoreductase; Provisional; Region: PRK07985 637381002036 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381002037 NAD(P) binding site [chemical binding]; other site 637381002038 active site 637381002039 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; cl11557 637381002040 Protein of unknown function (DUF805); Region: DUF805; cl01224 637381002041 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 637381002042 FliP family; Region: FliP; cl00593 637381002043 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 637381002044 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 637381002045 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 637381002046 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 637381002047 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 637381002048 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 637381002049 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12726 637381002050 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 637381002051 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 637381002052 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 637381002053 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 637381002054 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 637381002055 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 637381002056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637381002057 flagellar motor protein MotA; Validated; Region: PRK08124 637381002058 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 637381002059 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 637381002060 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 637381002061 ligand binding site [chemical binding]; other site 637381002062 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 637381002063 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 637381002064 putative metal binding site [ion binding]; other site 637381002065 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 637381002066 binding surface 637381002067 TPR motif; other site 637381002068 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 637381002069 Response regulator receiver domain; Region: Response_reg; pfam00072 637381002070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637381002071 active site 637381002072 phosphorylation site [posttranslational modification] 637381002073 intermolecular recognition site; other site 637381002074 dimerization interface [polypeptide binding]; other site 637381002075 flagellin; Provisional; Region: PRK12805 637381002076 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 637381002077 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 637381002078 Response regulator receiver domain; Region: Response_reg; pfam00072 637381002079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637381002080 active site 637381002081 phosphorylation site [posttranslational modification] 637381002082 intermolecular recognition site; other site 637381002083 dimerization interface [polypeptide binding]; other site 637381002084 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 637381002085 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 637381002086 putative binding surface; other site 637381002087 active site 637381002088 P2 response regulator binding domain; Region: P2; pfam07194 637381002089 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 637381002090 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637381002091 ATP binding site [chemical binding]; other site 637381002092 Mg2+ binding site [ion binding]; other site 637381002093 G-X-G motif; other site 637381002094 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 637381002095 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 637381002096 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 637381002097 Flagellar hook capping protein; Region: FlgD; cl04347 637381002098 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 637381002099 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 637381002100 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 637381002101 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 637381002102 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 637381002103 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 637381002104 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 637381002105 flagellar motor switch protein; Reviewed; Region: PRK06782 637381002106 CheC-like family; Region: CheC; pfam04509 637381002107 CheC-like family; Region: CheC; pfam04509 637381002108 CheC-like family; Region: CheC; pfam04509 637381002109 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 637381002110 Protein of unknown function (DUF327); Region: DUF327; cl00753 637381002111 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 637381002112 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 637381002113 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 637381002114 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 637381002115 flagellar capping protein; Validated; Region: fliD; PRK06798 637381002116 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 637381002117 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 637381002118 Flagellar protein FliS; Region: FliS; cl00654 637381002119 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 637381002120 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 637381002121 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558 637381002122 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 637381002123 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 637381002124 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 637381002125 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 637381002126 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 637381002127 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 637381002128 FliG C-terminal domain; Region: FliG_C; pfam01706 637381002129 flagellar assembly protein H; Validated; Region: fliH; PRK06800 637381002130 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 637381002131 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381002132 Walker A motif; other site 637381002133 ATP binding site [chemical binding]; other site 637381002134 Walker B motif; other site 637381002135 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 637381002136 N-acetyl-D-glucosamine binding site [chemical binding]; other site 637381002137 catalytic residue [active] 637381002138 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381002139 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 637381002140 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 637381002141 pyruvate oxidase; Provisional; Region: PRK08611 637381002142 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 637381002143 PYR/PP interface [polypeptide binding]; other site 637381002144 tetramer interface [polypeptide binding]; other site 637381002145 dimer interface [polypeptide binding]; other site 637381002146 TPP binding site [chemical binding]; other site 637381002147 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 637381002148 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX...; Region: TPP_POX; cd02014 637381002149 TPP-binding site [chemical binding]; other site 637381002150 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 637381002151 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 637381002152 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 637381002153 dimerization interface [polypeptide binding]; other site 637381002154 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637381002155 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 637381002156 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 637381002157 putative active site [active] 637381002158 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 637381002159 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 637381002160 glutaminase active site [active] 637381002161 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 637381002162 dimer interface [polypeptide binding]; other site 637381002163 active site 637381002164 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 637381002165 dimer interface [polypeptide binding]; other site 637381002166 active site 637381002167 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 637381002168 active site 637381002169 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 637381002170 GIY-YIG motif/motif A; other site 637381002171 leucine-rich repeat receptor-like protein kinase; Provisional; Region: PLN00113 637381002172 MucBP domain; Region: MucBP; pfam06458 637381002173 MucBP domain; Region: MucBP; pfam06458 637381002174 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 637381002175 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637381002176 non-specific DNA binding site [nucleotide binding]; other site 637381002177 salt bridge; other site 637381002178 sequence-specific DNA binding site [nucleotide binding]; other site 637381002179 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637381002180 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637381002181 DNA binding site [nucleotide binding] 637381002182 domain linker motif; other site 637381002183 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 637381002184 ligand binding site [chemical binding]; other site 637381002185 dimerization interface [polypeptide binding]; other site 637381002186 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 637381002187 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 637381002188 substrate binding site [chemical binding]; other site 637381002189 hexamer interface [polypeptide binding]; other site 637381002190 metal binding site [ion binding]; metal-binding site 637381002191 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 637381002192 Protein of unknown function (DUF556); Region: DUF556; cl00822 637381002193 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 637381002194 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 637381002195 active site turn [active] 637381002196 phosphorylation site [posttranslational modification] 637381002197 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637381002198 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cd00210 637381002199 HPr interaction site; other site 637381002200 glycerol kinase (GK) interaction site [polypeptide binding]; other site 637381002201 active site 637381002202 phosphorylation site [posttranslational modification] 637381002203 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 637381002204 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 637381002205 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 637381002206 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 637381002207 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637381002208 DNA-binding site [nucleotide binding]; DNA binding site 637381002209 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 637381002210 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 637381002211 Walker A/P-loop; other site 637381002212 ATP binding site [chemical binding]; other site 637381002213 Q-loop/lid; other site 637381002214 ABC transporter signature motif; other site 637381002215 Walker B; other site 637381002216 D-loop; other site 637381002217 H-loop/switch region; other site 637381002218 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 637381002219 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637381002220 Walker A/P-loop; other site 637381002221 ATP binding site [chemical binding]; other site 637381002222 Q-loop/lid; other site 637381002223 ABC transporter signature motif; other site 637381002224 Walker B; other site 637381002225 D-loop; other site 637381002226 H-loop/switch region; other site 637381002227 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 637381002228 FtsX-like permease family; Region: FtsX; pfam02687 637381002229 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637381002230 non-specific DNA binding site [nucleotide binding]; other site 637381002231 salt bridge; other site 637381002232 sequence-specific DNA binding site [nucleotide binding]; other site 637381002233 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 637381002234 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 637381002235 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 637381002236 ligand binding site [chemical binding]; other site 637381002237 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381002238 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 637381002239 active site 637381002240 catalytic triad [active] 637381002241 oxyanion hole [active] 637381002242 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 637381002243 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 637381002244 Walker A/P-loop; other site 637381002245 ATP binding site [chemical binding]; other site 637381002246 Q-loop/lid; other site 637381002247 ABC transporter signature motif; other site 637381002248 Walker B; other site 637381002249 D-loop; other site 637381002250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381002251 H-loop/switch region; other site 637381002252 active site 637381002253 ABC-2 type transporter; Region: ABC2_membrane; cl11417 637381002254 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 637381002255 Zn binding site [ion binding]; other site 637381002256 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 637381002257 Zn binding site [ion binding]; other site 637381002258 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 637381002259 Zn binding site [ion binding]; other site 637381002260 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 637381002261 Zn binding site [ion binding]; other site 637381002262 Predicted esterase [General function prediction only]; Region: COG0400 637381002263 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637381002264 Flavin Reductases; Region: FlaRed; cl00801 637381002265 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 637381002266 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 637381002267 G1 box; other site 637381002268 GTP/Mg2+ binding site [chemical binding]; other site 637381002269 Switch I region; other site 637381002270 G2 box; other site 637381002271 G3 box; other site 637381002272 Switch II region; other site 637381002273 G4 box; other site 637381002274 G5 box; other site 637381002275 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 637381002276 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 637381002277 putative active site [active] 637381002278 putative metal binding site [ion binding]; other site 637381002279 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 637381002280 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 637381002281 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637381002282 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 637381002283 Uncharacterized conserved protein [Function unknown]; Region: COG3538 637381002284 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 637381002285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381002286 dimer interface [polypeptide binding]; other site 637381002287 conserved gate region; other site 637381002288 putative PBP binding loops; other site 637381002289 ABC-ATPase subunit interface; other site 637381002290 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 637381002291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381002292 dimer interface [polypeptide binding]; other site 637381002293 conserved gate region; other site 637381002294 putative PBP binding loops; other site 637381002295 ABC-ATPase subunit interface; other site 637381002296 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 637381002297 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637381002298 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 637381002299 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637381002300 DNA-binding site [nucleotide binding]; DNA binding site 637381002301 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637381002302 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 637381002303 ligand binding site [chemical binding]; other site 637381002304 dimerization interface [polypeptide binding]; other site 637381002305 Transcriptional regulators [Transcription]; Region: GntR; COG1802 637381002306 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637381002307 DNA-binding site [nucleotide binding]; DNA binding site 637381002308 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 637381002309 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 637381002310 putative NADP binding site [chemical binding]; other site 637381002311 putative dimer interface [polypeptide binding]; other site 637381002312 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 637381002313 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 637381002314 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 637381002315 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 637381002316 Protein of unknown function (DUF986); Region: DUF986; cl01983 637381002317 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 637381002318 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 637381002319 Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four...; Region: PTS_IIB_man; cd00001 637381002320 active site 637381002321 phosphorylation site [posttranslational modification] 637381002322 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006 637381002323 active pocket/dimerization site; other site 637381002324 active site 637381002325 phosphorylation site [posttranslational modification] 637381002326 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 637381002327 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637381002328 Walker A motif; other site 637381002329 ATP binding site [chemical binding]; other site 637381002330 Walker B motif; other site 637381002331 arginine finger; other site 637381002332 Transcriptional antiterminator [Transcription]; Region: COG3933 637381002333 PRD domain; Region: PRD; pfam00874 637381002334 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006 637381002335 active pocket/dimerization site; other site 637381002336 active site 637381002337 phosphorylation site [posttranslational modification] 637381002338 PRD domain; Region: PRD; pfam00874 637381002339 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 637381002340 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637381002341 Amino acid permease; Region: AA_permease; pfam00324 637381002342 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 637381002343 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 637381002344 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 637381002345 CoA enzyme activase uncharacterised domain (DUF2229); Region: DUF2229; cl12083 637381002346 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 637381002347 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 637381002348 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 637381002349 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS); Region: YbaK_deacylase; cd00002 637381002350 putative deacylase active site [active] 637381002351 Predicted membrane protein [Function unknown]; Region: COG4640 637381002352 Protein of unknown function (DUF554); Region: DUF554; cl00784 637381002353 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 637381002354 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 637381002355 NAD binding site [chemical binding]; other site 637381002356 substrate binding site [chemical binding]; other site 637381002357 putative active site [active] 637381002358 Predicted permeases [General function prediction only]; Region: RarD; COG2962 637381002359 EamA-like transporter family; Region: EamA; cl01037 637381002360 YceI-like domain; Region: YceI; cl01001 637381002361 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381002362 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637381002363 Amino acid permease; Region: AA_permease; pfam00324 637381002364 PAS domain S-box; Region: sensory_box; TIGR00229 637381002365 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 637381002366 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 637381002367 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 637381002368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 637381002369 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 637381002370 synthetase active site [active] 637381002371 NTP binding site [chemical binding]; other site 637381002372 metal binding site [ion binding]; metal-binding site 637381002373 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 637381002374 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 637381002375 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637381002376 non-specific DNA binding site [nucleotide binding]; other site 637381002377 salt bridge; other site 637381002378 sequence-specific DNA binding site [nucleotide binding]; other site 637381002379 Cupin domain; Region: Cupin_2; cl09118 637381002380 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 637381002381 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues...; Region: ABC_PotA_N; cd03300 637381002382 Walker A/P-loop; other site 637381002383 ATP binding site [chemical binding]; other site 637381002384 Q-loop/lid; other site 637381002385 ABC transporter signature motif; other site 637381002386 Walker B; other site 637381002387 D-loop; other site 637381002388 H-loop/switch region; other site 637381002389 TOBE domain; Region: TOBE_2; cl01440 637381002390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 637381002391 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 637381002392 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381002393 dimer interface [polypeptide binding]; other site 637381002394 conserved gate region; other site 637381002395 putative PBP binding loops; other site 637381002396 ABC-ATPase subunit interface; other site 637381002397 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 637381002398 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637381002399 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 637381002400 active site 637381002401 zinc binding site [ion binding]; other site 637381002402 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 637381002403 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 637381002404 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 637381002405 putative enoyl-(acyl-carrier-protein) reductase II; Region: enACPred_II; TIGR03151 637381002406 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 637381002407 FMN binding site [chemical binding]; other site 637381002408 substrate binding site [chemical binding]; other site 637381002409 putative catalytic residue [active] 637381002410 Transcriptional regulators [Transcription]; Region: MarR; COG1846 637381002411 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381002412 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637381002413 Coenzyme A binding pocket [chemical binding]; other site 637381002414 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637381002415 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 637381002416 dimer interface [polypeptide binding]; other site 637381002417 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 637381002418 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 637381002419 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 637381002420 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637381002421 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 637381002422 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 637381002423 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637381002424 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 637381002425 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 637381002426 DNA binding residues [nucleotide binding] 637381002427 putative dimer interface [polypeptide binding]; other site 637381002428 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 637381002429 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637381002430 active site 637381002431 catalytic tetrad [active] 637381002432 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 637381002433 homodimer interface [polypeptide binding]; other site 637381002434 NAD binding site [chemical binding]; other site 637381002435 catalytic residues [active] 637381002436 substrate binding pocket [chemical binding]; other site 637381002437 flexible flap; other site 637381002438 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 637381002439 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 637381002440 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 637381002441 PhoU domain; Region: PhoU; pfam01895 637381002442 PhoU domain; Region: PhoU; pfam01895 637381002443 Integrase core domain; Region: rve; cl01316 637381002444 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 637381002445 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 637381002446 dimer interface [polypeptide binding]; other site 637381002447 PYR/PP interface [polypeptide binding]; other site 637381002448 TPP binding site [chemical binding]; other site 637381002449 substrate binding site [chemical binding]; other site 637381002450 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 637381002451 Domain of unknown function; Region: EKR; cl11037 637381002452 4Fe-4S binding domain; Region: Fer4; cl02805 637381002453 TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This subfamily also includes proteins characterized as...; Region: TPP_PFOR_PNO; cd03377 637381002454 TPP-binding site [chemical binding]; other site 637381002455 dimer interface [polypeptide binding]; other site 637381002456 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 637381002457 Membrane transport protein; Region: Mem_trans; cl09117 637381002458 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 637381002459 C-terminal domain; Region: RGG_Cterm; TIGR01716 637381002460 transport protein TonB; Provisional; Region: PRK10819 637381002461 Phosphate-starvation-inducible E; Region: PsiE; cl01264 637381002462 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 637381002463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637381002464 putative substrate translocation pore; other site 637381002465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637381002466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637381002467 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637381002468 putative substrate translocation pore; other site 637381002469 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381002470 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 637381002471 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 637381002472 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 637381002473 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637381002474 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 637381002475 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 637381002476 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 637381002477 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 637381002478 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 637381002479 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 637381002480 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 637381002481 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 637381002482 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 637381002483 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 637381002484 homotrimer interaction site [polypeptide binding]; other site 637381002485 putative active site [active] 637381002486 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311 637381002487 substrate binding site [chemical binding]; other site 637381002488 zinc-binding site [ion binding]; other site 637381002489 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 637381002490 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 637381002491 GIY-YIG motif/motif A; other site 637381002492 active site 637381002493 catalytic site [active] 637381002494 putative DNA binding site [nucleotide binding]; other site 637381002495 metal binding site [ion binding]; metal-binding site 637381002496 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 637381002497 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 637381002498 substrate binding pocket [chemical binding]; other site 637381002499 membrane-bound complex binding site; other site 637381002500 hinge residues; other site 637381002501 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 637381002502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381002503 dimer interface [polypeptide binding]; other site 637381002504 conserved gate region; other site 637381002505 putative PBP binding loops; other site 637381002506 ABC-ATPase subunit interface; other site 637381002507 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 637381002508 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 637381002509 Walker A/P-loop; other site 637381002510 ATP binding site [chemical binding]; other site 637381002511 Q-loop/lid; other site 637381002512 ABC transporter signature motif; other site 637381002513 Walker B; other site 637381002514 D-loop; other site 637381002515 H-loop/switch region; other site 637381002516 amidase; Provisional; Region: PRK11910 637381002517 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 637381002518 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637381002519 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637381002520 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 637381002521 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 637381002522 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 637381002523 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 637381002524 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 637381002525 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 637381002526 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 637381002527 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637381002528 Esterase/lipase [General function prediction only]; Region: COG1647 637381002529 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 637381002530 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637381002531 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637381002532 DNA binding site [nucleotide binding] 637381002533 domain linker motif; other site 637381002534 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 637381002535 putative dimerization interface [polypeptide binding]; other site 637381002536 putative ligand binding site [chemical binding]; other site 637381002537 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 637381002538 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637381002539 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637381002540 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 637381002541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381002542 dimer interface [polypeptide binding]; other site 637381002543 conserved gate region; other site 637381002544 putative PBP binding loops; other site 637381002545 ABC-ATPase subunit interface; other site 637381002546 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 637381002547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381002548 dimer interface [polypeptide binding]; other site 637381002549 conserved gate region; other site 637381002550 ABC-ATPase subunit interface; other site 637381002551 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 637381002552 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 637381002553 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 637381002554 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 637381002555 active site 637381002556 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 637381002557 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799 637381002558 active site 637381002559 substrate binding site [chemical binding]; other site 637381002560 metal binding site [ion binding]; metal-binding site 637381002561 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 637381002562 DEAD-like helicases superfamily; Region: DEXDc; smart00487 637381002563 ATP binding site [chemical binding]; other site 637381002564 Mg++ binding site [ion binding]; other site 637381002565 motif III; other site 637381002566 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637381002567 nucleotide binding region [chemical binding]; other site 637381002568 Hef nuclease; Provisional; Region: PRK13766 637381002569 ATP-binding site [chemical binding]; other site 637381002570 QueT transporter; Region: QueT; cl01932 637381002571 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 637381002572 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 637381002573 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381002574 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 637381002575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637381002576 putative substrate translocation pore; other site 637381002577 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 637381002578 PRD domain; Region: PRD; pfam00874 637381002579 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 637381002580 P-loop; other site 637381002581 active site 637381002582 phosphorylation site [posttranslational modification] 637381002583 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637381002584 active site 637381002585 phosphorylation site [posttranslational modification] 637381002586 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 637381002587 methionine cluster; other site 637381002588 active site 637381002589 phosphorylation site [posttranslational modification] 637381002590 metal binding site [ion binding]; metal-binding site 637381002591 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564 637381002592 active site 637381002593 P-loop; other site 637381002594 phosphorylation site [posttranslational modification] 637381002595 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637381002596 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination...; Region: GlcN6P_deaminase; cd01399 637381002597 active site 637381002598 trimer interface [polypeptide binding]; other site 637381002599 allosteric site; other site 637381002600 active site lid [active] 637381002601 hexamer (dimer of trimers) interface [polypeptide binding]; other site 637381002602 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 637381002603 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 637381002604 active site 637381002605 catalytic tetrad [active] 637381002606 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 637381002607 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 637381002608 Collagen binding domain; Region: Collagen_bind; pfam05737 637381002609 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 637381002610 putative peptidoglycan binding site; other site 637381002611 Bacterial membrane flanked domain; Region: DUF304; cl01348 637381002612 Predicted membrane protein [Function unknown]; Region: COG3428 637381002613 Bacterial membrane flanked domain; Region: DUF304; cl01348 637381002614 Bacterial membrane flanked domain; Region: DUF304; cl01348 637381002615 Bacterial membrane flanked domain; Region: DUF304; cl01348 637381002616 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381002617 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 637381002618 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 637381002619 alanine racemase; Reviewed; Region: alr; PRK00053 637381002620 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 637381002621 active site 637381002622 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 637381002623 dimer interface [polypeptide binding]; other site 637381002624 substrate binding site [chemical binding]; other site 637381002625 catalytic residues [active] 637381002626 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 637381002627 PemK-like protein; Region: PemK; cl00995 637381002628 Rsbr N terminal; Region: Rsbr_N; pfam08678 637381002629 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 637381002630 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 637381002631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 637381002632 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 637381002633 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 637381002634 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 637381002635 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 637381002636 anti sigma factor interaction site; other site 637381002637 regulatory phosphorylation site [posttranslational modification]; other site 637381002638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637381002639 ATP binding site [chemical binding]; other site 637381002640 Mg2+ binding site [ion binding]; other site 637381002641 G-X-G motif; other site 637381002642 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 637381002643 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637381002644 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 637381002645 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 637381002646 DNA binding residues [nucleotide binding] 637381002647 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 637381002648 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 637381002649 Sulfate transporter family; Region: Sulfate_transp; cl00967 637381002650 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 637381002651 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 637381002652 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 637381002653 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 637381002654 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685 637381002655 RNA binding site [nucleotide binding]; other site 637381002656 hypothetical protein; Provisional; Region: PRK04351 637381002657 SprT homologues; Region: SprT; cl01182 637381002658 Protein of unknown function (DUF419); Region: DUF419; cl15265 637381002659 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637381002660 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 637381002661 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637381002662 DNA-binding site [nucleotide binding]; DNA binding site 637381002663 UTRA domain; Region: UTRA; cl01230 637381002664 OsmC-like protein; Region: OsmC; cl00767 637381002665 Protein of unknown function (DUF419); Region: DUF419; cl15265 637381002666 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 637381002667 glutathione reductase; Validated; Region: PRK06116 637381002668 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381002669 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 637381002670 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637381002671 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 637381002672 catalytic core [active] 637381002673 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 637381002674 Domain of unknown function DUF20; Region: UPF0118; cl00465 637381002675 Predicted transcriptional regulators [Transcription]; Region: COG1725 637381002676 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637381002677 DNA-binding site [nucleotide binding]; DNA binding site 637381002678 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 637381002679 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 637381002680 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 637381002681 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 637381002682 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 637381002683 tetramerization interface [polypeptide binding]; other site 637381002684 NAD(P) binding site [chemical binding]; other site 637381002685 catalytic residues [active] 637381002686 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 637381002687 P-loop; other site 637381002688 active site 637381002689 phosphorylation site [posttranslational modification] 637381002690 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637381002691 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 637381002692 methionine cluster; other site 637381002693 active site 637381002694 phosphorylation site [posttranslational modification] 637381002695 metal binding site [ion binding]; metal-binding site 637381002696 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 637381002697 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 637381002698 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 637381002699 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381002700 PRD domain; Region: PRD; pfam00874 637381002701 PRD domain; Region: PRD; pfam00874 637381002702 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637381002703 active site 637381002704 phosphorylation site [posttranslational modification] 637381002705 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 637381002706 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 637381002707 ABC transporter; Region: ABC_tran_2; pfam12848 637381002708 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 637381002709 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 637381002710 Predicted permease; Region: DUF318; cl00487 637381002711 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 637381002712 pantothenate kinase; Provisional; Region: PRK05439 637381002713 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 637381002714 ATP-binding site [chemical binding]; other site 637381002715 CoA-binding site [chemical binding]; other site 637381002716 Mg2+-binding site [ion binding]; other site 637381002717 PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 637381002718 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381002719 Walker A/P-loop; other site 637381002720 ATP binding site [chemical binding]; other site 637381002721 Q-loop/lid; other site 637381002722 ABC transporter signature motif; other site 637381002723 Walker B; other site 637381002724 D-loop; other site 637381002725 H-loop/switch region; other site 637381002726 ABC-2 type transporter; Region: ABC2_membrane; cl11417 637381002727 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637381002728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637381002729 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 637381002730 Domain of unknown function (DUF373); Region: DUF373; cl12079 637381002731 Sulfatase; Region: Sulfatase; cl10460 637381002732 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 637381002733 active site 637381002734 DNA binding site [nucleotide binding] 637381002735 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 637381002736 active site 637381002737 catalytic site [active] 637381002738 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637381002739 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 637381002740 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 637381002741 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 637381002742 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 637381002743 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 637381002744 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 637381002745 Ligand binding site [chemical binding]; other site 637381002746 Putative Catalytic site [active] 637381002747 DXD motif; other site 637381002748 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 637381002749 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 637381002750 A new structural DNA glycosylase; Region: AlkD_like; cl11434 637381002751 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 637381002752 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH...; Region: NfsA_FRP; cd02146 637381002753 dimer interface [polypeptide binding]; other site 637381002754 FMN binding site [chemical binding]; other site 637381002755 NADPH bind site [chemical binding]; other site 637381002756 Low molecular weight phosphatase family; Region: LMWPc; cd00115 637381002757 Active site [active] 637381002758 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 637381002759 HSP90 family protein; Provisional; Region: PRK14083 637381002760 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 637381002761 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 637381002762 Ferritin-like domain; Region: Ferritin; pfam00210 637381002763 dimerization interface [polypeptide binding]; other site 637381002764 DPS ferroxidase diiron center [ion binding]; other site 637381002765 ion pore; other site 637381002766 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 637381002767 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637381002768 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 637381002769 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cl11966 637381002770 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 637381002771 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 637381002772 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637381002773 putative substrate translocation pore; other site 637381002774 Transcriptional regulators [Transcription]; Region: FadR; COG2186 637381002775 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637381002776 DNA-binding site [nucleotide binding]; DNA binding site 637381002777 FCD domain; Region: FCD; cl11656 637381002778 Domain of unknown function DUF20; Region: UPF0118; cl00465 637381002779 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 637381002780 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 637381002781 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 637381002782 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 637381002783 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 637381002784 active site 637381002785 dimer interface [polypeptide binding]; other site 637381002786 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination...; Region: GlcN6P_deaminase; cd01399 637381002787 active site 637381002788 trimer interface [polypeptide binding]; other site 637381002789 allosteric site; other site 637381002790 active site lid [active] 637381002791 hexamer (dimer of trimers) interface [polypeptide binding]; other site 637381002792 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 637381002793 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637381002794 DNA-binding site [nucleotide binding]; DNA binding site 637381002795 UTRA domain; Region: UTRA; cl01230 637381002796 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 637381002797 Mg++ binding site [ion binding]; other site 637381002798 putative catalytic motif [active] 637381002799 substrate binding site [chemical binding]; other site 637381002800 Peptidase family U32; Region: Peptidase_U32; cl03113 637381002801 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 637381002802 Peptidase family U32; Region: Peptidase_U32; cl03113 637381002803 LemA family; Region: LemA; cl00742 637381002804 Peptidase family M48; Region: Peptidase_M48; cl12018 637381002805 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 637381002806 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 637381002807 catalytic residues [active] 637381002808 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 637381002809 putative active site [active] 637381002810 putative metal binding residues [ion binding]; other site 637381002811 signature motif; other site 637381002812 putative triphosphate binding site [ion binding]; other site 637381002813 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 637381002814 TPR motif; other site 637381002815 binding surface 637381002816 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 637381002817 synthetase active site [active] 637381002818 NTP binding site [chemical binding]; other site 637381002819 metal binding site [ion binding]; metal-binding site 637381002820 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 637381002821 ATP-NAD kinase; Region: NAD_kinase; pfam01513 637381002822 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 637381002823 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 637381002824 active site 637381002825 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 637381002826 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 637381002827 NAD binding site [chemical binding]; other site 637381002828 homotetramer interface [polypeptide binding]; other site 637381002829 homodimer interface [polypeptide binding]; other site 637381002830 substrate binding site [chemical binding]; other site 637381002831 active site 637381002832 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 637381002833 DltD N-terminal region; Region: DltD_N; pfam04915 637381002834 DltD central region; Region: DltD_M; pfam04918 637381002835 DltD C-terminal region; Region: DltD_C; pfam04914 637381002836 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087; cl07963 637381002837 MBOAT family; Region: MBOAT; cl00738 637381002838 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 637381002839 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 637381002840 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 637381002841 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 637381002842 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637381002843 active site 637381002844 dimer interface [polypeptide binding]; other site 637381002845 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637381002846 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637381002847 Putative esterase; Region: Esterase; pfam00756 637381002848 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 637381002849 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 637381002850 homodimer interface [polypeptide binding]; other site 637381002851 substrate-cofactor binding pocket; other site 637381002852 catalytic residue [active] 637381002853 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 637381002854 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381002855 Walker A/P-loop; other site 637381002856 ATP binding site [chemical binding]; other site 637381002857 Q-loop/lid; other site 637381002858 ABC transporter signature motif; other site 637381002859 Walker B; other site 637381002860 D-loop; other site 637381002861 H-loop/switch region; other site 637381002862 ABC-2 type transporter; Region: ABC2_membrane; cl11417 637381002863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637381002864 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637381002865 putative substrate translocation pore; other site 637381002866 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 637381002867 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 637381002868 putative oligomer interface [polypeptide binding]; other site 637381002869 putative active site [active] 637381002870 metal binding site [ion binding]; metal-binding site 637381002871 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 637381002872 catalytic residues [active] 637381002873 dimer interface [polypeptide binding]; other site 637381002874 LytTr DNA-binding domain; Region: LytTR; cl04498 637381002875 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 637381002876 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381002877 Walker A/P-loop; other site 637381002878 ATP binding site [chemical binding]; other site 637381002879 Q-loop/lid; other site 637381002880 ABC transporter signature motif; other site 637381002881 Walker B; other site 637381002882 D-loop; other site 637381002883 H-loop/switch region; other site 637381002884 ABC-2 type transporter; Region: ABC2_membrane; cl11417 637381002885 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 637381002886 RF3 subfamily. Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria. Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169 637381002887 G1 box; other site 637381002888 putative GEF interaction site [polypeptide binding]; other site 637381002889 GTP/Mg2+ binding site [chemical binding]; other site 637381002890 Switch I region; other site 637381002891 G2 box; other site 637381002892 G3 box; other site 637381002893 Switch II region; other site 637381002894 G4 box; other site 637381002895 G5 box; other site 637381002896 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 637381002897 Transcriptional regulators [Transcription]; Region: MarR; COG1846 637381002898 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381002899 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 637381002900 MatE; Region: MatE; cl10513 637381002901 Integral membrane protein TerC family; Region: TerC; cl10468 637381002902 Integral membrane protein TerC family; Region: TerC; cl10468 637381002903 Cation transport protein; Region: TrkH; cl10514 637381002904 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 637381002905 Cation transport protein; Region: TrkH; cl10514 637381002906 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 637381002907 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 637381002908 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 637381002909 DNA binding site [nucleotide binding] 637381002910 active site 637381002911 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 637381002912 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637381002913 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 637381002914 Walker A motif; other site 637381002915 ATP binding site [chemical binding]; other site 637381002916 Walker B motif; other site 637381002917 arginine finger; other site 637381002918 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 637381002919 UvrB/uvrC motif; Region: UVR; pfam02151 637381002920 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637381002921 Walker A motif; other site 637381002922 ATP binding site [chemical binding]; other site 637381002923 Walker B motif; other site 637381002924 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 637381002925 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 637381002926 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 637381002927 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381002928 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 637381002929 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 637381002930 dimerization domain swap beta strand [polypeptide binding]; other site 637381002931 regulatory protein interface [polypeptide binding]; other site 637381002932 active site 637381002933 regulatory phosphorylation site [posttranslational modification]; other site 637381002934 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 637381002935 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 637381002936 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 637381002937 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 637381002938 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 637381002939 putative active site [active] 637381002940 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 637381002941 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381002942 hypothetical protein; Validated; Region: PRK07682 637381002943 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637381002944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637381002945 homodimer interface [polypeptide binding]; other site 637381002946 catalytic residue [active] 637381002947 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 637381002948 FOG: CBS domain [General function prediction only]; Region: COG0517 637381002949 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_30; cd04643 637381002950 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637381002951 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381002952 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 637381002953 dimerization interface [polypeptide binding]; other site 637381002954 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapD_N; pfam08503 637381002955 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 637381002956 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 637381002957 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 637381002958 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 637381002959 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 637381002960 metal binding site [ion binding]; metal-binding site 637381002961 putative dimer interface [polypeptide binding]; other site 637381002962 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 637381002963 Mechanosensitive ion channel; Region: MS_channel; pfam00924 637381002964 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 637381002965 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381002966 Walker A/P-loop; other site 637381002967 ATP binding site [chemical binding]; other site 637381002968 Q-loop/lid; other site 637381002969 ABC transporter signature motif; other site 637381002970 Walker B; other site 637381002971 D-loop; other site 637381002972 H-loop/switch region; other site 637381002973 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl15354 637381002974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381002975 dimer interface [polypeptide binding]; other site 637381002976 conserved gate region; other site 637381002977 putative PBP binding loops; other site 637381002978 ABC-ATPase subunit interface; other site 637381002979 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 637381002980 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 637381002981 HPr interaction site; other site 637381002982 glycerol kinase (GK) interaction site [polypeptide binding]; other site 637381002983 active site 637381002984 phosphorylation site [posttranslational modification] 637381002985 CutC family; Region: CutC; cl01218 637381002986 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 637381002987 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 637381002988 Predicted membrane protein (DUF2154); Region: DUF2154; cl12089 637381002989 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 637381002990 Histidine kinase; Region: HisKA_3; pfam07730 637381002991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637381002992 ATP binding site [chemical binding]; other site 637381002993 Mg2+ binding site [ion binding]; other site 637381002994 G-X-G motif; other site 637381002995 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 637381002996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637381002997 active site 637381002998 phosphorylation site [posttranslational modification] 637381002999 intermolecular recognition site; other site 637381003000 dimerization interface [polypeptide binding]; other site 637381003001 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 637381003002 DNA binding residues [nucleotide binding] 637381003003 dimerization interface [polypeptide binding]; other site 637381003004 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 637381003005 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381003006 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 637381003007 Predicted membrane protein [Function unknown]; Region: COG1289 637381003008 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 637381003009 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 637381003010 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637381003011 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 637381003012 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 637381003013 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 637381003014 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637381003015 active site 637381003016 motif I; other site 637381003017 motif II; other site 637381003018 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637381003019 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637381003020 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637381003021 DNA binding site [nucleotide binding] 637381003022 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 637381003023 ligand binding site [chemical binding]; other site 637381003024 dimerization interface [polypeptide binding]; other site 637381003025 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of...; Region: L-fuc_L-ara-isomerases; cd00578 637381003026 hexamer (dimer of trimers) interface [polypeptide binding]; other site 637381003027 trimer interface [polypeptide binding]; other site 637381003028 substrate binding site [chemical binding]; other site 637381003029 Mn binding site [ion binding]; other site 637381003030 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 637381003031 TPP-binding site [chemical binding]; other site 637381003032 dimer interface [polypeptide binding]; other site 637381003033 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 637381003034 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 637381003035 PYR/PP interface [polypeptide binding]; other site 637381003036 dimer interface [polypeptide binding]; other site 637381003037 TPP binding site [chemical binding]; other site 637381003038 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637381003039 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 637381003040 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 637381003041 N- and C-terminal domain interface [polypeptide binding]; other site 637381003042 active site 637381003043 MgATP binding site [chemical binding]; other site 637381003044 catalytic site [active] 637381003045 metal binding site [ion binding]; metal-binding site 637381003046 carbohydrate binding site [chemical binding]; other site 637381003047 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 637381003048 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 637381003049 active site turn [active] 637381003050 phosphorylation site [posttranslational modification] 637381003051 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637381003052 Putative endoglucanase; Region: Glyco_hydro_101; pfam12905 637381003053 Protein of unknown function (DUF817); Region: DUF817; cl01520 637381003054 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 637381003055 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 637381003056 GTP binding site [chemical binding]; other site 637381003057 ModC is an ABC-type transporter and the ATPase component of a molybdate transport system that also includes the periplasmic binding protein ModA and the membrane protein ModB. ABC transporters are a large family of proteins involved in the transport of...; Region: ABC_ModC_molybdenum_transporter; cd03297 637381003058 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 637381003059 Walker A/P-loop; other site 637381003060 ATP binding site [chemical binding]; other site 637381003061 Q-loop/lid; other site 637381003062 ABC transporter signature motif; other site 637381003063 Walker B; other site 637381003064 D-loop; other site 637381003065 H-loop/switch region; other site 637381003066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381003067 dimer interface [polypeptide binding]; other site 637381003068 conserved gate region; other site 637381003069 putative PBP binding loops; other site 637381003070 ABC-ATPase subunit interface; other site 637381003071 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637381003072 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 637381003073 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 637381003074 dimer interface [polypeptide binding]; other site 637381003075 putative functional site; other site 637381003076 putative MPT binding site; other site 637381003077 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa...; Region: MobB; cd03116 637381003078 Walker A motif; other site 637381003079 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 637381003080 MoaE homodimer interface [polypeptide binding]; other site 637381003081 MoaD interaction [polypeptide binding]; other site 637381003082 active site residues [active] 637381003083 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 637381003084 MoaE interaction surface [polypeptide binding]; other site 637381003085 MoeB interaction surface [polypeptide binding]; other site 637381003086 thiocarboxylated glycine; other site 637381003087 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420 637381003088 trimer interface [polypeptide binding]; other site 637381003089 dimer interface [polypeptide binding]; other site 637381003090 putative active site [active] 637381003091 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 637381003092 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 637381003093 FeS/SAM binding site; other site 637381003094 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 637381003095 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 637381003096 MPT binding site; other site 637381003097 trimer interface [polypeptide binding]; other site 637381003098 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 637381003099 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 637381003100 ATP binding site [chemical binding]; other site 637381003101 substrate interface [chemical binding]; other site 637381003102 Flavin Reductases; Region: FlaRed; cl00801 637381003103 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 637381003104 active site 637381003105 catalytic residues [active] 637381003106 metal binding site [ion binding]; metal-binding site 637381003107 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 637381003108 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 637381003109 TPP-binding site [chemical binding]; other site 637381003110 tetramer interface [polypeptide binding]; other site 637381003111 heterodimer interface [polypeptide binding]; other site 637381003112 phosphorylation loop region [posttranslational modification] 637381003113 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 637381003114 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 637381003115 alpha subunit interface [polypeptide binding]; other site 637381003116 TPP binding site [chemical binding]; other site 637381003117 heterodimer interface [polypeptide binding]; other site 637381003118 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637381003119 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 637381003120 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 637381003121 E3 interaction surface; other site 637381003122 lipoyl attachment site [posttranslational modification]; other site 637381003123 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 637381003124 E3 interaction surface; other site 637381003125 lipoyl attachment site [posttranslational modification]; other site 637381003126 e3 binding domain; Region: E3_binding; pfam02817 637381003127 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 637381003128 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 637381003129 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381003130 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381003131 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 637381003132 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 637381003133 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl11406 637381003134 NAD(P) binding site [chemical binding]; other site 637381003135 LDH/MDH dimer interface [polypeptide binding]; other site 637381003136 substrate binding site [chemical binding]; other site 637381003137 Uncharacterised protein family (UPF0223); Region: UPF0223; cl11484 637381003138 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 637381003139 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637381003140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637381003141 active site 637381003142 phosphorylation site [posttranslational modification] 637381003143 intermolecular recognition site; other site 637381003144 dimerization interface [polypeptide binding]; other site 637381003145 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637381003146 DNA binding site [nucleotide binding] 637381003147 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 637381003148 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 637381003149 dimerization interface [polypeptide binding]; other site 637381003150 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637381003151 dimer interface [polypeptide binding]; other site 637381003152 phosphorylation site [posttranslational modification] 637381003153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 637381003154 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 637381003155 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 637381003156 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637381003157 Walker A/P-loop; other site 637381003158 ATP binding site [chemical binding]; other site 637381003159 Q-loop/lid; other site 637381003160 ABC transporter signature motif; other site 637381003161 Walker B; other site 637381003162 D-loop; other site 637381003163 H-loop/switch region; other site 637381003164 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 637381003165 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 637381003166 Protein of unknown function (DUF1054); Region: DUF1054; cl11544 637381003167 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1,6-; Region: IMPase_like; cd01637 637381003168 active site 637381003169 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 637381003170 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 637381003171 G1 box; other site 637381003172 putative GEF interaction site [polypeptide binding]; other site 637381003173 GTP/Mg2+ binding site [chemical binding]; other site 637381003174 Switch I region; other site 637381003175 G2 box; other site 637381003176 G3 box; other site 637381003177 Switch II region; other site 637381003178 G4 box; other site 637381003179 G5 box; other site 637381003180 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 637381003181 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 637381003182 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; cl11558 637381003183 Protein of unknown function (DUF1507); Region: DUF1507; cl11487 637381003184 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 637381003185 pyruvate carboxylase; Reviewed; Region: PRK12999 637381003186 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 637381003187 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 637381003188 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 637381003189 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 637381003190 active site 637381003191 catalytic residues [active] 637381003192 metal binding site [ion binding]; metal-binding site 637381003193 homodimer binding site [polypeptide binding]; other site 637381003194 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 637381003195 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 637381003196 carboxyltransferase (CT) interaction site; other site 637381003197 biotinylation site [posttranslational modification]; other site 637381003198 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 637381003199 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 637381003200 putative binding site residues; other site 637381003201 ABC-2 type transporter; Region: ABC2_membrane; cl11417 637381003202 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 637381003203 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 637381003204 Walker A/P-loop; other site 637381003205 ATP binding site [chemical binding]; other site 637381003206 Q-loop/lid; other site 637381003207 ABC transporter signature motif; other site 637381003208 Walker B; other site 637381003209 D-loop; other site 637381003210 H-loop/switch region; other site 637381003211 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 637381003212 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 637381003213 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 637381003214 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 637381003215 active site 637381003216 tetramer interface [polypeptide binding]; other site 637381003217 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 637381003218 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 637381003219 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 637381003220 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 637381003221 active site 637381003222 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 637381003223 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 637381003224 substrate binding site [chemical binding]; other site 637381003225 tetramer interface [polypeptide binding]; other site 637381003226 Cupin domain; Region: Cupin_2; cl09118 637381003227 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 637381003228 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 637381003229 NAD binding site [chemical binding]; other site 637381003230 substrate binding site [chemical binding]; other site 637381003231 homodimer interface [polypeptide binding]; other site 637381003232 active site 637381003233 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 637381003234 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 637381003235 NADP binding site [chemical binding]; other site 637381003236 active site 637381003237 putative substrate binding site [chemical binding]; other site 637381003238 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 637381003239 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 637381003240 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 637381003241 substrate binding site [chemical binding]; other site 637381003242 dimer interface [polypeptide binding]; other site 637381003243 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 637381003244 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 637381003245 putative NAD(P) binding site [chemical binding]; other site 637381003246 putative catalytic Zn binding site [ion binding]; other site 637381003247 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 637381003248 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 637381003249 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 637381003250 active site 637381003251 putative glycosyl transferase; Provisional; Region: PRK10073 637381003252 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 637381003253 active site 637381003254 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 637381003255 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 637381003256 active site 637381003257 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 637381003258 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_A; cd01570 637381003259 active site 637381003260 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 637381003261 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 637381003262 homodimer interface [polypeptide binding]; other site 637381003263 NAD binding pocket [chemical binding]; other site 637381003264 ATP binding pocket [chemical binding]; other site 637381003265 Mg binding site [ion binding]; other site 637381003266 active-site loop [active] 637381003267 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 637381003268 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 637381003269 P-loop; other site 637381003270 active site 637381003271 phosphorylation site [posttranslational modification] 637381003272 GMP synthase; Reviewed; Region: guaA; PRK00074 637381003273 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 637381003274 AMP/PPi binding site [chemical binding]; other site 637381003275 candidate oxyanion hole; other site 637381003276 catalytic triad [active] 637381003277 potential glutamine specificity residues [chemical binding]; other site 637381003278 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 637381003279 ATP Binding subdomain [chemical binding]; other site 637381003280 Dimerization subdomain; other site 637381003281 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 637381003282 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637381003283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637381003284 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381003285 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637381003286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421 637381003287 ATP binding site [chemical binding]; other site 637381003288 putative Mg++ binding site [ion binding]; other site 637381003289 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 637381003290 AIPR protein; Region: AIPR; pfam10592 637381003291 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637381003292 non-specific DNA binding site [nucleotide binding]; other site 637381003293 salt bridge; other site 637381003294 sequence-specific DNA binding site [nucleotide binding]; other site 637381003295 Protein of unknown function (DUF3130; Region: DUF3130; pfam11328 637381003296 Bacillus transposase protein; Region: Transposase_30; pfam04740 637381003297 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637381003298 MepB protein; Region: MepB; cl01985 637381003299 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 637381003300 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637381003301 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637381003302 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 637381003303 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 637381003304 DNA binding residues [nucleotide binding] 637381003305 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 637381003306 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 637381003307 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381003308 Walker A/P-loop; other site 637381003309 ATP binding site [chemical binding]; other site 637381003310 Q-loop/lid; other site 637381003311 ABC transporter signature motif; other site 637381003312 Walker B; other site 637381003313 D-loop; other site 637381003314 H-loop/switch region; other site 637381003315 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637381003316 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 637381003317 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381003318 Walker A/P-loop; other site 637381003319 ATP binding site [chemical binding]; other site 637381003320 Q-loop/lid; other site 637381003321 ABC transporter signature motif; other site 637381003322 Walker B; other site 637381003323 D-loop; other site 637381003324 H-loop/switch region; other site 637381003325 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 637381003326 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 637381003327 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 637381003328 DNA binding residues [nucleotide binding] 637381003329 putative dimer interface [polypeptide binding]; other site 637381003330 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 637381003331 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 637381003332 LRR adjacent; Region: LRR_adjacent; pfam08191 637381003333 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 637381003334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 637381003335 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 637381003336 oligomer interface [polypeptide binding]; other site 637381003337 active site residues [active] 637381003338 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 637381003339 dimer interface [polypeptide binding]; other site 637381003340 precorrin-2 dehydrogenase; Validated; Region: PRK06719 637381003341 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 637381003342 SLBB domain; Region: SLBB; pfam10531 637381003343 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 637381003344 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 637381003345 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 637381003346 Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 637381003347 putative hexamer interface [polypeptide binding]; other site 637381003348 putative hexagonal pore; other site 637381003349 Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 637381003350 putative hexamer interface [polypeptide binding]; other site 637381003351 putative hexagonal pore; other site 637381003352 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 637381003353 putative hexamer interface [polypeptide binding]; other site 637381003354 putative hexagonal pore; other site 637381003355 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 637381003356 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 637381003357 G3 box; other site 637381003358 Switch II region; other site 637381003359 GTP/Mg2+ binding site [chemical binding]; other site 637381003360 G4 box; other site 637381003361 G5 box; other site 637381003362 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is...; Region: CobU; cd00544 637381003363 homotrimer interface [polypeptide binding]; other site 637381003364 Walker A motif; other site 637381003365 GTP binding site [chemical binding]; other site 637381003366 Walker B motif; other site 637381003367 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 637381003368 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637381003369 catalytic core [active] 637381003370 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 637381003371 Predicted histidine kinase sensor domain; Region: Hist_Kin_Sens; pfam10114 637381003372 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637381003373 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637381003374 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637381003375 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 637381003376 Hexamer interface [polypeptide binding]; other site 637381003377 Hexagonal pore residue; other site 637381003378 propanediol utilization protein PduB; Provisional; Region: PRK15415 637381003379 Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 637381003380 putative hexamer interface [polypeptide binding]; other site 637381003381 putative hexagonal pore; other site 637381003382 Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 637381003383 putative hexamer interface [polypeptide binding]; other site 637381003384 putative hexagonal pore; other site 637381003385 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 637381003386 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1,2-...; Region: Dehydratase_LU; cd03687 637381003387 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 637381003388 alpha-beta subunit interface [polypeptide binding]; other site 637381003389 alpha-gamma subunit interface [polypeptide binding]; other site 637381003390 active site 637381003391 substrate and K+ binding site; other site 637381003392 K+ binding site [ion binding]; other site 637381003393 cobalamin binding site [chemical binding]; other site 637381003394 Dehydratase medium subunit; Region: Dehydratase_MU; cl03516 637381003395 Dehydratase small subunit; Region: Dehydratase_SU; cl02055 637381003396 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 637381003397 Dehydratase medium subunit; Region: Dehydratase_MU; cl03516 637381003398 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 637381003399 Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 637381003400 putative hexamer interface [polypeptide binding]; other site 637381003401 putative hexagonal pore; other site 637381003402 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 637381003403 Hexamer interface [polypeptide binding]; other site 637381003404 Hexagonal pore residue; other site 637381003405 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 637381003406 Propanediol utilisation protein PduL; Region: PduL; pfam06130 637381003407 Propanediol utilisation protein PduL; Region: PduL; pfam06130 637381003408 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 637381003409 Cell division protein FtsA; Region: FtsA; cl11496 637381003410 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 637381003411 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 637381003412 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 637381003413 Hexamer/Pentamer interface [polypeptide binding]; other site 637381003414 central pore; other site 637381003415 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 637381003416 Domain of unknown function (DUF336); Region: DUF336; cl01249 637381003417 aldehyde dehydrogenase EutE; Provisional; Region: PRK15398 637381003418 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 637381003419 putative catalytic cysteine [active] 637381003420 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 637381003421 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 637381003422 putative active site [active] 637381003423 metal binding site [ion binding]; metal-binding site 637381003424 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cd00333 637381003425 amphipathic channel; other site 637381003426 Asn-Pro-Ala signature motifs; other site 637381003427 Acetokinase family; Region: Acetate_kinase; cl01029 637381003428 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 637381003429 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637381003430 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637381003431 homodimer interface [polypeptide binding]; other site 637381003432 catalytic residue [active] 637381003433 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 637381003434 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 637381003435 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 637381003436 putative active site [active] 637381003437 metal binding site [ion binding]; metal-binding site 637381003438 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 637381003439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637381003440 active site 637381003441 phosphorylation site [posttranslational modification] 637381003442 intermolecular recognition site; other site 637381003443 dimerization interface [polypeptide binding]; other site 637381003444 ANTAR domain; Region: ANTAR; cl04297 637381003445 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 637381003446 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 637381003447 Histidine kinase; Region: HisKA_2; cl06527 637381003448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637381003449 ATP binding site [chemical binding]; other site 637381003450 Mg2+ binding site [ion binding]; other site 637381003451 G-X-G motif; other site 637381003452 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 637381003453 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 637381003454 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; cl09205 637381003455 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 637381003456 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 637381003457 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 637381003458 putative hexamer interface [polypeptide binding]; other site 637381003459 putative hexagonal pore; other site 637381003460 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 637381003461 putative hexamer interface [polypeptide binding]; other site 637381003462 putative hexagonal pore; other site 637381003463 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 637381003464 Hexamer interface [polypeptide binding]; other site 637381003465 Hexagonal pore residue; other site 637381003466 acetaldehyde dehydrogenase (acetylating); Region: EutH_ACDH; TIGR02518 637381003467 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 637381003468 putative catalytic cysteine [active] 637381003469 Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 637381003470 Hexamer interface [polypeptide binding]; other site 637381003471 Putative hexagonal pore residue; other site 637381003472 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 637381003473 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 637381003474 Propanediol utilisation protein PduL; Region: PduL; pfam06130 637381003475 Propanediol utilisation protein PduL; Region: PduL; pfam06130 637381003476 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 637381003477 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 637381003478 Hexamer/Pentamer interface [polypeptide binding]; other site 637381003479 central pore; other site 637381003480 ethanolamine utilization protein, PduT homolog; Region: eut_PduT; TIGR02526 637381003481 Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 637381003482 putative hexamer interface [polypeptide binding]; other site 637381003483 putative hexagonal pore; other site 637381003484 Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 637381003485 putative hexamer interface [polypeptide binding]; other site 637381003486 putative hexagonal pore; other site 637381003487 Ethanolamine utilisation protein, EutH; Region: EutH; cl01248 637381003488 Cupin domain; Region: Cupin_2; cl09118 637381003489 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 637381003490 hypothetical protein; Region: PHA01818 637381003491 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637381003492 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637381003493 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637381003494 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 637381003495 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 637381003496 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 637381003497 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 637381003498 catalytic triad [active] 637381003499 CobD/Cbib protein; Region: CobD_Cbib; cl00561 637381003500 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 637381003501 Precorrin-8X methylmutase; Region: CbiC; pfam02570 637381003502 CbiD; Region: CbiD; cl00828 637381003503 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 637381003504 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 637381003505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637381003506 S-adenosylmethionine binding site [chemical binding]; other site 637381003507 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 637381003508 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 637381003509 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 637381003510 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 637381003511 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 637381003512 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 637381003513 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 637381003514 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 637381003515 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 637381003516 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 637381003517 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 637381003518 active site 637381003519 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 637381003520 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 637381003521 active site 637381003522 C-terminal domain interface [polypeptide binding]; other site 637381003523 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 637381003524 active site 637381003525 N-terminal domain interface [polypeptide binding]; other site 637381003526 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 637381003527 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 637381003528 Cobalt transport protein component CbiN; Region: CbiN; cl00842 637381003529 Cobalt transport protein; Region: CbiQ; cl00463 637381003530 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 637381003531 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 637381003532 Walker A/P-loop; other site 637381003533 ATP binding site [chemical binding]; other site 637381003534 Q-loop/lid; other site 637381003535 ABC transporter signature motif; other site 637381003536 Walker B; other site 637381003537 D-loop; other site 637381003538 H-loop/switch region; other site 637381003539 cobyric acid synthase; Provisional; Region: PRK00784 637381003540 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 637381003541 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 637381003542 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 637381003543 catalytic triad [active] 637381003544 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 637381003545 Protein of unknown function, DUF606; Region: DUF606; cl01273 637381003546 Protein of unknown function, DUF606; Region: DUF606; cl01273 637381003547 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381003548 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381003549 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 637381003550 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 637381003551 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 637381003552 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 637381003553 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 637381003554 oligomer interface [polypeptide binding]; other site 637381003555 active site 637381003556 metal binding site [ion binding]; metal-binding site 637381003557 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 637381003558 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 637381003559 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 637381003560 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381003561 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 637381003562 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 637381003563 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 637381003564 dimer interface [polypeptide binding]; other site 637381003565 motif 1; other site 637381003566 active site 637381003567 motif 2; other site 637381003568 motif 3; other site 637381003569 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 637381003570 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 637381003571 putative tRNA-binding site [nucleotide binding]; other site 637381003572 B3/4 domain; Region: B3_4; cl11458 637381003573 tRNA synthetase B5 domain; Region: B5; cl08394 637381003574 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 637381003575 dimer interface [polypeptide binding]; other site 637381003576 motif 1; other site 637381003577 motif 3; other site 637381003578 motif 2; other site 637381003579 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 637381003580 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637381003581 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 637381003582 Walker A/P-loop; other site 637381003583 ATP binding site [chemical binding]; other site 637381003584 Q-loop/lid; other site 637381003585 ABC transporter signature motif; other site 637381003586 Walker B; other site 637381003587 D-loop; other site 637381003588 H-loop/switch region; other site 637381003589 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 637381003590 FtsX-like permease family; Region: FtsX; pfam02687 637381003591 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 637381003592 FtsX-like permease family; Region: FtsX; pfam02687 637381003593 Transcriptional regulators [Transcription]; Region: MarR; COG1846 637381003594 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381003595 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 637381003596 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 637381003597 ligand binding site [chemical binding]; other site 637381003598 active site 637381003599 UGI interface [polypeptide binding]; other site 637381003600 catalytic site [active] 637381003601 ribonuclease HIII; Provisional; Region: PRK00996 637381003602 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 637381003603 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 637381003604 RNA/DNA hybrid binding site [nucleotide binding]; other site 637381003605 active site 637381003606 Cell division protein ZapA; Region: ZapA; cl01146 637381003607 Colicin V production protein; Region: Colicin_V; cl00567 637381003608 hypothetical protein; Provisional; Region: PRK08609 637381003609 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 637381003610 active site 637381003611 primer binding site [nucleotide binding]; other site 637381003612 NTP binding site [chemical binding]; other site 637381003613 metal binding triad [ion binding]; metal-binding site 637381003614 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 637381003615 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 637381003616 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381003617 Walker A/P-loop; other site 637381003618 ATP binding site [chemical binding]; other site 637381003619 Q-loop/lid; other site 637381003620 ABC transporter signature motif; other site 637381003621 Walker B; other site 637381003622 D-loop; other site 637381003623 H-loop/switch region; other site 637381003624 Smr domain; Region: Smr; cl02619 637381003625 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 637381003626 catalytic residues [active] 637381003627 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 637381003628 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 637381003629 GIY-YIG motif/motif A; other site 637381003630 active site 637381003631 catalytic site [active] 637381003632 putative DNA binding site [nucleotide binding]; other site 637381003633 metal binding site [ion binding]; metal-binding site 637381003634 UvrB/uvrC motif; Region: UVR; pfam02151 637381003635 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 637381003636 aspartate kinase; Reviewed; Region: PRK06635 637381003637 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 637381003638 putative nucleotide binding site [chemical binding]; other site 637381003639 putative catalytic residues [active] 637381003640 putative Mg ion binding site [ion binding]; other site 637381003641 putative aspartate binding site [chemical binding]; other site 637381003642 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 637381003643 putative allosteric regulatory site; other site 637381003644 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 637381003645 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 637381003646 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 637381003647 ribonuclease PH; Reviewed; Region: rph; PRK00173 637381003648 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 637381003649 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 637381003650 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 637381003651 active site 637381003652 dimerization interface [polypeptide binding]; other site 637381003653 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 637381003654 active site 637381003655 metal binding site [ion binding]; metal-binding site 637381003656 homotetramer interface [polypeptide binding]; other site 637381003657 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 637381003658 Phage integrase family; Region: Phage_integrase; pfam00589 637381003659 Int/Topo IB signature motif; other site 637381003660 Telomeric repeat-binding factor 2; Region: TRF2; pfam11611 637381003661 Domain of unknown function (DUF955); Region: DUF955; cl01076 637381003662 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 637381003663 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 637381003664 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 637381003665 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 637381003666 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637381003667 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 637381003668 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 637381003669 Phage integrase family; Region: Phage_integrase; pfam00589 637381003670 Int/Topo IB signature motif; other site 637381003671 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 637381003672 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 637381003673 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 637381003674 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381003675 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637381003676 nucleotide binding region [chemical binding]; other site 637381003677 ATP-binding site [chemical binding]; other site 637381003678 Uncharacterised protein family UPF0547; Region: UPF0547; pfam10571 637381003679 Protein of unknown function (DUF669); Region: DUF669; pfam05037 637381003680 Uncharacterized conserved protein [Function unknown]; Region: COG4983 637381003681 D5 N terminal like; Region: D5_N; cl07360 637381003682 C-terminal domain; Region: primase_Cterm; TIGR01613 637381003683 VRR-NUC domain; Region: VRR_NUC; cl08494 637381003684 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 637381003685 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 637381003686 Protein of unknown function (DUF722); Region: DUF722; pfam05263 637381003687 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 637381003688 putative active site [active] 637381003689 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 637381003690 Phage terminase, small subunit; Region: Terminase_4; cl01525 637381003691 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 637381003692 Phage Terminase; Region: Terminase_1; pfam03354 637381003693 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 637381003694 Phage portal protein; Region: Phage_portal; pfam04860 637381003695 Phage-related protein [Function unknown]; Region: COG4695; cl01923 637381003696 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 637381003697 oligomer interface [polypeptide binding]; other site 637381003698 active site residues [active] 637381003699 Phage capsid family; Region: Phage_capsid; pfam05065 637381003700 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 637381003701 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 637381003702 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 637381003703 Phage tail protein; Region: Sipho_tail; cl11462 637381003704 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 637381003705 Bacteriophage holin; Region: Phage_holin_1; cl02344 637381003706 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 637381003707 Uncharacterized conserved protein [Function unknown]; Region: COG5361 637381003708 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 637381003709 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 637381003710 Protein of unknown function (DUF419); Region: DUF419; cl15265 637381003711 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 637381003712 dimer interface [polypeptide binding]; other site 637381003713 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637381003714 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 637381003715 catalytic core [active] 637381003716 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 637381003717 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 637381003718 ATP binding site [chemical binding]; other site 637381003719 Mg++ binding site [ion binding]; other site 637381003720 motif III; other site 637381003721 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637381003722 nucleotide binding region [chemical binding]; other site 637381003723 ATP-binding site [chemical binding]; other site 637381003724 DbpA RNA binding domain; Region: DbpA; pfam03880 637381003725 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 637381003726 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 637381003727 putative active site [active] 637381003728 nucleotide binding site [chemical binding]; other site 637381003729 nudix motif; other site 637381003730 putative metal binding site [ion binding]; other site 637381003731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637381003732 putative substrate translocation pore; other site 637381003733 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 637381003734 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381003735 Uncharacterized conserved protein [Function unknown]; Region: COG1284 637381003736 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 637381003737 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 637381003738 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 637381003739 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637381003740 DNA-binding site [nucleotide binding]; DNA binding site 637381003741 UTRA domain; Region: UTRA; cl01230 637381003742 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 637381003743 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 637381003744 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 637381003745 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 637381003746 active site turn [active] 637381003747 phosphorylation site [posttranslational modification] 637381003748 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637381003749 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 637381003750 nudix motif; other site 637381003751 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 637381003752 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637381003753 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 637381003754 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 637381003755 putative catalytic cysteine [active] 637381003756 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 637381003757 nucleotide binding site [chemical binding]; other site 637381003758 homotetrameric interface [polypeptide binding]; other site 637381003759 putative phosphate binding site [ion binding]; other site 637381003760 putative allosteric binding site; other site 637381003761 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 637381003762 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 637381003763 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637381003764 non-specific DNA binding site [nucleotide binding]; other site 637381003765 salt bridge; other site 637381003766 sequence-specific DNA binding site [nucleotide binding]; other site 637381003767 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 637381003768 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...; Region: ZnMc; cl00064 637381003769 active site 637381003770 trigger factor; Provisional; Region: tig; PRK01490 637381003771 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 637381003772 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 637381003773 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 637381003774 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 637381003775 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637381003776 Walker A motif; other site 637381003777 ATP binding site [chemical binding]; other site 637381003778 Walker B motif; other site 637381003779 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 637381003780 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 637381003781 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 637381003782 Catalytic site [active] 637381003783 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 637381003784 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 637381003785 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 637381003786 Catalytic site [active] 637381003787 Peptidase S26; Region: Peptidase_S26; pfam10502 637381003788 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 637381003789 Catalytic site [active] 637381003790 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 637381003791 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 637381003792 YlqF. Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases...; Region: YlqF; cd01856 637381003793 GTP/Mg2+ binding site [chemical binding]; other site 637381003794 G4 box; other site 637381003795 G5 box; other site 637381003796 G1 box; other site 637381003797 Switch I region; other site 637381003798 G2 box; other site 637381003799 G3 box; other site 637381003800 Switch II region; other site 637381003801 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 637381003802 RNA/DNA hybrid binding site [nucleotide binding]; other site 637381003803 active site 637381003804 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 637381003805 DNA topoisomerase I; Validated; Region: PRK05582 637381003806 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 637381003807 active site 637381003808 interdomain interaction site; other site 637381003809 putative metal-binding site [ion binding]; other site 637381003810 nucleotide binding site [chemical binding]; other site 637381003811 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 637381003812 domain I; other site 637381003813 DNA binding groove [nucleotide binding] 637381003814 phosphate binding site [ion binding]; other site 637381003815 domain II; other site 637381003816 domain III; other site 637381003817 nucleotide binding site [chemical binding]; other site 637381003818 catalytic site [active] 637381003819 domain IV; other site 637381003820 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 637381003821 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 637381003822 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381003823 Glucose inhibited division protein A; Region: GIDA; pfam01134 637381003824 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 637381003825 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 637381003826 DNA binding site [nucleotide binding] 637381003827 Int/Topo IB signature motif; other site 637381003828 active site 637381003829 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 637381003830 active site 637381003831 HslU subunit interaction site [polypeptide binding]; other site 637381003832 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 637381003833 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637381003834 Walker A motif; other site 637381003835 ATP binding site [chemical binding]; other site 637381003836 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381003837 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 637381003838 transcriptional repressor CodY; Validated; Region: PRK04158 637381003839 CodY GAF-like domain; Region: CodY; pfam06018 637381003840 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 637381003841 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 637381003842 active site 637381003843 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 637381003844 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 637381003845 active site 637381003846 catalytic residues [active] 637381003847 Domain of unknown function (DUF205); Region: DUF205; cl00410 637381003848 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381003849 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 637381003850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 637381003851 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 637381003852 anchoring element; other site 637381003853 dimer interface [polypeptide binding]; other site 637381003854 ATP binding site [chemical binding]; other site 637381003855 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 637381003856 active site 637381003857 putative metal-binding site [ion binding]; other site 637381003858 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 637381003859 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 637381003860 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 637381003861 CAP-like domain; other site 637381003862 Active site [active] 637381003863 primary dimer interface [polypeptide binding]; other site 637381003864 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637381003865 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 637381003866 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637381003867 putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK05641 637381003868 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 637381003869 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 637381003870 catalytic triad [active] 637381003871 catalytic triad [active] 637381003872 oxyanion hole [active] 637381003873 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 637381003874 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 637381003875 active site 637381003876 catalytic site [active] 637381003877 metal binding site [ion binding]; metal-binding site 637381003878 dimer interface [polypeptide binding]; other site 637381003879 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 637381003880 IPP transferase; Region: IPPT; cl00403 637381003881 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 637381003882 Sm1 motif; other site 637381003883 D3 - B interaction site; other site 637381003884 D1 - D2 interaction site; other site 637381003885 Hfq - Hfq interaction site; other site 637381003886 RNA binding pocket [nucleotide binding]; other site 637381003887 Sm2 motif; other site 637381003888 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 637381003889 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 637381003890 G1 box; other site 637381003891 GTP/Mg2+ binding site [chemical binding]; other site 637381003892 Switch I region; other site 637381003893 G2 box; other site 637381003894 G3 box; other site 637381003895 Switch II region; other site 637381003896 G4 box; other site 637381003897 G5 box; other site 637381003898 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 637381003899 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 637381003900 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 637381003901 DNA binding residues [nucleotide binding] 637381003902 putative dimer interface [polypeptide binding]; other site 637381003903 glutamine synthetase, type I; Region: GlnA; TIGR00653 637381003904 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 637381003905 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 637381003906 arsenical pump membrane protein; Provisional; Region: PRK15445 637381003907 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 637381003908 transmembrane helices; other site 637381003909 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637381003910 LexA repressor; Validated; Region: PRK00215 637381003911 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381003912 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 637381003913 Catalytic site [active] 637381003914 cell division suppressor protein YneA; Provisional; Region: PRK14125 637381003915 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 637381003916 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 637381003917 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 637381003918 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 637381003919 TPP-binding site [chemical binding]; other site 637381003920 dimer interface [polypeptide binding]; other site 637381003921 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 637381003922 PYR/PP interface [polypeptide binding]; other site 637381003923 dimer interface [polypeptide binding]; other site 637381003924 TPP binding site [chemical binding]; other site 637381003925 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637381003926 Uncharacterised protein family (UPF0154); Region: UPF0154; cl01536 637381003927 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 637381003928 ParB-like nuclease domain; Region: ParBc; cl02129 637381003929 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 637381003930 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 637381003931 Active Sites [active] 637381003932 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 637381003933 DEAD-like helicases superfamily; Region: DEXDc; smart00487 637381003934 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 637381003935 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 637381003936 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 637381003937 putative nucleotide binding site [chemical binding]; other site 637381003938 uridine monophosphate binding site [chemical binding]; other site 637381003939 homohexameric interface [polypeptide binding]; other site 637381003940 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 637381003941 hinge region; other site 637381003942 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 637381003943 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 637381003944 catalytic residue [active] 637381003945 putative FPP diphosphate binding site; other site 637381003946 putative FPP binding hydrophobic cleft; other site 637381003947 dimer interface [polypeptide binding]; other site 637381003948 putative IPP diphosphate binding site; other site 637381003949 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 637381003950 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 637381003951 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 637381003952 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 637381003953 RIP metalloprotease RseP; Region: TIGR00054 637381003954 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 637381003955 active site 637381003956 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 637381003957 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 637381003958 protein binding site [polypeptide binding]; other site 637381003959 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 637381003960 putative substrate binding region [chemical binding]; other site 637381003961 prolyl-tRNA synthetase; Provisional; Region: PRK09194 637381003962 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 637381003963 dimer interface [polypeptide binding]; other site 637381003964 motif 1; other site 637381003965 active site 637381003966 motif 2; other site 637381003967 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 637381003968 putative deacylase active site [active] 637381003969 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 637381003970 active site 637381003971 motif 3; other site 637381003972 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 637381003973 anticodon binding site; other site 637381003974 DNA polymerase III PolC; Validated; Region: polC; PRK00448 637381003975 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 637381003976 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 637381003977 generic binding surface II; other site 637381003978 generic binding surface I; other site 637381003979 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 637381003980 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 637381003981 active site 637381003982 substrate binding site [chemical binding]; other site 637381003983 catalytic site [active] 637381003984 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 637381003985 ribosome maturation protein RimP; Reviewed; Region: PRK00092 637381003986 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 637381003987 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 637381003988 Sm1 motif; other site 637381003989 predicted subunit interaction site [polypeptide binding]; other site 637381003990 RNA binding pocket [nucleotide binding]; other site 637381003991 Sm2 motif; other site 637381003992 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 637381003993 NusA N-terminal domain; Region: NusA_N; pfam08529 637381003994 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 637381003995 RNA binding site [nucleotide binding]; other site 637381003996 homodimer interface [polypeptide binding]; other site 637381003997 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 637381003998 G-X-X-G motif; other site 637381003999 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 637381004000 putative RNA binding cleft [nucleotide binding]; other site 637381004001 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 637381004002 translation initiation factor IF-2; Validated; Region: infB; PRK05306 637381004003 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 637381004004 translation initiation factor IF-2; Region: IF-2; TIGR00487 637381004005 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 637381004006 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 637381004007 G1 box; other site 637381004008 putative GEF interaction site [polypeptide binding]; other site 637381004009 GTP/Mg2+ binding site [chemical binding]; other site 637381004010 Switch I region; other site 637381004011 G2 box; other site 637381004012 G3 box; other site 637381004013 Switch II region; other site 637381004014 G4 box; other site 637381004015 G5 box; other site 637381004016 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 637381004017 Translation-initiation factor 2; Region: IF-2; pfam11987 637381004018 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 637381004019 Protein of unknown function (DUF503); Region: DUF503; cl00669 637381004020 Ribosome-binding factor A; Region: RBFA; cl00542 637381004021 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 637381004022 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 637381004023 RNA binding site [nucleotide binding]; other site 637381004024 active site 637381004025 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 637381004026 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 637381004027 active site 637381004028 Riboflavin kinase; Region: Flavokinase; cl03312 637381004029 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 637381004030 16S/18S rRNA binding site [nucleotide binding]; other site 637381004031 S13e-L30e interaction site [polypeptide binding]; other site 637381004032 25S rRNA binding site [nucleotide binding]; other site 637381004033 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 637381004034 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 637381004035 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 637381004036 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 637381004037 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 637381004038 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 637381004039 putative nucleic acid binding region [nucleotide binding]; other site 637381004040 G-X-X-G motif; other site 637381004041 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 637381004042 RNA binding site [nucleotide binding]; other site 637381004043 domain interface; other site 637381004044 GTPase RsgA; Reviewed; Region: PRK01889 637381004045 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 637381004046 GTPase/OB domain interface [polypeptide binding]; other site 637381004047 GTPase/Zn-binding domain interface [polypeptide binding]; other site 637381004048 GTP/Mg2+ binding site [chemical binding]; other site 637381004049 G4 box; other site 637381004050 G5 box; other site 637381004051 G1 box; other site 637381004052 Switch I region; other site 637381004053 G2 box; other site 637381004054 G3 box; other site 637381004055 Switch II region; other site 637381004056 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 637381004057 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 637381004058 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 637381004059 intramembrane serine protease GlpG; Provisional; Region: PRK10907 637381004060 Rhomboid family; Region: Rhomboid; cl11446 637381004061 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 637381004062 TPR motif; other site 637381004063 binding surface 637381004064 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 637381004065 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 637381004066 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 637381004067 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 637381004068 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 637381004069 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 637381004070 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 637381004071 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 637381004072 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381004073 Walker A motif; other site 637381004074 ATP binding site [chemical binding]; other site 637381004075 Walker B motif; other site 637381004076 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 637381004077 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 637381004078 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 637381004079 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 637381004080 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 637381004081 tetramer interface [polypeptide binding]; other site 637381004082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637381004083 catalytic residue [active] 637381004084 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 637381004085 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 637381004086 tetramer interface [polypeptide binding]; other site 637381004087 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637381004088 catalytic residue [active] 637381004089 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 637381004090 active site residue [active] 637381004091 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 637381004092 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 637381004093 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 637381004094 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 637381004095 active site 637381004096 elongation factor P; Validated; Region: PRK00529 637381004097 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 637381004098 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 637381004099 RNA binding site [nucleotide binding]; other site 637381004100 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 637381004101 RNA binding site [nucleotide binding]; other site 637381004102 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 637381004103 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 637381004104 carboxyltransferase (CT) interaction site; other site 637381004105 biotinylation site [posttranslational modification]; other site 637381004106 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 637381004107 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 637381004108 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 637381004109 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 637381004110 Protein of unknown function (DUF322); Region: DUF322; cl00574 637381004111 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 637381004112 putative RNA binding site [nucleotide binding]; other site 637381004113 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14170 637381004114 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 637381004115 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 637381004116 homodimer interface [polypeptide binding]; other site 637381004117 NADP binding site [chemical binding]; other site 637381004118 substrate binding site [chemical binding]; other site 637381004119 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 637381004120 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 637381004121 generic binding surface II; other site 637381004122 generic binding surface I; other site 637381004123 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 637381004124 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 637381004125 substrate binding pocket [chemical binding]; other site 637381004126 chain length determination region; other site 637381004127 substrate-Mg2+ binding site; other site 637381004128 catalytic residues [active] 637381004129 aspartate-rich region 1; other site 637381004130 active site lid residues [active] 637381004131 aspartate-rich region 2; other site 637381004132 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 637381004133 DNA-binding site [nucleotide binding]; DNA binding site 637381004134 RNA-binding motif; other site 637381004135 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 637381004136 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 637381004137 TPP-binding site; other site 637381004138 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 637381004139 PYR/PP interface [polypeptide binding]; other site 637381004140 dimer interface [polypeptide binding]; other site 637381004141 TPP binding site [chemical binding]; other site 637381004142 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637381004143 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 637381004144 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 637381004145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637381004146 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 637381004147 arginine repressor; Provisional; Region: PRK04280 637381004148 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 637381004149 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 637381004150 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 637381004151 Walker A/P-loop; other site 637381004152 ATP binding site [chemical binding]; other site 637381004153 Q-loop/lid; other site 637381004154 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 637381004155 ABC transporter signature motif; other site 637381004156 Walker B; other site 637381004157 D-loop; other site 637381004158 H-loop/switch region; other site 637381004159 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 637381004160 Acetokinase family; Region: Acetate_kinase; cl01029 637381004161 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 637381004162 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381004163 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 637381004164 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 637381004165 tetramer interface [polypeptide binding]; other site 637381004166 TPP-binding site [chemical binding]; other site 637381004167 heterodimer interface [polypeptide binding]; other site 637381004168 phosphorylation loop region [posttranslational modification] 637381004169 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 637381004170 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 637381004171 alpha subunit interface [polypeptide binding]; other site 637381004172 TPP binding site [chemical binding]; other site 637381004173 heterodimer interface [polypeptide binding]; other site 637381004174 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637381004175 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 637381004176 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 637381004177 E3 interaction surface; other site 637381004178 lipoyl attachment site [posttranslational modification]; other site 637381004179 e3 binding domain; Region: E3_binding; pfam02817 637381004180 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 637381004181 peptidase T-like protein; Region: PepT-like; TIGR01883 637381004182 M28, and M42; Region: Zinc_peptidase_like; cl14876 637381004183 metal binding site [ion binding]; metal-binding site 637381004184 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381004185 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 637381004186 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 637381004187 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637381004188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637381004189 active site 637381004190 phosphorylation site [posttranslational modification] 637381004191 intermolecular recognition site; other site 637381004192 dimerization interface [polypeptide binding]; other site 637381004193 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637381004194 DNA binding site [nucleotide binding] 637381004195 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 637381004196 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 637381004197 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637381004198 dimer interface [polypeptide binding]; other site 637381004199 phosphorylation site [posttranslational modification] 637381004200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637381004201 ATP binding site [chemical binding]; other site 637381004202 Mg2+ binding site [ion binding]; other site 637381004203 G-X-G motif; other site 637381004204 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 637381004205 Acylphosphatase; Region: Acylphosphatase; cl00551 637381004206 Protein of unknown function (DUF1033); Region: DUF1033; cl11549 637381004207 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 637381004208 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal...; Region: IDI-2_FMN; cd02811 637381004209 homotetramer interface [polypeptide binding]; other site 637381004210 FMN binding site [chemical binding]; other site 637381004211 homodimer contacts [polypeptide binding]; other site 637381004212 putative active site [active] 637381004213 putative substrate binding site [chemical binding]; other site 637381004214 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 637381004215 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 637381004216 active site residue [active] 637381004217 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 637381004218 Uncharacterized conserved protein [Function unknown]; Region: COG1284 637381004219 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 637381004220 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 637381004221 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381004222 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 637381004223 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381004224 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 637381004225 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 637381004226 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 637381004227 ligand binding site [chemical binding]; other site 637381004228 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 637381004229 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 637381004230 Walker A/P-loop; other site 637381004231 ATP binding site [chemical binding]; other site 637381004232 Q-loop/lid; other site 637381004233 ABC transporter signature motif; other site 637381004234 Walker B; other site 637381004235 D-loop; other site 637381004236 H-loop/switch region; other site 637381004237 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 637381004238 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 637381004239 TM-ABC transporter signature motif; other site 637381004240 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 637381004241 TM-ABC transporter signature motif; other site 637381004242 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 637381004243 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 637381004244 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 637381004245 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 637381004246 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 637381004247 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 637381004248 classical (c) SDRs; Region: SDR_c; cd05233 637381004249 NAD(P) binding site [chemical binding]; other site 637381004250 active site 637381004251 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 637381004252 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 637381004253 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 637381004254 competence damage-inducible protein A; Provisional; Region: PRK00549 637381004255 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 637381004256 putative MPT binding site; other site 637381004257 Competence-damaged protein; Region: CinA; cl00666 637381004258 recombinase A; Provisional; Region: recA; PRK09354 637381004259 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 637381004260 hexamer interface [polypeptide binding]; other site 637381004261 Walker A motif; other site 637381004262 ATP binding site [chemical binding]; other site 637381004263 Walker B motif; other site 637381004264 phosphodiesterase; Provisional; Region: PRK12704 637381004265 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 637381004266 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 637381004267 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637381004268 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 637381004269 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 637381004270 putative active site [active] 637381004271 metal binding site [ion binding]; metal-binding site 637381004272 homodimer binding site [polypeptide binding]; other site 637381004273 Protein of unknown function (DUF964); Region: DUF964; cl01483 637381004274 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 637381004275 MutS domain I; Region: MutS_I; pfam01624 637381004276 MutS domain II; Region: MutS_II; pfam05188 637381004277 MutS family domain IV; Region: MutS_IV; pfam05190 637381004278 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 637381004279 Walker A/P-loop; other site 637381004280 ATP binding site [chemical binding]; other site 637381004281 Q-loop/lid; other site 637381004282 ABC transporter signature motif; other site 637381004283 Walker B; other site 637381004284 D-loop; other site 637381004285 H-loop/switch region; other site 637381004286 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 637381004287 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637381004288 ATP binding site [chemical binding]; other site 637381004289 Mg2+ binding site [ion binding]; other site 637381004290 G-X-G motif; other site 637381004291 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 637381004292 ATP binding site [chemical binding]; other site 637381004293 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 637381004294 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 637381004295 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 637381004296 Pyruvate formate lyase 1; Region: PFL1; cd01678 637381004297 coenzyme A binding site [chemical binding]; other site 637381004298 active site 637381004299 catalytic residues [active] 637381004300 glycine loop; other site 637381004301 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 637381004302 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 637381004303 FeS/SAM binding site; other site 637381004304 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381004305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637381004306 putative substrate translocation pore; other site 637381004307 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 637381004308 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 637381004309 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381004310 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 637381004311 putative acyltransferase; Provisional; Region: PRK05790 637381004312 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 637381004313 dimer interface [polypeptide binding]; other site 637381004314 active site 637381004315 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by...; Region: init_cond_enzymes; cd00827 637381004316 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 637381004317 dimer interface [polypeptide binding]; other site 637381004318 active site 637381004319 VanZ like family; Region: VanZ; cl01971 637381004320 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 637381004321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637381004322 putative substrate translocation pore; other site 637381004323 Uncharacterized conserved protein [Function unknown]; Region: COG3379 637381004324 Sulfatase; Region: Sulfatase; cl10460 637381004325 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 637381004326 Domain of unknown function DUF20; Region: UPF0118; cl00465 637381004327 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 637381004328 FAD binding domain; Region: FAD_binding_4; pfam01565 637381004329 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 637381004330 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 637381004331 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family...; Region: ABC_OpuCA_Osmoprotection; cd03295 637381004332 Walker A/P-loop; other site 637381004333 ATP binding site [chemical binding]; other site 637381004334 Q-loop/lid; other site 637381004335 ABC transporter signature motif; other site 637381004336 Walker B; other site 637381004337 D-loop; other site 637381004338 H-loop/switch region; other site 637381004339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381004340 dimer interface [polypeptide binding]; other site 637381004341 conserved gate region; other site 637381004342 ABC-ATPase subunit interface; other site 637381004343 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 637381004344 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 637381004345 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 637381004346 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 637381004347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381004348 dimer interface [polypeptide binding]; other site 637381004349 conserved gate region; other site 637381004350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 637381004351 ABC-ATPase subunit interface; other site 637381004352 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 637381004353 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 637381004354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381004355 dimer interface [polypeptide binding]; other site 637381004356 conserved gate region; other site 637381004357 putative PBP binding loops; other site 637381004358 ABC-ATPase subunit interface; other site 637381004359 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family...; Region: ABC_OpuCA_Osmoprotection; cd03295 637381004360 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 637381004361 Walker A/P-loop; other site 637381004362 ATP binding site [chemical binding]; other site 637381004363 Q-loop/lid; other site 637381004364 ABC transporter signature motif; other site 637381004365 Walker B; other site 637381004366 D-loop; other site 637381004367 H-loop/switch region; other site 637381004368 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 637381004369 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 637381004370 Protein of unknown function (DUF419); Region: DUF419; cl15265 637381004371 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 637381004372 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 637381004373 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381004374 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 637381004375 ABC transporter; Region: ABC_tran_2; pfam12848 637381004376 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 637381004377 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 637381004378 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381004379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381004380 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 637381004381 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 637381004382 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637381004383 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 637381004384 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 637381004385 dihydrodipicolinate synthase; Region: dapA; TIGR00674 637381004386 dimer interface [polypeptide binding]; other site 637381004387 active site 637381004388 catalytic residue [active] 637381004389 aspartate kinase I; Reviewed; Region: PRK08210 637381004390 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 637381004391 nucleotide binding site [chemical binding]; other site 637381004392 substrate binding site [chemical binding]; other site 637381004393 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 637381004394 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 637381004395 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 637381004396 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381004397 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 637381004398 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 637381004399 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 637381004400 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 637381004401 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 637381004402 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 637381004403 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 637381004404 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 637381004405 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 637381004406 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 637381004407 AzlC protein; Region: AzlC; cl00570 637381004408 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 637381004409 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 637381004410 PPIC-type PPIASE domain; Region: Rotamase; cl08278 637381004411 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 637381004412 metal binding site 2 [ion binding]; metal-binding site 637381004413 putative DNA binding helix; other site 637381004414 metal binding site 1 [ion binding]; metal-binding site 637381004415 dimer interface [polypeptide binding]; other site 637381004416 structural Zn2+ binding site [ion binding]; other site 637381004417 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 637381004418 ABC-ATPase subunit interface; other site 637381004419 dimer interface [polypeptide binding]; other site 637381004420 putative PBP binding regions; other site 637381004421 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 637381004422 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 637381004423 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 637381004424 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl15354 637381004425 DHHA2 domain; Region: DHHA2; pfam02833 637381004426 endonuclease IV; Provisional; Region: PRK01060 637381004427 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cd00019 637381004428 AP (apurinic/apyrimidinic) site pocket; other site 637381004429 DNA interaction; other site 637381004430 Metal-binding active site; metal-binding site 637381004431 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 637381004432 DEAD-like helicases superfamily; Region: DEXDc; smart00487 637381004433 ATP binding site [chemical binding]; other site 637381004434 Mg++ binding site [ion binding]; other site 637381004435 motif III; other site 637381004436 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637381004437 nucleotide binding region [chemical binding]; other site 637381004438 ATP-binding site [chemical binding]; other site 637381004439 LytB protein; Region: LYTB; cl00507 637381004440 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 637381004441 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 637381004442 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 637381004443 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 637381004444 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637381004445 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 637381004446 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 637381004447 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 637381004448 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637381004449 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 637381004450 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 637381004451 DNA binding residues [nucleotide binding] 637381004452 DNA primase; Validated; Region: dnaG; PRK05667 637381004453 CHC2 zinc finger; Region: zf-CHC2; cl02597 637381004454 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 637381004455 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 637381004456 active site 637381004457 metal binding site [ion binding]; metal-binding site 637381004458 interdomain interaction site; other site 637381004459 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 637381004460 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 637381004461 Domain of unknown function (DUF299); Region: DUF299; cl00780 637381004462 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 637381004463 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 637381004464 glycyl-tRNA synthetase, tetrameric type, alpha subunit; Region: glyQ; TIGR00388 637381004465 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 637381004466 dimer interface [polypeptide binding]; other site 637381004467 motif 1; other site 637381004468 active site 637381004469 motif 2; other site 637381004470 motif 3; other site 637381004471 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 637381004472 Recombination protein O N terminal; Region: RecO_N; pfam11967 637381004473 Recombination protein O C terminal; Region: RecO_C; pfam02565 637381004474 Telomeric repeat-binding factor 2; Region: TRF2; pfam11611 637381004475 GTPase Era; Reviewed; Region: era; PRK00089 637381004476 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 637381004477 G1 box; other site 637381004478 GTP/Mg2+ binding site [chemical binding]; other site 637381004479 Switch I region; other site 637381004480 G2 box; other site 637381004481 Switch II region; other site 637381004482 G3 box; other site 637381004483 G4 box; other site 637381004484 G5 box; other site 637381004485 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 637381004486 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 637381004487 active site 637381004488 catalytic motif [active] 637381004489 Zn binding site [ion binding]; other site 637381004490 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 637381004491 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 637381004492 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 637381004493 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 637381004494 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637381004495 Zn2+ binding site [ion binding]; other site 637381004496 Mg2+ binding site [ion binding]; other site 637381004497 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 637381004498 PhoH-like protein; Region: PhoH; cl12134 637381004499 GatB domain; Region: GatB_Yqey; cl11497 637381004500 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 637381004501 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 637381004502 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 637381004503 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637381004504 S-adenosylmethionine binding site [chemical binding]; other site 637381004505 chaperone protein DnaJ; Provisional; Region: PRK14280 637381004506 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 637381004507 HSP70 interaction site [polypeptide binding]; other site 637381004508 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 637381004509 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 637381004510 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 637381004511 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 637381004512 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 637381004513 dimer interface [polypeptide binding]; other site 637381004514 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 637381004515 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 637381004516 HrcA protein C terminal domain; Region: HrcA; pfam01628 637381004517 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 637381004518 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 637381004519 FeS/SAM binding site; other site 637381004520 HemN C-terminal region; Region: HemN_C; pfam06969 637381004521 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 637381004522 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 637381004523 NADP binding site [chemical binding]; other site 637381004524 putative substrate binding site [chemical binding]; other site 637381004525 active site 637381004526 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 637381004527 DNA binding residues [nucleotide binding] 637381004528 putative dimer interface [polypeptide binding]; other site 637381004529 GTP-binding protein LepA; Provisional; Region: PRK05433 637381004530 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 637381004531 G1 box; other site 637381004532 putative GEF interaction site [polypeptide binding]; other site 637381004533 GTP/Mg2+ binding site [chemical binding]; other site 637381004534 Switch I region; other site 637381004535 G2 box; other site 637381004536 G3 box; other site 637381004537 Switch II region; other site 637381004538 G4 box; other site 637381004539 G5 box; other site 637381004540 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 637381004541 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 637381004542 