-- dump date 20120504_151913 -- class Genbank::misc_feature -- table misc_feature_note -- id note 526227000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 526227000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 526227000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227000004 Walker A motif; other site 526227000005 ATP binding site [chemical binding]; other site 526227000006 Walker B motif; other site 526227000007 arginine finger; other site 526227000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 526227000009 DnaA box-binding interface [nucleotide binding]; other site 526227000010 DNA polymerase III subunit beta; Provisional; Region: PRK14945 526227000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 526227000012 putative DNA binding surface [nucleotide binding]; other site 526227000013 dimer interface [polypeptide binding]; other site 526227000014 beta-clamp/clamp loader binding surface; other site 526227000015 beta-clamp/translesion DNA polymerase binding surface; other site 526227000016 enolase; Provisional; Region: eno; PRK00077 526227000017 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 526227000018 dimer interface [polypeptide binding]; other site 526227000019 metal binding site [ion binding]; metal-binding site 526227000020 substrate binding pocket [chemical binding]; other site 526227000021 pyruvate kinase; Provisional; Region: PRK06247 526227000022 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 526227000023 domain interfaces; other site 526227000024 active site 526227000025 Cytochrome P450; Region: p450; pfam00067 526227000026 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 526227000027 putative transposase OrfB; Reviewed; Region: PHA02517 526227000028 Integrase core domain; Region: rve; cl01316 526227000029 Integrase core domain; Region: rve_3; cl15866 526227000030 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227000031 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227000032 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 526227000033 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526227000034 MULE transposase domain; Region: MULE; pfam10551 526227000035 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 526227000036 Nitrogen regulatory protein P-II; Region: P-II; cl00412 526227000037 Nitrogen regulatory protein P-II; Region: P-II; smart00938 526227000038 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 526227000039 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 526227000040 Helix-turn-helix domains; Region: HTH; cl00088 526227000041 HrcA protein C terminal domain; Region: HrcA; pfam01628 526227000042 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 526227000043 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 526227000044 substrate binding pocket [chemical binding]; other site 526227000045 chain length determination region; other site 526227000046 substrate-Mg2+ binding site; other site 526227000047 catalytic residues [active] 526227000048 aspartate-rich region 1; other site 526227000049 active site lid residues [active] 526227000050 aspartate-rich region 2; other site 526227000051 PspA/IM30 family; Region: PspA_IM30; pfam04012 526227000052 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227000053 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227000054 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 526227000055 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 526227000056 TPP-binding site; other site 526227000057 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 526227000058 PYR/PP interface [polypeptide binding]; other site 526227000059 dimer interface [polypeptide binding]; other site 526227000060 TPP binding site [chemical binding]; other site 526227000061 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 526227000062 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 526227000063 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 526227000064 Putative zinc ribbon domain; Region: DUF164; pfam02591 526227000065 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 526227000066 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 526227000067 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 526227000068 active site 526227000069 tetramer interface [polypeptide binding]; other site 526227000070 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 526227000071 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 526227000072 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 526227000073 putative active site [active] 526227000074 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 526227000075 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 526227000076 putative [4Fe-4S] binding site [ion binding]; other site 526227000077 putative molybdopterin cofactor binding site [chemical binding]; other site 526227000078 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 526227000079 putative molybdopterin cofactor binding site; other site 526227000080 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 526227000081 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 526227000082 Arginine degradation protein (predicted deacylase) [Amino acid transport and metabolism]; Region: RocB; COG4187 526227000083 metal binding site [ion binding]; metal-binding site 526227000084 primosome assembly protein PriA; Validated; Region: PRK05580 526227000085 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 526227000086 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 526227000087 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 526227000088 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 526227000089 Walker A/P-loop; other site 526227000090 ATP binding site [chemical binding]; other site 526227000091 Q-loop/lid; other site 526227000092 ABC transporter signature motif; other site 526227000093 Walker B; other site 526227000094 D-loop; other site 526227000095 H-loop/switch region; other site 526227000096 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 526227000097 TM-ABC transporter signature motif; other site 526227000098 D-allose transporter subunit; Provisional; Region: PRK09701 526227000099 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 526227000100 Transcriptional regulators [Transcription]; Region: PurR; COG1609 526227000101 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 526227000102 DNA binding site [nucleotide binding] 526227000103 domain linker motif; other site 526227000104 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 526227000105 dimerization interface [polypeptide binding]; other site 526227000106 ligand binding site [chemical binding]; other site 526227000107 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 526227000108 homodimer interface [polypeptide binding]; other site 526227000109 substrate-cofactor binding pocket; other site 526227000110 catalytic residue [active] 526227000111 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 526227000112 ATP cone domain; Region: ATP-cone; pfam03477 526227000113 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227000114 NAD(P) binding site [chemical binding]; other site 526227000115 active site 526227000116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227000117 S-adenosylmethionine binding site [chemical binding]; other site 526227000118 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526227000119 Coenzyme A binding pocket [chemical binding]; other site 526227000120 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 526227000121 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 526227000122 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 526227000123 active site 526227000124 metal binding site [ion binding]; metal-binding site 526227000125 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 526227000126 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 526227000127 putative ADP-ribose binding site [chemical binding]; other site 526227000128 recombination protein F; Provisional; Region: recF; PRK14079 526227000129 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227000130 Walker A/P-loop; other site 526227000131 ATP binding site [chemical binding]; other site 526227000132 Q-loop/lid; other site 526227000133 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227000134 ABC transporter signature motif; other site 526227000135 Walker B; other site 526227000136 D-loop; other site 526227000137 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 526227000138 Protein of unknown function (DUF721); Region: DUF721; cl02324 526227000139 Protein of unknown function DUF45; Region: DUF45; cl00636 526227000140 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 526227000141 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 526227000142 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 526227000143 short chain dehydrogenase; Provisional; Region: PRK12827 526227000144 classical (c) SDRs; Region: SDR_c; cd05233 526227000145 NAD(P) binding site [chemical binding]; other site 526227000146 active site 526227000147 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526227000148 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 526227000149 active site 526227000150 metal binding site [ion binding]; metal-binding site 526227000151 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 526227000152 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 526227000153 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 526227000154 GAF domain; Region: GAF_2; pfam13185 526227000155 GAF domain; Region: GAF; cl15785 526227000156 Histidine kinase; Region: HisKA_3; pfam07730 526227000157 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227000158 ATP binding site [chemical binding]; other site 526227000159 Mg2+ binding site [ion binding]; other site 526227000160 G-X-G motif; other site 526227000161 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526227000162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227000163 active site 526227000164 phosphorylation site [posttranslational modification] 526227000165 intermolecular recognition site; other site 526227000166 dimerization interface [polypeptide binding]; other site 526227000167 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526227000168 DNA binding residues [nucleotide binding] 526227000169 dimerization interface [polypeptide binding]; other site 526227000170 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 526227000171 RNA binding site [nucleotide binding]; other site 526227000172 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 526227000173 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526227000174 active site 526227000175 Protein of unknown function (DUF692); Region: DUF692; cl01263 526227000176 threonine dehydratase; Provisional; Region: PRK08198 526227000177 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 526227000178 tetramer interface [polypeptide binding]; other site 526227000179 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227000180 catalytic residue [active] 526227000181 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 526227000182 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 526227000183 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 526227000184 dimer interface [polypeptide binding]; other site 526227000185 putative functional site; other site 526227000186 putative MPT binding site; other site 526227000187 ATP phosphoribosyltransferase; Region: HisG; cl15266 526227000188 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 526227000189 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 526227000190 active site 526227000191 catalytic tetrad [active] 526227000192 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 526227000193 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 526227000194 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 526227000195 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 526227000196 VanW like protein; Region: VanW; pfam04294 526227000197 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 526227000198 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 526227000199 metal binding site [ion binding]; metal-binding site 526227000200 dimer interface [polypeptide binding]; other site 526227000201 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 526227000202 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 526227000203 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 526227000204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 526227000205 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 526227000206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227000207 putative PBP binding loops; other site 526227000208 dimer interface [polypeptide binding]; other site 526227000209 ABC-ATPase subunit interface; other site 526227000210 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 526227000211 classical (c) SDRs; Region: SDR_c; cd05233 526227000212 NAD(P) binding site [chemical binding]; other site 526227000213 active site 526227000214 Sulfatase; Region: Sulfatase; cl10460 526227000215 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 526227000216 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 526227000217 active site residue [active] 526227000218 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 526227000219 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 526227000220 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 526227000221 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 526227000222 Peptidase S8 family domain, uncharacterized subfamily 5; Region: Peptidases_S8_5; cd07489 526227000223 active site 526227000224 catalytic triad [active] 526227000225 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 526227000226 PA/protease or protease-like domain interface [polypeptide binding]; other site 526227000227 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 526227000228 catalytic residues [active] 526227000229 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 526227000230 DDE superfamily endonuclease; Region: DDE_4; cl15789 526227000231 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227000232 DDE superfamily endonuclease; Region: DDE_4; cl15789 526227000233 putative transposase OrfB; Reviewed; Region: PHA02517 526227000234 Integrase core domain; Region: rve; cl01316 526227000235 Integrase core domain; Region: rve_3; cl15866 526227000236 prolyl-tRNA synthetase; Provisional; Region: PRK08661 526227000237 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_arch_euk; cd00778 526227000238 dimer interface [polypeptide binding]; other site 526227000239 motif 1; other site 526227000240 active site 526227000241 motif 2; other site 526227000242 motif 3; other site 526227000243 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 526227000244 anticodon binding site; other site 526227000245 zinc-binding site [ion binding]; other site 526227000246 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 526227000247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227000248 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 526227000249 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 526227000250 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 526227000251 minor groove reading motif; other site 526227000252 helix-hairpin-helix signature motif; other site 526227000253 substrate binding pocket [chemical binding]; other site 526227000254 active site 526227000255 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 526227000256 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227000257 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526227000258 putative substrate translocation pore; other site 526227000259 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 526227000260 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 526227000261 AMP-binding enzyme; Region: AMP-binding; cl15778 526227000262 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 526227000263 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 526227000264 active site 526227000265 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 526227000266 folate binding site [chemical binding]; other site 526227000267 NADP+ binding site [chemical binding]; other site 526227000268 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 526227000269 dimerization interface [polypeptide binding]; other site 526227000270 active site 526227000271 S-layer homology domain; Region: SLH; pfam00395 526227000272 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 526227000273 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 526227000274 FOG: CBS domain [General function prediction only]; Region: COG0517 526227000275 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 526227000276 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 526227000277 Ligand Binding Site [chemical binding]; other site 526227000278 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 526227000279 Ligand Binding Site [chemical binding]; other site 526227000280 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526227000281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227000282 putative substrate translocation pore; other site 526227000283 SurA N-terminal domain; Region: SurA_N_3; cl07813 526227000284 PPIC-type PPIASE domain; Region: Rotamase; cl08278 526227000285 PPIC-type PPIASE domain; Region: Rotamase; cl08278 526227000286 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 526227000287 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 526227000288 glutaminase active site [active] 526227000289 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 526227000290 dimer interface [polypeptide binding]; other site 526227000291 active site 526227000292 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 526227000293 dimer interface [polypeptide binding]; other site 526227000294 active site 526227000295 S-layer homology domain; Region: SLH; pfam00395 526227000296 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 526227000297 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 526227000298 putative active site [active] 526227000299 excinuclease ABC subunit B; Provisional; Region: PRK05298 526227000300 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526227000301 ATP binding site [chemical binding]; other site 526227000302 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526227000303 nucleotide binding region [chemical binding]; other site 526227000304 ATP-binding site [chemical binding]; other site 526227000305 Ultra-violet resistance protein B; Region: UvrB; pfam12344 526227000306 UvrB/uvrC motif; Region: UVR; pfam02151 526227000307 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 526227000308 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 526227000309 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 526227000310 e3 binding domain; Region: E3_binding; pfam02817 526227000311 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 526227000312 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 526227000313 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 526227000314 putative NAD(P) binding site [chemical binding]; other site 526227000315 putative substrate binding site [chemical binding]; other site 526227000316 catalytic Zn binding site [ion binding]; other site 526227000317 structural Zn binding site [ion binding]; other site 526227000318 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 526227000319 RNA binding site [nucleotide binding]; other site 526227000320 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 526227000321 RNA binding site [nucleotide binding]; other site 526227000322 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 526227000323 RNA binding site [nucleotide binding]; other site 526227000324 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec5; cd05690 526227000325 RNA binding site [nucleotide binding]; other site 526227000326 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec5; cd05690 526227000327 RNA binding site [nucleotide binding]; other site 526227000328 putative transposase OrfB; Reviewed; Region: PHA02517 526227000329 Integrase core domain; Region: rve; cl01316 526227000330 Integrase core domain; Region: rve_3; cl15866 526227000331 FOG: CBS domain [General function prediction only]; Region: COG0517 526227000332 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 526227000333 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 526227000334 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 526227000335 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227000336 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 526227000337 putative peptidoglycan binding site; other site 526227000338 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 526227000339 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 526227000340 putative peptidoglycan binding site; other site 526227000341 NlpC/P60 family; Region: NLPC_P60; cl11438 526227000342 cytidylate kinase; Provisional; Region: cmk; PRK00023 526227000343 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 526227000344 CMP-binding site; other site 526227000345 The sites determining sugar specificity; other site 526227000346 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227000347 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227000348 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 526227000349 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 526227000350 hinge; other site 526227000351 active site 526227000352 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 526227000353 DHH family; Region: DHH; pfam01368 526227000354 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 526227000355 active site 526227000356 multimer interface [polypeptide binding]; other site 526227000357 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 526227000358 Catalytic domain of Protein Kinases; Region: PKc; cd00180 526227000359 active site 526227000360 ATP binding site [chemical binding]; other site 526227000361 substrate binding site [chemical binding]; other site 526227000362 activation loop (A-loop); other site 526227000363 PQQ-like domain; Region: PQQ_2; pfam13360 526227000364 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 526227000365 Trp docking motif [polypeptide binding]; other site 526227000366 active site 526227000367 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 526227000368 metal-binding site [ion binding] 526227000369 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 526227000370 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 526227000371 metal-binding site [ion binding] 526227000372 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 526227000373 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526227000374 motif II; other site 526227000375 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 526227000376 putative homodimer interface [polypeptide binding]; other site 526227000377 putative homotetramer interface [polypeptide binding]; other site 526227000378 allosteric switch controlling residues; other site 526227000379 putative metal binding site [ion binding]; other site 526227000380 putative homodimer-homodimer interface [polypeptide binding]; other site 526227000381 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 526227000382 metal-binding site [ion binding] 526227000383 Domain of unknown function (DUF305); Region: DUF305; cl15795 526227000384 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 526227000385 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 526227000386 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 526227000387 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526227000388 motif II; other site 526227000389 Short C-terminal domain; Region: SHOCT; cl01373 526227000390 Domain of unknown function DUF302; Region: DUF302; cl01364 526227000391 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 526227000392 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 526227000393 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 526227000394 Protein of unknown function, DUF; Region: DUF411; cl01142 526227000395 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 526227000396 dimerization interface [polypeptide binding]; other site 526227000397 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526227000398 dimer interface [polypeptide binding]; other site 526227000399 phosphorylation site [posttranslational modification] 526227000400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227000401 ATP binding site [chemical binding]; other site 526227000402 Mg2+ binding site [ion binding]; other site 526227000403 G-X-G motif; other site 526227000404 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526227000405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227000406 active site 526227000407 phosphorylation site [posttranslational modification] 526227000408 intermolecular recognition site; other site 526227000409 dimerization interface [polypeptide binding]; other site 526227000410 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526227000411 DNA binding site [nucleotide binding] 526227000412 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 526227000413 CCC1; Region: CCC1; cd02435 526227000414 EamA-like transporter family; Region: EamA; cl01037 526227000415 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 526227000416 EamA-like transporter family; Region: EamA; cl01037 526227000417 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 526227000418 catalytic residues [active] 526227000419 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227000420 binding surface 526227000421 TPR motif; other site 526227000422 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227000423 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227000424 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227000425 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526227000426 metal binding site [ion binding]; metal-binding site 526227000427 active site 526227000428 I-site; other site 526227000429 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 526227000430 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227000431 Walker A motif; other site 526227000432 ATP binding site [chemical binding]; other site 526227000433 Walker B motif; other site 526227000434 arginine finger; other site 526227000435 Sulfatase; Region: Sulfatase; cl10460 526227000436 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 526227000437 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 526227000438 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 526227000439 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 526227000440 NAD(P) binding site [chemical binding]; other site 526227000441 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227000442 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 526227000443 NAD(P) binding site [chemical binding]; other site 526227000444 active site 526227000445 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 526227000446 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 526227000447 putative NAD(P) binding site [chemical binding]; other site 526227000448 catalytic Zn binding site [ion binding]; other site 526227000449 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 526227000450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 526227000451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 526227000452 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 526227000453 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227000454 Transcriptional regulators [Transcription]; Region: PurR; COG1609 526227000455 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 526227000456 DNA binding site [nucleotide binding] 526227000457 domain linker motif; other site 526227000458 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 526227000459 dimerization interface [polypeptide binding]; other site 526227000460 ligand binding site [chemical binding]; other site 526227000461 Uncharacterized conserved protein [Function unknown]; Region: COG1624 526227000462 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 526227000463 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 526227000464 active site 526227000465 catalytic residues [active] 526227000466 metal binding site [ion binding]; metal-binding site 526227000467 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 526227000468 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 526227000469 putative active site [active] 526227000470 substrate binding site [chemical binding]; other site 526227000471 putative cosubstrate binding site; other site 526227000472 catalytic site [active] 526227000473 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 526227000474 substrate binding site [chemical binding]; other site 526227000475 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 526227000476 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 526227000477 CPxP motif; other site 526227000478 DsrE/DsrF-like family; Region: DrsE; cl00672 526227000479 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 526227000480 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 526227000481 active site 526227000482 ADP/pyrophosphate binding site [chemical binding]; other site 526227000483 dimerization interface [polypeptide binding]; other site 526227000484 allosteric effector site; other site 526227000485 fructose-1,6-bisphosphate binding site; other site 526227000486 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 526227000487 DNA binding residues [nucleotide binding] 526227000488 dimer interface [polypeptide binding]; other site 526227000489 putative transposase OrfB; Reviewed; Region: PHA02517 526227000490 Integrase core domain; Region: rve; cl01316 526227000491 Integrase core domain; Region: rve_3; cl15866 526227000492 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 526227000493 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 526227000494 GDP-binding site [chemical binding]; other site 526227000495 ACT binding site; other site 526227000496 IMP binding site; other site 526227000497 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 526227000498 putative active site [active] 526227000499 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 526227000500 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 526227000501 G1 box; other site 526227000502 putative GEF interaction site [polypeptide binding]; other site 526227000503 GTP/Mg2+ binding site [chemical binding]; other site 526227000504 Switch I region; other site 526227000505 G2 box; other site 526227000506 G3 box; other site 526227000507 Switch II region; other site 526227000508 G4 box; other site 526227000509 G5 box; other site 526227000510 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 526227000511 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 526227000512 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 526227000513 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 526227000514 Protein of unknown function (DUF525); Region: DUF525; cl01119 526227000515 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 526227000516 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 526227000517 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526227000518 motif II; other site 526227000519 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 526227000520 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 526227000521 substrate binding pocket [chemical binding]; other site 526227000522 membrane-bound complex binding site; other site 526227000523 hinge residues; other site 526227000524 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 526227000525 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 526227000526 Walker A/P-loop; other site 526227000527 ATP binding site [chemical binding]; other site 526227000528 Q-loop/lid; other site 526227000529 ABC transporter signature motif; other site 526227000530 Walker B; other site 526227000531 D-loop; other site 526227000532 H-loop/switch region; other site 526227000533 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 526227000534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227000535 dimer interface [polypeptide binding]; other site 526227000536 conserved gate region; other site 526227000537 ABC-ATPase subunit interface; other site 526227000538 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 526227000539 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227000540 Walker A/P-loop; other site 526227000541 ATP binding site [chemical binding]; other site 526227000542 Q-loop/lid; other site 526227000543 ABC transporter signature motif; other site 526227000544 Walker B; other site 526227000545 D-loop; other site 526227000546 H-loop/switch region; other site 526227000547 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 526227000548 TM-ABC transporter signature motif; other site 526227000549 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227000550 Transcriptional regulators [Transcription]; Region: PurR; COG1609 526227000551 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 526227000552 DNA binding site [nucleotide binding] 526227000553 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 526227000554 ligand binding site [chemical binding]; other site 526227000555 dimerization interface [polypeptide binding]; other site 526227000556 Uncharacterized conserved protein [Function unknown]; Region: COG3391 526227000557 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 526227000558 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 526227000559 hydroxyglutarate oxidase; Provisional; Region: PRK11728 526227000560 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227000561 Peptidase family M23; Region: Peptidase_M23; pfam01551 526227000562 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 526227000563 Peptidase family M23; Region: Peptidase_M23; pfam01551 526227000564 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 526227000565 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 526227000566 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 526227000567 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 526227000568 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 526227000569 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 526227000570 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 526227000571 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526227000572 active site 526227000573 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 526227000574 4Fe-4S binding domain; Region: Fer4; cl02805 526227000575 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 526227000576 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 526227000577 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526227000578 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 526227000579 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526227000580 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 526227000581 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526227000582 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 526227000583 ATP-grasp domain; Region: ATP-grasp_4; cl03087 526227000584 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 526227000585 Putative esterase; Region: Esterase; pfam00756 526227000586 Cupin domain; Region: Cupin_2; cl09118 526227000587 falcipain-2; Provisional; Region: PTZ00021 526227000588 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 526227000589 active site 526227000590 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227000591 Predicted ATPase [General function prediction only]; Region: COG3899 526227000592 tetratricopeptide repeat protein; Provisional; Region: PRK11788 526227000593 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227000594 binding surface 526227000595 TPR motif; other site 526227000596 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227000597 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227000598 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 526227000599 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 526227000600 active site 526227000601 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 526227000602 Predicted ATPase [General function prediction only]; Region: COG3899 526227000603 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227000604 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 526227000605 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 526227000606 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 526227000607 Walker A/P-loop; other site 526227000608 ATP binding site [chemical binding]; other site 526227000609 Q-loop/lid; other site 526227000610 ABC transporter signature motif; other site 526227000611 Walker B; other site 526227000612 D-loop; other site 526227000613 H-loop/switch region; other site 526227000614 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 526227000615 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 526227000616 Flagellin N-methylase; Region: FliB; cl00497 526227000617 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 526227000618 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 526227000619 substrate binding site [chemical binding]; other site 526227000620 dimer interface [polypeptide binding]; other site 526227000621 ATP binding site [chemical binding]; other site 526227000622 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 526227000623 phosphate binding site [ion binding]; other site 526227000624 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 526227000625 putative active site [active] 526227000626 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 526227000627 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 526227000628 motif 1; other site 526227000629 active site 526227000630 motif 2; other site 526227000631 motif 3; other site 526227000632 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 526227000633 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 526227000634 YceG-like family; Region: YceG; pfam02618 526227000635 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 526227000636 dimerization interface [polypeptide binding]; other site 526227000637 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 526227000638 PhoD-like phosphatase; Region: PhoD; pfam09423 526227000639 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 526227000640 putative active site [active] 526227000641 putative metal binding site [ion binding]; other site 526227000642 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 526227000643 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 526227000644 Ligand Binding Site [chemical binding]; other site 526227000645 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 526227000646 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227000647 Walker A motif; other site 526227000648 ATP binding site [chemical binding]; other site 526227000649 Walker B motif; other site 526227000650 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 526227000651 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 526227000652 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 526227000653 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227000654 TPR motif; other site 526227000655 binding surface 526227000656 O-Antigen ligase; Region: