-- dump date   	20111121_012900
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
568819000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
568819000002	hypothetical protein; Validated; Region: PRK06672
568819000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
568819000004	Walker A motif; other site
568819000005	ATP binding site [chemical binding]; other site
568819000006	Walker B motif; other site
568819000007	arginine finger; other site
568819000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
568819000009	DnaA box-binding interface [nucleotide binding]; other site
568819000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140
568819000011	DNA polymerase III beta subunit; Region: POL3Bc; smart00480
568819000012	putative DNA binding surface [nucleotide binding]; other site
568819000013	dimer interface [polypeptide binding]; other site
568819000014	beta-clamp/clamp loader binding surface; other site
568819000015	beta-clamp/translesion DNA polymerase binding surface; other site
568819000016	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
568819000017	MatE; Region: MatE; cl10513
568819000018	MatE; Region: MatE; cl10513
568819000019	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
568819000020	recombination protein F; Reviewed; Region: recF; PRK00064
568819000021	RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage.  When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242
568819000022	Walker A/P-loop; other site
568819000023	ATP binding site [chemical binding]; other site
568819000024	Q-loop/lid; other site
568819000025	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819000026	ABC transporter signature motif; other site
568819000027	Walker B; other site
568819000028	D-loop; other site
568819000029	H-loop/switch region; other site
568819000030	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
568819000031	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819000032	Mg2+ binding site [ion binding]; other site
568819000033	G-X-G motif; other site
568819000034	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822
568819000035	anchoring element; other site
568819000036	dimer interface [polypeptide binding]; other site
568819000037	ATP binding site [chemical binding]; other site
568819000038	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366
568819000039	active site
568819000040	putative metal-binding site [ion binding]; other site
568819000041	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
568819000042	DNA gyrase subunit A; Validated; Region: PRK05560
568819000043	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187
568819000044	CAP-like domain; other site
568819000045	Active site [active]
568819000046	primary dimer interface [polypeptide binding]; other site
568819000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
568819000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
568819000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
568819000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
568819000051	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
568819000052	cardiolipin synthetase; Reviewed; Region: PRK12452
568819000053	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
568819000054	putative active site [active]
568819000055	catalytic site [active]
568819000056	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
568819000057	putative active site [active]
568819000058	catalytic site [active]
568819000059	spermidine N1-acetyltransferase; Provisional; Region: PRK15130
568819000060	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
568819000061	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
568819000062	GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256
568819000063	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
568819000064	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
568819000065	GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256
568819000066	Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
568819000067	GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256
568819000070	cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432
568819000071	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
568819000072	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
568819000073	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
568819000074	D-pathway; other site
568819000075	Putative ubiquinol binding site [chemical binding]; other site
568819000076	Low-spin heme (heme b) binding site [chemical binding]; other site
568819000077	Putative water exit pathway; other site
568819000078	Binuclear center (heme o3/CuB) [ion binding]; other site
568819000079	K-pathway; other site
568819000080	Putative proton exit pathway; other site
568819000081	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
568819000082	Subunit I/III interface [polypeptide binding]; other site
568819000083	Subunit III/IV interface [polypeptide binding]; other site
568819000084	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
568819000085	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
568819000086	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
568819000087	putative active site [active]
568819000088	putative metal binding site [ion binding]; other site
568819000089	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046
568819000090	6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593
568819000091	Bacterial SH3 domain; Region: SH3_3; cl02551
568819000092	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
568819000093	putative active site [active]
568819000094	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
568819000095	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819000096	DNA-binding site [nucleotide binding]; DNA binding site
568819000097	UTRA domain; Region: UTRA; cl01230
568819000098	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006
568819000099	active pocket/dimerization site; other site
568819000100	active site
568819000101	phosphorylation site [posttranslational modification]
568819000102	Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four...; Region: PTS_IIB_man; cd00001
568819000103	active site
568819000104	phosphorylation site [posttranslational modification]
568819000105	PTS system sorbose-specific iic component; Region: EII-Sor; cl01506
568819000106	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
568819000107	hypothetical protein; Provisional; Region: PRK02947
568819000108	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013
568819000109	putative active site [active]
568819000110	CutC family; Region: CutC; cl01218
568819000111	PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824
568819000112	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212
568819000113	active site turn [active]
568819000114	phosphorylation site [posttranslational modification]
568819000115	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
568819000116	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cd00210
568819000117	HPr interaction site; other site
568819000118	glycerol kinase (GK) interaction site [polypeptide binding]; other site
568819000119	active site
568819000120	phosphorylation site [posttranslational modification]
568819000121	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
568819000122	putative dimer interface [polypeptide binding]; other site
568819000123	catalytic triad [active]
568819000124	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819000125	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
568819000126	Walker A/P-loop; other site
568819000127	ATP binding site [chemical binding]; other site
568819000128	Q-loop/lid; other site
568819000129	ABC transporter signature motif; other site
568819000130	Walker B; other site
568819000131	D-loop; other site
568819000132	H-loop/switch region; other site
568819000133	Protein of unknown function (DUF2705); Region: DUF2705; pfam10920
568819000136	Protein of unknown function (DUF2712); Region: DUF2712; pfam10916
568819000137	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
568819000138	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
568819000139	active site
568819000140	motif I; other site
568819000141	motif II; other site
568819000142	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
568819000143	Transcriptional regulators [Transcription]; Region: PurR; COG1609
568819000144	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568819000145	DNA binding site [nucleotide binding]
568819000146	domain linker motif; other site
568819000147	Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299
568819000148	dimerization interface [polypeptide binding]; other site
568819000149	putative ligand binding site [chemical binding]; other site
568819000150	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
568819000151	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
568819000152	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
568819000153	E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies.  These domains are associated with different types of catalytic domains at  either the N-terminal or C-terminal end; Region: E_set; cl09101
568819000154	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
568819000155	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
568819000156	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
568819000157	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
568819000158	dimer interface [polypeptide binding]; other site
568819000159	active site
568819000160	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
568819000161	dimer interface [polypeptide binding]; other site
568819000162	active site
568819000163	putrescine carbamoyltransferase; Provisional; Region: PRK02255
568819000164	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
568819000165	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819000166	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
568819000167	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113
568819000168	agmatine deiminase; Region: agmatine_aguA; TIGR03380
568819000169	carbamate kinase; Reviewed; Region: PRK12686
568819000170	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
568819000171	putative substrate binding site [chemical binding]; other site
568819000172	nucleotide binding site [chemical binding]; other site
568819000173	nucleotide binding site [chemical binding]; other site
568819000174	homodimer interface [polypeptide binding]; other site
568819000175	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113
568819000176	agmatine deiminase; Region: agmatine_aguA; TIGR03380
568819000177	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
568819000178	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013
568819000179	putative active site [active]
568819000180	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
568819000181	Amidinotransferase; Region: Amidinotransf; cl12043
568819000182	Arginine deiminase [Amino acid transport and metabolism]; Region: ArcA; COG2235
568819000183	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
568819000184	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
568819000185	dimer interface [polypeptide binding]; other site
568819000186	ssDNA binding site [nucleotide binding]; other site
568819000187	tetramer (dimer of dimers) interface [polypeptide binding]; other site
568819000188	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
568819000189	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
568819000190	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
568819000191	Accessory gene regulator B; Region: AgrB; cl01873
568819000192	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
568819000193	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
568819000194	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
568819000195	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
568819000196	active site
568819000197	phosphorylation site [posttranslational modification]
568819000198	intermolecular recognition site; other site
568819000199	LytTr DNA-binding domain; Region: LytTR; cl04498
568819000200	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
568819000201	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
568819000202	DHH family; Region: DHH; pfam01368
568819000203	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
568819000204	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
568819000205	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
568819000206	replicative DNA helicase; Provisional; Region: PRK05748
568819000207	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
568819000208	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
568819000209	Walker A motif; other site
568819000210	ATP binding site [chemical binding]; other site
568819000211	Walker B motif; other site
568819000212	DNA binding loops [nucleotide binding]
568819000213	adenylosuccinate synthetase; Provisional; Region: PRK01117
568819000214	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108
568819000215	GDP-binding site [chemical binding]; other site
568819000216	ACT binding site; other site
568819000217	IMP binding site; other site
568819000218	Proteins of 100 residues with WXG; Region: WXG100; cl02005
568819000219	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
568819000220	type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929
568819000221	Firmicute eSAT-6 protein secretion system EssA; Region: EssA; cl11266
568819000222	YukD; Region: YukD; cl11566
568819000223	Predicted membrane protein essB; Region: essB; cl01868
568819000224	DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538
568819000225	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
568819000226	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819000227	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819000228	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495
568819000231	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
568819000232	tetramer interface [polypeptide binding]; other site
568819000233	active site
568819000234	Mg2+/Mn2+ binding site [ion binding]; other site
568819000235	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
568819000236	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
568819000237	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
568819000238	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
568819000239	DNA binding site [nucleotide binding]
568819000240	active site
568819000241	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
568819000242	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
568819000243	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
568819000244	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819000245	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
568819000246	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
568819000247	DNA binding residues [nucleotide binding]
568819000248	putative dimer interface [polypeptide binding]; other site
568819000249	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
568819000250	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
568819000251	active site
568819000252	catalytic tetrad [active]
568819000253	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568819000254	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
568819000255	F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343
568819000256	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819000257	Walker A motif; other site
568819000258	ATP binding site [chemical binding]; other site
568819000259	Walker B motif; other site
568819000260	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
568819000261	ATP synthase; Region: ATP-synt; cl00365
568819000262	F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597
568819000263	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
568819000264	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
568819000265	alpha subunit interaction interface [polypeptide binding]; other site
568819000266	Walker A motif; other site
568819000267	ATP binding site [chemical binding]; other site
568819000268	Walker B motif; other site
568819000269	inhibitor binding site; inhibition site
568819000270	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
568819000271	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
568819000272	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
568819000273	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006
568819000274	active pocket/dimerization site; other site
568819000275	active site
568819000276	phosphorylation site [posttranslational modification]
568819000277	Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four...; Region: PTS_IIB_man; cd00001
568819000278	active site
568819000279	phosphorylation site [posttranslational modification]
568819000280	PTS system sorbose-specific iic component; Region: EII-Sor; cl01506
568819000281	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
568819000282	Domain of unknown function (DUF956); Region: DUF956; cl01917
568819000283	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; cl02047
568819000284	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156
568819000285	HOOK protein; Region: HOOK; pfam05622
568819000286	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568819000287	dimerization interface [polypeptide binding]; other site
568819000288	putative DNA binding site [nucleotide binding]; other site
568819000289	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
568819000290	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
568819000291	dimer interface [polypeptide binding]; other site
568819000292	FMN binding site [chemical binding]; other site
568819000293	Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325
568819000294	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is...; Region: GH18_chitinase; cd06548
568819000295	active site
568819000296	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
568819000297	Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046
568819000298	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
568819000299	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
568819000300	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
568819000301	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
568819000302	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
568819000303	Walker A/P-loop; other site
568819000304	ATP binding site [chemical binding]; other site
568819000305	Q-loop/lid; other site
568819000306	ABC transporter signature motif; other site
568819000307	Walker B; other site
568819000308	D-loop; other site
568819000309	H-loop/switch region; other site
568819000310	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
568819000311	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
568819000312	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
568819000313	Walker A/P-loop; other site
568819000314	ATP binding site [chemical binding]; other site
568819000315	Q-loop/lid; other site
568819000316	ABC transporter signature motif; other site
568819000317	Walker B; other site
568819000318	D-loop; other site
568819000319	H-loop/switch region; other site
568819000320	Cupin domain; Region: Cupin_2; cl09118
568819000321	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568819000322	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
568819000323	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568819000324	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
568819000325	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
568819000326	substrate binding pocket [chemical binding]; other site
568819000327	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
568819000328	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
568819000329	Domain of unknown function (DUF955); Region: DUF955; cl01076
568819000330	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568819000331	non-specific DNA binding site [nucleotide binding]; other site
568819000332	salt bridge; other site
568819000333	sequence-specific DNA binding site [nucleotide binding]; other site
568819000334	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
568819000335	Phage major tail protein 2; Region: Phage_tail_2; cl11463
568819000336	Phage-related protein [Function unknown]; Region: COG5412
568819000337	Phage tail protein; Region: Sipho_tail; cl11462
568819000338	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
568819000339	Holin family; Region: Phage_holin_4; cl01989
568819000340	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
568819000341	active site
568819000342	metal binding site [ion binding]; metal-binding site
568819000343	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
568819000344	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
568819000345	putative active site [active]
568819000346	putative metal binding site [ion binding]; other site
568819000347	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
568819000348	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
568819000349	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107
568819000350	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
568819000351	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH_2; cd04602
568819000352	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381
568819000353	active site
568819000354	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
568819000355	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
568819000356	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
568819000357	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
568819000358	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
568819000359	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819000360	dimer interface [polypeptide binding]; other site
568819000361	conserved gate region; other site
568819000362	putative PBP binding loops; other site
568819000363	ABC-ATPase subunit interface; other site
568819000364	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
568819000365	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
568819000366	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819000367	dimer interface [polypeptide binding]; other site
568819000368	conserved gate region; other site
568819000369	putative PBP binding loops; other site
568819000370	ABC-ATPase subunit interface; other site
568819000371	Protein of unknown function (DUF3130; Region: DUF3130; pfam11328
568819000372	Bacillus transposase protein; Region: Transposase_30; pfam04740
568819000373	ADP-ribosyl cyclase (also known as cyclic ADP-ribose hydrolase or CD38) synthesizes the second messenger cyclic-ADP ribose (cADPR), which in turn releases calcium from internal stores. Mammals possess two membrane proteins, CD38 and BST-1/CD157, which...; Region: Rib_hydrolase; cl08346
568819000375	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
568819000376	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
568819000377	peptide binding site [polypeptide binding]; other site
568819000378	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
568819000379	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
568819000380	metal binding site [ion binding]; metal-binding site
568819000381	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
568819000382	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235
568819000383	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
568819000384	ABC-ATPase subunit  interface; other site
568819000385	dimer interface [polypeptide binding]; other site
568819000386	putative PBP binding regions; other site
568819000387	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568819000388	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
568819000389	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
568819000390	DEAD_2; Region: DEAD_2; cl14887
568819000391	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819000392	sugar phosphate phosphatase; Provisional; Region: PRK10513
568819000393	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
568819000394	active site
568819000395	motif I; other site
568819000396	motif II; other site
568819000397	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
568819000398	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
568819000399	Collagen binding domain; Region: Collagen_bind; pfam05737
568819000400	Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619
568819000401	Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619
568819000402	Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619
568819000405	Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
568819000406	DNA polymerase III subunit delta'; Validated; Region: PRK08058
568819000407	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819000408	PSP1 C-terminal conserved region; Region: PSP1; cl00770
568819000409	Protein of unknown function (DUF972); Region: DUF972; cl01853
568819000410	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
568819000411	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
568819000412	S-adenosylmethionine binding site [chemical binding]; other site
568819000413	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
568819000414	GIY-YIG motif/motif A; other site
568819000415	putative active site [active]
568819000416	putative metal binding site [ion binding]; other site
568819000417	Predicted methyltransferases [General function prediction only]; Region: COG0313
568819000418	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
568819000419	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
568819000420	SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877
568819000421	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
568819000422	Uncharacterized conserved protein [Function unknown]; Region: COG5361
568819000423	Protein of unknown function (DUF1254); Region: DUF1254; cl02257
568819000424	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
568819000425	MucBP domain; Region: MucBP; pfam06458
568819000426	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
568819000427	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
568819000428	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
568819000429	active site
568819000430	HIGH motif; other site
568819000431	KMSKS motif; other site
568819000432	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
568819000433	tRNA binding surface [nucleotide binding]; other site
568819000434	anticodon binding site; other site
568819000435	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
568819000436	dimer interface [polypeptide binding]; other site
568819000437	putative tRNA-binding site [nucleotide binding]; other site
568819000438	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819000439	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
568819000440	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
568819000441	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
568819000442	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819000443	dimer interface [polypeptide binding]; other site
568819000444	conserved gate region; other site
568819000445	putative PBP binding loops; other site
568819000446	ABC-ATPase subunit interface; other site
568819000447	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
568819000448	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819000449	dimer interface [polypeptide binding]; other site
568819000450	conserved gate region; other site
568819000451	putative PBP binding loops; other site
568819000452	ABC-ATPase subunit interface; other site
568819000453	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
568819000454	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
568819000455	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
568819000456	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402
568819000457	active site
568819000458	catalytic site [active]
568819000459	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
568819000460	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
568819000461	trimer interface [polypeptide binding]; other site
568819000462	active site
568819000463	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
568819000464	catalytic site [active]
568819000465	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
568819000466	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
568819000467	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
568819000468	putative deoxyribonuclease YjjV; Provisional; Region: PRK11449
568819000469	active site
568819000470	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
568819000471	Domain of unknown function (DUF348); Region: DUF348; pfam03990
568819000472	Domain of unknown function (DUF348); Region: DUF348; pfam03990
568819000473	G5 domain; Region: G5; pfam07501
568819000474	3D domain; Region: 3D; cl01439
568819000475	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
568819000476	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in...; Region: TOPRIM_RNase_M5_like; cd01027
568819000477	putative active site [active]
568819000478	putative metal binding site [ion binding]; other site
568819000479	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
568819000480	Protein of unknown function (DUF1021); Region: DUF1021; cl01852
568819000481	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
568819000482	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
568819000483	YdjC-like protein; Region: YdjC; cl01344
568819000484	pur operon repressor; Provisional; Region: PRK09213
568819000485	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
568819000486	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
568819000487	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
568819000488	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
568819000489	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
568819000490	Walker A/P-loop; other site
568819000491	ATP binding site [chemical binding]; other site
568819000492	Q-loop/lid; other site
568819000493	ABC transporter signature motif; other site
568819000494	Walker B; other site
568819000495	D-loop; other site
568819000496	H-loop/switch region; other site
568819000497	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
568819000498	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
568819000499	FtsX-like permease family; Region: FtsX; pfam02687
568819000500	SpoVG; Region: SpoVG; cl00915
568819000501	SpoVG; Region: SpoVG; cl00915
568819000502	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
568819000503	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
568819000504	Substrate binding site [chemical binding]; other site
568819000505	Mg++ binding site [ion binding]; other site
568819000506	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
568819000507	active site
568819000508	substrate binding site [chemical binding]; other site
568819000509	CoA binding site [chemical binding]; other site
568819000510	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269
568819000511	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
568819000512	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568819000513	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
568819000514	Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137
568819000515	active site
568819000516	catalytic site [active]
568819000517	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
568819000518	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
568819000519	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
568819000520	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
568819000521	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
568819000522	active site
568819000523	Zn binding site [ion binding]; other site
568819000524	ActA Protein; Region: ActA; pfam05058
568819000525	Zinc dependent phospholipase C; Region: Zn_dep_PLPC; cl03005
568819000526	Protein of unknown function (DUF1307); Region: DUF1307; cl01981
568819000527	Domain of unknown function (DUF74); Region: DUF74; cl00426
568819000528	A new structural DNA glycosylase; Region: AlkD_like; cd06561
568819000529	Active site [active]
568819000530	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
568819000531	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
568819000532	tetramer (dimer of dimers) interface [polypeptide binding]; other site
568819000533	NAD binding site [chemical binding]; other site
568819000534	dimer interface [polypeptide binding]; other site
568819000535	substrate binding site [chemical binding]; other site
568819000536	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
568819000537	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
568819000538	5S rRNA interface [nucleotide binding]; other site
568819000539	CTC domain interface [polypeptide binding]; other site
568819000540	L16 interface [polypeptide binding]; other site
568819000541	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
568819000542	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
568819000543	putative active site [active]
568819000544	catalytic residue [active]
568819000545	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
568819000546	CarD-like/TRCF domain; Region: CarD_TRCF; cl00588
568819000547	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
568819000548	ATP binding site [chemical binding]; other site
568819000549	putative Mg++ binding site [ion binding]; other site
568819000550	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568819000551	nucleotide binding region [chemical binding]; other site
568819000552	ATP-binding site [chemical binding]; other site
568819000553	TRCF domain; Region: TRCF; cl04088
568819000554	stage V sporulation protein B; Region: spore_V_B; TIGR02900
568819000555	MatE; Region: MatE; cl10513
568819000556	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
568819000557	Septum formation initiator; Region: DivIC; cl11433
568819000558	hypothetical protein; Provisional; Region: PRK08582
568819000559	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692
568819000560	RNA binding site [nucleotide binding]; other site
568819000561	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
568819000562	Ligand Binding Site [chemical binding]; other site
568819000563	B3/4 domain; Region: B3_4; cl11458
568819000564	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
568819000565	FtsH Extracellular; Region: FtsH_ext; pfam06480
568819000566	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
568819000567	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
568819000568	Walker A motif; other site
568819000569	ATP binding site [chemical binding]; other site
568819000570	Walker B motif; other site
568819000571	arginine finger; other site
568819000572	Peptidase family M41; Region: Peptidase_M41; pfam01434
568819000573	Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130
568819000574	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
568819000575	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
568819000576	dimerization interface [polypeptide binding]; other site
568819000577	domain crossover interface; other site
568819000578	redox-dependent activation switch; other site
568819000579	cysteine synthases; Region: cysKM; TIGR01136
568819000580	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561
568819000581	dimer interface [polypeptide binding]; other site
568819000582	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819000583	catalytic residue [active]
568819000584	dihydropteroate synthase; Region: DHPS; TIGR01496
568819000585	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
568819000586	substrate binding pocket [chemical binding]; other site
568819000587	dimer interface [polypeptide binding]; other site
568819000588	inhibitor binding site; inhibition site
568819000589	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines...; Region: DHNA_DHNTPE; cd00534
568819000590	homooctamer interface [polypeptide binding]; other site
568819000591	active site
568819000592	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
568819000593	catalytic center binding site [active]
568819000594	ATP binding site [chemical binding]; other site
568819000595	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
568819000596	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801
568819000597	FMN binding site [chemical binding]; other site
568819000598	active site
568819000599	catalytic residues [active]
568819000600	substrate binding site [chemical binding]; other site
568819000601	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
568819000602	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322
568819000603	dimer interface [polypeptide binding]; other site
568819000604	putative anticodon binding site; other site
568819000605	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
568819000606	motif 1; other site
568819000607	active site
568819000608	motif 2; other site
568819000609	motif 3; other site
568819000610	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850
568819000611	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
568819000612	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
568819000613	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
568819000614	ADP binding site [chemical binding]; other site
568819000615	phosphagen binding site; other site
568819000616	substrate specificity loop; other site
568819000617	Clp protease ATP binding subunit; Region: clpC; CHL00095
568819000618	Clp amino terminal domain; Region: Clp_N; pfam02861
568819000619	Clp amino terminal domain; Region: Clp_N; pfam02861
568819000620	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
568819000621	Walker A motif; other site
568819000622	ATP binding site [chemical binding]; other site
568819000623	Walker B motif; other site
568819000624	arginine finger; other site
568819000625	UvrB/uvrC motif; Region: UVR; pfam02151
568819000626	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
568819000627	Walker A motif; other site
568819000628	ATP binding site [chemical binding]; other site
568819000629	Walker B motif; other site
568819000630	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
568819000631	DNA repair protein RadA; Provisional; Region: PRK11823
568819000632	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
568819000633	Walker A motif/ATP binding site; other site
568819000634	ATP binding site [chemical binding]; other site
568819000635	Walker B motif; other site
568819000636	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
568819000637	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
568819000638	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
568819000639	putative active site [active]
568819000640	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
568819000641	substrate binding site [chemical binding]; other site
568819000642	dimer interface [polypeptide binding]; other site
568819000643	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554
568819000644	homotrimer interaction site [polypeptide binding]; other site
568819000645	zinc binding site [ion binding]; other site
568819000646	CDP-binding sites; other site
568819000647	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
568819000648	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
568819000649	HIGH motif; other site
568819000650	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
568819000651	active site
568819000652	KMSKS motif; other site
568819000653	serine O-acetyltransferase; Region: cysE; TIGR01172
568819000654	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354
568819000655	trimer interface [polypeptide binding]; other site
568819000656	active site
568819000657	substrate binding site [chemical binding]; other site
568819000658	CoA binding site [chemical binding]; other site
568819000659	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
568819000660	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
568819000661	active site
568819000662	HIGH motif; other site
568819000663	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
568819000664	KMSKS motif; other site
568819000665	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
568819000666	tRNA binding surface [nucleotide binding]; other site
568819000667	anticodon binding site; other site
568819000668	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593
568819000669	active site
568819000670	metal binding site [ion binding]; metal-binding site
568819000671	dimerization interface [polypeptide binding]; other site
568819000672	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
568819000673	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
568819000674	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
568819000675	YacP-like NYN domain; Region: NYN_YacP; cl01491
568819000676	RNA polymerase factor sigma-70; Validated; Region: PRK08295
568819000677	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
568819000678	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
568819000679	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
568819000680	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
568819000681	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
568819000682	putative homodimer interface [polypeptide binding]; other site
568819000683	KOW motif; Region: KOW; cl00354
568819000684	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
568819000685	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
568819000686	23S rRNA interface [nucleotide binding]; other site
568819000687	L7/L12 interface [polypeptide binding]; other site
568819000688	putative thiostrepton binding site; other site
568819000689	L25 interface [polypeptide binding]; other site
568819000690	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403
568819000691	mRNA/rRNA interface [nucleotide binding]; other site
568819000692	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797
568819000693	23S rRNA interface [nucleotide binding]; other site
568819000694	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
568819000695	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
568819000696	core dimer interface [polypeptide binding]; other site
568819000697	peripheral dimer interface [polypeptide binding]; other site
568819000698	L10 interface [polypeptide binding]; other site
568819000699	L11 interface [polypeptide binding]; other site
568819000700	putative EF-Tu interaction site [polypeptide binding]; other site
568819000701	putative EF-G interaction site [polypeptide binding]; other site
568819000702	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
568819000703	S-adenosylmethionine binding site [chemical binding]; other site
568819000704	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032
568819000705	release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073
568819000706	Transcriptional regulators [Transcription]; Region: PurR; COG1609
568819000707	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568819000708	DNA binding site [nucleotide binding]
568819000709	domain linker motif; other site
568819000710	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
568819000711	putative dimerization interface [polypeptide binding]; other site
568819000712	putative ligand binding site [chemical binding]; other site
568819000713	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
568819000714	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
568819000715	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
568819000716	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819000717	dimer interface [polypeptide binding]; other site
568819000718	conserved gate region; other site
568819000719	putative PBP binding loops; other site
568819000720	ABC-ATPase subunit interface; other site
568819000721	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
568819000722	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819000723	dimer interface [polypeptide binding]; other site
568819000724	conserved gate region; other site
568819000725	putative PBP binding loops; other site
568819000726	ABC-ATPase subunit interface; other site
568819000727	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
568819000728	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
568819000729	sucrose phosphorylase; Provisional; Region: PRK13840
568819000730	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
568819000731	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
568819000732	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
568819000733	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
568819000734	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
568819000735	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
568819000736	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
568819000737	RPB10 interaction site [polypeptide binding]; other site
568819000738	RPB1 interaction site [polypeptide binding]; other site
568819000739	RPB11 interaction site [polypeptide binding]; other site
568819000740	RPB3 interaction site [polypeptide binding]; other site
568819000741	RPB12 interaction site [polypeptide binding]; other site
568819000742	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
568819000743	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
568819000744	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
568819000745	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
568819000746	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
568819000747	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
568819000748	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
568819000749	G-loop; other site
568819000750	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
568819000751	DNA binding site [nucleotide binding]
568819000752	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
568819000753	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
568819000754	active site
568819000755	motif I; other site
568819000756	motif II; other site
568819000757	6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593
568819000758	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046
568819000759	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
568819000760	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819000761	Walker A/P-loop; other site
568819000762	ATP binding site [chemical binding]; other site
568819000763	Q-loop/lid; other site
568819000764	ABC transporter signature motif; other site
568819000765	Walker B; other site
568819000766	D-loop; other site
568819000767	H-loop/switch region; other site
568819000768	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
568819000769	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819000770	Walker A/P-loop; other site
568819000771	ATP binding site [chemical binding]; other site
568819000772	Q-loop/lid; other site
568819000773	ABC transporter signature motif; other site
568819000774	Walker B; other site
568819000775	D-loop; other site
568819000776	H-loop/switch region; other site
568819000777	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
568819000778	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
568819000779	LRR adjacent; Region: LRR_adjacent; pfam08191
568819000780	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
568819000781	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
568819000782	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
568819000783	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
568819000784	LRR adjacent; Region: LRR_adjacent; pfam08191
568819000785	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
568819000786	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
568819000787	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
568819000788	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819000789	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309
568819000790	Leucine-rich repeats; other site
568819000791	Substrate binding site [chemical binding]; other site
568819000792	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819000793	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819000794	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819000795	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819000796	LRR adjacent; Region: LRR_adjacent; pfam08191
568819000797	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
568819000798	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
568819000799	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
568819000800	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
568819000801	metal binding site [ion binding]; metal-binding site
568819000802	dimer interface [polypeptide binding]; other site
568819000803	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819000804	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
568819000805	Zn binding site [ion binding]; other site
568819000806	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
568819000807	Zn binding site [ion binding]; other site
568819000808	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
568819000809	Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300
568819000810	catalytic core [active]
568819000811	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
568819000812	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819000813	dimer interface [polypeptide binding]; other site
568819000814	conserved gate region; other site
568819000815	ABC-ATPase subunit interface; other site
568819000816	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
568819000817	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309
568819000818	SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747
568819000819	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046
568819000820	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
568819000821	sugar phosphate phosphatase; Provisional; Region: PRK10513
568819000822	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
568819000823	active site
568819000824	motif I; other site
568819000825	motif II; other site
568819000826	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
568819000827	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
568819000828	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568819000829	Coenzyme A binding pocket [chemical binding]; other site
568819000830	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568819000831	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
568819000832	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
568819000833	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
568819000834	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
568819000835	active site
568819000836	motif I; other site
568819000837	motif II; other site
568819000838	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
568819000839	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819000840	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
568819000841	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
568819000842	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
568819000843	Walker A/P-loop; other site
568819000844	ATP binding site [chemical binding]; other site
568819000845	Q-loop/lid; other site
568819000846	ABC transporter signature motif; other site
568819000847	Walker B; other site
568819000848	D-loop; other site
568819000849	H-loop/switch region; other site
568819000850	TOBE domain; Region: TOBE_2; cl01440
568819000851	ATP cone domain; Region: ATP-cone; pfam03477
568819000852	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
568819000853	Class III ribonucleotide reductase; Region: RNR_III; cd01675
568819000854	effector binding site; other site
568819000855	active site
568819000856	Zn binding site [ion binding]; other site
568819000857	glycine loop; other site
568819000858	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
568819000859	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259
568819000860	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568819000861	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
568819000862	Predicted amidohydrolase [General function prediction only]; Region: COG0388
568819000863	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
568819000864	putative active site [active]
568819000865	catalytic triad [active]
568819000866	putative dimer interface [polypeptide binding]; other site
568819000867	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819000868	dimer interface [polypeptide binding]; other site
568819000869	conserved gate region; other site
568819000870	ABC-ATPase subunit interface; other site
568819000871	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
568819000872	MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport.  Other members of this system include the MetP permease and  the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258
568819000873	Walker A/P-loop; other site
568819000874	ATP binding site [chemical binding]; other site
568819000875	Q-loop/lid; other site
568819000876	ABC transporter signature motif; other site
568819000877	Walker B; other site
568819000878	D-loop; other site
568819000879	H-loop/switch region; other site
568819000880	NIL domain; Region: NIL; cl09633
568819000881	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
568819000882	aspartate aminotransferase; Provisional; Region: PRK07681
568819000883	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
568819000884	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819000885	homodimer interface [polypeptide binding]; other site
568819000886	catalytic residue [active]
568819000887	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568819000888	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
568819000889	active site
568819000890	phosphorylation site [posttranslational modification]
568819000891	intermolecular recognition site; other site
568819000892	dimerization interface [polypeptide binding]; other site
568819000893	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
568819000894	DNA binding site [nucleotide binding]
568819000895	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
568819000896	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
568819000897	dimerization interface [polypeptide binding]; other site
568819000898	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
568819000899	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
568819000900	dimer interface [polypeptide binding]; other site
568819000901	phosphorylation site [posttranslational modification]
568819000902	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819000903	ATP binding site [chemical binding]; other site
568819000904	Mg2+ binding site [ion binding]; other site
568819000905	G-X-G motif; other site
568819000906	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
568819000907	YycH protein; Region: YycH; pfam07435
568819000908	YycH protein; Region: YycI; cl02015
568819000909	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
568819000910	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
568819000911	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149
568819000912	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
568819000913	protein binding site [polypeptide binding]; other site
568819000914	Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679
568819000915	Transcriptional regulator [Transcription]; Region: LysR; COG0583
568819000916	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819000917	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
568819000918	dimerization interface [polypeptide binding]; other site
568819000919	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH...; Region: NfsA_FRP; cd02146
568819000920	dimer interface [polypeptide binding]; other site
568819000921	FMN binding site [chemical binding]; other site
568819000922	NADPH bind site [chemical binding]; other site
568819000923	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
568819000924	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819000925	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819000926	PRD domain; Region: PRD; pfam00874
568819000927	PRD domain; Region: PRD; pfam00874
568819000928	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
568819000929	P-loop; other site
568819000930	active site
568819000931	phosphorylation site [posttranslational modification]
568819000932	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819000933	active site
568819000934	phosphorylation site [posttranslational modification]
568819000935	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
568819000936	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564
568819000937	active site
568819000938	P-loop; other site
568819000939	phosphorylation site [posttranslational modification]
568819000940	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046
568819000941	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
568819000942	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
568819000943	methionine cluster; other site
568819000944	active site
568819000945	phosphorylation site [posttranslational modification]
568819000946	metal binding site [ion binding]; metal-binding site
568819000947	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
568819000948	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
568819000949	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
568819000950	catalytic residue [active]
568819000951	YdjC-like protein; Region: YdjC; cl01344
568819000952	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243
568819000953	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
568819000954	substrate binding site [chemical binding]; other site
568819000955	multimerization interface [polypeptide binding]; other site
568819000956	ATP binding site [chemical binding]; other site
568819000957	bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427
568819000958	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
568819000959	dimer interface [polypeptide binding]; other site
568819000960	substrate binding site [chemical binding]; other site
568819000961	ATP binding site [chemical binding]; other site
568819000962	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564
568819000963	thiamine phosphate binding site [chemical binding]; other site
568819000964	active site
568819000965	pyrophosphate binding site [ion binding]; other site
568819000966	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046
568819000967	6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593
568819000968	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
568819000969	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515
568819000970	Protein of unknown function (DUF1696); Region: DUF1696; pfam08000
568819000971	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
568819000972	putative catalytic site [active]
568819000973	putative metal binding site [ion binding]; other site
568819000974	putative phosphate binding site [ion binding]; other site
568819000975	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568819000976	non-specific DNA binding site [nucleotide binding]; other site
568819000977	salt bridge; other site
568819000978	sequence-specific DNA binding site [nucleotide binding]; other site
568819000979	C-terminal domain; Region: RGG_Cterm; TIGR01716
568819000980	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
568819000981	C-terminal domain; Region: RGG_Cterm; TIGR01716
568819000982	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
568819000983	E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370
568819000984	Gram-positive; Region: pullulan_Gpos; TIGR02102
568819000985	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
568819000986	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
568819000987	LRR adjacent; Region: LRR_adjacent; pfam08191
568819000988	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
568819000989	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309
568819000990	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819000991	Leucine-rich repeats; other site
568819000992	Substrate binding site [chemical binding]; other site
568819000993	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819000994	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819000995	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309
568819000996	Leucine-rich repeats; other site
568819000997	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819000998	Substrate binding site [chemical binding]; other site
568819000999	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001000	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001001	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001002	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001003	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001004	LRR adjacent; Region: LRR_adjacent; pfam08191
568819001005	MucBP domain; Region: MucBP; pfam06458
568819001006	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
568819001007	Protein of unknown function (DUF3130; Region: DUF3130; pfam11328
568819001008	Bacillus transposase protein; Region: Transposase_30; pfam04740
568819001009	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
568819001010	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
568819001011	TPP-binding site [chemical binding]; other site
568819001012	dimer interface [polypeptide binding]; other site
568819001013	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
568819001014	PYR/PP interface [polypeptide binding]; other site
568819001015	dimer interface [polypeptide binding]; other site
568819001016	TPP binding site [chemical binding]; other site
568819001017	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
568819001018	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
568819001019	active site
568819001020	intersubunit interactions; other site
568819001021	catalytic residue [active]
568819001022	short chain dehydrogenase; Provisional; Region: PRK06841
568819001023	classical (c) SDRs; Region: SDR_c; cd05233
568819001024	NAD(P) binding site [chemical binding]; other site
568819001025	active site
568819001026	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
568819001027	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
568819001028	substrate binding site [chemical binding]; other site
568819001029	dimer interface [polypeptide binding]; other site
568819001030	catalytic triad [active]
568819001031	DAK2 domain; Region: Dak2; cl03685
568819001032	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
568819001033	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
568819001034	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cl00025
568819001035	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
568819001036	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819001037	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
568819001038	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
568819001039	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
568819001040	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
568819001041	LRR adjacent; Region: LRR_adjacent; pfam08191
568819001042	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
568819001043	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
568819001044	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
568819001045	fumarate reductase flavoprotein subunit; Validated; Region: PRK06481
568819001046	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819001047	putative oxidoreductase; Provisional; Region: PRK10206
568819001048	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819001049	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
568819001050	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819001051	active site
568819001052	phosphorylation site [posttranslational modification]
568819001053	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
568819001054	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569
568819001055	P-loop; other site
568819001056	active site
568819001057	phosphorylation site [posttranslational modification]
568819001058	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
568819001059	hypothetical protein; Provisional; Region: PRK08185
568819001060	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947
568819001061	intersubunit interface [polypeptide binding]; other site
568819001062	active site
568819001063	zinc binding site [ion binding]; other site
568819001064	Na+ binding site [ion binding]; other site
568819001065	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
568819001066	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819001067	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
568819001068	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
568819001069	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
568819001070	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
568819001071	conserved cys residue [active]
568819001072	Predicted transcriptional regulator [Transcription]; Region: COG2378
568819001073	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819001074	Iron permease FTR1 family; Region: FTR1; cl00475
568819001075	Imelysin; Region: Peptidase_M75; cl09159
568819001076	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
568819001077	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
568819001078	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693
568819001079	nudix motif; other site
568819001080	Domain of unknown function DUF28; Region: DUF28; cl00361
568819001081	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
568819001082	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
568819001083	PhnA protein; Region: PhnA; pfam03831
568819001084	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
568819001085	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819001086	DNA-binding site [nucleotide binding]; DNA binding site
568819001087	UTRA domain; Region: UTRA; cl01230
568819001088	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046
568819001089	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
568819001090	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