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 637381004543 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 637381004544 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 637381004545 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 637381004546 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 637381004547 Competence protein; Region: Competence; cl00471 637381004548 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637381004549 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 637381004550 catalytic motif [active] 637381004551 Zn binding site [ion binding]; other site 637381004552 SLBB domain; Region: SLBB; pfam10531 637381004553 comEA protein; Region: comE; TIGR01259 637381004554 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 637381004555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637381004556 S-adenosylmethionine binding site [chemical binding]; other site 637381004557 Domain of unknown function DUF143; Region: DUF143; cl00519 637381004558 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 637381004559 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 637381004560 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 637381004561 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 637381004562 active site 637381004563 (T/H)XGH motif; other site 637381004564 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 637381004565 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 637381004566 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 637381004567 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 637381004568 shikimate binding site; other site 637381004569 NAD(P) binding site [chemical binding]; other site 637381004570 GTPase YqeH; Provisional; Region: PRK13796 637381004571 YqeH. YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess initiation of DNA replication, suggesting that it negatively controls initiation of chromosome replication. The YqeH subfamily is common in eukaryotes and sporadically...; Region: YqeH; cd01855 637381004572 GTP/Mg2+ binding site [chemical binding]; other site 637381004573 G4 box; other site 637381004574 G5 box; other site 637381004575 G1 box; other site 637381004576 Switch I region; other site 637381004577 G2 box; other site 637381004578 G3 box; other site 637381004579 Switch II region; other site 637381004580 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637381004581 motif II; other site 637381004582 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 637381004583 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 637381004584 active site 637381004585 Zn binding site [ion binding]; other site 637381004586 Integrase core domain; Region: rve; cl01316 637381004587 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 637381004588 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Provisional; Region: PRK07164 637381004589 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 637381004590 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 637381004591 domain; Region: GreA_GreB_N; pfam03449 637381004592 C-term; Region: GreA_GreB; pfam01272 637381004593 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage...; Region: UMPK; cd02023 637381004594 Sugar specificity; other site 637381004595 Pyrimidine base specificity; other site 637381004596 ATP-binding site [chemical binding]; other site 637381004597 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 637381004598 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637381004599 S-adenosylmethionine binding site [chemical binding]; other site 637381004600 YceG-like family; Region: YceG; pfam02618 637381004601 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 637381004602 dimerization interface [polypeptide binding]; other site 637381004603 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 637381004604 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 637381004605 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 637381004606 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 637381004607 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 637381004608 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 637381004609 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 637381004610 active site 637381004611 motif 2; other site 637381004612 motif 3; other site 637381004613 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 637381004614 DHHA1 domain; Region: DHHA1; pfam02272 637381004615 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637381004616 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 637381004617 Walker A/P-loop; other site 637381004618 ATP binding site [chemical binding]; other site 637381004619 Q-loop/lid; other site 637381004620 ABC transporter signature motif; other site 637381004621 Walker B; other site 637381004622 D-loop; other site 637381004623 H-loop/switch region; other site 637381004624 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 637381004625 FtsX-like permease family; Region: FtsX; pfam02687 637381004626 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637381004627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637381004628 active site 637381004629 phosphorylation site [posttranslational modification] 637381004630 intermolecular recognition site; other site 637381004631 dimerization interface [polypeptide binding]; other site 637381004632 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637381004633 DNA binding site [nucleotide binding] 637381004634 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 637381004635 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 637381004636 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637381004637 dimer interface [polypeptide binding]; other site 637381004638 phosphorylation site [posttranslational modification] 637381004639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637381004640 ATP binding site [chemical binding]; other site 637381004641 Mg2+ binding site [ion binding]; other site 637381004642 G-X-G motif; other site 637381004643 RecD/TraA family; Region: recD_rel; TIGR01448 637381004644 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381004645 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 637381004646 binding surface 637381004647 TPR motif; other site 637381004648 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 637381004649 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 637381004650 binding surface 637381004651 TPR motif; other site 637381004652 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 637381004653 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 637381004654 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 637381004655 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 637381004656 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 637381004657 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637381004658 catalytic residue [active] 637381004659 recombination factor protein RarA; Reviewed; Region: PRK13342 637381004660 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637381004661 Walker A motif; other site 637381004662 ATP binding site [chemical binding]; other site 637381004663 Walker B motif; other site 637381004664 arginine finger; other site 637381004665 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 637381004666 Predicted transcriptional regulator [Transcription]; Region: COG1959 637381004667 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381004668 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 637381004669 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 637381004670 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 637381004671 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 637381004672 dimer interface [polypeptide binding]; other site 637381004673 anticodon binding site; other site 637381004674 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 637381004675 homodimer interface [polypeptide binding]; other site 637381004676 motif 1; other site 637381004677 active site 637381004678 motif 2; other site 637381004679 GAD domain; Region: GAD; pfam02938 637381004680 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 637381004681 motif 3; other site 637381004682 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 637381004683 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 637381004684 dimer interface [polypeptide binding]; other site 637381004685 motif 1; other site 637381004686 active site 637381004687 motif 2; other site 637381004688 motif 3; other site 637381004689 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 637381004690 anticodon binding site; other site 637381004691 Bacterial SH3 domain; Region: SH3_3; cl02551 637381004692 Bacterial SH3 domain; Region: SH3_3; cl02551 637381004693 Bacterial SH3 domain; Region: SH3_3; cl02551 637381004694 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 637381004695 active site 637381004696 metal binding site [ion binding]; metal-binding site 637381004697 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563 637381004698 putative active site [active] 637381004699 dimerization interface [polypeptide binding]; other site 637381004700 putative tRNAtyr binding site [nucleotide binding]; other site 637381004701 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 637381004702 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 637381004703 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 637381004704 synthetase active site [active] 637381004705 NTP binding site [chemical binding]; other site 637381004706 metal binding site [ion binding]; metal-binding site 637381004707 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 637381004708 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 637381004709 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 637381004710 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 637381004711 DHH family; Region: DHH; pfam01368 637381004712 DHHA1 domain; Region: DHHA1; pfam02272 637381004713 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 637381004714 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 637381004715 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 637381004716 Protein export membrane protein; Region: SecD_SecF; cl14618 637381004717 Protein export membrane protein; Region: SecD_SecF; cl14618 637381004718 Preprotein translocase subunit; Region: YajC; cl00806 637381004719 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 637381004720 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 637381004721 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 637381004722 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 637381004723 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637381004724 Walker A motif; other site 637381004725 ATP binding site [chemical binding]; other site 637381004726 Walker B motif; other site 637381004727 arginine finger; other site 637381004728 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 637381004729 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 637381004730 RuvA N terminal domain; Region: RuvA_N; pfam01330 637381004731 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 637381004732 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 637381004733 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637381004734 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 637381004735 NAD binding site [chemical binding]; other site 637381004736 dimer interface [polypeptide binding]; other site 637381004737 substrate binding site [chemical binding]; other site 637381004738 Domain of unknown function DUF28; Region: DUF28; cl00361 637381004739 prephenate dehydratase; Provisional; Region: PRK11898 637381004740 Prephenate dehydratase; Region: PDT; pfam00800 637381004741 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 637381004742 putative L-Phe binding site [chemical binding]; other site 637381004743 GTPase CgtA; Reviewed; Region: obgE; PRK12297 637381004744 GTP1/OBG; Region: GTP1_OBG; pfam01018 637381004745 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 637381004746 G1 box; other site 637381004747 GTP/Mg2+ binding site [chemical binding]; other site 637381004748 Switch I region; other site 637381004749 G2 box; other site 637381004750 G3 box; other site 637381004751 Switch II region; other site 637381004752 G4 box; other site 637381004753 G5 box; other site 637381004754 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 637381004755 glycerol kinase; Provisional; Region: glpK; PRK00047 637381004756 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 637381004757 N- and C-terminal domain interface [polypeptide binding]; other site 637381004758 active site 637381004759 MgATP binding site [chemical binding]; other site 637381004760 catalytic site [active] 637381004761 metal binding site [ion binding]; metal-binding site 637381004762 glycerol binding site [chemical binding]; other site 637381004763 homotetramer interface [polypeptide binding]; other site 637381004764 homodimer interface [polypeptide binding]; other site 637381004765 FBP binding site [chemical binding]; other site 637381004766 protein IIAGlc interface [polypeptide binding]; other site 637381004767 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cd00333 637381004768 amphipathic channel; other site 637381004769 Asn-Pro-Ala signature motifs; other site 637381004770 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 637381004771 Protein of unknown function (DUF464); Region: DUF464; cl01080 637381004772 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 637381004773 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 637381004774 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 637381004775 homodimer interface [polypeptide binding]; other site 637381004776 oligonucleotide binding site [chemical binding]; other site 637381004777 septum site-determining protein MinD; Region: minD_bact; TIGR01968 637381004778 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a...; Region: MinD; cd02036 637381004779 Switch I; other site 637381004780 Switch II; other site 637381004781 septum formation inhibitor; Reviewed; Region: minC; PRK00513 637381004782 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 637381004783 rod shape-determining protein MreD; Region: MreD; cl01087 637381004784 rod shape-determining protein MreC; Provisional; Region: PRK13922 637381004785 rod shape-determining protein MreC; Region: MreC; pfam04085 637381004786 rod shape-determining protein MreB; Provisional; Region: PRK13927 637381004787 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 637381004788 ATP binding site [chemical binding]; other site 637381004789 profilin binding site; other site 637381004790 hypothetical protein; Reviewed; Region: PRK00024 637381004791 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 637381004792 MPN+ (JAMM) motif; other site 637381004793 Zinc-binding site [ion binding]; other site 637381004794 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 637381004795 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 637381004796 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 637381004797 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637381004798 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637381004799 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 637381004800 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 637381004801 active site 637381004802 HIGH motif; other site 637381004803 nucleotide binding site [chemical binding]; other site 637381004804 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 637381004805 active site 637381004806 KMSKS motif; other site 637381004807 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 637381004808 tRNA binding surface [nucleotide binding]; other site 637381004809 anticodon binding site; other site 637381004810 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 637381004811 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 637381004812 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 637381004813 inhibitor-cofactor binding pocket; inhibition site 637381004814 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637381004815 catalytic residue [active] 637381004816 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 637381004817 dimer interface [polypeptide binding]; other site 637381004818 active site 637381004819 Schiff base residues; other site 637381004820 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 637381004821 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 637381004822 active site 637381004823 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 637381004824 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 637381004825 domain interfaces; other site 637381004826 active site 637381004827 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 637381004828 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 637381004829 tRNA; other site 637381004830 putative tRNA binding site [nucleotide binding]; other site 637381004831 putative NADP binding site [chemical binding]; other site 637381004832 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 637381004833 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 637381004834 G1 box; other site 637381004835 GTP/Mg2+ binding site [chemical binding]; other site 637381004836 Switch I region; other site 637381004837 G2 box; other site 637381004838 G3 box; other site 637381004839 Switch II region; other site 637381004840 G4 box; other site 637381004841 G5 box; other site 637381004842 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 637381004843 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase...; Region: TGS_ThrRS_N; cd01667 637381004844 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 637381004845 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 637381004846 active site 637381004847 dimer interface [polypeptide binding]; other site 637381004848 motif 1; other site 637381004849 motif 2; other site 637381004850 motif 3; other site 637381004851 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 637381004852 anticodon binding site; other site 637381004853 primosomal protein DnaI; Reviewed; Region: PRK08939 637381004854 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 637381004855 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 637381004856 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 637381004857 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 637381004858 ATP cone domain; Region: ATP-cone; pfam03477 637381004859 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 637381004860 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 637381004861 CoA-binding site [chemical binding]; other site 637381004862 ATP-binding [chemical binding]; other site 637381004863 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 637381004864 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 637381004865 DNA binding site [nucleotide binding] 637381004866 catalytic residue [active] 637381004867 H2TH interface [polypeptide binding]; other site 637381004868 putative catalytic residues [active] 637381004869 turnover-facilitating residue; other site 637381004870 intercalation triad [nucleotide binding]; other site 637381004871 8OG recognition residue [nucleotide binding]; other site 637381004872 putative reading head residues; other site 637381004873 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 637381004874 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 637381004875 DNA polymerase I; Provisional; Region: PRK05755 637381004876 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 637381004877 active site 637381004878 metal binding site 1 [ion binding]; metal-binding site 637381004879 putative 5' ssDNA interaction site; other site 637381004880 metal binding site 3; metal-binding site 637381004881 metal binding site 2 [ion binding]; metal-binding site 637381004882 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 637381004883 putative DNA binding site [nucleotide binding]; other site 637381004884 putative metal binding site [ion binding]; other site 637381004885 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 637381004886 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 637381004887 active site 637381004888 DNA binding site [nucleotide binding] 637381004889 catalytic site [active] 637381004890 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 637381004891 isocitrate dehydrogenase; Validated; Region: PRK07362 637381004892 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes...; Region: BSuCS-II_like; cd06110 637381004893 dimer interface [polypeptide binding]; other site 637381004894 Citrate synthase; Region: Citrate_synt; pfam00285 637381004895 active site 637381004896 citrylCoA binding site [chemical binding]; other site 637381004897 oxalacetate/citrate binding site [chemical binding]; other site 637381004898 coenzyme A binding site [chemical binding]; other site 637381004899 catalytic triad [active] 637381004900 Protein of unknown function (DUF441); Region: DUF441; cl01041 637381004901 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 637381004902 pyruvate kinase; Provisional; Region: PRK06354 637381004903 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 637381004904 domain interfaces; other site 637381004905 active site 637381004906 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 637381004907 6-phosphofructokinase; Provisional; Region: PRK03202 637381004908 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 637381004909 active site 637381004910 ADP/pyrophosphate binding site [chemical binding]; other site 637381004911 dimerization interface [polypeptide binding]; other site 637381004912 allosteric effector site; other site 637381004913 fructose-1,6-bisphosphate binding site; other site 637381004914 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 637381004915 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 637381004916 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 637381004917 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 637381004918 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 637381004919 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 637381004920 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 637381004921 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 637381004922 generic binding surface I; other site 637381004923 generic binding surface II; other site 637381004924 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 637381004925 DHH family; Region: DHH; pfam01368 637381004926 DHHA1 domain; Region: DHHA1; pfam02272 637381004927 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 637381004928 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381004929 DNA-binding site [nucleotide binding]; DNA binding site 637381004930 DRTGG domain; Region: DRTGG; cl12147 637381004931 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 637381004932 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637381004933 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 637381004934 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 637381004935 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 637381004936 active site 637381004937 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 637381004938 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 637381004939 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381004940 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 637381004941 Ligand Binding Site [chemical binding]; other site 637381004942 Acetokinase family; Region: Acetate_kinase; cl01029 637381004943 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 637381004944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637381004945 S-adenosylmethionine binding site [chemical binding]; other site 637381004946 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 637381004947 dimer interface [polypeptide binding]; other site 637381004948 catalytic triad [active] 637381004949 peroxidatic and resolving cysteines [active] 637381004950 RDD family; Region: RDD; cl00746 637381004951 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 637381004952 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 637381004953 tandem repeat interface [polypeptide binding]; other site 637381004954 oligomer interface [polypeptide binding]; other site 637381004955 active site residues [active] 637381004956 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 637381004957 ornithine carbamoyltransferase; Provisional; Region: PRK00779 637381004958 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 637381004959 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381004960 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 637381004961 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 637381004962 inhibitor-cofactor binding pocket; inhibition site 637381004963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637381004964 catalytic residue [active] 637381004965 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 637381004966 nucleotide binding site [chemical binding]; other site 637381004967 N-acetyl-L-glutamate binding site [chemical binding]; other site 637381004968 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152 637381004969 heterotetramer interface [polypeptide binding]; other site 637381004970 active site pocket [active] 637381004971 cleavage site 637381004972 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 637381004973 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381004974 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 637381004975 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 637381004976 THUMP domain; Region: THUMP; cl12076 637381004977 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 637381004978 Ligand Binding Site [chemical binding]; other site 637381004979 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 637381004980 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 637381004981 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637381004982 catalytic residue [active] 637381004983 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 637381004984 GAF domain; Region: GAF; cl00853 637381004985 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 637381004986 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 637381004987 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637381004988 RNA binding surface [nucleotide binding]; other site 637381004989 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 637381004990 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 637381004991 active site 637381004992 HIGH motif; other site 637381004993 dimer interface [polypeptide binding]; other site 637381004994 KMSKS motif; other site 637381004995 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 637381004996 catabolite control protein A; Region: ccpA; TIGR01481 637381004997 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637381004998 DNA binding site [nucleotide binding] 637381004999 domain linker motif; other site 637381005000 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 637381005001 dimerization interface [polypeptide binding]; other site 637381005002 effector binding site; other site 637381005003 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 637381005004 Chorismate mutase type II; Region: CM_2; cl00693 637381005005 NeuB family; Region: NeuB; cl00496 637381005006 YtxH-like protein; Region: YtxH; cl02079 637381005007 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 637381005008 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 637381005009 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 637381005010 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015 637381005011 dimer interface [polypeptide binding]; other site 637381005012 decamer (pentamer of dimers) interface [polypeptide binding]; other site 637381005013 catalytic triad [active] 637381005014 peroxidatic and resolving cysteines [active] 637381005015 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 637381005016 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 637381005017 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637381005018 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637381005019 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 637381005020 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381005021 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 637381005022 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 637381005023 putative tRNA-binding site [nucleotide binding]; other site 637381005024 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 637381005025 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 637381005026 catalytic residues [active] 637381005027 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 637381005028 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 637381005029 oligomer interface [polypeptide binding]; other site 637381005030 active site 637381005031 metal binding site [ion binding]; metal-binding site 637381005032 Predicted small secreted protein [Function unknown]; Region: COG5584 637381005033 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 637381005034 putative homotetramer interface [polypeptide binding]; other site 637381005035 putative homodimer interface [polypeptide binding]; other site 637381005036 putative allosteric switch controlling residues; other site 637381005037 putative metal binding site [ion binding]; other site 637381005038 putative homodimer-homodimer interface [polypeptide binding]; other site 637381005039 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637381005040 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637381005041 Phosphotransferase enzyme family; Region: APH; pfam01636 637381005042 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 637381005043 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 637381005044 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637381005045 putative substrate translocation pore; other site 637381005046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637381005047 Transcriptional regulators [Transcription]; Region: MarR; COG1846 637381005048 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381005049 branched-chain amino acid aminotransferase; Provisional; Region: PRK12479 637381005050 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-...; Region: D-AAT_like; cd01558 637381005051 homodimer interface [polypeptide binding]; other site 637381005052 substrate-cofactor binding pocket; other site 637381005053 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637381005054 catalytic residue [active] 637381005055 dipeptidase PepV; Reviewed; Region: PRK07318 637381005056 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 637381005057 active site 637381005058 metal binding site [ion binding]; metal-binding site 637381005059 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699 637381005060 nudix motif; other site 637381005061 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 637381005062 putative substrate binding site [chemical binding]; other site 637381005063 putative ATP binding site [chemical binding]; other site 637381005064 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 637381005065 active site 637381005066 stage V sporulation protein B; Region: spore_V_B; TIGR02900 637381005067 MatE; Region: MatE; cl10513 637381005068 MatE; Region: MatE; cl10513 637381005069 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 637381005070 tryptophan synthase; Region: PLN02591 637381005071 substrate binding site [chemical binding]; other site 637381005072 active site 637381005073 catalytic residues [active] 637381005074 heterodimer interface [polypeptide binding]; other site 637381005075 tryptophan synthase, beta chain; Region: PLN02618 637381005076 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 637381005077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637381005078 catalytic residue [active] 637381005079 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405 637381005080 active site 637381005081 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 637381005082 active site 637381005083 ribulose/triose binding site [chemical binding]; other site 637381005084 phosphate binding site [ion binding]; other site 637381005085 substrate (anthranilate) binding pocket [chemical binding]; other site 637381005086 product (indole) binding pocket [chemical binding]; other site 637381005087 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 637381005088 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 637381005089 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 637381005090 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 637381005091 Glutamine amidotransferase class-I; Region: GATase; pfam00117 637381005092 glutamine binding [chemical binding]; other site 637381005093 catalytic triad [active] 637381005094 anthranilate synthase component I; Provisional; Region: PRK13570 637381005095 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 637381005096 chorismate binding enzyme; Region: Chorismate_bind; cl10555 637381005097 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 637381005098 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 637381005099 putative catalytic cysteine [active] 637381005100 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 637381005101 putative active site [active] 637381005102 metal binding site [ion binding]; metal-binding site 637381005103 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 637381005104 dimer interface [polypeptide binding]; other site 637381005105 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 637381005106 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 637381005107 Walker A/P-loop; other site 637381005108 ATP binding site [chemical binding]; other site 637381005109 Q-loop/lid; other site 637381005110 ABC transporter signature motif; other site 637381005111 Walker B; other site 637381005112 D-loop; other site 637381005113 H-loop/switch region; other site 637381005114 ABC-2 type transporter; Region: ABC2_membrane; cl11417 637381005115 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 637381005116 putative dimer interface [polypeptide binding]; other site 637381005117 catalytic triad [active] 637381005118 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 637381005119 aconitate hydratase; Validated; Region: PRK09277 637381005120 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 637381005121 substrate binding site [chemical binding]; other site 637381005122 ligand binding site [chemical binding]; other site 637381005123 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 637381005124 substrate binding site [chemical binding]; other site 637381005125 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 637381005126 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 637381005127 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 637381005128 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637381005129 ATP binding site [chemical binding]; other site 637381005130 putative Mg++ binding site [ion binding]; other site 637381005131 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637381005132 nucleotide binding region [chemical binding]; other site 637381005133 ATP-binding site [chemical binding]; other site 637381005134 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 637381005135 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 637381005136 Walker A/P-loop; other site 637381005137 ATP binding site [chemical binding]; other site 637381005138 Q-loop/lid; other site 637381005139 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 637381005140 ABC transporter signature motif; other site 637381005141 Walker B; other site 637381005142 D-loop; other site 637381005143 H-loop/switch region; other site 637381005144 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 637381005145 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 637381005146 active site 637381005147 metal binding site [ion binding]; metal-binding site 637381005148 DNA binding site [nucleotide binding] 637381005149 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 637381005150 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 637381005151 putative acyl-acceptor binding pocket; other site 637381005152 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 637381005153 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637381005154 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 637381005155 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 637381005156 Walker A/P-loop; other site 637381005157 ATP binding site [chemical binding]; other site 637381005158 Q-loop/lid; other site 637381005159 ABC transporter signature motif; other site 637381005160 Walker B; other site 637381005161 D-loop; other site 637381005162 H-loop/switch region; other site 637381005163 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 637381005164 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 637381005165 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381005166 Walker A/P-loop; other site 637381005167 ATP binding site [chemical binding]; other site 637381005168 Q-loop/lid; other site 637381005169 ABC transporter signature motif; other site 637381005170 Walker B; other site 637381005171 D-loop; other site 637381005172 H-loop/switch region; other site 637381005173 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...; Region: ZnMc; cl00064 637381005174 active site 637381005175 VanZ like family; Region: VanZ; cl01971 637381005176 elongation factor Ts; Provisional; Region: tsf; PRK09377 637381005177 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 637381005178 Elongation factor TS; Region: EF_TS; pfam00889 637381005179 Elongation factor TS; Region: EF_TS; pfam00889 637381005180 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 637381005181 rRNA interaction site [nucleotide binding]; other site 637381005182 S8 interaction site; other site 637381005183 putative laminin-1 binding site; other site 637381005184 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 637381005185 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 637381005186 HIGH motif; other site 637381005187 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 637381005188 active site 637381005189 KMSKS motif; other site 637381005190 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 637381005191 tRNA binding surface [nucleotide binding]; other site 637381005192 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 637381005193 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 637381005194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637381005195 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637381005196 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 637381005197 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 637381005198 active site 637381005199 dimer interface [polypeptide binding]; other site 637381005200 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 637381005201 Ligand Binding Site [chemical binding]; other site 637381005202 Molecular Tunnel; other site 637381005203 S-adenosylmethionine synthetase; Validated; Region: PRK05250 637381005204 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 637381005205 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 637381005206 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 637381005207 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 637381005208 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637381005209 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 637381005210 NAD binding site [chemical binding]; other site 637381005211 dimer interface [polypeptide binding]; other site 637381005212 substrate binding site [chemical binding]; other site 637381005213 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 637381005214 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 637381005215 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 637381005216 nudix motif; other site 637381005217 Domain of unknown function DUF37; Region: DUF37; cl00506 637381005218 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 637381005219 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 637381005220 metal binding site [ion binding]; metal-binding site 637381005221 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 637381005222 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 637381005223 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 637381005224 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 637381005225 substrate binding site [chemical binding]; other site 637381005226 oxyanion hole (OAH) forming residues; other site 637381005227 trimer interface [polypeptide binding]; other site 637381005228 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 637381005229 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637381005230 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 637381005231 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 637381005232 dimer interface [polypeptide binding]; other site 637381005233 tetramer interface [polypeptide binding]; other site 637381005234 PYR/PP interface [polypeptide binding]; other site 637381005235 TPP binding site [chemical binding]; other site 637381005236 TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key role in the menaquinone biosynthetic pathway, converting...; Region: TPP_SHCHC_synthase; cd02009 637381005237 TPP-binding site; other site 637381005238 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 637381005239 chorismate binding enzyme; Region: Chorismate_bind; cl10555 637381005240 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; COG1575 637381005241 UbiA prenyltransferase family; Region: UbiA; cl00337 637381005242 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 637381005243 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 637381005244 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 637381005245 FAD binding site [chemical binding]; other site 637381005246 cystathionine beta-lyase; Provisional; Region: PRK08064 637381005247 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 637381005248 homodimer interface [polypeptide binding]; other site 637381005249 substrate-cofactor binding pocket; other site 637381005250 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637381005251 catalytic residue [active] 637381005252 cystathionine gamma-synthase; Reviewed; Region: PRK08247 637381005253 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 637381005254 homodimer interface [polypeptide binding]; other site 637381005255 substrate-cofactor binding pocket; other site 637381005256 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637381005257 catalytic residue [active] 637381005258 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 637381005259 N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_N_terminal_like; cd03312 637381005260 THF binding site; other site 637381005261 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311 637381005262 substrate binding site [chemical binding]; other site 637381005263 THF binding site; other site 637381005264 zinc-binding site [ion binding]; other site 637381005265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637381005266 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637381005267 putative substrate translocation pore; other site 637381005268 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 637381005269 metal binding site 2 [ion binding]; metal-binding site 637381005270 putative DNA binding helix; other site 637381005271 metal binding site 1 [ion binding]; metal-binding site 637381005272 dimer interface [polypeptide binding]; other site 637381005273 structural Zn2+ binding site [ion binding]; other site 637381005274 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 637381005275 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381005276 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 637381005277 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 637381005278 inhibitor-cofactor binding pocket; inhibition site 637381005279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637381005280 catalytic residue [active] 637381005281 Predicted membrane protein [Function unknown]; Region: COG4129 637381005282 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 637381005283 Protein of unknown function (DUF402); Region: DUF402; cl00979 637381005284 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 637381005285 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 637381005286 putative NAD(P) binding site [chemical binding]; other site 637381005287 active site 637381005288 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 637381005289 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 637381005290 minor groove reading motif; other site 637381005291 helix-hairpin-helix signature motif; other site 637381005292 substrate binding pocket [chemical binding]; other site 637381005293 active site 637381005294 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 637381005295 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 637381005296 DNA binding and oxoG recognition site [nucleotide binding] 637381005297 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 637381005298 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 637381005299 trimer interface [polypeptide binding]; other site 637381005300 active site 637381005301 RecX family; Region: RecX; cl00936 637381005302 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381005303 TIGR01777 family protein; Region: yfcH 637381005304 NAD(P) binding site [chemical binding]; other site 637381005305 active site 637381005306 Predicted integral membrane protein [Function unknown]; Region: COG0392 637381005307 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 637381005308 Uncharacterized conserved protein [Function unknown]; Region: COG2898 637381005309 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 637381005310 VanZ like family; Region: VanZ; cl01971 637381005311 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 637381005312 Cation efflux family; Region: Cation_efflux; cl00316 637381005313 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637381005314 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637381005315 PAS fold; Region: PAS_4; pfam08448 637381005316 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637381005317 putative active site [active] 637381005318 heme pocket [chemical binding]; other site 637381005319 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 637381005320 FosX, a fosfomycin resistance protein, catalyzes the addition of a water molecule to the C1 position of the antibiotic with inversion of configuration at C1; Region: FosX; cd08364 637381005321 dimer interface [polypeptide binding]; other site 637381005322 active site 637381005323 Mn binding site [ion binding]; other site 637381005324 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 637381005325 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 637381005326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 637381005327 active site 637381005328 phosphorylation site [posttranslational modification] 637381005329 intermolecular recognition site; other site 637381005330 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 637381005331 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 637381005332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637381005333 ATP binding site [chemical binding]; other site 637381005334 Mg2+ binding site [ion binding]; other site 637381005335 G-X-G motif; other site 637381005336 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 637381005337 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637381005338 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 637381005339 catalytic residues [active] 637381005340 catalytic nucleophile [active] 637381005341 Recombinase; Region: Recombinase; pfam07508 637381005342 Recombinase; Region: Recombinase; pfam07508 637381005343 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 637381005344 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 637381005345 catalytic residues [active] 637381005346 catalytic nucleophile [active] 637381005347 Recombinase; Region: Recombinase; pfam07508 637381005348 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 637381005349 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 637381005350 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381005351 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 637381005352 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381005353 DNA-binding site [nucleotide binding]; DNA binding site 637381005354 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 637381005355 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381005356 Walker A motif; other site 637381005357 ATP binding site [chemical binding]; other site 637381005358 Walker B motif; other site 637381005359 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication...; Region: TOPRIM_primases; cd01029 637381005360 active site 637381005361 metal binding site [ion binding]; metal-binding site 637381005362 interdomain interaction site; other site 637381005363 Sel1 repeat; Region: Sel1; cl02723 637381005364 Sel1 repeat; Region: Sel1; cl02723 637381005365 Sel1 repeat; Region: Sel1; cl02723 637381005366 Sel1 repeat; Region: Sel1; cl02723 637381005367 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 637381005368 Sel1 repeat; Region: Sel1; cl02723 637381005369 Sel1 repeat; Region: Sel1; cl02723 637381005370 Sel1 repeat; Region: Sel1; cl02723 637381005371 Sel1 repeat; Region: Sel1; cl02723 637381005372 Sel1 repeat; Region: Sel1; cl02723 637381005373 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 637381005374 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 637381005375 NlpC/P60 family; Region: NLPC_P60; cl11438 637381005376 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 637381005377 putative active site pocket [active] 637381005378 dimerization interface [polypeptide binding]; other site 637381005379 putative catalytic residue [active] 637381005380 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 637381005381 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 637381005382 AAA-like domain; Region: AAA_10; pfam12846 637381005383 Protein of unknown function (DUF3852); Region: DUF3852; pfam12963 637381005384 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 637381005385 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 637381005386 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381005387 Walker A