Wzy_C; cl04850 526227000657 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 526227000658 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526227000659 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 526227000660 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 526227000661 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 526227000662 dimer interface [polypeptide binding]; other site 526227000663 active site 526227000664 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 526227000665 Substrate binding site; other site 526227000666 Mg++ binding site; other site 526227000667 metal-binding site 526227000668 Mg++ binding site; other site 526227000669 metal-binding site 526227000670 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 526227000671 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526227000672 active site 526227000673 motif I; other site 526227000674 motif II; other site 526227000675 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526227000676 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 526227000677 Bacterial transcriptional activator domain; Region: BTAD; smart01043 526227000678 Predicted ATPase [General function prediction only]; Region: COG3899 526227000679 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227000680 TPR motif; other site 526227000681 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227000682 binding surface 526227000683 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 526227000684 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 526227000685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227000686 putative substrate translocation pore; other site 526227000687 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 526227000688 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 526227000689 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 526227000690 4Fe-4S binding domain; Region: Fer4; cl02805 526227000691 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 526227000692 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 526227000693 [4Fe-4S] binding site [ion binding]; other site 526227000694 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 526227000695 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 526227000696 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 526227000697 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 526227000698 molybdopterin cofactor binding site; other site 526227000699 Cytochrome c; Region: Cytochrom_C; cl11414 526227000700 GAF domain; Region: GAF; cl15785 526227000701 Helix-turn-helix domains; Region: HTH; cl00088 526227000702 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 526227000703 DNA binding site [nucleotide binding] 526227000704 cyclase homology domain; Region: CHD; cd07302 526227000705 nucleotidyl binding site; other site 526227000706 metal binding site [ion binding]; metal-binding site 526227000707 dimer interface [polypeptide binding]; other site 526227000708 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 526227000709 cyclase homology domain; Region: CHD; cd07302 526227000710 dimer interface [polypeptide binding]; other site 526227000711 nucleotidyl binding site; other site 526227000712 metal binding site [ion binding]; metal-binding site 526227000713 Predicted ATPase [General function prediction only]; Region: COG3899 526227000714 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227000715 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227000716 TPR motif; other site 526227000717 binding surface 526227000718 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227000719 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227000720 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 526227000721 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 526227000722 ligand binding site [chemical binding]; other site 526227000723 flexible hinge region; other site 526227000724 Helix-turn-helix domains; Region: HTH; cl00088 526227000725 Cupin domain; Region: Cupin_2; cl09118 526227000726 YwiC-like protein; Region: YwiC; pfam14256 526227000727 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 526227000728 4Fe-4S binding domain; Region: Fer4; cl02805 526227000729 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 526227000730 4Fe-4S binding domain; Region: Fer4; cl02805 526227000731 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 526227000732 Domain of unknown function DUF59; Region: DUF59; cl00941 526227000733 Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445 526227000734 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 526227000735 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 526227000736 minor groove reading motif; other site 526227000737 helix-hairpin-helix signature motif; other site 526227000738 substrate binding pocket [chemical binding]; other site 526227000739 active site 526227000740 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 526227000741 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 526227000742 DNA binding and oxoG recognition site [nucleotide binding] 526227000743 Predicted integral membrane protein (DUF2270); Region: DUF2270; cl02337 526227000744 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227000745 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 526227000746 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 526227000747 active site 526227000748 metal binding site [ion binding]; metal-binding site 526227000749 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 526227000750 homodimer interface [polypeptide binding]; other site 526227000751 NAD synthase; Region: NAD_synthase; pfam02540 526227000752 NAD binding pocket [chemical binding]; other site 526227000753 ATP binding pocket [chemical binding]; other site 526227000754 Mg binding site [ion binding]; other site 526227000755 active-site loop [active] 526227000756 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 526227000757 active site 526227000758 catalytic triad [active] 526227000759 dimer interface [polypeptide binding]; other site 526227000760 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 526227000761 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 526227000762 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 526227000763 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 526227000764 NADP binding site [chemical binding]; other site 526227000765 dimer interface [polypeptide binding]; other site 526227000766 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 526227000767 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 526227000768 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 526227000769 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 526227000770 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 526227000771 putative active site [active] 526227000772 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 526227000773 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227000774 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 526227000775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227000776 dimer interface [polypeptide binding]; other site 526227000777 conserved gate region; other site 526227000778 putative PBP binding loops; other site 526227000779 ABC-ATPase subunit interface; other site 526227000780 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 526227000781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227000782 dimer interface [polypeptide binding]; other site 526227000783 conserved gate region; other site 526227000784 putative PBP binding loops; other site 526227000785 ABC-ATPase subunit interface; other site 526227000786 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 526227000787 Protein of unknown function (DUF4127); Region: DUF4127; pfam13552 526227000788 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 526227000789 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 526227000790 active site 526227000791 dimer interface [polypeptide binding]; other site 526227000792 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 526227000793 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 526227000794 dimer interface [polypeptide binding]; other site 526227000795 active site 526227000796 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 526227000797 dimer interface [polypeptide binding]; other site 526227000798 active site 526227000799 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 526227000800 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 526227000801 putative active site cavity [active] 526227000802 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 526227000803 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 526227000804 active site 526227000805 FMN binding site [chemical binding]; other site 526227000806 substrate binding site [chemical binding]; other site 526227000807 homotetramer interface [polypeptide binding]; other site 526227000808 catalytic residue [active] 526227000809 phosphoglucomutase; Validated; Region: PRK07564 526227000810 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 526227000811 active site 526227000812 substrate binding site [chemical binding]; other site 526227000813 metal binding site [ion binding]; metal-binding site 526227000814 Cupin domain; Region: Cupin_2; cl09118 526227000815 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526227000816 dimerization interface [polypeptide binding]; other site 526227000817 putative DNA binding site [nucleotide binding]; other site 526227000818 putative Zn2+ binding site [ion binding]; other site 526227000819 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 526227000820 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 526227000821 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526227000822 active site 526227000823 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 526227000824 Ligand binding site [chemical binding]; other site 526227000825 Electron transfer flavoprotein domain; Region: ETF; pfam01012 526227000826 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 526227000827 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 526227000828 Ligand Binding Site [chemical binding]; other site 526227000829 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 526227000830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227000831 putative substrate translocation pore; other site 526227000832 Helix-turn-helix domains; Region: HTH; cl00088 526227000833 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 526227000834 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 526227000835 Predicted transcriptional regulator [Transcription]; Region: COG2345 526227000836 Helix-turn-helix domains; Region: HTH; cl00088 526227000837 DinB superfamily; Region: DinB_2; pfam12867 526227000838 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 526227000839 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 526227000840 NAD binding site [chemical binding]; other site 526227000841 homotetramer interface [polypeptide binding]; other site 526227000842 homodimer interface [polypeptide binding]; other site 526227000843 substrate binding site [chemical binding]; other site 526227000844 active site 526227000845 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 526227000846 dihydropteroate synthase; Region: DHPS; TIGR01496 526227000847 substrate binding pocket [chemical binding]; other site 526227000848 dimer interface [polypeptide binding]; other site 526227000849 inhibitor binding site; inhibition site 526227000850 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 526227000851 homooctamer interface [polypeptide binding]; other site 526227000852 active site 526227000853 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 526227000854 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 526227000855 calcium binding site 2 [ion binding]; other site 526227000856 active site 526227000857 catalytic triad [active] 526227000858 calcium binding site 1 [ion binding]; other site 526227000859 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 526227000860 MOSC domain; Region: MOSC; pfam03473 526227000861 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227000862 Protein of unknown function DUF72; Region: DUF72; cl00777 526227000863 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227000864 S-adenosylmethionine binding site [chemical binding]; other site 526227000865 diaminopimelate decarboxylase; Region: lysA; TIGR01048 526227000866 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 526227000867 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 526227000868 catalytic residue [active] 526227000869 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 526227000870 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 526227000871 catalytic triad [active] 526227000872 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 526227000873 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 526227000874 putative transposase OrfB; Reviewed; Region: PHA02517 526227000875 Integrase core domain; Region: rve; cl01316 526227000876 Integrase core domain; Region: rve_3; cl15866 526227000877 Ribulose bisphosphate carboxylase like proteins (RLPs) similar to R.rubrum RLP; Region: RLP_RrRLP; cd08210 526227000878 dimer interface [polypeptide binding]; other site 526227000879 active site 526227000880 catalytic residue [active] 526227000881 metal binding site [ion binding]; metal-binding site 526227000882 Cupin domain; Region: Cupin_2; cl09118 526227000883 DNA polymerase IV; Reviewed; Region: PRK03103 526227000884 Y-family of DNA polymerases; Region: PolY; cd00424 526227000885 active site 526227000886 DNA binding site [nucleotide binding] 526227000887 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 526227000888 alanine racemase; Reviewed; Region: alr; PRK00053 526227000889 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 526227000890 active site 526227000891 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 526227000892 dimer interface [polypeptide binding]; other site 526227000893 substrate binding site [chemical binding]; other site 526227000894 catalytic residues [active] 526227000895 Protein of unknown function (DUF3208); Region: DUF3208; pfam11482 526227000896 DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626 526227000897 putative ligand binding site [chemical binding]; other site 526227000898 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 526227000899 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 526227000900 phosphate binding site [ion binding]; other site 526227000901 putative substrate binding pocket [chemical binding]; other site 526227000902 dimer interface [polypeptide binding]; other site 526227000903 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 526227000904 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 526227000905 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 526227000906 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14468 526227000907 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 526227000908 FeS/SAM binding site; other site 526227000909 GAF domain; Region: GAF; cl15785 526227000910 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526227000911 metal binding site [ion binding]; metal-binding site 526227000912 active site 526227000913 I-site; other site 526227000914 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 526227000915 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 526227000916 MoaE interaction surface [polypeptide binding]; other site 526227000917 MoeB interaction surface [polypeptide binding]; other site 526227000918 thiocarboxylated glycine; other site 526227000919 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 526227000920 MoaE homodimer interface [polypeptide binding]; other site 526227000921 MoaD interaction [polypeptide binding]; other site 526227000922 active site residues [active] 526227000923 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 526227000924 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227000925 ATP binding site [chemical binding]; other site 526227000926 Mg2+ binding site [ion binding]; other site 526227000927 G-X-G motif; other site 526227000928 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 526227000929 anchoring element; other site 526227000930 dimer interface [polypeptide binding]; other site 526227000931 ATP binding site [chemical binding]; other site 526227000932 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 526227000933 active site 526227000934 putative metal-binding site [ion binding]; other site 526227000935 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 526227000936 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 526227000937 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 526227000938 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 526227000939 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 526227000940 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 526227000941 Probable Catalytic site; other site 526227000942 metal-binding site 526227000943 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 526227000944 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 526227000945 active site 526227000946 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 526227000947 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526227000948 active site 526227000949 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 526227000950 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 526227000951 glutamine binding [chemical binding]; other site 526227000952 catalytic triad [active] 526227000953 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 526227000954 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 526227000955 chorismate binding enzyme; Region: Chorismate_bind; cl10555 526227000956 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 526227000957 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 526227000958 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526227000959 catalytic residue [active] 526227000960 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 526227000961 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 526227000962 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526227000963 metal binding site [ion binding]; metal-binding site 526227000964 active site 526227000965 I-site; other site 526227000966 M20 Peptidase acetylornithine deacetylase/acetyl-lysine deacetylase; Region: M20_ArgE_LysK; cd05653 526227000967 acetyl-lysine deacetylase; Validated; Region: PRK00466 526227000968 metal binding site [ion binding]; metal-binding site 526227000969 putative dimer interface [polypeptide binding]; other site 526227000970 acetylornithine aminotransferase; Provisional; Region: PRK02627 526227000971 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 526227000972 inhibitor-cofactor binding pocket; inhibition site 526227000973 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227000974 catalytic residue [active] 526227000975 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 526227000976 catalytic center binding site [active] 526227000977 ATP binding site [chemical binding]; other site 526227000978 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526227000979 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 526227000980 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 526227000981 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 526227000982 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 526227000983 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 526227000984 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 526227000985 metal binding site 2 [ion binding]; metal-binding site 526227000986 putative DNA binding helix; other site 526227000987 metal binding site 1 [ion binding]; metal-binding site 526227000988 dimer interface [polypeptide binding]; other site 526227000989 structural Zn2+ binding site [ion binding]; other site 526227000990 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 526227000991 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 526227000992 domain interfaces; other site 526227000993 active site 526227000994 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 526227000995 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 526227000996 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 526227000997 substrate binding site [chemical binding]; other site 526227000998 Restriction endonuclease; Region: Mrr_cat; cl00516 526227000999 Type III pantothenate kinase; Region: Pan_kinase; cl09130 526227001000 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 526227001001 Flavoprotein; Region: Flavoprotein; cl08021 526227001002 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 526227001003 Helix-turn-helix domains; Region: HTH; cl00088 526227001004 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 526227001005 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227001006 Walker A/P-loop; other site 526227001007 ATP binding site [chemical binding]; other site 526227001008 Q-loop/lid; other site 526227001009 ABC transporter signature motif; other site 526227001010 Walker B; other site 526227001011 D-loop; other site 526227001012 H-loop/switch region; other site 526227001013 S-layer homology domain; Region: SLH; pfam00395 526227001014 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 526227001015 dimer interface [polypeptide binding]; other site 526227001016 substrate binding site [chemical binding]; other site 526227001017 ATP binding site [chemical binding]; other site 526227001018 ThiC family; Region: ThiC; cl08031 526227001019 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 526227001020 ThiS interaction site; other site 526227001021 putative active site [active] 526227001022 tetramer interface [polypeptide binding]; other site 526227001023 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 526227001024 thiS-thiF/thiG interaction site; other site 526227001025 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 526227001026 thiamine phosphate binding site [chemical binding]; other site 526227001027 active site 526227001028 pyrophosphate binding site [ion binding]; other site 526227001029 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 526227001030 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 526227001031 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 526227001032 Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl01000 526227001033 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 526227001034 catalytic triad [active] 526227001035 putative active site [active] 526227001036 putative transposase OrfB; Reviewed; Region: PHA02517 526227001037 Integrase core domain; Region: rve; cl01316 526227001038 Integrase core domain; Region: rve_3; cl15866 526227001039 Integral membrane protein DUF92; Region: DUF92; cl00793 526227001040 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 526227001041 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 526227001042 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 526227001043 synthetase active site [active] 526227001044 NTP binding site [chemical binding]; other site 526227001045 metal binding site [ion binding]; metal-binding site 526227001046 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 526227001047 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 526227001048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227001049 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 526227001050 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 526227001051 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 526227001052 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 526227001053 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 526227001054 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 526227001055 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 526227001056 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 526227001057 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 526227001058 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 526227001059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227001060 Walker A motif; other site 526227001061 ATP binding site [chemical binding]; other site 526227001062 Walker B motif; other site 526227001063 arginine finger; other site 526227001064 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227001065 Walker A motif; other site 526227001066 ATP binding site [chemical binding]; other site 526227001067 Walker B motif; other site 526227001068 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 526227001069 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 526227001070 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 526227001071 putative homodimer interface [polypeptide binding]; other site 526227001072 putative homotetramer interface [polypeptide binding]; other site 526227001073 putative allosteric switch controlling residues; other site 526227001074 putative metal binding site [ion binding]; other site 526227001075 putative homodimer-homodimer interface [polypeptide binding]; other site 526227001076 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14963 526227001077 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227001078 Walker A motif; other site 526227001079 ATP binding site [chemical binding]; other site 526227001080 Walker B motif; other site 526227001081 arginine finger; other site 526227001082 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 526227001083 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 526227001084 dimer interface [polypeptide binding]; other site 526227001085 FMN binding site [chemical binding]; other site 526227001086 NADPH bind site [chemical binding]; other site 526227001087 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 526227001088 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 526227001089 peptide chain release factor 2; Validated; Region: prfB; PRK00578 526227001090 RF-1 domain; Region: RF-1; cl02875 526227001091 RF-1 domain; Region: RF-1; cl02875 526227001092 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 526227001093 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 526227001094 hinge; other site 526227001095 active site 526227001096 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227001097 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227001098 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 526227001099 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 526227001100 N-acetyl-D-glucosamine binding site [chemical binding]; other site 526227001101 catalytic residue [active] 526227001102 Rhomboid family; Region: Rhomboid; cl11446 526227001103 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 526227001104 peptide chain release factor 1; Provisional; Region: PRK04011 526227001105 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 526227001106 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 526227001107 putative dimer interface [polypeptide binding]; other site 526227001108 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 526227001109 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 526227001110 active site 526227001111 Rhomboid family; Region: Rhomboid; cl11446 526227001112 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 526227001113 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 526227001114 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 526227001115 Phosphate-starvation-inducible E; Region: PsiE; cl01264 526227001116 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 526227001117 putative dimer interface [polypeptide binding]; other site 526227001118 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 526227001119 catalytic residues [active] 526227001120 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 526227001121 dinuclear metal binding motif [ion binding]; other site 526227001122 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 526227001123 catalytic residues [active] 526227001124 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 526227001125 dimer interface [polypeptide binding]; other site 526227001126 catalytic triad [active] 526227001127 Ferritin-like domain; Region: Ferritin; pfam00210 526227001128 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 526227001129 dinuclear metal binding motif [ion binding]; other site 526227001130 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 526227001131 Clp amino terminal domain; Region: Clp_N; pfam02861 526227001132 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227001133 Walker A motif; other site 526227001134 ATP binding site [chemical binding]; other site 526227001135 Walker B motif; other site 526227001136 arginine finger; other site 526227001137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227001138 Walker A motif; other site 526227001139 ATP binding site [chemical binding]; other site 526227001140 Walker B motif; other site 526227001141 arginine finger; other site 526227001142 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 526227001143 amidase; Provisional; Region: PRK06828 526227001144 Amidase; Region: Amidase; cl11426 526227001145 DNA primase domain-containing protein; Region: PHA02415 526227001146 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 526227001147 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 526227001148 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 526227001149 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 526227001150 active site 526227001151 catalytic tetrad [active] 526227001152 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 526227001153 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 526227001154 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 526227001155 chaperone protein DnaJ; Provisional; Region: PRK14299 526227001156 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 526227001157 HSP70 interaction site [polypeptide binding]; other site 526227001158 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 526227001159 substrate binding site [polypeptide binding]; other site 526227001160 dimer interface [polypeptide binding]; other site 526227001161 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 526227001162 dimer interface [polypeptide binding]; other site 526227001163 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 526227001164 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 526227001165 StbA protein; Region: StbA; pfam06406 526227001166 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 526227001167 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227001168 Walker A motif; other site 526227001169 ATP binding site [chemical binding]; other site 526227001170 Walker B motif; other site 526227001171 arginine finger; other site 526227001172 Peptidase family M41; Region: Peptidase_M41; pfam01434 526227001173 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 526227001174 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 526227001175 dimerization interface [polypeptide binding]; other site 526227001176 DPS ferroxidase diiron center [ion binding]; other site 526227001177 ion pore; other site 526227001178 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 526227001179 IHF dimer interface [polypeptide binding]; other site 526227001180 IHF - DNA interface [nucleotide binding]; other site 526227001181 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 526227001182 putative acyl-acceptor binding pocket; other site 526227001183 Uncharacterized conserved protein [Function unknown]; Region: COG1543 526227001184 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 526227001185 AAK_NAGK-UC: N-Acetyl-L-glutamate kinase - uncharacterized (NAGK-UC). This domain is similar to Escherichia coli and Pseudomonas aeruginosa NAGKs which catalyze the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the...; Region: AAK_NAGK-UC; cd04251 526227001186 putative nucleotide binding site [chemical binding]; other site 526227001187 putative N-acetyl-L-glutamate binding site [chemical binding]; other site 526227001188 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 526227001189 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227001190 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 526227001191 Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144 526227001192 ATP-grasp domain; Region: ATP-grasp_4; cl03087 526227001193 lysine biosynthesis protein LysW; Region: lysW; TIGR01206 526227001194 NAD-dependent deacetylase; Provisional; Region: PRK00481 526227001195 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 526227001196 substrate binding site [chemical binding]; other site 526227001197 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 526227001198 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 526227001199 substrate binding site [chemical binding]; other site 526227001200 ligand binding site [chemical binding]; other site 526227001201 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 526227001202 YcfA-like protein; Region: YcfA; cl00752 526227001203 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 526227001204 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 526227001205 active site 526227001206 catalytic residues [active] 526227001207 metal binding site [ion binding]; metal-binding site 526227001208 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 526227001209 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 526227001210 catalytic residue [active] 526227001211 putative FPP diphosphate binding site; other site 526227001212 putative FPP binding hydrophobic cleft; other site 526227001213 dimer interface [polypeptide binding]; other site 526227001214 putative IPP diphosphate binding site; other site 526227001215 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 526227001216 RNA/DNA hybrid binding site [nucleotide binding]; other site 526227001217 active site 526227001218 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 526227001219 Immunoglobulin domain; Region: Ig; cl11960 526227001220 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 526227001221 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 526227001222 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 526227001223 DctM-like transporters; Region: DctM; pfam06808 526227001224 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 526227001225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227001226 putative substrate translocation pore; other site 526227001227 putative transposase OrfB; Reviewed; Region: PHA02517 526227001228 Integrase core domain; Region: rve; cl01316 526227001229 Integrase core domain; Region: rve_3; cl15866 526227001230 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 526227001231 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 526227001232 Fibronectin type III-like domain; Region: Fn3-like; cl15273 526227001233 Transcriptional regulators [Transcription]; Region: PurR; COG1609 526227001234 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 526227001235 DNA binding site [nucleotide binding] 526227001236 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 526227001237 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 526227001238 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 526227001239 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 526227001240 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227001241 DinB superfamily; Region: DinB_2; pfam12867 526227001242 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 526227001243 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 526227001244 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227001245 NAD(P) binding site [chemical binding]; other site 526227001246 active site 526227001247 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 526227001248 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 526227001249 NADP binding site [chemical binding]; other site 526227001250 dimer interface [polypeptide binding]; other site 526227001251 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526227001252 Mitomycin C resistance protein (MRD); Region: MRD; cd07235 526227001253 dimer interface [polypeptide binding]; other site 526227001254 ligand binding site [chemical binding]; other site 526227001255 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 526227001256 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 526227001257 intrachain domain interface; other site 526227001258 interchain domain interface [polypeptide binding]; other site 526227001259 heme bL binding site [chemical binding]; other site 526227001260 heme bH binding site [chemical binding]; other site 526227001261 Qo binding site; other site 526227001262 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 526227001263 intrachain domain interface; other site 526227001264 Qo binding site; other site 526227001265 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 526227001266 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 526227001267 iron-sulfur cluster [ion binding]; other site 526227001268 [2Fe-2S] cluster binding site [ion binding]; other site 526227001269 Cytochrome c; Region: Cytochrom_C; cl11414 526227001270 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 526227001271 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 526227001272 Metal-binding active site; metal-binding site 526227001273 fructoselysine 3-epimerase; Provisional; Region: PRK09856 526227001274 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 526227001275 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227001276 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 526227001277 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227001278 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 526227001279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227001280 putative PBP binding loops; other site 526227001281 ABC-ATPase subunit interface; other site 526227001282 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 526227001283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227001284 dimer interface [polypeptide binding]; other site 526227001285 putative PBP binding loops; other site 526227001286 ABC-ATPase subunit interface; other site 526227001287 hypothetical protein; Provisional; Region: PRK01184 526227001288 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 526227001289 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 526227001290 active site 526227001291 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 526227001292 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526227001293 active site 526227001294 motif I; other site 526227001295 motif II; other site 526227001296 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 526227001297 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 526227001298 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 526227001299 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526227001300 catalytic residue [active] 526227001301 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 526227001302 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 526227001303 catalytic residues [active] 526227001304 catalytic nucleophile [active] 526227001305 Recombinase; Region: Recombinase; pfam07508 526227001306 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 