568819001091	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564
568819001092	active site
568819001093	P-loop; other site
568819001094	phosphorylation site [posttranslational modification]
568819001095	Predicted transcriptional regulator [Transcription]; Region: COG2378
568819001096	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819001097	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368
568819001100	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
568819001101	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819001102	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
568819001103	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
568819001104	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
568819001105	tetrameric interface [polypeptide binding]; other site
568819001106	NAD binding site [chemical binding]; other site
568819001107	catalytic residues [active]
568819001108	KduI/IolB family; Region: KduI; cl01508
568819001109	pfkB family carbohydrate kinase; Region: PfkB; pfam00294
568819001110	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
568819001111	substrate binding site [chemical binding]; other site
568819001112	ATP binding site [chemical binding]; other site
568819001113	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
568819001114	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
568819001115	PYR/PP interface [polypeptide binding]; other site
568819001116	dimer interface [polypeptide binding]; other site
568819001117	TPP binding site [chemical binding]; other site
568819001118	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
568819001119	TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
568819001120	TPP-binding site; other site
568819001121	Protein of unknown function (DUF419); Region: DUF419; cl15265
568819001122	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
568819001123	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
568819001124	ligand binding site [chemical binding]; other site
568819001125	active site
568819001126	UGI interface [polypeptide binding]; other site
568819001127	catalytic site [active]
568819001128	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
568819001129	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4864
568819001130	SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057
568819001131	SH3 domain protein [Signal transduction mechanisms]; Region: COG3103
568819001132	NlpC/P60 family; Region: NLPC_P60; cl11438
568819001134	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
568819001135	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819001136	Transcriptional regulators [Transcription]; Region: GntR; COG1802
568819001137	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819001138	DNA-binding site [nucleotide binding]; DNA binding site
568819001139	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
568819001140	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
568819001141	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
568819001142	Walker A/P-loop; other site
568819001143	ATP binding site [chemical binding]; other site
568819001144	Q-loop/lid; other site
568819001145	ABC transporter signature motif; other site
568819001146	Walker B; other site
568819001147	D-loop; other site
568819001148	H-loop/switch region; other site
568819001149	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
568819001150	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
568819001151	FtsX-like permease family; Region: FtsX; pfam02687
568819001152	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
568819001153	putative hydrophobic ligand binding site [chemical binding]; other site
568819001154	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819001155	active site
568819001156	phosphorylation site [posttranslational modification]
568819001157	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569
568819001158	P-loop; other site
568819001159	active site
568819001160	phosphorylation site [posttranslational modification]
568819001161	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
568819001162	alpha-mannosidase; Provisional; Region: PRK09819
568819001163	Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074
568819001164	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
568819001165	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
568819001166	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819001167	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819001168	PRD domain; Region: PRD; pfam00874
568819001169	PRD domain; Region: PRD; pfam00874
568819001170	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
568819001171	P-loop; other site
568819001172	active site
568819001173	phosphorylation site [posttranslational modification]
568819001174	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819001175	active site
568819001176	phosphorylation site [posttranslational modification]
568819001177	Phosphate transporter family; Region: PHO4; cl00396
568819001178	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
568819001179	putative metal binding site [ion binding]; other site
568819001180	Protein of unknown function (DUF1149); Region: DUF1149; cl11551
568819001181	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
568819001182	trimer interface [polypeptide binding]; other site
568819001183	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
568819001184	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
568819001185	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309
568819001186	Leucine-rich repeats; other site
568819001187	Substrate binding site [chemical binding]; other site
568819001188	LRR adjacent; Region: LRR_adjacent; pfam08191
568819001189	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
568819001190	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
568819001191	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
568819001192	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
568819001193	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
568819001194	phosphoenolpyruvate synthase; Validated; Region: PRK06241
568819001195	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
568819001196	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
568819001197	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
568819001198	ZIP Zinc transporter; Region: Zip; pfam02535
568819001199	Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061
568819001200	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568819001201	non-specific DNA binding site [nucleotide binding]; other site
568819001202	salt bridge; other site
568819001203	sequence-specific DNA binding site [nucleotide binding]; other site
568819001204	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
568819001205	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
568819001206	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
568819001207	active site
568819001208	motif I; other site
568819001209	motif II; other site
568819001210	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
568819001211	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
568819001212	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
568819001213	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819001214	PRD domain; Region: PRD; pfam00874
568819001215	PRD domain; Region: PRD; pfam00874
568819001216	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
568819001217	P-loop; other site
568819001218	active site
568819001219	phosphorylation site [posttranslational modification]
568819001220	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819001221	active site
568819001222	phosphorylation site [posttranslational modification]
568819001223	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819001224	active site
568819001225	phosphorylation site [posttranslational modification]
568819001226	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569
568819001227	P-loop; other site
568819001228	active site
568819001229	phosphorylation site [posttranslational modification]
568819001230	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
568819001231	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
568819001232	Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074
568819001233	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
568819001234	Transcriptional regulator [Transcription]; Region: LysR; COG0583
568819001235	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819001236	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
568819001237	dimerization interface [polypeptide binding]; other site
568819001238	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
568819001239	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
568819001240	active site
568819001241	substrate binding site [chemical binding]; other site
568819001242	trimer interface [polypeptide binding]; other site
568819001243	CoA binding site [chemical binding]; other site
568819001244	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
568819001245	classical (c) SDRs; Region: SDR_c; cd05233
568819001246	NAD(P) binding site [chemical binding]; other site
568819001247	active site
568819001249	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
568819001250	RHS Repeat; Region: RHS_repeat; cl11982
568819001251	RHS Repeat; Region: RHS_repeat; cl11982
568819001252	RHS Repeat; Region: RHS_repeat; cl11982
568819001253	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
568819001254	adenylate kinase; Provisional; Region: PRK13808
568819001256	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
568819001257	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
568819001258	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001259	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
568819001260	LRR adjacent; Region: LRR_adjacent; pfam08191
568819001261	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
568819001262	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
568819001263	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
568819001264	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
568819001265	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001266	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309
568819001267	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001268	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001269	LRR adjacent; Region: LRR_adjacent; pfam08191
568819001270	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
568819001271	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
568819001272	Predicted transcriptional regulator [Transcription]; Region: COG1959
568819001273	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819001274	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819001275	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
568819001276	NAD(P) binding site [chemical binding]; other site
568819001277	active site
568819001278	Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908
568819001279	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
568819001280	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
568819001281	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
568819001282	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
568819001283	Protein of unknown function (DUF1275); Region: DUF1275; cl01453
568819001284	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
568819001285	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
568819001286	Protein of unknown function DUF58; Region: DUF58; pfam01882
568819001287	MoxR-like ATPases [General function prediction only]; Region: COG0714
568819001288	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819001289	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
568819001290	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
568819001291	Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457
568819001292	Sodium:solute symporter family; Region: SSF; cl00456
568819001293	Uncharacterized conserved protein [Function unknown]; Region: COG3535
568819001294	Protein of unknown function (DUF917); Region: DUF917; pfam06032
568819001295	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
568819001296	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668
568819001297	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819001298	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
568819001299	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001300	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001301	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
568819001302	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001303	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001304	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001305	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001306	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
568819001307	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
568819001308	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001309	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001310	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001311	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
568819001312	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001313	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001314	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001315	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001316	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001317	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
568819001318	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
568819001319	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001320	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001321	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001322	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001323	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
568819001324	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
568819001325	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
568819001326	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
568819001327	Protein of unknown function (DUF3139); Region: DUF3139; pfam11337
568819001328	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
568819001329	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568819001330	Myosin-crossreactive antigen [Function unknown]; Region: COG4716
568819001331	Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl01939
568819001332	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
568819001333	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
568819001334	FeS/SAM binding site; other site
568819001335	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368
568819001336	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
568819001337	Bacillus transposase protein; Region: Transposase_30; pfam04740
568819001338	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a beta-...; Region: Arsenite_oxidase; cd02135
568819001339	putative FMN binding site [chemical binding]; other site
568819001340	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
568819001341	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447
568819001342	nudix motif; other site
568819001343	Transcriptional regulator [Transcription]; Region: LysR; COG0583
568819001344	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819001345	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
568819001346	putative dimerization interface [polypeptide binding]; other site
568819001347	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
568819001348	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as...; Region: OYE_like_FMN_family; cd02803
568819001349	active site
568819001350	FMN binding site [chemical binding]; other site
568819001351	substrate binding site [chemical binding]; other site
568819001352	putative catalytic residue [active]
568819001353	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819001354	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
568819001355	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819001356	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
568819001357	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
568819001358	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
568819001359	shikimate binding site; other site
568819001360	NAD(P) binding site [chemical binding]; other site
568819001361	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
568819001362	3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093
568819001363	active site
568819001364	catalytic residue [active]
568819001365	dimer interface [polypeptide binding]; other site
568819001366	Transcriptional regulator [Transcription]; Region: LysR; COG0583
568819001367	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819001368	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
568819001369	dimerization interface [polypeptide binding]; other site
568819001370	substrate binding pocket [chemical binding]; other site
568819001371	Predicted acyl esterases [General function prediction only]; Region: COG2936
568819001372	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
568819001373	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
568819001374	active site
568819001375	catalytic triad [active]
568819001376	oxyanion hole [active]
568819001377	EamA-like transporter family; Region: EamA; cl01037
568819001378	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
568819001379	EamA-like transporter family; Region: EamA; cl01037
568819001380	Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722
568819001381	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
568819001382	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
568819001383	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429
568819001384	substrate binding site [chemical binding]; other site
568819001385	hexamer interface [polypeptide binding]; other site
568819001386	metal binding site [ion binding]; metal-binding site
568819001387	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
568819001388	catalytic residue [active]
568819001389	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
568819001390	PRD domain; Region: PRD; pfam00874
568819001391	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
568819001392	P-loop; other site
568819001393	active site
568819001394	phosphorylation site [posttranslational modification]
568819001395	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819001396	active site
568819001397	phosphorylation site [posttranslational modification]
568819001398	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-...; Region: SIS_Kpsf; cd05014
568819001399	putative active site [active]
568819001400	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819001401	active site
568819001402	phosphorylation site [posttranslational modification]
568819001403	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
568819001404	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429
568819001405	substrate binding site [chemical binding]; other site
568819001406	hexamer interface [polypeptide binding]; other site
568819001407	metal binding site [ion binding]; metal-binding site
568819001408	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
568819001409	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
568819001410	putative NAD(P) binding site [chemical binding]; other site
568819001411	catalytic Zn binding site [ion binding]; other site
568819001412	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
568819001413	P-loop; other site
568819001414	active site
568819001415	phosphorylation site [posttranslational modification]
568819001416	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
568819001417	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269
568819001418	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
568819001419	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
568819001420	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
568819001421	catalytic triad [active]
568819001422	Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807
568819001423	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819001424	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001425	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
568819001426	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
568819001427	Ligand Binding Site [chemical binding]; other site
568819001428	NUP50 (Nucleoporin 50 kDa); Region: NUP50; pfam08911
568819001429	Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843
568819001430	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
568819001431	putative active site [active]
568819001432	putative metal binding site [ion binding]; other site
568819001433	Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300
568819001434	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
568819001435	catalytic core [active]
568819001436	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
568819001437	Protein of unknown function (DUF1304); Region: DUF1304; cl01533
568819001438	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819001439	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568819001440	putative substrate translocation pore; other site
568819001441	iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702
568819001442	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819001443	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
568819001444	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
568819001445	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
568819001446	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
568819001447	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
568819001448	ATP binding site [chemical binding]; other site
568819001449	putative Mg++ binding site [ion binding]; other site
568819001450	Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008
568819001451	HsdM N-terminal domain; Region: HsdM_N; pfam12161
568819001452	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
568819001453	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
568819001454	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
568819001455	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
568819001456	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
568819001457	Phage integrase family; Region: Phage_integrase; pfam00589
568819001458	Int/Topo IB signature motif; other site
568819001459	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
568819001460	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
568819001461	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
568819001462	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
568819001463	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
568819001464	NAD binding site [chemical binding]; other site
568819001465	sugar binding site [chemical binding]; other site
568819001466	divalent metal binding site [ion binding]; other site
568819001467	tetramer (dimer of dimers) interface [polypeptide binding]; other site
568819001468	dimer interface [polypeptide binding]; other site
568819001469	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
568819001470	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013
568819001471	putative active site [active]
568819001472	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
568819001473	Sulfate transporter family; Region: Sulfate_transp; cl00967
568819001474	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
568819001475	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
568819001476	DNA binding residues [nucleotide binding]
568819001477	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
568819001478	dimer interface [polypeptide binding]; other site
568819001479	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
568819001480	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5298
568819001481	Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096
568819001482	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
568819001483	DXD motif; other site
568819001484	Bacterial cellulose synthase subunit; Region: BcsB; pfam03170
568819001485	cellulose synthase regulator protein; Provisional; Region: PRK11114
568819001486	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
568819001487	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
568819001488	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
568819001489	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
568819001490	Transcriptional regulators [Transcription]; Region: PurR; COG1609
568819001491	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568819001492	DNA binding site [nucleotide binding]
568819001493	domain linker motif; other site
568819001494	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
568819001495	putative dimerization interface [polypeptide binding]; other site
568819001496	putative ligand binding site [chemical binding]; other site
568819001497	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
568819001498	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
568819001499	NAD binding site [chemical binding]; other site
568819001500	sugar binding site [chemical binding]; other site
568819001501	divalent metal binding site [ion binding]; other site
568819001502	tetramer (dimer of dimers) interface [polypeptide binding]; other site
568819001503	dimer interface [polypeptide binding]; other site
568819001504	allantoate amidohydrolase; Reviewed; Region: PRK09290
568819001505	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
568819001506	active site
568819001507	metal binding site [ion binding]; metal-binding site
568819001508	dimer interface [polypeptide binding]; other site
568819001509	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
568819001510	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019
568819001511	metal binding site [ion binding]; metal-binding site
568819001512	putative dimer interface [polypeptide binding]; other site
568819001513	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
568819001514	Beta-lactamase; Region: Beta-lactamase; cl01009
568819001515	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262
568819001516	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
568819001517	intersubunit interface [polypeptide binding]; other site
568819001518	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516
568819001519	Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732
568819001520	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
568819001521	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
568819001522	PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515
568819001523	Glucitol operon activator protein (GutM); Region: GutM; cl01890
568819001524	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
568819001525	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819001526	SAF domain; Region: SAF; cl00555
568819001527	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
568819001528	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
568819001529	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568819001530	Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308
568819001531	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001532	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001533	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001534	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
568819001535	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
568819001536	FOG: CBS domain [General function prediction only]; Region: COG0517
568819001537	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cd02205
568819001538	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
568819001539	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
568819001540	dimer interface [polypeptide binding]; other site
568819001541	active site
568819001542	metal binding site [ion binding]; metal-binding site
568819001543	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
568819001544	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819001545	putative substrate translocation pore; other site
568819001546	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
568819001547	Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300
568819001548	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
568819001549	catalytic core [active]
568819001550	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
568819001551	Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300
568819001552	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
568819001553	catalytic core [active]
568819001554	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
568819001555	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
568819001556	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
568819001557	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
568819001558	glutamate dehydrogenase; Provisional; Region: PRK09414
568819001559	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
568819001560	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
568819001561	NAD(P) binding site [chemical binding]; other site
568819001562	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
568819001563	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
568819001564	Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107
568819001565	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731
568819001566	substrate binding site [chemical binding]; other site
568819001567	glutamase interaction surface [polypeptide binding]; other site
568819001568	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732
568819001569	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
568819001570	catalytic residues [active]
568819001571	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
568819001572	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
568819001573	putative active site [active]
568819001574	oxyanion strand; other site
568819001575	catalytic triad [active]
568819001576	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
568819001577	putative active site pocket [active]
568819001578	4-fold oligomerization interface [polypeptide binding]; other site
568819001579	metal binding residues [ion binding]; metal-binding site
568819001580	3-fold/trimer interface [polypeptide binding]; other site
568819001581	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
568819001582	E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572
568819001583	NAD binding site [chemical binding]; other site
568819001584	dimerization interface [polypeptide binding]; other site
568819001585	product binding site; other site
568819001586	substrate binding site [chemical binding]; other site
568819001587	zinc binding site [ion binding]; other site
568819001588	catalytic residues [active]
568819001589	ATP phosphoribosyltransferase; Region: HisG; cl15266
568819001590	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
568819001591	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
568819001592	dimer interface [polypeptide binding]; other site
568819001593	motif 1; other site
568819001594	active site
568819001595	motif 2; other site
568819001596	motif 3; other site
568819001597	histidinol-phosphatase; Reviewed; Region: PRK08123
568819001598	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
568819001599	DNA binding site [nucleotide binding]
568819001600	active site
568819001601	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
568819001602	Sulfate transporter family; Region: Sulfate_transp; cl00967
568819001603	Permease family; Region: Xan_ur_permease; pfam00860
568819001604	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
568819001605	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046
568819001606	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
568819001607	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819001608	DNA-binding site [nucleotide binding]; DNA binding site
568819001609	UTRA domain; Region: UTRA; cl01230
568819001610	MucBP domain; Region: MucBP; pfam06458
568819001611	Protein of unknown function (DUF1212); Region: DUF1212; cl01118
568819001612	Uncharacterized conserved protein [Function unknown]; Region: COG2966
568819001613	Protein of unknown function (DUF1212); Region: DUF1212; cl01118
568819001614	Protein of unknown function (DUF1212); Region: DUF1212; cl01118
568819001615	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; cl01839
568819001616	Predicted esterase [General function prediction only]; Region: COG0400
568819001617	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
568819001618	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
568819001619	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
568819001620	putative peptidoglycan binding site; other site
568819001621	SH3 domain protein [Signal transduction mechanisms]; Region: COG3103
568819001622	Bacterial SH3 domain; Region: SH3_3; cl02551
568819001623	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
568819001624	putative peptidoglycan binding site; other site
568819001625	NlpC/P60 family; Region: NLPC_P60; cl11438
568819001626	preprotein translocase subunit SecA; Reviewed; Region: PRK09200
568819001627	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
568819001628	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819001629	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
568819001630	Domain of unknown function DUF20; Region: UPF0118; cl00465
568819001631	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
568819001632	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
568819001633	UreD urease accessory protein; Region: UreD; cl00530
568819001634	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
568819001635	DNA photolyase; Region: DNA_photolyase; pfam00875
568819001636	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
568819001637	Predicted membrane protein (DUF2177); Region: DUF2177; cl02014
568819001638	DAK2 domain; Region: Dak2; cl03685
568819001639	Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577
568819001640	Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763
568819001641	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
568819001642	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
568819001643	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
568819001644	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
568819001645	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
568819001646	homodimer interface [polypeptide binding]; other site
568819001647	substrate-cofactor binding pocket; other site
568819001648	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819001649	catalytic residue [active]
568819001650	Uncharacterized conserved protein [Function unknown]; Region: HdeD; cl01277
568819001651	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
568819001652	ligand binding site [chemical binding]; other site
568819001653	flexible hinge region; other site
568819001654	BioY family; Region: BioY; cl00560
568819001655	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819001656	Protein of unknown function (DUF1700); Region: DUF1700; cl01933
568819001657	Uncharacterized conserved protein [Function unknown]; Region: COG3595
568819001658	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
568819001659	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
568819001660	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
568819001661	MatE; Region: MatE; cl10513
568819001662	MatE; Region: MatE; cl10513
568819001663	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819001664	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
568819001665	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
568819001666	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819001667	Walker A/P-loop; other site
568819001668	ATP binding site [chemical binding]; other site
568819001669	Q-loop/lid; other site
568819001670	ABC transporter signature motif; other site
568819001671	Walker B; other site
568819001672	D-loop; other site
568819001673	H-loop/switch region; other site
568819001674	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
568819001675	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
568819001676	Glucan exporter ATP-binding protein.  In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor.  This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254
568819001677	Walker A/P-loop; other site
568819001678	ATP binding site [chemical binding]; other site
568819001679	Q-loop/lid; other site
568819001680	ABC transporter signature motif; other site
568819001681	Walker B; other site
568819001682	D-loop; other site
568819001683	H-loop/switch region; other site
568819001684	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
568819001685	active site residue [active]
568819001686	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
568819001687	Transcriptional regulators [Transcription]; Region: MarR; COG1846
568819001688	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819001689	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
568819001690	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
568819001691	putative NAD(P) binding site [chemical binding]; other site
568819001692	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
568819001693	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
568819001694	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
568819001695	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
568819001696	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
568819001697	putative active site [active]
568819001698	catalytic site [active]
568819001699	putative metal binding site [ion binding]; other site
568819001700	Catalytic domain of Protein Kinases; Region: PKc; cd00180
568819001701	active site
568819001702	ATP binding site [chemical binding]; other site
568819001703	substrate binding site [chemical binding]; other site
568819001704	activation loop (A-loop); other site
568819001705	Protein of unknown function (DUF1398); Region: DUF1398; cl11576
568819001706	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
568819001707	Protein of unknown function (DUF3116); Region: DUF3116; pfam11313
568819001708	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
568819001709	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568819001710	Coenzyme A binding pocket [chemical binding]; other site
568819001711	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
568819001712	active site
568819001713	catalytic triad [active]
568819001714	oxyanion hole [active]
568819001715	Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619
568819001716	domain interaction interfaces; other site
568819001717	putative Ca2+ binding sites [ion binding]; other site
568819001718	putative ligand binding motif; other site
568819001719	Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cd00222
568819001720	domain interaction interfaces; other site
568819001721	putative Ca2+ binding sites [ion binding]; other site
568819001722	putative ligand binding motif; other site
568819001723	Isochorismatase family; Region: Isochorismatase; pfam00857
568819001724	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
568819001725	catalytic triad [active]
568819001726	conserved cis-peptide bond; other site
568819001727	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
568819001728	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
568819001729	motif II; other site
568819001730	Rrf2 family protein; Region: rrf2_super; TIGR00738
568819001731	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819001732	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
568819001733	S-adenosylmethionine binding site [chemical binding]; other site
568819001734	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
568819001735	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
568819001736	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
568819001737	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
568819001738	active site
568819001739	catalytic tetrad [active]
568819001740	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
568819001741	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
568819001742	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
568819001743	motif II; other site
568819001744	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
568819001745	catalytic residue [active]
568819001746	Sulfatase; Region: Sulfatase; cl10460
568819001747	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
568819001748	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
568819001749	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
568819001750	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
568819001751	putative metal binding site [ion binding]; other site
568819001752	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
568819001753	active site
568819001754	metal binding site [ion binding]; metal-binding site
568819001755	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
568819001756	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
568819001757	Transcriptional regulators [Transcription]; Region: GntR; COG1802
568819001758	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819001759	DNA-binding site [nucleotide binding]; DNA binding site
568819001760	Predicted membrane protein [Function unknown]; Region: COG1511
568819001761	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
568819001762	ABC-2 type transporter; Region: ABC2_membrane; cl11417
568819001763	Transcriptional regulators [Transcription]; Region: GntR; COG1802
568819001764	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819001765	DNA-binding site [nucleotide binding]; DNA binding site
568819001766	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
568819001767	Protein of unknown function (DUF975); Region: DUF975; cl10504
568819001768	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
568819001769	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
568819001770	active site
568819001771	metal binding site [ion binding]; metal-binding site
568819001772	Protein of unknown function (DUF420); Region: DUF420; cl00989
568819001773	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
568819001774	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
568819001775	cofactor binding site; other site
568819001776	DNA binding site [nucleotide binding]
568819001777	substrate interaction site [chemical binding]; other site
568819001778	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
568819001779	Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326
568819001780	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568819001781	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819001782	ATP binding site [chemical binding]; other site
568819001783	Mg2+ binding site [ion binding]; other site
568819001784	G-X-G motif; other site
568819001785	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
568819001786	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
568819001787	minor groove reading motif; other site
568819001788	helix-hairpin-helix signature motif; other site
568819001789	substrate binding pocket [chemical binding]; other site
568819001790	active site
568819001791	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
568819001792	C-terminal domain; Region: RGG_Cterm; TIGR01716
568819001793	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
568819001794	MucBP domain; Region: MucBP; pfam06458
568819001795	MucBP domain; Region: MucBP; pfam06458
568819001796	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
568819001797	bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427
568819001798	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
568819001799	dimer interface [polypeptide binding]; other site
568819001800	substrate binding site [chemical binding]; other site
568819001801	ATP binding site [chemical binding]; other site
568819001802	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
568819001803	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
568819001804	active site
568819001805	motif I; other site
568819001806	motif II; other site
568819001807	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
568819001808	maltose O-acetyltransferase; Provisional; Region: PRK10092
568819001809	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
568819001810	active site
568819001811	substrate binding site [chemical binding]; other site
568819001812	trimer interface [polypeptide binding]; other site
568819001813	CoA binding site [chemical binding]; other site
568819001814	Protein of unknown function (DUF423); Region: DUF423; cl01008
568819001815	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
568819001816	The ABCA subfamily mediates the transport of a variety of lipid compounds.  Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency...; Region: ABC_subfamily_A; cd03263
568819001817	Walker A/P-loop; other site
568819001818	ATP binding site [chemical binding]; other site
568819001819	Q-loop/lid; other site
568819001820	ABC transporter signature motif; other site
568819001821	Walker B; other site
568819001822	D-loop; other site
568819001823	H-loop/switch region; other site
568819001824	ABC-2 type transporter; Region: ABC2_membrane; cl11417
568819001825	oxidoreductase; Provisional; Region: PRK07985
568819001826	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819001827	NAD(P) binding site [chemical binding]; other site
568819001828	active site
568819001829	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; cl11557
568819001830	Protein of unknown function (DUF805); Region: DUF805; cl01224
568819001831	DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181
568819001832	FliP family; Region: FliP; cl00593
568819001833	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
568819001834	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
568819001835	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
568819001836	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017
568819001837	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
568819001838	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
568819001839	flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12726
568819001840	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
568819001841	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819
568819001842	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
568819001843	Domain of unknown function (DUF1078); Region: DUF1078; pfam06429
568819001844	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
568819001845	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
568819001846	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
568819001847	flagellar motor protein MotA; Validated; Region: PRK08124
568819001848	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
568819001849	flagellar motor protein MotB; Reviewed; Region: motB; PRK07734
568819001850	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
568819001851	ligand binding site [chemical binding]; other site
568819001852	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
568819001853	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
568819001854	putative metal binding site [ion binding]; other site
568819001855	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
568819001856	binding surface
568819001857	TPR motif; other site
568819001858	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
568819001859	Response regulator receiver domain; Region: Response_reg; pfam00072
568819001860	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
568819001861	active site
568819001862	phosphorylation site [posttranslational modification]
568819001863	intermolecular recognition site; other site
568819001864	dimerization interface [polypeptide binding]; other site
568819001865	flagellin; Provisional; Region: PRK12805
568819001866	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
568819001867	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
568819001868	Response regulator receiver domain; Region: Response_reg; pfam00072
568819001869	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
568819001870	active site
568819001871	phosphorylation site [posttranslational modification]
568819001872	intermolecular recognition site; other site
568819001873	dimerization interface [polypeptide binding]; other site
568819001874	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
568819001875	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
568819001876	putative binding surface; other site
568819001877	active site
568819001878	P2 response regulator binding domain; Region: P2; pfam07194
568819001879	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
568819001880	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819001881	ATP binding site [chemical binding]; other site
568819001882	Mg2+ binding site [ion binding]; other site
568819001883	G-X-G motif; other site
568819001884	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
568819001885	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
568819001886	ribonuclease E; Reviewed; Region: rne; PRK10811
568819001887	Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269
568819001888	Flagellar hook capping protein; Region: FlgD; cl04347
568819001889	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
568819001890	Flagella basal body rod protein; Region: Flg_bb_rod; cl15245
568819001891	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
568819001892	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
568819001893	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
568819001894	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
568819001895	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
568819001896	flagellar motor switch protein; Reviewed; Region: PRK06782
568819001897	CheC-like family; Region: CheC; pfam04509
568819001898	CheC-like family; Region: CheC; pfam04509
568819001899	CheC-like family; Region: CheC; pfam04509
568819001900	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
568819001901	Protein of unknown function (DUF327); Region: DUF327; cl00753
568819001902	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799
568819001903	Domain of unknown function (DUF1078); Region: DUF1078; pfam06429
568819001904	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073
568819001905	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
568819001906	flagellar capping protein; Validated; Region: fliD; PRK06798
568819001907	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
568819001908	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
568819001909	Flagellar protein FliS; Region: FliS; cl00654
568819001910	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797
568819001911	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558
568819001912	Domain of unknown function (DUF1078); Region: DUF1078; pfam06429
568819001913	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
568819001914	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
568819001915	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
568819001916	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
568819001917	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
568819001918	FliG C-terminal domain; Region: FliG_C; pfam01706
568819001919	flagellar assembly protein H; Validated; Region: fliH; PRK06800
568819001920	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793
568819001921	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819001922	Walker A motif; other site
568819001923	ATP binding site [chemical binding]; other site
568819001924	Walker B motif; other site
568819001925	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
568819001926	N-acetyl-D-glucosamine binding site [chemical binding]; other site
568819001927	catalytic residue [active]
568819001928	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819001929	Protein of unknown function (DUF1048); Region: DUF1048; cl01986
568819001930	Fibronectin-binding protein (FBP); Region: FBP; pfam07299
568819001931	pyruvate oxidase; Provisional; Region: PRK08611
568819001932	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
568819001933	PYR/PP interface [polypeptide binding]; other site
568819001934	tetramer interface [polypeptide binding]; other site
568819001935	dimer interface [polypeptide binding]; other site
568819001936	TPP binding site [chemical binding]; other site
568819001937	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
568819001938	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX...; Region: TPP_POX; cd02014
568819001939	TPP-binding site [chemical binding]; other site
568819001940	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729
568819001941	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
568819001942	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
568819001943	dimerization interface [polypeptide binding]; other site
568819001944	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
568819001945	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
568819001946	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
568819001947	putative active site [active]
568819001948	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
568819001949	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714
568819001950	glutaminase active site [active]
568819001951	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
568819001952	dimer interface [polypeptide binding]; other site
568819001953	active site
568819001954	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
568819001955	dimer interface [polypeptide binding]; other site
568819001956	active site
568819001957	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
568819001958	active site
568819001959	GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451
568819001960	GIY-YIG motif/motif A; other site
568819001961	leucine-rich repeat receptor-like protein kinase; Provisional; Region: PLN00113
568819001962	MucBP domain; Region: MucBP; pfam06458
568819001963	MucBP domain; Region: MucBP; pfam06458
568819001964	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568819001965	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568819001966	non-specific DNA binding site [nucleotide binding]; other site
568819001967	salt bridge; other site
568819001968	sequence-specific DNA binding site [nucleotide binding]; other site
568819001970	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
568819001971	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819001972	DNA-binding site [nucleotide binding]; DNA binding site
568819001973	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
568819001974	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
568819001975	Walker A/P-loop; other site
568819001976	ATP binding site [chemical binding]; other site
568819001977	Q-loop/lid; other site
568819001978	ABC transporter signature motif; other site
568819001979	Walker B; other site
568819001980	D-loop; other site
568819001981	H-loop/switch region; other site
568819001982	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
568819001983	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
568819001984	Walker A/P-loop; other site
568819001985	ATP binding site [chemical binding]; other site
568819001986	Q-loop/lid; other site
568819001987	ABC transporter signature motif; other site
568819001988	Walker B; other site
568819001989	D-loop; other site
568819001990	H-loop/switch region; other site
568819001991	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
568819001992	FtsX-like permease family; Region: FtsX; pfam02687
568819001993	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
568819001994	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568819001995	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
568819001996	ligand binding site [chemical binding]; other site
568819001997	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819001998	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
568819001999	active site
568819002000	catalytic triad [active]
568819002001	oxyanion hole [active]
568819002002	The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance.  Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis.  The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268
568819002003	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
568819002004	Walker A/P-loop; other site
568819002005	ATP binding site [chemical binding]; other site
568819002006	Q-loop/lid; other site
568819002007	ABC transporter signature motif; other site
568819002008	Walker B; other site
568819002009	D-loop; other site
568819002010	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819002011	H-loop/switch region; other site
568819002012	active site
568819002013	ABC-2 type transporter; Region: ABC2_membrane; cl11417
568819002014	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
568819002015	Zn binding site [ion binding]; other site
568819002016	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
568819002017	Zn binding site [ion binding]; other site
568819002018	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
568819002019	Zn binding site [ion binding]; other site
568819002020	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
568819002021	Zn binding site [ion binding]; other site
568819002022	Predicted esterase [General function prediction only]; Region: COG0400
568819002023	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
568819002024	Flavin Reductases; Region: FlaRed; cl00801
568819002025	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
568819002026	HflX subfamily.  A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily.  The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878
568819002027	G1 box; other site
568819002028	GTP/Mg2+ binding site [chemical binding]; other site
568819002029	Switch I region; other site
568819002030	G2 box; other site
568819002031	G3 box; other site
568819002032	Switch II region; other site
568819002033	G4 box; other site
568819002034	G5 box; other site
568819002035	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
568819002036	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
568819002037	putative active site [active]
568819002038	putative metal binding site [ion binding]; other site
568819002039	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
568819002040	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
568819002041	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
568819002042	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
568819002043	Uncharacterized conserved protein [Function unknown]; Region: COG3538
568819002044	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
568819002045	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
568819002046	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819002047	putative PBP binding loops; other site
568819002048	ABC-ATPase subunit interface; other site
568819002049	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
568819002050	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819002051	dimer interface [polypeptide binding]; other site
568819002052	conserved gate region; other site
568819002053	putative PBP binding loops; other site
568819002054	ABC-ATPase subunit interface; other site
568819002055	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
568819002056	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
568819002057	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996
568819002058	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819002059	DNA-binding site [nucleotide binding]; DNA binding site
568819002060	Transcriptional regulators [Transcription]; Region: PurR; COG1609
568819002061	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
568819002062	ligand binding site [chemical binding]; other site
568819002063	dimerization interface [polypeptide binding]; other site
568819002064	Transcriptional regulators [Transcription]; Region: GntR; COG1802
568819002065	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819002066	DNA-binding site [nucleotide binding]; DNA binding site
568819002067	Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289
568819002068	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
568819002069	putative NADP binding site [chemical binding]; other site
568819002070	putative dimer interface [polypeptide binding]; other site
568819002071	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
568819002072	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
568819002073	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
568819002074	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
568819002075	Protein of unknown function (DUF986); Region: DUF986; cl01983
568819002076	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
568819002077	PTS system sorbose-specific iic component; Region: EII-Sor; cl01506
568819002078	Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four...; Region: PTS_IIB_man; cd00001
568819002079	active site
568819002080	phosphorylation site [posttranslational modification]
568819002081	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006
568819002082	active pocket/dimerization site; other site
568819002083	active site
568819002084	phosphorylation site [posttranslational modification]
568819002085	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
568819002086	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
568819002087	Walker A motif; other site
568819002088	ATP binding site [chemical binding]; other site
568819002089	Walker B motif; other site
568819002090	arginine finger; other site
568819002091	Transcriptional antiterminator [Transcription]; Region: COG3933
568819002092	PRD domain; Region: PRD; pfam00874
568819002093	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006
568819002094	active pocket/dimerization site; other site
568819002095	active site
568819002096	phosphorylation site [posttranslational modification]
568819002097	PRD domain; Region: PRD; pfam00874
568819002098	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
568819002099	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
568819002100	Amino acid permease; Region: AA_permease; pfam00324
568819002101	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
568819002102	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
568819002103	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
568819002104	CoA enzyme activase uncharacterised domain (DUF2229); Region: DUF2229; cl12083
568819002105	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
568819002106	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
568819002107	MucBP domain; Region: MucBP; pfam06458
568819002108	MucBP domain; Region: MucBP; pfam06458
568819002109	MucBP domain; Region: MucBP; pfam06458
568819002110	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
568819002111	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
568819002112	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS); Region: YbaK_deacylase; cd00002
568819002113	putative deacylase active site [active]
568819002114	Predicted amidohydrolase [General function prediction only]; Region: COG0388
568819002115	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
568819002116	active site
568819002117	catalytic triad [active]
568819002118	dimer interface [polypeptide binding]; other site
568819002119	Protein of unknown function (DUF554); Region: DUF554; cl00784
568819002120	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
568819002121	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
568819002122	NAD binding site [chemical binding]; other site
568819002123	substrate binding site [chemical binding]; other site
568819002124	putative active site [active]
568819002125	Predicted permeases [General function prediction only]; Region: RarD; COG2962
568819002126	EamA-like transporter family; Region: EamA; cl01037
568819002127	YceI-like domain; Region: YceI; cl01001
568819002128	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819002129	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
568819002130	Amino acid permease; Region: AA_permease; pfam00324
568819002131	PAS domain S-box; Region: sensory_box; TIGR00229
568819002132	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
568819002133	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
568819002134	Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
568819002135	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918
568819002136	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
568819002137	synthetase active site [active]
568819002138	NTP binding site [chemical binding]; other site
568819002139	metal binding site [ion binding]; metal-binding site
568819002140	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
568819002141	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
568819002142	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568819002143	non-specific DNA binding site [nucleotide binding]; other site
568819002144	salt bridge; other site
568819002145	sequence-specific DNA binding site [nucleotide binding]; other site
568819002146	Cupin domain; Region: Cupin_2; cl09118
568819002147	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
568819002148	PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D.  PotA has two domains with the N-terminal domain containing the ATPase activity and the residues...; Region: ABC_PotA_N; cd03300
568819002149	Walker A/P-loop; other site
568819002150	ATP binding site [chemical binding]; other site
568819002151	Q-loop/lid; other site
568819002152	ABC transporter signature motif; other site
568819002153	Walker B; other site
568819002154	D-loop; other site
568819002155	H-loop/switch region; other site
568819002156	TOBE domain; Region: TOBE_2; cl01440
568819002157	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819002158	dimer interface [polypeptide binding]; other site
568819002159	conserved gate region; other site
568819002160	putative PBP binding loops; other site
568819002161	ABC-ATPase subunit interface; other site
568819002162	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