motif; other site 637381005388 ATP binding site [chemical binding]; other site 637381005389 Walker B motif; other site 637381005390 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 637381005391 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 637381005392 SAF domain; Region: SAF; cl00555 637381005393 SpoVG; Region: SpoVG; cl00915 637381005394 cell division protein MraZ; Reviewed; Region: PRK00326 637381005395 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408 637381005396 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138 637381005397 putative active site [active] 637381005398 catalytic site [active] 637381005399 nuclease NucT; Provisional; Region: PRK13912 637381005400 TRAM domain; Region: TRAM; cl01282 637381005401 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 637381005402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637381005403 S-adenosylmethionine binding site [chemical binding]; other site 637381005404 OsmC-like protein; Region: OsmC; cl00767 637381005405 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 637381005406 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7...; Region: dNK; cd01673 637381005407 Substrate-binding site [chemical binding]; other site 637381005408 Substrate specificity [chemical binding]; other site 637381005409 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 637381005410 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 637381005411 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 637381005412 methionine aminopeptidase; Reviewed; Region: PRK07281 637381005413 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 637381005414 active site 637381005415 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 637381005416 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 637381005417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637381005418 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637381005419 putative substrate translocation pore; other site 637381005420 rod-share determining protein MreBH; Provisional; Region: PRK13929 637381005421 Cell division protein FtsA; Region: FtsA; cl11496 637381005422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637381005423 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637381005424 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637381005425 Uncharacterized conserved protein [Function unknown]; Region: COG3589 637381005426 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 637381005427 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 637381005428 methionine cluster; other site 637381005429 active site 637381005430 phosphorylation site [posttranslational modification] 637381005431 metal binding site [ion binding]; metal-binding site 637381005432 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564 637381005433 active site 637381005434 P-loop; other site 637381005435 phosphorylation site [posttranslational modification] 637381005436 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381005437 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 637381005438 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637381005439 Walker A motif; other site 637381005440 ATP binding site [chemical binding]; other site 637381005441 Walker B motif; other site 637381005442 arginine finger; other site 637381005443 Transcriptional antiterminator [Transcription]; Region: COG3933 637381005444 PRD domain; Region: PRD; pfam00874 637381005445 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006 637381005446 active pocket/dimerization site; other site 637381005447 active site 637381005448 phosphorylation site [posttranslational modification] 637381005449 PRD domain; Region: PRD; pfam00874 637381005450 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381005451 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 637381005452 ATP binding site [chemical binding]; other site 637381005453 putative Mg++ binding site [ion binding]; other site 637381005454 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637381005455 nucleotide binding region [chemical binding]; other site 637381005456 ATP-binding site [chemical binding]; other site 637381005457 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 637381005458 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 637381005459 Walker A/P-loop; other site 637381005460 ATP binding site [chemical binding]; other site 637381005461 Q-loop/lid; other site 637381005462 ABC transporter signature motif; other site 637381005463 Walker B; other site 637381005464 D-loop; other site 637381005465 H-loop/switch region; other site 637381005466 Predicted transcriptional regulators [Transcription]; Region: COG1725 637381005467 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637381005468 DNA-binding site [nucleotide binding]; DNA binding site 637381005469 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 637381005470 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381005471 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637381005472 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637381005473 DNA binding site [nucleotide binding] 637381005474 domain linker motif; other site 637381005475 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 637381005476 dimerization interface [polypeptide binding]; other site 637381005477 ligand binding site [chemical binding]; other site 637381005478 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 637381005479 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 637381005480 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 637381005481 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 637381005482 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 637381005483 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637381005484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381005485 dimer interface [polypeptide binding]; other site 637381005486 conserved gate region; other site 637381005487 putative PBP binding loops; other site 637381005488 ABC-ATPase subunit interface; other site 637381005489 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 637381005490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381005491 dimer interface [polypeptide binding]; other site 637381005492 conserved gate region; other site 637381005493 putative PBP binding loops; other site 637381005494 ABC-ATPase subunit interface; other site 637381005495 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 637381005496 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381005497 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 637381005498 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713 637381005499 active site 637381005500 dimer interface [polypeptide binding]; other site 637381005501 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 637381005502 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 637381005503 active site 637381005504 FMN binding site [chemical binding]; other site 637381005505 substrate binding site [chemical binding]; other site 637381005506 3Fe-4S cluster binding site [ion binding]; other site 637381005507 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 637381005508 domain interface; other site 637381005509 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637381005510 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381005511 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 637381005512 putative dimerization interface [polypeptide binding]; other site 637381005513 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637381005514 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 637381005515 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 637381005516 putative active site [active] 637381005517 metal binding site [ion binding]; metal-binding site 637381005518 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 637381005519 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 637381005520 substrate binding pocket [chemical binding]; other site 637381005521 membrane-bound complex binding site; other site 637381005522 hinge residues; other site 637381005523 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637381005524 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381005525 Walker A/P-loop; other site 637381005526 ATP binding site [chemical binding]; other site 637381005527 Q-loop/lid; other site 637381005528 ABC transporter signature motif; other site 637381005529 Walker B; other site 637381005530 D-loop; other site 637381005531 H-loop/switch region; other site 637381005532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381005533 dimer interface [polypeptide binding]; other site 637381005534 conserved gate region; other site 637381005535 putative PBP binding loops; other site 637381005536 ABC-ATPase subunit interface; other site 637381005537 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 637381005538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637381005539 ATP binding site [chemical binding]; other site 637381005540 Mg2+ binding site [ion binding]; other site 637381005541 G-X-G motif; other site 637381005542 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 637381005543 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 637381005544 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen...; Region: AdeC; cd01295 637381005545 active site 637381005546 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 637381005547 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 637381005548 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 637381005549 putative NAD(P) binding site [chemical binding]; other site 637381005550 active site 637381005551 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637381005552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637381005553 active site 637381005554 phosphorylation site [posttranslational modification] 637381005555 intermolecular recognition site; other site 637381005556 dimerization interface [polypeptide binding]; other site 637381005557 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637381005558 DNA binding site [nucleotide binding] 637381005559 FtsX-like permease family; Region: FtsX; pfam02687 637381005560 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637381005561 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 637381005562 Walker A/P-loop; other site 637381005563 ATP binding site [chemical binding]; other site 637381005564 Q-loop/lid; other site 637381005565 ABC transporter signature motif; other site 637381005566 Walker B; other site 637381005567 D-loop; other site 637381005568 H-loop/switch region; other site 637381005569 shikimate kinase; Reviewed; Region: aroK; PRK00131 637381005570 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 637381005571 ADP binding site [chemical binding]; other site 637381005572 magnesium binding site [ion binding]; other site 637381005573 putative shikimate binding site; other site 637381005574 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 637381005575 TRAM domain; Region: TRAM; cl01282 637381005576 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 637381005577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637381005578 putative lipid kinase; Reviewed; Region: PRK13337 637381005579 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 637381005580 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 637381005581 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 637381005582 GatB domain; Region: GatB_Yqey; cl11497 637381005583 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 637381005584 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 637381005585 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 637381005586 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 637381005587 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 637381005588 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 637381005589 nucleotide binding pocket [chemical binding]; other site 637381005590 K-X-D-G motif; other site 637381005591 catalytic site [active] 637381005592 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 637381005593 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 637381005594 Dimer interface [polypeptide binding]; other site 637381005595 BRCT sequence motif; other site 637381005596 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 637381005597 UvrD/REP helicase; Region: UvrD-helicase; cl14126 637381005598 Predicted phosphate-binding enzymes, TIM-barrel fold [General function prediction only]; Region: COG1646 637381005599 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between sn-glycerol-1-...; Region: PcrB_like; cd02812 637381005600 substrate binding site [chemical binding]; other site 637381005601 putative active site [active] 637381005602 dimer interface [polypeptide binding]; other site 637381005603 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 637381005604 Trp repressor protein; Region: Trp_repressor; cl01121 637381005605 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 637381005606 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 637381005607 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 637381005608 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 637381005609 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 637381005610 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 637381005611 purine monophosphate binding site [chemical binding]; other site 637381005612 dimer interface [polypeptide binding]; other site 637381005613 putative catalytic residues [active] 637381005614 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 637381005615 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 637381005616 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 637381005617 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 637381005618 active site 637381005619 substrate binding site [chemical binding]; other site 637381005620 cosubstrate binding site; other site 637381005621 catalytic site [active] 637381005622 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 637381005623 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 637381005624 dimerization interface [polypeptide binding]; other site 637381005625 putative ATP binding site [chemical binding]; other site 637381005626 amidophosphoribosyltransferase; Provisional; Region: PRK06781 637381005627 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 637381005628 active site 637381005629 tetramer interface [polypeptide binding]; other site 637381005630 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 637381005631 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 637381005632 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 637381005633 dimerization interface [polypeptide binding]; other site 637381005634 ATP binding site [chemical binding]; other site 637381005635 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 637381005636 dimerization interface [polypeptide binding]; other site 637381005637 ATP binding site [chemical binding]; other site 637381005638 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 637381005639 putative active site [active] 637381005640 catalytic triad [active] 637381005641 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 637381005642 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 637381005643 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 637381005644 ATP binding site [chemical binding]; other site 637381005645 active site 637381005646 substrate binding site [chemical binding]; other site 637381005647 adenylosuccinate lyase; Provisional; Region: PRK07492 637381005648 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 637381005649 tetramer interface [polypeptide binding]; other site 637381005650 active site 637381005651 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381005652 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 637381005653 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 637381005654 AIR carboxylase; Region: AIRC; cl00310 637381005655 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 637381005656 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 637381005657 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 637381005658 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 637381005659 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 637381005660 Walker A/P-loop; other site 637381005661 ATP binding site [chemical binding]; other site 637381005662 Q-loop/lid; other site 637381005663 ABC transporter signature motif; other site 637381005664 Walker B; other site 637381005665 D-loop; other site 637381005666 H-loop/switch region; other site 637381005667 peptidase T; Region: peptidase-T; TIGR01882 637381005668 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 637381005669 metal binding site [ion binding]; metal-binding site 637381005670 dimer interface [polypeptide binding]; other site 637381005671 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 637381005672 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 637381005673 active site 637381005674 DNA binding site [nucleotide binding] 637381005675 putative phosphate binding site [ion binding]; other site 637381005676 putative catalytic site [active] 637381005677 metal binding site A [ion binding]; metal-binding site 637381005678 AP binding site [nucleotide binding]; other site 637381005679 metal binding site B [ion binding]; metal-binding site 637381005680 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 637381005681 23S rRNA binding site [nucleotide binding]; other site 637381005682 L21 binding site [polypeptide binding]; other site 637381005683 L13 binding site [polypeptide binding]; other site 637381005684 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 637381005685 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 637381005686 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 637381005687 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 637381005688 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 637381005689 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637381005690 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309 637381005691 Substrate binding site [chemical binding]; other site 637381005692 LRR adjacent; Region: LRR_adjacent; pfam08191 637381005693 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 637381005694 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 637381005695 DNA binding residues [nucleotide binding] 637381005696 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 637381005697 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637381005698 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 637381005699 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 637381005700 RimM N-terminal domain; Region: RimM; pfam01782 637381005701 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 637381005702 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 637381005703 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 637381005704 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 637381005705 catalytic triad [active] 637381005706 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794 637381005707 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 637381005708 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 637381005709 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 637381005710 signal recognition particle protein; Provisional; Region: PRK10867 637381005711 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 637381005712 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 637381005713 P loop; other site 637381005714 GTP binding site [chemical binding]; other site 637381005715 Signal peptide binding domain; Region: SRP_SPB; pfam02978 637381005716 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 637381005717 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 637381005718 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 637381005719 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 637381005720 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 637381005721 P loop; other site 637381005722 GTP binding site [chemical binding]; other site 637381005723 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 637381005724 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 637381005725 Walker A/P-loop; other site 637381005726 ATP binding site [chemical binding]; other site 637381005727 Q-loop/lid; other site 637381005728 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 637381005729 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 637381005730 ABC transporter signature motif; other site 637381005731 Walker B; other site 637381005732 D-loop; other site 637381005733 H-loop/switch region; other site 637381005734 ribonuclease III; Reviewed; Region: rnc; PRK00102 637381005735 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 637381005736 dimerization interface [polypeptide binding]; other site 637381005737 active site 637381005738 metal binding site [ion binding]; metal-binding site 637381005739 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 637381005740 dsRNA binding site [nucleotide binding]; other site 637381005741 Phosphopantetheine attachment site; Region: PP-binding; cl09936 637381005742 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 637381005743 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 637381005744 NAD(P) binding site [chemical binding]; other site 637381005745 homotetramer interface [polypeptide binding]; other site 637381005746 homodimer interface [polypeptide binding]; other site 637381005747 active site 637381005748 Acyl transferase domain; Region: Acyl_transf_1; cl08282 637381005749 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 637381005750 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 637381005751 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 637381005752 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 637381005753 Y-family of DNA polymerases; Region: PolY; cl12025 637381005754 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 637381005755 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 637381005756 generic binding surface II; other site 637381005757 ssDNA binding site; other site 637381005758 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637381005759 ATP binding site [chemical binding]; other site 637381005760 putative Mg++ binding site [ion binding]; other site 637381005761 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637381005762 nucleotide binding region [chemical binding]; other site 637381005763 ATP-binding site [chemical binding]; other site 637381005764 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 637381005765 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 637381005766 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 637381005767 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 637381005768 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 637381005769 putative L-serine binding site [chemical binding]; other site 637381005770 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 637381005771 DAK2 domain; Region: Dak2; cl03685 637381005772 Protein of unknown function (DUF322); Region: DUF322; cl00574 637381005773 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 637381005774 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 637381005775 Thiamine pyrophosphokinase; Region: TPK; cd07995 637381005776 active site 637381005777 dimerization interface [polypeptide binding]; other site 637381005778 thiamine binding site [chemical binding]; other site 637381005779 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 637381005780 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 637381005781 substrate binding site [chemical binding]; other site 637381005782 hexamer interface [polypeptide binding]; other site 637381005783 metal binding site [ion binding]; metal-binding site 637381005784 GTPase RsgA; Reviewed; Region: PRK00098 637381005785 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 637381005786 GTPase/OB domain interface [polypeptide binding]; other site 637381005787 GTPase/Zn-binding domain interface [polypeptide binding]; other site 637381005788 GTP/Mg2+ binding site [chemical binding]; other site 637381005789 G4 box; other site 637381005790 G1 box; other site 637381005791 Switch I region; other site 637381005792 G2 box; other site 637381005793 G3 box; other site 637381005794 Switch II region; other site 637381005795 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 637381005796 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 637381005797 active site 637381005798 ATP binding site [chemical binding]; other site 637381005799 substrate binding site [chemical binding]; other site 637381005800 activation loop (A-loop); other site 637381005801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 637381005802 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 637381005803 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 637381005804 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 637381005805 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 637381005806 Protein phosphatase 2C; Region: PP2C; pfam00481 637381005807 Active site [active] 637381005808 16S rRNA methyltransferase B; Provisional; Region: PRK14902 637381005809 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 637381005810 putative RNA binding site [nucleotide binding]; other site 637381005811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637381005812 S-adenosylmethionine binding site [chemical binding]; other site 637381005813 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 637381005814 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 637381005815 putative active site [active] 637381005816 substrate binding site [chemical binding]; other site 637381005817 putative cosubstrate binding site; other site 637381005818 catalytic site [active] 637381005819 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 637381005820 substrate binding site [chemical binding]; other site 637381005821 primosome assembly protein PriA; Validated; Region: PRK05580 637381005822 primosome assembly protein PriA; Validated; Region: PRK05580 637381005823 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637381005824 ATP binding site [chemical binding]; other site 637381005825 putative Mg++ binding site [ion binding]; other site 637381005826 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381005827 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 637381005828 Flavoprotein; Region: Flavoprotein; cl08021 637381005829 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 637381005830 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 637381005831 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 637381005832 catalytic site [active] 637381005833 G-X2-G-X-G-K; other site 637381005834 hypothetical protein; Provisional; Region: PRK11820 637381005835 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 637381005836 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 637381005837 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 637381005838 Domain of unknown function (DUF814); Region: DUF814; pfam05670 637381005839 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381005840 NAD(P) binding site [chemical binding]; other site 637381005841 active site 637381005842 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 637381005843 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 637381005844 active site 637381005845 dimer interface [polypeptide binding]; other site 637381005846 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 637381005847 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 637381005848 heterodimer interface [polypeptide binding]; other site 637381005849 active site 637381005850 FMN binding site [chemical binding]; other site 637381005851 homodimer interface [polypeptide binding]; other site 637381005852 substrate binding site [chemical binding]; other site 637381005853 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 637381005854 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 637381005855 FAD binding pocket [chemical binding]; other site 637381005856 FAD binding motif [chemical binding]; other site 637381005857 phosphate binding motif [ion binding]; other site 637381005858 beta-alpha-beta structure motif; other site 637381005859 NAD binding pocket [chemical binding]; other site 637381005860 Iron coordination center [ion binding]; other site 637381005861 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 637381005862 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 637381005863 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 637381005864 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 637381005865 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 637381005866 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 637381005867 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 637381005868 IMP binding site; other site 637381005869 dimer interface [polypeptide binding]; other site 637381005870 interdomain contacts; other site 637381005871 partial ornithine binding site; other site 637381005872 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 637381005873 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 637381005874 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 637381005875 catalytic site [active] 637381005876 subunit interface [polypeptide binding]; other site 637381005877 dihydroorotase; Validated; Region: pyrC; PRK09357 637381005878 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 637381005879 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317 637381005880 active site 637381005881 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 637381005882 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 637381005883 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381005884 Sulfate transporter family; Region: Sulfate_transp; cl00967 637381005885 Permease family; Region: Xan_ur_permease; pfam00860 637381005886 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 637381005887 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 637381005888 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 637381005889 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637381005890 RNA binding surface [nucleotide binding]; other site 637381005891 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 637381005892 active site 637381005893 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 637381005894 Sulfate transporter family; Region: Sulfate_transp; cl00967 637381005895 Permease family; Region: Xan_ur_permease; pfam00860 637381005896 multidrug efflux protein; Reviewed; Region: PRK01766 637381005897 MatE; Region: MatE; cl10513 637381005898 MatE; Region: MatE; cl10513 637381005899 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 637381005900 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 637381005901 metal binding site [ion binding]; metal-binding site 637381005902 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 637381005903 ABC-ATPase subunit interface; other site 637381005904 dimer interface [polypeptide binding]; other site 637381005905 putative PBP binding regions; other site 637381005906 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 637381005907 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 637381005908 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381005909 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 637381005910 C-terminal peptidase (prc); Region: prc; TIGR00225 637381005911 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 637381005912 protein binding site [polypeptide binding]; other site 637381005913 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 637381005914 Catalytic dyad [active] 637381005915 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 637381005916 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 637381005917 metal-binding site [ion binding] 637381005918 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 637381005919 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 637381005920 metal-binding site [ion binding] 637381005921 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 637381005922 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637381005923 motif II; other site 637381005924 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 637381005925 putative homotetramer interface [polypeptide binding]; other site 637381005926 putative homodimer interface [polypeptide binding]; other site 637381005927 putative allosteric switch controlling residues; other site 637381005928 putative metal binding site [ion binding]; other site 637381005929 putative homodimer-homodimer interface [polypeptide binding]; other site 637381005930 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 637381005931 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 637381005932 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 637381005933 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 637381005934 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 637381005935 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 637381005936 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381005937 SelR domain; Region: SelR; cl00369 637381005938 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 637381005939 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 637381005940 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 637381005941 active site 637381005942 catalytic triad [active] 637381005943 oxyanion hole [active] 637381005944 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 637381005945 Haemolysin-III related; Region: HlyIII; cl03831 637381005946 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381005947 FOG: CBS domain [General function prediction only]; Region: COG0517 637381005948 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_4; cd04617 637381005949 Domain of unknown function (DUF299); Region: DUF299; cl00780 637381005950 pyruvate phosphate dikinase; Provisional; Region: PRK09279 637381005951 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 637381005952 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 637381005953 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 637381005954 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 637381005955 Predicted membrane protein [Function unknown]; Region: COG4129 637381005956 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 637381005957 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 637381005958 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 637381005959 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 637381005960 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 637381005961 active site 637381005962 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 637381005963 substrate binding site [chemical binding]; other site 637381005964 metal binding site [ion binding]; metal-binding site 637381005965 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 637381005966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637381005967 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209 637381005968 folate binding site [chemical binding]; other site 637381005969 NADP+ binding site [chemical binding]; other site 637381005970 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 637381005971 dimerization interface [polypeptide binding]; other site 637381005972 active site 637381005973 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 637381005974 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 637381005975 Walker A/P-loop; other site 637381005976 ATP binding site [chemical binding]; other site 637381005977 Q-loop/lid; other site 637381005978 ABC transporter signature motif; other site 637381005979 Walker B; other site 637381005980 D-loop; other site 637381005981 H-loop/switch region; other site 637381005982 ABC transporter; Region: ABC_tran_2; pfam12848 637381005983 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 637381005984 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 637381005985 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 637381005986 Potassium binding sites [ion binding]; other site 637381005987 Cesium cation binding sites [ion binding]; other site 637381005988 manganese transport transcriptional regulator; Provisional; Region: PRK03902 637381005989 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381005990 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 637381005991 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 637381005992 DNA-binding site [nucleotide binding]; DNA binding site 637381005993 RNA-binding motif; other site 637381005994 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 637381005995 RNA/DNA hybrid binding site [nucleotide binding]; other site 637381005996 active site 637381005997 5'-3' exonuclease; Region: 53EXOc; smart00475 637381005998 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 637381005999 active site 637381006000 metal binding site 1 [ion binding]; metal-binding site 637381006001 putative 5' ssDNA interaction site; other site 637381006002 metal binding site 3; metal-binding site 637381006003 metal binding site 2 [ion binding]; metal-binding site 637381006004 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 637381006005 putative DNA binding site [nucleotide binding]; other site 637381006006 putative metal binding site [ion binding]; other site 637381006007 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 637381006008 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18 (...; Region: GH18_chitinase_D-like; cd02871 637381006009 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 637381006010 putative active site [active] 637381006011 Permease family; Region: Xan_ur_permease; pfam00860 637381006012 Sulfate transporter family; Region: Sulfate_transp; cl00967 637381006013 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 637381006014 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 637381006015 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 637381006016 active site 637381006017 Zn binding site [ion binding]; other site 637381006018 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 637381006019 THUMP domain; Region: THUMP; cl12076 637381006020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637381006021 cell division protein GpsB; Provisional; Region: PRK14127 637381006022 DivIVA domain; Region: DivI1A_domain; TIGR03544 637381006023 Interactor of ZYG-11; Region: ZYG-11_interact; pfam05884 637381006024 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 637381006025 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 637381006026 Recombination protein U; Region: RecU; cl01314 637381006027 Transglycosylase; Region: Transgly; cl07896 637381006028 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 637381006029 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 637381006030 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 637381006031 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 637381006032 minor groove reading motif; other site 637381006033 helix-hairpin-helix signature motif; other site 637381006034 substrate binding pocket [chemical binding]; other site 637381006035 active site 637381006036 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 637381006037 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 637381006038 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 637381006039 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 637381006040 putative dimer interface [polypeptide binding]; other site 637381006041 putative anticodon binding site; other site 637381006042 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well...; Region: AsxRS_core; cd00776 637381006043 homodimer interface [polypeptide binding]; other site 637381006044 motif 1; other site 637381006045 motif 2; other site 637381006046 active site 637381006047 motif 3; other site 637381006048 hypothetical protein; Validated; Region: PRK07682 637381006049 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637381006050 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637381006051 homodimer interface [polypeptide binding]; other site 637381006052 catalytic residue [active] 637381006053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 637381006054 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 637381006055 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 637381006056 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 637381006057 active site 637381006058 substrate binding site [chemical binding]; other site 637381006059 catalytic site [active] 637381006060 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381006061 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381006062 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 637381006063 tetramerization interface [polypeptide binding]; other site 637381006064 active site 637381006065 pantoate--beta-alanine ligase; Region: panC; TIGR00018 637381006066 Pantoate-beta-alanine ligase; Region: PanC; cd00560 637381006067 active site 637381006068 ATP-binding site [chemical binding]; other site 637381006069 pantoate-binding site; other site 637381006070 HXXH motif; other site 637381006071 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 637381006072 active site 637381006073 oligomerization interface [polypeptide binding]; other site 637381006074 metal binding site [ion binding]; metal-binding site 637381006075 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 637381006076 catalytic residues [active] 637381006077 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381006078 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 637381006079 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 637381006080 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 637381006081 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 637381006082 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 637381006083 active site 637381006084 NTP binding site [chemical binding]; other site 637381006085 metal binding triad [ion binding]; metal-binding site 637381006086 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 637381006087 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 637381006088 active site 637381006089 dimer interfaces [polypeptide binding]; other site 637381006090 catalytic residues [active] 637381006091 dihydrodipicolinate reductase; Provisional; Region: PRK00048 637381006092 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381006093 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 637381006094 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 637381006095 Uncharacterized conserved protein [Function unknown]; Region: COG1284 637381006096 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 637381006097 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 637381006098 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 637381006099 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 637381006100 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 637381006101 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637381006102 metal binding site [ion binding]; metal-binding site 637381006103 active site 637381006104 I-site; other site 637381006105 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637381006106 metal binding site [ion binding]; metal-binding site 637381006107 active site 637381006108 I-site; other site 637381006109 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 637381006110 malate dehydrogenase; Provisional; Region: PRK13529 637381006111 Malic enzyme, N-terminal domain; Region: malic; pfam00390 637381006112 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381006113 NAD(P) binding pocket [chemical binding]; other site 637381006114 Beta-lactamase; Region: Beta-lactamase; cl01009 637381006115 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 637381006116 Pyruvate formate lyase 1; Region: PFL1; cd01678 637381006117 coenzyme A binding site [chemical binding]; other site 637381006118 active site 637381006119 catalytic residues [active] 637381006120 glycine loop; other site 637381006121 Predicted flavoproteins [General function prediction only]; Region: COG2081 637381006122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381006123 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 637381006124 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 637381006125 hypothetical protein; Provisional; Region: PRK03636 637381006126 UPF0302 domain; Region: UPF0302; pfam08864 637381006127 IDEAL domain; Region: IDEAL; cl07452 637381006128 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 637381006129 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 637381006130 binding surface 637381006131 TPR motif; other site 637381006132 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 637381006133 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 637381006134 hinge; other site 637381006135 active site 637381006136 prephenate dehydrogenase; Validated; Region: PRK06545 637381006137 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381006138 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 637381006139 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 637381006140 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637381006141 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637381006142 homodimer interface [polypeptide binding]; other site 637381006143 catalytic residue [active] 637381006144 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In...; Region: AroH; cd02185 637381006145 homotrimer interaction site [polypeptide binding]; other site 637381006146 active site 637381006147 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 637381006148 active site 637381006149 dimer interface [polypeptide binding]; other site 637381006150 metal binding site [ion binding]; metal-binding site 637381006151 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 637381006152 Tetramer interface [polypeptide binding]; other site 637381006153 Active site [active] 637381006154 FMN-binding site [chemical binding]; other site 637381006155 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 637381006156 active site 637381006157 multimer interface [polypeptide binding]; other site 637381006158 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 637381006159 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 637381006160 substrate binding pocket [chemical binding]; other site 637381006161 chain length determination region; other site 637381006162 substrate-Mg2+ binding site; other site 637381006163 catalytic residues [active] 637381006164 aspartate-rich region 1; other site 637381006165 active site lid residues [active] 637381006166 aspartate-rich region 2; other site 637381006167 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 637381006168 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637381006169 S-adenosylmethionine binding site [chemical binding]; other site 637381006170 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 637381006171 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 637381006172 homodecamer interface [polypeptide binding]; other site 637381006173 GTP cyclohydrolase I; Provisional; Region: PLN03044 637381006174 active site 637381006175 putative catalytic site residues [active] 637381006176 zinc binding site [ion binding]; other site 637381006177 GTP-CH-I/GFRP interaction surface; other site 637381006178 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 637381006179 IHF dimer interface [polypeptide binding]; other site 637381006180 IHF - DNA interface [nucleotide binding]; other site 637381006181 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 637381006182 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 637381006183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381006184 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 637381006185 GTP-binding protein Der; Reviewed; Region: PRK00093 637381006186 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 637381006187 G1 box; other site 637381006188 GTP/Mg2+ binding site [chemical binding]; other site 637381006189 Switch I region; other site 637381006190 G2 box; other site 637381006191 Switch II region; other site 637381006192 G3 box; other site 637381006193 G4 box; other site 637381006194 G5 box; other site 637381006195 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 637381006196 G1 box; other site 637381006197 GTP/Mg2+ binding site [chemical binding]; other site 637381006198 Switch I region; other site 637381006199 G2 box; other site 637381006200 G3 box; other site 637381006201 Switch II region; other site 637381006202 G4 box; other site 637381006203 G5 box; other site 637381006204 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 637381006205 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 637381006206 RNA binding site [nucleotide binding]; other site 637381006207 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 637381006208 RNA binding site [nucleotide binding]; other site 637381006209 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 637381006210 RNA binding site [nucleotide binding]; other site 637381006211 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 637381006212 RNA binding site [nucleotide binding]; other site 637381006213 cytidylate kinase; Provisional; Region: cmk; PRK00023 637381006214 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 637381006215 CMP-binding site; other site 637381006216 The sites determining sugar specificity; other site 637381006217 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 637381006218 active site 637381006219 homotetramer interface [polypeptide binding]; other site 637381006220 homodimer interface [polypeptide binding]; other site 637381006221 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 637381006222 putative peptidoglycan binding site; other site 637381006223 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637381006224 ATP binding site [chemical binding]; other site 637381006225 putative Mg++ binding site [ion binding]; other site 637381006226 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637381006227 nucleotide binding region [chemical binding]; other site 637381006228 ATP-binding site [chemical binding]; other site 637381006229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 637381006230 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 637381006231 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 637381006232 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 