526227001307 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 526227001308 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 526227001309 non-specific DNA binding site [nucleotide binding]; other site 526227001310 salt bridge; other site 526227001311 sequence-specific DNA binding site [nucleotide binding]; other site 526227001312 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 526227001313 hypothetical protein; Provisional; Region: PRK14709 526227001314 D5 N terminal like; Region: D5_N; cl07360 526227001315 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 526227001316 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 526227001317 AAA-like domain; Region: AAA_10; pfam12846 526227001318 Domain of unknown function DUF87; Region: DUF87; pfam01935 526227001319 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227001320 ATP binding site [chemical binding]; other site 526227001321 Walker B motif; other site 526227001322 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 526227001323 catalytic site [active] 526227001324 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 526227001325 N-acetyl-D-glucosamine binding site [chemical binding]; other site 526227001326 catalytic residue [active] 526227001327 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227001328 Walker A motif; other site 526227001329 ATP binding site [chemical binding]; other site 526227001330 Walker B motif; other site 526227001331 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 526227001332 DNA binding residues [nucleotide binding] 526227001333 S-layer homology domain; Region: SLH; pfam00395 526227001334 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 526227001335 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 526227001336 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 526227001337 Helix-turn-helix domains; Region: HTH; cl00088 526227001338 Winged helix-turn helix; Region: HTH_29; pfam13551 526227001339 Helix-turn-helix domains; Region: HTH; cl00088 526227001340 Integrase core domain; Region: rve; cl01316 526227001341 Integrase core domain; Region: rve_3; cl15866 526227001342 RES domain; Region: RES; cl02411 526227001343 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 526227001344 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 526227001345 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 526227001346 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 526227001347 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227001348 Walker A/P-loop; other site 526227001349 ATP binding site [chemical binding]; other site 526227001350 Q-loop/lid; other site 526227001351 ABC transporter signature motif; other site 526227001352 Walker B; other site 526227001353 D-loop; other site 526227001354 H-loop/switch region; other site 526227001355 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 526227001356 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 526227001357 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 526227001358 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 526227001359 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 526227001360 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 526227001361 active site 526227001362 catalytic tetrad [active] 526227001363 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 526227001364 active site 526227001365 NTP binding site [chemical binding]; other site 526227001366 metal binding triad [ion binding]; metal-binding site 526227001367 KNTase C-terminal domain; Region: KNTase_C; pfam07827 526227001368 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 526227001369 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 526227001370 putative active site [active] 526227001371 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both synthetic; Region: POLBc; cl10023 526227001372 methyl coenzyme M reductase system, component A2; Region: met_CoM_red_A2; TIGR03269 526227001373 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227001374 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 526227001375 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 526227001376 Probable transposase; Region: OrfB_IS605; pfam01385 526227001377 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 526227001378 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 526227001379 Restriction endonuclease [Defense mechanisms]; Region: COG3587 526227001380 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227001381 Restriction endonuclease [Defense mechanisms]; Region: COG3587 526227001382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 526227001383 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 526227001384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 526227001385 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227001386 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 526227001387 active site 526227001388 DNA binding site [nucleotide binding] 526227001389 Int/Topo IB signature motif; other site 526227001390 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 526227001391 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227001392 Family description; Region: UvrD_C_2; cl15862 526227001393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 526227001394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 526227001395 NADH dehydrogenase subunit E; Provisional; Region: PRK12373 526227001396 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526227001397 putative DNA binding site [nucleotide binding]; other site 526227001398 putative Zn2+ binding site [ion binding]; other site 526227001399 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 526227001400 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227001401 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 526227001402 Family description; Region: UvrD_C_2; cl15862 526227001403 Staphylococcal nuclease homologues; Region: SNc; smart00318 526227001404 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 526227001405 Catalytic site; other site 526227001406 Excalibur calcium-binding domain; Region: Excalibur; cl05460 526227001407 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 526227001408 putative FMN binding site [chemical binding]; other site 526227001409 NADPH bind site [chemical binding]; other site 526227001410 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 526227001411 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 526227001412 Walker A/P-loop; other site 526227001413 ATP binding site [chemical binding]; other site 526227001414 Q-loop/lid; other site 526227001415 ABC transporter signature motif; other site 526227001416 Walker B; other site 526227001417 D-loop; other site 526227001418 H-loop/switch region; other site 526227001419 ABC-2 type transporter; Region: ABC2_membrane; cl11417 526227001420 Helix-turn-helix domains; Region: HTH; cl00088 526227001421 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 526227001422 transmembrane helices; other site 526227001423 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 526227001424 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 526227001425 putative active site [active] 526227001426 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 526227001427 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 526227001428 Walker A motif; other site 526227001429 ATP binding site [chemical binding]; other site 526227001430 Walker B motif; other site 526227001431 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 526227001432 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 526227001433 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 526227001434 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 526227001435 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 526227001436 Walker A motif; other site 526227001437 ATP binding site [chemical binding]; other site 526227001438 Walker B motif; other site 526227001439 HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase 526227001440 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526227001441 active site 526227001442 motif I; other site 526227001443 motif II; other site 526227001444 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 526227001445 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 526227001446 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 526227001447 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 526227001448 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 526227001449 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 526227001450 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 526227001451 active site 526227001452 Zn binding site [ion binding]; other site 526227001453 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 526227001454 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 526227001455 Flavin Reductases; Region: FlaRed; cl00801 526227001456 Predicted esterase [General function prediction only]; Region: COG0400 526227001457 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 526227001458 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 526227001459 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526227001460 Zn binding site [ion binding]; other site 526227001461 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 526227001462 Zn binding site [ion binding]; other site 526227001463 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 526227001464 catalytic residues [active] 526227001465 YceI-like domain; Region: YceI; cl01001 526227001466 Helix-turn-helix domains; Region: HTH; cl00088 526227001467 Helix-turn-helix domains; Region: HTH; cl00088 526227001468 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 526227001469 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 526227001470 ring oligomerisation interface [polypeptide binding]; other site 526227001471 ATP/Mg binding site [chemical binding]; other site 526227001472 stacking interactions; other site 526227001473 hinge regions; other site 526227001474 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 526227001475 oligomerisation interface [polypeptide binding]; other site 526227001476 mobile loop; other site 526227001477 roof hairpin; other site 526227001478 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 526227001479 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 526227001480 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 526227001481 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 526227001482 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 526227001483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227001484 CoA-ligase; Region: Ligase_CoA; cl02894 526227001485 CoA-ligase; Region: Ligase_CoA; cl02894 526227001486 ATP-grasp domain; Region: ATP-grasp_4; cl03087 526227001487 hypothetical protein; Provisional; Region: PRK13685 526227001488 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 526227001489 metal ion-dependent adhesion site (MIDAS); other site 526227001490 glucose-6-phosphate isomerase; Provisional; Region: PRK00973 526227001491 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 526227001492 active site 526227001493 dimer interface [polypeptide binding]; other site 526227001494 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 526227001495 dimer interface [polypeptide binding]; other site 526227001496 active site 526227001497 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 526227001498 active site 526227001499 NTP binding site [chemical binding]; other site 526227001500 metal binding triad [ion binding]; metal-binding site 526227001501 antibiotic binding site [chemical binding]; other site 526227001502 HEPN domain; Region: HEPN; cl00824 526227001503 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 526227001504 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 526227001505 active site 526227001506 substrate-binding site [chemical binding]; other site 526227001507 metal-binding site [ion binding] 526227001508 GTP binding site [chemical binding]; other site 526227001509 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 526227001510 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 526227001511 putative RNA polymerase sigma E protein; Provisional; Region: PRK13919 526227001512 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 526227001513 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 526227001514 DNA binding residues [nucleotide binding] 526227001515 putative anti-sigmaE protein; Provisional; Region: PRK13920 526227001516 Anti-sigma-K factor rskA; Region: RskA; pfam10099 526227001517 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 526227001518 UbiA prenyltransferase family; Region: UbiA; cl00337 526227001519 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 526227001520 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 526227001521 Cytochrome c; Region: Cytochrom_C; cl11414 526227001522 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 526227001523 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 526227001524 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 526227001525 D-pathway; other site 526227001526 Low-spin heme binding site [chemical binding]; other site 526227001527 Putative water exit pathway; other site 526227001528 Binuclear center (active site) [active] 526227001529 K-pathway; other site 526227001530 Putative proton exit pathway; other site 526227001531 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 526227001532 Subunit I/III interface [polypeptide binding]; other site 526227001533 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227001534 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 526227001535 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 526227001536 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 526227001537 active site 526227001538 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227001539 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 526227001540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227001541 S-adenosylmethionine binding site [chemical binding]; other site 526227001542 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 526227001543 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 526227001544 TM-ABC transporter signature motif; other site 526227001545 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 526227001546 TM-ABC transporter signature motif; other site 526227001547 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227001548 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 526227001549 Cytochrome P450; Region: p450; pfam00067 526227001550 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526227001551 metal binding site [ion binding]; metal-binding site 526227001552 active site 526227001553 I-site; other site 526227001554 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 526227001555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227001556 S-adenosylmethionine binding site [chemical binding]; other site 526227001557 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 526227001558 nudix motif; other site 526227001559 PSP1 C-terminal conserved region; Region: PSP1; cl00770 526227001560 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 526227001561 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227001562 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 526227001563 active site 526227001564 metal binding site [ion binding]; metal-binding site 526227001565 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227001566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227001567 dimer interface [polypeptide binding]; other site 526227001568 conserved gate region; other site 526227001569 putative PBP binding loops; other site 526227001570 ABC-ATPase subunit interface; other site 526227001571 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 526227001572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227001573 putative PBP binding loops; other site 526227001574 ABC-ATPase subunit interface; other site 526227001575 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 526227001576 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 526227001577 Walker A/P-loop; other site 526227001578 ATP binding site [chemical binding]; other site 526227001579 Q-loop/lid; other site 526227001580 ABC transporter signature motif; other site 526227001581 Walker B; other site 526227001582 D-loop; other site 526227001583 H-loop/switch region; other site 526227001584 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 526227001585 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 526227001586 conserved cys residue [active] 526227001587 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 526227001588 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 526227001589 GTP-binding protein YchF; Reviewed; Region: PRK09601 526227001590 YchF GTPase; Region: YchF; cd01900 526227001591 G1 box; other site 526227001592 GTP/Mg2+ binding site [chemical binding]; other site 526227001593 Switch I region; other site 526227001594 G2 box; other site 526227001595 Switch II region; other site 526227001596 G3 box; other site 526227001597 G4 box; other site 526227001598 G5 box; other site 526227001599 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 526227001600 Kelch motif; Region: Kelch_1; cl02701 526227001601 Kelch motif; Region: Kelch_1; cl02701 526227001602 Kelch motif; Region: Kelch_1; cl02701 526227001603 Kelch motif; Region: Kelch_1; cl02701 526227001604 Kelch motif; Region: Kelch_1; cl02701 526227001605 Helix-turn-helix domains; Region: HTH; cl00088 526227001606 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227001607 TPR motif; other site 526227001608 binding surface 526227001609 FtsH Extracellular; Region: FtsH_ext; pfam06480 526227001610 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 526227001611 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227001612 Walker A motif; other site 526227001613 ATP binding site [chemical binding]; other site 526227001614 Walker B motif; other site 526227001615 arginine finger; other site 526227001616 Peptidase family M41; Region: Peptidase_M41; pfam01434 526227001617 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 526227001618 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 526227001619 ATP-grasp domain; Region: ATP-grasp_4; cl03087 526227001620 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 526227001621 homodimer interface [polypeptide binding]; other site 526227001622 substrate-cofactor binding pocket; other site 526227001623 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227001624 catalytic residue [active] 526227001625 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 526227001626 putative active site [active] 526227001627 catalytic residue [active] 526227001628 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 526227001629 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 526227001630 5S rRNA interface [nucleotide binding]; other site 526227001631 CTC domain interface [polypeptide binding]; other site 526227001632 L16 interface [polypeptide binding]; other site 526227001633 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 526227001634 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 526227001635 active site 526227001636 homodimer interface [polypeptide binding]; other site 526227001637 catalytic site [active] 526227001638 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 526227001639 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 526227001640 Metal-binding active site; metal-binding site 526227001641 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 526227001642 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 526227001643 putative NAD(P) binding site [chemical binding]; other site 526227001644 alpha-glucosidase; Provisional; Region: PRK10137 526227001645 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 526227001646 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 526227001647 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227001648 Walker A/P-loop; other site 526227001649 ATP binding site [chemical binding]; other site 526227001650 Q-loop/lid; other site 526227001651 ABC transporter signature motif; other site 526227001652 Walker B; other site 526227001653 D-loop; other site 526227001654 H-loop/switch region; other site 526227001655 TOBE domain; Region: TOBE_2; cl01440 526227001656 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 526227001657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 526227001658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227001659 dimer interface [polypeptide binding]; other site 526227001660 conserved gate region; other site 526227001661 putative PBP binding loops; other site 526227001662 ABC-ATPase subunit interface; other site 526227001663 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 526227001664 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227001665 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227001666 Transcriptional regulators [Transcription]; Region: PurR; COG1609 526227001667 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 526227001668 DNA binding site [nucleotide binding] 526227001669 domain linker motif; other site 526227001670 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 526227001671 ligand binding site [chemical binding]; other site 526227001672 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 526227001673 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 526227001674 FAD binding site [chemical binding]; other site 526227001675 short chain dehydrogenase; Provisional; Region: PRK12828 526227001676 classical (c) SDRs; Region: SDR_c; cd05233 526227001677 NAD(P) binding site [chemical binding]; other site 526227001678 active site 526227001679 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 526227001680 Helix-turn-helix domains; Region: HTH; cl00088 526227001681 putative transposase OrfB; Reviewed; Region: PHA02517 526227001682 Integrase core domain; Region: rve; cl01316 526227001683 Integrase core domain; Region: rve_3; cl15866 526227001684 VanZ like family; Region: VanZ; cl01971 526227001685 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526227001686 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 526227001687 dimer interface [polypeptide binding]; other site 526227001688 substrate binding site [chemical binding]; other site 526227001689 metal binding site [ion binding]; metal-binding site 526227001690 Probable transposase; Region: OrfB_IS605; pfam01385 526227001691 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 526227001692 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 526227001693 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 526227001694 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 526227001695 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 526227001696 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 526227001697 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 526227001698 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 526227001699 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 526227001700 Helix-turn-helix domains; Region: HTH; cl00088 526227001701 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 526227001702 FeoA domain; Region: FeoA; cl00838 526227001703 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 526227001704 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 526227001705 intersubunit interface [polypeptide binding]; other site 526227001706 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 526227001707 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 526227001708 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 526227001709 ABC-ATPase subunit interface; other site 526227001710 dimer interface [polypeptide binding]; other site 526227001711 putative PBP binding regions; other site 526227001712 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 526227001713 ABC-ATPase subunit interface; other site 526227001714 dimer interface [polypeptide binding]; other site 526227001715 putative PBP binding regions; other site 526227001716 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 526227001717 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 526227001718 Fibronectin type III-like domain; Region: Fn3-like; cl15273 526227001719 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 526227001720 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 526227001721 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 526227001722 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 526227001723 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 526227001724 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 526227001725 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 526227001726 active site 526227001727 catalytic residues [active] 526227001728 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 526227001729 D-xylulose kinase; Region: XylB; TIGR01312 526227001730 N- and C-terminal domain interface [polypeptide binding]; other site 526227001731 active site 526227001732 catalytic site [active] 526227001733 metal binding site [ion binding]; metal-binding site 526227001734 xylulose binding site [chemical binding]; other site 526227001735 putative ATP binding site [chemical binding]; other site 526227001736 homodimer interface [polypeptide binding]; other site 526227001737 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 526227001738 CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578 526227001739 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 526227001740 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 526227001741 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 526227001742 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 526227001743 Rv0623-like transcription factor; Region: PSK_trans_fac; cl01834 526227001744 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 526227001745 putative active site [active] 526227001746 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 526227001747 CRISPR-associated protein (Cas_Cas02710); Region: Cas_Cas02710; pfam09670 526227001748 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09747 526227001749 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 526227001750 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 526227001751 CRISPR-associated protein (Cas_Cas02710); Region: Cas_Cas02710; pfam09670 526227001752 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 526227001753 putative transposase OrfB; Reviewed; Region: PHA02517 526227001754 Integrase core domain; Region: rve; cl01316 526227001755 Integrase core domain; Region: rve_3; cl15866 526227001756 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 526227001757 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 526227001758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227001759 homodimer interface [polypeptide binding]; other site 526227001760 catalytic residue [active] 526227001761 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 526227001762 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 526227001763 Walker A/P-loop; other site 526227001764 ATP binding site [chemical binding]; other site 526227001765 Q-loop/lid; other site 526227001766 ABC transporter signature motif; other site 526227001767 Walker B; other site 526227001768 D-loop; other site 526227001769 H-loop/switch region; other site 526227001770 Arginase family; Region: Arginase; cl00306 526227001771 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 526227001772 non-specific DNA binding site [nucleotide binding]; other site 526227001773 salt bridge; other site 526227001774 sequence-specific DNA binding site [nucleotide binding]; other site 526227001775 Cupin domain; Region: Cupin_2; cl09118 526227001776 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 526227001777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227001778 dimer interface [polypeptide binding]; other site 526227001779 conserved gate region; other site 526227001780 putative PBP binding loops; other site 526227001781 ABC-ATPase subunit interface; other site 526227001782 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 526227001783 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 526227001784 substrate binding pocket [chemical binding]; other site 526227001785 membrane-bound complex binding site; other site 526227001786 hinge residues; other site 526227001787 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 526227001788 active site 526227001789 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227001790 Predicted ATPase [General function prediction only]; Region: COG3903 526227001791 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227001792 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526227001793 DNA binding residues [nucleotide binding] 526227001794 dimerization interface [polypeptide binding]; other site 526227001795 Cupin domain; Region: Cupin_2; cl09118 526227001796 putative transposase OrfB; Reviewed; Region: PHA02517 526227001797 Integrase core domain; Region: rve; cl01316 526227001798 Integrase core domain; Region: rve_3; cl15866 526227001799 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 526227001800 DEAD-like helicases superfamily; Region: DEXDc; smart00487 526227001801 ATP binding site [chemical binding]; other site 526227001802 Mg++ binding site [ion binding]; other site 526227001803 motif III; other site 526227001804 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526227001805 nucleotide binding region [chemical binding]; other site 526227001806 ATP-binding site [chemical binding]; other site 526227001807 GUCT (NUC152) domain; Region: GUCT; pfam08152 526227001808 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 526227001809 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526227001810 Coenzyme A binding pocket [chemical binding]; other site 526227001811 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 526227001812 Coenzyme A binding pocket [chemical binding]; other site 526227001813 Protein of unknown function, DUF393; Region: DUF393; cl01136 526227001814 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 526227001815 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 526227001816 FeS/SAM binding site; other site 526227001817 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 526227001818 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 526227001819 dimer interface [polypeptide binding]; other site 526227001820 substrate binding site [chemical binding]; other site 526227001821 metal binding sites [ion binding]; metal-binding site 526227001822 putative transposase OrfB; Reviewed; Region: PHA02517 526227001823 Integrase core domain; Region: rve; cl01316 526227001824 Integrase core domain; Region: rve_3; cl15866 526227001825 alanyl-tRNA synthetase; Provisional; Region: alaS; PRK13902 526227001826 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 526227001827 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 526227001828 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 526227001829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 526227001830 NMT1-like family; Region: NMT1_2; cl15260 526227001831 Helix-turn-helix domains; Region: HTH; cl00088 526227001832 DNA-binding site [nucleotide binding]; DNA binding site 526227001833 FCD domain; Region: FCD; cl11656 526227001834 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 526227001835 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 526227001836 RNA binding surface [nucleotide binding]; other site 526227001837 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 526227001838 active site 526227001839 uracil binding [chemical binding]; other site 526227001840 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 526227001841 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526227001842 dimer interface [polypeptide binding]; other site 526227001843 phosphorylation site [posttranslational modification] 526227001844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227001845 ATP binding site [chemical binding]; other site 526227001846 Mg2+ binding site [ion binding]; other site 526227001847 G-X-G motif; other site 526227001848 DNA-binding response regulator CreB; Provisional; Region: PRK11083 526227001849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227001850 active site 526227001851 phosphorylation site [posttranslational modification] 526227001852 intermolecular recognition site; other site 526227001853 dimerization interface [polypeptide binding]; other site 526227001854 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526227001855 DNA binding site [nucleotide binding] 526227001856 Phospholipid methyltransferase; Region: PEMT; cl00763 526227001857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227001858 putative substrate translocation pore; other site 526227001859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227001860 Short C-terminal domain; Region: SHOCT; cl01373 526227001861 Short C-terminal domain; Region: SHOCT; cl01373 526227001862 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 526227001863 trimer interface [polypeptide binding]; other site 526227001864 active site 526227001865 Arginase family; Region: Arginase; cl00306 526227001866 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 526227001867 active site 526227001868 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 526227001869 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 526227001870 dimer interface [polypeptide binding]; other site 526227001871 motif 1; other site 526227001872 active site 526227001873 motif 2; other site 526227001874 motif 3; other site 526227001875 putative transposase OrfB; Reviewed; Region: PHA02517 526227001876 Integrase core domain; Region: rve; cl01316 526227001877 Integrase core domain; Region: rve_3; cl15866 526227001878 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 526227001879 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 526227001880 GTPase CgtA; Reviewed; Region: obgE; PRK12297 526227001881 GTP1/OBG; Region: GTP1_OBG; pfam01018 526227001882 Obg GTPase; Region: Obg; cd01898 526227001883 G1 box; other site 526227001884 GTP/Mg2+ binding site [chemical binding]; other site 526227001885 Switch I region; other site 526227001886 G2 box; other site 526227001887 G3 box; other site 526227001888 Switch II region; other site 526227001889 G4 box; other site 526227001890 G5 box; other site 526227001891 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 526227001892 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 526227001893 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 526227001894 active site 526227001895 (T/H)XGH motif; other site 526227001896 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 526227001897 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 526227001898 Zn2+ binding site [ion binding]; other site 526227001899 Mg2+ binding site [ion binding]; other site 526227001900 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 526227001901 Oligomerisation domain; Region: Oligomerisation; cl00519 526227001902 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 526227001903 metal binding site [ion binding]; metal-binding site 526227001904 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 526227001905 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 526227001906 Walker A motif; other site 526227001907 ATP binding site [chemical binding]; other site 526227001908 Walker B motif; other site 526227001909 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 526227001910 hypothetical protein; Provisional; Region: PRK08185 526227001911 intersubunit interface [polypeptide binding]; other site 526227001912 active site 526227001913 zinc binding site [ion binding]; other site 526227001914 Na+ binding site [ion binding]; other site 526227001915 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227001916 binding surface 526227001917 TPR motif; other site 526227001918 TPR repeat; Region: TPR_11; pfam13414 526227001919 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227001920 binding surface 526227001921 TPR motif; other site 526227001922 TPR repeat; Region: TPR_11; pfam13414 526227001923 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227001924 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227001925 binding surface 526227001926 TPR motif; other site 526227001927 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 526227001928 active site 526227001929 catalytic residues [active] 526227001930 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 526227001931 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 526227001932 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 526227001933 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 526227001934 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 526227001935 active site 526227001936 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 526227001937 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 526227001938 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227001939 oligomerization interface [polypeptide binding]; other site 526227001940 active site 526227001941 NAD+ binding site [chemical binding]; other site 526227001942 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 526227001943 Cation transport protein; Region: TrkH; cl10514 526227001944 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 526227001945 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 526227001946 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227001947 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 526227001948 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227001949 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 526227001950 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 526227001951 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 526227001952 EamA-like transporter family; Region: EamA; cl01037 526227001953 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 526227001954 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 526227001955 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 526227001956 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 526227001957 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 526227001958 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 526227001959 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 526227001960 Low molecular weight phosphatase family; Region: LMWPc; cd00115 526227001961 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 526227001962 active site 526227001963 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331 526227001964 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 526227001965 active site 526227001966 catalytic site [active] 526227001967 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 526227001968 putative transposase OrfB; Reviewed; Region: PHA02517 526227001969 Integrase core domain; Region: rve; cl01316 526227001970 Integrase core domain; Region: rve_3; cl15866 526227001971 D-lactate dehydrogenase [cytochrome]; Region: PLN02805 526227001972 FAD binding domain; Region: FAD_binding_4; pfam01565 526227001973 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 526227001974 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 526227001975 active site 526227001976 catalytic