568819002163	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819002164	dimer interface [polypeptide binding]; other site
568819002165	conserved gate region; other site
568819002166	putative PBP binding loops; other site
568819002167	ABC-ATPase subunit interface; other site
568819002168	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
568819002169	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
568819002170	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
568819002171	active site
568819002172	zinc binding site [ion binding]; other site
568819002173	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
568819002174	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
568819002175	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
568819002176	putative enoyl-(acyl-carrier-protein) reductase II; Region: enACPred_II; TIGR03151
568819002177	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730
568819002178	FMN binding site [chemical binding]; other site
568819002179	substrate binding site [chemical binding]; other site
568819002180	putative catalytic residue [active]
568819002181	Protein of unknown function (DUF3130; Region: DUF3130; pfam11328
568819002182	Bacillus transposase protein; Region: Transposase_30; pfam04740
568819002183	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
568819002184	dimer interface [polypeptide binding]; other site
568819002185	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
568819002186	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
568819002187	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
568819002188	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
568819002189	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
568819002190	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
568819002191	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
568819002192	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
568819002193	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
568819002194	DNA binding residues [nucleotide binding]
568819002195	putative dimer interface [polypeptide binding]; other site
568819002196	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
568819002197	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
568819002198	active site
568819002199	catalytic tetrad [active]
568819002200	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
568819002201	homodimer interface [polypeptide binding]; other site
568819002202	3-hydroxy-3-methylglutaryl Coenzyme A reductase, hydroxymethylglutaryl-CoA reductase (NADP); Region: HMG_CoA_R_NADP; TIGR00533
568819002203	NAD binding site [chemical binding]; other site
568819002204	catalytic residues [active]
568819002205	substrate binding pocket [chemical binding]; other site
568819002206	flexible flap; other site
568819002207	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
568819002208	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
568819002209	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
568819002210	PhoU domain; Region: PhoU; pfam01895
568819002211	PhoU domain; Region: PhoU; pfam01895
568819002212	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
568819002213	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
568819002214	dimer interface [polypeptide binding]; other site
568819002215	PYR/PP interface [polypeptide binding]; other site
568819002216	TPP binding site [chemical binding]; other site
568819002217	substrate binding site [chemical binding]; other site
568819002218	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
568819002219	Domain of unknown function; Region: EKR; cl11037
568819002220	4Fe-4S binding domain; Region: Fer4; cl02805
568819002221	TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This subfamily also includes proteins characterized as...; Region: TPP_PFOR_PNO; cd03377
568819002222	TPP-binding site [chemical binding]; other site
568819002223	dimer interface [polypeptide binding]; other site
568819002224	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
568819002225	Membrane transport protein; Region: Mem_trans; cl09117
568819002226	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
568819002227	C-terminal domain; Region: RGG_Cterm; TIGR01716
568819002228	Phosphate-starvation-inducible E; Region: PsiE; cl01264
568819002229	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
568819002230	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
568819002231	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
568819002232	Walker A/P-loop; other site
568819002233	ATP binding site [chemical binding]; other site
568819002234	Q-loop/lid; other site
568819002235	ABC transporter signature motif; other site
568819002236	Walker B; other site
568819002237	D-loop; other site
568819002238	H-loop/switch region; other site
568819002239	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
568819002240	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819002241	putative substrate translocation pore; other site
568819002242	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819002243	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819002244	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568819002245	putative substrate translocation pore; other site
568819002246	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819002247	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
568819002248	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
568819002249	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
568819002250	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
568819002251	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
568819002252	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568819002253	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568819002254	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568819002255	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568819002256	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568819002257	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568819002258	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568819002259	Protein of unknown function (DUF1294); Region: DUF1294; cl01311
568819002260	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
568819002261	homotrimer interaction site [polypeptide binding]; other site
568819002262	putative active site [active]
568819002263	C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311
568819002264	substrate binding site [chemical binding]; other site
568819002265	zinc-binding site [ion binding]; other site
568819002266	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
568819002267	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
568819002268	GIY-YIG motif/motif A; other site
568819002269	active site
568819002270	catalytic site [active]
568819002271	putative DNA binding site [nucleotide binding]; other site
568819002272	metal binding site [ion binding]; metal-binding site
568819002273	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
568819002274	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
568819002275	substrate binding pocket [chemical binding]; other site
568819002276	membrane-bound complex binding site; other site
568819002277	hinge residues; other site
568819002278	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
568819002279	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819002280	dimer interface [polypeptide binding]; other site
568819002281	conserved gate region; other site
568819002282	putative PBP binding loops; other site
568819002283	ABC-ATPase subunit interface; other site
568819002284	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
568819002285	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262
568819002286	Walker A/P-loop; other site
568819002287	ATP binding site [chemical binding]; other site
568819002288	Q-loop/lid; other site
568819002289	ABC transporter signature motif; other site
568819002290	Walker B; other site
568819002291	D-loop; other site
568819002292	H-loop/switch region; other site
568819002293	amidase; Provisional; Region: PRK11910
568819002294	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
568819002295	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568819002296	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568819002297	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
568819002298	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
568819002299	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
568819002300	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
568819002301	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
568819002302	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
568819002303	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
568819002304	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
568819002305	Esterase/lipase [General function prediction only]; Region: COG1647
568819002306	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892
568819002307	Transcriptional regulators [Transcription]; Region: PurR; COG1609
568819002308	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568819002309	DNA binding site [nucleotide binding]
568819002310	domain linker motif; other site
568819002311	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277
568819002312	putative dimerization interface [polypeptide binding]; other site
568819002313	putative ligand binding site [chemical binding]; other site
568819002314	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
568819002315	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
568819002316	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
568819002317	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819002318	dimer interface [polypeptide binding]; other site
568819002319	conserved gate region; other site
568819002320	putative PBP binding loops; other site
568819002321	ABC-ATPase subunit interface; other site
568819002322	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819002323	dimer interface [polypeptide binding]; other site
568819002324	conserved gate region; other site
568819002325	ABC-ATPase subunit interface; other site
568819002326	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
568819002327	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
568819002328	Protein of unknown function (DUF1861); Region: DUF1861; pfam08950
568819002329	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
568819002330	active site
568819002331	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799
568819002332	active site
568819002333	substrate binding site [chemical binding]; other site
568819002334	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
568819002335	metal binding site [ion binding]; metal-binding site
568819002336	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif (...; Region: DEADc; cd00268
568819002337	DEAD-like helicases superfamily; Region: DEXDc; smart00487
568819002338	ATP binding site [chemical binding]; other site
568819002339	Mg++ binding site [ion binding]; other site
568819002340	motif III; other site
568819002341	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568819002342	nucleotide binding region [chemical binding]; other site
568819002343	Hef nuclease; Provisional; Region: PRK13766
568819002344	ATP-binding site [chemical binding]; other site
568819002345	QueT transporter; Region: QueT; cl01932
568819002346	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
568819002347	Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805
568819002348	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819002349	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
568819002350	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819002351	putative substrate translocation pore; other site
568819002352	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
568819002353	PRD domain; Region: PRD; pfam00874
568819002354	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
568819002355	P-loop; other site
568819002356	active site
568819002357	phosphorylation site [posttranslational modification]
568819002358	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819002359	active site
568819002360	phosphorylation site [posttranslational modification]
568819002361	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
568819002362	methionine cluster; other site
568819002363	active site
568819002364	phosphorylation site [posttranslational modification]
568819002365	metal binding site [ion binding]; metal-binding site
568819002366	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564
568819002367	active site
568819002368	P-loop; other site
568819002369	phosphorylation site [posttranslational modification]
568819002370	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
568819002371	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination...; Region: GlcN6P_deaminase; cd01399
568819002372	active site
568819002373	trimer interface [polypeptide binding]; other site
568819002374	allosteric site; other site
568819002375	active site lid [active]
568819002376	hexamer (dimer of trimers) interface [polypeptide binding]; other site
568819002377	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
568819002378	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
568819002379	active site
568819002380	catalytic tetrad [active]
568819002381	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
568819002382	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
568819002383	Collagen binding domain; Region: Collagen_bind; pfam05737
568819002384	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
568819002385	putative peptidoglycan binding site; other site
568819002386	Bacterial membrane flanked domain; Region: DUF304; cl01348
568819002387	Predicted membrane protein [Function unknown]; Region: COG3428
568819002388	Bacterial membrane flanked domain; Region: DUF304; cl01348
568819002389	Bacterial membrane flanked domain; Region: DUF304; cl01348
568819002390	Bacterial membrane flanked domain; Region: DUF304; cl01348
568819002391	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819002392	Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232
568819002393	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
568819002394	alanine racemase; Reviewed; Region: alr; PRK00053
568819002395	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
568819002396	active site
568819002397	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
568819002398	dimer interface [polypeptide binding]; other site
568819002399	substrate binding site [chemical binding]; other site
568819002400	catalytic residues [active]
568819002401	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
568819002402	PemK-like protein; Region: PemK; cl00995
568819002403	Rsbr N terminal; Region: Rsbr_N; pfam08678
568819002404	Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
568819002405	Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
568819002406	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
568819002407	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
568819002408	Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673
568819002409	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
568819002410	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
568819002411	anti sigma factor interaction site; other site
568819002412	regulatory phosphorylation site [posttranslational modification]; other site
568819002413	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819002414	ATP binding site [chemical binding]; other site
568819002415	Mg2+ binding site [ion binding]; other site
568819002416	G-X-G motif; other site
568819002417	RNA polymerase sigma factor SigB; Validated; Region: PRK08583
568819002418	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
568819002419	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
568819002420	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
568819002421	DNA binding residues [nucleotide binding]
568819002422	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
568819002423	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
568819002424	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
568819002425	Sulfate transporter family; Region: Sulfate_transp; cl00967
568819002426	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
568819002427	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
568819002428	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
568819002429	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
568819002430	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685
568819002431	RNA binding site [nucleotide binding]; other site
568819002432	hypothetical protein; Provisional; Region: PRK04351
568819002433	SprT homologues; Region: SprT; cl01182
568819002434	Domain of unknown function (DUF1768); Region: DUF1768; cl01271
568819002435	SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747
568819002436	Protein of unknown function (DUF419); Region: DUF419; cl15265
568819002437	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
568819002438	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
568819002439	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819002440	DNA-binding site [nucleotide binding]; DNA binding site
568819002441	UTRA domain; Region: UTRA; cl01230
568819002444	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053
568819002445	glutathione reductase; Validated; Region: PRK06116
568819002446	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819002447	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
568819002448	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
568819002449	Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300
568819002450	catalytic core [active]
568819002451	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
568819002452	Domain of unknown function DUF20; Region: UPF0118; cl00465
568819002453	Predicted transcriptional regulators [Transcription]; Region: COG1725
568819002454	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819002455	DNA-binding site [nucleotide binding]; DNA binding site
568819002456	Protein of unknown function (DUF1648); Region: DUF1648; cl01712
568819002457	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368
568819002458	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
568819002459	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
568819002460	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
568819002461	tetramerization interface [polypeptide binding]; other site
568819002462	NAD(P) binding site [chemical binding]; other site
568819002463	catalytic residues [active]
568819002464	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
568819002465	P-loop; other site
568819002466	active site
568819002467	phosphorylation site [posttranslational modification]
568819002468	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
568819002469	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
568819002470	methionine cluster; other site
568819002471	active site
568819002472	phosphorylation site [posttranslational modification]
568819002473	metal binding site [ion binding]; metal-binding site
568819002474	6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593
568819002475	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046
568819002476	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
568819002477	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819002478	PRD domain; Region: PRD; pfam00874
568819002479	PRD domain; Region: PRD; pfam00874
568819002480	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819002481	active site
568819002482	phosphorylation site [posttranslational modification]
568819002483	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
568819002484	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
568819002485	ABC transporter; Region: ABC_tran_2; pfam12848
568819002486	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
568819002487	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
568819002488	Predicted permease; Region: DUF318; cl00487
568819002489	Domain of unknown function (DUF1980); Region: DUF1980; cl01492
568819002490	pantothenate kinase; Provisional; Region: PRK05439
568819002491	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025
568819002492	ATP-binding site [chemical binding]; other site
568819002493	CoA-binding site [chemical binding]; other site
568819002494	Mg2+-binding site [ion binding]; other site
568819002495	PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
568819002496	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819002497	Walker A/P-loop; other site
568819002498	ATP binding site [chemical binding]; other site
568819002499	Q-loop/lid; other site
568819002500	ABC transporter signature motif; other site
568819002501	Walker B; other site
568819002502	D-loop; other site
568819002503	H-loop/switch region; other site
568819002504	ABC-2 type transporter; Region: ABC2_membrane; cl11417
568819002505	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568819002506	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568819002507	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
568819002508	Domain of unknown function (DUF373); Region: DUF373; cl12079
568819002509	Sulfatase; Region: Sulfatase; cl10460
568819002510	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
568819002511	active site
568819002512	DNA binding site [nucleotide binding]
568819002513	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
568819002514	active site
568819002515	catalytic site [active]
568819002516	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
568819002517	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
568819002518	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
568819002519	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
568819002520	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
568819002521	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961
568819002522	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
568819002523	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
568819002524	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
568819002525	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
568819002526	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH...; Region: NfsA_FRP; cd02146
568819002527	dimer interface [polypeptide binding]; other site
568819002528	FMN binding site [chemical binding]; other site
568819002529	NADPH bind site [chemical binding]; other site
568819002530	Low molecular weight phosphatase family; Region: LMWPc; cd00115
568819002531	Active site [active]
568819002532	SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747
568819002533	HSP90 family protein; Provisional; Region: PRK14083
568819002534	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819002535	ATP binding site [chemical binding]; other site
568819002536	Mg2+ binding site [ion binding]; other site
568819002537	G-X-G motif; other site
568819002538	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
568819002539	Ferritin-like domain; Region: Ferritin; pfam00210
568819002540	dimerization interface [polypeptide binding]; other site
568819002541	DPS ferroxidase diiron center [ion binding]; other site
568819002542	ion pore; other site
568819002543	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
568819002544	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
568819002545	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
568819002546	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
568819002547	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
568819002548	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819002549	putative substrate translocation pore; other site
568819002550	Transcriptional regulators [Transcription]; Region: FadR; COG2186
568819002551	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819002552	DNA-binding site [nucleotide binding]; DNA binding site
568819002553	FCD domain; Region: FCD; cl11656
568819002554	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
568819002555	Domain of unknown function DUF20; Region: UPF0118; cl00465
568819002556	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892
568819002557	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892
568819002558	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
568819002559	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
568819002560	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
568819002561	active site
568819002562	dimer interface [polypeptide binding]; other site
568819002563	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination...; Region: GlcN6P_deaminase; cd01399
568819002564	active site
568819002565	trimer interface [polypeptide binding]; other site
568819002566	allosteric site; other site
568819002567	active site lid [active]
568819002568	hexamer (dimer of trimers) interface [polypeptide binding]; other site
568819002569	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
568819002570	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819002571	DNA-binding site [nucleotide binding]; DNA binding site
568819002572	UTRA domain; Region: UTRA; cl01230
568819002573	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
568819002574	Mg++ binding site [ion binding]; other site
568819002575	putative catalytic motif [active]
568819002576	substrate binding site [chemical binding]; other site
568819002577	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259
568819002578	Peptidase family U32; Region: Peptidase_U32; cl03113
568819002579	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
568819002580	Peptidase family U32; Region: Peptidase_U32; cl03113
568819002581	LemA family; Region: LemA; cl00742
568819002582	Peptidase family M48; Region: Peptidase_M48; cl12018
568819002583	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
568819002584	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
568819002585	catalytic residues [active]
568819002586	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
568819002587	putative active site [active]
568819002588	putative metal binding residues [ion binding]; other site
568819002589	signature motif; other site
568819002590	putative triphosphate binding site [ion binding]; other site
568819002591	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
568819002592	TPR motif; other site
568819002593	binding surface
568819002594	Tetratrico peptide repeat; Region: TPR_5; pfam12688
568819002595	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
568819002596	synthetase active site [active]
568819002597	NTP binding site [chemical binding]; other site
568819002598	metal binding site [ion binding]; metal-binding site
568819002599	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
568819002600	ATP-NAD kinase; Region: NAD_kinase; pfam01513
568819002601	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
568819002602	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
568819002603	active site
568819002604	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
568819002605	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
568819002606	NAD binding site [chemical binding]; other site
568819002607	homotetramer interface [polypeptide binding]; other site
568819002608	homodimer interface [polypeptide binding]; other site
568819002609	substrate binding site [chemical binding]; other site
568819002610	active site
568819002611	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
568819002612	DltD N-terminal region; Region: DltD_N; pfam04915
568819002613	DltD central region; Region: DltD_M; pfam04918
568819002614	DltD C-terminal region; Region: DltD_C; pfam04914
568819002615	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087; cl07963
568819002616	MBOAT family; Region: MBOAT; cl00738
568819002617	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
568819002618	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
568819002619	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
568819002620	tetramer (dimer of dimers) interface [polypeptide binding]; other site
568819002621	active site
568819002622	dimer interface [polypeptide binding]; other site
568819002623	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
568819002624	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
568819002625	Putative esterase; Region: Esterase; pfam00756
568819002626	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
568819002627	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557
568819002628	homodimer interface [polypeptide binding]; other site
568819002629	substrate-cofactor binding pocket; other site
568819002630	catalytic residue [active]
568819002631	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
568819002632	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819002633	Walker A/P-loop; other site
568819002634	ATP binding site [chemical binding]; other site
568819002635	Q-loop/lid; other site
568819002636	ABC transporter signature motif; other site
568819002637	Walker B; other site
568819002638	D-loop; other site
568819002639	H-loop/switch region; other site
568819002640	ABC-2 type transporter; Region: ABC2_membrane; cl11417
568819002641	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819002642	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568819002643	putative substrate translocation pore; other site
568819002644	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
568819002645	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
568819002646	putative oligomer interface [polypeptide binding]; other site
568819002647	putative active site [active]
568819002648	metal binding site [ion binding]; metal-binding site
568819002649	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340
568819002650	catalytic residues [active]
568819002651	dimer interface [polypeptide binding]; other site
568819002652	LytTr DNA-binding domain; Region: LytTR; cl04498
568819002653	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
568819002654	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819002655	Walker A/P-loop; other site
568819002656	ATP binding site [chemical binding]; other site
568819002657	Q-loop/lid; other site
568819002658	ABC transporter signature motif; other site
568819002659	Walker B; other site
568819002660	D-loop; other site
568819002661	H-loop/switch region; other site
568819002662	ABC-2 type transporter; Region: ABC2_membrane; cl11417
568819002663	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
568819002664	RF3 subfamily.  Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria.  Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169
568819002665	G1 box; other site
568819002666	putative GEF interaction site [polypeptide binding]; other site
568819002667	GTP/Mg2+ binding site [chemical binding]; other site
568819002668	Switch I region; other site
568819002669	G2 box; other site
568819002670	G3 box; other site
568819002671	Switch II region; other site
568819002672	G4 box; other site
568819002673	G5 box; other site
568819002674	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
568819002675	Transcriptional regulators [Transcription]; Region: MarR; COG1846
568819002676	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819002677	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
568819002678	MatE; Region: MatE; cl10513
568819002679	Integral membrane protein TerC family; Region: TerC; cl10468
568819002680	Integral membrane protein TerC family; Region: TerC; cl10468
568819002681	Cation transport protein; Region: TrkH; cl10514
568819002682	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
568819002683	Cation transport protein; Region: TrkH; cl10514
568819002684	Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792
568819002685	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
568819002686	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
568819002687	DNA binding site [nucleotide binding]
568819002688	active site
568819002689	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
568819002690	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
568819002691	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
568819002692	Walker A motif; other site
568819002693	ATP binding site [chemical binding]; other site
568819002694	Walker B motif; other site
568819002695	arginine finger; other site
568819002696	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
568819002697	UvrB/uvrC motif; Region: UVR; pfam02151
568819002698	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
568819002699	Walker A motif; other site
568819002700	ATP binding site [chemical binding]; other site
568819002701	Walker B motif; other site
568819002702	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
568819002703	CAAX amino terminal protease self- immunity; Region: Abi; cl00558
568819002704	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
568819002705	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819002706	Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556
568819002707	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
568819002708	dimerization domain swap beta strand [polypeptide binding]; other site
568819002709	regulatory protein interface [polypeptide binding]; other site
568819002710	active site
568819002711	regulatory phosphorylation site [posttranslational modification]; other site
568819002712	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
568819002713	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
568819002714	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
568819002715	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
568819002716	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
568819002717	putative active site [active]
568819002718	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
568819002719	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819002720	hypothetical protein; Validated; Region: PRK07682
568819002721	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
568819002722	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819002723	homodimer interface [polypeptide binding]; other site
568819002724	catalytic residue [active]
568819002725	Protein of unknown function (DUF1797); Region: DUF1797; cl11550
568819002726	FOG: CBS domain [General function prediction only]; Region: COG0517
568819002727	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_30; cd04643
568819002728	Transcriptional regulator [Transcription]; Region: LysR; COG0583
568819002729	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819002730	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
568819002731	dimerization interface [polypeptide binding]; other site
568819002732	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapD_N; pfam08503
568819002733	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
568819002734	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
568819002735	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
568819002736	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
568819002737	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
568819002738	metal binding site [ion binding]; metal-binding site
568819002739	putative dimer interface [polypeptide binding]; other site
568819002740	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
568819002741	Mechanosensitive ion channel; Region: MS_channel; pfam00924
568819002742	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
568819002743	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819002744	Walker A/P-loop; other site
568819002745	ATP binding site [chemical binding]; other site
568819002746	Q-loop/lid; other site
568819002747	ABC transporter signature motif; other site
568819002748	Walker B; other site
568819002749	D-loop; other site
568819002750	H-loop/switch region; other site
568819002751	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141
568819002752	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819002753	dimer interface [polypeptide binding]; other site
568819002754	conserved gate region; other site
568819002755	putative PBP binding loops; other site
568819002756	ABC-ATPase subunit interface; other site
568819002757	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
568819002758	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162
568819002759	HPr interaction site; other site
568819002760	glycerol kinase (GK) interaction site [polypeptide binding]; other site
568819002761	active site
568819002762	phosphorylation site [posttranslational modification]
568819002763	CutC family; Region: CutC; cl01218
568819002764	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
568819002765	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927
568819002766	Predicted membrane protein (DUF2154); Region: DUF2154; cl12089
568819002767	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
568819002768	Histidine kinase; Region: HisKA_3; pfam07730
568819002769	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819002770	ATP binding site [chemical binding]; other site
568819002771	Mg2+ binding site [ion binding]; other site
568819002772	G-X-G motif; other site
568819002773	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
568819002774	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
568819002775	active site
568819002776	phosphorylation site [posttranslational modification]
568819002777	intermolecular recognition site; other site
568819002778	dimerization interface [polypeptide binding]; other site
568819002779	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
568819002780	DNA binding residues [nucleotide binding]
568819002781	dimerization interface [polypeptide binding]; other site
568819002782	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
568819002783	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819002784	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
568819002785	Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136
568819002786	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
568819002787	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
568819002788	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
568819002789	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
568819002790	Protein of unknown function (DUF1447); Region: DUF1447; cl11492
568819002791	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
568819002792	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
568819002793	active site
568819002794	motif I; other site
568819002795	motif II; other site
568819002796	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
568819002797	Transcriptional regulators [Transcription]; Region: PurR; COG1609
568819002798	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568819002799	DNA binding site [nucleotide binding]
568819002800	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
568819002801	ligand binding site [chemical binding]; other site
568819002802	dimerization interface [polypeptide binding]; other site
568819002803	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of...; Region: L-fuc_L-ara-isomerases; cd00578
568819002804	hexamer (dimer of trimers) interface [polypeptide binding]; other site
568819002805	trimer interface [polypeptide binding]; other site
568819002806	substrate binding site [chemical binding]; other site
568819002807	Mn binding site [ion binding]; other site
568819002808	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
568819002809	TPP-binding site [chemical binding]; other site
568819002810	dimer interface [polypeptide binding]; other site
568819002811	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
568819002812	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
568819002813	PYR/PP interface [polypeptide binding]; other site
568819002814	dimer interface [polypeptide binding]; other site
568819002815	TPP binding site [chemical binding]; other site
568819002816	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
568819002817	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
568819002818	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
568819002819	N- and C-terminal domain interface [polypeptide binding]; other site
568819002820	active site
568819002821	MgATP binding site [chemical binding]; other site
568819002822	catalytic site [active]
568819002823	metal binding site [ion binding]; metal-binding site
568819002824	carbohydrate binding site [chemical binding]; other site
568819002825	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
568819002826	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212
568819002827	active site turn [active]
568819002828	phosphorylation site [posttranslational modification]
568819002829	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
568819002830	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cd00210
568819002831	HPr interaction site; other site
568819002832	glycerol kinase (GK) interaction site [polypeptide binding]; other site
568819002833	active site
568819002834	phosphorylation site [posttranslational modification]
568819002835	Putative endoglucanase; Region: Glyco_hydro_101; pfam12905
568819002836	Protein of unknown function (DUF817); Region: DUF817; cl01520
568819002837	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
568819002838	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
568819002839	GTP binding site [chemical binding]; other site
568819002840	ModC is an ABC-type transporter and the ATPase component of a molybdate transport system that also includes the periplasmic binding protein ModA and the membrane protein ModB. ABC transporters are a large family of proteins involved in the transport of...; Region: ABC_ModC_molybdenum_transporter; cd03297
568819002841	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
568819002842	Walker A/P-loop; other site
568819002843	ATP binding site [chemical binding]; other site
568819002844	Q-loop/lid; other site
568819002845	ABC transporter signature motif; other site
568819002846	Walker B; other site
568819002847	D-loop; other site
568819002848	H-loop/switch region; other site
568819002849	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819002850	dimer interface [polypeptide binding]; other site
568819002851	conserved gate region; other site
568819002852	putative PBP binding loops; other site
568819002853	ABC-ATPase subunit interface; other site
568819002854	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
568819002855	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
568819002856	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
568819002857	dimer interface [polypeptide binding]; other site
568819002858	putative functional site; other site
568819002859	putative MPT binding site; other site
568819002860	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa...; Region: MobB; cd03116
568819002861	Walker A motif; other site
568819002862	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
568819002863	MoaE homodimer interface [polypeptide binding]; other site
568819002864	MoaD interaction [polypeptide binding]; other site
568819002865	active site residues [active]
568819002866	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
568819002867	MoaE interaction surface [polypeptide binding]; other site
568819002868	MoeB interaction surface [polypeptide binding]; other site
568819002869	thiocarboxylated glycine; other site
568819002870	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420
568819002871	trimer interface [polypeptide binding]; other site
568819002872	dimer interface [polypeptide binding]; other site
568819002873	putative active site [active]
568819002874	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
568819002875	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
568819002876	FeS/SAM binding site; other site
568819002877	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
568819002878	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886
568819002879	MPT binding site; other site
568819002880	trimer interface [polypeptide binding]; other site
568819002881	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
568819002882	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757
568819002883	ATP binding site [chemical binding]; other site
568819002884	substrate interface [chemical binding]; other site
568819002885	Flavin Reductases; Region: FlaRed; cl00801
568819002886	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487
568819002887	active site
568819002888	catalytic residues [active]
568819002889	metal binding site [ion binding]; metal-binding site
568819002890	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
568819002891	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
568819002892	TPP-binding site [chemical binding]; other site
568819002893	tetramer interface [polypeptide binding]; other site
568819002894	heterodimer interface [polypeptide binding]; other site
568819002895	phosphorylation loop region [posttranslational modification]
568819002896	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
568819002897	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
568819002898	alpha subunit interface [polypeptide binding]; other site
568819002899	TPP binding site [chemical binding]; other site
568819002900	heterodimer interface [polypeptide binding]; other site
568819002901	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
568819002902	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
568819002903	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
568819002904	E3 interaction surface; other site
568819002905	lipoyl attachment site [posttranslational modification]; other site
568819002906	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
568819002907	E3 interaction surface; other site
568819002908	lipoyl attachment site [posttranslational modification]; other site
568819002909	e3 binding domain; Region: E3_binding; pfam02817
568819002910	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
568819002911	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
568819002912	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819002913	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819002914	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
568819002915	Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039
568819002916	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl11406
568819002917	NAD(P) binding site [chemical binding]; other site
568819002918	LDH/MDH dimer interface [polypeptide binding]; other site
568819002919	substrate binding site [chemical binding]; other site
568819002920	Uncharacterised protein family (UPF0223); Region: UPF0223; cl11484
568819002921	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
568819002922	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
568819002923	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
568819002924	Protein of unknown function (DUF1054); Region: DUF1054; cl11544
568819002925	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1,6-; Region: IMPase_like; cd01637
568819002926	active site
568819002927	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
568819002928	TypA (tyrosine phosphorylated protein A)/BipA subfamily.  BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants.  BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891
568819002929	G1 box; other site
568819002930	putative GEF interaction site [polypeptide binding]; other site
568819002931	GTP/Mg2+ binding site [chemical binding]; other site
568819002932	Switch I region; other site
568819002933	G2 box; other site
568819002934	G3 box; other site
568819002935	Switch II region; other site
568819002936	G4 box; other site
568819002937	G5 box; other site
568819002938	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
568819002939	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a...; Region: BipA_TypA_C; cd03710
568819002940	Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; cl11558
568819002941	Protein of unknown function (DUF1507); Region: DUF1507; cl11487
568819002942	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
568819002943	pyruvate carboxylase; Reviewed; Region: PRK12999
568819002944	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
568819002945	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
568819002946	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
568819002947	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
568819002948	active site
568819002949	catalytic residues [active]
568819002950	metal binding site [ion binding]; metal-binding site
568819002951	homodimer binding site [polypeptide binding]; other site
568819002952	Conserved carboxylase domain; Region: PYC_OADA; pfam02436
568819002953	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850
568819002954	carboxyltransferase (CT) interaction site; other site
568819002955	biotinylation site [posttranslational modification]; other site
568819002956	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
568819002957	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
568819002958	putative binding site residues; other site
568819002959	ABC-2 type transporter; Region: ABC2_membrane; cl11417
568819002960	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
568819002961	ABC_KpsT_Wzt   The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export.  Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220
568819002962	Walker A/P-loop; other site
568819002963	ATP binding site [chemical binding]; other site
568819002964	Q-loop/lid; other site
568819002965	ABC transporter signature motif; other site
568819002966	Walker B; other site
568819002967	D-loop; other site
568819002968	H-loop/switch region; other site
568819002969	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743
568819002970	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
568819002971	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
568819002972	Ligand binding site [chemical binding]; other site
568819002973	Putative Catalytic site [active]
568819002974	DXD motif; other site
568819002975	conserved hypothetical integral membrane protein; Region: TIGR03766
568819002976	D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181
568819002977	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
568819002978	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
568819002979	active site
568819002980	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
568819002981	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
568819002982	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
568819002983	active site
568819002984	tetramer interface [polypeptide binding]; other site
568819002985	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
568819002986	substrate binding site [chemical binding]; other site
568819002987	dimer interface [polypeptide binding]; other site
568819002988	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
568819002989	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
568819002990	putative NAD(P) binding site [chemical binding]; other site
568819002991	putative catalytic Zn binding site [ion binding]; other site
568819002992	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
568819002993	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
568819002994	active site
568819002995	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
568819002996	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
568819002997	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
568819002998	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
568819002999	glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171
568819003000	active site
568819003001	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
568819003002	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_A; cd01570
568819003003	active site
568819003004	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
568819003005	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553
568819003006	homodimer interface [polypeptide binding]; other site
568819003007	NAD binding pocket [chemical binding]; other site
568819003008	ATP binding pocket [chemical binding]; other site
568819003009	Mg binding site [ion binding]; other site
568819003010	active-site loop [active]
568819003011	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
568819003012	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
568819003013	P-loop; other site
568819003014	active site
568819003015	phosphorylation site [posttranslational modification]
568819003016	GMP synthase; Reviewed; Region: guaA; PRK00074
568819003017	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
568819003018	AMP/PPi binding site [chemical binding]; other site
568819003019	candidate oxyanion hole; other site
568819003020	catalytic triad [active]
568819003021	potential glutamine specificity residues [chemical binding]; other site
568819003022	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
568819003023	ATP Binding subdomain [chemical binding]; other site
568819003024	Dimerization subdomain; other site
568819003025	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
568819003026	active site
568819003027	metal binding site [ion binding]; metal-binding site
568819003028	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
568819003029	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819003030	Walker A/P-loop; other site
568819003031	ATP binding site [chemical binding]; other site
568819003032	Q-loop/lid; other site
568819003033	ABC transporter signature motif; other site
568819003034	Walker B; other site
568819003035	D-loop; other site
568819003036	H-loop/switch region; other site
568819003037	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the...; Region: mcbC-like_oxidoreductase; cd02142
568819003038	putative FMN binding site [chemical binding]; other site
568819003039	NADPH bind site [chemical binding]; other site
568819003040	bacteriocin biosynthesis cyclodehydratase, SagC family; Region: cyclo_dehy_ocin; TIGR03603
568819003041	YcaO-like family; Region: YcaO; cl09146
568819003042	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
568819003043	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568819003044	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
568819003045	active site
568819003046	metal binding site [ion binding]; metal-binding site
568819003047	Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
568819003048	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819003049	ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules.  The...; Region: ABC_ATPase; cd00267
568819003050	Q-loop/lid; other site
568819003051	ABC transporter signature motif; other site
568819003052	Walker B; other site
568819003053	D-loop; other site
568819003054	H-loop/switch region; other site
568819003056	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
568819003057	MepB protein; Region: MepB; cl01985
568819003058	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
568819003059	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
568819003060	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
568819003061	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
568819003062	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
568819003063	DNA binding residues [nucleotide binding]
568819003064	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
568819003065	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
568819003066	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819003067	Walker A/P-loop; other site
568819003068	ATP binding site [chemical binding]; other site
568819003069	Q-loop/lid; other site
568819003070	ABC transporter signature motif; other site
568819003071	Walker B; other site
568819003072	D-loop; other site
568819003073	H-loop/switch region; other site
568819003074	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
568819003075	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
568819003076	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819003077	Walker A/P-loop; other site
568819003078	ATP binding site [chemical binding]; other site
568819003079	Q-loop/lid; other site
568819003080	ABC transporter signature motif; other site
568819003081	Walker B; other site
568819003082	D-loop; other site
568819003083	H-loop/switch region; other site
568819003084	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
568819003085	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
568819003086	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
568819003087	DNA binding residues [nucleotide binding]
568819003088	putative dimer interface [polypeptide binding]; other site
568819003090	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
568819003091	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
568819003092	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
568819003093	LRR adjacent; Region: LRR_adjacent; pfam08191
568819003094	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
568819003095	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
568819003096	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
568819003097	oligomer interface [polypeptide binding]; other site
568819003098	active site residues [active]
568819003099	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
568819003100	dimer interface [polypeptide binding]; other site
568819003101	precorrin-2 dehydrogenase; Validated; Region: PRK06719
568819003102	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
568819003103	SLBB domain; Region: SLBB; pfam10531
568819003104	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
568819003105	The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393
568819003106	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
568819003107	Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
568819003108	putative hexamer interface [polypeptide binding]; other site
568819003109	putative hexagonal pore; other site
568819003110	Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
568819003111	putative hexamer interface [polypeptide binding]; other site
568819003112	putative hexagonal pore; other site
568819003113	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
568819003114	putative hexamer interface [polypeptide binding]; other site
568819003115	putative hexagonal pore; other site
568819003116	Dynein light intermediate chain (DLIC); Region: DLIC; pfam05783
568819003117	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
568819003118	G3 box; other site
568819003119	Switch II region; other site
568819003120	GTP/Mg2+ binding site [chemical binding]; other site
568819003121	G4 box; other site
568819003122	G5 box; other site
568819003123	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is...; Region: CobU; cd00544
568819003124	homotrimer interface [polypeptide binding]; other site
568819003125	Walker A motif; other site
568819003126	GTP binding site [chemical binding]; other site
568819003127	Walker B motif; other site
568819003128	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
568819003129	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
568819003130	catalytic core [active]
568819003131	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
568819003132	Predicted histidine kinase sensor domain; Region: Hist_Kin_Sens; pfam10114
568819003133	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568819003134	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
568819003135	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568819003136	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
568819003137	Hexamer interface [polypeptide binding]; other site
568819003138	Hexagonal pore residue; other site
568819003139	propanediol utilization protein PduB; Provisional; Region: PRK15415
568819003140	Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047
568819003141	putative hexamer interface [polypeptide binding]; other site
568819003142	putative hexagonal pore; other site
568819003143	Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048
568819003144	putative hexamer interface [polypeptide binding]; other site
568819003145	putative hexagonal pore; other site
568819003146	Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909
568819003147	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1,2-...; Region: Dehydratase_LU; cd03687
568819003148	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
568819003149	alpha-beta subunit interface [polypeptide binding]; other site
568819003150	alpha-gamma subunit interface [polypeptide binding]; other site
568819003151	active site
568819003152	substrate and K+ binding site; other site
568819003153	K+ binding site [ion binding]; other site
568819003154	cobalamin binding site [chemical binding]; other site
568819003155	Dehydratase medium subunit; Region: Dehydratase_MU; cl03516
568819003156	Dehydratase small subunit; Region: Dehydratase_SU; cl02055
568819003157	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
568819003158	Dehydratase medium subunit; Region: Dehydratase_MU; cl03516
568819003159	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
568819003160	Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056
568819003161	putative hexamer interface [polypeptide binding]; other site
568819003162	putative hexagonal pore; other site
568819003163	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
568819003164	Hexamer interface [polypeptide binding]; other site
568819003165	Hexagonal pore residue; other site
568819003166	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
568819003167	Propanediol utilisation protein PduL; Region: PduL; pfam06130
568819003168	Propanediol utilisation protein PduL; Region: PduL; pfam06130
568819003169	Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820
568819003170	Cell division protein FtsA; Region: FtsA; cl11496
568819003171	putative propanediol utilization protein PduM; Provisional; Region: PRK15428
568819003172	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
568819003173	Hexamer/Pentamer interface [polypeptide binding]; other site
568819003174	central pore; other site
568819003175	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
568819003176	Domain of unknown function (DUF336); Region: DUF336; cl01249
568819003177	aldehyde dehydrogenase EutE; Provisional; Region: PRK15398
568819003178	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
568819003179	putative catalytic cysteine [active]
568819003180	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
568819003181	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
568819003182	putative active site [active]
568819003183	metal binding site [ion binding]; metal-binding site
568819003184	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cd00333
568819003185	amphipathic channel; other site
568819003186	Asn-Pro-Ala signature motifs; other site
568819003187	Acetokinase family; Region: Acetate_kinase; cl01029
568819003188	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
568819003189	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
568819003190	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819003191	homodimer interface [polypeptide binding]; other site
568819003192	catalytic residue [active]
568819003193	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542
568819003194	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
568819003195	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
568819003196	putative active site [active]
568819003197	metal binding site [ion binding]; metal-binding site
568819003198	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
568819003199	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
568819003200	active site
568819003201	phosphorylation site [posttranslational modification]
568819003202	intermolecular recognition site; other site
568819003203	dimerization interface [polypeptide binding]; other site
568819003204	ANTAR domain; Region: ANTAR; cl04297
568819003205	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
568819003206	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
568819003207	Histidine kinase; Region: HisKA_2; cl06527
568819003208	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819003209	ATP binding site [chemical binding]; other site
568819003210	Mg2+ binding site [ion binding]; other site
568819003211	G-X-G motif; other site
568819003212	reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719
568819003213	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
568819003214	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; cl09205
568819003215	Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762
568819003216	ethanolamine utilization protein EutL; Provisional; Region: PRK15405
568819003217	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049
568819003218	putative hexamer interface [polypeptide binding]; other site
568819003219	putative hexagonal pore; other site
568819003220	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050
568819003221	putative hexamer interface [polypeptide binding]; other site
568819003222	putative hexagonal pore; other site
568819003223	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
568819003224	Hexamer interface [polypeptide binding]; other site
568819003225	Hexagonal pore residue; other site
568819003226	acetaldehyde dehydrogenase (acetylating); Region: EutH_ACDH; TIGR02518
568819003227	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
568819003228	putative catalytic cysteine [active]
568819003229	Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
568819003230	Hexamer interface [polypeptide binding]; other site
568819003231	Putative hexagonal pore residue; other site
568819003232	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
568819003233	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
568819003234	Propanediol utilisation protein PduL; Region: PduL; pfam06130
568819003235	Propanediol utilisation protein PduL; Region: PduL; pfam06130
568819003236	ethanolamine utilization protein; Region: eut_hyp; TIGR02536
568819003237	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
568819003238	Hexamer/Pentamer interface [polypeptide binding]; other site
568819003239	central pore; other site