637381006233 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442 637381006234 proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785 637381006235 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 637381006236 dimerization interface [polypeptide binding]; other site 637381006237 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 637381006238 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637381006239 dimer interface [polypeptide binding]; other site 637381006240 phosphorylation site [posttranslational modification] 637381006241 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637381006242 ATP binding site [chemical binding]; other site 637381006243 Mg2+ binding site [ion binding]; other site 637381006244 G-X-G motif; other site 637381006245 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637381006246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637381006247 active site 637381006248 phosphorylation site [posttranslational modification] 637381006249 intermolecular recognition site; other site 637381006250 dimerization interface [polypeptide binding]; other site 637381006251 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637381006252 DNA binding site [nucleotide binding] 637381006253 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 637381006254 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637381006255 RNA binding surface [nucleotide binding]; other site 637381006256 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 637381006257 active site 637381006258 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 637381006259 ScpA/B protein; Region: ScpA_ScpB; cl00598 637381006260 diaminopimelate decarboxylase; Region: lysA; TIGR01048 637381006261 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 637381006262 active site 637381006263 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 637381006264 substrate binding site [chemical binding]; other site 637381006265 catalytic residues [active] 637381006266 dimer interface [polypeptide binding]; other site 637381006267 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 637381006268 Sulfatase; Region: Sulfatase; cl10460 637381006269 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 637381006270 N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid...; Region: INT_XerDC; cd00798 637381006271 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 637381006272 Int/Topo IB signature motif; other site 637381006273 active site 637381006274 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 637381006275 metal binding site 2 [ion binding]; metal-binding site 637381006276 putative DNA binding helix; other site 637381006277 metal binding site 1 [ion binding]; metal-binding site 637381006278 dimer interface [polypeptide binding]; other site 637381006279 structural Zn2+ binding site [ion binding]; other site 637381006280 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 637381006281 ABC-ATPase subunit interface; other site 637381006282 dimer interface [polypeptide binding]; other site 637381006283 putative PBP binding regions; other site 637381006284 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 637381006285 ABC-ATPase subunit interface; other site 637381006286 dimer interface [polypeptide binding]; other site 637381006287 putative PBP binding regions; other site 637381006288 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 637381006289 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: FeuA; cd01138 637381006290 putative ligand binding residues [chemical binding]; other site 637381006291 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 637381006292 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 637381006293 Walker A/P-loop; other site 637381006294 ATP binding site [chemical binding]; other site 637381006295 Q-loop/lid; other site 637381006296 ABC transporter signature motif; other site 637381006297 Walker B; other site 637381006298 D-loop; other site 637381006299 H-loop/switch region; other site 637381006300 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 637381006301 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381006302 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637381006303 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637381006304 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 637381006305 ABC-2 type transporter; Region: ABC2_membrane; cl11417 637381006306 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 637381006307 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 637381006308 Walker A/P-loop; other site 637381006309 ATP binding site [chemical binding]; other site 637381006310 Q-loop/lid; other site 637381006311 ABC transporter signature motif; other site 637381006312 Walker B; other site 637381006313 D-loop; other site 637381006314 H-loop/switch region; other site 637381006315 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 637381006316 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 637381006317 dimer interface [polypeptide binding]; other site 637381006318 ADP-ribose binding site [chemical binding]; other site 637381006319 active site 637381006320 nudix motif; other site 637381006321 metal binding site [ion binding]; metal-binding site 637381006322 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 637381006323 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 637381006324 Creatinine amidohydrolase; Region: Creatininase; cl00618 637381006325 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 637381006326 active site 637381006327 intersubunit interface [polypeptide binding]; other site 637381006328 catalytic residue [active] 637381006329 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: Php; COG1735 637381006330 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active...; Region: PTE; cd00530 637381006331 active site 637381006332 substrate binding pocket [chemical binding]; other site 637381006333 homodimer interaction site [polypeptide binding]; other site 637381006334 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 637381006335 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 637381006336 P-loop; other site 637381006337 active site 637381006338 phosphorylation site [posttranslational modification] 637381006339 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637381006340 active site 637381006341 phosphorylation site [posttranslational modification] 637381006342 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 637381006343 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637381006344 DNA-binding site [nucleotide binding]; DNA binding site 637381006345 UTRA domain; Region: UTRA; cl01230 637381006346 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 637381006347 active site 637381006348 DNA polymerase IV; Validated; Region: PRK02406 637381006349 DNA binding site [nucleotide binding] 637381006350 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 637381006351 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381006352 NAD(P) binding site [chemical binding]; other site 637381006353 active site 637381006354 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637381006355 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 637381006356 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 637381006357 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 637381006358 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 637381006359 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637381006360 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637381006361 Dehydratase family; Region: ILVD_EDD; cl00340 637381006362 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 637381006363 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 637381006364 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 637381006365 PYR/PP interface [polypeptide binding]; other site 637381006366 dimer interface [polypeptide binding]; other site 637381006367 TPP binding site [chemical binding]; other site 637381006368 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 637381006369 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 637381006370 TPP-binding site [chemical binding]; other site 637381006371 dimer interface [polypeptide binding]; other site 637381006372 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 637381006373 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 637381006374 putative valine binding site [chemical binding]; other site 637381006375 dimer interface [polypeptide binding]; other site 637381006376 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 637381006377 ketol-acid reductoisomerase; Provisional; Region: PRK05479 637381006378 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381006379 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 637381006380 2-isopropylmalate synthase; Validated; Region: PRK00915 637381006381 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 637381006382 active site 637381006383 catalytic residues [active] 637381006384 metal binding site [ion binding]; metal-binding site 637381006385 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 637381006386 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 637381006387 isocitrate dehydrogenase; Validated; Region: PRK06451 637381006388 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 637381006389 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 637381006390 substrate binding site [chemical binding]; other site 637381006391 ligand binding site [chemical binding]; other site 637381006392 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 637381006393 substrate binding site [chemical binding]; other site 637381006394 threonine dehydratase; Validated; Region: PRK08639 637381006395 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 637381006396 tetramer interface [polypeptide binding]; other site 637381006397 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637381006398 catalytic residue [active] 637381006399 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 637381006400 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 637381006401 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 637381006402 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 637381006403 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 637381006404 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 637381006405 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637381006406 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637381006407 DNA binding site [nucleotide binding] 637381006408 domain linker motif; other site 637381006409 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 637381006410 dimerization interface [polypeptide binding]; other site 637381006411 ligand binding site [chemical binding]; other site 637381006412 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 637381006413 intersubunit interface [polypeptide binding]; other site 637381006414 active site 637381006415 catalytic residue [active] 637381006416 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 637381006417 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381006418 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 637381006419 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006 637381006420 active pocket/dimerization site; other site 637381006421 active site 637381006422 phosphorylation site [posttranslational modification] 637381006423 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 637381006424 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 637381006425 putative active site [active] 637381006426 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 637381006427 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 637381006428 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 637381006429 dimer interface [polypeptide binding]; other site 637381006430 active site 637381006431 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 637381006432 dimer interface [polypeptide binding]; other site 637381006433 active site 637381006434 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 637381006435 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 637381006436 Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four...; Region: PTS_IIB_man; cd00001 637381006437 active site 637381006438 phosphorylation site [posttranslational modification] 637381006439 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 637381006440 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637381006441 DNA-binding site [nucleotide binding]; DNA binding site 637381006442 UTRA domain; Region: UTRA; cl01230 637381006443 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 637381006444 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637381006445 DNA-binding site [nucleotide binding]; DNA binding site 637381006446 UTRA domain; Region: UTRA; cl01230 637381006447 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 637381006448 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 637381006449 active site 637381006450 catalytic tetrad [active] 637381006451 acetolactate synthase; Reviewed; Region: PRK08617 637381006452 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 637381006453 PYR/PP interface [polypeptide binding]; other site 637381006454 dimer interface [polypeptide binding]; other site 637381006455 TPP binding site [chemical binding]; other site 637381006456 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 637381006457 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 637381006458 TPP-binding site [chemical binding]; other site 637381006459 dimer interface [polypeptide binding]; other site 637381006460 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637381006461 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 637381006462 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 637381006463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381006464 dimer interface [polypeptide binding]; other site 637381006465 conserved gate region; other site 637381006466 ABC-ATPase subunit interface; other site 637381006467 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 637381006468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381006469 dimer interface [polypeptide binding]; other site 637381006470 conserved gate region; other site 637381006471 ABC-ATPase subunit interface; other site 637381006472 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 637381006473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637381006474 active site 637381006475 phosphorylation site [posttranslational modification] 637381006476 intermolecular recognition site; other site 637381006477 dimerization interface [polypeptide binding]; other site 637381006478 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637381006479 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 637381006480 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 637381006481 Histidine kinase; Region: His_kinase; pfam06580 637381006482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637381006483 ATP binding site [chemical binding]; other site 637381006484 Mg2+ binding site [ion binding]; other site 637381006485 G-X-G motif; other site 637381006486 Protein of unknown function, DUF624; Region: DUF624; cl02369 637381006487 Uncharacterized conserved protein [Function unknown]; Region: COG3538 637381006488 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 637381006489 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 637381006490 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 637381006491 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 637381006492 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 637381006493 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 637381006494 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 637381006495 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 637381006496 DNA-binding site [nucleotide binding]; DNA binding site 637381006497 RNA-binding motif; other site 637381006498 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 637381006499 active site 637381006500 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 637381006501 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 637381006502 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 637381006503 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 637381006504 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 637381006505 HIGH motif; other site 637381006506 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 637381006507 active site 637381006508 KMSKS motif; other site 637381006509 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 637381006510 tRNA binding surface [nucleotide binding]; other site 637381006511 anticodon binding site; other site 637381006512 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 637381006513 DivIVA protein; Region: DivIVA; pfam05103 637381006514 DivIVA domain; Region: DivI1A_domain; TIGR03544 637381006515 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 637381006516 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381006517 3H domain; Region: 3H; pfam02829 637381006518 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 637381006519 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 637381006520 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637381006521 catalytic residue [active] 637381006522 L-aspartate oxidase; Provisional; Region: PRK08071 637381006523 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381006524 domain; Region: Succ_DH_flav_C; pfam02910 637381006525 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 637381006526 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572 637381006527 dimerization interface [polypeptide binding]; other site 637381006528 active site 637381006529 Quinolinate synthetase A protein; Region: NadA; cl00420 637381006530 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 637381006531 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637381006532 RNA binding surface [nucleotide binding]; other site 637381006533 YGGT family; Region: YGGT; cl00508 637381006534 Protein of unknown function (DUF552); Region: DUF552; cl00775 637381006535 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 637381006536 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 637381006537 catalytic residue [active] 637381006538 cell division protein FtsZ; Validated; Region: PRK09330 637381006539 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 637381006540 nucleotide binding site [chemical binding]; other site 637381006541 SulA interaction site; other site 637381006542 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 637381006543 Cell division protein FtsA; Region: FtsA; cl11496 637381006544 Cell division protein FtsA; Region: FtsA; cl11496 637381006545 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 637381006546 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 637381006547 Cell division protein FtsQ; Region: FtsQ; pfam03799 637381006548 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 637381006549 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 637381006550 active site 637381006551 homodimer interface [polypeptide binding]; other site 637381006552 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 637381006553 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637381006554 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637381006555 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 637381006556 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 637381006557 Mg++ binding site [ion binding]; other site 637381006558 putative catalytic motif [active] 637381006559 putative substrate binding site [chemical binding]; other site 637381006560 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 637381006561 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 637381006562 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637381006563 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637381006564 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 637381006565 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 637381006566 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 637381006567 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 637381006568 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 637381006569 Septum formation initiator; Region: DivIC; cl11433 637381006570 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 637381006571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637381006572 cell division protein MraZ; Reviewed; Region: PRK00326 637381006573 MraZ protein; Region: MraZ; pfam02381 637381006574 MraZ protein; Region: MraZ; pfam02381 637381006575 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637381006576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637381006577 putative substrate translocation pore; other site 637381006578 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 637381006579 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 637381006580 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 637381006581 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 637381006582 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381006583 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 637381006584 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 637381006585 hypothetical protein; Provisional; Region: PRK13670 637381006586 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 637381006587 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 637381006588 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 637381006589 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 637381006590 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381006591 Walker A/P-loop; other site 637381006592 ATP binding site [chemical binding]; other site 637381006593 Q-loop/lid; other site 637381006594 ABC transporter signature motif; other site 637381006595 Walker B; other site 637381006596 D-loop; other site 637381006597 H-loop/switch region; other site 637381006598 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 637381006599 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 637381006600 protein binding site [polypeptide binding]; other site 637381006601 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 637381006602 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 637381006603 active site 637381006604 (T/H)XGH motif; other site 637381006605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637381006606 S-adenosylmethionine binding site [chemical binding]; other site 637381006607 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 637381006608 Protein of unknown function (DUF964); Region: DUF964; cl01483 637381006609 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 637381006610 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 637381006611 UbiA prenyltransferase family; Region: UbiA; cl00337 637381006612 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 637381006613 cytochrome c oxidase assembly protein; Provisional; Region: PTZ00127 637381006614 Ion transport protein; Region: Ion_trans; pfam00520 637381006615 Ion channel; Region: Ion_trans_2; cl11596 637381006616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 637381006617 MOSC domain; Region: MOSC; pfam03473 637381006618 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 637381006619 Copper resistance protein CopC; Region: CopC; cl01012 637381006620 Copper resistance protein D; Region: CopD; cl00563 637381006621 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 637381006622 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 637381006623 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-...; Region: Ntn_PVA; cd00542 637381006624 active site 637381006625 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 637381006626 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 637381006627 ring oligomerisation interface [polypeptide binding]; other site 637381006628 ATP/Mg binding site [chemical binding]; other site 637381006629 stacking interactions; other site 637381006630 hinge regions; other site 637381006631 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 637381006632 oligomerisation interface [polypeptide binding]; other site 637381006633 mobile loop; other site 637381006634 roof hairpin; other site 637381006635 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 637381006636 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 637381006637 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 637381006638 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381006639 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 637381006640 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 637381006641 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381006642 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 637381006643 ABC transporter; Region: ABC_tran_2; pfam12848 637381006644 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 637381006645 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637381006646 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 637381006647 UGMP family protein; Validated; Region: PRK09604 637381006648 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 637381006649 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 637381006650 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637381006651 Coenzyme A binding pocket [chemical binding]; other site 637381006652 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 637381006653 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 637381006654 CrcB-like protein; Region: CRCB; cl09114 637381006655 CrcB-like protein; Region: CRCB; cl09114 637381006656 Uncharacterized conserved protein [Function unknown]; Region: COG4832 637381006657 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 637381006658 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 637381006659 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 637381006660 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 637381006661 active site 637381006662 substrate binding site [chemical binding]; other site 637381006663 ATP binding site [chemical binding]; other site 637381006664 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637381006665 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637381006666 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637381006667 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637381006668 non-specific DNA binding site [nucleotide binding]; other site 637381006669 salt bridge; other site 637381006670 sequence-specific DNA binding site [nucleotide binding]; other site 637381006671 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 637381006672 MatE; Region: MatE; cl10513 637381006673 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637381006674 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637381006675 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637381006676 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 637381006677 substrate binding pocket [chemical binding]; other site 637381006678 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 637381006679 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 637381006680 ANP binding site [chemical binding]; other site 637381006681 Substrate Binding Site II [chemical binding]; other site 637381006682 Substrate Binding Site I [chemical binding]; other site 637381006683 argininosuccinate lyase; Provisional; Region: PRK00855 637381006684 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 637381006685 active sites [active] 637381006686 tetramer interface [polypeptide binding]; other site 637381006687 BCCT family transporter; Region: BCCT; cl00569 637381006688 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 637381006689 active site 637381006690 intersubunit interface [polypeptide binding]; other site 637381006691 Zn2+ binding site [ion binding]; other site 637381006692 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 637381006693 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 637381006694 putative substrate binding site [chemical binding]; other site 637381006695 putative ATP binding site [chemical binding]; other site 637381006696 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 637381006697 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 637381006698 P-loop; other site 637381006699 active site 637381006700 phosphorylation site [posttranslational modification] 637381006701 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637381006702 active site 637381006703 phosphorylation site [posttranslational modification] 637381006704 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 637381006705 PRD domain; Region: PRD; pfam00874 637381006706 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 637381006707 P-loop; other site 637381006708 active site 637381006709 phosphorylation site [posttranslational modification] 637381006710 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 637381006711 active site 637381006712 phosphorylation site [posttranslational modification] 637381006713 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 637381006714 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637381006715 DNA-binding site [nucleotide binding]; DNA binding site 637381006716 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637381006717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637381006718 homodimer interface [polypeptide binding]; other site 637381006719 catalytic residue [active] 637381006720 pyridoxal biosynthesis lyase PdxS; Provisional; Region: PRK04180 637381006721 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 637381006722 active site 637381006723 multimer interface [polypeptide binding]; other site 637381006724 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 637381006725 conserved cys residue [active] 637381006726 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 637381006727 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 637381006728 FeoA domain; Region: FeoA; cl00838 637381006729 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 637381006730 Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this...; Region: FeoB; cd01879 637381006731 G1 box; other site 637381006732 GTP/Mg2+ binding site [chemical binding]; other site 637381006733 Switch I region; other site 637381006734 G2 box; other site 637381006735 G3 box; other site 637381006736 Switch II region; other site 637381006737 G4 box; other site 637381006738 G5 box; other site 637381006739 Nucleoside recognition; Region: Gate; cl00486 637381006740 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 637381006741 Nucleoside recognition; Region: Gate; cl00486 637381006742 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 637381006743 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 637381006744 putative active site [active] 637381006745 putative metal binding site [ion binding]; other site 637381006746 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 637381006747 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381006748 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 637381006749 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 637381006750 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 637381006751 active site 637381006752 dimer interface [polypeptide binding]; other site 637381006753 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 637381006754 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 637381006755 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 637381006756 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH...; Region: NfsA_FRP; cd02146 637381006757 dimer interface [polypeptide binding]; other site 637381006758 FMN binding site [chemical binding]; other site 637381006759 NADPH bind site [chemical binding]; other site 637381006760 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 637381006761 Chlorite dismutase; Region: Chlor_dismutase; cl01280 637381006762 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637381006763 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 637381006764 Walker A/P-loop; other site 637381006765 ATP binding site [chemical binding]; other site 637381006766 Q-loop/lid; other site 637381006767 ABC transporter signature motif; other site 637381006768 Walker B; other site 637381006769 D-loop; other site 637381006770 H-loop/switch region; other site 637381006771 FtsX-like permease family; Region: FtsX; pfam02687 637381006772 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637381006773 Coenzyme A binding pocket [chemical binding]; other site 637381006774 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 637381006775 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 637381006776 active site 637381006777 substrate binding site [chemical binding]; other site 637381006778 metal binding site [ion binding]; metal-binding site 637381006779 YbbR-like protein; Region: YbbR; pfam07949 637381006780 YbbR-like protein; Region: YbbR; pfam07949 637381006781 YbbR-like protein; Region: YbbR; pfam07949 637381006782 Uncharacterized conserved protein [Function unknown]; Region: COG1624 637381006783 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 637381006784 maltose phosphorylase; Provisional; Region: PRK13807 637381006785 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 637381006786 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 637381006787 Predicted integral membrane protein [Function unknown]; Region: COG5521 637381006788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381006789 dimer interface [polypeptide binding]; other site 637381006790 conserved gate region; other site 637381006791 putative PBP binding loops; other site 637381006792 ABC-ATPase subunit interface; other site 637381006793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381006794 dimer interface [polypeptide binding]; other site 637381006795 conserved gate region; other site 637381006796 putative PBP binding loops; other site 637381006797 ABC-ATPase subunit interface; other site 637381006798 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 637381006799 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637381006800 CD and pullulan-degrading enzymes N-terminus domain. Members of this subgroup include: Cyclomaltodextrinase (CDase), maltogenic amylase, and neopullulanase all of which are capable of hydrolyzing all or two of the following three types of substrates:...; Region: CD_pullulan_degrading_enzymes_N_term; cd02857 637381006801 homodimer; other site 637381006802 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 637381006803 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 637381006804 CAAX amino terminal protease family; Region: Abi; cl00558 637381006805 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637381006806 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637381006807 DNA binding site [nucleotide binding] 637381006808 domain linker motif; other site 637381006809 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 637381006810 ligand binding site [chemical binding]; other site 637381006811 dimerization interface [polypeptide binding]; other site 637381006812 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637381006813 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 637381006814 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 637381006815 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 637381006816 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 637381006817 ligand binding site [chemical binding]; other site 637381006818 flexible hinge region; other site 637381006819 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381006820 hypothetical protein; Provisional; Region: PRK08185 637381006821 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 637381006822 intersubunit interface [polypeptide binding]; other site 637381006823 active site 637381006824 zinc binding site [ion binding]; other site 637381006825 Na+ binding site [ion binding]; other site 637381006826 hypothetical protein; Provisional; Region: PRK08185 637381006827 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 637381006828 intersubunit interface [polypeptide binding]; other site 637381006829 active site 637381006830 zinc binding site [ion binding]; other site 637381006831 Na+ binding site [ion binding]; other site 637381006832 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637381006833 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 637381006834 P-loop; other site 637381006835 active site 637381006836 phosphorylation site [posttranslational modification] 637381006837 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637381006838 active site 637381006839 phosphorylation site [posttranslational modification] 637381006840 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 637381006841 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381006842 PRD domain; Region: PRD; pfam00874 637381006843 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 637381006844 P-loop; other site 637381006845 active site 637381006846 phosphorylation site [posttranslational modification] 637381006847 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 637381006848 This subfamily is involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity. In eubacteria and archaea, the typical organization consists of one ABC and one or two IMs. Eukaryote systems of the ABCA subfamily...; Region: ABC_putative_ATPase; cd03269 637381006849 Walker A/P-loop; other site 637381006850 ATP binding site [chemical binding]; other site 637381006851 Q-loop/lid; other site 637381006852 ABC transporter signature motif; other site 637381006853 Walker B; other site 637381006854 D-loop; other site 637381006855 H-loop/switch region; other site 637381006856 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 637381006857 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637381006858 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637381006859 Coenzyme A binding pocket [chemical binding]; other site 637381006860 Transcriptional regulators [Transcription]; Region: GntR; COG1802 637381006861 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 637381006862 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 637381006863 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 637381006864 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 637381006865 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637381006866 DNA-binding site [nucleotide binding]; DNA binding site 637381006867 UTRA domain; Region: UTRA; cl01230 637381006868 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637381006869 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637381006870 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381006871 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 637381006872 putative dimerization interface [polypeptide binding]; other site 637381006873 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 637381006874 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 637381006875 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 637381006876 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 637381006877 catalytic residues [active] 637381006878 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 637381006879 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 637381006880 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 637381006881 dimer interface [polypeptide binding]; other site 637381006882 putative radical transfer pathway; other site 637381006883 diiron center [ion binding]; other site 637381006884 tyrosyl radical; other site 637381006885 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 637381006886 Class I ribonucleotide reductase; Region: RNR_I; cd01679 637381006887 active site 637381006888 dimer interface [polypeptide binding]; other site 637381006889 catalytic residues [active] 637381006890 effector binding site; other site 637381006891 R2 peptide binding site; other site 637381006892 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 637381006893 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 637381006894 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637381006895 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 637381006896 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381006897 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 637381006898 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 637381006899 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 637381006900 DNA interaction; other site 637381006901 Metal-binding active site; metal-binding site 637381006902 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 637381006903 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 637381006904 conserved cys residue [active] 637381006905 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 637381006906 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 637381006907 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381006908 Cupin domain; Region: Cupin_2; cl09118 637381006909 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637381006910 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637381006911 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 637381006912 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 637381006913 ligand binding site [chemical binding]; other site 637381006914 flexible hinge region; other site 637381006915 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637381006916 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 637381006917 dimer interface [polypeptide binding]; other site 637381006918 active site 637381006919 metal binding site [ion binding]; metal-binding site 637381006920 glutathione binding site [chemical binding]; other site 637381006921 putative enoyl-(acyl-carrier-protein) reductase II; Region: enACPred_II; TIGR03151 637381006922 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 637381006923 FMN binding site [chemical binding]; other site 637381006924 substrate binding site [chemical binding]; other site 637381006925 putative catalytic residue [active] 637381006926 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 637381006927 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 637381006928 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 637381006929 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 637381006930 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 637381006931 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637381006932 Walker A motif; other site 637381006933 ATP binding site [chemical binding]; other site 637381006934 Walker B motif; other site 637381006935 arginine finger; other site 637381006936 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 637381006937 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 637381006938 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637381006939 metal binding site [ion binding]; metal-binding site 637381006940 active site 637381006941 I-site; other site 637381006942 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 637381006943 classical (c) SDRs; Region: SDR_c; cd05233 637381006944 NAD(P) binding site [chemical binding]; other site 637381006945 active site 637381006946 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637381006947 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637381006948 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 637381006949 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637381006950 Collagen binding domain; Region: Collagen_bind; pfam05737 637381006951 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637381006952 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637381006953 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637381006954 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637381006955 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637381006956 MucBP domain; Region: MucBP; pfam06458 637381006957 MucBP domain; Region: MucBP; pfam06458 637381006958 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 637381006959 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 637381006960 active site 637381006961 catalytic site [active] 637381006962 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 637381006963 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 637381006964 Walker A/P-loop; other site 637381006965 ATP binding site [chemical binding]; other site 637381006966 Q-loop/lid; other site 637381006967 ABC transporter signature motif; other site 637381006968 Walker B; other site 637381006969 D-loop; other site 637381006970 H-loop/switch region; other site 637381006971 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 637381006972 ABC-ATPase subunit interface; other site 637381006973 dimer interface [polypeptide binding]; other site 637381006974 putative PBP binding regions; other site 637381006975 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 637381006976 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 637381006977 putative ligand binding residues [chemical binding]; other site 637381006978 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 637381006979 heme-binding site [chemical binding]; other site 637381006980 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 637381006981 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 637381006982 heme-binding site [chemical binding]; other site 637381006983 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 637381006984 heme-binding site [chemical binding]; other site 637381006985 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 637381006986 heme uptake protein IsdC; Region: IsdC; TIGR03656 637381006987 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 637381006988 heme-binding site [chemical binding]; other site 637381006989 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 637381006990 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 637381006991 oligoendopeptidase F; Region: pepF; TIGR00181 637381006992 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 637381006993 active site 637381006994 Zn binding site [ion binding]; other site 637381006995 Competence protein CoiA-like family; Region: CoiA; cl11541 637381006996 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 637381006997 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting...; Region: ArsC_Spx; cd03032 637381006998 putative catalytic residues [active] 637381006999 thiol/disulfide switch; other site 637381007000 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 637381007001 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 637381007002 Walker A/P-loop; other site 637381007003 ATP binding site [chemical binding]; other site 637381007004 Q-loop/lid; other site 637381007005 ABC transporter signature motif; other site 637381007006 Walker B; other site 637381007007 D-loop; other site 637381007008 H-loop/switch region; other site 637381007009 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 637381007010 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 637381007011 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 637381007012 Walker A/P-loop; other site 637381007013 ATP binding site [chemical binding]; other site 637381007014 Q-loop/lid; other site 637381007015 ABC transporter signature motif; other site 637381007016 Walker B; other site 637381007017 D-loop; other site 637381007018 H-loop/switch region; other site 637381007019 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 637381007020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381007021 dimer interface [polypeptide binding]; other site 637381007022 conserved gate region; other site 637381007023 putative PBP binding loops; other site 637381007024 ABC-ATPase subunit interface; other site 637381007025 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 637381007026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381007027 dimer interface [polypeptide binding]; other site 637381007028 conserved gate region; other site 637381007029 putative PBP binding loops; other site 637381007030 ABC-ATPase subunit interface; other site 637381007031 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 637381007032 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 637381007033 peptide binding site [polypeptide binding]; other site 637381007034 tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233 637381007035 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 637381007036 active site 637381007037 HIGH motif; other site 637381007038 dimer interface [polypeptide binding]; other site 637381007039 KMSKS motif; other site 637381007040 OsmC-like protein; Region: OsmC; cl00767 637381007041 Transcriptional regulators [Transcription]; Region: MarR; COG1846 637381007042 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381007043 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 637381007044 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 637381007045 dimer interface [polypeptide binding]; other site 637381007046 active site 637381007047 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 637381007048 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 637381007049 dimer interface [polypeptide binding]; other site 637381007050 active site 637381007051 CoA binding pocket [chemical binding]; other site 637381007052 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 637381007053 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 637381007054 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 637381007055 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637381007056 catalytic core [active] 637381007057 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637381007058 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 637381007059 Clp amino terminal domain; Region: Clp_N; pfam02861 637381007060 Clp amino terminal domain; Region: Clp_N; pfam02861 637381007061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637381007062 Walker A motif; other site 637381007063 ATP binding site [chemical binding]; other site 637381007064 Walker B motif; other site 637381007065 arginine finger; other site 637381007066 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637381007067 Walker A motif; other site 637381007068 ATP binding site [chemical binding]; other site 637381007069 Walker B motif; other site 637381007070 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 637381007071 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 637381007072 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 637381007073 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637381007074 