tetrad [active] 526227001977 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 526227001978 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 526227001979 Helix-turn-helix domains; Region: HTH; cl00088 526227001980 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 526227001981 NADH(P)-binding; Region: NAD_binding_10; pfam13460 526227001982 NAD binding site [chemical binding]; other site 526227001983 substrate binding site [chemical binding]; other site 526227001984 putative active site [active] 526227001985 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 526227001986 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526227001987 active site 526227001988 metal binding site [ion binding]; metal-binding site 526227001989 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 526227001990 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 526227001991 active site 526227001992 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 526227001993 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 526227001994 Walker A/P-loop; other site 526227001995 ATP binding site [chemical binding]; other site 526227001996 Q-loop/lid; other site 526227001997 ABC transporter signature motif; other site 526227001998 Walker B; other site 526227001999 D-loop; other site 526227002000 H-loop/switch region; other site 526227002001 ABC-2 type transporter; Region: ABC2_membrane; cl11417 526227002002 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 526227002003 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 526227002004 Walker A/P-loop; other site 526227002005 ATP binding site [chemical binding]; other site 526227002006 Q-loop/lid; other site 526227002007 ABC transporter signature motif; other site 526227002008 Walker B; other site 526227002009 D-loop; other site 526227002010 H-loop/switch region; other site 526227002011 Predicted transcriptional regulators [Transcription]; Region: COG1725 526227002012 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 526227002013 DNA-binding site [nucleotide binding]; DNA binding site 526227002014 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 526227002015 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227002016 Walker A/P-loop; other site 526227002017 ATP binding site [chemical binding]; other site 526227002018 Q-loop/lid; other site 526227002019 ABC transporter signature motif; other site 526227002020 Walker B; other site 526227002021 D-loop; other site 526227002022 H-loop/switch region; other site 526227002023 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227002024 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227002025 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 526227002026 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 526227002027 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 526227002028 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 526227002029 Walker A/P-loop; other site 526227002030 ATP binding site [chemical binding]; other site 526227002031 Q-loop/lid; other site 526227002032 ABC transporter signature motif; other site 526227002033 Walker B; other site 526227002034 D-loop; other site 526227002035 H-loop/switch region; other site 526227002036 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 526227002037 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 526227002038 FtsX-like permease family; Region: FtsX; cl15850 526227002039 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 526227002040 active site 526227002041 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 526227002042 catalytic tetrad [active] 526227002043 AAA domain; Region: AAA_32; pfam13654 526227002044 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 526227002045 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 526227002046 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 526227002047 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 526227002048 ligand binding site; other site 526227002049 oligomer interface; other site 526227002050 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 526227002051 dimer interface [polypeptide binding]; other site 526227002052 N-terminal domain interface [polypeptide binding]; other site 526227002053 sulfate 1 binding site; other site 526227002054 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 526227002055 NADPH bind site [chemical binding]; other site 526227002056 putative FMN binding site [chemical binding]; other site 526227002057 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227002058 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 526227002059 putative active site pocket [active] 526227002060 dimerization interface [polypeptide binding]; other site 526227002061 putative catalytic residue [active] 526227002062 glycogen synthase; Provisional; Region: glgA; PRK00654 526227002063 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 526227002064 ADP-binding pocket [chemical binding]; other site 526227002065 homodimer interface [polypeptide binding]; other site 526227002066 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227002067 binding surface 526227002068 Tetratricopeptide repeat; Region: TPR_16; pfam13432 526227002069 TPR motif; other site 526227002070 Protein of unknown function (DUF421); Region: DUF421; cl00990 526227002071 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 526227002072 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 526227002073 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 526227002074 NMT1/THI5 like; Region: NMT1; pfam09084 526227002075 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 526227002076 substrate binding pocket [chemical binding]; other site 526227002077 membrane-bound complex binding site; other site 526227002078 hinge residues; other site 526227002079 Uncharacterized conserved protein [Function unknown]; Region: COG4715 526227002080 SWIM zinc finger; Region: SWIM; cl15408 526227002081 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 526227002082 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 526227002083 Walker A/P-loop; other site 526227002084 ATP binding site [chemical binding]; other site 526227002085 Q-loop/lid; other site 526227002086 ABC transporter signature motif; other site 526227002087 Walker B; other site 526227002088 D-loop; other site 526227002089 H-loop/switch region; other site 526227002090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227002091 dimer interface [polypeptide binding]; other site 526227002092 conserved gate region; other site 526227002093 putative PBP binding loops; other site 526227002094 ABC-ATPase subunit interface; other site 526227002095 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526227002096 dimer interface [polypeptide binding]; other site 526227002097 phosphorylation site [posttranslational modification] 526227002098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227002099 Mg2+ binding site [ion binding]; other site 526227002100 G-X-G motif; other site 526227002101 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526227002102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227002103 active site 526227002104 phosphorylation site [posttranslational modification] 526227002105 intermolecular recognition site; other site 526227002106 dimerization interface [polypeptide binding]; other site 526227002107 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526227002108 DNA binding site [nucleotide binding] 526227002109 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 526227002110 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 526227002111 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 526227002112 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 526227002113 RPB12 interaction site [polypeptide binding]; other site 526227002114 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 526227002115 RPB10 interaction site [polypeptide binding]; other site 526227002116 RPB1 interaction site [polypeptide binding]; other site 526227002117 RPB11 interaction site [polypeptide binding]; other site 526227002118 RPB3 interaction site [polypeptide binding]; other site 526227002119 RPB12 interaction site [polypeptide binding]; other site 526227002120 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 526227002121 pyruvate carboxylase subunit B; Validated; Region: PRK09282 526227002122 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 526227002123 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 526227002124 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 526227002125 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 526227002126 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 526227002127 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 526227002128 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 526227002129 G-loop; other site 526227002130 DNA binding site [nucleotide binding] 526227002131 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 526227002132 intersubunit interface [polypeptide binding]; other site 526227002133 active site 526227002134 Zn2+ binding site [ion binding]; other site 526227002135 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526227002136 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 526227002137 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 526227002138 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 526227002139 dimer interface [polypeptide binding]; other site 526227002140 ssDNA binding site [nucleotide binding]; other site 526227002141 tetramer (dimer of dimers) interface [polypeptide binding]; other site 526227002142 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 526227002143 dimer interface [polypeptide binding]; other site 526227002144 ssDNA binding site [nucleotide binding]; other site 526227002145 tetramer (dimer of dimers) interface [polypeptide binding]; other site 526227002146 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 526227002147 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 526227002148 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 526227002149 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 526227002150 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 526227002151 lipoyl synthase; Provisional; Region: PRK05481 526227002152 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 526227002153 FeS/SAM binding site; other site 526227002154 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 526227002155 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 526227002156 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 526227002157 Ca binding site [ion binding]; other site 526227002158 active site 526227002159 catalytic site [active] 526227002160 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 526227002161 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227002162 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 526227002163 NAD(P) binding pocket [chemical binding]; other site 526227002164 FG-GAP repeat; Region: FG-GAP; cl15299 526227002165 Family description; Region: VCBS; pfam13517 526227002166 Family description; Region: VCBS; pfam13517 526227002167 Family description; Region: VCBS; pfam13517 526227002168 Family description; Region: VCBS; pfam13517 526227002169 Family description; Region: VCBS; pfam13517 526227002170 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 526227002171 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227002172 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227002173 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 526227002174 PhoU domain; Region: PhoU; pfam01895 526227002175 PhoU domain; Region: PhoU; pfam01895 526227002176 PAS domain S-box; Region: sensory_box; TIGR00229 526227002177 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 526227002178 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 526227002179 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526227002180 dimer interface [polypeptide binding]; other site 526227002181 phosphorylation site [posttranslational modification] 526227002182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227002183 ATP binding site [chemical binding]; other site 526227002184 Mg2+ binding site [ion binding]; other site 526227002185 G-X-G motif; other site 526227002186 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526227002187 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227002188 active site 526227002189 phosphorylation site [posttranslational modification] 526227002190 intermolecular recognition site; other site 526227002191 dimerization interface [polypeptide binding]; other site 526227002192 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526227002193 DNA binding site [nucleotide binding] 526227002194 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 526227002195 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 526227002196 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 526227002197 generic binding surface II; other site 526227002198 generic binding surface I; other site 526227002199 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 526227002200 metal binding site 2 [ion binding]; metal-binding site 526227002201 putative DNA binding helix; other site 526227002202 metal binding site 1 [ion binding]; metal-binding site 526227002203 dimer interface [polypeptide binding]; other site 526227002204 structural Zn2+ binding site [ion binding]; other site 526227002205 multifunctional aminopeptidase A; Provisional; Region: PRK00913 526227002206 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 526227002207 interface (dimer of trimers) [polypeptide binding]; other site 526227002208 Substrate-binding/catalytic site; other site 526227002209 Zn-binding sites [ion binding]; other site 526227002210 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 526227002211 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 526227002212 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 526227002213 Ligand Binding Site [chemical binding]; other site 526227002214 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 526227002215 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 526227002216 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 526227002217 competence damage-inducible protein A; Provisional; Region: PRK00549 526227002218 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 526227002219 putative MPT binding site; other site 526227002220 Competence-damaged protein; Region: CinA; cl00666 526227002221 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 526227002222 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 526227002223 recombinase A; Provisional; Region: recA; PRK09354 526227002224 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 526227002225 hexamer interface [polypeptide binding]; other site 526227002226 Walker A motif; other site 526227002227 ATP binding site [chemical binding]; other site 526227002228 Walker B motif; other site 526227002229 Plant ATP synthase F0; Region: YMF19; cl07975 526227002230 hypothetical protein; Provisional; Region: PRK12705 526227002231 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 526227002232 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 526227002233 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 526227002234 P-loop; other site 526227002235 Magnesium ion binding site [ion binding]; other site 526227002236 rod shape-determining protein MreB; Provisional; Region: PRK13930 526227002237 Cell division protein FtsA; Region: FtsA; cl11496 526227002238 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 526227002239 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 526227002240 putative trimer interface [polypeptide binding]; other site 526227002241 putative CoA binding site [chemical binding]; other site 526227002242 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 526227002243 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 526227002244 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 526227002245 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227002246 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 526227002247 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 526227002248 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 526227002249 active site 526227002250 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 526227002251 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 526227002252 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227002253 Walker A/P-loop; other site 526227002254 ATP binding site [chemical binding]; other site 526227002255 Q-loop/lid; other site 526227002256 ABC transporter signature motif; other site 526227002257 Walker B; other site 526227002258 D-loop; other site 526227002259 H-loop/switch region; other site 526227002260 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526227002261 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526227002262 dimerization interface [polypeptide binding]; other site 526227002263 DNA binding residues [nucleotide binding] 526227002264 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 526227002265 catalytic residues [active] 526227002266 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 526227002267 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526227002268 MULE transposase domain; Region: MULE; pfam10551 526227002269 CCC1-related family of proteins; Region: CCC1_like; cl00278 526227002270 putative transposase OrfB; Reviewed; Region: PHA02517 526227002271 Integrase core domain; Region: rve; cl01316 526227002272 Integrase core domain; Region: rve_3; cl15866 526227002273 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 526227002274 Esterase/lipase [General function prediction only]; Region: COG1647 526227002275 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 526227002276 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 526227002277 aromatic acid decarboxylase; Validated; Region: PRK05920 526227002278 Flavoprotein; Region: Flavoprotein; cl08021 526227002279 Bacitracin resistance protein BacA; Region: BacA; cl00858 526227002280 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 526227002281 substrate binding site; other site 526227002282 dimer interface; other site 526227002283 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14612 526227002284 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 526227002285 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227002286 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 526227002287 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 526227002288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 526227002289 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 526227002290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 526227002291 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 526227002292 putative active site [active] 526227002293 putative transposase OrfB; Reviewed; Region: PHA02517 526227002294 Integrase core domain; Region: rve; cl01316 526227002295 Integrase core domain; Region: rve_3; cl15866 526227002296 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526227002297 metal binding site [ion binding]; metal-binding site 526227002298 active site 526227002299 I-site; other site 526227002300 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 526227002301 putative RNA polymerase sigma E protein; Provisional; Region: PRK13919 526227002302 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 526227002303 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 526227002304 DNA binding residues [nucleotide binding] 526227002305 Putative zinc-finger; Region: zf-HC2; cl15806 526227002306 putative anti-sigmaE protein; Provisional; Region: PRK13920 526227002307 Anti-sigma-K factor rskA; Region: RskA; pfam10099 526227002308 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 526227002309 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 526227002310 metal binding site [ion binding]; metal-binding site 526227002311 dimer interface [polypeptide binding]; other site 526227002312 putative transposase OrfB; Reviewed; Region: PHA02517 526227002313 Integrase core domain; Region: rve; cl01316 526227002314 Integrase core domain; Region: rve_3; cl15866 526227002315 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 526227002316 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 526227002317 oligomeric interface; other site 526227002318 putative active site [active] 526227002319 homodimer interface [polypeptide binding]; other site 526227002320 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 526227002321 putative deacylase active site [active] 526227002322 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 526227002323 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 526227002324 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 526227002325 NAD(P) binding site [chemical binding]; other site 526227002326 calcium/proton exchanger (cax); Region: cax; TIGR00378 526227002327 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 526227002328 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 526227002329 CoA-transferase family III; Region: CoA_transf_3; pfam02515 526227002330 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227002331 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227002332 NMT1-like family; Region: NMT1_2; cl15260 526227002333 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 526227002334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 526227002335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 526227002336 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 526227002337 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 526227002338 Walker A/P-loop; other site 526227002339 ATP binding site [chemical binding]; other site 526227002340 Q-loop/lid; other site 526227002341 ABC transporter signature motif; other site 526227002342 Walker B; other site 526227002343 D-loop; other site 526227002344 H-loop/switch region; other site 526227002345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227002346 ABC-ATPase subunit interface; other site 526227002347 ATP-grasp domain; Region: ATP-grasp_4; cl03087 526227002348 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 526227002349 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 526227002350 Walker A/P-loop; other site 526227002351 ATP binding site [chemical binding]; other site 526227002352 Q-loop/lid; other site 526227002353 ABC transporter signature motif; other site 526227002354 Walker B; other site 526227002355 D-loop; other site 526227002356 H-loop/switch region; other site 526227002357 ABC-2 type transporter; Region: ABC2_membrane; cl11417 526227002358 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 526227002359 trimer interface [polypeptide binding]; other site 526227002360 dimer interface [polypeptide binding]; other site 526227002361 putative active site [active] 526227002362 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 526227002363 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 526227002364 active site 526227002365 metal binding site [ion binding]; metal-binding site 526227002366 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 526227002367 putative active site [active] 526227002368 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 526227002369 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 526227002370 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 526227002371 putative catalytic residue [active] 526227002372 Copper resistance protein D; Region: CopD; cl00563 526227002373 Bacterial Ig-like domain; Region: Big_5; cl01012 526227002374 Protein of unknown function (DUF461); Region: DUF461; cl01071 526227002375 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 526227002376 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 526227002377 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 526227002378 trimer interface [polypeptide binding]; other site 526227002379 putative metal binding site [ion binding]; other site 526227002380 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 526227002381 active site 526227002382 Ap6A binding site [chemical binding]; other site 526227002383 nudix motif; other site 526227002384 metal binding site [ion binding]; metal-binding site 526227002385 Uncharacterized conserved protein [Function unknown]; Region: COG3342 526227002386 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 526227002387 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 526227002388 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 526227002389 Thiamine pyrophosphokinase; Region: TPK; cd07995 526227002390 active site 526227002391 thiamine binding site [chemical binding]; other site 526227002392 dimerization interface [polypeptide binding]; other site 526227002393 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227002394 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 526227002395 Walker A/P-loop; other site 526227002396 ATP binding site [chemical binding]; other site 526227002397 Q-loop/lid; other site 526227002398 ABC transporter signature motif; other site 526227002399 Walker B; other site 526227002400 D-loop; other site 526227002401 H-loop/switch region; other site 526227002402 Response regulator receiver domain; Region: Response_reg; pfam00072 526227002403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227002404 active site 526227002405 phosphorylation site [posttranslational modification] 526227002406 intermolecular recognition site; other site 526227002407 dimerization interface [polypeptide binding]; other site 526227002408 GAF domain; Region: GAF_2; pfam13185 526227002409 GAF domain; Region: GAF; cl15785 526227002410 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 526227002411 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 526227002412 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 526227002413 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526227002414 dimer interface [polypeptide binding]; other site 526227002415 phosphorylation site [posttranslational modification] 526227002416 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227002417 ATP binding site [chemical binding]; other site 526227002418 Mg2+ binding site [ion binding]; other site 526227002419 G-X-G motif; other site 526227002420 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 526227002421 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 526227002422 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 526227002423 Walker A/P-loop; other site 526227002424 ATP binding site [chemical binding]; other site 526227002425 Q-loop/lid; other site 526227002426 ABC transporter signature motif; other site 526227002427 Walker B; other site 526227002428 D-loop; other site 526227002429 H-loop/switch region; other site 526227002430 CcmB protein; Region: CcmB; cl01016 526227002431 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 526227002432 CcmE; Region: CcmE; cl00994 526227002433 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 526227002434 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 526227002435 catalytic residues [active] 526227002436 Cytochrome C biogenesis protein; Region: CcmH; cl01179 526227002437 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227002438 binding surface 526227002439 Tetratricopeptide repeat; Region: TPR_16; pfam13432 526227002440 TPR motif; other site 526227002441 Cytochrome c; Region: Cytochrom_C; cl11414 526227002442 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 526227002443 iron-sulfur cluster [ion binding]; other site 526227002444 [2Fe-2S] cluster binding site [ion binding]; other site 526227002445 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 526227002446 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 526227002447 active site 526227002448 HIGH motif; other site 526227002449 dimer interface [polypeptide binding]; other site 526227002450 KMSKS motif; other site 526227002451 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 526227002452 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 526227002453 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 526227002454 homoserine kinase; Provisional; Region: PRK01212 526227002455 putative carbohydrate kinase; Provisional; Region: PRK10565 526227002456 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 526227002457 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 526227002458 putative substrate binding site [chemical binding]; other site 526227002459 putative ATP binding site [chemical binding]; other site 526227002460 NAD-dependent deacetylase; Provisional; Region: PRK00481 526227002461 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 526227002462 NAD+ binding site [chemical binding]; other site 526227002463 substrate binding site [chemical binding]; other site 526227002464 Zn binding site [ion binding]; other site 526227002465 GTP-binding protein Der; Reviewed; Region: PRK00093 526227002466 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 526227002467 G1 box; other site 526227002468 GTP/Mg2+ binding site [chemical binding]; other site 526227002469 Switch I region; other site 526227002470 G2 box; other site 526227002471 Switch II region; other site 526227002472 G3 box; other site 526227002473 G4 box; other site 526227002474 G5 box; other site 526227002475 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 526227002476 G1 box; other site 526227002477 GTP/Mg2+ binding site [chemical binding]; other site 526227002478 Switch I region; other site 526227002479 G2 box; other site 526227002480 G3 box; other site 526227002481 Switch II region; other site 526227002482 G4 box; other site 526227002483 G5 box; other site 526227002484 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 526227002485 DinB superfamily; Region: DinB_2; pfam12867 526227002486 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 526227002487 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227002488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227002489 dimer interface [polypeptide binding]; other site 526227002490 conserved gate region; other site 526227002491 putative PBP binding loops; other site 526227002492 ABC-ATPase subunit interface; other site 526227002493 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 526227002494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227002495 ABC-ATPase subunit interface; other site 526227002496 putative PBP binding loops; other site 526227002497 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 526227002498 putative acyl-acceptor binding pocket; other site 526227002499 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 526227002500 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 526227002501 dimer interface [polypeptide binding]; other site 526227002502 active site 526227002503 glycine-pyridoxal phosphate binding site [chemical binding]; other site 526227002504 folate binding site [chemical binding]; other site 526227002505 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227002506 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227002507 FOG: CBS domain [General function prediction only]; Region: COG0517 526227002508 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 526227002509 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 526227002510 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 526227002511 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 526227002512 Predicted ATP-utilizing enzyme (ATP-grasp superfamily) [General function prediction only]; Region: COG1821 526227002513 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 526227002514 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 526227002515 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: APH; cd05150 526227002516 Phosphotransferase enzyme family; Region: APH; pfam01636 526227002517 active site 526227002518 ATP binding site [chemical binding]; other site 526227002519 antibiotic binding site [chemical binding]; other site 526227002520 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 526227002521 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 526227002522 active site 526227002523 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 526227002524 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 526227002525 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 526227002526 putative NAD(P) binding site [chemical binding]; other site 526227002527 putative active site [active] 526227002528 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 526227002529 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 526227002530 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 526227002531 DNA-binding site [nucleotide binding]; DNA binding site 526227002532 RNA-binding motif; other site 526227002533 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 526227002534 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 526227002535 HSP70 interaction site [polypeptide binding]; other site 526227002536 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 526227002537 Zn binding sites [ion binding]; other site 526227002538 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 526227002539 dimer interface [polypeptide binding]; other site 526227002540 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 526227002541 trehalose synthase; Region: treS_nterm; TIGR02456 526227002542 active site 526227002543 catalytic site [active] 526227002544 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 526227002545 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 526227002546 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 526227002547 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 526227002548 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 526227002549 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526227002550 catalytic residue [active] 526227002551 recombination factor protein RarA; Reviewed; Region: PRK13342 526227002552 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227002553 Walker A motif; other site 526227002554 ATP binding site [chemical binding]; other site 526227002555 Walker B motif; other site 526227002556 arginine finger; other site 526227002557 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 526227002558 PaaX-like protein; Region: PaaX; pfam07848 526227002559 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 526227002560 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 526227002561 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 526227002562 MatE; Region: MatE; cl10513 526227002563 MatE; Region: MatE; cl10513 526227002564 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 526227002565 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 526227002566 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 526227002567 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 526227002568 active site 526227002569 dimer interface [polypeptide binding]; other site 526227002570 motif 1; other site 526227002571 motif 2; other site 526227002572 motif 3; other site 526227002573 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 526227002574 anticodon binding site; other site 526227002575 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 526227002576 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 526227002577 ATP-binding site [chemical binding]; other site 526227002578 Gluconate-6-phosphate binding site [chemical binding]; other site 526227002579 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 526227002580 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 526227002581 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 526227002582 Active site serine [active] 526227002583 Putative cyclase; Region: Cyclase; cl00814 526227002584 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 526227002585 active site 526227002586 Fe-S cluster binding site [ion binding]; other site 526227002587 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227002588 hypothetical protein; Provisional; Region: PRK13795 526227002589 4Fe-4S binding domain; Region: Fer4; cl02805 526227002590 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 526227002591 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 526227002592 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 526227002593 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 526227002594 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 526227002595 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 526227002596 DNA binding site [nucleotide binding] 526227002597 active site 526227002598 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 526227002599 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 526227002600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227002601 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 526227002602 KduI/IolB family; Region: KduI; cl01508 526227002603 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 526227002604 Helix-turn-helix domains; Region: HTH; cl00088 526227002605 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 526227002606 phosphoenolpyruvate synthase; Validated; Region: PRK06464 526227002607 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 526227002608 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 526227002609 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 526227002610 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 526227002611 phytoene desaturase; Region: crtI_fam; TIGR02734 526227002612 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227002613 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 526227002614 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 526227002615 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 526227002616 Walker A/P-loop; other site 526227002617 ATP binding site [chemical binding]; other site 526227002618 Q-loop/lid; other site 526227002619 ABC transporter signature motif; other site 526227002620 Walker B; other site 526227002621 D-loop; other site 526227002622 H-loop/switch region; other site 526227002623 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 526227002624 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 526227002625 trimerization site [polypeptide binding]; other site 526227002626 active site 526227002627 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 526227002628 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 526227002629 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526227002630 catalytic residue [active] 526227002631 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 526227002632 [2Fe-2S] cluster binding site [ion binding]; other site 526227002633 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 526227002634 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 526227002635 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 526227002636 FeS assembly protein SufB; Region: sufB; TIGR01980 526227002637 FeS assembly ATPase SufC; Region: sufC; TIGR01978 526227002638 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 526227002639 Walker A/P-loop; other site 526227002640 ATP binding site [chemical binding]; other site 526227002641 Q-loop/lid; other site 526227002642 ABC transporter signature motif; other site 526227002643 Walker B; other site 526227002644 D-loop; other site 526227002645 H-loop/switch region; other site 526227002646 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 