568819003240	ethanolamine utilization protein, PduT homolog; Region: eut_PduT; TIGR02526
568819003241	Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
568819003242	putative hexamer interface [polypeptide binding]; other site
568819003243	putative hexagonal pore; other site
568819003244	Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
568819003245	putative hexamer interface [polypeptide binding]; other site
568819003246	putative hexagonal pore; other site
568819003247	Ethanolamine utilisation protein, EutH; Region: EutH; cl01248
568819003248	Cupin domain; Region: Cupin_2; cl09118
568819003249	Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249
568819003250	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568819003251	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
568819003252	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568819003253	Protein of unknown function (DUF1393); Region: DUF1393; cl01942
568819003254	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
568819003255	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
568819003256	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
568819003257	catalytic triad [active]
568819003258	CobD/Cbib protein; Region: CobD_Cbib; cl00561
568819003259	Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913
568819003260	Precorrin-8X methylmutase; Region: CbiC; pfam02570
568819003261	CbiD; Region: CbiD; cl00828
568819003262	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
568819003263	cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287
568819003264	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
568819003265	S-adenosylmethionine binding site [chemical binding]; other site
568819003266	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
568819003267	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
568819003268	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
568819003269	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
568819003270	Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133
568819003271	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
568819003272	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
568819003273	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922
568819003274	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
568819003275	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
568819003276	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578
568819003277	active site
568819003278	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
568819003279	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412
568819003280	active site
568819003281	C-terminal domain interface [polypeptide binding]; other site
568819003282	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
568819003283	active site
568819003284	N-terminal domain interface [polypeptide binding]; other site
568819003285	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
568819003286	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397
568819003287	Cobalt transport protein component CbiN; Region: CbiN; cl00842
568819003288	Cobalt transport protein; Region: CbiQ; cl00463
568819003289	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638
568819003290	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This...; Region: ABC_cobalt_CbiO_domain1; cd03225
568819003291	Walker A/P-loop; other site
568819003292	ATP binding site [chemical binding]; other site
568819003293	Q-loop/lid; other site
568819003294	ABC transporter signature motif; other site
568819003295	Walker B; other site
568819003296	D-loop; other site
568819003297	H-loop/switch region; other site
568819003298	cobyric acid synthase; Provisional; Region: PRK00784
568819003299	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
568819003300	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
568819003301	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
568819003302	catalytic triad [active]
568819003303	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
568819003304	Protein of unknown function, DUF606; Region: DUF606; cl01273
568819003305	Protein of unknown function, DUF606; Region: DUF606; cl01273
568819003306	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819003307	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819003308	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
568819003309	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743
568819003310	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743
568819003311	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
568819003312	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
568819003313	oligomer interface [polypeptide binding]; other site
568819003314	active site
568819003315	metal binding site [ion binding]; metal-binding site
568819003316	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
568819003317	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
568819003318	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
568819003319	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819003320	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
568819003321	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
568819003322	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
568819003323	dimer interface [polypeptide binding]; other site
568819003324	motif 1; other site
568819003325	active site
568819003326	motif 2; other site
568819003327	motif 3; other site
568819003328	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
568819003329	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
568819003330	putative tRNA-binding site [nucleotide binding]; other site
568819003331	B3/4 domain; Region: B3_4; cl11458
568819003332	tRNA synthetase B5 domain; Region: B5; cl08394
568819003333	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
568819003334	dimer interface [polypeptide binding]; other site
568819003335	motif 1; other site
568819003336	motif 3; other site
568819003337	motif 2; other site
568819003338	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386
568819003339	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
568819003340	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
568819003341	Walker A/P-loop; other site
568819003342	ATP binding site [chemical binding]; other site
568819003343	Q-loop/lid; other site
568819003344	ABC transporter signature motif; other site
568819003345	Walker B; other site
568819003346	D-loop; other site
568819003347	H-loop/switch region; other site
568819003348	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
568819003349	FtsX-like permease family; Region: FtsX; pfam02687
568819003350	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
568819003351	FtsX-like permease family; Region: FtsX; pfam02687
568819003352	Transcriptional regulators [Transcription]; Region: MarR; COG1846
568819003353	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819003354	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
568819003355	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
568819003356	ligand binding site [chemical binding]; other site
568819003357	active site
568819003358	UGI interface [polypeptide binding]; other site
568819003359	catalytic site [active]
568819003360	ribonuclease HIII; Provisional; Region: PRK00996
568819003361	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
568819003362	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
568819003363	RNA/DNA hybrid binding site [nucleotide binding]; other site
568819003364	active site
568819003365	Cell division protein ZapA; Region: ZapA; cl01146
568819003366	Colicin V production protein; Region: Colicin_V; cl00567
568819003367	hypothetical protein; Provisional; Region: PRK08609
568819003368	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
568819003369	active site
568819003370	primer binding site [nucleotide binding]; other site
568819003371	NTP  binding site [chemical binding]; other site
568819003372	metal binding triad [ion binding]; metal-binding site
568819003373	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
568819003374	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
568819003375	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819003376	Walker A/P-loop; other site
568819003377	ATP binding site [chemical binding]; other site
568819003378	Q-loop/lid; other site
568819003379	ABC transporter signature motif; other site
568819003380	Walker B; other site
568819003381	D-loop; other site
568819003382	H-loop/switch region; other site
568819003383	Smr domain; Region: Smr; cl02619
568819003384	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
568819003385	catalytic residues [active]
568819003386	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
568819003387	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
568819003388	GIY-YIG motif/motif A; other site
568819003389	active site
568819003390	catalytic site [active]
568819003391	putative DNA binding site [nucleotide binding]; other site
568819003392	metal binding site [ion binding]; metal-binding site
568819003393	UvrB/uvrC motif; Region: UVR; pfam02151
568819003394	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
568819003395	aspartate kinase; Reviewed; Region: PRK06635
568819003396	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
568819003397	putative nucleotide binding site [chemical binding]; other site
568819003398	putative catalytic residues [active]
568819003399	putative Mg ion binding site [ion binding]; other site
568819003400	putative aspartate binding site [chemical binding]; other site
568819003401	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
568819003402	putative allosteric regulatory site; other site
568819003403	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
568819003404	Protein of unknown function (DUF2507); Region: DUF2507; pfam10702
568819003405	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
568819003406	ribonuclease PH; Reviewed; Region: rph; PRK00173
568819003407	3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138
568819003408	3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725
568819003409	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515
568819003410	active site
568819003411	dimerization interface [polypeptide binding]; other site
568819003412	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
568819003413	active site
568819003414	metal binding site [ion binding]; metal-binding site
568819003415	homotetramer interface [polypeptide binding]; other site
568819003416	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
568819003417	LRR adjacent; Region: LRR_adjacent; pfam08191
568819003418	MucBP domain; Region: MucBP; pfam06458
568819003419	MucBP domain; Region: MucBP; pfam06458
568819003420	Uncharacterized conserved protein [Function unknown]; Region: COG5361
568819003421	Protein of unknown function (DUF1254); Region: DUF1254; cl02257
568819003422	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
568819003423	Protein of unknown function (DUF419); Region: DUF419; cl15265
568819003424	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
568819003425	dimer interface [polypeptide binding]; other site
568819003426	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
568819003427	Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300
568819003428	catalytic core [active]
568819003429	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
568819003430	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif (...; Region: DEADc; cd00268
568819003431	ATP binding site [chemical binding]; other site
568819003432	Mg++ binding site [ion binding]; other site
568819003433	motif III; other site
568819003434	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568819003435	nucleotide binding region [chemical binding]; other site
568819003436	ATP-binding site [chemical binding]; other site
568819003437	DbpA RNA binding domain; Region: DbpA; pfam03880
568819003438	Protein of unknown function (DUF3116); Region: DUF3116; pfam11313
568819003439	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
568819003440	putative active site [active]
568819003441	nucleotide binding site [chemical binding]; other site
568819003442	nudix motif; other site
568819003443	putative metal binding site [ion binding]; other site
568819003444	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819003445	putative substrate translocation pore; other site
568819003446	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
568819003447	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819003448	Uncharacterized conserved protein [Function unknown]; Region: COG1284
568819003449	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
568819003450	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498
568819003451	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
568819003452	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819003453	DNA-binding site [nucleotide binding]; DNA binding site
568819003454	UTRA domain; Region: UTRA; cl01230
568819003455	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
568819003456	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
568819003457	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212
568819003458	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
568819003459	active site turn [active]
568819003460	phosphorylation site [posttranslational modification]
568819003461	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
568819003462	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
568819003463	nudix motif; other site
568819003464	Protein of unknown function (DUF877); Region: DUF877; cl05484
568819003465	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
568819003466	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
568819003467	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
568819003468	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
568819003469	putative catalytic cysteine [active]
568819003470	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
568819003471	nucleotide binding site [chemical binding]; other site
568819003472	homotetrameric interface [polypeptide binding]; other site
568819003473	putative phosphate binding site [ion binding]; other site
568819003474	putative allosteric binding site; other site
568819003475	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
568819003476	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
568819003477	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568819003478	non-specific DNA binding site [nucleotide binding]; other site
568819003479	salt bridge; other site
568819003480	sequence-specific DNA binding site [nucleotide binding]; other site
568819003481	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
568819003482	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...; Region: ZnMc; cl00064
568819003483	active site
568819003484	trigger factor; Provisional; Region: tig; PRK01490
568819003485	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
568819003486	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
568819003487	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
568819003488	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
568819003489	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
568819003490	Walker A motif; other site
568819003491	ATP binding site [chemical binding]; other site
568819003492	Walker B motif; other site
568819003493	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
568819003494	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
568819003495	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
568819003496	Catalytic site [active]
568819003497	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
568819003498	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
568819003499	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
568819003500	Catalytic site [active]
568819003501	Peptidase S26; Region: Peptidase_S26; pfam10502
568819003502	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
568819003503	Catalytic site [active]
568819003504	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
568819003505	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
568819003506	YlqF.  Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases...; Region: YlqF; cd01856
568819003507	GTP/Mg2+ binding site [chemical binding]; other site
568819003508	G4 box; other site
568819003509	G5 box; other site
568819003510	G1 box; other site
568819003511	Switch I region; other site
568819003512	G2 box; other site
568819003513	G3 box; other site
568819003514	Switch II region; other site
568819003515	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
568819003516	RNA/DNA hybrid binding site [nucleotide binding]; other site
568819003517	active site
568819003518	DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695
568819003519	DNA topoisomerase I; Validated; Region: PRK05582
568819003520	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363
568819003521	active site
568819003522	interdomain interaction site; other site
568819003523	putative metal-binding site [ion binding]; other site
568819003524	nucleotide binding site [chemical binding]; other site
568819003525	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186
568819003526	domain I; other site
568819003527	DNA binding groove [nucleotide binding]
568819003528	phosphate binding site [ion binding]; other site
568819003529	domain II; other site
568819003530	domain III; other site
568819003531	nucleotide binding site [chemical binding]; other site
568819003532	catalytic site [active]
568819003533	domain IV; other site
568819003534	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977
568819003535	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977
568819003536	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819003537	Glucose inhibited division protein A; Region: GIDA; pfam01134
568819003538	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
568819003539	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
568819003540	DNA binding site [nucleotide binding]
568819003541	Int/Topo IB signature motif; other site
568819003542	active site
568819003543	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
568819003544	active site
568819003545	HslU subunit interaction site [polypeptide binding]; other site
568819003546	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
568819003547	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
568819003548	Walker A motif; other site
568819003549	ATP binding site [chemical binding]; other site
568819003550	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819003551	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
568819003552	transcriptional repressor CodY; Validated; Region: PRK04158
568819003553	CodY GAF-like domain; Region: CodY; pfam06018
568819003554	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
568819003555	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586
568819003556	active site
568819003557	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
568819003558	Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017
568819003559	active site
568819003560	catalytic residues [active]
568819003561	Domain of unknown function (DUF205); Region: DUF205; cl00410
568819003562	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819003563	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
568819003564	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
568819003565	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822
568819003566	anchoring element; other site
568819003567	dimer interface [polypeptide binding]; other site
568819003568	ATP binding site [chemical binding]; other site
568819003569	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366
568819003570	active site
568819003571	putative metal-binding site [ion binding]; other site
568819003572	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
568819003573	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
568819003574	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187
568819003575	CAP-like domain; other site
568819003576	Active site [active]
568819003577	primary dimer interface [polypeptide binding]; other site
568819003578	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
568819003579	S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802
568819003580	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
568819003581	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
568819003582	catalytic triad [active]
568819003583	catalytic triad [active]
568819003584	oxyanion hole [active]
568819003585	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
568819003586	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
568819003587	active site
568819003588	catalytic site [active]
568819003589	metal binding site [ion binding]; metal-binding site
568819003590	dimer interface [polypeptide binding]; other site
568819003591	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
568819003592	IPP transferase; Region: IPPT; cl00403
568819003593	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members...; Region: Sm_like; cl00259
568819003594	Sm1 motif; other site
568819003595	D3 - B interaction site; other site
568819003596	D1 - D2 interaction site; other site
568819003597	Hfq - Hfq interaction site; other site
568819003598	RNA binding pocket [nucleotide binding]; other site
568819003599	Sm2 motif; other site
568819003600	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
568819003601	HflX subfamily.  A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily.  The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878
568819003602	G1 box; other site
568819003603	GTP/Mg2+ binding site [chemical binding]; other site
568819003604	Switch I region; other site
568819003605	G2 box; other site
568819003606	G3 box; other site
568819003607	Switch II region; other site
568819003608	G4 box; other site
568819003609	G5 box; other site
568819003610	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
568819003611	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
568819003612	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
568819003613	catalytic residue [active]
568819003614	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
568819003615	DNA binding residues [nucleotide binding]
568819003616	putative dimer interface [polypeptide binding]; other site
568819003617	glutamine synthetase, type I; Region: GlnA; TIGR00653
568819003618	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
568819003619	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
568819003620	arsenical pump membrane protein; Provisional; Region: PRK15445
568819003621	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
568819003622	transmembrane helices; other site
568819003623	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
568819003624	LexA repressor; Validated; Region: PRK00215
568819003625	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819003626	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529
568819003627	Catalytic site [active]
568819003628	cell division suppressor protein YneA; Provisional; Region: PRK14125
568819003629	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107
568819003630	Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722
568819003631	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
568819003632	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
568819003633	TPP-binding site [chemical binding]; other site
568819003634	dimer interface [polypeptide binding]; other site
568819003635	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
568819003636	PYR/PP interface [polypeptide binding]; other site
568819003637	dimer interface [polypeptide binding]; other site
568819003638	TPP binding site [chemical binding]; other site
568819003639	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
568819003640	Uncharacterised protein family (UPF0154); Region: UPF0154; cl01536
568819003641	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
568819003642	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
568819003643	S-adenosylmethionine binding site [chemical binding]; other site
568819003644	ParB-like nuclease domain; Region: ParBc; cl02129
568819003645	Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969
568819003646	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
568819003647	Active Sites [active]
568819003648	Domain of unknown function (DUF3440); Region: DUF3440; pfam11922
568819003649	DEAD-like helicases superfamily; Region: DEXDc; smart00487
568819003650	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
568819003651	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
568819003652	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254
568819003653	putative nucleotide binding site [chemical binding]; other site
568819003654	uridine monophosphate binding site [chemical binding]; other site
568819003655	homohexameric interface [polypeptide binding]; other site
568819003656	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
568819003657	hinge region; other site
568819003658	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
568819003659	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
568819003660	catalytic residue [active]
568819003661	putative FPP diphosphate  binding site; other site
568819003662	putative FPP binding hydrophobic cleft; other site
568819003663	dimer interface [polypeptide binding]; other site
568819003664	putative IPP diphosphate binding site; other site
568819003665	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
568819003666	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
568819003667	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
568819003668	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
568819003669	RIP metalloprotease RseP; Region: TIGR00054
568819003670	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
568819003671	active site
568819003672	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
568819003673	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989
568819003674	protein binding site [polypeptide binding]; other site
568819003675	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
568819003676	putative substrate binding region [chemical binding]; other site
568819003677	prolyl-tRNA synthetase; Provisional; Region: PRK09194
568819003678	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779
568819003679	dimer interface [polypeptide binding]; other site
568819003680	motif 1; other site
568819003681	active site
568819003682	motif 2; other site
568819003683	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334
568819003684	putative deacylase active site [active]
568819003685	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
568819003686	active site
568819003687	motif 3; other site
568819003688	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861
568819003689	anticodon binding site; other site
568819003690	DNA polymerase III PolC; Validated; Region: polC; PRK00448
568819003691	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
568819003692	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
568819003693	generic binding surface II; other site
568819003694	generic binding surface I; other site
568819003695	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
568819003696	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
568819003697	active site
568819003698	substrate binding site [chemical binding]; other site
568819003699	catalytic site [active]
568819003700	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
568819003701	ribosome maturation protein RimP; Reviewed; Region: PRK00092
568819003702	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members...; Region: Sm_like; cl00259
568819003703	YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold.  The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734
568819003704	Sm1 motif; other site
568819003705	predicted subunit interaction site [polypeptide binding]; other site
568819003706	RNA binding pocket [nucleotide binding]; other site
568819003707	Sm2 motif; other site
568819003708	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
568819003709	NusA N-terminal domain; Region: NusA_N; pfam08529
568819003710	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455
568819003711	RNA binding site [nucleotide binding]; other site
568819003712	homodimer interface [polypeptide binding]; other site
568819003713	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
568819003714	G-X-X-G motif; other site
568819003715	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
568819003716	putative RNA binding cleft [nucleotide binding]; other site
568819003717	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
568819003718	translation initiation factor IF-2; Validated; Region: infB; PRK05306
568819003719	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
568819003720	translation initiation factor IF-2; Region: IF-2; TIGR00487
568819003721	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
568819003722	IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily.  IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits.  As seen in other GTPases...; Region: IF2_eIF5B; cd01887
568819003723	G1 box; other site
568819003724	putative GEF interaction site [polypeptide binding]; other site
568819003725	GTP/Mg2+ binding site [chemical binding]; other site
568819003726	Switch I region; other site
568819003727	G2 box; other site
568819003728	G3 box; other site
568819003729	Switch II region; other site
568819003730	G4 box; other site
568819003731	G5 box; other site
568819003732	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702
568819003733	Translation-initiation factor 2; Region: IF-2; pfam11987
568819003734	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692
568819003735	Protein of unknown function (DUF503); Region: DUF503; cl00669
568819003736	Ribosome-binding factor A; Region: RBFA; cl00542
568819003737	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550
568819003738	PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573
568819003739	RNA binding site [nucleotide binding]; other site
568819003740	active site
568819003741	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
568819003742	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
568819003743	active site
568819003744	Riboflavin kinase; Region: Flavokinase; cl03312
568819003745	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353
568819003746	16S/18S rRNA binding site [nucleotide binding]; other site
568819003747	S13e-L30e interaction site [polypeptide binding]; other site
568819003748	25S rRNA binding site [nucleotide binding]; other site
568819003749	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
568819003750	3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138
568819003751	3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725
568819003752	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
568819003753	3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138
568819003754	3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725
568819003755	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
568819003756	putative nucleic acid binding region [nucleotide binding]; other site
568819003757	G-X-X-G motif; other site
568819003758	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472
568819003759	RNA binding site [nucleotide binding]; other site
568819003760	domain interface; other site
568819003761	GTPase RsgA; Reviewed; Region: PRK01889
568819003762	YjeQ/EngC.  YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854
568819003763	GTPase/OB domain interface [polypeptide binding]; other site
568819003764	GTPase/Zn-binding domain interface [polypeptide binding]; other site
568819003765	GTP/Mg2+ binding site [chemical binding]; other site
568819003766	G4 box; other site
568819003767	G5 box; other site
568819003768	G1 box; other site
568819003769	Switch I region; other site
568819003770	G2 box; other site
568819003771	G3 box; other site
568819003772	Switch II region; other site
568819003773	proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675
568819003774	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
568819003775	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
568819003776	intramembrane serine protease GlpG; Provisional; Region: PRK10907
568819003777	Rhomboid family; Region: Rhomboid; cl11446
568819003778	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
568819003779	TPR motif; other site
568819003780	binding surface
568819003781	Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543
568819003782	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
568819003783	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
568819003784	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
568819003785	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
568819003786	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
568819003787	Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
568819003788	Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
568819003789	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819003790	Walker A motif; other site
568819003791	ATP binding site [chemical binding]; other site
568819003792	Walker B motif; other site
568819003793	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
568819003794	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
568819003795	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
568819003796	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
568819003797	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613
568819003798	tetramer interface [polypeptide binding]; other site
568819003799	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819003800	catalytic residue [active]
568819003801	Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003
568819003802	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613
568819003803	tetramer interface [polypeptide binding]; other site
568819003804	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819003805	catalytic residue [active]
568819003806	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
568819003807	active site residue [active]
568819003808	Protein of unknown function (DUF1385); Region: DUF1385; cl01595
568819003809	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
568819003810	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
568819003811	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
568819003812	active site
568819003813	elongation factor P; Validated; Region: PRK00529
568819003814	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
568819003815	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470
568819003816	RNA binding site [nucleotide binding]; other site
568819003817	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794
568819003818	RNA binding site [nucleotide binding]; other site
568819003819	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
568819003820	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850
568819003821	carboxyltransferase (CT) interaction site; other site
568819003822	biotinylation site [posttranslational modification]; other site
568819003823	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
568819003824	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
568819003825	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
568819003826	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
568819003827	Protein of unknown function (DUF322); Region: DUF322; cl00574
568819003828	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
568819003829	putative RNA binding site [nucleotide binding]; other site
568819003830	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14170
568819003831	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
568819003832	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
568819003833	homodimer interface [polypeptide binding]; other site
568819003834	NADP binding site [chemical binding]; other site
568819003835	substrate binding site [chemical binding]; other site
568819003836	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
568819003837	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489
568819003838	generic binding surface II; other site
568819003839	generic binding surface I; other site
568819003840	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
568819003841	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
568819003842	substrate binding pocket [chemical binding]; other site
568819003843	chain length determination region; other site
568819003844	substrate-Mg2+ binding site; other site
568819003845	catalytic residues [active]
568819003846	aspartate-rich region 1; other site
568819003847	active site lid residues [active]
568819003848	aspartate-rich region 2; other site
568819003849	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458
568819003850	DNA-binding site [nucleotide binding]; DNA binding site
568819003851	RNA-binding motif; other site
568819003852	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
568819003853	TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007
568819003854	TPP-binding site; other site
568819003855	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
568819003856	PYR/PP interface [polypeptide binding]; other site
568819003857	dimer interface [polypeptide binding]; other site
568819003858	TPP binding site [chemical binding]; other site
568819003859	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
568819003860	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
568819003861	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
568819003862	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
568819003863	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
568819003864	arginine repressor; Provisional; Region: PRK04280
568819003865	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
568819003866	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
568819003867	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241
568819003868	Walker A/P-loop; other site
568819003869	ATP binding site [chemical binding]; other site
568819003870	Q-loop/lid; other site
568819003871	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241
568819003872	ABC transporter signature motif; other site
568819003873	Walker B; other site
568819003874	D-loop; other site
568819003875	H-loop/switch region; other site
568819003876	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
568819003877	Acetokinase family; Region: Acetate_kinase; cl01029
568819003878	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
568819003879	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819003880	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
568819003881	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
568819003882	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
568819003883	tetramer interface [polypeptide binding]; other site
568819003884	TPP-binding site [chemical binding]; other site
568819003885	heterodimer interface [polypeptide binding]; other site
568819003886	phosphorylation loop region [posttranslational modification]
568819003887	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
568819003888	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
568819003889	alpha subunit interface [polypeptide binding]; other site
568819003890	TPP binding site [chemical binding]; other site
568819003891	heterodimer interface [polypeptide binding]; other site
568819003892	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
568819003893	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
568819003894	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
568819003895	E3 interaction surface; other site
568819003896	lipoyl attachment site [posttranslational modification]; other site
568819003897	e3 binding domain; Region: E3_binding; pfam02817
568819003898	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
568819003899	peptidase T-like protein; Region: PepT-like; TIGR01883
568819003900	M28, and M42; Region: Zinc_peptidase_like; cl14876
568819003901	metal binding site [ion binding]; metal-binding site
568819003902	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819003903	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
568819003904	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
568819003905	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568819003906	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
568819003907	active site
568819003908	phosphorylation site [posttranslational modification]
568819003909	intermolecular recognition site; other site
568819003910	dimerization interface [polypeptide binding]; other site
568819003911	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
568819003912	DNA binding site [nucleotide binding]
568819003913	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
568819003914	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
568819003915	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
568819003916	dimer interface [polypeptide binding]; other site
568819003917	phosphorylation site [posttranslational modification]
568819003918	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819003919	ATP binding site [chemical binding]; other site
568819003920	Mg2+ binding site [ion binding]; other site
568819003921	G-X-G motif; other site
568819003922	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
568819003923	Acylphosphatase; Region: Acylphosphatase; cl00551
568819003924	Protein of unknown function (DUF1033); Region: DUF1033; cl11549
568819003925	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
568819003926	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal...; Region: IDI-2_FMN; cd02811
568819003927	homotetramer interface [polypeptide binding]; other site
568819003928	FMN binding site [chemical binding]; other site
568819003929	homodimer contacts [polypeptide binding]; other site
568819003930	putative active site [active]
568819003931	putative substrate binding site [chemical binding]; other site
568819003932	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
568819003933	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
568819003934	active site residue [active]
568819003935	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
568819003936	Uncharacterized conserved protein [Function unknown]; Region: COG1284
568819003937	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
568819003938	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498
568819003939	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819003940	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
568819003941	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819003942	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
568819003943	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
568819003944	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
568819003945	ligand binding site [chemical binding]; other site
568819003946	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
568819003947	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216
568819003948	Walker A/P-loop; other site
568819003949	ATP binding site [chemical binding]; other site
568819003950	Q-loop/lid; other site
568819003951	ABC transporter signature motif; other site
568819003952	Walker B; other site
568819003953	D-loop; other site
568819003954	H-loop/switch region; other site
568819003955	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215
568819003956	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580
568819003957	TM-ABC transporter signature motif; other site
568819003958	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580
568819003959	TM-ABC transporter signature motif; other site
568819003960	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
568819003961	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
568819003962	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
568819003963	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
568819003964	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
568819003965	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
568819003966	classical (c) SDRs; Region: SDR_c; cd05233
568819003967	NAD(P) binding site [chemical binding]; other site
568819003968	active site
568819003969	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
568819003970	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
568819003971	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
568819003972	competence damage-inducible protein A; Provisional; Region: PRK00549
568819003973	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
568819003974	putative MPT binding site; other site
568819003975	Competence-damaged protein; Region: CinA; cl00666
568819003976	recombinase A; Provisional; Region: recA; PRK09354
568819003977	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
568819003978	hexamer interface [polypeptide binding]; other site
568819003979	Walker A motif; other site
568819003980	ATP binding site [chemical binding]; other site
568819003981	Walker B motif; other site
568819003982	phosphodiesterase; Provisional; Region: PRK12704
568819003983	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
568819003984	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
568819003985	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568819003986	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
568819003987	Coenzyme A binding pocket [chemical binding]; other site
568819003988	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
568819003989	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
568819003990	putative active site [active]
568819003991	metal binding site [ion binding]; metal-binding site
568819003992	homodimer binding site [polypeptide binding]; other site
568819003993	Protein of unknown function (DUF964); Region: DUF964; cl01483
568819003994	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
568819003995	MutS domain I; Region: MutS_I; pfam01624
568819003996	MutS domain II; Region: MutS_II; pfam05188
568819003997	MutS family domain IV; Region: MutS_IV; pfam05190
568819003998	MutS1 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284
568819003999	Walker A/P-loop; other site
568819004000	ATP binding site [chemical binding]; other site
568819004001	Q-loop/lid; other site
568819004002	ABC transporter signature motif; other site
568819004003	Walker B; other site
568819004004	D-loop; other site
568819004005	H-loop/switch region; other site
568819004006	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
568819004007	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819004008	ATP binding site [chemical binding]; other site
568819004009	Mg2+ binding site [ion binding]; other site
568819004010	G-X-G motif; other site
568819004011	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
568819004012	ATP binding site [chemical binding]; other site
568819004013	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
568819004014	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
568819004015	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
568819004016	Pyruvate formate lyase 1; Region: PFL1; cd01678
568819004017	coenzyme A binding site [chemical binding]; other site
568819004018	active site
568819004019	catalytic residues [active]
568819004020	glycine loop; other site
568819004021	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
568819004022	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
568819004023	FeS/SAM binding site; other site
568819004024	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819004025	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819004026	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568819004027	putative substrate translocation pore; other site
568819004028	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
568819004029	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819004030	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
568819004031	putative acyltransferase; Provisional; Region: PRK05790
568819004032	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
568819004033	dimer interface [polypeptide binding]; other site
568819004034	active site
568819004035	'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by...; Region: init_cond_enzymes; cd00827
568819004036	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
568819004037	dimer interface [polypeptide binding]; other site
568819004038	active site
568819004039	VanZ like family; Region: VanZ; cl01971
568819004040	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
568819004041	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819004042	Uncharacterized conserved protein [Function unknown]; Region: COG3379
568819004043	Sulfatase; Region: Sulfatase; cl10460
568819004044	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
568819004045	Domain of unknown function DUF20; Region: UPF0118; cl00465
568819004046	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
568819004047	FAD binding domain; Region: FAD_binding_4; pfam01565
568819004048	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
568819004049	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
568819004050	OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment.  ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family...; Region: ABC_OpuCA_Osmoprotection; cd03295
568819004051	Walker A/P-loop; other site
568819004052	ATP binding site [chemical binding]; other site
568819004053	Q-loop/lid; other site
568819004054	ABC transporter signature motif; other site
568819004055	Walker B; other site
568819004056	D-loop; other site
568819004057	H-loop/switch region; other site
568819004058	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819004059	dimer interface [polypeptide binding]; other site
568819004060	conserved gate region; other site
568819004061	ABC-ATPase subunit interface; other site
568819004062	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
568819004063	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
568819004064	Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096
568819004065	Natural resistance-associated macrophage protein; Region: Nramp; cl00836
568819004066	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819004067	dimer interface [polypeptide binding]; other site
568819004068	conserved gate region; other site
568819004069	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
568819004070	ABC-ATPase subunit interface; other site
568819004071	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
568819004072	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
568819004073	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819004074	dimer interface [polypeptide binding]; other site
568819004075	conserved gate region; other site
568819004076	putative PBP binding loops; other site
568819004077	ABC-ATPase subunit interface; other site
568819004078	OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment.  ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family...; Region: ABC_OpuCA_Osmoprotection; cd03295
568819004079	glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186
568819004080	Walker A/P-loop; other site
568819004081	ATP binding site [chemical binding]; other site
568819004082	Q-loop/lid; other site
568819004083	ABC transporter signature motif; other site
568819004084	Walker B; other site
568819004085	D-loop; other site
568819004086	H-loop/switch region; other site
568819004087	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
568819004088	Protein of unknown function (DUF1393); Region: DUF1393; cl01942
568819004089	Protein of unknown function (DUF419); Region: DUF419; cl15265
568819004090	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
568819004091	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
568819004092	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819004093	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
568819004094	ABC transporter; Region: ABC_tran_2; pfam12848
568819004095	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
568819004096	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819004097	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
568819004098	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819004099	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
568819004100	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
568819004101	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
568819004102	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
568819004103	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
568819004104	dihydrodipicolinate synthase; Region: dapA; TIGR00674
568819004105	dimer interface [polypeptide binding]; other site
568819004106	active site
568819004107	catalytic residue [active]
568819004108	aspartate kinase I; Reviewed; Region: PRK08210
568819004109	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
568819004110	nucleotide binding site [chemical binding]; other site
568819004111	substrate binding site [chemical binding]; other site
568819004112	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914
568819004113	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937
568819004114	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
568819004115	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819004116	Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774
568819004117	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
568819004118	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
568819004119	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
568819004120	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
568819004121	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
568819004122	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
568819004123	Protein of unknown function (DUF1189); Region: DUF1189; pfam06691
568819004124	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
568819004125	1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612
568819004126	AzlC protein; Region: AzlC; cl00570
568819004127	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
568819004128	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
568819004129	PPIC-type PPIASE domain; Region: Rotamase; cl08278
568819004130	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
568819004131	metal binding site 2 [ion binding]; metal-binding site
568819004132	putative DNA binding helix; other site
568819004133	metal binding site 1 [ion binding]; metal-binding site
568819004134	dimer interface [polypeptide binding]; other site
568819004135	structural Zn2+ binding site [ion binding]; other site
568819004136	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
568819004137	ABC-ATPase subunit  interface; other site
568819004138	dimer interface [polypeptide binding]; other site
568819004139	putative PBP binding regions; other site
568819004140	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
568819004141	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235
568819004142	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
568819004143	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl15354
568819004144	DHHA2 domain; Region: DHHA2; pfam02833
568819004145	endonuclease IV; Provisional; Region: PRK01060
568819004146	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cd00019
568819004147	AP (apurinic/apyrimidinic) site pocket; other site
568819004148	DNA interaction; other site
568819004149	Metal-binding active site; metal-binding site
568819004150	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif (...; Region: DEADc; cd00268
568819004151	DEAD-like helicases superfamily; Region: DEXDc; smart00487
568819004152	ATP binding site [chemical binding]; other site
568819004153	Mg++ binding site [ion binding]; other site
568819004154	motif III; other site
568819004155	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568819004156	nucleotide binding region [chemical binding]; other site
568819004157	ATP-binding site [chemical binding]; other site
568819004158	LytB protein; Region: LYTB; cl00507
568819004159	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
568819004160	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412
568819004161	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412
568819004162	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412
568819004163	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
568819004164	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
568819004165	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
568819004166	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
568819004167	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
568819004168	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
568819004169	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
568819004170	DNA binding residues [nucleotide binding]
568819004171	DNA primase; Validated; Region: dnaG; PRK05667
568819004172	CHC2 zinc finger; Region: zf-CHC2; cl02597
568819004173	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
568819004174	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
568819004175	active site
568819004176	metal binding site [ion binding]; metal-binding site
568819004177	interdomain interaction site; other site
568819004178	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
568819004179	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727
568819004180	Domain of unknown function (DUF299); Region: DUF299; cl00780
568819004181	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
568819004182	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
568819004183	glycyl-tRNA synthetase, tetrameric type, alpha subunit; Region: glyQ; TIGR00388
568819004184	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
568819004185	dimer interface [polypeptide binding]; other site
568819004186	motif 1; other site
568819004187	active site
568819004188	motif 2; other site
568819004189	motif 3; other site
568819004190	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
568819004191	Recombination protein O N terminal; Region: RecO_N; pfam11967
568819004192	Recombination protein O C terminal; Region: RecO_C; pfam02565
568819004193	Telomeric repeat-binding factor 2; Region: TRF2; pfam11611
568819004194	GTPase Era; Reviewed; Region: era; PRK00089
568819004195	Era subfamily.  Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria.  It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163
568819004196	G1 box; other site
568819004197	GTP/Mg2+ binding site [chemical binding]; other site
568819004198	Switch I region; other site
568819004199	G2 box; other site
568819004200	Switch II region; other site
568819004201	G3 box; other site
568819004202	G4 box; other site
568819004203	G5 box; other site
568819004204	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098
568819004205	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
568819004206	active site
568819004207	catalytic motif [active]
568819004208	Zn binding site [ion binding]; other site
568819004209	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526
568819004210	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
568819004211	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
568819004212	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
568819004213	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
568819004214	Zn2+ binding site [ion binding]; other site
568819004215	Mg2+ binding site [ion binding]; other site
568819004216	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
568819004217	PhoH-like protein; Region: PhoH; cl12134
568819004218	GatB domain; Region: GatB_Yqey; cl11497
568819004219	Ribosomal protein S21; Region: Ribosomal_S21; cl00529
568819004220	RNA methyltransferase; Region: Methyltrans_RNA; cl00611
568819004221	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
568819004222	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
568819004223	S-adenosylmethionine binding site [chemical binding]; other site
568819004224	chaperone protein DnaJ; Provisional; Region: PRK14280
568819004225	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257
568819004226	HSP70 interaction site [polypeptide binding]; other site
568819004227	DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908
568819004228	DnaJ C terminal domain; Region: DnaJ_C; pfam01556
568819004229	DnaJ C terminal domain; Region: DnaJ_C; pfam01556
568819004230	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
568819004231	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446
568819004232	dimer interface [polypeptide binding]; other site
568819004233	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
568819004234	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
568819004235	HrcA protein C terminal domain; Region: HrcA; pfam01628
568819004236	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
568819004237	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
568819004238	FeS/SAM binding site; other site
568819004239	HemN C-terminal region; Region: HemN_C; pfam06969
568819004240	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
568819004241	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
568819004242	NADP binding site [chemical binding]; other site
568819004243	putative substrate binding site [chemical binding]; other site
568819004244	active site
568819004245	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
568819004246	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
568819004247	DNA binding residues [nucleotide binding]
568819004248	putative dimer interface [polypeptide binding]; other site
568819004249	GTP-binding protein LepA; Provisional; Region: PRK05433
568819004250	LepA subfamily.  LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome.  LepA is ubiquitous in bacteria and...; Region: LepA; cd01890
568819004251	G1 box; other site
568819004252	putative GEF interaction site [polypeptide binding]; other site
568819004253	GTP/Mg2+ binding site [chemical binding]; other site
568819004254	Switch I region; other site
568819004255	G2 box; other site
568819004256	G3 box; other site
568819004257	Switch II region; other site
568819004258	G4 box; other site
568819004259	G5 box; other site
568819004260	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699
568819004261	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
568819004262	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
568819004263	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
568819004264	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
568819004265	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
568819004266	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
568819004267	Competence protein; Region: Competence; cl00471
568819004268	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
568819004269	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
568819004270	catalytic motif [active]
568819004271	Zn binding site [ion binding]; other site
568819004272	SLBB domain; Region: SLBB; pfam10531
568819004273	comEA protein; Region: comE; TIGR01259
568819004274	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
568819004275	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
568819004276	Domain of unknown function DUF143; Region: DUF143; cl00519
568819004277	Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713
568819004278	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
568819004279	Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057
568819004280	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
568819004281	active site
568819004282	(T/H)XGH motif; other site
568819004283	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663
568819004284	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
568819004285	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
568819004286	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
568819004287	shikimate binding site; other site
568819004288	NAD(P) binding site [chemical binding]; other site
568819004289	GTPase YqeH; Provisional; Region: PRK13796
568819004290	YqeH.  YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess initiation of DNA replication, suggesting that it negatively controls initiation of chromosome replication. The YqeH subfamily is common in eukaryotes and sporadically...; Region: YqeH; cd01855
568819004291	GTP/Mg2+ binding site [chemical binding]; other site
568819004292	G4 box; other site
568819004293	G5 box; other site
568819004294	G1 box; other site
568819004295	Switch I region; other site
568819004296	G2 box; other site
568819004297	G3 box; other site
568819004298	Switch II region; other site
568819004299	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
568819004300	motif II; other site
568819004301	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
568819004302	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607
568819004303	active site
568819004304	Zn binding site [ion binding]; other site
568819004305	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
568819004306	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Provisional; Region: PRK07164
568819004307	Protein of unknown function (DUF1510); Region: DUF1510; pfam07423
568819004308	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
568819004309	domain; Region: GreA_GreB_N; pfam03449
568819004310	C-term; Region: GreA_GreB; pfam01272
568819004311	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage...; Region: UMPK; cd02023
568819004312	Sugar specificity; other site
568819004313	Pyrimidine base specificity; other site
568819004314	ATP-binding site [chemical binding]; other site
568819004315	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
568819004316	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
568819004317	S-adenosylmethionine binding site [chemical binding]; other site
568819004318	YceG-like family; Region: YceG; pfam02618
568819004319	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
568819004320	dimerization interface [polypeptide binding]; other site
568819004321	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
568819004322	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