active site 637381007075 motif I; other site 637381007076 motif II; other site 637381007077 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637381007078 Predicted acetyltransferase [General function prediction only]; Region: COG3393 637381007079 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637381007080 ferrochelatase; Provisional; Region: PRK12435 637381007081 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 637381007082 C-terminal domain interface [polypeptide binding]; other site 637381007083 active site 637381007084 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 637381007085 active site 637381007086 N-terminal domain interface [polypeptide binding]; other site 637381007087 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 637381007088 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717 637381007089 substrate binding site [chemical binding]; other site 637381007090 active site 637381007091 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 637381007092 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 637381007093 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 637381007094 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 637381007095 Walker A/P-loop; other site 637381007096 ATP binding site [chemical binding]; other site 637381007097 Q-loop/lid; other site 637381007098 ABC transporter signature motif; other site 637381007099 Walker B; other site 637381007100 D-loop; other site 637381007101 H-loop/switch region; other site 637381007102 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life...; Region: HINT_subgroup; cd01277 637381007103 HIT family signature motif; other site 637381007104 catalytic residue [active] 637381007105 YtxH-like protein; Region: YtxH; cl02079 637381007106 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 637381007107 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 637381007108 PPIC-type PPIASE domain; Region: Rotamase; cl08278 637381007109 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 637381007110 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 637381007111 generic binding surface II; other site 637381007112 generic binding surface I; other site 637381007113 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 637381007114 Uncharacterized conserved protein [Function unknown]; Region: COG4717 637381007115 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 637381007116 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 637381007117 active site 637381007118 metal binding site [ion binding]; metal-binding site 637381007119 DNA binding site [nucleotide binding] 637381007120 Protein of unknown function (DUF964); Region: DUF964; cl01483 637381007121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 637381007122 fumarate hydratase; Reviewed; Region: fumC; PRK00485 637381007123 Class II fumarases; Region: Fumarase_classII; cd01362 637381007124 active site 637381007125 tetramer interface [polypeptide binding]; other site 637381007126 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 637381007127 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 637381007128 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381007129 Walker A/P-loop; other site 637381007130 ATP binding site [chemical binding]; other site 637381007131 Q-loop/lid; other site 637381007132 ABC transporter signature motif; other site 637381007133 Walker B; other site 637381007134 D-loop; other site 637381007135 H-loop/switch region; other site 637381007136 Transglycosylase; Region: Transgly; cl07896 637381007137 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 637381007138 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 637381007139 Low molecular weight phosphatase family; Region: LMWPc; cl00105 637381007140 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 637381007141 Cation efflux family; Region: Cation_efflux; cl00316 637381007142 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 637381007143 Domain of unknown function DUF21; Region: DUF21; pfam01595 637381007144 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 637381007145 Transporter associated domain; Region: CorC_HlyC; cl08393 637381007146 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637381007147 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381007148 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 637381007149 putative dimerization interface [polypeptide binding]; other site 637381007150 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 637381007151 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 637381007152 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as...; Region: OYE_like_FMN_family; cd02803 637381007153 active site 637381007154 FMN binding site [chemical binding]; other site 637381007155 substrate binding site [chemical binding]; other site 637381007156 putative catalytic residue [active] 637381007157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381007158 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 637381007159 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 637381007160 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 637381007161 shikimate binding site; other site 637381007162 NAD(P) binding site [chemical binding]; other site 637381007163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637381007164 putative substrate translocation pore; other site 637381007165 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637381007166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637381007167 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637381007168 putative substrate translocation pore; other site 637381007169 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 637381007170 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 637381007171 Walker A/P-loop; other site 637381007172 ATP binding site [chemical binding]; other site 637381007173 Q-loop/lid; other site 637381007174 ABC transporter signature motif; other site 637381007175 Walker B; other site 637381007176 D-loop; other site 637381007177 H-loop/switch region; other site 637381007178 Predicted transcriptional regulators [Transcription]; Region: COG1725 637381007179 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637381007180 DNA-binding site [nucleotide binding]; DNA binding site 637381007181 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 637381007182 DNA binding site [nucleotide binding] 637381007183 active site 637381007184 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 637381007185 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 637381007186 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637381007187 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637381007188 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 637381007189 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 637381007190 active site 637381007191 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 637381007192 putative dimer interface [polypeptide binding]; other site 637381007193 ligand binding site [chemical binding]; other site 637381007194 Zn binding site [ion binding]; other site 637381007195 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 637381007196 Active site [active] 637381007197 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 637381007198 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637381007199 active site 637381007200 catalytic tetrad [active] 637381007201 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 637381007202 Phosphate transporter family; Region: PHO4; cl00396 637381007203 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 637381007204 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 637381007205 substrate binding pocket [chemical binding]; other site 637381007206 membrane-bound complex binding site; other site 637381007207 hinge residues; other site 637381007208 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 637381007209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381007210 dimer interface [polypeptide binding]; other site 637381007211 conserved gate region; other site 637381007212 putative PBP binding loops; other site 637381007213 ABC-ATPase subunit interface; other site 637381007214 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 637381007215 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 637381007216 Walker A/P-loop; other site 637381007217 ATP binding site [chemical binding]; other site 637381007218 Q-loop/lid; other site 637381007219 ABC transporter signature motif; other site 637381007220 Walker B; other site 637381007221 D-loop; other site 637381007222 H-loop/switch region; other site 637381007223 hypothetical protein; Validated; Region: PRK07682 637381007224 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637381007225 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637381007226 homodimer interface [polypeptide binding]; other site 637381007227 catalytic residue [active] 637381007228 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 637381007229 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637381007230 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637381007231 motif II; other site 637381007232 Sulfate transporter family; Region: Sulfate_transp; cl00967 637381007233 Permease family; Region: Xan_ur_permease; pfam00860 637381007234 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 637381007235 proposed catalytic triad [active] 637381007236 conserved cys residue [active] 637381007237 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 637381007238 methionine cluster; other site 637381007239 active site 637381007240 phosphorylation site [posttranslational modification] 637381007241 metal binding site [ion binding]; metal-binding site 637381007242 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637381007243 Coenzyme A binding pocket [chemical binding]; other site 637381007244 Domain of unknown function DUF59; Region: DUF59; cl00941 637381007245 esterase; Provisional; Region: PRK10566 637381007246 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637381007247 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 637381007248 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637381007249 motif II; other site 637381007250 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637381007251 Uncharacterized conserved protein [Function unknown]; Region: COG1284 637381007252 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 637381007253 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 637381007254 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 637381007255 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 637381007256 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 637381007257 helicase-exonuclease AddAB, AddA subunit; Region: addA_Gpos; TIGR02785 637381007258 UvrD/REP helicase; Region: UvrD-helicase; cl14126 637381007259 UvrD/REP helicase; Region: UvrD-helicase; cl14126 637381007260 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 637381007261 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 637381007262 UvrD/REP helicase; Region: UvrD-helicase; cl14126 637381007263 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 637381007264 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 637381007265 IDEAL domain; Region: IDEAL; cl07452 637381007266 ComK protein; Region: ComK; cl11560 637381007267 DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor...; Region: AP2; cl00033 637381007268 Domain of unknown function (DUF3825); Region: DUF3825; pfam12873 637381007269 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 637381007270 Phage holin; Region: Phage_holin_5; pfam06946 637381007271 Protein gp23 (Bacteriophage A118); Region: Phage_Gp23; pfam10669 637381007272 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 637381007273 Phage tail protein; Region: Sipho_tail; cl11462 637381007274 Phage-related tail protein [Function unknown]; Region: COG5283 637381007275 Phage-related tail protein [Function unknown]; Region: COG5283 637381007276 Phage-related protein [Function unknown]; Region: COG5412 637381007277 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 637381007278 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 637381007279 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 637381007280 Phage terminase large subunit; Region: Terminase_3; cl12054 637381007281 Terminase-like family; Region: Terminase_6; pfam03237 637381007282 Uncharacterized conserved protein [Function unknown]; Region: COG5484 637381007283 Phage terminase small subunit; Region: Phage_terminase; pfam10668 637381007284 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 637381007285 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; cl05448 637381007286 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 637381007287 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 637381007288 dimer interface [polypeptide binding]; other site 637381007289 ssDNA binding site [nucleotide binding]; other site 637381007290 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637381007291 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation...; Region: ASCH; cl01020 637381007292 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889 637381007293 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 637381007294 ERF superfamily; Region: ERF; pfam04404 637381007295 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 637381007296 Protein gp45 of Bacteriophage A118; Region: Phage-A118_gp45; pfam10653 637381007297 AntA/AntB antirepressor; Region: AntA; cl01430 637381007298 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 637381007299 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 637381007300 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637381007301 non-specific DNA binding site [nucleotide binding]; other site 637381007302 salt bridge; other site 637381007303 sequence-specific DNA binding site [nucleotide binding]; other site 637381007304 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637381007305 non-specific DNA binding site [nucleotide binding]; other site 637381007306 salt bridge; other site 637381007307 sequence-specific DNA binding site [nucleotide binding]; other site 637381007308 Domain of unknown function (DUF955); Region: DUF955; cl01076 637381007309 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 637381007310 Divergent AAA domain; Region: AAA_4; pfam04326 637381007311 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 637381007312 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 637381007313 catalytic residues [active] 637381007314 catalytic nucleophile [active] 637381007315 Presynaptic Site I dimer interface [polypeptide binding]; other site 637381007316 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 637381007317 Synaptic Flat tetramer interface [polypeptide binding]; other site 637381007318 Synaptic Site I dimer interface [polypeptide binding]; other site 637381007319 DNA binding site [nucleotide binding] 637381007320 Recombinase; Region: Recombinase; pfam07508 637381007321 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637381007322 non-specific DNA binding site [nucleotide binding]; other site 637381007323 salt bridge; other site 637381007324 sequence-specific DNA binding site [nucleotide binding]; other site 637381007325 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 637381007326 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637381007327 active site 637381007328 phosphorylation site [posttranslational modification] 637381007329 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 637381007330 P-loop; other site 637381007331 active site 637381007332 phosphorylation site [posttranslational modification] 637381007333 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637381007334 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 637381007335 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 637381007336 putative substrate binding site [chemical binding]; other site 637381007337 putative ATP binding site [chemical binding]; other site 637381007338 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 637381007339 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381007340 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 637381007341 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH...; Region: Peptidase_C1B; cd00585 637381007342 trimer interface [polypeptide binding]; other site 637381007343 active site 637381007344 G bulge; other site 637381007345 Protein of unknown function (DUF523); Region: DUF523; cl00733 637381007346 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 637381007347 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381007348 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 637381007349 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 637381007350 substrate binding site [chemical binding]; other site 637381007351 ATP binding site [chemical binding]; other site 637381007352 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 637381007353 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637381007354 RNA binding surface [nucleotide binding]; other site 637381007355 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 637381007356 active site 637381007357 uracil binding [chemical binding]; other site 637381007358 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 637381007359 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 637381007360 active site 637381007361 non-prolyl cis peptide bond; other site 637381007362 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976 637381007363 catalytic residues [active] 637381007364 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 637381007365 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 637381007366 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 637381007367 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 637381007368 Walker A/P-loop; other site 637381007369 ATP binding site [chemical binding]; other site 637381007370 Q-loop/lid; other site 637381007371 ABC transporter signature motif; other site 637381007372 Walker B; other site 637381007373 D-loop; other site 637381007374 H-loop/switch region; other site 637381007375 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 637381007376 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381007377 dimer interface [polypeptide binding]; other site 637381007378 conserved gate region; other site 637381007379 putative PBP binding loops; other site 637381007380 ABC-ATPase subunit interface; other site 637381007381 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 637381007382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381007383 dimer interface [polypeptide binding]; other site 637381007384 conserved gate region; other site 637381007385 putative PBP binding loops; other site 637381007386 ABC-ATPase subunit interface; other site 637381007387 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 637381007388 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 637381007389 substrate binding pocket [chemical binding]; other site 637381007390 membrane-bound complex binding site; other site 637381007391 hinge residues; other site 637381007392 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637381007393 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 637381007394 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637381007395 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381007396 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 637381007397 dimerization interface [polypeptide binding]; other site 637381007398 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 637381007399 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 637381007400 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 637381007401 active site 637381007402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637381007403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637381007404 Uncharacterized conserved protein [Function unknown]; Region: HdeD; cl01277 637381007405 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination...; Region: GlcN6P_deaminase; cd01399 637381007406 active site 637381007407 trimer interface [polypeptide binding]; other site 637381007408 allosteric site; other site 637381007409 active site lid [active] 637381007410 hexamer (dimer of trimers) interface [polypeptide binding]; other site 637381007411 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 637381007412 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637381007413 active site 637381007414 motif I; other site 637381007415 motif II; other site 637381007416 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637381007417 Predicted membrane protein [Function unknown]; Region: COG1511 637381007418 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 637381007419 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 637381007420 ABC-2 type transporter; Region: ABC2_membrane; cl11417 637381007421 Predicted transcriptional regulator [Transcription]; Region: COG1959 637381007422 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381007423 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637381007424 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 637381007425 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 637381007426 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637381007427 catalytic residue [active] 637381007428 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 637381007429 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381007430 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 637381007431 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 637381007432 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381007433 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 637381007434 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 637381007435 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 637381007436 active site 637381007437 dimer interface [polypeptide binding]; other site 637381007438 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 637381007439 dimer interface [polypeptide binding]; other site 637381007440 active site 637381007441 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883 637381007442 nudix motif; other site 637381007443 general stress protein 13; Validated; Region: PRK08059 637381007444 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 637381007445 RNA binding site [nucleotide binding]; other site 637381007446 aspartate aminotransferase; Provisional; Region: PRK08361 637381007447 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637381007448 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637381007449 homodimer interface [polypeptide binding]; other site 637381007450 catalytic residue [active] 637381007451 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 637381007452 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637381007453 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 637381007454 Walker A/P-loop; other site 637381007455 ATP binding site [chemical binding]; other site 637381007456 Q-loop/lid; other site 637381007457 ABC transporter signature motif; other site 637381007458 Walker B; other site 637381007459 D-loop; other site 637381007460 H-loop/switch region; other site 637381007461 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564 637381007462 active site 637381007463 P-loop; other site 637381007464 phosphorylation site [posttranslational modification] 637381007465 aspartate kinase; Reviewed; Region: PRK09034 637381007466 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 637381007467 putative catalytic residues [active] 637381007468 putative nucleotide binding site [chemical binding]; other site 637381007469 putative aspartate binding site [chemical binding]; other site 637381007470 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 637381007471 allosteric regulatory residue; other site 637381007472 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 637381007473 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 637381007474 active site 637381007475 drug efflux system protein MdtG; Provisional; Region: PRK09874 637381007476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637381007477 putative substrate translocation pore; other site 637381007478 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 637381007479 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 637381007480 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 637381007481 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 637381007482 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 637381007483 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 637381007484 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 637381007485 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 637381007486 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 637381007487 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 637381007488 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 637381007489 CoenzymeA binding site [chemical binding]; other site 637381007490 subunit interaction site [polypeptide binding]; other site 637381007491 PHB binding site; other site 637381007492 Divergent PAP2 family; Region: DUF212; cl00855 637381007493 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 637381007494 Cl- selectivity filter; other site 637381007495 Cl- binding residues [ion binding]; other site 637381007496 pore gating glutamate residue; other site 637381007497 dimer interface [polypeptide binding]; other site 637381007498 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 637381007499 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 637381007500 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381007501 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 637381007502 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381007503 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381007504 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 637381007505 NAD(P) binding site [chemical binding]; other site 637381007506 putative active site [active] 637381007507 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 637381007508 Protein of unknown function (DUF1462); Region: DUF1462; cl11552 637381007509 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637381007510 MucBP domain; Region: MucBP; pfam06458 637381007511 MucBP domain; Region: MucBP; pfam06458 637381007512 NifU-like domain; Region: NifU; cl00484 637381007513 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 637381007514 tetramer interfaces [polypeptide binding]; other site 637381007515 binuclear metal-binding site [ion binding]; other site 637381007516 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 637381007517 Domain of unknown function DUF21; Region: DUF21; pfam01595 637381007518 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 637381007519 Transporter associated domain; Region: CorC_HlyC; cl08393 637381007520 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637381007521 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 637381007522 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637381007523 active site 637381007524 motif I; other site 637381007525 motif II; other site 637381007526 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637381007527 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 637381007528 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 637381007529 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 637381007530 active site 637381007531 metal binding site [ion binding]; metal-binding site 637381007532 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 637381007533 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 637381007534 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 637381007535 Protein of unknown function (DUF1634); Region: DUF1634; cl01741 637381007536 Protein of unknown function DUF72; Region: DUF72; cl00777 637381007537 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 637381007538 FeS assembly protein SufB; Region: sufB; TIGR01980 637381007539 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 637381007540 trimerization site [polypeptide binding]; other site 637381007541 active site 637381007542 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 637381007543 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 637381007544 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637381007545 catalytic residue [active] 637381007546 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 637381007547 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 637381007548 FeS assembly ATPase SufC; Region: sufC; TIGR01978 637381007549 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 637381007550 Walker A/P-loop; other site 637381007551 ATP binding site [chemical binding]; other site 637381007552 Q-loop/lid; other site 637381007553 ABC transporter signature motif; other site 637381007554 Walker B; other site 637381007555 D-loop; other site 637381007556 H-loop/switch region; other site 637381007557 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 637381007558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381007559 ABC-ATPase subunit interface; other site 637381007560 putative PBP binding loops; other site 637381007561 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 637381007562 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258 637381007563 Walker A/P-loop; other site 637381007564 ATP binding site [chemical binding]; other site 637381007565 Q-loop/lid; other site 637381007566 ABC transporter signature motif; other site 637381007567 Walker B; other site 637381007568 D-loop; other site 637381007569 H-loop/switch region; other site 637381007570 NIL domain; Region: NIL; cl09633 637381007571 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637381007572 dimer interface [polypeptide binding]; other site 637381007573 phosphorylation site [posttranslational modification] 637381007574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637381007575 ATP binding site [chemical binding]; other site 637381007576 Mg2+ binding site [ion binding]; other site 637381007577 G-X-G motif; other site 637381007578 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637381007579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637381007580 active site 637381007581 phosphorylation site [posttranslational modification] 637381007582 intermolecular recognition site; other site 637381007583 dimerization interface [polypeptide binding]; other site 637381007584 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637381007585 DNA binding site [nucleotide binding] 637381007586 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 637381007587 Cation efflux family; Region: Cation_efflux; cl00316 637381007588 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 637381007589 catalytic residues [active] 637381007590 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 637381007591 lipoyl attachment site [posttranslational modification]; other site 637381007592 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 637381007593 putative ArsC-like catalytic residues; other site 637381007594 putative TRX-like catalytic residues [active] 637381007595 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 637381007596 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 637381007597 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 637381007598 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 637381007599 Walker A/P-loop; other site 637381007600 ATP binding site [chemical binding]; other site 637381007601 Q-loop/lid; other site 637381007602 ABC transporter signature motif; other site 637381007603 Walker B; other site 637381007604 D-loop; other site 637381007605 H-loop/switch region; other site 637381007606 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 637381007607 ABC-ATPase subunit interface; other site 637381007608 dimer interface [polypeptide binding]; other site 637381007609 putative PBP binding regions; other site 637381007610 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 637381007611 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 637381007612 intersubunit interface [polypeptide binding]; other site 637381007613 Predicted esterase [General function prediction only]; Region: COG0627 637381007614 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637381007615 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 637381007616 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 637381007617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637381007618 catalytic residue [active] 637381007619 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 637381007620 CAT RNA binding domain; Region: CAT_RBD; cl03904 637381007621 transcriptional antiterminator BglG; Provisional; Region: PRK09772 637381007622 PRD domain; Region: PRD; pfam00874 637381007623 PRD domain; Region: PRD; pfam00874 637381007624 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 637381007625 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 637381007626 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 637381007627 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 637381007628 Predicted transcriptional regulator [Transcription]; Region: COG2378 637381007629 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381007630 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 637381007631 putative active site [active] 637381007632 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 637381007633 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 637381007634 active site 637381007635 catalytic site [active] 637381007636 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 637381007637 putative metal binding site [ion binding]; other site 637381007638 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 637381007639 putative metal binding site [ion binding]; other site 637381007640 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 637381007641 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 637381007642 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 637381007643 active site 637381007644 catalytic site [active] 637381007645 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 637381007646 putative metal binding site [ion binding]; other site 637381007647 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 637381007648 C-terminal domain; Region: RGG_Cterm; TIGR01716 637381007649 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 637381007650 SmpB-tmRNA interface; other site 637381007651 ribonuclease R; Region: RNase_R; TIGR02063 637381007652 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 637381007653 RNB domain; Region: RNB; pfam00773 637381007654 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471 637381007655 RNA binding site [nucleotide binding]; other site 637381007656 Esterase/lipase [General function prediction only]; Region: COG1647 637381007657 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637381007658 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637381007659 Esterase/lipase [General function prediction only]; Region: COG1647 637381007660 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637381007661 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637381007662 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637381007663 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 637381007664 enolase; Provisional; Region: eno; PRK00077 637381007665 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 637381007666 dimer interface [polypeptide binding]; other site 637381007667 metal binding site [ion binding]; metal-binding site 637381007668 substrate binding pocket [chemical binding]; other site 637381007669 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 637381007670 Sulfatase; Region: Sulfatase; cl10460 637381007671 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 637381007672 substrate binding site [chemical binding]; other site 637381007673 dimer interface [polypeptide binding]; other site 637381007674 catalytic triad [active] 637381007675 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 637381007676 substrate binding site [chemical binding]; other site 637381007677 hinge regions; other site 637381007678 ADP binding site [chemical binding]; other site 637381007679 catalytic site [active] 637381007680 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 637381007681 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 637381007682 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 637381007683 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 637381007684 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 637381007685 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 637381007686 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 637381007687 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 637381007688 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 637381007689 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics...; Region: rDP_like; cd01301 637381007690 active site 637381007691 dimer interface [polypeptide binding]; other site 637381007692 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 637381007693 Protein export membrane protein; Region: SecD_SecF; cl14618 637381007694 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637381007695 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637381007696 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 637381007697 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 637381007698 Chitin binding domain; Region: Chitin_bind_3; cl03871 637381007699 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 637381007700 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 637381007701 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036 637381007702 chitin/cellulose binding site [chemical binding]; other site 637381007703 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036 637381007704 chitin/cellulose binding site [chemical binding]; other site 637381007705 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 637381007706 oligomer interface [polypeptide binding]; other site 637381007707 active site residues [active] 637381007708 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637381007709 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 637381007710 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309 637381007711 Substrate binding site [chemical binding]; other site 637381007712 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637381007713 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 637381007714 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 637381007715 active site 637381007716 FMN binding site [chemical binding]; other site 637381007717 substrate binding site [chemical binding]; other site 637381007718 homotetramer interface [polypeptide binding]; other site 637381007719 catalytic residue [active] 637381007720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 637381007721 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 637381007722 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 637381007723 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 637381007724 phosphate binding site [ion binding]; other site 637381007725 putative substrate binding pocket [chemical binding]; other site 637381007726 dimer interface [polypeptide binding]; other site 637381007727 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381007728 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 637381007729 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799 637381007730 active site 637381007731 substrate binding site [chemical binding]; other site 637381007732 metal binding site [ion binding]; metal-binding site 637381007733 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 637381007734 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 637381007735 active site 637381007736 catalytic residues [active] 637381007737 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 637381007738 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 637381007739 NAD binding site [chemical binding]; other site 637381007740 homodimer interface [polypeptide binding]; other site 637381007741 active site 637381007742 substrate binding site [chemical binding]; other site 637381007743 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 637381007744 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381007745 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381007746 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 637381007747 binding surface 637381007748 TPR motif; other site 637381007749 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 637381007750 binding surface 637381007751 TPR motif; other site 637381007752 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 637381007753 putative trimer interface [polypeptide binding]; other site 637381007754 putative CoA binding site [chemical binding]; other site 637381007755 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 637381007756 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637381007757 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637381007758 motif II; other site 637381007759 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 637381007760 HPr kinase/phosphorylase; Provisional; Region: PRK05428 637381007761 DRTGG domain; Region: DRTGG; cl12147 637381007762 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918 637381007763 Hpr binding site; other site 637381007764 active site 637381007765 homohexamer subunit interaction site [polypeptide binding]; other site 637381007766 Membrane protein of unknown function; Region: DUF360; cl00850 637381007767 PspC domain; Region: PspC; cl00864 637381007768 PspC domain; Region: PspC; cl00864 637381007769 Uncharacterized conserved protein [Function unknown]; Region: COG3595 637381007770 Uncharacterized conserved protein [Function unknown]; Region: COG3595 637381007771 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 637381007772 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 637381007773 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 637381007774 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 637381007775 excinuclease ABC subunit B; Provisional; Region: PRK05298 637381007776 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637381007777 ATP binding site [chemical binding]; other site 637381007778 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637381007779 nucleotide binding region [chemical binding]; other site 637381007780 ATP-binding site [chemical binding]; other site 637381007781 Ultra-violet resistance protein B; Region: UvrB; pfam12344 637381007782 UvrB/uvrC motif; Region: UVR; pfam02151 637381007783 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 637381007784 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 637381007785 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637381007786 dimerization interface [polypeptide binding]; other site 637381007787 putative DNA binding site [nucleotide binding]; other site 637381007788 putative Zn2+ binding site [ion binding]; other site 637381007789 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 637381007790 PhoU domain; Region: PhoU; pfam01895 637381007791 PhoU domain; Region: PhoU; pfam01895 637381007792 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 637381007793 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 637381007794 Walker A/P-loop; other site 637381007795 ATP binding site [chemical binding]; other site 637381007796 Q-loop/lid; other site 637381007797 ABC transporter signature motif; other site 637381007798 Walker B; other site 637381007799 D-loop; other site 637381007800 H-loop/switch region; other site 637381007801 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 637381007802 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 637381007803 Walker A/P-loop; other site 637381007804 ATP binding site [chemical binding]; other site 637381007805 Q-loop/lid; other site 637381007806 ABC transporter signature motif; other site 637381007807 Walker B; other site 637381007808 D-loop; other site 637381007809 H-loop/switch region; other site 637381007810 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 637381007811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381007812 dimer interface [polypeptide binding]; other site 637381007813 conserved gate region; other site 637381007814 putative PBP binding loops; other site 637381007815 ABC-ATPase subunit interface; other site 637381007816 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 637381007817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381007818 dimer interface [polypeptide binding]; other site 637381007819 conserved gate region; other site 637381007820 putative PBP binding loops; other site 637381007821 ABC-ATPase subunit interface; other site 637381007822 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637381007823 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 637381007824 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 637381007825 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 637381007826 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637381007827 dimer interface [polypeptide binding]; other site 637381007828 phosphorylation site [posttranslational modification] 637381007829 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637381007830 ATP binding site [chemical binding]; other site 637381007831 Mg2+ binding site [ion binding]; other site 637381007832 G-X-G motif; other site 637381007833 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637381007834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637381007835 active site 637381007836 phosphorylation site [posttranslational modification] 637381007837 intermolecular recognition site; other site 637381007838 dimerization interface [polypeptide binding]; other site 637381007839 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637381007840 DNA binding site [nucleotide binding] 637381007841 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 637381007842 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 637381007843 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 637381007844 putative active site [active] 637381007845 catalytic site [active] 637381007846 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 637381007847 putative active site [active] 637381007848 catalytic site [active] 637381007849 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 637381007850 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 637381007851 Peptidase family M23; Region: Peptidase_M23; pfam01551 637381007852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 637381007853 NlpC/P60 family; Region: NLPC_P60; cl11438 637381007854 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 637381007855 FtsX-like permease family; Region: FtsX; pfam02687 637381007856 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 637381007857 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381007858 Walker A/P-loop; other site 637381007859 ATP binding site [chemical binding]; other site 637381007860 Q-loop/lid; other site 637381007861 ABC transporter signature motif; other site 637381007862 Walker B; other site 637381007863 D-loop; other site 637381007864 H-loop/switch region; other site 637381007865 Uncharacterized conserved protein [Function unknown]; Region: COG1284 637381007866 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 637381007867 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 637381007868 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 637381007869 peptide chain release factor 2; Validated; Region: prfB; PRK00578 637381007870 RF-1 domain; Region: RF-1; cl02875 637381007871 RF-1 domain; Region: RF-1; cl02875 637381007872 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 637381007873 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381007874 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 637381007875 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381007876 SEC-C motif; Region: SEC-C; cl12132 637381007877 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 637381007878 30S subunit binding site; other site 637381007879 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 637381007880 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 637381007881 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 637381007882 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637381007883 ATP binding site [chemical binding]; other site 637381007884 putative Mg++ binding site [ion binding]; other site 637381007885 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381007886 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 637381007887 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 637381007888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637381007889 active site 637381007890 phosphorylation site [posttranslational modification] 637381007891 intermolecular recognition site; other site 637381007892 dimerization interface [polypeptide binding]; other site 637381007893 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 637381007894 DNA binding residues [nucleotide binding] 637381007895 dimerization interface [polypeptide binding]; other site 637381007896 Uncharacterized conserved protein [Function unknown]; Region: COG1739 637381007897 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 637381007898 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 637381007899 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637381007900 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637381007901 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 637381007902 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 637381007903 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 637381007904 Mg++ binding site [ion binding]; other site 637381007905 putative catalytic motif [active] 637381007906 substrate binding site [chemical binding]; other site 637381007907 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 637381007908 o-succinylbenzoic acid (OSB) synthetase; Region: menC_lowGC/arch; TIGR01928 637381007909 active site 637381007910 octamer interface [polypeptide binding]; other site 637381007911 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 637381007912 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 637381007913 putative peptidoglycan binding site; other site 637381007914 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 637381007915 putative peptidoglycan binding