526227002647 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 526227002648 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 526227002649 tetramer interface [polypeptide binding]; other site 526227002650 active site 526227002651 Mg2+/Mn2+ binding site [ion binding]; other site 526227002652 Transcriptional regulators [Transcription]; Region: GntR; COG1802 526227002653 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 526227002654 DNA-binding site [nucleotide binding]; DNA binding site 526227002655 FCD domain; Region: FCD; cl11656 526227002656 SAF domain; Region: SAF; cl00555 526227002657 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 526227002658 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 526227002659 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 526227002660 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227002661 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 526227002662 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 526227002663 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227002664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227002665 dimer interface [polypeptide binding]; other site 526227002666 putative PBP binding loops; other site 526227002667 ABC-ATPase subunit interface; other site 526227002668 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 526227002669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227002670 dimer interface [polypeptide binding]; other site 526227002671 conserved gate region; other site 526227002672 putative PBP binding loops; other site 526227002673 ABC-ATPase subunit interface; other site 526227002674 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 526227002675 trimer interface [polypeptide binding]; other site 526227002676 hexamer (dimer of trimers) interface [polypeptide binding]; other site 526227002677 substrate binding site [chemical binding]; other site 526227002678 Mn binding site [ion binding]; other site 526227002679 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 526227002680 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 526227002681 substrate binding site [chemical binding]; other site 526227002682 ATP binding site [chemical binding]; other site 526227002683 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 526227002684 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 526227002685 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 526227002686 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 526227002687 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 526227002688 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 526227002689 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526227002690 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 526227002691 Protein of unknown function (DUF419); Region: DUF419; cl15265 526227002692 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 526227002693 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227002694 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 526227002695 glycerol kinase; Provisional; Region: glpK; PRK00047 526227002696 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 526227002697 N- and C-terminal domain interface [polypeptide binding]; other site 526227002698 active site 526227002699 MgATP binding site [chemical binding]; other site 526227002700 catalytic site [active] 526227002701 metal binding site [ion binding]; metal-binding site 526227002702 glycerol binding site [chemical binding]; other site 526227002703 homotetramer interface [polypeptide binding]; other site 526227002704 homodimer interface [polypeptide binding]; other site 526227002705 FBP binding site [chemical binding]; other site 526227002706 protein IIAGlc interface [polypeptide binding]; other site 526227002707 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 526227002708 heme-binding site [chemical binding]; other site 526227002709 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 526227002710 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 526227002711 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 526227002712 HIGH motif; other site 526227002713 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 526227002714 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 526227002715 active site 526227002716 KMSKS motif; other site 526227002717 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 526227002718 tRNA binding surface [nucleotide binding]; other site 526227002719 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227002720 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526227002721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227002722 active site 526227002723 phosphorylation site [posttranslational modification] 526227002724 intermolecular recognition site; other site 526227002725 dimerization interface [polypeptide binding]; other site 526227002726 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526227002727 DNA binding site [nucleotide binding] 526227002728 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 526227002729 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 526227002730 FMN binding site [chemical binding]; other site 526227002731 active site 526227002732 catalytic residues [active] 526227002733 substrate binding site [chemical binding]; other site 526227002734 LytB protein; Region: LYTB; cl00507 526227002735 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 526227002736 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 526227002737 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 526227002738 GTPase Era; Reviewed; Region: era; PRK00089 526227002739 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 526227002740 G1 box; other site 526227002741 GTP/Mg2+ binding site [chemical binding]; other site 526227002742 Switch I region; other site 526227002743 G2 box; other site 526227002744 Switch II region; other site 526227002745 G3 box; other site 526227002746 G4 box; other site 526227002747 G5 box; other site 526227002748 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 526227002749 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 526227002750 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 526227002751 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 526227002752 trimer interface [polypeptide binding]; other site 526227002753 active site 526227002754 substrate binding site [chemical binding]; other site 526227002755 CoA binding site [chemical binding]; other site 526227002756 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 526227002757 Predicted ATPase [General function prediction only]; Region: COG3899 526227002758 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227002759 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227002760 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227002761 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 526227002762 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 526227002763 Histidine kinase; Region: HisKA_3; pfam07730 526227002764 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 526227002765 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526227002766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227002767 active site 526227002768 phosphorylation site [posttranslational modification] 526227002769 intermolecular recognition site; other site 526227002770 dimerization interface [polypeptide binding]; other site 526227002771 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526227002772 DNA binding residues [nucleotide binding] 526227002773 dimerization interface [polypeptide binding]; other site 526227002774 amidophosphoribosyltransferase; Region: purF; TIGR01134 526227002775 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 526227002776 active site 526227002777 tetramer interface [polypeptide binding]; other site 526227002778 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 526227002779 active site 526227002780 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 526227002781 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 526227002782 dimerization interface [polypeptide binding]; other site 526227002783 ATP binding site [chemical binding]; other site 526227002784 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 526227002785 dimerization interface [polypeptide binding]; other site 526227002786 ATP binding site [chemical binding]; other site 526227002787 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 526227002788 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 526227002789 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 526227002790 putative active site [active] 526227002791 catalytic triad [active] 526227002792 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 526227002793 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 526227002794 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 526227002795 ATP binding site [chemical binding]; other site 526227002796 active site 526227002797 substrate binding site [chemical binding]; other site 526227002798 adenylosuccinate lyase; Provisional; Region: PRK07492 526227002799 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 526227002800 tetramer interface [polypeptide binding]; other site 526227002801 active site 526227002802 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 526227002803 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 526227002804 FtsX-like permease family; Region: FtsX; cl15850 526227002805 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 526227002806 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 526227002807 Walker A/P-loop; other site 526227002808 ATP binding site [chemical binding]; other site 526227002809 Q-loop/lid; other site 526227002810 ABC transporter signature motif; other site 526227002811 Walker B; other site 526227002812 D-loop; other site 526227002813 H-loop/switch region; other site 526227002814 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 526227002815 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 526227002816 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 526227002817 Outer membrane efflux protein; Region: OEP; pfam02321 526227002818 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 526227002819 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526227002820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227002821 active site 526227002822 phosphorylation site [posttranslational modification] 526227002823 intermolecular recognition site; other site 526227002824 dimerization interface [polypeptide binding]; other site 526227002825 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526227002826 DNA binding site [nucleotide binding] 526227002827 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 526227002828 dimerization interface [polypeptide binding]; other site 526227002829 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526227002830 dimer interface [polypeptide binding]; other site 526227002831 phosphorylation site [posttranslational modification] 526227002832 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 526227002833 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227002834 ATP binding site [chemical binding]; other site 526227002835 Mg2+ binding site [ion binding]; other site 526227002836 G-X-G motif; other site 526227002837 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 526227002838 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526227002839 motif II; other site 526227002840 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 526227002841 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 526227002842 nudix motif; other site 526227002843 putative transposase OrfB; Reviewed; Region: PHA02517 526227002844 Integrase core domain; Region: rve; cl01316 526227002845 Integrase core domain; Region: rve_3; cl15866 526227002846 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 526227002847 DNA-binding site [nucleotide binding]; DNA binding site 526227002848 RNA-binding motif; other site 526227002849 Fatty acid desaturase; Region: FA_desaturase; pfam00487 526227002850 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 526227002851 putative di-iron ligands [ion binding]; other site 526227002852 Survival protein SurE; Region: SurE; cl00448 526227002853 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227002854 binding surface 526227002855 Tetratricopeptide repeat; Region: TPR_16; pfam13432 526227002856 TPR motif; other site 526227002857 UPF0126 domain; Region: UPF0126; pfam03458 526227002858 UPF0126 domain; Region: UPF0126; pfam03458 526227002859 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 526227002860 homotrimer interaction site [polypeptide binding]; other site 526227002861 zinc binding site [ion binding]; other site 526227002862 CDP-binding sites; other site 526227002863 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 526227002864 FUN14 family; Region: FUN14; cl01015 526227002865 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 526227002866 Phosphate transporter family; Region: PHO4; cl00396 526227002867 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 526227002868 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 526227002869 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526227002870 active site 526227002871 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 526227002872 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 526227002873 dimer interface [polypeptide binding]; other site 526227002874 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227002875 catalytic residue [active] 526227002876 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 526227002877 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 526227002878 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 526227002879 metal ion-dependent adhesion site (MIDAS); other site 526227002880 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 526227002881 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 526227002882 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 526227002883 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 526227002884 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 526227002885 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 526227002886 Cysteine-rich domain; Region: CCG; pfam02754 526227002887 Cysteine-rich domain; Region: CCG; pfam02754 526227002888 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 526227002889 Putative esterase; Region: Esterase; pfam00756 526227002890 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526227002891 phosphorylation site [posttranslational modification] 526227002892 dimer interface [polypeptide binding]; other site 526227002893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227002894 ATP binding site [chemical binding]; other site 526227002895 Mg2+ binding site [ion binding]; other site 526227002896 G-X-G motif; other site 526227002897 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227002898 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526227002899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227002900 active site 526227002901 phosphorylation site [posttranslational modification] 526227002902 intermolecular recognition site; other site 526227002903 dimerization interface [polypeptide binding]; other site 526227002904 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526227002905 DNA binding site [nucleotide binding] 526227002906 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 526227002907 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 526227002908 putative substrate binding site [chemical binding]; other site 526227002909 putative ATP binding site [chemical binding]; other site 526227002910 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 526227002911 catalytic residue [active] 526227002912 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 526227002913 generic binding surface I; other site 526227002914 generic binding surface II; other site 526227002915 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 526227002916 putative active site [active] 526227002917 putative catalytic site [active] 526227002918 putative Mg binding site IVb [ion binding]; other site 526227002919 putative phosphate binding site [ion binding]; other site 526227002920 putative DNA binding site [nucleotide binding]; other site 526227002921 putative Mg binding site IVa [ion binding]; other site 526227002922 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 526227002923 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 526227002924 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227002925 NAD(P) binding site [chemical binding]; other site 526227002926 active site 526227002927 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 526227002928 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 526227002929 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 526227002930 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 526227002931 active site 526227002932 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 526227002933 putative active site [active] 526227002934 TPR repeat; Region: TPR_11; pfam13414 526227002935 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227002936 binding surface 526227002937 TPR motif; other site 526227002938 Transposase [DNA replication, recombination, and repair]; Region: COG5421 526227002939 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 526227002940 Low molecular weight phosphatase family; Region: LMWPc; cd00115 526227002941 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 526227002942 active site 526227002943 Low molecular weight phosphatase family; Region: LMWPc; cd00115 526227002944 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 526227002945 active site 526227002946 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 526227002947 oligoendopeptidase F; Region: pepF; TIGR00181 526227002948 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 526227002949 active site 526227002950 Zn binding site [ion binding]; other site 526227002951 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 526227002952 Probable transposase; Region: OrfB_IS605; pfam01385 526227002953 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 526227002954 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 526227002955 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 526227002956 active site 526227002957 catalytic triad [active] 526227002958 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 526227002959 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 526227002960 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 526227002961 cobalamin binding residues [chemical binding]; other site 526227002962 putative BtuC binding residues; other site 526227002963 dimer interface [polypeptide binding]; other site 526227002964 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 526227002965 structural tetrad; other site 526227002966 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 526227002967 structural tetrad; other site 526227002968 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 526227002969 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 526227002970 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 526227002971 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 526227002972 Isochorismatase family; Region: Isochorismatase; pfam00857 526227002973 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 526227002974 catalytic triad [active] 526227002975 conserved cis-peptide bond; other site 526227002976 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 526227002977 endonuclease III; Region: ENDO3c; smart00478 526227002978 minor groove reading motif; other site 526227002979 helix-hairpin-helix signature motif; other site 526227002980 substrate binding pocket [chemical binding]; other site 526227002981 active site 526227002982 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 526227002983 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 526227002984 histidinol-phosphatase; Provisional; Region: PRK07328 526227002985 hypothetical protein; Provisional; Region: PRK08609 526227002986 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 526227002987 metal binding triad [ion binding]; metal-binding site 526227002988 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 526227002989 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227002990 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 526227002991 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 526227002992 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 526227002993 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 526227002994 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 526227002995 E3 interaction surface; other site 526227002996 lipoyl attachment site [posttranslational modification]; other site 526227002997 e3 binding domain; Region: E3_binding; pfam02817 526227002998 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 526227002999 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 526227003000 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 526227003001 alpha subunit interface [polypeptide binding]; other site 526227003002 TPP binding site [chemical binding]; other site 526227003003 heterodimer interface [polypeptide binding]; other site 526227003004 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 526227003005 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 526227003006 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 526227003007 tetramer interface [polypeptide binding]; other site 526227003008 TPP-binding site [chemical binding]; other site 526227003009 heterodimer interface [polypeptide binding]; other site 526227003010 phosphorylation loop region [posttranslational modification] 526227003011 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 526227003012 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 526227003013 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 526227003014 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 526227003015 putative metal binding site [ion binding]; other site 526227003016 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 526227003017 active site 526227003018 metal binding site [ion binding]; metal-binding site 526227003019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227003020 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526227003021 putative substrate translocation pore; other site 526227003022 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 526227003023 Alkylmercury lyase; Region: MerB; pfam03243 526227003024 Transposase [DNA replication, recombination, and repair]; Region: COG5421 526227003025 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 526227003026 mercuric reductase; Region: MerA; TIGR02053 526227003027 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 526227003028 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 526227003029 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 526227003030 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 526227003031 metal-binding site [ion binding] 526227003032 Zn(II)-responsive transcriptional regulator; Region: ZntR; TIGR02043 526227003033 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 526227003034 DNA binding residues [nucleotide binding] 526227003035 dimer interface [polypeptide binding]; other site 526227003036 metal binding site [ion binding]; metal-binding site 526227003037 putative transposase OrfB; Reviewed; Region: PHA02517 526227003038 Integrase core domain; Region: rve; cl01316 526227003039 Integrase core domain; Region: rve_3; cl15866 526227003040 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 526227003041 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 526227003042 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227003043 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 526227003044 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 526227003045 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 526227003046 putative transposase OrfB; Reviewed; Region: PHA02517 526227003047 Integrase core domain; Region: rve; cl01316 526227003048 Integrase core domain; Region: rve_3; cl15866 526227003049 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 526227003050 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 526227003051 active site 526227003052 Zn binding site [ion binding]; other site 526227003053 C-terminal peptidase (prc); Region: prc; TIGR00225 526227003054 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 526227003055 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 526227003056 Domain interface; other site 526227003057 Peptide binding site; other site 526227003058 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 526227003059 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 526227003060 active site 526227003061 dimer interfaces [polypeptide binding]; other site 526227003062 catalytic residues [active] 526227003063 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 526227003064 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193 526227003065 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227003066 Walker A/P-loop; other site 526227003067 ATP binding site [chemical binding]; other site 526227003068 Q-loop/lid; other site 526227003069 ABC transporter signature motif; other site 526227003070 Walker B; other site 526227003071 D-loop; other site 526227003072 H-loop/switch region; other site 526227003073 Smr domain; Region: Smr; cl02619 526227003074 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 526227003075 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 526227003076 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 526227003077 active site 526227003078 homodimer interface [polypeptide binding]; other site 526227003079 catalytic site [active] 526227003080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227003081 dimer interface [polypeptide binding]; other site 526227003082 conserved gate region; other site 526227003083 putative PBP binding loops; other site 526227003084 ABC-ATPase subunit interface; other site 526227003085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 526227003086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227003087 putative PBP binding loops; other site 526227003088 ABC-ATPase subunit interface; other site 526227003089 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 526227003090 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227003091 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 526227003092 classical (c) SDR, subgroup 4; Region: SDR_c4; cd08929 526227003093 putative NAD(P) binding site [chemical binding]; other site 526227003094 homodimer interface [polypeptide binding]; other site 526227003095 active site 526227003096 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227003097 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227003098 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 526227003099 putative active site [active] 526227003100 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 526227003101 active site 526227003102 dimerization interface [polypeptide binding]; other site 526227003103 ribonuclease PH; Reviewed; Region: rph; PRK00173 526227003104 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 526227003105 oligomer interface [polypeptide binding]; other site 526227003106 RNA binding site [nucleotide binding]; other site 526227003107 putative transposase OrfB; Reviewed; Region: PHA02517 526227003108 Integrase core domain; Region: rve; cl01316 526227003109 Integrase core domain; Region: rve_3; cl15866 526227003110 integrase; Provisional; Region: int; PHA02601 526227003111 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 526227003112 Int/Topo IB signature motif; other site 526227003113 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 526227003114 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 526227003115 Probable transposase; Region: OrfB_IS605; pfam01385 526227003116 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 526227003117 Transposase IS200 like; Region: Y1_Tnp; cl00848 526227003118 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 526227003119 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 526227003120 Catalytic site [active] 526227003121 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 526227003122 non-specific DNA binding site [nucleotide binding]; other site 526227003123 salt bridge; other site 526227003124 sequence-specific DNA binding site [nucleotide binding]; other site 526227003125 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 526227003126 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227003127 Family description; Region: UvrD_C_2; cl15862 526227003128 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 526227003129 Domain of unknown function (DUF927); Region: DUF927; cl12098 526227003130 Terminase-like family; Region: Terminase_6; pfam03237 526227003131 Phage-related protein [Function unknown]; Region: COG4695; cl01923 526227003132 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 526227003133 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 526227003134 Probable transposase; Region: OrfB_IS605; pfam01385 526227003135 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 526227003136 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 526227003137 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227003138 Phage capsid family; Region: Phage_capsid; pfam05065 526227003139 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 526227003140 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 526227003141 Transcription factor/nuclear export subunit protein 2; Region: Tho2; pfam11262 526227003142 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 526227003143 active site 526227003144 metal binding site [ion binding]; metal-binding site 526227003145 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227003146 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227003147 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 526227003148 DEAD-like helicases superfamily; Region: DEXDc; smart00487 526227003149 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227003150 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 526227003151 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 526227003152 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 526227003153 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 526227003154 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 526227003155 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 526227003156 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 526227003157 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 526227003158 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 526227003159 putative transposase OrfB; Reviewed; Region: PHA02517 526227003160 Integrase core domain; Region: rve; cl01316 526227003161 Integrase core domain; Region: rve_3; cl15866 526227003162 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 526227003163 active site 526227003164 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 526227003165 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526227003166 polyphosphate kinase; Provisional; Region: PRK05443 526227003167 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 526227003168 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 526227003169 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 526227003170 putative active site [active] 526227003171 catalytic site [active] 526227003172 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 526227003173 putative active site [active] 526227003174 catalytic site [active] 526227003175 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 526227003176 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 526227003177 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 526227003178 catalytic core [active] 526227003179 CHAD domain; Region: CHAD; cl10506 526227003180 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526227003181 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 526227003182 dimer interface [polypeptide binding]; other site 526227003183 putative metal binding site [ion binding]; other site 526227003184 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 526227003185 enoyl-CoA hydratase; Provisional; Region: PRK06688 526227003186 substrate binding site [chemical binding]; other site 526227003187 oxyanion hole (OAH) forming residues; other site 526227003188 trimer interface [polypeptide binding]; other site 526227003189 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 526227003190 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 526227003191 Sulfatase; Region: Sulfatase; cl10460 526227003192 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 526227003193 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 526227003194 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 526227003195 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526227003196 MULE transposase domain; Region: MULE; pfam10551 526227003197 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 526227003198 ribosomal protein L20; Region: rpl20; CHL00068 526227003199 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 526227003200 23S rRNA binding site [nucleotide binding]; other site 526227003201 L21 binding site [polypeptide binding]; other site 526227003202 L13 binding site [polypeptide binding]; other site 526227003203 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 526227003204 Predicted dehydrogenase [General function prediction only]; Region: COG5322 526227003205 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227003206 NAD(P) binding pocket [chemical binding]; other site 526227003207 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 526227003208 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 526227003209 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 526227003210 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 526227003211 Protein of unknown function (DUF502); Region: DUF502; cl01107 526227003212 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526227003213 MULE transposase domain; Region: MULE; pfam10551 526227003214 Protein of unknown function (DUF456); Region: DUF456; cl01069 526227003215 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 526227003216 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 526227003217 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 526227003218 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 526227003219 Substrate binding site; other site 526227003220 Mg++ binding site; other site 526227003221 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 526227003222 active site 526227003223 substrate binding site [chemical binding]; other site 526227003224 CoA binding site [chemical binding]; other site 526227003225 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 526227003226 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 526227003227 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 526227003228 Chorismate mutase type II; Region: CM_2; cl00693 526227003229 NeuB family; Region: NeuB; cl00496 526227003230 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 526227003231 NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00160 526227003232 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 526227003233 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 526227003234 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 526227003235 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 526227003236 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 526227003237 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 526227003238 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 526227003239 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 526227003240 4Fe-4S binding domain; Region: Fer4; cl02805 526227003241 4Fe-4S binding domain; Region: Fer4; cl02805 526227003242 NADH dehydrogenase; Region: NADHdh; cl00469 526227003243 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 526227003244 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 526227003245 catalytic loop [active] 526227003246 iron binding site [ion binding]; other site 526227003247 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 526227003248 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 526227003249 molybdopterin cofactor binding site; other site 526227003250 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 526227003251 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 526227003252 SLBB domain; Region: SLBB; pfam10531 526227003253 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 526227003254 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 526227003255 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 526227003256 putative dimer interface [polypeptide binding]; other site 526227003257 [2Fe-2S] cluster binding site [ion binding]; other site 526227003258 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 526227003259 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 526227003260 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16919 526227003261 NADH dehydrogenase subunit B; Validated; Region: PRK06411 526227003262 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 526227003263 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 526227003264 AMP-binding enzyme; Region: AMP-binding; cl15778 526227003265 HipA N-terminal domain; Region: Couple_hipA; cl11853 526227003266 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 526227003267 putative peptidoglycan binding site; other site 526227003268 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 526227003269 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 526227003270 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 526227003271 homodimer interface [polypeptide binding]; other site 526227003272 substrate-cofactor binding pocket; other site 526227003273 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227003274 catalytic residue [active] 526227003275 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 526227003276 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 526227003277 ATP-grasp domain; Region: ATP-grasp_4; cl03087 526227003278 Domain of unknown function (DUF897); Region: DUF897; cl01312 526227003279 Nitrogen regulatory protein P-II; Region: P-II; smart00938 526227003280 AIR carboxylase; Region: AIRC; cl00310 526227003281 isocitrate dehydrogenase; Validated; Region: PRK09222 526227003282 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 526227003283 Integral membrane protein TerC family; Region: TerC; cl10468 526227003284 Integral membrane protein TerC family; Region: TerC; cl10468 526227003285 Integral membrane protein TerC family; Region: TerC; cl10468 526227003286 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 526227003287 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 526227003288 glutaminyl-tRNA synthetase/YqeY domain fusion protein; Provisional; Region: PRK14703 526227003289 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 526227003290 active site 526227003291 HIGH motif; other site 526227003292 nucleotide binding site [chemical binding]; other site 526227003293 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 