568819004323	Protein of unknown function (DUF1292); Region: DUF1292; cl01608
568819004324	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
568819004325	Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857
568819004326	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
568819004327	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673
568819004328	motif 1; other site
568819004329	active site
568819004330	motif 2; other site
568819004331	motif 3; other site
568819004332	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
568819004333	DHHA1 domain; Region: DHHA1; pfam02272
568819004334	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
568819004335	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
568819004336	Walker A/P-loop; other site
568819004337	ATP binding site [chemical binding]; other site
568819004338	Q-loop/lid; other site
568819004339	ABC transporter signature motif; other site
568819004340	Walker B; other site
568819004341	D-loop; other site
568819004342	H-loop/switch region; other site
568819004343	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
568819004344	FtsX-like permease family; Region: FtsX; pfam02687
568819004345	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568819004346	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
568819004347	active site
568819004348	phosphorylation site [posttranslational modification]
568819004349	intermolecular recognition site; other site
568819004350	dimerization interface [polypeptide binding]; other site
568819004351	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
568819004352	DNA binding site [nucleotide binding]
568819004353	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
568819004354	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
568819004355	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
568819004356	dimer interface [polypeptide binding]; other site
568819004357	phosphorylation site [posttranslational modification]
568819004358	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819004359	ATP binding site [chemical binding]; other site
568819004360	Mg2+ binding site [ion binding]; other site
568819004361	G-X-G motif; other site
568819004362	RecD/TraA family; Region: recD_rel; TIGR01448
568819004363	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819004364	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
568819004365	binding surface
568819004366	TPR motif; other site
568819004367	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
568819004368	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
568819004369	binding surface
568819004370	TPR motif; other site
568819004371	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
568819004372	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
568819004373	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998
568819004374	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
568819004375	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
568819004376	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
568819004377	catalytic residue [active]
568819004378	recombination factor protein RarA; Reviewed; Region: PRK13342
568819004379	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
568819004380	Walker A motif; other site
568819004381	ATP binding site [chemical binding]; other site
568819004382	Walker B motif; other site
568819004383	arginine finger; other site
568819004384	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
568819004385	Predicted transcriptional regulator [Transcription]; Region: COG1959
568819004386	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819004387	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
568819004388	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412
568819004389	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
568819004390	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
568819004391	dimer interface [polypeptide binding]; other site
568819004392	anticodon binding site; other site
568819004393	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
568819004394	homodimer interface [polypeptide binding]; other site
568819004395	motif 1; other site
568819004396	active site
568819004397	motif 2; other site
568819004398	GAD domain; Region: GAD; pfam02938
568819004399	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
568819004400	motif 3; other site
568819004401	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
568819004402	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
568819004403	dimer interface [polypeptide binding]; other site
568819004404	motif 1; other site
568819004405	active site
568819004406	motif 2; other site
568819004407	motif 3; other site
568819004408	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
568819004409	anticodon binding site; other site
568819004410	Bacterial SH3 domain; Region: SH3_3; cl02551
568819004411	Bacterial SH3 domain; Region: SH3_3; cl02551
568819004412	Bacterial SH3 domain; Region: SH3_3; cl02551
568819004413	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
568819004414	active site
568819004415	metal binding site [ion binding]; metal-binding site
568819004416	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563
568819004417	putative active site [active]
568819004418	dimerization interface [polypeptide binding]; other site
568819004419	putative tRNAtyr binding site [nucleotide binding]; other site
568819004420	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
568819004421	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
568819004422	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
568819004423	synthetase active site [active]
568819004424	NTP binding site [chemical binding]; other site
568819004425	metal binding site [ion binding]; metal-binding site
568819004426	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668
568819004427	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
568819004428	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
568819004429	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
568819004430	DHH family; Region: DHH; pfam01368
568819004431	DHHA1 domain; Region: DHHA1; pfam02272
568819004432	Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538
568819004433	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
568819004434	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
568819004435	Protein export membrane protein; Region: SecD_SecF; cl14618
568819004436	Protein export membrane protein; Region: SecD_SecF; cl14618
568819004437	Preprotein translocase subunit; Region: YajC; cl00806
568819004438	Queuine tRNA-ribosyltransferase; Region: TGT; cl00409
568819004439	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
568819004440	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
568819004441	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
568819004442	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
568819004443	Walker A motif; other site
568819004444	ATP binding site [chemical binding]; other site
568819004445	Walker B motif; other site
568819004446	arginine finger; other site
568819004447	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
568819004448	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
568819004449	RuvA N terminal domain; Region: RuvA_N; pfam01330
568819004450	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
568819004451	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
568819004452	tetramer (dimer of dimers) interface [polypeptide binding]; other site
568819004453	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
568819004454	NAD binding site [chemical binding]; other site
568819004455	dimer interface [polypeptide binding]; other site
568819004456	substrate binding site [chemical binding]; other site
568819004457	Domain of unknown function DUF28; Region: DUF28; cl00361
568819004458	prephenate dehydratase; Provisional; Region: PRK11898
568819004459	Prephenate dehydratase; Region: PDT; pfam00800
568819004460	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
568819004461	putative L-Phe binding site [chemical binding]; other site
568819004462	GTPase CgtA; Reviewed; Region: obgE; PRK12297
568819004463	GTP1/OBG; Region: GTP1_OBG; pfam01018
568819004464	Obg subfamily.  The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation.  Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898
568819004465	G1 box; other site
568819004466	GTP/Mg2+ binding site [chemical binding]; other site
568819004467	Switch I region; other site
568819004468	G2 box; other site
568819004469	G3 box; other site
568819004470	Switch II region; other site
568819004471	G4 box; other site
568819004472	G5 box; other site
568819004473	Domain of unknown function (DUF1967); Region: DUF1967; cl07779
568819004474	glycerol kinase; Provisional; Region: glpK; PRK00047
568819004475	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
568819004476	N- and C-terminal domain interface [polypeptide binding]; other site
568819004477	active site
568819004478	MgATP binding site [chemical binding]; other site
568819004479	catalytic site [active]
568819004480	metal binding site [ion binding]; metal-binding site
568819004481	glycerol binding site [chemical binding]; other site
568819004482	homotetramer interface [polypeptide binding]; other site
568819004483	homodimer interface [polypeptide binding]; other site
568819004484	FBP binding site [chemical binding]; other site
568819004485	protein IIAGlc interface [polypeptide binding]; other site
568819004486	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cd00333
568819004487	amphipathic channel; other site
568819004488	Asn-Pro-Ala signature motifs; other site
568819004489	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
568819004490	Protein of unknown function (DUF464); Region: DUF464; cl01080
568819004491	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
568819004492	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
568819004493	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
568819004494	homodimer interface [polypeptide binding]; other site
568819004495	oligonucleotide binding site [chemical binding]; other site
568819004496	septum site-determining protein MinD; Region: minD_bact; TIGR01968
568819004497	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a...; Region: MinD; cd02036
568819004498	Switch I; other site
568819004499	Switch II; other site
568819004500	septum formation inhibitor; Reviewed; Region: minC; PRK00513
568819004501	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
568819004502	rod shape-determining protein MreD; Region: MreD; cl01087
568819004503	rod shape-determining protein MreC; Provisional; Region: PRK13922
568819004504	rod shape-determining protein MreC; Region: MreC; pfam04085
568819004505	rod shape-determining protein MreB; Provisional; Region: PRK13927
568819004506	Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528
568819004507	ATP binding site [chemical binding]; other site
568819004508	profilin binding site; other site
568819004509	hypothetical protein; Reviewed; Region: PRK00024
568819004510	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
568819004511	MPN+ (JAMM) motif; other site
568819004512	Zinc-binding site [ion binding]; other site
568819004513	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
568819004514	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
568819004515	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
568819004516	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
568819004517	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
568819004518	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
568819004519	active site
568819004520	HIGH motif; other site
568819004521	nucleotide binding site [chemical binding]; other site
568819004522	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
568819004523	active site
568819004524	KMSKS motif; other site
568819004525	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
568819004526	tRNA binding surface [nucleotide binding]; other site
568819004527	anticodon binding site; other site
568819004528	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
568819004529	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
568819004530	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610
568819004531	inhibitor-cofactor binding pocket; inhibition site
568819004532	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819004533	catalytic residue [active]
568819004534	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
568819004535	dimer interface [polypeptide binding]; other site
568819004536	active site
568819004537	Schiff base residues; other site
568819004538	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
568819004539	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578
568819004540	active site
568819004541	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
568819004542	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
568819004543	domain interfaces; other site
568819004544	active site
568819004545	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
568819004546	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
568819004547	tRNA; other site
568819004548	putative tRNA binding site [nucleotide binding]; other site
568819004549	putative NADP binding site [chemical binding]; other site
568819004550	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
568819004551	The YihA (EngB) subfamily.  This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control.  YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876
568819004552	G1 box; other site
568819004553	GTP/Mg2+ binding site [chemical binding]; other site
568819004554	Switch I region; other site
568819004555	G2 box; other site
568819004556	G3 box; other site
568819004557	Switch II region; other site
568819004558	G4 box; other site
568819004559	G5 box; other site
568819004560	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
568819004561	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase...; Region: TGS_ThrRS_N; cd01667
568819004562	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
568819004563	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
568819004564	active site
568819004565	dimer interface [polypeptide binding]; other site
568819004566	motif 1; other site
568819004567	motif 2; other site
568819004568	motif 3; other site
568819004569	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
568819004570	anticodon binding site; other site
568819004571	primosomal protein DnaI; Reviewed; Region: PRK08939
568819004572	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
568819004573	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
568819004574	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
568819004575	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
568819004576	ATP cone domain; Region: ATP-cone; pfam03477
568819004577	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
568819004578	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
568819004579	CoA-binding site [chemical binding]; other site
568819004580	ATP-binding [chemical binding]; other site
568819004581	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
568819004582	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
568819004583	DNA binding site [nucleotide binding]
568819004584	catalytic residue [active]
568819004585	H2TH interface [polypeptide binding]; other site
568819004586	putative catalytic residues [active]
568819004587	turnover-facilitating residue; other site
568819004588	intercalation triad [nucleotide binding]; other site
568819004589	8OG recognition residue [nucleotide binding]; other site
568819004590	putative reading head residues; other site
568819004591	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
568819004592	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
568819004593	DNA polymerase I; Provisional; Region: PRK05755
568819004594	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
568819004595	active site
568819004596	metal binding site 1 [ion binding]; metal-binding site
568819004597	putative 5' ssDNA interaction site; other site
568819004598	metal binding site 3; metal-binding site
568819004599	metal binding site 2 [ion binding]; metal-binding site
568819004600	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
568819004601	putative DNA binding site [nucleotide binding]; other site
568819004602	putative metal binding site [ion binding]; other site
568819004603	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
568819004604	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
568819004605	active site
568819004606	DNA binding site [nucleotide binding]
568819004607	catalytic site [active]
568819004608	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
568819004609	isocitrate dehydrogenase; Validated; Region: PRK07362
568819004610	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes...; Region: BSuCS-II_like; cd06110
568819004611	dimer interface [polypeptide binding]; other site
568819004612	Citrate synthase; Region: Citrate_synt; pfam00285
568819004613	active site
568819004614	citrylCoA binding site [chemical binding]; other site
568819004615	oxalacetate/citrate binding site [chemical binding]; other site
568819004616	coenzyme A binding site [chemical binding]; other site
568819004617	catalytic triad [active]
568819004618	Protein of unknown function (DUF441); Region: DUF441; cl01041
568819004619	FxsA cytoplasmic membrane protein; Region: FxsA; cl01148
568819004620	pyruvate kinase; Provisional; Region: PRK06354
568819004621	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
568819004622	domain interfaces; other site
568819004623	active site
568819004624	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
568819004625	6-phosphofructokinase; Provisional; Region: PRK03202
568819004626	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
568819004627	active site
568819004628	ADP/pyrophosphate binding site [chemical binding]; other site
568819004629	dimerization interface [polypeptide binding]; other site
568819004630	allosteric effector site; other site
568819004631	fructose-1,6-bisphosphate binding site; other site
568819004632	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513
568819004633	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
568819004634	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
568819004635	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513
568819004636	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920
568819004637	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
568819004638	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
568819004639	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485
568819004640	generic binding surface I; other site
568819004641	generic binding surface II; other site
568819004642	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
568819004643	DHH family; Region: DHH; pfam01368
568819004644	DHHA1 domain; Region: DHHA1; pfam02272
568819004645	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
568819004646	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819004647	DNA-binding site [nucleotide binding]; DNA binding site
568819004648	DRTGG domain; Region: DRTGG; cl12147
568819004649	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
568819004650	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
568819004651	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
568819004652	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
568819004653	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
568819004654	active site
568819004655	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
568819004656	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222
568819004657	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819004658	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
568819004659	Ligand Binding Site [chemical binding]; other site
568819004660	Acetokinase family; Region: Acetate_kinase; cl01029
568819004661	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
568819004662	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
568819004663	S-adenosylmethionine binding site [chemical binding]; other site
568819004664	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
568819004665	dimer interface [polypeptide binding]; other site
568819004666	catalytic triad [active]
568819004667	peroxidatic and resolving cysteines [active]
568819004668	RDD family; Region: RDD; cl00746
568819004669	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
568819004670	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
568819004671	tandem repeat interface [polypeptide binding]; other site
568819004672	oligomer interface [polypeptide binding]; other site
568819004673	active site residues [active]
568819004674	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
568819004675	ornithine carbamoyltransferase; Provisional; Region: PRK00779
568819004676	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
568819004677	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819004678	acetylornithine aminotransferase; Provisional; Region: argD; PRK02936
568819004679	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610
568819004680	inhibitor-cofactor binding pocket; inhibition site
568819004681	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819004682	catalytic residue [active]
568819004683	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
568819004684	nucleotide binding site [chemical binding]; other site
568819004685	N-acetyl-L-glutamate binding site [chemical binding]; other site
568819004686	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152
568819004687	heterotetramer interface [polypeptide binding]; other site
568819004688	active site pocket [active]
568819004689	cleavage site
568819004690	N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
568819004691	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819004692	Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774
568819004693	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
568819004694	THUMP domain; Region: THUMP; cl12076
568819004695	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
568819004696	Ligand Binding Site [chemical binding]; other site
568819004697	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
568819004698	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
568819004699	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
568819004700	catalytic residue [active]
568819004701	Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477
568819004702	GAF domain; Region: GAF; cl00853
568819004703	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
568819004704	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
568819004705	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
568819004706	RNA binding surface [nucleotide binding]; other site
568819004707	tyrosyl-tRNA synthetase; Provisional; Region: PRK13354
568819004708	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
568819004709	active site
568819004710	HIGH motif; other site
568819004711	dimer interface [polypeptide binding]; other site
568819004712	KMSKS motif; other site
568819004713	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
568819004714	catabolite control protein A; Region: ccpA; TIGR01481
568819004715	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568819004716	DNA binding site [nucleotide binding]
568819004717	domain linker motif; other site
568819004718	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
568819004719	dimerization interface [polypeptide binding]; other site
568819004720	effector binding site; other site
568819004721	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
568819004722	Chorismate mutase type II; Region: CM_2; cl00693
568819004723	NeuB family; Region: NeuB; cl00496
568819004724	YtxH-like protein; Region: YtxH; cl02079
568819004725	Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972
568819004726	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
568819004727	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
568819004728	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015
568819004729	dimer interface [polypeptide binding]; other site
568819004730	decamer (pentamer of dimers) interface [polypeptide binding]; other site
568819004731	catalytic triad [active]
568819004732	peroxidatic and resolving cysteines [active]
568819004733	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
568819004734	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
568819004735	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
568819004736	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
568819004737	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
568819004738	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819004739	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
568819004740	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
568819004741	putative tRNA-binding site [nucleotide binding]; other site
568819004742	Protein of unknown function (DUF1444); Region: DUF1444; cl02011
568819004743	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
568819004744	catalytic residues [active]
568819004745	monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
568819004746	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
568819004747	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
568819004748	oligomer interface [polypeptide binding]; other site
568819004749	active site
568819004750	metal binding site [ion binding]; metal-binding site
568819004751	Predicted small secreted protein [Function unknown]; Region: COG5584
568819004752	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846
568819004753	putative homotetramer interface [polypeptide binding]; other site
568819004754	putative homodimer interface [polypeptide binding]; other site
568819004755	putative allosteric switch controlling residues; other site
568819004756	putative metal binding site [ion binding]; other site
568819004757	putative homodimer-homodimer interface [polypeptide binding]; other site
568819004758	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
568819004759	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
568819004760	Phosphotransferase enzyme family; Region: APH; pfam01636
568819004761	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
568819004762	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
568819004763	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819004764	putative substrate translocation pore; other site
568819004765	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819004766	Transcriptional regulators [Transcription]; Region: MarR; COG1846
568819004767	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819004768	branched-chain amino acid aminotransferase; Provisional; Region: PRK12479
568819004769	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-...; Region: D-AAT_like; cd01558
568819004770	homodimer interface [polypeptide binding]; other site
568819004771	substrate-cofactor binding pocket; other site
568819004772	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819004773	catalytic residue [active]
568819004774	dipeptidase PepV; Reviewed; Region: PRK07318
568819004775	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
568819004776	active site
568819004777	metal binding site [ion binding]; metal-binding site
568819004778	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699
568819004779	nudix motif; other site
568819004780	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
568819004781	putative substrate binding site [chemical binding]; other site
568819004782	putative ATP binding site [chemical binding]; other site
568819004783	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
568819004784	active site
568819004785	stage V sporulation protein B; Region: spore_V_B; TIGR02900
568819004786	MatE; Region: MatE; cl10513
568819004787	MatE; Region: MatE; cl10513
568819004788	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724
568819004789	tryptophan synthase; Region: PLN02591
568819004790	substrate binding site [chemical binding]; other site
568819004791	active site
568819004792	catalytic residues [active]
568819004793	heterodimer interface [polypeptide binding]; other site
568819004794	tryptophan synthase, beta chain; Region: PLN02618
568819004795	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
568819004796	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819004797	catalytic residue [active]
568819004798	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405
568819004799	active site
568819004800	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
568819004801	active site
568819004802	ribulose/triose binding site [chemical binding]; other site
568819004803	phosphate binding site [ion binding]; other site
568819004804	substrate (anthranilate) binding pocket [chemical binding]; other site
568819004805	product (indole) binding pocket [chemical binding]; other site
568819004806	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
568819004807	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
568819004808	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
568819004809	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
568819004810	Glutamine amidotransferase class-I; Region: GATase; pfam00117
568819004811	glutamine binding [chemical binding]; other site
568819004812	catalytic triad [active]
568819004813	anthranilate synthase component I; Provisional; Region: PRK13570
568819004814	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
568819004815	chorismate binding enzyme; Region: Chorismate_bind; cl10555
568819004816	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
568819004817	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
568819004818	putative catalytic cysteine [active]
568819004819	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
568819004820	putative active site [active]
568819004821	metal binding site [ion binding]; metal-binding site
568819004822	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
568819004823	dimer interface [polypeptide binding]; other site
568819004824	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
568819004825	The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance.  Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis.  The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268
568819004826	Walker A/P-loop; other site
568819004827	ATP binding site [chemical binding]; other site
568819004828	Q-loop/lid; other site
568819004829	ABC transporter signature motif; other site
568819004830	Walker B; other site
568819004831	D-loop; other site
568819004832	H-loop/switch region; other site
568819004833	ABC-2 type transporter; Region: ABC2_membrane; cl11417
568819004834	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
568819004835	putative dimer interface [polypeptide binding]; other site
568819004836	catalytic triad [active]
568819004837	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
568819004838	aconitate hydratase; Validated; Region: PRK09277
568819004839	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
568819004840	substrate binding site [chemical binding]; other site
568819004841	ligand binding site [chemical binding]; other site
568819004842	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
568819004843	substrate binding site [chemical binding]; other site
568819004844	Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
568819004845	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
568819004846	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
568819004847	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
568819004848	ATP binding site [chemical binding]; other site
568819004849	putative Mg++ binding site [ion binding]; other site
568819004850	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568819004851	nucleotide binding region [chemical binding]; other site
568819004852	ATP-binding site [chemical binding]; other site
568819004853	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
568819004854	SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279
568819004855	Walker A/P-loop; other site
568819004856	ATP binding site [chemical binding]; other site
568819004857	Q-loop/lid; other site
568819004858	SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279
568819004859	ABC transporter signature motif; other site
568819004860	Walker B; other site
568819004861	D-loop; other site
568819004862	H-loop/switch region; other site
568819004863	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
568819004864	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
568819004865	active site
568819004866	metal binding site [ion binding]; metal-binding site
568819004867	DNA binding site [nucleotide binding]
568819004868	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
568819004869	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
568819004870	putative acyl-acceptor binding pocket; other site
568819004871	Protein of unknown function (DUF1453); Region: DUF1453; cl02009
568819004872	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
568819004873	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
568819004874	Glucan exporter ATP-binding protein.  In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor.  This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254
568819004875	Walker A/P-loop; other site
568819004876	ATP binding site [chemical binding]; other site
568819004877	Q-loop/lid; other site
568819004878	ABC transporter signature motif; other site
568819004879	Walker B; other site
568819004880	D-loop; other site
568819004881	H-loop/switch region; other site
568819004882	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
568819004883	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
568819004884	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819004885	Walker A/P-loop; other site
568819004886	ATP binding site [chemical binding]; other site
568819004887	Q-loop/lid; other site
568819004888	ABC transporter signature motif; other site
568819004889	Walker B; other site
568819004890	D-loop; other site
568819004891	H-loop/switch region; other site
568819004892	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...; Region: ZnMc; cl00064
568819004893	active site
568819004894	VanZ like family; Region: VanZ; cl01971
568819004895	elongation factor Ts; Provisional; Region: tsf; PRK09377
568819004896	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
568819004897	Elongation factor TS; Region: EF_TS; pfam00889
568819004898	Elongation factor TS; Region: EF_TS; pfam00889
568819004899	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
568819004900	rRNA interaction site [nucleotide binding]; other site
568819004901	S8 interaction site; other site
568819004902	putative laminin-1 binding site; other site
568819004903	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212
568819004904	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
568819004905	active site turn [active]
568819004906	phosphorylation site [posttranslational modification]
568819004907	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
568819004908	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
568819004909	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
568819004910	putative active site [active]
568819004911	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
568819004912	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013
568819004913	putative active site [active]
568819004914	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
568819004915	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
568819004916	HIGH motif; other site
568819004917	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
568819004918	active site
568819004919	KMSKS motif; other site
568819004920	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
568819004921	tRNA binding surface [nucleotide binding]; other site
568819004922	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
568819004923	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
568819004924	FeS/SAM binding site; other site
568819004925	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
568819004926	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
568819004927	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
568819004928	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
568819004929	active site
568819004930	dimer interface [polypeptide binding]; other site
568819004931	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes...; Region: Asn_Synthase_B_C; cd01991
568819004932	Ligand Binding Site [chemical binding]; other site
568819004933	Molecular Tunnel; other site
568819004934	S-adenosylmethionine synthetase; Validated; Region: PRK05250
568819004935	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
568819004936	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
568819004937	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
568819004938	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
568819004939	tetramer (dimer of dimers) interface [polypeptide binding]; other site
568819004940	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
568819004941	NAD binding site [chemical binding]; other site
568819004942	dimer interface [polypeptide binding]; other site
568819004943	substrate binding site [chemical binding]; other site
568819004944	Protein of unknown function (DUF2584); Region: DUF2584; pfam10763
568819004945	nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705
568819004946	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
568819004947	nudix motif; other site
568819004948	Domain of unknown function DUF37; Region: DUF37; cl00506
568819004949	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
568819004950	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
568819004951	metal binding site [ion binding]; metal-binding site
568819004952	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640
568819004953	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
568819004954	dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396
568819004955	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
568819004956	substrate binding site [chemical binding]; other site
568819004957	oxyanion hole (OAH) forming residues; other site
568819004958	trimer interface [polypeptide binding]; other site
568819004959	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
568819004960	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
568819004961	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
568819004962	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
568819004963	dimer interface [polypeptide binding]; other site
568819004964	tetramer interface [polypeptide binding]; other site
568819004965	PYR/PP interface [polypeptide binding]; other site
568819004966	TPP binding site [chemical binding]; other site
568819004967	TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key role in the menaquinone biosynthetic pathway, converting...; Region: TPP_SHCHC_synthase; cd02009
568819004968	TPP-binding site; other site
568819004969	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
568819004970	chorismate binding enzyme; Region: Chorismate_bind; cl10555
568819004971	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; COG1575
568819004972	UbiA prenyltransferase family; Region: UbiA; cl00337
568819004973	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
568819004974	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105
568819004975	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537
568819004976	FAD binding site [chemical binding]; other site
568819004977	cystathionine beta-lyase; Provisional; Region: PRK08064
568819004978	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
568819004979	homodimer interface [polypeptide binding]; other site
568819004980	substrate-cofactor binding pocket; other site
568819004981	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819004982	catalytic residue [active]
568819004983	cystathionine gamma-synthase; Reviewed; Region: PRK08247
568819004984	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
568819004985	homodimer interface [polypeptide binding]; other site
568819004986	substrate-cofactor binding pocket; other site
568819004987	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819004988	catalytic residue [active]
568819004989	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
568819004990	N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_N_terminal_like; cd03312
568819004991	THF binding site; other site
568819004992	C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311
568819004993	substrate binding site [chemical binding]; other site
568819004994	THF binding site; other site
568819004995	zinc-binding site [ion binding]; other site
568819004996	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819004997	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568819004998	putative substrate translocation pore; other site
568819004999	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
568819005000	metal binding site 2 [ion binding]; metal-binding site
568819005001	putative DNA binding helix; other site
568819005002	metal binding site 1 [ion binding]; metal-binding site
568819005003	dimer interface [polypeptide binding]; other site
568819005004	structural Zn2+ binding site [ion binding]; other site
568819005005	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
568819005006	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819005007	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389
568819005008	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610
568819005009	inhibitor-cofactor binding pocket; inhibition site
568819005010	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819005011	catalytic residue [active]
568819005012	Predicted membrane protein [Function unknown]; Region: COG4129
568819005013	Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136
568819005014	Protein of unknown function (DUF402); Region: DUF402; cl00979
568819005015	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
568819005016	1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359
568819005017	putative NAD(P) binding site [chemical binding]; other site
568819005018	active site
568819005019	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
568819005020	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
568819005021	minor groove reading motif; other site
568819005022	helix-hairpin-helix signature motif; other site
568819005023	substrate binding pocket [chemical binding]; other site
568819005024	active site
568819005025	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
568819005026	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
568819005027	DNA binding and oxoG recognition site [nucleotide binding]
568819005028	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868
568819005029	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
568819005030	trimer interface [polypeptide binding]; other site
568819005031	active site
568819005032	RecX family; Region: RecX; cl00936
568819005033	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819005034	TIGR01777 family protein; Region: yfcH
568819005035	NAD(P) binding site [chemical binding]; other site
568819005036	active site
568819005037	Predicted integral membrane protein [Function unknown]; Region: COG0392
568819005038	Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219
568819005039	Uncharacterized conserved protein [Function unknown]; Region: COG2898
568819005040	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
568819005041	VanZ like family; Region: VanZ; cl01971
568819005042	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
568819005043	Cation efflux family; Region: Cation_efflux; cl00316
568819005044	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
568819005045	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
568819005046	PAS fold; Region: PAS_4; pfam08448
568819005047	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
568819005048	putative active site [active]
568819005049	heme pocket [chemical binding]; other site
568819005050	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
568819005051	FosX, a fosfomycin resistance protein, catalyzes the addition of a water molecule to the C1 position of the antibiotic with inversion of configuration at C1; Region: FosX; cd08364
568819005052	dimer interface [polypeptide binding]; other site
568819005053	active site
568819005054	Mn binding site [ion binding]; other site
568819005055	TRAM domain; Region: TRAM; cl01282
568819005056	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
568819005057	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
568819005058	S-adenosylmethionine binding site [chemical binding]; other site
568819005059	OsmC-like protein; Region: OsmC; cl00767
568819005060	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
568819005061	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7...; Region: dNK; cd01673
568819005062	Substrate-binding site [chemical binding]; other site
568819005063	Substrate specificity [chemical binding]; other site
568819005064	Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918
568819005065	Protein of unknown function (DUF1128); Region: DUF1128; cl11553
568819005066	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051
568819005067	methionine aminopeptidase; Reviewed; Region: PRK07281
568819005068	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
568819005069	active site
568819005070	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
568819005071	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
568819005072	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819005073	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568819005074	putative substrate translocation pore; other site
568819005075	rod-share determining protein MreBH; Provisional; Region: PRK13929
568819005076	Cell division protein FtsA; Region: FtsA; cl11496
568819005077	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
568819005078	S-adenosylmethionine binding site [chemical binding]; other site
568819005079	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568819005080	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568819005081	Uncharacterized conserved protein [Function unknown]; Region: COG4748
568819005082	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
568819005083	Uncharacterized conserved protein [Function unknown]; Region: COG3589
568819005084	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
568819005085	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
568819005086	methionine cluster; other site
568819005087	active site
568819005088	phosphorylation site [posttranslational modification]
568819005089	metal binding site [ion binding]; metal-binding site
568819005090	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564
568819005091	active site
568819005092	P-loop; other site
568819005093	phosphorylation site [posttranslational modification]
568819005094	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819005095	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
568819005096	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
568819005097	Walker A motif; other site
568819005098	ATP binding site [chemical binding]; other site
568819005099	Walker B motif; other site
568819005100	arginine finger; other site
568819005101	Transcriptional antiterminator [Transcription]; Region: COG3933
568819005102	PRD domain; Region: PRD; pfam00874
568819005103	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006
568819005104	active pocket/dimerization site; other site
568819005105	active site
568819005106	phosphorylation site [posttranslational modification]
568819005107	PRD domain; Region: PRD; pfam00874
568819005108	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819005109	DEAD-like helicases superfamily; Region: DEXDc; smart00487
568819005110	ATP binding site [chemical binding]; other site
568819005111	putative Mg++ binding site [ion binding]; other site
568819005112	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568819005113	nucleotide binding region [chemical binding]; other site
568819005114	ATP-binding site [chemical binding]; other site
568819005115	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
568819005116	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
568819005117	Walker A/P-loop; other site
568819005118	ATP binding site [chemical binding]; other site
568819005119	Q-loop/lid; other site
568819005120	ABC transporter signature motif; other site
568819005121	Walker B; other site
568819005122	D-loop; other site
568819005123	H-loop/switch region; other site
568819005124	Predicted transcriptional regulators [Transcription]; Region: COG1725
568819005125	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819005126	DNA-binding site [nucleotide binding]; DNA binding site
568819005127	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
568819005128	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819005129	Transcriptional regulators [Transcription]; Region: PurR; COG1609
568819005130	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568819005131	DNA binding site [nucleotide binding]
568819005132	domain linker motif; other site
568819005133	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
568819005134	dimerization interface [polypeptide binding]; other site
568819005135	ligand binding site [chemical binding]; other site
568819005136	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
568819005137	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
568819005138	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
568819005139	Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915
568819005140	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
568819005141	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
568819005142	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819005143	dimer interface [polypeptide binding]; other site
568819005144	conserved gate region; other site
568819005145	putative PBP binding loops; other site
568819005146	ABC-ATPase subunit interface; other site
568819005147	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
568819005148	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819005149	dimer interface [polypeptide binding]; other site
568819005150	conserved gate region; other site
568819005151	putative PBP binding loops; other site
568819005152	ABC-ATPase subunit interface; other site
568819005153	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
568819005154	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819005155	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
568819005156	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713
568819005157	active site
568819005158	dimer interface [polypeptide binding]; other site
568819005159	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
568819005160	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808
568819005161	active site
568819005162	FMN binding site [chemical binding]; other site
568819005163	substrate binding site [chemical binding]; other site
568819005164	3Fe-4S cluster binding site [ion binding]; other site
568819005165	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
568819005166	domain interface; other site
568819005167	Transcriptional regulator [Transcription]; Region: LysR; COG0583
568819005168	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819005169	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
568819005170	putative dimerization interface [polypeptide binding]; other site
568819005171	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
568819005172	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
568819005173	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
568819005174	putative active site [active]
568819005175	metal binding site [ion binding]; metal-binding site
568819005176	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
568819005177	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
568819005178	substrate binding pocket [chemical binding]; other site
568819005179	membrane-bound complex binding site; other site
568819005180	hinge residues; other site
568819005181	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
568819005182	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819005183	Walker A/P-loop; other site
568819005184	ATP binding site [chemical binding]; other site
568819005185	Q-loop/lid; other site
568819005186	ABC transporter signature motif; other site
568819005187	Walker B; other site
568819005188	D-loop; other site
568819005189	H-loop/switch region; other site
568819005190	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819005191	dimer interface [polypeptide binding]; other site
568819005192	conserved gate region; other site
568819005193	putative PBP binding loops; other site
568819005194	ABC-ATPase subunit interface; other site
568819005195	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080
568819005196	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819005197	ATP binding site [chemical binding]; other site
568819005198	Mg2+ binding site [ion binding]; other site
568819005199	G-X-G motif; other site
568819005200	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
568819005201	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
568819005202	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen...; Region: AdeC; cd01295
568819005203	active site
568819005204	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
568819005205	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
568819005206	putative NAD(P) binding site [chemical binding]; other site
568819005207	active site
568819005208	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568819005209	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
568819005210	active site
568819005211	phosphorylation site [posttranslational modification]
568819005212	intermolecular recognition site; other site
568819005213	dimerization interface [polypeptide binding]; other site
568819005214	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
568819005215	DNA binding site [nucleotide binding]
568819005216	FtsX-like permease family; Region: FtsX; pfam02687
568819005217	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
568819005218	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
568819005219	Walker A/P-loop; other site
568819005220	ATP binding site [chemical binding]; other site
568819005221	Q-loop/lid; other site
568819005222	ABC transporter signature motif; other site
568819005223	Walker B; other site
568819005224	D-loop; other site
568819005225	H-loop/switch region; other site
568819005226	shikimate kinase; Reviewed; Region: aroK; PRK00131
568819005227	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464
568819005228	ADP binding site [chemical binding]; other site
568819005229	magnesium binding site [ion binding]; other site
568819005230	putative shikimate binding site; other site
568819005231	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884
568819005232	TRAM domain; Region: TRAM; cl01282
568819005233	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
568819005234	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
568819005235	putative lipid kinase; Reviewed; Region: PRK13337
568819005236	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
568819005237	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
568819005238	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
568819005239	GatB domain; Region: GatB_Yqey; cl11497
568819005240	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
568819005241	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
568819005242	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
568819005243	CamS sex pheromone cAM373 precursor; Region: CamS; cl11554
568819005244	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
568819005245	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
568819005246	nucleotide binding pocket [chemical binding]; other site
568819005247	K-X-D-G motif; other site
568819005248	catalytic site [active]
568819005249	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
568819005250	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027
568819005251	Dimer interface [polypeptide binding]; other site
568819005252	BRCT sequence motif; other site
568819005253	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
568819005254	UvrD/REP helicase; Region: UvrD-helicase; cl14126
568819005255	Predicted phosphate-binding enzymes, TIM-barrel fold [General function prediction only]; Region: COG1646
568819005256	PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between sn-glycerol-1-...; Region: PcrB_like; cd02812
568819005257	substrate binding site [chemical binding]; other site
568819005258	putative active site [active]
568819005259	dimer interface [polypeptide binding]; other site
568819005260	Sodium:neurotransmitter symporter family; Region: SNF; cl11976
568819005261	Trp repressor protein; Region: Trp_repressor; cl01121
568819005262	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
568819005263	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
568819005264	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
568819005265	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
568819005266	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
568819005267	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421
568819005268	purine monophosphate binding site [chemical binding]; other site
568819005269	dimer interface [polypeptide binding]; other site
568819005270	putative catalytic residues [active]
568819005271	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
568819005272	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
568819005273	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
568819005274	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
568819005275	active site
568819005276	substrate binding site [chemical binding]; other site
568819005277	cosubstrate binding site; other site
568819005278	catalytic site [active]
568819005279	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
568819005280	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196
568819005281	dimerization interface [polypeptide binding]; other site
568819005282	putative ATP binding site [chemical binding]; other site
568819005283	amidophosphoribosyltransferase; Provisional; Region: PRK06781
568819005284	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
568819005285	active site
568819005286	tetramer interface [polypeptide binding]; other site
568819005287	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
568819005288	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
568819005289	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203
568819005290	dimerization interface [polypeptide binding]; other site
568819005291	ATP binding site [chemical binding]; other site
568819005292	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204
568819005293	dimerization interface [polypeptide binding]; other site
568819005294	ATP binding site [chemical binding]; other site
568819005295	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
568819005296	putative active site [active]
568819005297	catalytic triad [active]
568819005298	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789
568819005299	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
568819005300	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
568819005301	ATP binding site [chemical binding]; other site
568819005302	active site
568819005303	substrate binding site [chemical binding]; other site
568819005304	adenylosuccinate lyase; Provisional; Region: PRK07492
568819005305	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
568819005306	tetramer interface [polypeptide binding]; other site
568819005307	active site
568819005308	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819005309	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
568819005310	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
568819005311	AIR carboxylase; Region: AIRC; cl00310
568819005312	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498
568819005313	hypothetical protein; Provisional; Region: PRK04164
568819005314	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
568819005315	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
568819005316	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
568819005317	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This...; Region: ABC_cobalt_CbiO_domain1; cd03225
568819005318	Walker A/P-loop; other site
568819005319	ATP binding site [chemical binding]; other site
568819005320	Q-loop/lid; other site
568819005321	ABC transporter signature motif; other site
568819005322	Walker B; other site
568819005323	D-loop; other site
568819005324	H-loop/switch region; other site
568819005325	peptidase T; Region: peptidase-T; TIGR01882
568819005326	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
568819005327	metal binding site [ion binding]; metal-binding site
568819005328	dimer interface [polypeptide binding]; other site
568819005329	Protein of unknown function (DUF1697); Region: DUF1697; cl01557
568819005330	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
568819005331	active site
568819005332	DNA binding site [nucleotide binding]
568819005333	putative phosphate binding site [ion binding]; other site
568819005334	putative catalytic site [active]
568819005335	metal binding site A [ion binding]; metal-binding site
568819005336	AP binding site [nucleotide binding]; other site
568819005337	metal binding site B [ion binding]; metal-binding site
568819005338	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
568819005339	23S rRNA binding site [nucleotide binding]; other site
568819005340	L21 binding site [polypeptide binding]; other site
568819005341	L13 binding site [polypeptide binding]; other site
568819005342	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
568819005343	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
568819005344	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
568819005345	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
568819005346	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
568819005347	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819005348	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309
568819005349	Substrate binding site [chemical binding]; other site
568819005350	LRR adjacent; Region: LRR_adjacent; pfam08191
568819005351	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
568819005352	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
568819005353	DNA binding residues [nucleotide binding]
568819005354	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
568819005355	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
568819005356	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
568819005357	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
568819005358	RimM N-terminal domain; Region: RimM; pfam01782
568819005359	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959
568819005360	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
568819005361	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
568819005362	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
568819005363	catalytic triad [active]
568819005364	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794
568819005365	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
568819005366	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053
568819005367	signal recognition particle protein; Provisional; Region: PRK10867
568819005368	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
568819005369	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
568819005370	P loop; other site
568819005371	GTP binding site [chemical binding]; other site
568819005372	Signal peptide binding domain; Region: SRP_SPB; pfam02978
568819005373	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
568819005374	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
568819005375	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
568819005376	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
568819005377	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
568819005378	P loop; other site
568819005379	GTP binding site [chemical binding]; other site
568819005380	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
568819005381	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278
568819005382	Walker A/P-loop; other site
568819005383	ATP binding site [chemical binding]; other site
568819005384	Q-loop/lid; other site
568819005385	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
568819005386	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278
568819005387	ABC transporter signature motif; other site
568819005388	Walker B; other site
568819005389	D-loop; other site
568819005390	H-loop/switch region; other site
568819005391	ribonuclease III; Reviewed; Region: rnc; PRK00102
568819005392	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593
568819005393	dimerization interface [polypeptide binding]; other site
568819005394	active site
568819005395	metal binding site [ion binding]; metal-binding site
568819005396	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048
568819005397	dsRNA binding site [nucleotide binding]; other site
568819005398	Phosphopantetheine attachment site; Region: PP-binding; cl09936
568819005399	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
568819005400	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
568819005401	NAD(P) binding site [chemical binding]; other site
568819005402	homotetramer interface [polypeptide binding]; other site
568819005403	homodimer interface [polypeptide binding]; other site
568819005404	active site
568819005405	Acyl transferase domain; Region: Acyl_transf_1; cl08282
568819005406	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
568819005407	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
568819005408	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