site; other site 637381007916 3D domain; Region: 3D; cl01439 637381007917 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 637381007918 dimer interface [polypeptide binding]; other site 637381007919 ssDNA binding site [nucleotide binding]; other site 637381007920 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637381007921 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 637381007922 rod shape-determining protein Mbl; Provisional; Region: PRK13928 637381007923 Cell division protein FtsA; Region: FtsA; cl11496 637381007924 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 637381007925 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 637381007926 hinge; other site 637381007927 active site 637381007928 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 637381007929 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 637381007930 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 637381007931 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 637381007932 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 637381007933 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 637381007934 alpha subunit interaction interface [polypeptide binding]; other site 637381007935 Walker A motif; other site 637381007936 ATP binding site [chemical binding]; other site 637381007937 Walker B motif; other site 637381007938 inhibitor binding site; inhibition site 637381007939 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 637381007940 ATP synthase; Region: ATP-synt; cl00365 637381007941 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 637381007942 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 637381007943 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 637381007944 beta subunit interaction interface [polypeptide binding]; other site 637381007945 Walker A motif; other site 637381007946 ATP binding site [chemical binding]; other site 637381007947 Walker B motif; other site 637381007948 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 637381007949 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 637381007950 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 637381007951 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 637381007952 ATP synthase subunit C; Region: ATP-synt_C; cl00466 637381007953 ATP synthase A chain; Region: ATP-synt_A; cl00413 637381007954 ATP synthase I chain; Region: ATP_synt_I; cl09170 637381007955 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 637381007956 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 637381007957 active site 637381007958 homodimer interface [polypeptide binding]; other site 637381007959 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 637381007960 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 637381007961 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 637381007962 dimer interface [polypeptide binding]; other site 637381007963 glycine-pyridoxal phosphate binding site [chemical binding]; other site 637381007964 active site 637381007965 folate binding site [chemical binding]; other site 637381007966 Low molecular weight phosphatase family; Region: LMWPc; cd00115 637381007967 Active site [active] 637381007968 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 637381007969 SUA5 domain; Region: SUA5; pfam03481 637381007970 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 637381007971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637381007972 S-adenosylmethionine binding site [chemical binding]; other site 637381007973 peptide chain release factor 1; Validated; Region: prfA; PRK00591 637381007974 RF-1 domain; Region: RF-1; cl02875 637381007975 RF-1 domain; Region: RF-1; cl02875 637381007976 Thymidine kinase; Region: TK; cl00631 637381007977 homoserine kinase; Provisional; Region: PRK01212 637381007978 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 637381007979 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 637381007980 threonine synthase; Reviewed; Region: PRK06721 637381007981 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563 637381007982 homodimer interface [polypeptide binding]; other site 637381007983 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637381007984 catalytic residue [active] 637381007985 homoserine dehydrogenase; Provisional; Region: PRK06349 637381007986 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381007987 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 637381007988 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 637381007989 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 637381007990 GtrA-like protein; Region: GtrA; cl00971 637381007991 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 637381007992 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 637381007993 Ligand binding site [chemical binding]; other site 637381007994 Putative Catalytic site [active] 637381007995 DXD motif; other site 637381007996 transcription termination factor Rho; Provisional; Region: rho; PRK09376 637381007997 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 637381007998 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 637381007999 RNA binding site [nucleotide binding]; other site 637381008000 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 637381008001 multimer interface [polypeptide binding]; other site 637381008002 Walker A motif; other site 637381008003 ATP binding site [chemical binding]; other site 637381008004 Walker B motif; other site 637381008005 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 637381008006 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 637381008007 hinge; other site 637381008008 active site 637381008009 Predicted integral membrane protein [Function unknown]; Region: COG0392 637381008010 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 637381008011 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 637381008012 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 637381008013 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-...; Region: GT1_UGDG_like; cd03817 637381008014 putative ADP-binding pocket [chemical binding]; other site 637381008015 hypothetical protein; Provisional; Region: PRK08185 637381008016 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 637381008017 intersubunit interface [polypeptide binding]; other site 637381008018 active site 637381008019 zinc binding site [ion binding]; other site 637381008020 Na+ binding site [ion binding]; other site 637381008021 putative lipid kinase; Reviewed; Region: PRK13055 637381008022 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 637381008023 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 637381008024 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 637381008025 amidase catalytic site [active] 637381008026 Zn binding residues [ion binding]; other site 637381008027 substrate binding site [chemical binding]; other site 637381008028 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 637381008029 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 637381008030 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 637381008031 CTP synthetase; Validated; Region: pyrG; PRK05380 637381008032 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 637381008033 Catalytic site [active] 637381008034 Active site [active] 637381008035 UTP binding site [chemical binding]; other site 637381008036 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 637381008037 active site 637381008038 putative oxyanion hole; other site 637381008039 catalytic triad [active] 637381008040 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 637381008041 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 637381008042 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 637381008043 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 637381008044 active site 637381008045 HIGH motif; other site 637381008046 KMSK motif region; other site 637381008047 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 637381008048 tRNA binding surface [nucleotide binding]; other site 637381008049 anticodon binding site; other site 637381008050 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 637381008051 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 637381008052 active site 637381008053 putative substrate binding region [chemical binding]; other site 637381008054 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 637381008055 active site 1 [active] 637381008056 dimer interface [polypeptide binding]; other site 637381008057 hexamer interface [polypeptide binding]; other site 637381008058 active site 2 [active] 637381008059 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 637381008060 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637381008061 Zn2+ binding site [ion binding]; other site 637381008062 Mg2+ binding site [ion binding]; other site 637381008063 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 637381008064 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 637381008065 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 637381008066 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 637381008067 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 637381008068 peptide binding site [polypeptide binding]; other site 637381008069 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 637381008070 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 637381008071 catalytic triad [active] 637381008072 metal binding site [ion binding]; metal-binding site 637381008073 conserved cis-peptide bond; other site 637381008074 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 637381008075 folate binding site [chemical binding]; other site 637381008076 NADP+ binding site [chemical binding]; other site 637381008077 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 637381008078 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 637381008079 putative NAD(P) binding site [chemical binding]; other site 637381008080 dimer interface [polypeptide binding]; other site 637381008081 Cation efflux family; Region: Cation_efflux; cl00316 637381008082 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 637381008083 Collagen binding domain; Region: Collagen_bind; pfam05737 637381008084 Collagen binding domain; Region: Collagen_bind; pfam05737 637381008085 Collagen binding domain; Region: Collagen_bind; pfam05737 637381008086 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637381008087 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637381008088 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637381008089 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637381008090 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637381008091 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637381008092 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 637381008093 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637381008094 active site 637381008095 motif I; other site 637381008096 motif II; other site 637381008097 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637381008098 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 637381008099 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 637381008100 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637381008101 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 637381008102 Walker A/P-loop; other site 637381008103 ATP binding site [chemical binding]; other site 637381008104 Q-loop/lid; other site 637381008105 ABC transporter signature motif; other site 637381008106 Walker B; other site 637381008107 D-loop; other site 637381008108 H-loop/switch region; other site 637381008109 FtsX-like permease family; Region: FtsX; pfam02687 637381008110 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 637381008111 dimerization interface [polypeptide binding]; other site 637381008112 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637381008113 dimer interface [polypeptide binding]; other site 637381008114 phosphorylation site [posttranslational modification] 637381008115 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637381008116 ATP binding site [chemical binding]; other site 637381008117 Mg2+ binding site [ion binding]; other site 637381008118 G-X-G motif; other site 637381008119 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637381008120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637381008121 active site 637381008122 phosphorylation site [posttranslational modification] 637381008123 intermolecular recognition site; other site 637381008124 dimerization interface [polypeptide binding]; other site 637381008125 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637381008126 DNA binding site [nucleotide binding] 637381008127 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 637381008128 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 637381008129 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 637381008130 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 637381008131 catalytic loop [active] 637381008132 iron binding site [ion binding]; other site 637381008133 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 637381008134 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H)...; Region: MopB_Formate-Dh-H; cd02753 637381008135 [4Fe-4S] binding site [ion binding]; other site 637381008136 molybdopterin cofactor binding site; other site 637381008137 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 637381008138 molybdopterin cofactor binding site; other site 637381008139 Uncharacterized conserved protein [Function unknown]; Region: COG1912 637381008140 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 637381008141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637381008142 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637381008143 putative substrate translocation pore; other site 637381008144 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637381008145 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637381008146 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...; Region: ZnMc; cl00064 637381008147 active site 637381008148 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 637381008149 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 637381008150 dimer interface [polypeptide binding]; other site 637381008151 putative anticodon binding site; other site 637381008152 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 637381008153 motif 1; other site 637381008154 active site 637381008155 motif 2; other site 637381008156 motif 3; other site 637381008157 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 637381008158 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 637381008159 FMN binding site [chemical binding]; other site 637381008160 active site 637381008161 catalytic residues [active] 637381008162 substrate binding site [chemical binding]; other site 637381008163 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 637381008164 catalytic center binding site [active] 637381008165 ATP binding site [chemical binding]; other site 637381008166 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines...; Region: DHNA_DHNTPE; cd00534 637381008167 homooctamer interface [polypeptide binding]; other site 637381008168 active site 637381008169 dihydropteroate synthase; Region: DHPS; TIGR01496 637381008170 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 637381008171 substrate binding pocket [chemical binding]; other site 637381008172 dimer interface [polypeptide binding]; other site 637381008173 inhibitor binding site; inhibition site 637381008174 cysteine synthases; Region: cysKM; TIGR01136 637381008175 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 637381008176 dimer interface [polypeptide binding]; other site 637381008177 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637381008178 catalytic residue [active] 637381008179 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 637381008180 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 637381008181 dimerization interface [polypeptide binding]; other site 637381008182 domain crossover interface; other site 637381008183 redox-dependent activation switch; other site 637381008184 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 637381008185 FtsH Extracellular; Region: FtsH_ext; pfam06480 637381008186 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 637381008187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637381008188 Walker A motif; other site 637381008189 ATP binding site [chemical binding]; other site 637381008190 Walker B motif; other site 637381008191 arginine finger; other site 637381008192 Peptidase family M41; Region: Peptidase_M41; pfam01434 637381008193 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 637381008194 Ligand Binding Site [chemical binding]; other site 637381008195 B3/4 domain; Region: B3_4; cl11458 637381008196 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 637381008197 hypothetical protein; Provisional; Region: PRK08582 637381008198 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 637381008199 RNA binding site [nucleotide binding]; other site 637381008200 Septum formation initiator; Region: DivIC; cl11433 637381008201 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 637381008202 stage V sporulation protein B; Region: spore_V_B; TIGR02900 637381008203 MatE; Region: MatE; cl10513 637381008204 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 637381008205 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 637381008206 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637381008207 ATP binding site [chemical binding]; other site 637381008208 putative Mg++ binding site [ion binding]; other site 637381008209 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637381008210 nucleotide binding region [chemical binding]; other site 637381008211 ATP-binding site [chemical binding]; other site 637381008212 TRCF domain; Region: TRCF; cl04088 637381008213 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 637381008214 putative active site [active] 637381008215 catalytic residue [active] 637381008216 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637381008217 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 637381008218 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 637381008219 5S rRNA interface [nucleotide binding]; other site 637381008220 CTC domain interface [polypeptide binding]; other site 637381008221 L16 interface [polypeptide binding]; other site 637381008222 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 637381008223 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 637381008224 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637381008225 NAD binding site [chemical binding]; other site 637381008226 dimer interface [polypeptide binding]; other site 637381008227 substrate binding site [chemical binding]; other site 637381008228 A new structural DNA glycosylase; Region: AlkD_like; cd06561 637381008229 Active site [active] 637381008230 Domain of unknown function (DUF74); Region: DUF74; cl00426 637381008231 Protein of unknown function (DUF1307); Region: DUF1307; cl01981 637381008232 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; cl03005 637381008233 ActA Protein; Region: ActA; pfam05058 637381008234 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 637381008235 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 637381008236 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 637381008237 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 637381008238 active site 637381008239 Zn binding site [ion binding]; other site 637381008240 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 637381008241 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 637381008242 active site 637381008243 catalytic site [active] 637381008244 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 637381008245 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 637381008246 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 637381008247 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 637381008248 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 637381008249 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 637381008250 Substrate binding site [chemical binding]; other site 637381008251 Mg++ binding site [ion binding]; other site 637381008252 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 637381008253 active site 637381008254 substrate binding site [chemical binding]; other site 637381008255 CoA binding site [chemical binding]; other site 637381008256 SpoVG; Region: SpoVG; cl00915 637381008257 SpoVG; Region: SpoVG; cl00915 637381008258 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 637381008259 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 637381008260 FtsX-like permease family; Region: FtsX; pfam02687 637381008261 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637381008262 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 637381008263 Walker A/P-loop; other site 637381008264 ATP binding site [chemical binding]; other site 637381008265 Q-loop/lid; other site 637381008266 ABC transporter signature motif; other site 637381008267 Walker B; other site 637381008268 D-loop; other site 637381008269 H-loop/switch region; other site 637381008270 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 637381008271 pur operon repressor; Provisional; Region: PRK09213 637381008272 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 637381008273 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 637381008274 YdjC-like protein; Region: YdjC; cl01344 637381008275 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 637381008276 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 637381008277 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 637381008278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637381008279 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 637381008280 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in...; Region: TOPRIM_RNase_M5_like; cd01027 637381008281 putative active site [active] 637381008282 putative metal binding site [ion binding]; other site 637381008283 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 637381008284 Domain of unknown function (DUF348); Region: DUF348; pfam03990 637381008285 Domain of unknown function (DUF348); Region: DUF348; pfam03990 637381008286 G5 domain; Region: G5; pfam07501 637381008287 3D domain; Region: 3D; cl01439 637381008288 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 637381008289 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 637381008290 active site 637381008291 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 637381008292 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 637381008293 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 637381008294 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 637381008295 trimer interface [polypeptide binding]; other site 637381008296 active site 637381008297 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 637381008298 catalytic site [active] 637381008299 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 637381008300 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 637381008301 active site 637381008302 catalytic site [active] 637381008303 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 637381008304 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637381008305 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 637381008306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381008307 dimer interface [polypeptide binding]; other site 637381008308 conserved gate region; other site 637381008309 putative PBP binding loops; other site 637381008310 ABC-ATPase subunit interface; other site 637381008311 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 637381008312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381008313 dimer interface [polypeptide binding]; other site 637381008314 conserved gate region; other site 637381008315 putative PBP binding loops; other site 637381008316 ABC-ATPase subunit interface; other site 637381008317 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637381008318 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 637381008319 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 637381008320 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 637381008321 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 637381008322 active site 637381008323 HIGH motif; other site 637381008324 KMSKS motif; other site 637381008325 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 637381008326 tRNA binding surface [nucleotide binding]; other site 637381008327 anticodon binding site; other site 637381008328 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 637381008329 dimer interface [polypeptide binding]; other site 637381008330 putative tRNA-binding site [nucleotide binding]; other site 637381008331 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 637381008332 MucBP domain; Region: MucBP; pfam06458 637381008333 Integrase core domain; Region: rve; cl01316 637381008334 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 637381008335 LRR adjacent; Region: LRR_adjacent; pfam08191 637381008336 MucBP domain; Region: MucBP; pfam06458 637381008337 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 637381008338 Uncharacterized conserved protein [Function unknown]; Region: COG5361 637381008339 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 637381008340 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 637381008341 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 637381008342 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 637381008343 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 637381008344 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 637381008345 Predicted methyltransferases [General function prediction only]; Region: COG0313 637381008346 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 637381008347 GIY-YIG motif/motif A; other site 637381008348 putative active site [active] 637381008349 putative metal binding site [ion binding]; other site 637381008350 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 637381008351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637381008352 S-adenosylmethionine binding site [chemical binding]; other site 637381008353 Protein of unknown function (DUF972); Region: DUF972; cl01853 637381008354 PSP1 C-terminal conserved region; Region: PSP1; cl00770 637381008355 DNA polymerase III subunit delta'; Validated; Region: PRK08058 637381008356 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381008357 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 637381008358 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 637381008359 Collagen binding domain; Region: Collagen_bind; pfam05737 637381008360 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637381008361 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637381008362 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 637381008363 Collagen binding domain; Region: Collagen_bind; pfam05737 637381008364 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637381008365 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637381008366 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637381008367 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637381008368 sugar phosphate phosphatase; Provisional; Region: PRK10513 637381008369 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637381008370 active site 637381008371 motif I; other site 637381008372 motif II; other site 637381008373 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637381008374 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 637381008375 DEAD_2; Region: DEAD_2; cl14887 637381008376 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381008377 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 637381008378 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 637381008379 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 637381008380 ABC-ATPase subunit interface; other site 637381008381 dimer interface [polypeptide binding]; other site 637381008382 putative PBP binding regions; other site 637381008383 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 637381008384 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 637381008385 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 637381008386 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 637381008387 metal binding site [ion binding]; metal-binding site 637381008388 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 637381008389 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 637381008390 peptide binding site [polypeptide binding]; other site 637381008391 Bacillus transposase protein; Region: Transposase_30; pfam04740 637381008392 Protein of unknown function (DUF3130; Region: DUF3130; pfam11328 637381008393 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 637381008394 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 637381008395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381008396 dimer interface [polypeptide binding]; other site 637381008397 conserved gate region; other site 637381008398 putative PBP binding loops; other site 637381008399 ABC-ATPase subunit interface; other site 637381008400 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 637381008401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637381008402 dimer interface [polypeptide binding]; other site 637381008403 conserved gate region; other site 637381008404 putative PBP binding loops; other site 637381008405 ABC-ATPase subunit interface; other site 637381008406 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 637381008407 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 637381008408 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637381008409 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 637381008410 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 637381008411 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 637381008412 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH_2; cd04602 637381008413 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 637381008414 active site 637381008415 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 637381008416 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 637381008417 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 637381008418 putative active site [active] 637381008419 putative metal binding site [ion binding]; other site 637381008420 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 637381008421 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 637381008422 active site 637381008423 metal binding site [ion binding]; metal-binding site 637381008424 Holin family; Region: Phage_holin_4; cl01989 637381008425 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 637381008426 Phage tail protein; Region: Sipho_tail; cl11462 637381008427 Phage-related protein [Function unknown]; Region: COG5412 637381008428 Phage major tail protein 2; Region: Phage_tail_2; cl11463 637381008429 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 637381008430 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637381008431 non-specific DNA binding site [nucleotide binding]; other site 637381008432 salt bridge; other site 637381008433 sequence-specific DNA binding site [nucleotide binding]; other site 637381008434 Domain of unknown function (DUF955); Region: DUF955; cl01076 637381008435 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 637381008436 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 637381008437 ligand binding site [chemical binding]; other site 637381008438 flexible hinge region; other site 637381008439 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 637381008440 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637381008441 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 637381008442 substrate binding pocket [chemical binding]; other site 637381008443 Cupin domain; Region: Cupin_2; cl09118 637381008444 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637381008445 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637381008446 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637381008447 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637381008448 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 637381008449 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 637381008450 Walker A/P-loop; other site 637381008451 ATP binding site [chemical binding]; other site 637381008452 Q-loop/lid; other site 637381008453 ABC transporter signature motif; other site 637381008454 Walker B; other site 637381008455 D-loop; other site 637381008456 H-loop/switch region; other site 637381008457 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637381008458 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 637381008459 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 637381008460 Walker A/P-loop; other site 637381008461 ATP binding site [chemical binding]; other site 637381008462 Q-loop/lid; other site 637381008463 ABC transporter signature motif; other site 637381008464 Walker B; other site 637381008465 D-loop; other site 637381008466 H-loop/switch region; other site 637381008467 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 637381008468 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 637381008469 Acetokinase family; Region: Acetate_kinase; cl01029 637381008470 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 637381008471 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is...; Region: GH18_chitinase; cd06548 637381008472 active site 637381008473 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 637381008474 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 637381008475 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 637381008476 dimer interface [polypeptide binding]; other site 637381008477 FMN binding site [chemical binding]; other site 637381008478 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 637381008479 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637381008480 dimerization interface [polypeptide binding]; other site 637381008481 putative DNA binding site [nucleotide binding]; other site 637381008482 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; cl02047 637381008483 Domain of unknown function (DUF956); Region: DUF956; cl01917 637381008484 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 637381008485 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 637381008486 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 637381008487 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006 637381008488 active pocket/dimerization site; other site 637381008489 active site 637381008490 phosphorylation site [posttranslational modification] 637381008491 Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four...; Region: PTS_IIB_man; cd00001 637381008492 active site 637381008493 phosphorylation site [posttranslational modification] 637381008494 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 637381008495 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 637381008496 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 637381008497 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 637381008498 alpha subunit interaction interface [polypeptide binding]; other site 637381008499 Walker A motif; other site 637381008500 ATP binding site [chemical binding]; other site 637381008501 Walker B motif; other site 637381008502 inhibitor binding site; inhibition site 637381008503 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 637381008504 ATP synthase; Region: ATP-synt; cl00365 637381008505 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 637381008506 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381008507 Walker A motif; other site 637381008508 ATP binding site [chemical binding]; other site 637381008509 Walker B motif; other site 637381008510 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 637381008511 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 637381008512 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 637381008513 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 637381008514 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 637381008515 active site 637381008516 catalytic tetrad [active] 637381008517 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 637381008518 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 637381008519 DNA binding residues [nucleotide binding] 637381008520 putative dimer interface [polypeptide binding]; other site 637381008521 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 637381008522 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381008523 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 637381008524 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 637381008525 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 637381008526 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 637381008527 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 637381008528 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 637381008529 DNA binding site [nucleotide binding] 637381008530 active site 637381008531 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 637381008532 tetramer interface [polypeptide binding]; other site 637381008533 active site 637381008534 Mg2+/Mn2+ binding site [ion binding]; other site 637381008535 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 637381008536 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 637381008537 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381008538 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381008539 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381008540 Predicted membrane protein essB; Region: essB; cl01868 637381008541 YukD; Region: YukD; cl11566 637381008542 Firmicute eSAT-6 protein secretion system EssA; Region: EssA; cl11266 637381008543 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 637381008544 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 637381008545 Proteins of 100 residues with WXG; Region: WXG100; cl02005 637381008546 adenylosuccinate synthetase; Provisional; Region: PRK01117 637381008547 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 637381008548 GDP-binding site [chemical binding]; other site 637381008549 ACT binding site; other site 637381008550 IMP binding site; other site 637381008551 replicative DNA helicase; Provisional; Region: PRK05748 637381008552 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 637381008553 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 637381008554 Walker A motif; other site 637381008555 ATP binding site [chemical binding]; other site 637381008556 Walker B motif; other site 637381008557 DNA binding loops [nucleotide binding] 637381008558 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 637381008559 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 637381008560 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 637381008561 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 637381008562 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 637381008563 DHH family; Region: DHH; pfam01368 637381008564 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 637381008565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637381008566 active site 637381008567 phosphorylation site [posttranslational modification] 637381008568 intermolecular recognition site; other site 637381008569 LytTr DNA-binding domain; Region: LytTR; cl04498 637381008570 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 637381008571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 637381008572 Accessory gene regulator B; Region: AgrB; cl01873 637381008573 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 637381008574 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 637381008575 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 637381008576 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 637381008577 dimer interface [polypeptide binding]; other site 637381008578 ssDNA binding site [nucleotide binding]; other site 637381008579 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637381008580 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 637381008581 Amidinotransferase; Region: Amidinotransf; cl12043 637381008582 Arginine deiminase [Amino acid transport and metabolism]; Region: ArcA; COG2235 637381008583 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 637381008584 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 637381008585 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 637381008586 putative active site [active] 637381008587 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 637381008588 agmatine deiminase; Region: agmatine_aguA; TIGR03380 637381008589 carbamate kinase; Reviewed; Region: PRK12686 637381008590 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 637381008591 putative substrate binding site [chemical binding]; other site 637381008592 nucleotide binding site [chemical binding]; other site 637381008593 nucleotide binding site [chemical binding]; other site 637381008594 homodimer interface [polypeptide binding]; other site 637381008595 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 637381008596 agmatine deiminase; Region: agmatine_aguA; TIGR03380 637381008597 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637381008598 putrescine carbamoyltransferase; Provisional; Region: PRK02255 637381008599 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 637381008600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637381008601 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 637381008602 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 637381008603 dimer interface [polypeptide binding]; other site 637381008604 active site 637381008605 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 637381008606 dimer interface [polypeptide binding]; other site 637381008607 active site 637381008608 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637381008609 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 637381008610 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 637381008611 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 637381008612 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 637381008613 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 637381008614 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637381008615 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637381008616 DNA binding site [nucleotide binding] 637381008617 domain linker motif; other site 637381008618 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 637381008619 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 637381008620 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637381008621 active site 637381008622 motif I; other site 637381008623 motif II; other site 637381008624 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637381008625 Protein of unknown function (DUF2712); Region: DUF2712; pfam10916 637381008626 Protein of unknown function (DUF2705); Region: DUF2705; pfam10920 637381008627 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637381008628 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381008629 Walker A/P-loop; other site 637381008630 ATP binding site [chemical binding]; other site 637381008631 Q-loop/lid; other site 637381008632 ABC transporter signature motif; other site 637381008633 Walker B; other site 637381008634 D-loop; other site 637381008635 H-loop/switch region; other site 637381008636 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 637381008637 putative dimer interface [polypeptide binding]; other site 637381008638 catalytic triad [active] 637381008639 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 637381008640 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 637381008641 active site turn [active] 637381008642 phosphorylation site [posttranslational modification] 637381008643 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637381008644 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cd00210 637381008645 HPr interaction site; other site 637381008646 glycerol kinase (GK) interaction site [polypeptide binding]; other site 637381008647 active site 637381008648 phosphorylation site [posttranslational modification] 637381008649 CutC family; Region: CutC; cl01218 637381008650 hypothetical protein; Provisional; Region: PRK02947 637381008651 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 637381008652 putative active site [active] 637381008653 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 637381008654 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 637381008655 Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four...; Region: PTS_IIB_man; cd00001 637381008656 active site 637381008657 phosphorylation site [posttranslational modification] 637381008658 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006 637381008659 active pocket/dimerization site; other site 637381008660 active site 637381008661 phosphorylation site [posttranslational modification] 637381008662 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 637381008663 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637381008664 DNA-binding site [nucleotide binding]; DNA binding site 637381008665 UTRA domain; Region: UTRA; cl01230 637381008666 Bacterial SH3 domain; Region: SH3_3; cl02551 637381008667 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 637381008668 putative active site [active] 637381008669 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 637381008670 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 637381008671 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 637381008672 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 637381008673 putative active site [active] 637381008674 putative metal binding site [ion binding]; other site 637381008675 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 637381008676 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 637381008677 Subunit I/III interface [polypeptide binding]; other site 637381008678 Subunit III/IV interface [polypeptide binding]; other site 637381008679 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 637381008680 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 637381008681 D-pathway; other site 637381008682 Putative ubiquinol binding site [chemical binding]; other site 637381008683 Low-spin heme (heme b) binding site [chemical binding]; other site 637381008684 Putative water exit pathway; other site 637381008685 Binuclear center (heme o3/CuB) [ion binding]; other site 637381008686 K-pathway; other site 637381008687 Putative proton exit pathway; other site 637381008688 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 637381008689 Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 637381008690 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 637381008691 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 637381008692 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 637381008693 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 637381008694 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 637381008695 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 637381008696 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 637381008697 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637381008698 cardiolipin synthetase; Reviewed; Region: PRK12452 637381008699 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 637381008700 putative active site [active] 637381008701 catalytic site [active] 637381008702 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 637381008703 putative active site [active] 637381008704 catalytic site [active] 637381008705 DNA gyrase subunit A; Validated; Region: PRK05560 637381008706 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 637381008707 CAP-like domain; other site 637381008708 Active site [active] 637381008709 primary dimer interface [polypeptide binding]; other site 637381008710 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637381008711 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637381008712 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637381008713 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637381008714 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637381008715 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 637381008716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637381008717 Mg2+ binding site [ion binding]; other site 637381008718 G-X-G motif; other site 637381008719 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 637381008720 anchoring element; other site 637381008721 dimer interface [polypeptide binding]; other site 637381008722 ATP binding site [chemical binding]; other site 637381008723 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 637381008724 active site 637381008725 putative metal-binding site [ion binding]; other site 637381008726 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 637381008727 recombination protein F; Reviewed; Region: recF; PRK00064 637381008728 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 637381008729 Walker A/P-loop; other site 637381008730 ATP binding site [chemical binding]; other site 637381008731 Q-loop/lid; other site 637381008732 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637381008733 ABC transporter signature motif; other site 637381008734 Walker B; other site 637381008735 D-loop; other site 637381008736 H-loop/switch region; other site 637381008737 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 637381008738 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 637381008739 MatE; Region: MatE; cl10513 637381008740 MatE; Region: MatE; cl10513 637381008741 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 637381008742 DNA polymerase III beta subunit; Region: POL3Bc; smart00480 637381008743 putative DNA binding surface [nucleotide binding]; other site 637381008744 dimer interface [polypeptide binding]; other site 637381008745 beta-clamp/clamp loader binding surface; other site 637381008746 beta-clamp/translesion DNA polymerase binding surface; other site 637381008747 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 637381008748 hypothetical protein; Validated; Region: PRK06672 637381008749 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637381008750 Walker A motif; other site 637381008751 ATP binding site [chemical binding]; other site 637381008752 Walker B motif; other site 637381008753 arginine finger; other site 637381008754 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 637381008755 DnaA box-binding interface [nucleotide binding]; other site