526227003294 KMSKS motif; other site 526227003295 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 526227003296 GatB domain; Region: GatB_Yqey; cl11497 526227003297 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 526227003298 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 526227003299 active site 526227003300 catalytic site [active] 526227003301 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526227003302 MULE transposase domain; Region: MULE; pfam10551 526227003303 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 526227003304 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 526227003305 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227003306 UDP-galactopyranose mutase; Region: GLF; pfam03275 526227003307 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 526227003308 putative homodimer interface [polypeptide binding]; other site 526227003309 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 526227003310 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 526227003311 ligand binding site [chemical binding]; other site 526227003312 flexible hinge region; other site 526227003313 Helix-turn-helix domains; Region: HTH; cl00088 526227003314 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 526227003315 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 526227003316 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 526227003317 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 526227003318 putative hydrophobic ligand binding site [chemical binding]; other site 526227003319 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 526227003320 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 526227003321 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 526227003322 PHP-associated; Region: PHP_C; pfam13263 526227003323 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 526227003324 Domain of unknown function DUF20; Region: UPF0118; pfam01594 526227003325 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 526227003326 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 526227003327 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 526227003328 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 526227003329 effector binding site; other site 526227003330 dimer interface [polypeptide binding]; other site 526227003331 active site 526227003332 TSCPD domain; Region: TSCPD; cl14834 526227003333 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 526227003334 active site 526227003335 homodimer interface [polypeptide binding]; other site 526227003336 catalytic site [active] 526227003337 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 526227003338 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 526227003339 catalytic site [active] 526227003340 G-X2-G-X-G-K; other site 526227003341 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 526227003342 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 526227003343 arginine repressor; Region: argR_whole; TIGR01529 526227003344 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 526227003345 MarC family integral membrane protein; Region: MarC; cl00919 526227003346 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 526227003347 PAS domain; Region: PAS_9; pfam13426 526227003348 GAF domain; Region: GAF_2; pfam13185 526227003349 GAF domain; Region: GAF; cl15785 526227003350 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526227003351 metal binding site [ion binding]; metal-binding site 526227003352 active site 526227003353 I-site; other site 526227003354 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 526227003355 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227003356 Walker A/P-loop; other site 526227003357 ATP binding site [chemical binding]; other site 526227003358 Q-loop/lid; other site 526227003359 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 526227003360 ABC transporter signature motif; other site 526227003361 Walker B; other site 526227003362 D-loop; other site 526227003363 H-loop/switch region; other site 526227003364 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 526227003365 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 526227003366 active site residue [active] 526227003367 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 526227003368 active site residue [active] 526227003369 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 526227003370 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 526227003371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227003372 S-adenosylmethionine binding site [chemical binding]; other site 526227003373 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; cl01283 526227003374 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 526227003375 active site 526227003376 dimer interface [polypeptide binding]; other site 526227003377 metal binding site [ion binding]; metal-binding site 526227003378 shikimate kinase; Provisional; Region: PRK13948 526227003379 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 526227003380 ADP binding site [chemical binding]; other site 526227003381 magnesium binding site [ion binding]; other site 526227003382 putative shikimate binding site; other site 526227003383 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 526227003384 Tetramer interface [polypeptide binding]; other site 526227003385 active site 526227003386 FMN-binding site [chemical binding]; other site 526227003387 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 526227003388 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 526227003389 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 526227003390 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 526227003391 Pilus assembly protein, PilO; Region: PilO; cl01234 526227003392 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 526227003393 Cell division protein FtsA; Region: FtsA; cl11496 526227003394 tartrate dehydrogenase; Provisional; Region: PRK08194 526227003395 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 526227003396 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 526227003397 Zn2+ binding site [ion binding]; other site 526227003398 Mg2+ binding site [ion binding]; other site 526227003399 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 526227003400 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 526227003401 Probable Catalytic site; other site 526227003402 metal-binding site 526227003403 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 526227003404 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 526227003405 Predicted DNA-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG1571 526227003406 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 526227003407 polymerase nucleotide-binding site; other site 526227003408 DNA-binding residues [nucleotide binding]; DNA binding site 526227003409 nucleotide binding site [chemical binding]; other site 526227003410 primase nucleotide-binding site [nucleotide binding]; other site 526227003411 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227003412 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227003413 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 526227003414 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 526227003415 active site 526227003416 catalytic site [active] 526227003417 substrate binding site [chemical binding]; other site 526227003418 Phylum Aquificae Pol A is different from Escherichia coli Pol A by three signature sequences; Region: DNA_pol_A_Aquificae_like; cd08639 526227003419 active site 526227003420 DNA binding site [nucleotide binding] 526227003421 catalytic site [active] 526227003422 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 526227003423 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 526227003424 Int/Topo IB signature motif; other site 526227003425 putative transposase OrfB; Reviewed; Region: PHA02517 526227003426 Integrase core domain; Region: rve; cl01316 526227003427 Integrase core domain; Region: rve_3; cl15866 526227003428 2-phosphoglycerate kinase; Provisional; Region: PRK12337 526227003429 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 526227003430 Active site serine [active] 526227003431 Predicted amidohydrolase [General function prediction only]; Region: COG0388 526227003432 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 526227003433 active site 526227003434 catalytic triad [active] 526227003435 dimer interface [polypeptide binding]; other site 526227003436 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 526227003437 signal peptidase I; Provisional; Region: PRK10861 526227003438 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 526227003439 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 526227003440 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 526227003441 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526227003442 catalytic residue [active] 526227003443 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 526227003444 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227003445 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 526227003446 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 526227003447 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 526227003448 4Fe-4S binding domain; Region: Fer4; cl02805 526227003449 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 526227003450 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 526227003451 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 526227003452 putative active site [active] 526227003453 catalytic triad [active] 526227003454 putative dimer interface [polypeptide binding]; other site 526227003455 Preprotein translocase SecG subunit; Region: SecG; cl09123 526227003456 putative transposase OrfB; Reviewed; Region: PHA02517 526227003457 Integrase core domain; Region: rve; cl01316 526227003458 Integrase core domain; Region: rve_3; cl15866 526227003459 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 526227003460 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 526227003461 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 526227003462 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227003463 dimer interface [polypeptide binding]; other site 526227003464 conserved gate region; other site 526227003465 ABC-ATPase subunit interface; other site 526227003466 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 526227003467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227003468 dimer interface [polypeptide binding]; other site 526227003469 conserved gate region; other site 526227003470 putative PBP binding loops; other site 526227003471 ABC-ATPase subunit interface; other site 526227003472 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 526227003473 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 526227003474 Walker A/P-loop; other site 526227003475 ATP binding site [chemical binding]; other site 526227003476 Q-loop/lid; other site 526227003477 ABC transporter signature motif; other site 526227003478 Walker B; other site 526227003479 D-loop; other site 526227003480 H-loop/switch region; other site 526227003481 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 526227003482 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 526227003483 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 526227003484 Walker A/P-loop; other site 526227003485 ATP binding site [chemical binding]; other site 526227003486 Q-loop/lid; other site 526227003487 ABC transporter signature motif; other site 526227003488 Walker B; other site 526227003489 D-loop; other site 526227003490 H-loop/switch region; other site 526227003491 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 526227003492 Uncharacterized conserved protein [Function unknown]; Region: COG5316 526227003493 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 526227003494 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 526227003495 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 526227003496 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 526227003497 EamA-like transporter family; Region: EamA; cl01037 526227003498 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 526227003499 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 526227003500 recombination protein RecR; Reviewed; Region: recR; PRK00076 526227003501 RecR protein; Region: RecR; pfam02132 526227003502 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 526227003503 putative active site [active] 526227003504 putative metal-binding site [ion binding]; other site 526227003505 tetramer interface [polypeptide binding]; other site 526227003506 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 526227003507 H+ Antiporter protein; Region: 2A0121; TIGR00900 526227003508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227003509 putative substrate translocation pore; other site 526227003510 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 526227003511 Protein phosphatase 2C; Region: PP2C; pfam00481 526227003512 active site 526227003513 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 526227003514 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 526227003515 active site 526227003516 ATP binding site [chemical binding]; other site 526227003517 substrate binding site [chemical binding]; other site 526227003518 activation loop (A-loop); other site 526227003519 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 526227003520 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 526227003521 catalytic triad [active] 526227003522 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 526227003523 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227003524 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 526227003525 DNA photolyase; Region: DNA_photolyase; pfam00875 526227003526 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 526227003527 Fasciclin domain; Region: Fasciclin; cl02663 526227003528 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227003529 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227003530 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 526227003531 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 526227003532 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 526227003533 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526227003534 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 526227003535 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 526227003536 Walker A/P-loop; other site 526227003537 ATP binding site [chemical binding]; other site 526227003538 Q-loop/lid; other site 526227003539 ABC transporter signature motif; other site 526227003540 Walker B; other site 526227003541 D-loop; other site 526227003542 H-loop/switch region; other site 526227003543 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 526227003544 ABC-ATPase subunit interface; other site 526227003545 dimer interface [polypeptide binding]; other site 526227003546 putative PBP binding regions; other site 526227003547 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 526227003548 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 526227003549 intersubunit interface [polypeptide binding]; other site 526227003550 putative transposase OrfB; Reviewed; Region: PHA02517 526227003551 Integrase core domain; Region: rve; cl01316 526227003552 Integrase core domain; Region: rve_3; cl15866 526227003553 YceI-like domain; Region: YceI; cl01001 526227003554 Helix-turn-helix domains; Region: HTH; cl00088 526227003555 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526227003556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227003557 active site 526227003558 phosphorylation site [posttranslational modification] 526227003559 intermolecular recognition site; other site 526227003560 dimerization interface [polypeptide binding]; other site 526227003561 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526227003562 DNA binding site [nucleotide binding] 526227003563 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 526227003564 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526227003565 dimer interface [polypeptide binding]; other site 526227003566 phosphorylation site [posttranslational modification] 526227003567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227003568 ATP binding site [chemical binding]; other site 526227003569 Mg2+ binding site [ion binding]; other site 526227003570 G-X-G motif; other site 526227003571 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 526227003572 Cu(I) binding site [ion binding]; other site 526227003573 Copper type II ascorbate-dependent monooxygenase, N-terminal domain; Region: Cu2_monooxygen; pfam01082 526227003574 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 526227003575 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 526227003576 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 526227003577 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227003578 Family description; Region: UvrD_C_2; cl15862 526227003579 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 526227003580 OsmC-like protein; Region: OsmC; cl00767 526227003581 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 526227003582 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 526227003583 inhibitor-cofactor binding pocket; inhibition site 526227003584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227003585 catalytic residue [active] 526227003586 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 526227003587 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 526227003588 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 526227003589 active site 526227003590 metal binding site [ion binding]; metal-binding site 526227003591 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 526227003592 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 526227003593 putative RNA binding site [nucleotide binding]; other site 526227003594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 526227003595 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 526227003596 glycogen binding site [chemical binding]; other site 526227003597 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 526227003598 carbohydrate binding site [chemical binding]; other site 526227003599 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 526227003600 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 526227003601 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 526227003602 Ca binding site [ion binding]; other site 526227003603 active site 526227003604 catalytic site [active] 526227003605 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 526227003606 maltodextrin glucosidase; Provisional; Region: PRK10785 526227003607 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 526227003608 active site 526227003609 homodimer interface [polypeptide binding]; other site 526227003610 catalytic site [active] 526227003611 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 526227003612 AzlC protein; Region: AzlC; cl00570 526227003613 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 526227003614 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 526227003615 active site 526227003616 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 526227003617 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 526227003618 Walker A/P-loop; other site 526227003619 ATP binding site [chemical binding]; other site 526227003620 Q-loop/lid; other site 526227003621 ABC transporter signature motif; other site 526227003622 Walker B; other site 526227003623 D-loop; other site 526227003624 H-loop/switch region; other site 526227003625 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 526227003626 C-terminal peptidase (prc); Region: prc; TIGR00225 526227003627 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 526227003628 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 526227003629 Catalytic dyad [active] 526227003630 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 526227003631 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227003632 Walker A/P-loop; other site 526227003633 ATP binding site [chemical binding]; other site 526227003634 Q-loop/lid; other site 526227003635 ABC transporter signature motif; other site 526227003636 Walker B; other site 526227003637 D-loop; other site 526227003638 H-loop/switch region; other site 526227003639 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 526227003640 30S subunit binding site; other site 526227003641 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 526227003642 Peptidase family M23; Region: Peptidase_M23; pfam01551 526227003643 FtsX-like permease family; Region: FtsX; cl15850 526227003644 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 526227003645 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 526227003646 MOFRL family; Region: MOFRL; pfam05161 526227003647 Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250 526227003648 Kelch motif; Region: Kelch_1; cl02701 526227003649 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 526227003650 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 526227003651 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 526227003652 Cysteine-rich domain; Region: CCG; pfam02754 526227003653 Cysteine-rich domain; Region: CCG; pfam02754 526227003654 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 526227003655 FAD binding domain; Region: FAD_binding_4; pfam01565 526227003656 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 526227003657 FAD binding domain; Region: FAD_binding_4; pfam01565 526227003658 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 526227003659 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 526227003660 MoxR-like ATPases [General function prediction only]; Region: COG0714 526227003661 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227003662 Walker A motif; other site 526227003663 ATP binding site [chemical binding]; other site 526227003664 Walker B motif; other site 526227003665 arginine finger; other site 526227003666 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 526227003667 malate synthase A; Region: malate_syn_A; TIGR01344 526227003668 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 526227003669 active site 526227003670 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 526227003671 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 526227003672 putative Iron-sulfur protein interface [polypeptide binding]; other site 526227003673 putative proximal heme binding site [chemical binding]; other site 526227003674 putative SdhD-like interface [polypeptide binding]; other site 526227003675 putative distal heme binding site [chemical binding]; other site 526227003676 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 526227003677 Iron-sulfur protein interface; other site 526227003678 proximal heme binding site [chemical binding]; other site 526227003679 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 526227003680 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227003681 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 526227003682 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 526227003683 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 526227003684 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 526227003685 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 526227003686 Dynamin family; Region: Dynamin_N; pfam00350 526227003687 G1 box; other site 526227003688 GTP/Mg2+ binding site [chemical binding]; other site 526227003689 G2 box; other site 526227003690 Switch I region; other site 526227003691 G3 box; other site 526227003692 Switch II region; other site 526227003693 G4 box; other site 526227003694 G5 box; other site 526227003695 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 526227003696 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 526227003697 AMP-binding enzyme; Region: AMP-binding; cl15778 526227003698 AMP-binding enzyme; Region: AMP-binding; cl15778 526227003699 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 526227003700 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 526227003701 Catalytic domain of Protein Kinases; Region: PKc; cd00180 526227003702 active site 526227003703 ATP binding site [chemical binding]; other site 526227003704 substrate binding site [chemical binding]; other site 526227003705 activation loop (A-loop); other site 526227003706 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 526227003707 Protein of unknown function (DUF3809); Region: DUF3809; pfam12723 526227003708 Protein of unknown function (DUF3248); Region: DUF3248; pfam11609 526227003709 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 526227003710 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 526227003711 putative RNA binding site [nucleotide binding]; other site 526227003712 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227003713 S-adenosylmethionine binding site [chemical binding]; other site 526227003714 V-type ATP synthase subunit I; Validated; Region: PRK05771 526227003715 Plant ATP synthase F0; Region: YMF19; cl07975 526227003716 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 526227003717 ATP synthase (C/AC39) subunit; Region: vATP-synt_AC39; pfam01992 526227003718 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632 526227003719 V-type ATP synthase subunit A; Provisional; Region: PRK04192 526227003720 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 526227003721 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 526227003722 Walker A motif/ATP binding site; other site 526227003723 Walker B motif; other site 526227003724 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 526227003725 V-type ATP synthase subunit B; Provisional; Region: PRK04196 526227003726 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 526227003727 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 526227003728 Walker A motif homologous position; other site 526227003729 Walker B motif; other site 526227003730 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 526227003731 ATP synthase subunit D; Region: ATP-synt_D; cl00613 526227003732 Pectinacetylesterase; Region: PAE; pfam03283 526227003733 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 526227003734 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 526227003735 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 526227003736 generic binding surface II; other site 526227003737 ssDNA binding site; other site 526227003738 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526227003739 ATP binding site [chemical binding]; other site 526227003740 putative Mg++ binding site [ion binding]; other site 526227003741 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526227003742 nucleotide binding region [chemical binding]; other site 526227003743 ATP-binding site [chemical binding]; other site 526227003744 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 526227003745 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 526227003746 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 526227003747 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 526227003748 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 526227003749 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 526227003750 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 526227003751 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227003752 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227003753 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 526227003754 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227003755 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 526227003756 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 526227003757 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526227003758 MULE transposase domain; Region: MULE; pfam10551 526227003759 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526227003760 active site 526227003761 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 526227003762 Protein export membrane protein; Region: SecD_SecF; cl14618 526227003763 Protein export membrane protein; Region: SecD_SecF; cl14618 526227003764 translation initiation factor IF-2; Region: IF-2; TIGR00487 526227003765 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 526227003766 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 526227003767 G1 box; other site 526227003768 putative GEF interaction site [polypeptide binding]; other site 526227003769 GTP/Mg2+ binding site [chemical binding]; other site 526227003770 Switch I region; other site 526227003771 G2 box; other site 526227003772 G3 box; other site 526227003773 Switch II region; other site 526227003774 G4 box; other site 526227003775 G5 box; other site 526227003776 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 526227003777 Translation-initiation factor 2; Region: IF-2; pfam11987 526227003778 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 526227003779 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 526227003780 putative RNA binding cleft [nucleotide binding]; other site 526227003781 transcription termination factor NusA; Region: NusA; TIGR01953 526227003782 NusA N-terminal domain; Region: NusA_N; pfam08529 526227003783 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 526227003784 RNA binding site [nucleotide binding]; other site 526227003785 homodimer interface [polypeptide binding]; other site 526227003786 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 526227003787 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 526227003788 G-X-X-G motif; other site 526227003789 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 526227003790 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 526227003791 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 526227003792 Sm1 motif; other site 526227003793 RNA binding pocket [nucleotide binding]; other site 526227003794 Cupin domain; Region: Cupin_2; cl09118 526227003795 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 526227003796 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 526227003797 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 526227003798 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK14811 526227003799 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 526227003800 DNA binding site [nucleotide binding] 526227003801 catalytic residue [active] 526227003802 H2TH interface [polypeptide binding]; other site 526227003803 putative catalytic residues [active] 526227003804 turnover-facilitating residue; other site 526227003805 intercalation triad [nucleotide binding]; other site 526227003806 8OG recognition residue [nucleotide binding]; other site 526227003807 putative reading head residues; other site 526227003808 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 526227003809 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 526227003810 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 526227003811 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 526227003812 putative NAD(P) binding site [chemical binding]; other site 526227003813 active site 526227003814 CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918 526227003815 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 526227003816 ligand binding site [chemical binding]; other site 526227003817 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 526227003818 putative switch regulator; other site 526227003819 non-specific DNA interactions [nucleotide binding]; other site 526227003820 DNA binding site [nucleotide binding] 526227003821 sequence specific DNA binding site [nucleotide binding]; other site 526227003822 putative cAMP binding site [chemical binding]; other site 526227003823 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 526227003824 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 526227003825 DNA binding residues [nucleotide binding] 526227003826 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 526227003827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 526227003828 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 526227003829 active site lid residues [active] 526227003830 substrate binding pocket [chemical binding]; other site 526227003831 catalytic residues [active] 526227003832 substrate-Mg2+ binding site; other site 526227003833 aspartate-rich region 1; other site 526227003834 aspartate-rich region 2; other site 526227003835 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 526227003836 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227003837 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227003838 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 526227003839 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227003840 Protein of unknown function (DUF422); Region: DUF422; cl00991 526227003841 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 526227003842 putative acyl-acceptor binding pocket; other site 526227003843 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 526227003844 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 526227003845 active site 526227003846 phytoene desaturase; Region: crtI_fam; TIGR02734 526227003847 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 526227003848 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 526227003849 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 526227003850 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 526227003851 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 526227003852 homotetramer interface [polypeptide binding]; other site 526227003853 FMN binding site [chemical binding]; other site 526227003854 homodimer contacts [polypeptide binding]; other site 526227003855 putative active site [active] 526227003856 putative substrate binding site [chemical binding]; other site 526227003857 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227003858 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227003859 putative transposase OrfB; Reviewed; Region: PHA02517 526227003860 Integrase core domain; Region: rve; cl01316 526227003861 Integrase core domain; Region: rve_3; cl15866 526227003862 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227003863 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227003864 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227003865 TPR motif; other site 526227003866 binding surface 526227003867 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 526227003868 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227003869 binding surface 526227003870 TPR motif; other site 526227003871 Sporulation related domain; Region: SPOR; cl10051 526227003872 Sporulation related domain; Region: SPOR; cl10051 526227003873 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 526227003874 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 526227003875 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227003876 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 526227003877 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 526227003878 substrate binding pocket [chemical binding]; other site 526227003879 chain length determination region; other site 526227003880 substrate-Mg2+ binding site; other site 526227003881 catalytic residues [active] 526227003882 aspartate-rich region 1; other site 526227003883 active site lid residues [active] 526227003884 aspartate-rich region 2; other site 526227003885 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 526227003886 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 526227003887 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 526227003888 NAD(P) binding site [chemical binding]; other site 526227003889 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 526227003890 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 526227003891 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 526227003892 NAD(P) binding site [chemical binding]; other site 526227003893 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 526227003894 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 526227003895 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 526227003896 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227003897 Methyltransferase domain; Region: Methyltransf_31; pfam13847 526227003898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227003899 S-adenosylmethionine binding site [chemical binding]; other site 526227003900 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 526227003901 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 526227003902 GIY-YIG motif/motif A; other site 526227003903 active site 526227003904 catalytic site [active] 526227003905 putative DNA binding site [nucleotide binding]; other site 526227003906 metal binding site [ion binding]; metal-binding site 526227003907 UvrB/uvrC motif; Region: UVR; pfam02151 526227003908 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 526227003909 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 526227003910 NADH-quinone oxidoreductase chain 15; Region: NADH_Oxid_Nqo15; pfam11497 526227003911 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 526227003912 substrate binding site [chemical binding]; other site 526227003913 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 526227003914 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 526227003915 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 526227003916 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 526227003917 P loop; other site 526227003918 GTP binding site [chemical binding]; other site 526227003919 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 526227003920 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 526227003921 HIGH motif; other site 526227003922 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 526227003923 active site 526227003924 KMSKS motif; other site 526227003925 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 526227003926 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 526227003927 Walker A/P-loop; other site 526227003928 ATP binding site [chemical binding]; other site 526227003929 Q-loop/lid; other site 526227003930 ABC transporter signature motif; other site 526227003931 Walker B; other site 526227003932 D-loop; other site 526227003933 H-loop/switch region; other site 526227003934 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 526227003935 ornithine cyclodeaminase; Validated; Region: PRK07340 526227003936 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227003937 NAD(P) binding pocket [chemical binding]; other site 526227003938 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 526227003939 MutS domain I; Region: MutS_I; pfam01624 526227003940 MutS domain II; Region: MutS_II; pfam05188 526227003941 MutS family domain IV; Region: MutS_IV; pfam05190 526227003942 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 526227003943 Walker A/P-loop; other site 526227003944 ATP binding site [chemical binding]; other site 526227003945 Q-loop/lid; other site 526227003946 ABC transporter signature motif; other site 526227003947 Walker B; other site 526227003948 D-loop; other site 526227003949 H-loop/switch region; other site 526227003950 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 526227003951 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227003952 ATP binding site [chemical binding]; other site 526227003953 Mg2+ binding site [ion binding]; other site 526227003954 G-X-G