568819005409	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
568819005410	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
568819005411	Y-family of DNA polymerases; Region: PolY; cl12025
568819005412	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488
568819005413	generic binding surface II; other site
568819005414	ssDNA binding site; other site
568819005415	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
568819005416	ATP binding site [chemical binding]; other site
568819005417	putative Mg++ binding site [ion binding]; other site
568819005418	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568819005419	nucleotide binding region [chemical binding]; other site
568819005420	ATP-binding site [chemical binding]; other site
568819005421	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
568819005422	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
568819005423	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
568819005424	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
568819005425	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
568819005426	putative L-serine binding site [chemical binding]; other site
568819005427	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
568819005428	DAK2 domain; Region: Dak2; cl03685
568819005429	Protein of unknown function (DUF322); Region: DUF322; cl00574
568819005430	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
568819005431	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
568819005432	Thiamine pyrophosphokinase; Region: TPK; cd07995
568819005433	active site
568819005434	dimerization interface [polypeptide binding]; other site
568819005435	thiamine binding site [chemical binding]; other site
568819005436	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429
568819005437	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
568819005438	substrate binding site [chemical binding]; other site
568819005439	hexamer interface [polypeptide binding]; other site
568819005440	metal binding site [ion binding]; metal-binding site
568819005441	GTPase RsgA; Reviewed; Region: PRK00098
568819005442	YjeQ/EngC.  YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854
568819005443	GTPase/OB domain interface [polypeptide binding]; other site
568819005444	GTPase/Zn-binding domain interface [polypeptide binding]; other site
568819005445	GTP/Mg2+ binding site [chemical binding]; other site
568819005446	G4 box; other site
568819005447	G1 box; other site
568819005448	Switch I region; other site
568819005449	G2 box; other site
568819005450	G3 box; other site
568819005451	Switch II region; other site
568819005452	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
568819005453	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
568819005454	active site
568819005455	ATP binding site [chemical binding]; other site
568819005456	substrate binding site [chemical binding]; other site
568819005457	activation loop (A-loop); other site
568819005458	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
568819005459	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577
568819005460	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577
568819005461	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577
568819005462	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
568819005463	Protein phosphatase 2C; Region: PP2C; pfam00481
568819005464	Active site [active]
568819005465	16S rRNA methyltransferase B; Provisional; Region: PRK14902
568819005466	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223
568819005467	putative RNA binding site [nucleotide binding]; other site
568819005468	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
568819005469	S-adenosylmethionine binding site [chemical binding]; other site
568819005470	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
568819005471	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
568819005472	putative active site [active]
568819005473	substrate binding site [chemical binding]; other site
568819005474	putative cosubstrate binding site; other site
568819005475	catalytic site [active]
568819005476	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
568819005477	substrate binding site [chemical binding]; other site
568819005478	primosome assembly protein PriA; Validated; Region: PRK05580
568819005479	primosome assembly protein PriA; Validated; Region: PRK05580
568819005480	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
568819005481	ATP binding site [chemical binding]; other site
568819005482	putative Mg++ binding site [ion binding]; other site
568819005483	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819005484	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
568819005485	Flavoprotein; Region: Flavoprotein; cl08021
568819005486	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
568819005487	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
568819005488	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071
568819005489	catalytic site [active]
568819005490	G-X2-G-X-G-K; other site
568819005491	hypothetical protein; Provisional; Region: PRK11820
568819005492	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
568819005493	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
568819005494	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
568819005495	Domain of unknown function (DUF814); Region: DUF814; pfam05670
568819005496	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819005497	NAD(P) binding site [chemical binding]; other site
568819005498	active site
568819005499	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
568819005500	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
568819005501	active site
568819005502	dimer interface [polypeptide binding]; other site
568819005503	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
568819005504	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
568819005505	heterodimer interface [polypeptide binding]; other site
568819005506	active site
568819005507	FMN binding site [chemical binding]; other site
568819005508	homodimer interface [polypeptide binding]; other site
568819005509	substrate binding site [chemical binding]; other site
568819005510	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
568819005511	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
568819005512	FAD binding pocket [chemical binding]; other site
568819005513	FAD binding motif [chemical binding]; other site
568819005514	phosphate binding motif [ion binding]; other site
568819005515	beta-alpha-beta structure motif; other site
568819005516	NAD binding pocket [chemical binding]; other site
568819005517	Iron coordination center [ion binding]; other site
568819005518	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
568819005519	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
568819005520	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
568819005521	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
568819005522	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
568819005523	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
568819005524	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
568819005525	IMP binding site; other site
568819005526	dimer interface [polypeptide binding]; other site
568819005527	interdomain contacts; other site
568819005528	partial ornithine binding site; other site
568819005529	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
568819005530	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
568819005531	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
568819005532	catalytic site [active]
568819005533	subunit interface [polypeptide binding]; other site
568819005534	dihydroorotase; Validated; Region: pyrC; PRK09357
568819005535	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
568819005536	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317
568819005537	active site
568819005538	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
568819005539	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
568819005540	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819005541	Sulfate transporter family; Region: Sulfate_transp; cl00967
568819005542	Permease family; Region: Xan_ur_permease; pfam00860
568819005543	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
568819005544	Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
568819005545	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
568819005546	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
568819005547	RNA binding surface [nucleotide binding]; other site
568819005548	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
568819005549	active site
568819005550	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
568819005551	Sulfate transporter family; Region: Sulfate_transp; cl00967
568819005552	Permease family; Region: Xan_ur_permease; pfam00860
568819005553	multidrug efflux protein; Reviewed; Region: PRK01766
568819005554	MatE; Region: MatE; cl10513
568819005555	MatE; Region: MatE; cl10513
568819005556	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
568819005557	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
568819005558	metal binding site [ion binding]; metal-binding site
568819005559	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
568819005560	ABC-ATPase subunit  interface; other site
568819005561	dimer interface [polypeptide binding]; other site
568819005562	putative PBP binding regions; other site
568819005563	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
568819005564	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235
568819005565	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819005566	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
568819005567	C-terminal peptidase (prc); Region: prc; TIGR00225
568819005568	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
568819005569	protein binding site [polypeptide binding]; other site
568819005570	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
568819005571	Catalytic dyad [active]
568819005572	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
568819005573	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
568819005574	metal-binding site [ion binding]
568819005575	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
568819005576	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
568819005577	metal-binding site [ion binding]
568819005578	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
568819005579	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
568819005580	motif II; other site
568819005581	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846
568819005582	putative homotetramer interface [polypeptide binding]; other site
568819005583	putative homodimer interface [polypeptide binding]; other site
568819005584	putative allosteric switch controlling residues; other site
568819005585	putative metal binding site [ion binding]; other site
568819005586	putative homodimer-homodimer interface [polypeptide binding]; other site
568819005587	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
568819005588	D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813
568819005589	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
568819005590	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
568819005591	Protein of unknown function (DUF1250); Region: DUF1250; cl11485
568819005592	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
568819005593	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819005594	SelR domain; Region: SelR; cl00369
568819005595	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
568819005596	Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548
568819005597	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
568819005598	active site
568819005599	catalytic triad [active]
568819005600	oxyanion hole [active]
568819005601	Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577
568819005602	Haemolysin-III related; Region: HlyIII; cl03831
568819005603	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819005604	FOG: CBS domain [General function prediction only]; Region: COG0517
568819005605	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_4; cd04617
568819005606	Domain of unknown function (DUF299); Region: DUF299; cl00780
568819005607	pyruvate phosphate dikinase; Provisional; Region: PRK09279
568819005608	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
568819005609	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
568819005610	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
568819005611	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
568819005612	Predicted membrane protein [Function unknown]; Region: COG4129
568819005613	Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136
568819005614	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
568819005615	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
568819005616	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
568819005617	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149
568819005618	Clostridial hydrophobic W; Region: ChW; cl02763
568819005619	Clostridial hydrophobic W; Region: ChW; cl02763
568819005620	Clostridial hydrophobic W; Region: ChW; cl02763
568819005621	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
568819005622	active site
568819005623	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
568819005624	substrate binding site [chemical binding]; other site
568819005625	metal binding site [ion binding]; metal-binding site
568819005626	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
568819005627	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
568819005628	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209
568819005629	folate binding site [chemical binding]; other site
568819005630	NADP+ binding site [chemical binding]; other site
568819005631	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
568819005632	dimerization interface [polypeptide binding]; other site
568819005633	active site
568819005634	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
568819005635	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This...; Region: ABC_cobalt_CbiO_domain1; cd03225
568819005636	Walker A/P-loop; other site
568819005637	ATP binding site [chemical binding]; other site
568819005638	Q-loop/lid; other site
568819005639	ABC transporter signature motif; other site
568819005640	Walker B; other site
568819005641	D-loop; other site
568819005642	H-loop/switch region; other site
568819005643	ABC transporter; Region: ABC_tran_2; pfam12848
568819005644	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
568819005645	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
568819005646	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
568819005647	Potassium binding sites [ion binding]; other site
568819005648	Cesium cation binding sites [ion binding]; other site
568819005649	manganese transport transcriptional regulator; Provisional; Region: PRK03902
568819005650	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819005651	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
568819005652	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458
568819005653	DNA-binding site [nucleotide binding]; DNA binding site
568819005654	RNA-binding motif; other site
568819005655	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
568819005656	RNA/DNA hybrid binding site [nucleotide binding]; other site
568819005657	active site
568819005658	5'-3' exonuclease; Region: 53EXOc; smart00475
568819005659	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
568819005660	active site
568819005661	metal binding site 1 [ion binding]; metal-binding site
568819005662	putative 5' ssDNA interaction site; other site
568819005663	metal binding site 3; metal-binding site
568819005664	metal binding site 2 [ion binding]; metal-binding site
568819005665	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
568819005666	putative DNA binding site [nucleotide binding]; other site
568819005667	putative metal binding site [ion binding]; other site
568819005668	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
568819005669	GH18 domain of Chitinase D (ChiD).  ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins.  The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18 (...; Region: GH18_chitinase_D-like; cd02871
568819005670	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
568819005671	putative active site [active]
568819005672	Permease family; Region: Xan_ur_permease; pfam00860
568819005673	Sulfate transporter family; Region: Sulfate_transp; cl00967
568819005674	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
568819005675	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
568819005676	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
568819005677	active site
568819005678	Zn binding site [ion binding]; other site
568819005679	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
568819005680	THUMP domain; Region: THUMP; cl12076
568819005681	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
568819005682	cell division protein GpsB; Provisional; Region: PRK14127
568819005683	DivIVA domain; Region: DivI1A_domain; TIGR03544
568819005684	Interactor of ZYG-11; Region: ZYG-11_interact; pfam05884
568819005685	Protein of unknown function (DUF1273); Region: DUF1273; cl01859
568819005686	Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807
568819005687	Recombination protein U; Region: RecU; cl01314
568819005688	Transglycosylase; Region: Transgly; cl07896
568819005689	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
568819005690	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
568819005691	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
568819005692	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
568819005693	minor groove reading motif; other site
568819005694	helix-hairpin-helix signature motif; other site
568819005695	substrate binding pocket [chemical binding]; other site
568819005696	active site
568819005697	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
568819005698	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
568819005699	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
568819005700	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
568819005701	putative dimer interface [polypeptide binding]; other site
568819005702	putative anticodon binding site; other site
568819005703	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well...; Region: AsxRS_core; cd00776
568819005704	homodimer interface [polypeptide binding]; other site
568819005705	motif 1; other site
568819005706	motif 2; other site
568819005707	active site
568819005708	motif 3; other site
568819005709	hypothetical protein; Validated; Region: PRK07682
568819005710	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
568819005711	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819005712	homodimer interface [polypeptide binding]; other site
568819005713	catalytic residue [active]
568819005714	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
568819005715	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
568819005716	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
568819005717	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
568819005718	active site
568819005719	substrate binding site [chemical binding]; other site
568819005720	catalytic site [active]
568819005721	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819005722	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819005723	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
568819005724	tetramerization interface [polypeptide binding]; other site
568819005725	active site
568819005726	pantoate--beta-alanine ligase; Region: panC; TIGR00018
568819005727	Pantoate-beta-alanine ligase; Region: PanC; cd00560
568819005728	active site
568819005729	ATP-binding site [chemical binding]; other site
568819005730	pantoate-binding site; other site
568819005731	HXXH motif; other site
568819005732	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
568819005733	active site
568819005734	oligomerization interface [polypeptide binding]; other site
568819005735	metal binding site [ion binding]; metal-binding site
568819005736	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
568819005737	catalytic residues [active]
568819005738	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819005739	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
568819005740	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
568819005741	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
568819005742	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
568819005743	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
568819005744	active site
568819005745	NTP binding site [chemical binding]; other site
568819005746	metal binding triad [ion binding]; metal-binding site
568819005747	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
568819005748	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
568819005749	active site
568819005750	dimer interfaces [polypeptide binding]; other site
568819005751	catalytic residues [active]
568819005752	dihydrodipicolinate reductase; Provisional; Region: PRK00048
568819005753	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819005754	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
568819005755	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
568819005756	Uncharacterized conserved protein [Function unknown]; Region: COG1284
568819005757	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
568819005758	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
568819005759	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498
568819005760	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
568819005761	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881
568819005762	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
568819005763	metal binding site [ion binding]; metal-binding site
568819005764	active site
568819005765	I-site; other site
568819005766	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
568819005767	metal binding site [ion binding]; metal-binding site
568819005768	active site
568819005769	I-site; other site
568819005770	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
568819005771	malate dehydrogenase; Provisional; Region: PRK13529
568819005772	Malic enzyme, N-terminal domain; Region: malic; pfam00390
568819005773	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819005774	NAD(P) binding pocket [chemical binding]; other site
568819005775	Beta-lactamase; Region: Beta-lactamase; cl01009
568819005776	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
568819005777	Pyruvate formate lyase 1; Region: PFL1; cd01678
568819005778	coenzyme A binding site [chemical binding]; other site
568819005779	active site
568819005780	catalytic residues [active]
568819005781	glycine loop; other site
568819005782	Predicted flavoproteins [General function prediction only]; Region: COG2081
568819005783	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819005784	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049
568819005785	Protein of unknown function (DUF1405); Region: DUF1405; cl01798
568819005786	hypothetical protein; Provisional; Region: PRK03636
568819005787	UPF0302 domain; Region: UPF0302; pfam08864
568819005788	IDEAL domain; Region: IDEAL; cl07452
568819005789	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
568819005790	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
568819005791	binding surface
568819005792	TPR motif; other site
568819005793	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
568819005794	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556
568819005795	hinge; other site
568819005796	active site
568819005797	prephenate dehydrogenase; Validated; Region: PRK06545
568819005798	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819005799	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
568819005800	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
568819005801	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
568819005802	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819005803	homodimer interface [polypeptide binding]; other site
568819005804	catalytic residue [active]
568819005805	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In...; Region: AroH; cd02185
568819005806	homotrimer interaction site [polypeptide binding]; other site
568819005807	active site
568819005808	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
568819005809	active site
568819005810	dimer interface [polypeptide binding]; other site
568819005811	metal binding site [ion binding]; metal-binding site
568819005812	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
568819005813	Tetramer interface [polypeptide binding]; other site
568819005814	Active site [active]
568819005815	FMN-binding site [chemical binding]; other site
568819005816	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
568819005817	active site
568819005818	multimer interface [polypeptide binding]; other site
568819005819	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
568819005820	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
568819005821	substrate binding pocket [chemical binding]; other site
568819005822	chain length determination region; other site
568819005823	substrate-Mg2+ binding site; other site
568819005824	catalytic residues [active]
568819005825	aspartate-rich region 1; other site
568819005826	active site lid residues [active]
568819005827	aspartate-rich region 2; other site
568819005828	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
568819005829	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
568819005830	S-adenosylmethionine binding site [chemical binding]; other site
568819005831	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307
568819005832	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
568819005833	homodecamer interface [polypeptide binding]; other site
568819005834	GTP cyclohydrolase I; Provisional; Region: PLN03044
568819005835	active site
568819005836	putative catalytic site residues [active]
568819005837	zinc binding site [ion binding]; other site
568819005838	GTP-CH-I/GFRP interaction surface; other site
568819005839	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591
568819005840	IHF dimer interface [polypeptide binding]; other site
568819005841	IHF - DNA interface [nucleotide binding]; other site
568819005842	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053
568819005843	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
568819005844	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819005845	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
568819005846	GTP-binding protein Der; Reviewed; Region: PRK00093
568819005847	EngA1 subfamily.  This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains.  Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894
568819005848	G1 box; other site
568819005849	GTP/Mg2+ binding site [chemical binding]; other site
568819005850	Switch I region; other site
568819005851	G2 box; other site
568819005852	Switch II region; other site
568819005853	G3 box; other site
568819005854	G4 box; other site
568819005855	G5 box; other site
568819005856	EngA2 subfamily.  This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains.  Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895
568819005857	G1 box; other site
568819005858	GTP/Mg2+ binding site [chemical binding]; other site
568819005859	Switch I region; other site
568819005860	G2 box; other site
568819005861	G3 box; other site
568819005862	Switch II region; other site
568819005863	G4 box; other site
568819005864	G5 box; other site
568819005865	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
568819005866	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
568819005867	RNA binding site [nucleotide binding]; other site
568819005868	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
568819005869	RNA binding site [nucleotide binding]; other site
568819005870	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688
568819005871	RNA binding site [nucleotide binding]; other site
568819005872	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692
568819005873	RNA binding site [nucleotide binding]; other site
568819005874	cytidylate kinase; Provisional; Region: cmk; PRK00023
568819005875	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
568819005876	CMP-binding site; other site
568819005877	The sites determining sugar specificity; other site
568819005878	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
568819005879	active site
568819005880	homotetramer interface [polypeptide binding]; other site
568819005881	homodimer interface [polypeptide binding]; other site
568819005882	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
568819005883	putative peptidoglycan binding site; other site
568819005884	DEAD-like helicases superfamily; Region: DEXDc; smart00487
568819005885	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
568819005886	ATP binding site [chemical binding]; other site
568819005887	putative Mg++ binding site [ion binding]; other site
568819005888	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568819005889	nucleotide binding region [chemical binding]; other site
568819005890	ATP-binding site [chemical binding]; other site
568819005891	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
568819005892	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
568819005893	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568819005894	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568819005895	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568819005896	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568819005897	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568819005898	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568819005899	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568819005900	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
568819005901	Protein of unknown function (DUF1393); Region: DUF1393; cl01942
568819005902	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
568819005903	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442
568819005904	proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785
568819005905	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
568819005906	dimerization interface [polypeptide binding]; other site
568819005907	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
568819005908	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
568819005909	dimer interface [polypeptide binding]; other site
568819005910	phosphorylation site [posttranslational modification]
568819005911	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819005912	ATP binding site [chemical binding]; other site
568819005913	Mg2+ binding site [ion binding]; other site
568819005914	G-X-G motif; other site
568819005915	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568819005916	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
568819005917	active site
568819005918	phosphorylation site [posttranslational modification]
568819005919	intermolecular recognition site; other site
568819005920	dimerization interface [polypeptide binding]; other site
568819005921	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
568819005922	DNA binding site [nucleotide binding]
568819005923	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
568819005924	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
568819005925	RNA binding surface [nucleotide binding]; other site
568819005926	Pseudouridine synthases  are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870
568819005927	active site
568819005928	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
568819005929	ScpA/B protein; Region: ScpA_ScpB; cl00598
568819005930	diaminopimelate decarboxylase; Region: lysA; TIGR01048
568819005931	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
568819005932	active site
568819005933	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
568819005934	substrate binding site [chemical binding]; other site
568819005935	catalytic residues [active]
568819005936	dimer interface [polypeptide binding]; other site
568819005937	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
568819005938	Sulfatase; Region: Sulfatase; cl10460
568819005939	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
568819005940	N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid...; Region: INT_XerDC; cd00798
568819005941	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
568819005942	Int/Topo IB signature motif; other site
568819005943	active site
568819005944	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
568819005945	metal binding site 2 [ion binding]; metal-binding site
568819005946	putative DNA binding helix; other site
568819005947	metal binding site 1 [ion binding]; metal-binding site
568819005948	dimer interface [polypeptide binding]; other site
568819005949	structural Zn2+ binding site [ion binding]; other site
568819005950	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
568819005951	ABC-ATPase subunit  interface; other site
568819005952	dimer interface [polypeptide binding]; other site
568819005953	putative PBP binding regions; other site
568819005954	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
568819005955	ABC-ATPase subunit  interface; other site
568819005956	dimer interface [polypeptide binding]; other site
568819005957	putative PBP binding regions; other site
568819005958	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
568819005959	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: FeuA; cd01138
568819005960	putative ligand binding residues [chemical binding]; other site
568819005961	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
568819005962	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
568819005963	Walker A/P-loop; other site
568819005964	ATP binding site [chemical binding]; other site
568819005965	Q-loop/lid; other site
568819005966	ABC transporter signature motif; other site
568819005967	Walker B; other site
568819005968	D-loop; other site
568819005969	H-loop/switch region; other site
568819005970	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
568819005971	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819005972	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568819005973	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568819005974	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
568819005975	ABC-2 type transporter; Region: ABC2_membrane; cl11417
568819005976	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
568819005977	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
568819005978	Walker A/P-loop; other site
568819005979	ATP binding site [chemical binding]; other site
568819005980	Q-loop/lid; other site
568819005981	ABC transporter signature motif; other site
568819005982	Walker B; other site
568819005983	D-loop; other site
568819005984	H-loop/switch region; other site
568819005985	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
568819005986	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424
568819005987	dimer interface [polypeptide binding]; other site
568819005988	ADP-ribose binding site [chemical binding]; other site
568819005989	active site
568819005990	nudix motif; other site
568819005991	metal binding site [ion binding]; metal-binding site
568819005992	5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059
568819005993	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
568819005994	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
568819005995	active site
568819005996	DNA polymerase IV; Validated; Region: PRK02406
568819005997	DNA binding site [nucleotide binding]
568819005998	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
568819005999	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819006000	NAD(P) binding site [chemical binding]; other site
568819006001	active site
568819006002	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
568819006003	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
568819006004	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
568819006005	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
568819006006	Protein of unknown function (DUF1694); Region: DUF1694; cl02318
568819006007	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
568819006008	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
568819006009	Dehydratase family; Region: ILVD_EDD; cl00340
568819006010	dihydroxy-acid dehydratase; Region: ilvD; TIGR00110
568819006011	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710
568819006012	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
568819006013	PYR/PP interface [polypeptide binding]; other site
568819006014	dimer interface [polypeptide binding]; other site
568819006015	TPP binding site [chemical binding]; other site
568819006016	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
568819006017	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
568819006018	TPP-binding site [chemical binding]; other site
568819006019	dimer interface [polypeptide binding]; other site
568819006020	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
568819006021	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
568819006022	putative valine binding site [chemical binding]; other site
568819006023	dimer interface [polypeptide binding]; other site
568819006024	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
568819006025	ketol-acid reductoisomerase; Provisional; Region: PRK05479
568819006026	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819006027	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
568819006028	2-isopropylmalate synthase; Validated; Region: PRK00915
568819006029	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
568819006030	active site
568819006031	catalytic residues [active]
568819006032	metal binding site [ion binding]; metal-binding site
568819006033	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
568819006034	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
568819006035	isocitrate dehydrogenase; Validated; Region: PRK06451
568819006036	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
568819006037	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
568819006038	substrate binding site [chemical binding]; other site
568819006039	ligand binding site [chemical binding]; other site
568819006040	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577
568819006041	substrate binding site [chemical binding]; other site
568819006042	threonine dehydratase; Validated; Region: PRK08639
568819006043	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
568819006044	tetramer interface [polypeptide binding]; other site
568819006045	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819006046	catalytic residue [active]
568819006047	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141
568819006048	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408
568819006049	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
568819006050	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
568819006051	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
568819006052	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734
568819006053	Transcriptional regulators [Transcription]; Region: PurR; COG1609
568819006054	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568819006055	DNA binding site [nucleotide binding]
568819006056	domain linker motif; other site
568819006057	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
568819006058	dimerization interface [polypeptide binding]; other site
568819006059	ligand binding site [chemical binding]; other site
568819006060	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
568819006061	intersubunit interface [polypeptide binding]; other site
568819006062	active site
568819006063	catalytic residue [active]
568819006064	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
568819006065	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819006066	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
568819006067	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006
568819006068	active pocket/dimerization site; other site
568819006069	active site
568819006070	phosphorylation site [posttranslational modification]
568819006071	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
568819006072	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
568819006073	putative active site [active]
568819006074	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
568819006075	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
568819006076	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
568819006077	dimer interface [polypeptide binding]; other site
568819006078	active site
568819006079	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
568819006080	dimer interface [polypeptide binding]; other site
568819006081	active site
568819006082	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
568819006083	PTS system sorbose-specific iic component; Region: EII-Sor; cl01506
568819006084	Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four...; Region: PTS_IIB_man; cd00001
568819006085	active site
568819006086	phosphorylation site [posttranslational modification]
568819006087	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
568819006088	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819006089	DNA-binding site [nucleotide binding]; DNA binding site
568819006090	UTRA domain; Region: UTRA; cl01230
568819006091	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
568819006092	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819006093	DNA-binding site [nucleotide binding]; DNA binding site
568819006094	UTRA domain; Region: UTRA; cl01230
568819006095	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
568819006096	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
568819006097	active site
568819006098	catalytic tetrad [active]
568819006099	acetolactate synthase; Reviewed; Region: PRK08617
568819006100	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
568819006101	PYR/PP interface [polypeptide binding]; other site
568819006102	dimer interface [polypeptide binding]; other site
568819006103	TPP binding site [chemical binding]; other site
568819006104	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
568819006105	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
568819006106	TPP-binding site [chemical binding]; other site
568819006107	dimer interface [polypeptide binding]; other site
568819006108	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
568819006109	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
568819006110	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
568819006111	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819006112	dimer interface [polypeptide binding]; other site
568819006113	conserved gate region; other site
568819006114	ABC-ATPase subunit interface; other site
568819006115	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
568819006116	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819006117	dimer interface [polypeptide binding]; other site
568819006118	conserved gate region; other site
568819006119	ABC-ATPase subunit interface; other site
568819006122	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
568819006123	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
568819006124	Histidine kinase; Region: His_kinase; pfam06580
568819006125	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819006126	ATP binding site [chemical binding]; other site
568819006127	Mg2+ binding site [ion binding]; other site
568819006128	G-X-G motif; other site
568819006129	Protein of unknown function, DUF624; Region: DUF624; cl02369
568819006130	Uncharacterized conserved protein [Function unknown]; Region: COG3538
568819006131	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
568819006132	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
568819006133	Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074
568819006134	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
568819006135	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
568819006136	Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074
568819006137	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
568819006138	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458
568819006139	DNA-binding site [nucleotide binding]; DNA binding site
568819006140	RNA-binding motif; other site
568819006141	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
568819006142	active site
568819006143	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
568819006144	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
568819006145	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
568819006146	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
568819006147	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
568819006148	active site
568819006149	HIGH motif; other site
568819006150	nucleotide binding site [chemical binding]; other site
568819006151	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
568819006152	active site
568819006153	KMSKS motif; other site
568819006154	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
568819006155	tRNA binding surface [nucleotide binding]; other site
568819006156	anticodon binding site; other site
568819006157	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
568819006158	DivIVA protein; Region: DivIVA; pfam05103
568819006159	DivIVA domain; Region: DivI1A_domain; TIGR03544
568819006160	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
568819006161	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819006162	3H domain; Region: 3H; pfam02829
568819006163	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
568819006164	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
568819006165	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
568819006166	catalytic residue [active]
568819006167	L-aspartate oxidase; Provisional; Region: PRK08071
568819006168	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819006169	domain; Region: Succ_DH_flav_C; pfam02910
568819006170	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072
568819006171	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572
568819006172	dimerization interface [polypeptide binding]; other site
568819006173	active site
568819006174	Quinolinate synthetase A protein; Region: NadA; cl00420
568819006175	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006176	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
568819006177	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006178	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006179	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006180	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006181	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
568819006182	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006183	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
568819006184	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006185	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
568819006186	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006187	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006188	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006189	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006190	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
568819006191	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
568819006192	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006193	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006194	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
568819006195	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006196	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006197	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006198	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006199	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
568819006200	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006201	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
568819006202	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006203	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006204	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006205	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006206	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
568819006207	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006208	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006209	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006210	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006211	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
568819006212	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819006213	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
568819006214	S-adenosylmethionine binding site [chemical binding]; other site
568819006215	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568819006216	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568819006217	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
568819006218	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
568819006219	RNA binding surface [nucleotide binding]; other site
568819006220	YGGT family; Region: YGGT; cl00508
568819006221	Protein of unknown function (DUF552); Region: DUF552; cl00775
568819006222	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
568819006223	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
568819006224	catalytic residue [active]
568819006225	cell division protein FtsZ; Validated; Region: PRK09330
568819006226	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201
568819006227	nucleotide binding site [chemical binding]; other site
568819006228	SulA interaction site; other site
568819006229	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
568819006230	Cell division protein FtsA; Region: FtsA; cl11496
568819006231	Cell division protein FtsA; Region: FtsA; cl11496
568819006232	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
568819006233	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
568819006234	Cell division protein FtsQ; Region: FtsQ; pfam03799
568819006235	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
568819006236	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785
568819006237	active site
568819006238	homodimer interface [polypeptide binding]; other site
568819006239	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
568819006240	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
568819006241	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
568819006242	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
568819006243	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852
568819006244	Mg++ binding site [ion binding]; other site
568819006245	putative catalytic motif [active]
568819006246	putative substrate binding site [chemical binding]; other site
568819006247	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
568819006248	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
568819006249	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
568819006250	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
568819006251	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
568819006252	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
568819006253	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
568819006254	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
568819006255	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
568819006256	Septum formation initiator; Region: DivIC; cl11433
568819006257	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
568819006258	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
568819006259	cell division protein MraZ; Reviewed; Region: PRK00326
568819006260	MraZ protein; Region: MraZ; pfam02381
568819006261	MraZ protein; Region: MraZ; pfam02381
568819006262	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568819006263	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819006264	putative substrate translocation pore; other site
568819006265	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
568819006266	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
568819006267	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
568819006268	Protein of unknown function (DUF3397); Region: DUF3397; pfam11877
568819006269	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
568819006270	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819006271	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
568819006272	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
568819006273	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
568819006274	hypothetical protein; Provisional; Region: PRK13670
568819006275	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
568819006276	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
568819006277	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
568819006278	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119
568819006279	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819006280	Walker A/P-loop; other site
568819006281	ATP binding site [chemical binding]; other site
568819006282	Q-loop/lid; other site
568819006283	ABC transporter signature motif; other site
568819006284	Walker B; other site
568819006285	D-loop; other site
568819006286	H-loop/switch region; other site
568819006287	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
568819006288	PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986
568819006289	protein binding site [polypeptide binding]; other site
568819006290	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
568819006291	Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057
568819006292	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
568819006293	active site
568819006294	(T/H)XGH motif; other site
568819006295	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
568819006296	S-adenosylmethionine binding site [chemical binding]; other site
568819006297	Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453
568819006298	Protein of unknown function (DUF964); Region: DUF964; cl01483
568819006299	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
568819006300	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
568819006301	UbiA prenyltransferase family; Region: UbiA; cl00337
568819006302	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
568819006303	cytochrome c oxidase assembly protein; Provisional; Region: PTZ00127
568819006304	Ion transport protein; Region: Ion_trans; pfam00520
568819006305	Ion channel; Region: Ion_trans_2; cl11596
568819006306	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
568819006307	MOSC domain; Region: MOSC; pfam03473
568819006308	3-alpha domain; Region: 3-alpha; pfam03475
568819006309	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
568819006310	Copper resistance protein CopC; Region: CopC; cl01012
568819006311	Copper resistance protein D; Region: CopD; cl00563
568819006312	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
568819006313	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
568819006314	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-...; Region: Ntn_PVA; cd00542
568819006315	active site
568819006316	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
568819006317	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
568819006318	ring oligomerisation interface [polypeptide binding]; other site
568819006319	ATP/Mg binding site [chemical binding]; other site
568819006320	stacking interactions; other site
568819006321	hinge regions; other site
568819006322	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320
568819006323	oligomerisation interface [polypeptide binding]; other site
568819006324	mobile loop; other site
568819006325	roof hairpin; other site
568819006326	CAAX amino terminal protease self- immunity; Region: Abi; cl00558
568819006327	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
568819006328	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
568819006329	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819006330	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
568819006331	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
568819006332	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819006333	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
568819006334	ABC transporter; Region: ABC_tran_2; pfam12848
568819006335	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
568819006336	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
568819006337	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
568819006338	UGMP family protein; Validated; Region: PRK09604
568819006339	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
568819006340	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
568819006341	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568819006342	Coenzyme A binding pocket [chemical binding]; other site
568819006343	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
568819006344	Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520
568819006345	CrcB-like protein; Region: CRCB; cl09114
568819006346	CrcB-like protein; Region: CRCB; cl09114
568819006347	Uncharacterized conserved protein [Function unknown]; Region: COG4832
568819006348	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368
568819006349	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368
568819006350	Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173
568819006351	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
568819006352	active site
568819006353	substrate binding site [chemical binding]; other site
568819006354	ATP binding site [chemical binding]; other site
568819006355	Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619
568819006356	Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619
568819006357	Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619
568819006358	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
568819006359	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568819006360	non-specific DNA binding site [nucleotide binding]; other site
568819006361	salt bridge; other site
568819006362	sequence-specific DNA binding site [nucleotide binding]; other site
568819006363	multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575
568819006364	MatE; Region: MatE; cl10513
568819006365	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568819006366	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568819006367	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
568819006368	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
568819006369	substrate binding pocket [chemical binding]; other site
568819006370	Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137
568819006371	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
568819006372	ANP binding site [chemical binding]; other site
568819006373	Substrate Binding Site II [chemical binding]; other site
568819006374	Substrate Binding Site I [chemical binding]; other site
568819006375	argininosuccinate lyase; Provisional; Region: PRK00855
568819006376	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
568819006377	active sites [active]
568819006378	tetramer interface [polypeptide binding]; other site
568819006379	BCCT family transporter; Region: BCCT; cl00569
568819006380	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214
568819006381	active site
568819006382	intersubunit interface [polypeptide binding]; other site
568819006383	Zn2+ binding site [ion binding]; other site
568819006384	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
568819006385	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
568819006386	putative substrate binding site [chemical binding]; other site
568819006387	putative ATP binding site [chemical binding]; other site
568819006388	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
568819006389	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
568819006390	P-loop; other site
568819006391	active site
568819006392	phosphorylation site [posttranslational modification]
568819006393	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819006394	active site
568819006395	phosphorylation site [posttranslational modification]
568819006396	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
568819006397	PRD domain; Region: PRD; pfam00874
568819006398	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
568819006399	P-loop; other site
568819006400	active site
568819006401	phosphorylation site [posttranslational modification]
568819006402	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819006403	active site
568819006404	phosphorylation site [posttranslational modification]
568819006405	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
568819006406	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819006407	DNA-binding site [nucleotide binding]; DNA binding site
568819006408	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
568819006409	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819006410	homodimer interface [polypeptide binding]; other site
568819006411	catalytic residue [active]
568819006412	pyridoxal biosynthesis lyase PdxS; Provisional; Region: PRK04180
568819006413	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
568819006414	active site
568819006415	multimer interface [polypeptide binding]; other site
568819006416	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
568819006417	conserved cys residue [active]
568819006418	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
568819006419	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
568819006420	FeoA domain; Region: FeoA; cl00838
568819006421	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
568819006422	Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions.  FeoB has been identified as part of this...; Region: FeoB; cd01879
568819006423	G1 box; other site
568819006424	GTP/Mg2+ binding site [chemical binding]; other site
568819006425	Switch I region; other site
568819006426	G2 box; other site
568819006427	G3 box; other site
568819006428	Switch II region; other site
568819006429	G4 box; other site
568819006430	G5 box; other site
568819006431	Nucleoside recognition; Region: Gate; cl00486
568819006432	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
568819006433	Nucleoside recognition; Region: Gate; cl00486
568819006434	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
568819006435	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
568819006436	putative active site [active]
568819006437	putative metal binding site [ion binding]; other site
568819006438	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
568819006439	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819006440	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
568819006441	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
568819006442	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
568819006443	active site
568819006444	dimer interface [polypeptide binding]; other site
568819006445	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
568819006446	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
568819006447	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
568819006448	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH...; Region: NfsA_FRP; cd02146
568819006449	dimer interface [polypeptide binding]; other site
568819006450	FMN binding site [chemical binding]; other site
568819006451	NADPH bind site [chemical binding]; other site
568819006452	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
568819006453	Chlorite dismutase; Region: Chlor_dismutase; cl01280
568819006454	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
568819006455	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
568819006456	Walker A/P-loop; other site
568819006457	ATP binding site [chemical binding]; other site
568819006458	Q-loop/lid; other site
568819006459	ABC transporter signature motif; other site
568819006460	Walker B; other site
568819006461	D-loop; other site
568819006462	H-loop/switch region; other site
568819006463	FtsX-like permease family; Region: FtsX; pfam02687
568819006464	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568819006465	Coenzyme A binding pocket [chemical binding]; other site
568819006466	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
568819006467	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802
568819006468	active site
568819006469	substrate binding site [chemical binding]; other site
568819006470	metal binding site [ion binding]; metal-binding site
568819006471	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
568819006472	YbbR-like protein; Region: YbbR; pfam07949
568819006473	YbbR-like protein; Region: YbbR; pfam07949
568819006474	YbbR-like protein; Region: YbbR; pfam07949
568819006475	Uncharacterized conserved protein [Function unknown]; Region: COG1624
568819006476	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
568819006477	maltose phosphorylase; Provisional; Region: PRK13807
568819006478	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
568819006479	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
568819006480	Predicted integral membrane protein [Function unknown]; Region: COG5521
568819006481	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819006482	dimer interface [polypeptide binding]; other site
568819006483	conserved gate region; other site
568819006484	putative PBP binding loops; other site
568819006485	ABC-ATPase subunit interface; other site
568819006486	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819006487	dimer interface [polypeptide binding]; other site
568819006488	conserved gate region; other site
568819006489	putative PBP binding loops; other site
568819006490	ABC-ATPase subunit interface; other site
568819006491	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
568819006492	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
568819006493	CD and pullulan-degrading enzymes N-terminus domain.  Members of this subgroup include: Cyclomaltodextrinase (CDase), maltogenic amylase, and neopullulanase all of which are capable of hydrolyzing all or two of the following three types of substrates:...; Region: CD_pullulan_degrading_enzymes_N_term; cd02857
568819006494	homodimer; other site
568819006495	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
568819006496	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
568819006497	CAAX amino terminal protease family; Region: Abi; cl00558
568819006498	Transcriptional regulators [Transcription]; Region: PurR; COG1609
568819006499	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568819006500	DNA binding site [nucleotide binding]
568819006501	domain linker motif; other site
568819006502	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
568819006503	ligand binding site [chemical binding]; other site
568819006504	dimerization interface [polypeptide binding]; other site
568819006505	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
568819006506	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568819006507	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
568819006508	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568819006509	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
568819006510	ligand binding site [chemical binding]; other site
568819006511	flexible hinge region; other site
568819006512	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819006513	hypothetical protein; Provisional; Region: PRK08185
568819006514	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947
568819006515	intersubunit interface [polypeptide binding]; other site
568819006516	active site
568819006517	zinc binding site [ion binding]; other site
568819006518	Na+ binding site [ion binding]; other site
568819006519	hypothetical protein; Provisional; Region: PRK08185
568819006520	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947
568819006521	intersubunit interface [polypeptide binding]; other site
568819006522	active site
568819006523	zinc binding site [ion binding]; other site
568819006524	Na+ binding site [ion binding]; other site
568819006525	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
568819006526	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569
568819006527	P-loop; other site
568819006528	active site
568819006529	phosphorylation site [posttranslational modification]
568819006530	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819006531	active site
568819006532	phosphorylation site [posttranslational modification]
568819006533	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
568819006534	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819006535	PRD domain; Region: PRD; pfam00874
568819006536	PRD domain; Region: PRD; pfam00874
568819006537	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
568819006538	P-loop; other site
568819006539	active site
568819006540	phosphorylation site [posttranslational modification]
568819006541	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
568819006542	This subfamily is involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity.  In eubacteria and archaea, the typical organization consists of one ABC and one or two IMs.  Eukaryote systems of the ABCA subfamily...; Region: ABC_putative_ATPase; cd03269
568819006543	Walker A/P-loop; other site
568819006544	ATP binding site [chemical binding]; other site
568819006545	Q-loop/lid; other site
568819006546	ABC transporter signature motif; other site
568819006547	Walker B; other site
568819006548	D-loop; other site
568819006549	H-loop/switch region; other site
568819006550	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
568819006551	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
568819006552	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568819006553	Coenzyme A binding pocket [chemical binding]; other site
568819006554	Transcriptional regulators [Transcription]; Region: GntR; COG1802
568819006555	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
568819006556	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
568819006557	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
568819006558	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819006559	DNA-binding site [nucleotide binding]; DNA binding site
568819006560	UTRA domain; Region: UTRA; cl01230
568819006561	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
568819006562	Transcriptional regulator [Transcription]; Region: LysR; COG0583
568819006563	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819006564	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
568819006565	putative dimerization interface [polypeptide binding]; other site
568819006566	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
568819006567	Protein of unknown function (DUF1361); Region: DUF1361; cl01784
568819006568	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
568819006569	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
568819006570	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
568819006571	catalytic residues [active]
568819006572	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
568819006573	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
568819006574	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
568819006575	dimer interface [polypeptide binding]; other site
568819006576	putative radical transfer pathway; other site
568819006577	diiron center [ion binding]; other site
568819006578	tyrosyl radical; other site
568819006579	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209
568819006580	Class I ribonucleotide reductase; Region: RNR_I; cd01679
568819006581	active site
568819006582	dimer interface [polypeptide binding]; other site
568819006583	catalytic residues [active]
568819006584	effector binding site; other site
568819006585	R2 peptide binding site; other site
568819006586	Protein of unknown function (DUF1093); Region: DUF1093; cl02185
568819006587	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
568819006588	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
568819006589	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
568819006590	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819006591	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
568819006592	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
568819006593	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060
568819006594	DNA interaction; other site
568819006595	Metal-binding active site; metal-binding site
568819006596	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
568819006597	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
568819006598	conserved cys residue [active]
568819006599	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
568819006600	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
568819006601	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819006602	Cupin domain; Region: Cupin_2; cl09118
568819006603	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
568819006604	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568819006605	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568819006606	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
568819006607	ligand binding site [chemical binding]; other site
568819006608	flexible hinge region; other site
568819006609	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
568819006610	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
568819006611	dimer interface [polypeptide binding]; other site
568819006612	active site
568819006613	metal binding site [ion binding]; metal-binding site
568819006614	glutathione binding site [chemical binding]; other site
568819006615	putative enoyl-(acyl-carrier-protein) reductase II; Region: enACPred_II; TIGR03151
568819006616	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730
568819006617	FMN binding site [chemical binding]; other site
568819006618	substrate binding site [chemical binding]; other site
568819006619	putative catalytic residue [active]
568819006620	Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890
568819006621	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
568819006622	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
568819006623	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
568819006624	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
568819006625	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
568819006626	Walker A motif; other site
568819006627	ATP binding site [chemical binding]; other site
568819006628	Walker B motif; other site
568819006629	arginine finger; other site
568819006630	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
568819006631	Protein of unknown function (DUF1393); Region: DUF1393; cl01942
568819006632	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
568819006633	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
568819006634	metal binding site [ion binding]; metal-binding site
568819006635	active site
568819006636	I-site; other site
568819006637	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
568819006638	classical (c) SDRs; Region: SDR_c; cd05233
568819006639	NAD(P) binding site [chemical binding]; other site
568819006640	active site
568819006641	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568819006642	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568819006643	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
568819006644	Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619
568819006645	Collagen binding domain; Region: Collagen_bind; pfam05737
568819006646	Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619
568819006647	Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619
568819006648	Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619
568819006649	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
568819006650	Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619
568819006651	Collagen binding domain; Region: Collagen_bind; pfam05737
568819006652	Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619
568819006653	Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619
568819006654	Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619
568819006655	Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619
568819006656	Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619
568819006657	Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619
568819006658	MucBP domain; Region: MucBP; pfam06458
568819006659	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
568819006660	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
568819006661	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
568819006662	active site
568819006663	catalytic site [active]
568819006664	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
568819006665	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
568819006666	Walker A/P-loop; other site
568819006667	ATP binding site [chemical binding]; other site
568819006668	Q-loop/lid; other site
568819006669	ABC transporter signature motif; other site
568819006670	Walker B; other site
568819006671	D-loop; other site
568819006672	H-loop/switch region; other site
568819006673	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
568819006674	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
568819006675	ABC-ATPase subunit  interface; other site
568819006676	dimer interface [polypeptide binding]; other site
568819006677	putative PBP binding regions; other site
568819006678	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262
568819006679	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
568819006680	intersubunit interface [polypeptide binding]; other site
568819006681	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
568819006682	heme-binding site [chemical binding]; other site
568819006683	Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386
568819006684	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
568819006685	heme-binding site [chemical binding]; other site
568819006686	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
568819006687	heme-binding site [chemical binding]; other site
568819006688	sortase B cell surface sorting signal; Region: srtB_target; TIGR03063
568819006689	heme uptake protein IsdC; Region: IsdC; TIGR03656
568819006690	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
568819006691	heme-binding site [chemical binding]; other site
568819006692	sortase B cell surface sorting signal; Region: srtB_target; TIGR03063
568819006693	Protein of unknown function (DUF3116); Region: DUF3116; pfam11313
568819006694	oligoendopeptidase F; Region: pepF; TIGR00181
568819006695	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
568819006696	active site
568819006697	Zn binding site [ion binding]; other site
568819006698	Competence protein CoiA-like family; Region: CoiA; cl11541
568819006699	Negative regulator of genetic competence (MecA); Region: MecA; cl02022
568819006700	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting...; Region: ArsC_Spx; cd03032
568819006701	putative catalytic residues [active]
568819006702	thiol/disulfide switch; other site
568819006703	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
568819006704	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
568819006705	Walker A/P-loop; other site
568819006706	ATP binding site [chemical binding]; other site
568819006707	Q-loop/lid; other site
568819006708	ABC transporter signature motif; other site
568819006709	Walker B; other site
568819006710	D-loop; other site
568819006711	H-loop/switch region; other site
568819006712	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
568819006713	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
568819006714	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
568819006715	Walker A/P-loop; other site
568819006716	ATP binding site [chemical binding]; other site
568819006717	Q-loop/lid; other site
568819006718	ABC transporter signature motif; other site
568819006719	Walker B; other site
568819006720	D-loop; other site
568819006721	H-loop/switch region; other site
568819006722	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
568819006723	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819006724	dimer interface [polypeptide binding]; other site
568819006725	conserved gate region; other site
568819006726	putative PBP binding loops; other site
568819006727	ABC-ATPase subunit interface; other site
568819006728	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
568819006729	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819006730	dimer interface [polypeptide binding]; other site
568819006731	conserved gate region; other site
568819006732	putative PBP binding loops; other site
568819006733	ABC-ATPase subunit interface; other site
568819006734	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
568819006735	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
568819006736	peptide binding site [polypeptide binding]; other site
568819006737	tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233
568819006738	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
568819006739	active site
568819006740	HIGH motif; other site
568819006741	dimer interface [polypeptide binding]; other site
568819006742	KMSKS motif; other site
568819006743	OsmC-like protein; Region: OsmC; cl00767
568819006744	Transcriptional regulators [Transcription]; Region: MarR; COG1846
568819006745	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819006746	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
568819006747	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
568819006748	dimer interface [polypeptide binding]; other site
568819006749	active site
568819006750	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
568819006751	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
568819006752	dimer interface [polypeptide binding]; other site
568819006753	active site
568819006754	CoA binding pocket [chemical binding]; other site
568819006755	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743
568819006756	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
568819006757	Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300
568819006758	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
568819006759	catalytic core [active]
568819006760	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
568819006761	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
568819006762	Clp amino terminal domain; Region: Clp_N; pfam02861
568819006763	Clp amino terminal domain; Region: Clp_N; pfam02861
568819006764	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
568819006765	Walker A motif; other site
568819006766	ATP binding site [chemical binding]; other site
568819006767	Walker B motif; other site
568819006768	arginine finger; other site
568819006769	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
568819006770	Walker A motif; other site
568819006771	ATP binding site [chemical binding]; other site
568819006772	Walker B motif; other site
568819006773	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
568819006774	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
568819006775	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
568819006776	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
568819006777	active site
568819006778	motif I; other site
568819006779	motif II; other site
568819006780	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
568819006781	Predicted acetyltransferase [General function prediction only]; Region: COG3393
568819006782	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
568819006783	ferrochelatase; Provisional; Region: PRK12435
568819006784	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
568819006785	C-terminal domain interface [polypeptide binding]; other site
568819006786	active site
568819006787	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
568819006788	active site
568819006789	N-terminal domain interface [polypeptide binding]; other site
568819006790	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
568819006791	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717
568819006792	substrate binding site [chemical binding]; other site
568819006793	active site
568819006794	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
568819006795	Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542
568819006796	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
568819006797	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
568819006798	Walker A/P-loop; other site
568819006799	ATP binding site [chemical binding]; other site
568819006800	Q-loop/lid; other site
568819006801	ABC transporter signature motif; other site
568819006802	Walker B; other site
568819006803	D-loop; other site
568819006804	H-loop/switch region; other site
568819006805	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life...; Region: HINT_subgroup; cd01277
568819006806	HIT family signature motif; other site
568819006807	catalytic residue [active]
568819006808	YtxH-like protein; Region: YtxH; cl02079
568819006809	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
568819006810	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
568819006811	PPIC-type PPIASE domain; Region: Rotamase; cl08278
568819006812	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
568819006813	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492
568819006814	generic binding surface II; other site
568819006815	generic binding surface I; other site
568819006816	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
568819006817	Uncharacterized conserved protein [Function unknown]; Region: COG4717
568819006818	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
568819006819	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
568819006820	active site
568819006821	metal binding site [ion binding]; metal-binding site
568819006822	DNA binding site [nucleotide binding]
568819006823	Protein of unknown function (DUF964); Region: DUF964; cl01483
568819006824	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
568819006825	fumarate hydratase; Reviewed; Region: fumC; PRK00485
568819006826	Class II fumarases; Region: Fumarase_classII; cd01362
568819006827	active site
568819006828	tetramer interface [polypeptide binding]; other site
568819006829	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
568819006830	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
568819006831	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819006832	Walker A/P-loop; other site
568819006833	ATP binding site [chemical binding]; other site
568819006834	Q-loop/lid; other site
568819006835	ABC transporter signature motif; other site
568819006836	Walker B; other site
568819006837	D-loop; other site
568819006838	H-loop/switch region; other site
568819006839	Transglycosylase; Region: Transgly; cl07896
568819006840	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
568819006841	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
568819006842	Low molecular weight phosphatase family; Region: LMWPc; cl00105
568819006843	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
568819006844	Cation efflux family; Region: Cation_efflux; cl00316
568819006845	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
568819006846	Domain of unknown function DUF21; Region: DUF21; pfam01595
568819006847	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
568819006848	Transporter associated domain; Region: CorC_HlyC; cl08393
568819006849	Transcriptional regulator [Transcription]; Region: LysR; COG0583
568819006850	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819006851	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
568819006852	putative dimerization interface [polypeptide binding]; other site
568819006853	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
568819006854	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
568819006855	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as...; Region: OYE_like_FMN_family; cd02803
568819006856	active site
568819006857	FMN binding site [chemical binding]; other site
568819006858	substrate binding site [chemical binding]; other site
568819006859	putative catalytic residue [active]
568819006860	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819006861	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
568819006862	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
568819006863	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
568819006864	shikimate binding site; other site
568819006865	NAD(P) binding site [chemical binding]; other site
568819006866	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819006867	putative substrate translocation pore; other site
568819006868	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568819006869	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819006870	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568819006871	putative substrate translocation pore; other site
568819006872	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
568819006873	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
568819006874	Walker A/P-loop; other site
568819006875	ATP binding site [chemical binding]; other site
568819006876	Q-loop/lid; other site
568819006877	ABC transporter signature motif; other site
568819006878	Walker B; other site
568819006879	D-loop; other site
568819006880	H-loop/switch region; other site
568819006881	Predicted transcriptional regulators [Transcription]; Region: COG1725
568819006882	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819006883	DNA-binding site [nucleotide binding]; DNA binding site
568819006884	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
568819006885	DNA binding site [nucleotide binding]
568819006886	active site
568819006887	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
568819006888	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
568819006889	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568819006890	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568819006891	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
568819006892	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
568819006893	active site
568819006894	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
568819006895	putative dimer interface [polypeptide binding]; other site
568819006896	ligand binding site [chemical binding]; other site
568819006897	Zn binding site [ion binding]; other site
568819006898	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
568819006899	Active site [active]
568819006900	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
568819006901	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
568819006902	active site
568819006903	catalytic tetrad [active]
568819006904	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
568819006905	Phosphate transporter family; Region: PHO4; cl00396
568819006906	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
568819006907	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
568819006908	substrate binding pocket [chemical binding]; other site
568819006909	membrane-bound complex binding site; other site
568819006910	hinge residues; other site
568819006911	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
568819006912	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819006913	dimer interface [polypeptide binding]; other site
568819006914	conserved gate region; other site
568819006915	putative PBP binding loops; other site
568819006916	ABC-ATPase subunit interface; other site
568819006917	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
568819006918	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262
568819006919	Walker A/P-loop; other site
568819006920	ATP binding site [chemical binding]; other site
568819006921	Q-loop/lid; other site
568819006922	ABC transporter signature motif; other site
568819006923	Walker B; other site
568819006924	D-loop; other site
568819006925	H-loop/switch region; other site
568819006926	hypothetical protein; Validated; Region: PRK07682
568819006927	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
568819006928	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819006929	homodimer interface [polypeptide binding]; other site
568819006930	catalytic residue [active]
568819006931	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
568819006932	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
568819006933	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
568819006934	motif II; other site
568819006935	Sulfate transporter family; Region: Sulfate_transp; cl00967
568819006936	Permease family; Region: Xan_ur_permease; pfam00860
568819006937	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
568819006938	proposed catalytic triad [active]
568819006939	conserved cys residue [active]
568819006940	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
568819006941	methionine cluster; other site
568819006942	active site
568819006943	phosphorylation site [posttranslational modification]
568819006944	metal binding site [ion binding]; metal-binding site
568819006945	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
568819006946	Domain of unknown function DUF59; Region: DUF59; cl00941
568819006947	esterase; Provisional; Region: PRK10566
568819006948	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
568819006949	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
568819006950	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
568819006951	motif II; other site
568819006952	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
568819006953	Uncharacterized conserved protein [Function unknown]; Region: COG1284
568819006954	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
568819006955	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498
568819006956	Protein of unknown function (DUF1516); Region: DUF1516; cl11654
568819006957	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
568819006958	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
568819006959	helicase-exonuclease AddAB, AddA subunit; Region: addA_Gpos; TIGR02785
568819006960	UvrD/REP helicase; Region: UvrD-helicase; cl14126
568819006961	UvrD/REP helicase; Region: UvrD-helicase; cl14126
568819006962	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
568819006963	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
568819006964	UvrD/REP helicase; Region: UvrD-helicase; cl14126
568819006965	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
568819006966	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
568819006967	IDEAL domain; Region: IDEAL; cl07452
568819006968	ComK protein; Region: ComK; cl11560
568819006969	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568819006970	non-specific DNA binding site [nucleotide binding]; other site
568819006971	salt bridge; other site
568819006972	sequence-specific DNA binding site [nucleotide binding]; other site
568819006973	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
568819006974	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819006975	active site
568819006976	phosphorylation site [posttranslational modification]
568819006977	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569
568819006978	P-loop; other site
568819006979	active site
568819006980	phosphorylation site [posttranslational modification]
568819006981	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
568819006982	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
568819006983	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
568819006984	putative substrate binding site [chemical binding]; other site
568819006985	putative ATP binding site [chemical binding]; other site
568819006986	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
568819006987	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819006988	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
568819006989	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH...; Region: Peptidase_C1B; cd00585
568819006990	trimer interface [polypeptide binding]; other site
568819006991	active site
568819006992	G bulge; other site
568819006993	Protein of unknown function (DUF523); Region: DUF523; cl00733
568819006994	Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983
568819006995	putative kinase; Provisional; Region: PRK09954
568819006996	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819006997	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
568819006998	substrate binding site [chemical binding]; other site
568819006999	ATP binding site [chemical binding]; other site
568819007000	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
568819007001	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
568819007002	RNA binding surface [nucleotide binding]; other site
568819007003	PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553
568819007004	active site
568819007005	uracil binding [chemical binding]; other site
568819007006	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
568819007007	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
568819007008	active site
568819007009	non-prolyl cis peptide bond; other site
568819007010	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976
568819007011	catalytic residues [active]
568819007012	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
568819007013	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
568819007014	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
568819007015	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262
568819007016	Walker A/P-loop; other site
568819007017	ATP binding site [chemical binding]; other site
568819007018	Q-loop/lid; other site
568819007019	ABC transporter signature motif; other site
568819007020	Walker B; other site
568819007021	D-loop; other site
568819007022	H-loop/switch region; other site
568819007023	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
568819007024	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819007025	dimer interface [polypeptide binding]; other site
568819007026	conserved gate region; other site
568819007027	putative PBP binding loops; other site
568819007028	ABC-ATPase subunit interface; other site
568819007029	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
568819007030	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819007031	dimer interface [polypeptide binding]; other site
568819007032	conserved gate region; other site
568819007033	putative PBP binding loops; other site
568819007034	ABC-ATPase subunit interface; other site
568819007035	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
568819007036	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
568819007037	substrate binding pocket [chemical binding]; other site
568819007038	membrane-bound complex binding site; other site
568819007039	hinge residues; other site
568819007040	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
568819007041	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
568819007042	Transcriptional regulator [Transcription]; Region: LysR; COG0583
568819007043	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819007044	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
568819007045	dimerization interface [polypeptide binding]; other site
568819007046	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
568819007047	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
568819007048	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
568819007049	active site
568819007050	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819007051	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568819007052	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819007053	Uncharacterized conserved protein [Function unknown]; Region: HdeD; cl01277
568819007054	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination...; Region: GlcN6P_deaminase; cd01399
568819007055	active site
568819007056	trimer interface [polypeptide binding]; other site
568819007057	allosteric site; other site
568819007058	active site lid [active]
568819007059	hexamer (dimer of trimers) interface [polypeptide binding]; other site
568819007060	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
568819007061	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
568819007062	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
568819007063	Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298
568819007064	NAD binding site [chemical binding]; other site
568819007065	sugar binding site [chemical binding]; other site
568819007066	divalent metal binding site [ion binding]; other site
568819007067	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
568819007068	dimer interface [polypeptide binding]; other site
568819007069	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
568819007070	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819007071	PRD domain; Region: PRD; pfam00874
568819007072	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819007073	active site
568819007074	phosphorylation site [posttranslational modification]
568819007075	YdjC-like protein; Region: YdjC; cl01344
568819007076	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
568819007077	methionine cluster; other site
568819007078	active site
568819007079	phosphorylation site [posttranslational modification]
568819007080	metal binding site [ion binding]; metal-binding site
568819007081	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564
568819007082	active site
568819007083	P-loop; other site
568819007084	phosphorylation site [posttranslational modification]
568819007085	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
568819007086	Predicted membrane protein [Function unknown]; Region: COG1511
568819007087	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
568819007088	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
568819007089	ABC-2 type transporter; Region: ABC2_membrane; cl11417
568819007090	Predicted transcriptional regulator [Transcription]; Region: COG1959
568819007091	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819007092	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
568819007093	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
568819007094	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
568819007095	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819007096	catalytic residue [active]
568819007097	M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280
568819007098	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819007099	M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270
568819007100	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
568819007101	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819007102	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
568819007103	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
568819007104	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
568819007105	active site
568819007106	dimer interface [polypeptide binding]; other site
568819007107	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
568819007108	dimer interface [polypeptide binding]; other site
568819007109	active site
568819007110	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883
568819007111	nudix motif; other site
568819007112	general stress protein 13; Validated; Region: PRK08059
568819007113	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692
568819007114	RNA binding site [nucleotide binding]; other site
568819007115	aspartate aminotransferase; Provisional; Region: PRK08361
568819007116	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
568819007117	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819007118	homodimer interface [polypeptide binding]; other site
568819007119	catalytic residue [active]
568819007120	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
568819007121	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
568819007122	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
568819007123	Walker A/P-loop; other site
568819007124	ATP binding site [chemical binding]; other site
568819007125	Q-loop/lid; other site
568819007126	ABC transporter signature motif; other site
568819007127	Walker B; other site
568819007128	D-loop; other site
568819007129	H-loop/switch region; other site
568819007130	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564
568819007131	active site
568819007132	P-loop; other site
568819007133	phosphorylation site [posttranslational modification]
568819007134	aspartate kinase; Reviewed; Region: PRK09034
568819007135	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
568819007136	putative catalytic residues [active]
568819007137	putative nucleotide binding site [chemical binding]; other site
568819007138	putative aspartate binding site [chemical binding]; other site
568819007139	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
568819007140	allosteric regulatory residue; other site
568819007141	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
568819007142	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
568819007143	putative active site [active]
568819007144	putative NTP binding site [chemical binding]; other site
568819007145	putative nucleic acid binding site [nucleotide binding]; other site
568819007146	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
568819007147	active site
568819007148	drug efflux system protein MdtG; Provisional; Region: PRK09874
568819007149	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819007150	putative substrate translocation pore; other site
568819007151	monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
568819007152	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
568819007153	Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676
568819007154	Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676
568819007155	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
568819007156	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691
568819007157	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
568819007158	Na+/H+ ion antiporter subunit; Region: MNHE; cl00807
568819007159	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
568819007160	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583
568819007161	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
568819007162	CoenzymeA binding site [chemical binding]; other site
568819007163	subunit interaction site [polypeptide binding]; other site
568819007164	PHB binding site; other site
568819007165	Divergent PAP2 family; Region: DUF212; cl00855
568819007166	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
568819007167	Cl- selectivity filter; other site
568819007168	Cl- binding residues [ion binding]; other site
568819007169	pore gating glutamate residue; other site
568819007170	dimer interface [polypeptide binding]; other site
568819007171	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568819007172	Domain of unknown function (DUF1963); Region: DUF1963; cl01600
568819007173	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
568819007174	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819007175	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
568819007176	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819007177	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819007178	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
568819007179	NAD(P) binding site [chemical binding]; other site
568819007180	putative active site [active]
568819007181	Protein of unknown function (DUF1450); Region: DUF1450; cl11488
568819007182	Protein of unknown function (DUF1462); Region: DUF1462; cl11552
568819007183	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309
568819007184	Leucine-rich repeats; other site
568819007185	Substrate binding site [chemical binding]; other site
568819007186	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819007187	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819007188	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819007189	MucBP domain; Region: MucBP; pfam06458
568819007190	MucBP domain; Region: MucBP; pfam06458
568819007191	MucBP domain; Region: MucBP; pfam06458
568819007192	MucBP domain; Region: MucBP; pfam06458
568819007193	NifU-like domain; Region: NifU; cl00484
568819007194	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
568819007195	tetramer interfaces [polypeptide binding]; other site
568819007196	binuclear metal-binding site [ion binding]; other site
568819007197	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
568819007198	Domain of unknown function DUF21; Region: DUF21; pfam01595
568819007199	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
568819007200	Transporter associated domain; Region: CorC_HlyC; cl08393
568819007201	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
568819007202	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
568819007203	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
568819007204	active site
568819007205	motif I; other site
568819007206	motif II; other site
568819007207	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
568819007208	Protein of unknown function (DUF1027); Region: DUF1027; cl09961
568819007209	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
568819007210	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
568819007211	active site
568819007212	metal binding site [ion binding]; metal-binding site
568819007213	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
568819007214	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
568819007215	Protein of unknown function (DUF1634); Region: DUF1634; cl01741
568819007216	Protein of unknown function DUF72; Region: DUF72; cl00777
568819007217	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
568819007218	FeS assembly protein SufB; Region: sufB; TIGR01980
568819007219	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
568819007220	trimerization site [polypeptide binding]; other site
568819007221	active site
568819007222	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
568819007223	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
568819007224	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
568819007225	catalytic residue [active]
568819007226	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
568819007227	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
568819007228	FeS assembly ATPase SufC; Region: sufC; TIGR01978
568819007229	ABC-type transport system involved in Fe-S cluster assembly, ATPase component.  Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems.  The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217
568819007230	Walker A/P-loop; other site
568819007231	ATP binding site [chemical binding]; other site
568819007232	Q-loop/lid; other site
568819007233	ABC transporter signature motif; other site
568819007234	Walker B; other site
568819007235	D-loop; other site
568819007236	H-loop/switch region; other site
568819007237	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
568819007238	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819007239	ABC-ATPase subunit interface; other site
568819007240	putative PBP binding loops; other site
568819007241	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
568819007242	MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport.  Other members of this system include the MetP permease and  the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258
568819007243	Walker A/P-loop; other site
568819007244	ATP binding site [chemical binding]; other site
568819007245	Q-loop/lid; other site
568819007246	ABC transporter signature motif; other site
568819007247	Walker B; other site
568819007248	D-loop; other site
568819007249	H-loop/switch region; other site
568819007250	NIL domain; Region: NIL; cl09633
568819007251	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
568819007252	dimer interface [polypeptide binding]; other site
568819007253	phosphorylation site [posttranslational modification]
568819007254	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819007255	ATP binding site [chemical binding]; other site
568819007256	Mg2+ binding site [ion binding]; other site
568819007257	G-X-G motif; other site
568819007258	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568819007259	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
568819007260	active site
568819007261	phosphorylation site [posttranslational modification]
568819007262	intermolecular recognition site; other site
568819007263	dimerization interface [polypeptide binding]; other site
568819007264	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
568819007265	DNA binding site [nucleotide binding]
568819007266	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
568819007267	Cation efflux family; Region: Cation_efflux; cl00316
568819007268	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
568819007269	catalytic residues [active]
568819007270	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848
568819007271	lipoyl attachment site [posttranslational modification]; other site
568819007272	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
568819007273	putative ArsC-like catalytic residues; other site
568819007274	putative TRX-like catalytic residues [active]
568819007275	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
568819007276	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
568819007277	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
568819007278	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
568819007279	Walker A/P-loop; other site
568819007280	ATP binding site [chemical binding]; other site
568819007281	Q-loop/lid; other site
568819007282	ABC transporter signature motif; other site
568819007283	Walker B; other site
568819007284	D-loop; other site
568819007285	H-loop/switch region; other site
568819007286	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
568819007287	ABC-ATPase subunit  interface; other site
568819007288	dimer interface [polypeptide binding]; other site
568819007289	putative PBP binding regions; other site
568819007290	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262
568819007291	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
568819007292	intersubunit interface [polypeptide binding]; other site
568819007293	Putative esterase; Region: Esterase; pfam00756
568819007294	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
568819007295	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
568819007296	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
568819007297	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819007298	catalytic residue [active]
568819007299	Protein of unknown function (DUF1648); Region: DUF1648; cl01712
568819007300	CAT RNA binding domain; Region: CAT_RBD; cl03904
568819007301	transcriptional antiterminator BglG; Provisional; Region: PRK09772
568819007302	PRD domain; Region: PRD; pfam00874
568819007303	PRD domain; Region: PRD; pfam00874
568819007304	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
568819007305	Protein of unknown function (DUF1706); Region: DUF1706; cl01748
568819007306	Protein of unknown function (DUF1093); Region: DUF1093; cl02185
568819007307	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368
568819007308	Predicted transcriptional regulator [Transcription]; Region: COG2378
568819007309	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819007310	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
568819007311	putative active site [active]
568819007312	leucine-rich repeat receptor-like protein kinase; Provisional; Region: PLN00113
568819007313	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
568819007314	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402
568819007315	active site
568819007316	catalytic site [active]
568819007317	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
568819007318	putative metal binding site [ion binding]; other site
568819007319	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
568819007320	putative metal binding site [ion binding]; other site
568819007321	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
568819007322	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
568819007323	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
568819007324	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402
568819007325	active site
568819007326	catalytic site [active]
568819007327	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
568819007328	putative metal binding site [ion binding]; other site
568819007329	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
568819007330	C-terminal domain; Region: RGG_Cterm; TIGR01716
568819007331	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
568819007332	SmpB-tmRNA interface; other site
568819007333	ribonuclease R; Region: RNase_R; TIGR02063
568819007334	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927
568819007335	RNB domain; Region: RNB; pfam00773
568819007336	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471
568819007337	RNA binding site [nucleotide binding]; other site
568819007338	Esterase/lipase [General function prediction only]; Region: COG1647
568819007339	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
568819007340	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
568819007341	Esterase/lipase [General function prediction only]; Region: COG1647
568819007342	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
568819007343	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
568819007344	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
568819007345	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
568819007346	enolase; Provisional; Region: eno; PRK00077
568819007347	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
568819007348	dimer interface [polypeptide binding]; other site
568819007349	metal binding site [ion binding]; metal-binding site
568819007350	substrate binding pocket [chemical binding]; other site
568819007351	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
568819007352	Sulfatase; Region: Sulfatase; cl10460
568819007353	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
568819007354	substrate binding site [chemical binding]; other site
568819007355	dimer interface [polypeptide binding]; other site
568819007356	catalytic triad [active]
568819007357	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
568819007358	substrate binding site [chemical binding]; other site
568819007359	hinge regions; other site
568819007360	ADP binding site [chemical binding]; other site
568819007361	catalytic site [active]
568819007362	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267
568819007363	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
568819007364	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
568819007365	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
568819007366	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
568819007367	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
568819007368	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
568819007369	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
568819007370	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
568819007371	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics...; Region: rDP_like; cd01301
568819007372	active site
568819007373	dimer interface [polypeptide binding]; other site
568819007374	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
568819007375	Protein export membrane protein; Region: SecD_SecF; cl14618
568819007376	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568819007377	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568819007378	Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738
568819007379	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397
568819007380	Chitin binding domain; Region: Chitin_bind_3; cl03871
568819007381	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
568819007382	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
568819007383	Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036
568819007384	chitin/cellulose binding site [chemical binding]; other site
568819007385	Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036
568819007386	chitin/cellulose binding site [chemical binding]; other site
568819007387	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
568819007388	oligomer interface [polypeptide binding]; other site
568819007389	active site residues [active]
568819007390	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
568819007391	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
568819007392	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309
568819007393	Substrate binding site [chemical binding]; other site
568819007394	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819007395	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
568819007396	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
568819007397	active site
568819007398	FMN binding site [chemical binding]; other site
568819007399	substrate binding site [chemical binding]; other site
568819007400	homotetramer interface [polypeptide binding]; other site
568819007401	catalytic residue [active]
568819007402	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
568819007403	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
568819007404	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
568819007405	Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933
568819007406	phosphate binding site [ion binding]; other site
568819007407	putative substrate binding pocket [chemical binding]; other site
568819007408	dimer interface [polypeptide binding]; other site
568819007409	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819007410	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
568819007411	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799
568819007412	active site
568819007413	substrate binding site [chemical binding]; other site
568819007414	metal binding site [ion binding]; metal-binding site
568819007415	Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017
568819007416	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
568819007417	active site
568819007418	catalytic residues [active]
568819007419	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
568819007420	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
568819007421	NAD binding site [chemical binding]; other site
568819007422	homodimer interface [polypeptide binding]; other site
568819007423	active site
568819007424	substrate binding site [chemical binding]; other site
568819007425	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
568819007426	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819007427	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819007428	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
568819007429	binding surface
568819007430	TPR motif; other site
568819007431	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
568819007432	binding surface
568819007433	TPR motif; other site
568819007434	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
568819007435	putative trimer interface [polypeptide binding]; other site
568819007436	putative CoA binding site [chemical binding]; other site
568819007437	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
568819007438	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
568819007439	motif II; other site
568819007440	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
568819007441	HPr kinase/phosphorylase; Provisional; Region: PRK05428
568819007442	DRTGG domain; Region: DRTGG; cl12147
568819007443	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918
568819007444	Hpr binding site; other site
568819007445	active site
568819007446	homohexamer subunit interaction site [polypeptide binding]; other site
568819007447	Membrane protein of unknown function; Region: DUF360; cl00850
568819007448	PspC domain; Region: PspC; cl00864
568819007449	PspC domain; Region: PspC; cl00864
568819007450	Uncharacterized conserved protein [Function unknown]; Region: COG3595
568819007451	Uncharacterized conserved protein [Function unknown]; Region: COG3595
568819007452	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
568819007453	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
568819007454	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
568819007455	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
568819007456	excinuclease ABC subunit B; Provisional; Region: PRK05298
568819007457	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
568819007458	ATP binding site [chemical binding]; other site
568819007459	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568819007460	nucleotide binding region [chemical binding]; other site
568819007461	ATP-binding site [chemical binding]; other site
568819007462	Ultra-violet resistance protein B; Region: UvrB; pfam12344
568819007463	UvrB/uvrC motif; Region: UVR; pfam02151
568819007464	Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559
568819007465	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
568819007466	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568819007467	dimerization interface [polypeptide binding]; other site
568819007468	putative DNA binding site [nucleotide binding]; other site
568819007469	putative Zn2+ binding site [ion binding]; other site
568819007470	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
568819007471	PhoU domain; Region: PhoU; pfam01895
568819007472	PhoU domain; Region: PhoU; pfam01895
568819007473	phosphate transporter ATP-binding protein; Provisional; Region: PRK14240
568819007474	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
568819007475	Walker A/P-loop; other site
568819007476	ATP binding site [chemical binding]; other site
568819007477	Q-loop/lid; other site
568819007478	ABC transporter signature motif; other site
568819007479	Walker B; other site
568819007480	D-loop; other site
568819007481	H-loop/switch region; other site
568819007482	phosphate transporter ATP-binding protein; Provisional; Region: PRK14237
568819007483	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
568819007484	Walker A/P-loop; other site
568819007485	ATP binding site [chemical binding]; other site
568819007486	Q-loop/lid; other site
568819007487	ABC transporter signature motif; other site
568819007488	Walker B; other site
568819007489	D-loop; other site
568819007490	H-loop/switch region; other site
568819007491	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
568819007492	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819007493	dimer interface [polypeptide binding]; other site
568819007494	conserved gate region; other site
568819007495	putative PBP binding loops; other site
568819007496	ABC-ATPase subunit interface; other site
568819007497	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
568819007498	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819007499	dimer interface [polypeptide binding]; other site
568819007500	conserved gate region; other site
568819007501	putative PBP binding loops; other site
568819007502	ABC-ATPase subunit interface; other site
568819007503	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
568819007504	sensory histidine kinase DcuS; Provisional; Region: PRK11086
568819007505	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
568819007506	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
568819007507	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
568819007508	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
568819007509	dimer interface [polypeptide binding]; other site
568819007510	phosphorylation site [posttranslational modification]
568819007511	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819007512	ATP binding site [chemical binding]; other site
568819007513	Mg2+ binding site [ion binding]; other site
568819007514	G-X-G motif; other site
568819007515	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568819007516	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
568819007517	active site
568819007518	phosphorylation site [posttranslational modification]
568819007519	intermolecular recognition site; other site
568819007520	dimerization interface [polypeptide binding]; other site
568819007521	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
568819007522	DNA binding site [nucleotide binding]
568819007523	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
568819007524	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
568819007525	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
568819007526	putative active site [active]
568819007527	catalytic site [active]
568819007528	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
568819007529	putative active site [active]
568819007530	catalytic site [active]
568819007531	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
568819007532	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
568819007533	Peptidase family M23; Region: Peptidase_M23; pfam01551
568819007534	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
568819007535	NlpC/P60 family; Region: NLPC_P60; cl11438
568819007536	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
568819007537	FtsX-like permease family; Region: FtsX; pfam02687
568819007538	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
568819007539	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819007540	Walker A/P-loop; other site
568819007541	ATP binding site [chemical binding]; other site
568819007542	Q-loop/lid; other site
568819007543	ABC transporter signature motif; other site
568819007544	Walker B; other site
568819007545	D-loop; other site
568819007546	H-loop/switch region; other site
568819007547	Uncharacterized conserved protein [Function unknown]; Region: COG1284
568819007548	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
568819007549	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
568819007550	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498
568819007551	peptide chain release factor 2; Validated; Region: prfB; PRK00578
568819007552	RF-1 domain; Region: RF-1; cl02875
568819007553	RF-1 domain; Region: RF-1; cl02875
568819007554	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
568819007555	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819007556	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
568819007557	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819007558	SEC-C motif; Region: SEC-C; cl12132
568819007559	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552
568819007560	30S subunit binding site; other site
568819007561	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
568819007562	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
568819007563	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
568819007564	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
568819007565	ATP binding site [chemical binding]; other site
568819007566	putative Mg++ binding site [ion binding]; other site
568819007567	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819007568	Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577
568819007569	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
568819007570	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
568819007571	active site
568819007572	phosphorylation site [posttranslational modification]
568819007573	intermolecular recognition site; other site
568819007574	dimerization interface [polypeptide binding]; other site
568819007575	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
568819007576	DNA binding residues [nucleotide binding]
568819007577	dimerization interface [polypeptide binding]; other site
568819007578	Uncharacterized conserved protein [Function unknown]; Region: COG1739
568819007579	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
568819007580	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
568819007581	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
568819007582	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
568819007583	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
568819007584	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
568819007585	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
568819007586	Mg++ binding site [ion binding]; other site