motif; other site 526227003955 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 526227003956 ATP binding site [chemical binding]; other site 526227003957 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 526227003958 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 526227003959 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 526227003960 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 526227003961 putative active site [active] 526227003962 putative substrate binding site [chemical binding]; other site 526227003963 putative cosubstrate binding site; other site 526227003964 catalytic site [active] 526227003965 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 526227003966 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 526227003967 protein binding site [polypeptide binding]; other site 526227003968 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 526227003969 NMT1-like family; Region: NMT1_2; cl15260 526227003970 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 526227003971 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 526227003972 FeS/SAM binding site; other site 526227003973 Transcriptional regulators [Transcription]; Region: PurR; COG1609 526227003974 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 526227003975 DNA binding site [nucleotide binding] 526227003976 domain linker motif; other site 526227003977 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 526227003978 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 526227003979 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 526227003980 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227003981 Walker A/P-loop; other site 526227003982 ATP binding site [chemical binding]; other site 526227003983 Q-loop/lid; other site 526227003984 ABC transporter signature motif; other site 526227003985 Walker B; other site 526227003986 D-loop; other site 526227003987 H-loop/switch region; other site 526227003988 ABC transporter; Region: ABC_tran_2; pfam12848 526227003989 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 526227003990 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 526227003991 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 526227003992 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 526227003993 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 526227003994 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 526227003995 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 526227003996 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 526227003997 active site 526227003998 substrate binding site [chemical binding]; other site 526227003999 cosubstrate binding site; other site 526227004000 catalytic site [active] 526227004001 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 526227004002 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 526227004003 ATP-grasp domain; Region: ATP-grasp_4; cl03087 526227004004 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 526227004005 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 526227004006 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 526227004007 active site 526227004008 dimerization interface [polypeptide binding]; other site 526227004009 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 526227004010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227004011 S-adenosylmethionine binding site [chemical binding]; other site 526227004012 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 526227004013 G-X-X-G motif; other site 526227004014 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 526227004015 RxxxH motif; other site 526227004016 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 526227004017 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 526227004018 Haemolytic domain; Region: Haemolytic; cl00506 526227004019 Ribonuclease P; Region: Ribonuclease_P; cl00457 526227004020 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 526227004021 putative transposase OrfB; Reviewed; Region: PHA02517 526227004022 Integrase core domain; Region: rve; cl01316 526227004023 Integrase core domain; Region: rve_3; cl15866 526227004024 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 526227004025 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 526227004026 Walker A/P-loop; other site 526227004027 ATP binding site [chemical binding]; other site 526227004028 Q-loop/lid; other site 526227004029 ABC transporter signature motif; other site 526227004030 Walker B; other site 526227004031 D-loop; other site 526227004032 H-loop/switch region; other site 526227004033 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 526227004034 AMP-binding enzyme; Region: AMP-binding; cl15778 526227004035 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 526227004036 TM-ABC transporter signature motif; other site 526227004037 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 526227004038 TM-ABC transporter signature motif; other site 526227004039 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 526227004040 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 526227004041 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 526227004042 Walker A/P-loop; other site 526227004043 ATP binding site [chemical binding]; other site 526227004044 Q-loop/lid; other site 526227004045 ABC transporter signature motif; other site 526227004046 Walker B; other site 526227004047 D-loop; other site 526227004048 H-loop/switch region; other site 526227004049 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 526227004050 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 526227004051 Helix-turn-helix domains; Region: HTH; cl00088 526227004052 septum site-determining protein MinD; Region: minD_bact; TIGR01968 526227004053 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 526227004054 Switch I; other site 526227004055 Switch II; other site 526227004056 Septum formation topological specificity factor MinE; Region: MinE; cl00538 526227004057 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 526227004058 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 526227004059 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227004060 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 526227004061 Walker A/P-loop; other site 526227004062 ATP binding site [chemical binding]; other site 526227004063 Q-loop/lid; other site 526227004064 ABC transporter signature motif; other site 526227004065 Walker B; other site 526227004066 D-loop; other site 526227004067 H-loop/switch region; other site 526227004068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227004069 dimer interface [polypeptide binding]; other site 526227004070 conserved gate region; other site 526227004071 putative PBP binding loops; other site 526227004072 ABC-ATPase subunit interface; other site 526227004073 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 526227004074 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227004075 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 526227004076 Moco binding site; other site 526227004077 TOBE domain; Region: TOBE_2; cl01440 526227004078 Helix-turn-helix domains; Region: HTH; cl00088 526227004079 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 526227004080 homodimer interaction site [polypeptide binding]; other site 526227004081 cofactor binding site; other site 526227004082 Cytochrome c; Region: Cytochrom_C; cl11414 526227004083 putative transposase OrfB; Reviewed; Region: PHA02517 526227004084 Integrase core domain; Region: rve; cl01316 526227004085 Integrase core domain; Region: rve_3; cl15866 526227004086 Cytochrome c; Region: Cytochrom_C; cl11414 526227004087 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 526227004088 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227004089 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227004090 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 526227004091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227004092 ABC-ATPase subunit interface; other site 526227004093 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 526227004094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227004095 dimer interface [polypeptide binding]; other site 526227004096 conserved gate region; other site 526227004097 putative PBP binding loops; other site 526227004098 ABC-ATPase subunit interface; other site 526227004099 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 526227004100 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227004101 Walker A/P-loop; other site 526227004102 ATP binding site [chemical binding]; other site 526227004103 Q-loop/lid; other site 526227004104 ABC transporter signature motif; other site 526227004105 Walker B; other site 526227004106 D-loop; other site 526227004107 H-loop/switch region; other site 526227004108 TOBE domain; Region: TOBE_2; cl01440 526227004109 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 526227004110 metal ion-dependent adhesion site (MIDAS); other site 526227004111 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 526227004112 active site 526227004113 catalytic residues [active] 526227004114 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 526227004115 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 526227004116 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 526227004117 Int/Topo IB signature motif; other site 526227004118 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 526227004119 polymerase nucleotide-binding site; other site 526227004120 DNA-binding residues [nucleotide binding]; DNA binding site 526227004121 nucleotide binding site [chemical binding]; other site 526227004122 primase nucleotide-binding site [nucleotide binding]; other site 526227004123 Domain of unknown function (DUF927); Region: DUF927; cl12098 526227004124 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 526227004125 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 526227004126 active site 526227004127 catalytic site [active] 526227004128 substrate binding site [chemical binding]; other site 526227004129 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 526227004130 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 526227004131 ligand binding site [chemical binding]; other site 526227004132 flexible hinge region; other site 526227004133 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 526227004134 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 526227004135 metal binding triad; other site 526227004136 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227004137 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227004138 Transcriptional regulator [Transcription]; Region: IclR; COG1414 526227004139 Helix-turn-helix domains; Region: HTH; cl00088 526227004140 Bacterial transcriptional regulator; Region: IclR; pfam01614 526227004141 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 526227004142 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 526227004143 AMP-binding enzyme; Region: AMP-binding; cl15778 526227004144 acetyl-CoA synthetase; Provisional; Region: PRK00174 526227004145 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 526227004146 AMP-binding enzyme; Region: AMP-binding; cl15778 526227004147 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 526227004148 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 526227004149 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 526227004150 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 526227004151 ABC-ATPase subunit interface; other site 526227004152 dimer interface [polypeptide binding]; other site 526227004153 putative PBP binding regions; other site 526227004154 Helix-turn-helix domains; Region: HTH; cl00088 526227004155 Rrf2 family protein; Region: rrf2_super; TIGR00738 526227004156 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 526227004157 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 526227004158 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526227004159 catalytic residue [active] 526227004160 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 526227004161 AMP-binding enzyme; Region: AMP-binding; cl15778 526227004162 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 526227004163 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 526227004164 active site 526227004165 Cupin domain; Region: Cupin_2; cl09118 526227004166 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 526227004167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227004168 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 526227004169 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 526227004170 metal binding site [ion binding]; metal-binding site 526227004171 dimer interface [polypeptide binding]; other site 526227004172 Dehydratase family; Region: ILVD_EDD; cl00340 526227004173 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 526227004174 classical (c) SDRs; Region: SDR_c; cd05233 526227004175 NAD(P) binding site [chemical binding]; other site 526227004176 active site 526227004177 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 526227004178 tartrate dehydrogenase; Provisional; Region: PRK08194 526227004179 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 526227004180 substrate binding site [chemical binding]; other site 526227004181 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 526227004182 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 526227004183 substrate binding site [chemical binding]; other site 526227004184 ligand binding site [chemical binding]; other site 526227004185 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227004186 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 526227004187 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 526227004188 protein binding site [polypeptide binding]; other site 526227004189 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 526227004190 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 526227004191 active site 526227004192 HIGH motif; other site 526227004193 dimer interface [polypeptide binding]; other site 526227004194 KMSKS motif; other site 526227004195 ScpA/B protein; Region: ScpA_ScpB; cl00598 526227004196 putative acyltransferase; Provisional; Region: PRK05790 526227004197 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 526227004198 dimer interface [polypeptide binding]; other site 526227004199 active site 526227004200 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 526227004201 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227004202 prephenate dehydrogenase; Validated; Region: PRK06545 526227004203 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 526227004204 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 526227004205 CoenzymeA binding site [chemical binding]; other site 526227004206 subunit interaction site [polypeptide binding]; other site 526227004207 PHB binding site; other site 526227004208 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 526227004209 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 526227004210 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526227004211 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 526227004212 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 526227004213 Permutation of conserved domain; other site 526227004214 active site 526227004215 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 526227004216 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 526227004217 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 526227004218 nucleoside/Zn binding site; other site 526227004219 dimer interface [polypeptide binding]; other site 526227004220 catalytic motif [active] 526227004221 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 526227004222 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 526227004223 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 526227004224 ATP binding site [chemical binding]; other site 526227004225 substrate interface [chemical binding]; other site 526227004226 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 526227004227 dimer interface [polypeptide binding]; other site 526227004228 Citrate synthase; Region: Citrate_synt; pfam00285 526227004229 active site 526227004230 coenzyme A binding site [chemical binding]; other site 526227004231 citrylCoA binding site [chemical binding]; other site 526227004232 oxalacetate/citrate binding site [chemical binding]; other site 526227004233 catalytic triad [active] 526227004234 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 526227004235 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 526227004236 Predicted membrane protein [Function unknown]; Region: COG1470 526227004237 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 526227004238 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 526227004239 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 526227004240 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227004241 Walker A/P-loop; other site 526227004242 ATP binding site [chemical binding]; other site 526227004243 Q-loop/lid; other site 526227004244 ABC transporter signature motif; other site 526227004245 Walker B; other site 526227004246 D-loop; other site 526227004247 H-loop/switch region; other site 526227004248 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 526227004249 ABC-2 type transporter; Region: ABC2_membrane; cl11417 526227004250 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 526227004251 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 526227004252 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 526227004253 metal-binding site [ion binding] 526227004254 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 526227004255 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 526227004256 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526227004257 dimerization interface [polypeptide binding]; other site 526227004258 putative DNA binding site [nucleotide binding]; other site 526227004259 putative Zn2+ binding site [ion binding]; other site 526227004260 DDE superfamily endonuclease; Region: DDE_4; cl15789 526227004261 DDE superfamily endonuclease; Region: DDE_4; cl15789 526227004262 GAF domain; Region: GAF; cl15785 526227004263 GAF domain; Region: GAF; cl15785 526227004264 GAF domain; Region: GAF_2; pfam13185 526227004265 GAF domain; Region: GAF_2; pfam13185 526227004266 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526227004267 metal binding site [ion binding]; metal-binding site 526227004268 active site 526227004269 I-site; other site 526227004270 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 526227004271 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227004272 imidazolonepropionase; Validated; Region: PRK09356 526227004273 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 526227004274 active site 526227004275 urocanate hydratase; Provisional; Region: PRK05414 526227004276 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 526227004277 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 526227004278 DNA-binding site [nucleotide binding]; DNA binding site 526227004279 UTRA domain; Region: UTRA; cl01230 526227004280 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 526227004281 active sites [active] 526227004282 tetramer interface [polypeptide binding]; other site 526227004283 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 526227004284 MoxR-like ATPases [General function prediction only]; Region: COG0714 526227004285 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227004286 Walker A motif; other site 526227004287 ATP binding site [chemical binding]; other site 526227004288 Walker B motif; other site 526227004289 arginine finger; other site 526227004290 heavy metal efflux pump (cobalt-zinc-cadmium); Region: 2A0601; TIGR00914 526227004291 UGMP family protein; Validated; Region: PRK09604 526227004292 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 526227004293 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 526227004294 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 526227004295 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 526227004296 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 526227004297 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 526227004298 putative active site [active] 526227004299 putative metal binding site [ion binding]; other site 526227004300 Transcriptional regulator; Region: Transcrip_reg; cl00361 526227004301 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 526227004302 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 526227004303 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 526227004304 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 526227004305 comF family protein; Region: comF; TIGR00201 526227004306 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 526227004307 active site 526227004308 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 526227004309 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 526227004310 active site 526227004311 Riboflavin kinase; Region: Flavokinase; cl03312 526227004312 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 526227004313 dimer interface [polypeptide binding]; other site 526227004314 ADP-ribose binding site [chemical binding]; other site 526227004315 active site 526227004316 nudix motif; other site 526227004317 metal binding site [ion binding]; metal-binding site 526227004318 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 526227004319 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 526227004320 active site 526227004321 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 526227004322 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 526227004323 Uncharacterized conserved protein [Function unknown]; Region: COG1432 526227004324 LabA_like proteins; Region: LabA; cd10911 526227004325 putative metal binding site [ion binding]; other site 526227004326 Protein kinase domain; Region: Pkinase; pfam00069 526227004327 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 526227004328 active site 526227004329 ATP binding site [chemical binding]; other site 526227004330 substrate binding site [chemical binding]; other site 526227004331 activation loop (A-loop); other site 526227004332 hypothetical protein; Provisional; Region: PRK10279 526227004333 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 526227004334 active site 526227004335 nucleophile elbow; other site 526227004336 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 526227004337 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 526227004338 Catalytic site [active] 526227004339 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 526227004340 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 526227004341 active site 526227004342 HslU subunit interaction site [polypeptide binding]; other site 526227004343 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 526227004344 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227004345 Walker A motif; other site 526227004346 ATP binding site [chemical binding]; other site 526227004347 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227004348 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 526227004349 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227004350 TPR motif; other site 526227004351 binding surface 526227004352 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227004353 binding surface 526227004354 TPR motif; other site 526227004355 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227004356 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227004357 Tetratricopeptide repeat; Region: TPR_16; pfam13432 526227004358 TPR motif; other site 526227004359 binding surface 526227004360 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227004361 binding surface 526227004362 TPR motif; other site 526227004363 TPR repeat; Region: TPR_11; pfam13414 526227004364 NurA domain; Region: NurA; cl09134 526227004365 HerA helicase [Replication, recombination, and repair]; Region: COG0433 526227004366 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 526227004367 active site 526227004368 putative DNA-binding cleft [nucleotide binding]; other site 526227004369 dimer interface [polypeptide binding]; other site 526227004370 cell division protein FtsZ; Validated; Region: PRK09330 526227004371 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 526227004372 nucleotide binding site [chemical binding]; other site 526227004373 SulA interaction site; other site 526227004374 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 526227004375 Cell division protein FtsA; Region: FtsA; cl11496 526227004376 Cell division protein FtsA; Region: FtsA; cl11496 526227004377 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 526227004378 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14651 526227004379 FAD binding domain; Region: FAD_binding_4; pfam01565 526227004380 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 526227004381 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 526227004382 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 526227004383 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 526227004384 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 526227004385 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 526227004386 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 526227004387 active site 526227004388 homodimer interface [polypeptide binding]; other site 526227004389 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 526227004390 UDP-N-acetylmuramoylalanine--D-glutamate ligase; Region: murD; TIGR01087 526227004391 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 526227004392 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 526227004393 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 526227004394 Mg++ binding site [ion binding]; other site 526227004395 putative catalytic motif [active] 526227004396 putative substrate binding site [chemical binding]; other site 526227004397 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 526227004398 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 526227004399 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 526227004400 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 526227004401 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 526227004402 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 526227004403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 526227004404 cell division protein MraZ; Reviewed; Region: PRK00326 526227004405 MraZ protein; Region: MraZ; pfam02381 526227004406 MraZ protein; Region: MraZ; pfam02381 526227004407 isocitrate dehydrogenase; Validated; Region: PRK07362 526227004408 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 526227004409 CAAX protease self-immunity; Region: Abi; cl00558 526227004410 Helix-turn-helix domains; Region: HTH; cl00088 526227004411 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 526227004412 active site 526227004413 metal binding site [ion binding]; metal-binding site 526227004414 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 526227004415 Fibronectin type III-like domain; Region: Fn3-like; cl15273 526227004416 putative transposase OrfB; Reviewed; Region: PHA02517 526227004417 Integrase core domain; Region: rve; cl01316 526227004418 Integrase core domain; Region: rve_3; cl15866 526227004419 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227004420 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227004421 RecX family; Region: RecX; cl00936 526227004422 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526227004423 MULE transposase domain; Region: MULE; pfam10551 526227004424 RecX family; Region: RecX; cl00936 526227004425 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227004426 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 526227004427 hydrophobic ligand binding site; other site 526227004428 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 526227004429 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 526227004430 active site 526227004431 HIGH motif; other site 526227004432 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 526227004433 KMSKS motif; other site 526227004434 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 526227004435 tRNA binding surface [nucleotide binding]; other site 526227004436 anticodon binding site; other site 526227004437 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 526227004438 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 526227004439 putative transposase OrfB; Reviewed; Region: PHA02517 526227004440 Integrase core domain; Region: rve; cl01316 526227004441 Integrase core domain; Region: rve_3; cl15866 526227004442 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 526227004443 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 526227004444 active site 526227004445 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 526227004446 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 526227004447 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 526227004448 active site 526227004449 FMN binding site [chemical binding]; other site 526227004450 substrate binding site [chemical binding]; other site 526227004451 3Fe-4S cluster binding site [ion binding]; other site 526227004452 Glutamate synthase domain 3 [Amino acid transport and metabolism]; Region: GltB; COG0070 526227004453 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 526227004454 domain_subunit interface; other site 526227004455 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 526227004456 heme-binding site [chemical binding]; other site 526227004457 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526227004458 motif II; other site 526227004459 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14603 526227004460 RuvA N terminal domain; Region: RuvA_N; pfam01330 526227004461 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 526227004462 enoyl-CoA hydratase; Provisional; Region: PRK06688 526227004463 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 526227004464 substrate binding site [chemical binding]; other site 526227004465 oxyanion hole (OAH) forming residues; other site 526227004466 trimer interface [polypeptide binding]; other site 526227004467 DinB superfamily; Region: DinB_2; pfam12867 526227004468 enoyl-CoA hydratase; Provisional; Region: PRK05862 526227004469 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 526227004470 substrate binding site [chemical binding]; other site 526227004471 oxyanion hole (OAH) forming residues; other site 526227004472 trimer interface [polypeptide binding]; other site 526227004473 Cupin domain; Region: Cupin_2; cl09118 526227004474 aspartate kinase; Reviewed; Region: PRK06635 526227004475 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 526227004476 putative nucleotide binding site [chemical binding]; other site 526227004477 putative catalytic residues [active] 526227004478 putative Mg ion binding site [ion binding]; other site 526227004479 putative aspartate binding site [chemical binding]; other site 526227004480 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 526227004481 putative allosteric regulatory site; other site 526227004482 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 526227004483 putative allosteric regulatory residue; other site 526227004484 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 526227004485 active site 526227004486 malate dehydrogenase; Provisional; Region: PRK05442 526227004487 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 526227004488 NAD(P) binding site [chemical binding]; other site 526227004489 dimer interface [polypeptide binding]; other site 526227004490 malate binding site [chemical binding]; other site 526227004491 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 526227004492 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 526227004493 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 526227004494 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 526227004495 B12 binding site [chemical binding]; other site 526227004496 cobalt ligand [ion binding]; other site 526227004497 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 526227004498 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 526227004499 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526227004500 MULE transposase domain; Region: MULE; pfam10551 526227004501 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 526227004502 CoenzymeA binding site [chemical binding]; other site 526227004503 subunit interaction site [polypeptide binding]; other site 526227004504 PHB binding site; other site 526227004505 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 526227004506 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 526227004507 Recombination protein O N terminal; Region: RecO_N; cl15812 526227004508 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 526227004509 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 526227004510 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 526227004511 catalytic residues [active] 526227004512 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 526227004513 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 526227004514 putative active site [active] 526227004515 metal binding site [ion binding]; metal-binding site 526227004516 homodimer binding site [polypeptide binding]; other site 526227004517 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 526227004518 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 526227004519 Dodecin; Region: Dodecin; cl01328 526227004520 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 526227004521 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227004522 CTP synthetase; Validated; Region: pyrG; PRK05380 526227004523 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 526227004524 Catalytic site [active] 526227004525 active site 526227004526 UTP binding site [chemical binding]; other site 526227004527 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 526227004528 active site 526227004529 putative oxyanion hole; other site 526227004530 catalytic triad [active] 526227004531 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227004532 Walker A motif; other site 526227004533 ATP binding site [chemical binding]; other site 526227004534 Walker B motif; other site 526227004535 arginine finger; other site 526227004536 GAF domain; Region: GAF; cl15785 526227004537 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 526227004538 Zn2+ binding site [ion binding]; other site 526227004539 Mg2+ binding site [ion binding]; other site 526227004540 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526227004541 MULE transposase domain; Region: MULE; pfam10551 526227004542 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 526227004543 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227004544 Restriction endonuclease; Region: Mrr_cat; cl00516 526227004545 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 526227004546 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 526227004547 Catalytic site [active] 526227004548 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 526227004549 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 526227004550 arginine decarboxylase, biosynthetic; Region: speA; TIGR01273 526227004551 Helitron helicase-like domain at N-terminus; Region: Helitron_like_N; pfam14214 526227004552 hypothetical protein; Reviewed; Region: PRK00024 526227004553 Protein of unknown function (DUF497); Region: DUF497; cl01108 526227004554 Peptidase family M23; Region: Peptidase_M23; pfam01551 526227004555 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 526227004556 N-acetyl-D-glucosamine binding site [chemical binding]; other site 526227004557 catalytic residue [active] 526227004558 putative transposase OrfB; Reviewed; Region: PHA02517 526227004559 Integrase core domain; Region: rve; cl01316 526227004560 Integrase core domain; Region: rve_3; cl15866 526227004561 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 526227004562 Predicted membrane protein [Function unknown]; Region: COG3748 526227004563 Protein of unknown function (DUF989); Region: DUF989; pfam06181 526227004564 Cytochrome c; Region: Cytochrom_C; cl11414 526227004565 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 526227004566 active site 526227004567 metal binding site [ion binding]; metal-binding site 526227004568 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 526227004569 active site 526227004570 homotetramer interface [polypeptide binding]; other site 526227004571 allantoate amidohydrolase; Reviewed; Region: PRK09290 526227004572 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 526227004573 active site 526227004574 metal binding site [ion binding]; metal-binding site 526227004575 dimer interface [polypeptide binding]; other site 526227004576 allantoinase; Provisional; Region: PRK06189 526227004577 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 526227004578 active site 526227004579 hypothetical protein; Provisional; Region: PRK11171 526227004580 Cupin domain; Region: Cupin_2; cl09118 526227004581 Cupin domain; Region: Cupin_2; cl09118 526227004582 allantoate amidohydrolase; Reviewed; Region: PRK09290 526227004583 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 526227004584 active site 526227004585 metal binding site [ion binding]; metal-binding site 526227004586 dimer interface [polypeptide binding]; other site 526227004587 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 526227004588 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 526227004589 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 526227004590 Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631 526227004591 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 526227004592 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 526227004593 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 526227004594 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 526227004595 XdhC Rossmann domain; Region: XdhC_C; pfam13478 526227004596 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 526227004597 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 526227004598 Walker A/P-loop; other site 526227004599 ATP binding site [chemical binding]; other site 526227004600 Q-loop/lid; other site 526227004601 ABC transporter signature motif; other site 526227004602 Walker B; other site 526227004603 D-loop; other site 526227004604 H-loop/switch region; other site 526227004605 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 526227004606 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 526227004607 TM-ABC transporter signature motif; other site 526227004608 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 526227004609 TM-ABC transporter signature motif; other site 526227004610 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 526227004611 putative ligand binding site [chemical binding]; other site 526227004612 guanine deaminase; Provisional; Region: PRK09228 526227004613 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 526227004614 active site 526227004615 4-aminobutyrate aminotransferase; Provisional; Region: PRK05769 526227004616 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 526227004617 inhibitor-cofactor binding pocket; inhibition site 526227004618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227004619 catalytic