568819007587	putative catalytic motif [active]
568819007588	substrate binding site [chemical binding]; other site
568819007589	N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317
568819007590	o-succinylbenzoic acid (OSB) synthetase; Region: menC_lowGC/arch; TIGR01928
568819007591	active site
568819007592	octamer interface [polypeptide binding]; other site
568819007593	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
568819007594	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
568819007595	putative peptidoglycan binding site; other site
568819007596	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
568819007597	putative peptidoglycan binding site; other site
568819007598	3D domain; Region: 3D; cl01439
568819007599	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
568819007600	dimer interface [polypeptide binding]; other site
568819007601	ssDNA binding site [nucleotide binding]; other site
568819007602	tetramer (dimer of dimers) interface [polypeptide binding]; other site
568819007603	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
568819007604	rod shape-determining protein Mbl; Provisional; Region: PRK13928
568819007605	Cell division protein FtsA; Region: FtsA; cl11496
568819007606	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369
568819007607	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
568819007608	hinge; other site
568819007609	active site
568819007610	Protein of unknown function (DUF1146); Region: DUF1146; cl11486
568819007611	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
568819007612	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
568819007613	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
568819007614	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
568819007615	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
568819007616	alpha subunit interaction interface [polypeptide binding]; other site
568819007617	Walker A motif; other site
568819007618	ATP binding site [chemical binding]; other site
568819007619	Walker B motif; other site
568819007620	inhibitor binding site; inhibition site
568819007621	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
568819007622	ATP synthase; Region: ATP-synt; cl00365
568819007623	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
568819007624	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
568819007625	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
568819007626	beta subunit interaction interface [polypeptide binding]; other site
568819007627	Walker A motif; other site
568819007628	ATP binding site [chemical binding]; other site
568819007629	Walker B motif; other site
568819007630	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
568819007631	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
568819007632	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
568819007633	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
568819007634	ATP synthase subunit C; Region: ATP-synt_C; cl00466
568819007635	ATP synthase A chain; Region: ATP-synt_A; cl00413
568819007636	ATP synthase I chain; Region: ATP_synt_I; cl09170
568819007637	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
568819007638	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
568819007639	active site
568819007640	homodimer interface [polypeptide binding]; other site
568819007641	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
568819007642	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
568819007643	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378
568819007644	dimer interface [polypeptide binding]; other site
568819007645	glycine-pyridoxal phosphate binding site [chemical binding]; other site
568819007646	active site
568819007647	folate binding site [chemical binding]; other site
568819007648	Low molecular weight phosphatase family; Region: LMWPc; cd00115
568819007649	Active site [active]
568819007650	yrdC domain; Region: Sua5_yciO_yrdC; cl00305
568819007651	SUA5 domain; Region: SUA5; pfam03481
568819007652	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
568819007653	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
568819007654	S-adenosylmethionine binding site [chemical binding]; other site
568819007655	peptide chain release factor 1; Validated; Region: prfA; PRK00591
568819007656	RF-1 domain; Region: RF-1; cl02875
568819007657	RF-1 domain; Region: RF-1; cl02875
568819007658	Thymidine kinase; Region: TK; cl00631
568819007659	homoserine kinase; Provisional; Region: PRK01212
568819007660	GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256
568819007661	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
568819007662	threonine synthase; Reviewed; Region: PRK06721
568819007663	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563
568819007664	homodimer interface [polypeptide binding]; other site
568819007665	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819007666	catalytic residue [active]
568819007667	homoserine dehydrogenase; Provisional; Region: PRK06349
568819007668	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819007669	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
568819007670	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
568819007671	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
568819007672	GtrA-like protein; Region: GtrA; cl00971
568819007673	transcription termination factor Rho; Provisional; Region: rho; PRK09376
568819007674	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
568819007675	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459
568819007676	RNA binding site [nucleotide binding]; other site
568819007677	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128
568819007678	multimer interface [polypeptide binding]; other site
568819007679	Walker A motif; other site
568819007680	ATP binding site [chemical binding]; other site
568819007681	Walker B motif; other site
568819007682	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369
568819007683	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
568819007684	hinge; other site
568819007685	active site
568819007686	Predicted integral membrane protein [Function unknown]; Region: COG0392
568819007687	Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219
568819007688	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
568819007689	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
568819007690	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-...; Region: GT1_UGDG_like; cd03817
568819007691	putative ADP-binding pocket [chemical binding]; other site
568819007692	hypothetical protein; Provisional; Region: PRK08185
568819007693	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947
568819007694	intersubunit interface [polypeptide binding]; other site
568819007695	active site
568819007696	zinc binding site [ion binding]; other site
568819007697	Na+ binding site [ion binding]; other site
568819007698	putative lipid kinase; Reviewed; Region: PRK13055
568819007699	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
568819007700	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
568819007701	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
568819007702	substrate binding site [chemical binding]; other site
568819007703	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
568819007704	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
568819007705	CTP synthetase; Validated; Region: pyrG; PRK05380
568819007706	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113
568819007707	Catalytic site [active]
568819007708	Active site [active]
568819007709	UTP binding site [chemical binding]; other site
568819007710	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
568819007711	active site
568819007712	putative oxyanion hole; other site
568819007713	catalytic triad [active]
568819007714	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319
568819007715	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104
568819007716	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
568819007717	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
568819007718	active site
568819007719	HIGH motif; other site
568819007720	KMSK motif region; other site
568819007721	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
568819007722	tRNA binding surface [nucleotide binding]; other site
568819007723	anticodon binding site; other site
568819007724	Domain of unknown function (DUF1934); Region: DUF1934; cl01870
568819007725	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
568819007726	active site
568819007727	putative substrate binding region [chemical binding]; other site
568819007728	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
568819007729	active site 1 [active]
568819007730	dimer interface [polypeptide binding]; other site
568819007731	hexamer interface [polypeptide binding]; other site
568819007732	active site 2 [active]
568819007733	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
568819007734	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
568819007735	Zn2+ binding site [ion binding]; other site
568819007736	Mg2+ binding site [ion binding]; other site
568819007737	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
568819007738	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
568819007739	Protein of unknown function (DUF1093); Region: DUF1093; cl02185
568819007740	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
568819007741	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
568819007742	peptide binding site [polypeptide binding]; other site
568819007743	Protein of unknown function (DUF1648); Region: DUF1648; cl01712
568819007744	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
568819007745	catalytic triad [active]
568819007746	metal binding site [ion binding]; metal-binding site
568819007747	conserved cis-peptide bond; other site
568819007748	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161
568819007749	folate binding site [chemical binding]; other site
568819007750	NADP+ binding site [chemical binding]; other site
568819007751	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
568819007752	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
568819007753	putative NAD(P) binding site [chemical binding]; other site
568819007754	dimer interface [polypeptide binding]; other site
568819007755	Cation efflux family; Region: Cation_efflux; cl00316
568819007756	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
568819007757	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
568819007758	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
568819007759	active site
568819007760	motif I; other site
568819007761	motif II; other site
568819007762	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
568819007763	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892
568819007764	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
568819007765	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
568819007766	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
568819007767	Walker A/P-loop; other site
568819007768	ATP binding site [chemical binding]; other site
568819007769	Q-loop/lid; other site
568819007770	ABC transporter signature motif; other site
568819007771	Walker B; other site
568819007772	D-loop; other site
568819007773	H-loop/switch region; other site
568819007774	FtsX-like permease family; Region: FtsX; pfam02687
568819007775	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
568819007776	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
568819007777	dimerization interface [polypeptide binding]; other site
568819007778	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
568819007779	dimer interface [polypeptide binding]; other site
568819007780	phosphorylation site [posttranslational modification]
568819007781	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819007782	ATP binding site [chemical binding]; other site
568819007783	Mg2+ binding site [ion binding]; other site
568819007784	G-X-G motif; other site
568819007785	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568819007786	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
568819007787	active site
568819007788	phosphorylation site [posttranslational modification]
568819007789	intermolecular recognition site; other site
568819007790	dimerization interface [polypeptide binding]; other site
568819007791	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
568819007792	DNA binding site [nucleotide binding]
568819007793	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
568819007794	Protein of unknown function (DUF1641); Region: DUF1641; cl01025
568819007795	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
568819007796	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
568819007797	catalytic loop [active]
568819007798	iron binding site [ion binding]; other site
568819007799	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
568819007800	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H)...; Region: MopB_Formate-Dh-H; cd02753
568819007801	[4Fe-4S] binding site [ion binding]; other site
568819007802	molybdopterin cofactor binding site; other site
568819007803	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
568819007804	molybdopterin cofactor binding site; other site
568819007805	Uncharacterized conserved protein [Function unknown]; Region: COG1912
568819007806	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
568819007807	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819007808	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568819007809	putative substrate translocation pore; other site
568819007810	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568819007811	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568819007812	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
568819007813	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743
568819007814	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
568819007815	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
568819007816	active site
568819007817	catalytic tetrad [active]
568819007818	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
568819007819	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
568819007820	DNA binding residues [nucleotide binding]
568819007821	putative dimer interface [polypeptide binding]; other site
568819007822	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
568819007823	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
568819007824	23S rRNA interface [nucleotide binding]; other site
568819007825	L3 interface [polypeptide binding]; other site
568819007826	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
568819007827	PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570
568819007828	dimerization interface 3.5A [polypeptide binding]; other site
568819007829	active site
568819007830	Cobalt transport protein; Region: CbiQ; cl00463
568819007831	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634
568819007832	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This...; Region: ABC_cobalt_CbiO_domain1; cd03225
568819007833	Walker A/P-loop; other site
568819007834	ATP binding site [chemical binding]; other site
568819007835	Q-loop/lid; other site
568819007836	ABC transporter signature motif; other site
568819007837	Walker B; other site
568819007838	D-loop; other site
568819007839	H-loop/switch region; other site
568819007840	Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370
568819007841	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635
568819007842	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This...; Region: ABC_cobalt_CbiO_domain1; cd03225
568819007843	Walker A/P-loop; other site
568819007844	ATP binding site [chemical binding]; other site
568819007845	Q-loop/lid; other site
568819007846	ABC transporter signature motif; other site
568819007847	Walker B; other site
568819007848	D-loop; other site
568819007849	H-loop/switch region; other site
568819007850	Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370
568819007851	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
568819007852	MgtC family; Region: MgtC; cl12207
568819007853	Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023
568819007854	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
568819007855	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
568819007856	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
568819007857	alphaNTD - beta interaction site [polypeptide binding]; other site
568819007858	alphaNTD homodimer interface [polypeptide binding]; other site
568819007859	alphaNTD - beta' interaction site [polypeptide binding]; other site
568819007860	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
568819007861	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
568819007862	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
568819007863	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
568819007864	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
568819007865	rRNA binding site [nucleotide binding]; other site
568819007866	predicted 30S ribosome binding site; other site
568819007867	adenylate kinase; Reviewed; Region: adk; PRK00279
568819007868	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
568819007869	AMP-binding site [chemical binding]; other site
568819007870	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
568819007871	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
568819007872	SecY translocase; Region: SecY; pfam00344
568819007873	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
568819007874	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658
568819007875	23S rRNA binding site [nucleotide binding]; other site
568819007876	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
568819007877	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
568819007878	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
568819007879	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
568819007880	5S rRNA interface [nucleotide binding]; other site
568819007881	L27 interface [polypeptide binding]; other site
568819007882	23S rRNA interface [nucleotide binding]; other site
568819007883	L5 interface [polypeptide binding]; other site
568819007884	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
568819007885	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
568819007886	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
568819007887	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
568819007888	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
568819007889	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
568819007890	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
568819007891	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
568819007892	KOW motif; Region: KOW; cl00354
568819007893	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
568819007894	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
568819007895	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427
568819007896	23S rRNA interface [nucleotide binding]; other site
568819007897	putative translocon interaction site; other site
568819007898	signal recognition particle (SRP54) interaction site; other site
568819007899	L23 interface [polypeptide binding]; other site
568819007900	trigger factor interaction site; other site
568819007901	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
568819007902	23S rRNA interface [nucleotide binding]; other site
568819007903	5S rRNA interface [nucleotide binding]; other site
568819007904	putative antibiotic binding site [chemical binding]; other site
568819007905	L25 interface [polypeptide binding]; other site
568819007906	L27 interface [polypeptide binding]; other site
568819007907	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
568819007908	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The...; Region: 30S_S3_KH; cd02412
568819007909	G-X-X-G motif; other site
568819007910	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
568819007911	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
568819007912	putative translocon binding site; other site
568819007913	protein-rRNA interface [nucleotide binding]; other site
568819007914	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
568819007915	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
568819007916	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
568819007917	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
568819007918	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
568819007919	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
568819007920	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
568819007921	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
568819007922	Cobalt transport protein; Region: CbiQ; cl00463
568819007923	UbiA prenyltransferase family; Region: UbiA; cl00337
568819007924	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; COG1575
568819007925	ApbE family; Region: ApbE; cl00643
568819007926	Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939
568819007927	FMN-binding domain; Region: FMN_bind; cl01081
568819007928	FMN-binding domain; Region: FMN_bind; cl01081
568819007929	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
568819007930	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819007931	DoxX; Region: DoxX; cl00976
568819007932	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
568819007933	trimer interface [polypeptide binding]; other site
568819007934	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973
568819007935	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
568819007936	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
568819007937	substrate binding pocket [chemical binding]; other site
568819007938	chain length determination region; other site
568819007939	substrate-Mg2+ binding site; other site
568819007940	catalytic residues [active]
568819007941	aspartate-rich region 1; other site
568819007942	active site lid residues [active]
568819007943	aspartate-rich region 2; other site
568819007944	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
568819007945	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
568819007946	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
568819007947	active site
568819007948	metal binding site [ion binding]; metal-binding site
568819007949	hypothetical protein; Provisional; Region: PRK02947
568819007950	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013
568819007951	putative active site [active]
568819007952	Protein of unknown function (DUF1341); Region: DUF1341; cl06211
568819007953	Creatinine amidohydrolase; Region: Creatininase; cl00618
568819007954	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: Php; COG1735
568819007955	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active...; Region: PTE; cd00530
568819007956	active site
568819007957	substrate binding pocket [chemical binding]; other site
568819007958	homodimer interaction site [polypeptide binding]; other site
568819007959	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
568819007960	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
568819007961	P-loop; other site
568819007962	active site
568819007963	phosphorylation site [posttranslational modification]
568819007964	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819007965	active site
568819007966	phosphorylation site [posttranslational modification]
568819007967	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
568819007968	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819007969	PRD domain; Region: PRD; pfam00874
568819007970	PRD domain; Region: PRD; pfam00874
568819007971	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
568819007972	P-loop; other site
568819007973	active site
568819007974	phosphorylation site [posttranslational modification]
568819007975	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819007976	active site
568819007977	phosphorylation site [posttranslational modification]
568819007978	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
568819007979	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819007980	Walker A/P-loop; other site
568819007981	ATP binding site [chemical binding]; other site
568819007982	Q-loop/lid; other site
568819007983	ABC transporter signature motif; other site
568819007984	Walker B; other site
568819007985	D-loop; other site
568819007986	H-loop/switch region; other site
568819007987	elongation factor Tu; Reviewed; Region: PRK00049
568819007988	EF-Tu subfamily.  This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts.  It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884
568819007989	G1 box; other site
568819007990	GEF interaction site [polypeptide binding]; other site
568819007991	GTP/Mg2+ binding site [chemical binding]; other site
568819007992	Switch I region; other site
568819007993	G2 box; other site
568819007994	G3 box; other site
568819007995	Switch II region; other site
568819007996	G4 box; other site
568819007997	G5 box; other site
568819007998	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
568819007999	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707
568819008000	Antibiotic Binding Site [chemical binding]; other site
568819008001	elongation factor G; Reviewed; Region: PRK00007
568819008002	Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase).  The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA.  This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886
568819008003	G1 box; other site
568819008004	putative GEF interaction site [polypeptide binding]; other site
568819008005	GTP/Mg2+ binding site [chemical binding]; other site
568819008006	Switch I region; other site
568819008007	G2 box; other site
568819008008	G3 box; other site
568819008009	Switch II region; other site
568819008010	G4 box; other site
568819008011	G5 box; other site
568819008012	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088
568819008013	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434
568819008014	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713
568819008015	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
568819008016	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
568819008017	S17 interaction site [polypeptide binding]; other site
568819008018	S8 interaction site; other site
568819008019	16S rRNA interaction site [nucleotide binding]; other site
568819008020	streptomycin interaction site [chemical binding]; other site
568819008021	23S rRNA interaction site [nucleotide binding]; other site
568819008022	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
568819008023	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
568819008024	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
568819008025	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568819008026	Coenzyme A binding pocket [chemical binding]; other site
568819008027	MucBP domain; Region: MucBP; pfam06458
568819008028	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
568819008029	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429
568819008030	substrate binding site [chemical binding]; other site
568819008031	hexamer interface [polypeptide binding]; other site
568819008032	metal binding site [ion binding]; metal-binding site
568819008033	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
568819008034	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
568819008035	TPP-binding site [chemical binding]; other site
568819008036	dimer interface [polypeptide binding]; other site
568819008037	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
568819008038	PYR/PP interface [polypeptide binding]; other site
568819008039	dimer interface [polypeptide binding]; other site
568819008040	TPP binding site [chemical binding]; other site
568819008041	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
568819008042	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429
568819008043	substrate binding site [chemical binding]; other site
568819008044	hexamer interface [polypeptide binding]; other site
568819008045	metal binding site [ion binding]; metal-binding site
568819008046	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
568819008047	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
568819008048	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258
568819008049	putative NAD(P) binding site [chemical binding]; other site
568819008050	catalytic Zn binding site [ion binding]; other site
568819008051	structural Zn binding site [ion binding]; other site
568819008052	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
568819008053	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
568819008054	putative NAD(P) binding site [chemical binding]; other site
568819008055	catalytic Zn binding site [ion binding]; other site
568819008056	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
568819008057	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
568819008058	P-loop; other site
568819008059	active site
568819008060	phosphorylation site [posttranslational modification]
568819008061	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819008062	active site
568819008063	phosphorylation site [posttranslational modification]
568819008064	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
568819008065	PRD domain; Region: PRD; pfam00874
568819008066	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
568819008067	P-loop; other site
568819008068	active site
568819008069	phosphorylation site [posttranslational modification]
568819008070	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819008071	active site
568819008072	phosphorylation site [posttranslational modification]
568819008073	Predicted membrane protein [Function unknown]; Region: COG4905
568819008074	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
568819008075	Protein of unknown function (DUF419); Region: DUF419; cl15265
568819008076	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
568819008077	active site
568819008078	metal binding site [ion binding]; metal-binding site
568819008079	Helix-turn-helix domain; Region: HTH_18; pfam12833
568819008080	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
568819008081	Ligand Binding Site [chemical binding]; other site
568819008082	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
568819008083	DNA polymerase IV; Reviewed; Region: PRK03103
568819008084	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
568819008085	active site
568819008086	DNA binding site [nucleotide binding]
568819008087	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
568819008088	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
568819008089	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
568819008090	active site
568819008091	phosphorylation site [posttranslational modification]
568819008092	intermolecular recognition site; other site
568819008093	dimerization interface [polypeptide binding]; other site
568819008094	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
568819008095	DNA binding site [nucleotide binding]
568819008096	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
568819008097	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
568819008098	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
568819008099	Ligand Binding Site [chemical binding]; other site
568819008100	GAF domain; Region: GAF; cl00853
568819008101	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
568819008102	dimer interface [polypeptide binding]; other site
568819008103	phosphorylation site [posttranslational modification]
568819008104	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819008105	ATP binding site [chemical binding]; other site
568819008106	Mg2+ binding site [ion binding]; other site
568819008107	G-X-G motif; other site
568819008108	K+-transporting ATPase, c chain; Region: KdpC; cl00944
568819008109	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
568819008110	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
568819008111	K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; cl00903
568819008112	Potassium-transporting ATPase A subunit; Region: KdpA; pfam03814
568819008113	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564
568819008114	active site
568819008115	P-loop; other site
568819008116	phosphorylation site [posttranslational modification]
568819008117	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
568819008118	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
568819008119	methionine cluster; other site
568819008120	active site
568819008121	phosphorylation site [posttranslational modification]
568819008122	metal binding site [ion binding]; metal-binding site
568819008123	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
568819008124	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
568819008125	magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524
568819008126	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
568819008127	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
568819008128	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
568819008129	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
568819008130	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568819008131	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568819008132	autolysin; Reviewed; Region: PRK06347
568819008133	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743
568819008134	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
568819008135	putative peptidoglycan binding site; other site
568819008136	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
568819008137	putative peptidoglycan binding site; other site
568819008138	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
568819008139	putative peptidoglycan binding site; other site
568819008140	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
568819008141	putative peptidoglycan binding site; other site
568819008142	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412
568819008143	thymidylate kinase; Validated; Region: tmk; PRK00698
568819008144	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672
568819008145	TMP-binding site; other site
568819008146	ATP-binding site [chemical binding]; other site
568819008147	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
568819008148	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
568819008149	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
568819008150	catalytic residue [active]
568819008151	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
568819008152	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
568819008153	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
568819008154	DAK2 domain; Region: Dak2; cl03685
568819008155	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cl00025
568819008156	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
568819008157	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013
568819008158	putative active site [active]
568819008159	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
568819008160	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
568819008161	active site
568819008162	motif I; other site
568819008163	motif II; other site
568819008164	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
568819008165	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
568819008166	nudix motif; other site
568819008167	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
568819008168	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
568819008169	active site
568819008170	catalytic tetrad [active]
568819008171	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
568819008172	recombination protein RecR; Reviewed; Region: recR; PRK00076
568819008173	RecR protein; Region: RecR; pfam02132
568819008174	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
568819008175	putative active site [active]
568819008176	putative metal-binding site [ion binding]; other site
568819008177	tetramer interface [polypeptide binding]; other site
568819008178	Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494
568819008179	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
568819008180	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
568819008181	Walker A motif; other site
568819008182	ATP binding site [chemical binding]; other site
568819008183	Walker B motif; other site
568819008184	arginine finger; other site
568819008185	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
568819008186	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
568819008187	Protein of unknown function (DUF3188); Region: DUF3188; pfam11384
568819008188	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
568819008190	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
568819008191	gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
568819008192	N- and C-terminal domain interface [polypeptide binding]; other site
568819008193	putative active site [active]
568819008194	catalytic site [active]
568819008195	metal binding site [ion binding]; metal-binding site
568819008196	carbohydrate binding site [chemical binding]; other site
568819008197	ATP binding site [chemical binding]; other site
568819008198	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
568819008199	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
568819008200	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
568819008201	The CYD subfamily implicated in cytochrome bd biogenesis.  The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd...; Region: ABCC_cytochrome_bd; cd03247
568819008202	Walker A/P-loop; other site
568819008203	ATP binding site [chemical binding]; other site
568819008204	Q-loop/lid; other site
568819008205	ABC transporter signature motif; other site
568819008206	Walker B; other site
568819008207	D-loop; other site
568819008208	H-loop/switch region; other site
568819008209	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
568819008210	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
568819008211	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819008212	Walker A/P-loop; other site
568819008213	ATP binding site [chemical binding]; other site
568819008214	Q-loop/lid; other site
568819008215	ABC transporter signature motif; other site
568819008216	Walker B; other site
568819008217	D-loop; other site
568819008218	H-loop/switch region; other site
568819008219	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
568819008220	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
568819008221	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
568819008222	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
568819008223	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
568819008224	nucleoside/Zn binding site; other site
568819008225	dimer interface [polypeptide binding]; other site
568819008226	catalytic motif [active]
568819008227	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
568819008228	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
568819008229	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination...; Region: GlcN6P_deaminase; cd01399
568819008230	active site
568819008231	trimer interface [polypeptide binding]; other site
568819008232	allosteric site; other site
568819008233	active site lid [active]
568819008234	hexamer (dimer of trimers) interface [polypeptide binding]; other site
568819008235	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
568819008236	DNA binding residues [nucleotide binding]
568819008237	drug binding residues [chemical binding]; other site
568819008238	dimer interface [polypeptide binding]; other site
568819008239	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
568819008240	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
568819008241	dimer interface [polypeptide binding]; other site
568819008242	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
568819008243	MatE; Region: MatE; cl10513
568819008244	MatE; Region: MatE; cl10513
568819008245	Transcriptional regulators [Transcription]; Region: MarR; COG1846
568819008246	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819008247	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
568819008248	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
568819008249	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
568819008250	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
568819008251	DNA binding residues [nucleotide binding]
568819008252	putative dimer interface [polypeptide binding]; other site
568819008253	Cupin domain; Region: Cupin_2; cl09118
568819008254	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
568819008255	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
568819008256	active site
568819008257	motif I; other site
568819008258	motif II; other site
568819008259	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
568819008260	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013
568819008261	putative active site [active]
568819008262	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
568819008263	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819008264	active site
568819008265	phosphorylation site [posttranslational modification]
568819008266	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569
568819008267	P-loop; other site
568819008268	active site
568819008269	phosphorylation site [posttranslational modification]
568819008270	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
568819008271	alpha-mannosidase; Provisional; Region: PRK09819
568819008272	Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074
568819008273	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
568819008274	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
568819008275	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
568819008276	Glycerate kinase family; Region: Gly_kinase; cl00841
568819008277	Transcriptional regulators [Transcription]; Region: PurR; COG1609
568819008278	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568819008279	DNA binding site [nucleotide binding]
568819008280	domain linker motif; other site
568819008281	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
568819008282	putative dimerization interface [polypeptide binding]; other site
568819008283	putative ligand binding site [chemical binding]; other site
568819008284	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
568819008285	Domain of unknown function DUF21; Region: DUF21; pfam01595
568819008286	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
568819008287	Transporter associated domain; Region: CorC_HlyC; cl08393
568819008288	SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411
568819008289	NAD+ binding site [chemical binding]; other site
568819008290	substrate binding site [chemical binding]; other site
568819008291	putative Zn binding site [ion binding]; other site
568819008292	TfoX N-terminal domain; Region: TfoX_N; cl01167
568819008293	drug efflux system protein MdtG; Provisional; Region: PRK09874
568819008294	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819008295	putative substrate translocation pore; other site
568819008296	RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; Region: RING; cl15255
568819008297	RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; Region: RING; cl15255
568819008298	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
568819008299	active site
568819008300	intersubunit interactions; other site
568819008301	catalytic residue [active]
568819008302	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568819008303	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
568819008304	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
568819008305	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
568819008306	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819008307	Walker A/P-loop; other site
568819008308	ATP binding site [chemical binding]; other site
568819008309	Q-loop/lid; other site
568819008310	ABC transporter signature motif; other site
568819008311	Walker B; other site
568819008312	D-loop; other site
568819008313	H-loop/switch region; other site
568819008314	TfoX N-terminal domain; Region: TfoX_N; cl01167
568819008315	seryl-tRNA synthetase; Provisional; Region: PRK05431
568819008316	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
568819008317	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
568819008318	dimer interface [polypeptide binding]; other site
568819008319	active site
568819008320	motif 1; other site
568819008321	motif 2; other site
568819008322	motif 3; other site
568819008323	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
568819008324	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
568819008325	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
568819008326	Glutamine amidotransferase class-I; Region: GATase; pfam00117
568819008327	glutamine binding [chemical binding]; other site
568819008328	catalytic triad [active]
568819008329	aminodeoxychorismate synthase; Provisional; Region: PRK07508
568819008330	chorismate binding enzyme; Region: Chorismate_bind; cl10555
568819008331	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224
568819008332	substrate-cofactor binding pocket; other site
568819008333	homodimer interface [polypeptide binding]; other site
568819008334	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819008335	catalytic residue [active]
568819008336	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
568819008337	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
568819008338	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819008339	Walker A/P-loop; other site
568819008340	ATP binding site [chemical binding]; other site
568819008341	Q-loop/lid; other site
568819008342	ABC transporter signature motif; other site
568819008343	Walker B; other site
568819008344	D-loop; other site
568819008345	H-loop/switch region; other site
568819008346	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
568819008347	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
568819008348	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
568819008349	Walker A/P-loop; other site
568819008350	ATP binding site [chemical binding]; other site
568819008351	Q-loop/lid; other site
568819008352	ABC transporter signature motif; other site
568819008353	Walker B; other site
568819008354	D-loop; other site
568819008355	H-loop/switch region; other site
568819008356	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961
568819008357	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
568819008358	Ligand binding site [chemical binding]; other site
568819008359	Putative Catalytic site [active]
568819008360	DXD motif; other site
568819008361	Beta-lactamase; Region: Beta-lactamase; cl01009
568819008362	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
568819008363	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814
568819008364	Predicted acyl esterases [General function prediction only]; Region: COG2936
568819008365	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
568819008366	DNA topoisomerase III; Provisional; Region: PRK07726
568819008367	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by:...; Region: TOPRIM_TopoIA_TopoIII; cd03362
568819008368	active site
568819008369	putative interdomain interaction site [polypeptide binding]; other site
568819008370	putative metal-binding site [ion binding]; other site
568819008371	putative nucleotide binding site [chemical binding]; other site
568819008372	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186
568819008373	domain I; other site
568819008374	DNA binding groove [nucleotide binding]
568819008375	phosphate binding site [ion binding]; other site
568819008376	domain II; other site
568819008377	domain III; other site
568819008378	nucleotide binding site [chemical binding]; other site
568819008379	catalytic site [active]
568819008380	domain IV; other site
568819008381	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
568819008382	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
568819008383	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
568819008384	ATP binding site [chemical binding]; other site
568819008385	putative Mg++ binding site [ion binding]; other site
568819008386	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568819008387	nucleotide binding region [chemical binding]; other site
568819008388	ATP-binding site [chemical binding]; other site
568819008389	RQC domain; Region: RQC; cl09632
568819008390	HRDC domain; Region: HRDC; cl02578
568819008391	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
568819008392	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
568819008393	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601
568819008394	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381
568819008395	active site
568819008396	Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908
568819008397	putative ADP-ribose binding site [chemical binding]; other site
568819008398	putative active site [active]
568819008399	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
568819008400	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
568819008401	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
568819008402	ABC transporter; Region: ABC_tran_2; pfam12848
568819008403	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
568819008404	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046
568819008405	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
568819008406	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564
568819008407	active site
568819008408	P-loop; other site
568819008409	phosphorylation site [posttranslational modification]
568819008410	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
568819008411	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
568819008412	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
568819008413	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
568819008414	methionine cluster; other site
568819008415	active site
568819008416	phosphorylation site [posttranslational modification]
568819008417	metal binding site [ion binding]; metal-binding site
568819008418	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
568819008419	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
568819008420	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013
568819008421	putative active site [active]
568819008422	Protein of unknown function (DUF1129); Region: DUF1129; cl11555
568819008423	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
568819008424	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
568819008425	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
568819008426	Walker A/P-loop; other site
568819008427	ATP binding site [chemical binding]; other site
568819008428	Q-loop/lid; other site
568819008429	ABC transporter signature motif; other site
568819008430	Walker B; other site
568819008431	D-loop; other site
568819008432	H-loop/switch region; other site
568819008433	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl01099
568819008434	bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471
568819008435	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
568819008436	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046
568819008437	6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593
568819008438	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
568819008439	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212
568819008440	active site turn [active]
568819008441	phosphorylation site [posttranslational modification]
568819008442	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
568819008443	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cd00210
568819008444	HPr interaction site; other site
568819008445	glycerol kinase (GK) interaction site [polypeptide binding]; other site
568819008446	active site
568819008447	phosphorylation site [posttranslational modification]
568819008448	transcriptional antiterminator BglG; Provisional; Region: PRK09772
568819008449	CAT RNA binding domain; Region: CAT_RBD; cl03904
568819008450	PRD domain; Region: PRD; pfam00874
568819008451	PRD domain; Region: PRD; pfam00874
568819008452	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
568819008453	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
568819008454	Walker A/P-loop; other site
568819008455	ATP binding site [chemical binding]; other site
568819008456	Q-loop/lid; other site
568819008457	ABC transporter signature motif; other site
568819008458	Walker B; other site
568819008459	D-loop; other site
568819008460	H-loop/switch region; other site
568819008461	bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654
568819008462	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
568819008463	Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891
568819008464	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
568819008465	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819008466	putative substrate translocation pore; other site
568819008467	GTP-binding protein YchF; Reviewed; Region: PRK09601
568819008468	YchF subfamily.  YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1.  Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900
568819008469	G1 box; other site
568819008470	GTP/Mg2+ binding site [chemical binding]; other site
568819008471	Switch I region; other site
568819008472	G2 box; other site
568819008473	Switch II region; other site
568819008474	G3 box; other site
568819008475	G4 box; other site
568819008476	G5 box; other site
568819008477	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
568819008478	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
568819008479	methionine cluster; other site
568819008480	active site
568819008481	phosphorylation site [posttranslational modification]
568819008482	metal binding site [ion binding]; metal-binding site
568819008483	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
568819008484	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
568819008485	Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915
568819008486	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564
568819008487	active site
568819008488	P-loop; other site
568819008489	phosphorylation site [posttranslational modification]
568819008490	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
568819008491	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
568819008492	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819008493	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819008494	PRD domain; Region: PRD; pfam00874
568819008495	PRD domain; Region: PRD; pfam00874
568819008496	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
568819008497	P-loop; other site
568819008498	active site
568819008499	phosphorylation site [posttranslational modification]
568819008500	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819008501	active site
568819008502	phosphorylation site [posttranslational modification]
568819008503	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
568819008504	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
568819008505	tetramer interface [polypeptide binding]; other site
568819008506	heme binding pocket [chemical binding]; other site
568819008507	Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864
568819008508	ParB-like partition proteins; Region: parB_part; TIGR00180
568819008509	ParB-like nuclease domain; Region: ParBc; cl02129
568819008510	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
568819008511	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
568819008512	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
568819008513	P-loop; other site
568819008514	Magnesium ion binding site [ion binding]; other site
568819008515	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
568819008516	Magnesium ion binding site [ion binding]; other site
568819008517	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
568819008518	ParB-like partition proteins; Region: parB_part; TIGR00180
568819008519	ParB-like nuclease domain; Region: ParBc; cl02129
568819008520	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
568819008521	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013
568819008522	putative active site [active]
568819008523	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
568819008524	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
568819008525	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819008526	active site
568819008527	phosphorylation site [posttranslational modification]
568819008528	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
568819008529	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
568819008530	motif II; other site
568819008531	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
568819008532	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
568819008533	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_mannitol; cd05567
568819008534	active site
568819008535	P-loop; other site
568819008536	phosphorylation site [posttranslational modification]
568819008537	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
568819008538	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819008539	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
568819008540	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family...; Region: NanE; cd04729
568819008541	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
568819008542	putative active site cavity [active]
568819008543	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
568819008544	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
568819008545	S-adenosylmethionine binding site [chemical binding]; other site
568819008546	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
568819008547	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
568819008548	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
568819008549	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
568819008550	Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445
568819008551	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819008552	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
568819008553	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
568819008554	TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes.  It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes.  TrmE contains a GTPase...; Region: trmE; cd04164
568819008555	G1 box; other site
568819008556	GTP/Mg2+ binding site [chemical binding]; other site
568819008557	Switch I region; other site
568819008558	G2 box; other site
568819008559	Switch II region; other site
568819008560	G3 box; other site
568819008561	G4 box; other site
568819008562	G5 box; other site
568819008563	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
568819008564	Beta-lactamase; Region: Beta-lactamase; cl01009
568819008565	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
568819008566	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568819008567	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
568819008568	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
568819008569	NADP binding site [chemical binding]; other site
568819008570	homodimer interface [polypeptide binding]; other site
568819008571	active site
568819008572	substrate binding site [chemical binding]; other site
568819008573	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819008574	D-galactonate transporter; Region: 2A0114; TIGR00893
568819008575	putative substrate translocation pore; other site
568819008576	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
568819008577	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
568819008578	metal binding site [ion binding]; metal-binding site
568819008579	dimer interface [polypeptide binding]; other site
568819008580	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
568819008581	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
568819008582	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
568819008583	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
568819008584	metal binding site [ion binding]; metal-binding site
568819008585	dimer interface [polypeptide binding]; other site
568819008586	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
568819008587	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568819008588	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; cl10042
568819008589	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309
568819008590	Leucine-rich repeats; other site
568819008591	Substrate binding site [chemical binding]; other site
568819008592	MucBP domain; Region: MucBP; pfam06458
568819008593	MucBP domain; Region: MucBP; pfam06458
568819008594	Protein of unknown function (DUF1015); Region: DUF1015; cl01715
568819008595	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
568819008596	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819008597	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
568819008598	L-serine binding site [chemical binding]; other site
568819008599	ACT domain interface; other site
568819008600	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
568819008601	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
568819008602	catalytic residue [active]
568819008603	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819008604	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568819008605	putative substrate translocation pore; other site
568819008606	Transcriptional regulators [Transcription]; Region: MarR; COG1846
568819008607	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
568819008608	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
568819008609	dimer interface [polypeptide binding]; other site
568819008610	FMN binding site [chemical binding]; other site
568819008611	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
568819008612	catalytic residues [active]
568819008613	beta-phosphoglucomutase; Region: bPGM; TIGR01990
568819008614	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
568819008615	motif II; other site
568819008616	Glycerate kinase family; Region: Gly_kinase; cl00841
568819008617	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
568819008618	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
568819008619	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
568819008620	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
568819008621	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819008622	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
568819008623	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
568819008624	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
568819008625	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
568819008626	putative NAD(P) binding site [chemical binding]; other site
568819008627	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
568819008628	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819008629	dimer interface [polypeptide binding]; other site
568819008630	conserved gate region; other site
568819008631	putative PBP binding loops; other site
568819008632	ABC-ATPase subunit interface; other site
568819008633	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
568819008634	dimer interface [polypeptide binding]; other site
568819008635	conserved gate region; other site
568819008636	putative PBP binding loops; other site
568819008637	ABC-ATPase subunit interface; other site
568819008638	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
568819008639	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
568819008640	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
568819008641	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
568819008642	Transcriptional regulators [Transcription]; Region: PurR; COG1609
568819008643	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568819008644	DNA binding site [nucleotide binding]
568819008645	domain linker motif; other site
568819008646	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
568819008647	putative dimerization interface [polypeptide binding]; other site
568819008648	putative ligand binding site [chemical binding]; other site
568819008649	Domain of Unknown Function with PDB structure; Region: DUF3857; pfam12969
568819008650	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
568819008651	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
568819008652	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819008653	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568819008654	putative substrate translocation pore; other site
568819008655	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819008656	Domain of unknown function (DUF718); Region: DUF718; cl01281
568819008657	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214
568819008658	intersubunit interface [polypeptide binding]; other site
568819008659	active site
568819008660	Zn2+ binding site [ion binding]; other site
568819008661	L-rhamnose isomerase (RhaA); Region: RhaA; cl09945
568819008662	L-rhamnulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
568819008663	N- and C-terminal domain interface [polypeptide binding]; other site
568819008664	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
568819008665	active site
568819008666	catalytic site [active]
568819008667	metal binding site [ion binding]; metal-binding site
568819008668	ATP binding site [chemical binding]; other site
568819008669	carbohydrate binding site [chemical binding]; other site
568819008670	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819008671	putative substrate translocation pore; other site
568819008672	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568819008673	Cupin domain; Region: Cupin_2; cl09118
568819008674	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
568819008675	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
568819008676	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
568819008677	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
568819008678	G-X-X-G motif; other site
568819008679	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
568819008680	RxxxH motif; other site
568819008681	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
568819008682	Ribonuclease P; Region: Ribonuclease_P; cl00457