residue [active] 526227004620 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 526227004621 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 526227004622 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227004623 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 526227004624 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 526227004625 substrate binding site [chemical binding]; other site 526227004626 oxyanion hole (OAH) forming residues; other site 526227004627 trimer interface [polypeptide binding]; other site 526227004628 Protein of unknown function (DUF433); Region: DUF433; cl01030 526227004629 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 526227004630 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 526227004631 active site 526227004632 catalytic triad [active] 526227004633 oxyanion hole [active] 526227004634 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 526227004635 CoenzymeA binding site [chemical binding]; other site 526227004636 subunit interaction site [polypeptide binding]; other site 526227004637 PHB binding site; other site 526227004638 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 526227004639 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 526227004640 dimer interface [polypeptide binding]; other site 526227004641 active site 526227004642 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 526227004643 ArsC family; Region: ArsC; pfam03960 526227004644 catalytic residue [active] 526227004645 putative transposase OrfB; Reviewed; Region: PHA02517 526227004646 Integrase core domain; Region: rve; cl01316 526227004647 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 526227004648 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 526227004649 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526227004650 active site 526227004651 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 526227004652 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526227004653 metal binding site [ion binding]; metal-binding site 526227004654 active site 526227004655 I-site; other site 526227004656 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227004657 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 526227004658 Adenosine specific kinase; Region: Adenosine_kin; cl00796 526227004659 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 526227004660 catalytic triad [active] 526227004661 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 526227004662 tetramer (dimer of dimers) interface [polypeptide binding]; other site 526227004663 active site 526227004664 dimer interface [polypeptide binding]; other site 526227004665 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 526227004666 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 526227004667 active site 526227004668 HIGH motif; other site 526227004669 KMSKS motif; other site 526227004670 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 526227004671 tRNA binding surface [nucleotide binding]; other site 526227004672 anticodon binding site; other site 526227004673 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 526227004674 dimer interface [polypeptide binding]; other site 526227004675 putative tRNA-binding site [nucleotide binding]; other site 526227004676 putative transposase OrfB; Reviewed; Region: PHA02517 526227004677 Integrase core domain; Region: rve; cl01316 526227004678 Integrase core domain; Region: rve_3; cl15866 526227004679 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 526227004680 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 526227004681 calcium binding site 2 [ion binding]; other site 526227004682 active site 526227004683 catalytic triad [active] 526227004684 calcium binding site 1 [ion binding]; other site 526227004685 Helix-turn-helix domains; Region: HTH; cl00088 526227004686 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 526227004687 SpoVR like protein; Region: SpoVR; pfam04293 526227004688 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 526227004689 metal ion-dependent adhesion site (MIDAS); other site 526227004690 PrkA AAA domain; Region: AAA_PrkA; smart00763 526227004691 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 526227004692 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 526227004693 homotrimer interaction site [polypeptide binding]; other site 526227004694 active site 526227004695 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 526227004696 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 526227004697 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 526227004698 dimer interface [polypeptide binding]; other site 526227004699 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 526227004700 active site 526227004701 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 526227004702 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 526227004703 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 526227004704 active site 526227004705 octamer interface [polypeptide binding]; other site 526227004706 LamB/YcsF family; Region: LamB_YcsF; cl00664 526227004707 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 526227004708 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 526227004709 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 526227004710 seryl-tRNA synthetase; Provisional; Region: PRK05431 526227004711 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 526227004712 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 526227004713 dimer interface [polypeptide binding]; other site 526227004714 active site 526227004715 motif 1; other site 526227004716 motif 2; other site 526227004717 motif 3; other site 526227004718 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 526227004719 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 526227004720 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 526227004721 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526227004722 catalytic residue [active] 526227004723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 526227004724 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 526227004725 NodB motif; other site 526227004726 putative active site [active] 526227004727 putative catalytic site [active] 526227004728 putative Zn binding site [ion binding]; other site 526227004729 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 526227004730 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 526227004731 active site 526227004732 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 526227004733 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526227004734 putative ADP-binding pocket [chemical binding]; other site 526227004735 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 526227004736 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 526227004737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227004738 catalytic residue [active] 526227004739 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 526227004740 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 526227004741 substrate binding site [chemical binding]; other site 526227004742 active site 526227004743 catalytic residues [active] 526227004744 heterodimer interface [polypeptide binding]; other site 526227004745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 526227004746 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 526227004747 Response regulator receiver domain; Region: Response_reg; pfam00072 526227004748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227004749 active site 526227004750 phosphorylation site [posttranslational modification] 526227004751 intermolecular recognition site; other site 526227004752 dimerization interface [polypeptide binding]; other site 526227004753 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 526227004754 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 526227004755 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 526227004756 dimer interface [polypeptide binding]; other site 526227004757 putative CheW interface [polypeptide binding]; other site 526227004758 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 526227004759 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 526227004760 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 526227004761 dimer interface [polypeptide binding]; other site 526227004762 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 526227004763 putative CheW interface [polypeptide binding]; other site 526227004764 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 526227004765 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 526227004766 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 526227004767 putative binding surface; other site 526227004768 active site 526227004769 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 526227004770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227004771 ATP binding site [chemical binding]; other site 526227004772 Mg2+ binding site [ion binding]; other site 526227004773 G-X-G motif; other site 526227004774 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 526227004775 Response regulator receiver domain; Region: Response_reg; pfam00072 526227004776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227004777 active site 526227004778 phosphorylation site [posttranslational modification] 526227004779 intermolecular recognition site; other site 526227004780 dimerization interface [polypeptide binding]; other site 526227004781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 526227004782 phosphorylation site [posttranslational modification] 526227004783 intermolecular recognition site; other site 526227004784 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 526227004785 Response regulator receiver domain; Region: Response_reg; pfam00072 526227004786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227004787 active site 526227004788 phosphorylation site [posttranslational modification] 526227004789 intermolecular recognition site; other site 526227004790 dimerization interface [polypeptide binding]; other site 526227004791 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 526227004792 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 526227004793 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 526227004794 substrate binding site [chemical binding]; other site 526227004795 dimer interface [polypeptide binding]; other site 526227004796 NADP binding site [chemical binding]; other site 526227004797 catalytic residues [active] 526227004798 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 526227004799 substrate binding site [chemical binding]; other site 526227004800 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 526227004801 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 526227004802 alpha subunit interface [polypeptide binding]; other site 526227004803 TPP binding site [chemical binding]; other site 526227004804 heterodimer interface [polypeptide binding]; other site 526227004805 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 526227004806 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 526227004807 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 526227004808 TPP-binding site [chemical binding]; other site 526227004809 tetramer interface [polypeptide binding]; other site 526227004810 heterodimer interface [polypeptide binding]; other site 526227004811 phosphorylation loop region [posttranslational modification] 526227004812 putative transposase OrfB; Reviewed; Region: PHA02517 526227004813 Integrase core domain; Region: rve; cl01316 526227004814 Integrase core domain; Region: rve_3; cl15866 526227004815 trigger factor; Region: tig; TIGR00115 526227004816 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 526227004817 Clp protease; Region: CLP_protease; pfam00574 526227004818 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 526227004819 oligomer interface [polypeptide binding]; other site 526227004820 active site residues [active] 526227004821 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 526227004822 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 526227004823 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227004824 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227004825 Walker A motif; other site 526227004826 ATP binding site [chemical binding]; other site 526227004827 Walker B motif; other site 526227004828 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 526227004829 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 526227004830 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 526227004831 spermidine synthase; Provisional; Region: PRK00811 526227004832 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227004833 S-adenosylmethionine binding site [chemical binding]; other site 526227004834 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 526227004835 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227004836 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 526227004837 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 526227004838 Occludin homology domain; Region: Occludin_ELL; pfam07303 526227004839 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 526227004840 Protein of unknown function, DUF606; Region: DUF606; cl01273 526227004841 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 526227004842 allantoate amidohydrolase; Reviewed; Region: PRK09290 526227004843 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 526227004844 active site 526227004845 metal binding site [ion binding]; metal-binding site 526227004846 dimer interface [polypeptide binding]; other site 526227004847 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 526227004848 Helix-turn-helix domains; Region: HTH; cl00088 526227004849 hypothetical protein; Provisional; Region: PRK06062 526227004850 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 526227004851 inhibitor-cofactor binding pocket; inhibition site 526227004852 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227004853 catalytic residue [active] 526227004854 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 526227004855 octamerization interface [polypeptide binding]; other site 526227004856 diferric-oxygen binding site [ion binding]; other site 526227004857 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 526227004858 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 526227004859 tetrameric interface [polypeptide binding]; other site 526227004860 NAD binding site [chemical binding]; other site 526227004861 catalytic residues [active] 526227004862 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 526227004863 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 526227004864 active site clefts [active] 526227004865 zinc binding site [ion binding]; other site 526227004866 dimer interface [polypeptide binding]; other site 526227004867 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 526227004868 quinone interaction residues [chemical binding]; other site 526227004869 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 526227004870 active site 526227004871 catalytic residues [active] 526227004872 FMN binding site [chemical binding]; other site 526227004873 substrate binding site [chemical binding]; other site 526227004874 dihydroorotase; Validated; Region: pyrC; PRK09357 526227004875 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 526227004876 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 526227004877 active site 526227004878 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 526227004879 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 526227004880 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227004881 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 526227004882 active site 526227004883 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 526227004884 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 526227004885 active site 526227004886 metal binding site [ion binding]; metal-binding site 526227004887 DNA binding site [nucleotide binding] 526227004888 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 526227004889 Walker A/P-loop; other site 526227004890 ATP binding site [chemical binding]; other site 526227004891 Q-loop/lid; other site 526227004892 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 526227004893 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227004894 Walker B; other site 526227004895 D-loop; other site 526227004896 H-loop/switch region; other site 526227004897 integral membrane protein MviN; Region: mviN; TIGR01695 526227004898 MatE; Region: MatE; cl10513 526227004899 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 526227004900 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 526227004901 Dimer interface [polypeptide binding]; other site 526227004902 anticodon binding site; other site 526227004903 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 526227004904 motif 1; other site 526227004905 dimer interface [polypeptide binding]; other site 526227004906 active site 526227004907 motif 2; other site 526227004908 motif 3; other site 526227004909 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 526227004910 active site 526227004911 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 526227004912 Phospholipid methyltransferase; Region: PEMT; cl00763 526227004913 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 526227004914 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 526227004915 malonyl-CoA binding site [chemical binding]; other site 526227004916 dimer interface [polypeptide binding]; other site 526227004917 active site 526227004918 product binding site; other site 526227004919 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 526227004920 FMN binding site [chemical binding]; other site 526227004921 dimer interface [polypeptide binding]; other site 526227004922 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526227004923 MULE transposase domain; Region: MULE; pfam10551 526227004924 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 526227004925 non-specific DNA binding site [nucleotide binding]; other site 526227004926 salt bridge; other site 526227004927 sequence-specific DNA binding site [nucleotide binding]; other site 526227004928 Predicted transcriptional regulator [Transcription]; Region: COG2932 526227004929 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 526227004930 Catalytic site [active] 526227004931 Integrase core domain; Region: rve; cl01316 526227004932 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227004933 AAA domain; Region: AAA_22; pfam13401 526227004934 Helix-turn-helix domains; Region: HTH; cl00088 526227004935 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 526227004936 Terminase-like family; Region: Terminase_6; pfam03237 526227004937 Protein of unknown function (DUF935); Region: DUF935; pfam06074 526227004938 Mu-like prophage protein gp29 [Function unknown]; Region: COG4383 526227004939 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 526227004940 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 526227004941 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 526227004942 Probable transposase; Region: OrfB_IS605; pfam01385 526227004943 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 526227004944 Transposase IS200 like; Region: Y1_Tnp; cl00848 526227004945 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 526227004946 Baseplate J-like protein; Region: Baseplate_J; cl01294 526227004947 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227004948 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227004949 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 526227004950 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 526227004951 active site 526227004952 substrate binding site [chemical binding]; other site 526227004953 metal binding site [ion binding]; metal-binding site 526227004954 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 526227004955 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227004956 Family description; Region: UvrD_C_2; cl15862 526227004957 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 526227004958 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 526227004959 23S rRNA interface [nucleotide binding]; other site 526227004960 L3 interface [polypeptide binding]; other site 526227004961 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 526227004962 aromatic arch; other site 526227004963 DCoH dimer interaction site [polypeptide binding]; other site 526227004964 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 526227004965 DCoH tetramer interaction site [polypeptide binding]; other site 526227004966 substrate binding site [chemical binding]; other site 526227004967 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 526227004968 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 526227004969 TPP-binding site [chemical binding]; other site 526227004970 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 526227004971 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 526227004972 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 526227004973 E3 interaction surface; other site 526227004974 lipoyl attachment site [posttranslational modification]; other site 526227004975 e3 binding domain; Region: E3_binding; pfam02817 526227004976 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 526227004977 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 526227004978 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227004979 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 526227004980 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 526227004981 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 526227004982 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 526227004983 active site 526227004984 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 526227004985 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 526227004986 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 526227004987 substrate binding pocket [chemical binding]; other site 526227004988 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 526227004989 B12 binding site [chemical binding]; other site 526227004990 cobalt ligand [ion binding]; other site 526227004991 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 526227004992 hypothetical protein; Provisional; Region: PRK08609 526227004993 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 526227004994 active site 526227004995 primer binding site [nucleotide binding]; other site 526227004996 NTP binding site [chemical binding]; other site 526227004997 metal binding triad [ion binding]; metal-binding site 526227004998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227004999 S-adenosylmethionine binding site [chemical binding]; other site 526227005000 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 526227005001 Predicted acetyltransferase [General function prediction only]; Region: COG3153 526227005002 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526227005003 Coenzyme A binding pocket [chemical binding]; other site 526227005004 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 526227005005 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 526227005006 PhoU domain; Region: PhoU; pfam01895 526227005007 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 526227005008 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 526227005009 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227005010 Walker A/P-loop; other site 526227005011 ATP binding site [chemical binding]; other site 526227005012 Q-loop/lid; other site 526227005013 ABC transporter signature motif; other site 526227005014 Walker B; other site 526227005015 D-loop; other site 526227005016 H-loop/switch region; other site 526227005017 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 526227005018 ABC-2 type transporter; Region: ABC2_membrane; cl11417 526227005019 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 526227005020 NatA is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled proton or K+ uptake. NatB possess six putative membrane spanning regions at its...; Region: ABC_NatA_sodium_exporter; cd03266 526227005021 Walker A/P-loop; other site 526227005022 ATP binding site [chemical binding]; other site 526227005023 Q-loop/lid; other site 526227005024 ABC transporter signature motif; other site 526227005025 Walker B; other site 526227005026 D-loop; other site 526227005027 H-loop/switch region; other site 526227005028 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 526227005029 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 526227005030 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526227005031 active site 526227005032 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 526227005033 active site 526227005034 RIP metalloprotease RseP; Region: TIGR00054 526227005035 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 526227005036 protein binding site [polypeptide binding]; other site 526227005037 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 526227005038 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 526227005039 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 526227005040 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 526227005041 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 526227005042 ribosome recycling factor; Reviewed; Region: frr; PRK00083 526227005043 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 526227005044 hinge region; other site 526227005045 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 526227005046 putative nucleotide binding site [chemical binding]; other site 526227005047 uridine monophosphate binding site [chemical binding]; other site 526227005048 homohexameric interface [polypeptide binding]; other site 526227005049 elongation factor Ts; Reviewed; Region: tsf; PRK12332 526227005050 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 526227005051 Elongation factor TS; Region: EF_TS; pfam00889 526227005052 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 526227005053 rRNA interaction site [nucleotide binding]; other site 526227005054 S8 interaction site; other site 526227005055 putative laminin-1 binding site; other site 526227005056 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227005057 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 526227005058 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 526227005059 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 526227005060 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227005061 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 526227005062 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 526227005063 active site 526227005064 catalytic site [active] 526227005065 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 526227005066 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526227005067 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 526227005068 conserved hypothetical protein; Region: TIGR03492 526227005069 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 526227005070 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 526227005071 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 526227005072 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 526227005073 DEAD-like helicases superfamily; Region: DEXDc; smart00487 526227005074 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526227005075 ATP binding site [chemical binding]; other site 526227005076 putative Mg++ binding site [ion binding]; other site 526227005077 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526227005078 nucleotide binding region [chemical binding]; other site 526227005079 ATP-binding site [chemical binding]; other site 526227005080 TRCF domain; Region: TRCF; cl04088 526227005081 DDE superfamily endonuclease; Region: DDE_4; cl15789 526227005082 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227005083 putative transposase OrfB; Reviewed; Region: PHA02517 526227005084 Integrase core domain; Region: rve; cl01316 526227005085 Integrase core domain; Region: rve_3; cl15866 526227005086 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 526227005087 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 526227005088 Cytochrome c552; Region: Cytochrom_C552; pfam02335 526227005089 Acetokinase family; Region: Acetate_kinase; cl01029 526227005090 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 526227005091 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 526227005092 active site 526227005093 catalytic triad [active] 526227005094 dimer interface [polypeptide binding]; other site 526227005095 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 526227005096 PPIC-type PPIASE domain; Region: Rotamase; cl08278 526227005097 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 526227005098 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 526227005099 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 526227005100 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 526227005101 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 526227005102 homodimer interface [polypeptide binding]; other site 526227005103 substrate-cofactor binding pocket; other site 526227005104 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227005105 catalytic residue [active] 526227005106 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227005107 putative transposase OrfB; Reviewed; Region: PHA02517 526227005108 Integrase core domain; Region: rve; cl01316 526227005109 Integrase core domain; Region: rve_3; cl15866 526227005110 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227005111 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 526227005112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227005113 dimer interface [polypeptide binding]; other site 526227005114 conserved gate region; other site 526227005115 putative PBP binding loops; other site 526227005116 ABC-ATPase subunit interface; other site 526227005117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227005118 dimer interface [polypeptide binding]; other site 526227005119 conserved gate region; other site 526227005120 putative PBP binding loops; other site 526227005121 ABC-ATPase subunit interface; other site 526227005122 ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432 526227005123 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227005124 Walker A/P-loop; other site 526227005125 ATP binding site [chemical binding]; other site 526227005126 Q-loop/lid; other site 526227005127 ABC transporter signature motif; other site 526227005128 Walker B; other site 526227005129 D-loop; other site 526227005130 H-loop/switch region; other site 526227005131 TOBE domain; Region: TOBE_2; cl01440 526227005132 Membrane transport protein; Region: Mem_trans; cl09117 526227005133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 526227005134 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 526227005135 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 526227005136 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227005137 S-adenosylmethionine binding site [chemical binding]; other site 526227005138 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 526227005139 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 526227005140 intersubunit interface [polypeptide binding]; other site 526227005141 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 526227005142 metal binding site 2 [ion binding]; metal-binding site 526227005143 putative DNA binding helix; other site 526227005144 metal binding site 1 [ion binding]; metal-binding site 526227005145 dimer interface [polypeptide binding]; other site 526227005146 structural Zn2+ binding site [ion binding]; other site 526227005147 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 526227005148 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 526227005149 substrate binding site [chemical binding]; other site 526227005150 ATP binding site [chemical binding]; other site 526227005151 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 526227005152 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 526227005153 tetramer interface [polypeptide binding]; other site 526227005154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227005155 catalytic residue [active] 526227005156 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 526227005157 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 526227005158 tetramer interface [polypeptide binding]; other site 526227005159 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227005160 catalytic residue [active] 526227005161 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 526227005162 lipoyl attachment site [posttranslational modification]; other site 526227005163 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 526227005164 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 526227005165 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 526227005166 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 526227005167 G1 box; other site 526227005168 GTP/Mg2+ binding site [chemical binding]; other site 526227005169 G2 box; other site 526227005170 Switch I region; other site 526227005171 G3 box; other site 526227005172 Switch II region; other site 526227005173 G4 box; other site 526227005174 G5 box; other site 526227005175 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 526227005176 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 526227005177 hypothetical protein; Provisional; Region: PRK06446 526227005178 metal binding site [ion binding]; metal-binding site 526227005179 dimer interface [polypeptide binding]; other site 526227005180 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 526227005181 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 526227005182 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 526227005183 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 526227005184 FeS/SAM binding site; other site 526227005185 HemN C-terminal domain; Region: HemN_C; pfam06969 526227005186 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526227005187 MULE transposase domain; Region: MULE; pfam10551 526227005188 trehalose synthase; Region: treS_nterm; TIGR02456 526227005189 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 526227005190 active site 526227005191 catalytic site [active] 526227005192 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 526227005193 catalytic residues [active] 526227005194 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 526227005195 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 526227005196 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 526227005197 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 526227005198 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 526227005199 RNase E interface [polypeptide binding]; other site 526227005200 trimer interface [polypeptide binding]; other site 526227005201 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 526227005202 RNase E interface [polypeptide binding]; other site 526227005203 trimer interface [polypeptide binding]; other site 526227005204 active site 526227005205 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 526227005206 putative nucleic acid binding region [nucleotide binding]; other site 526227005207 G-X-X-G motif; other site 526227005208 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 526227005209 RNA binding site [nucleotide binding]; other site 526227005210 domain interface; other site 526227005211 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 526227005212 16S/18S rRNA binding site [nucleotide binding]; other site 526227005213 S13e-L30e interaction site [polypeptide binding]; other site 526227005214 25S rRNA binding site [nucleotide binding]; other site 526227005215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227005216 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526227005217 putative substrate translocation pore; other site 526227005218 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 526227005219 Low-spin heme binding site [chemical binding]; other site 526227005220 D-pathway; other site 526227005221 Putative water exit pathway; other site 526227005222 Binuclear center (active site) [active] 526227005223 K-pathway; other site 526227005224 Putative proton exit pathway; other site 526227005225 Cytochrome C oxidase subunit II, transmembrane; Region: COX2-transmemb; pfam09125 526227005226 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 526227005227 Cytochrome c oxidase subunit IIa family; Region: CoxIIa; pfam08113 526227005228 transketolase; Reviewed; Region: PRK05899 526227005229 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 526227005230 TPP-binding site [chemical binding]; other site 526227005231 dimer interface [polypeptide binding]; other site 526227005232 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 526227005233 PYR/PP interface [polypeptide binding]; other site 526227005234 dimer interface [polypeptide binding]; other site 526227005235 TPP binding site [chemical binding]; other site 526227005236 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 526227005237 elongation factor P; Validated; Region: PRK00529 526227005238 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 526227005239 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 526227005240 RNA binding site [nucleotide binding]; other site 526227005241 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 526227005242 RNA binding site [nucleotide binding]; other site 526227005243 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 526227005244 carboxyltransferase (CT) interaction site; other site 526227005245 biotinylation site [posttranslational modification]; other site 526227005246 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 526227005247 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 526227005248 ATP-grasp domain; Region: ATP-grasp_4; cl03087 526227005249 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 526227005250 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 526227005251 ADP-ribose binding site [chemical binding]; other site 526227005252 dimer interface [polypeptide binding]; other site 526227005253 active site 526227005254 nudix motif; other site 526227005255 metal binding site [ion binding]; metal-binding site 526227005256 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 526227005257 DHH family; Region: DHH; pfam01368 526227005258 FOG: CBS domain [General function prediction only]; Region: COG0517 526227005259 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 526227005260 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 526227005261 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 526227005262 active site 526227005263 NTP binding site [chemical binding]; other site 526227005264 metal binding triad [ion binding]; metal-binding site 526227005265 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 526227005266 active site 526227005267 putative substrate binding region [chemical binding]; other site 526227005268 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 526227005269 active site 526227005270 putative substrate binding region [chemical binding]; other site 526227005271 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 526227005272 endonuclease IV; Provisional; Region: PRK01060 526227005273 AP (apurinic/apyrimidinic) site pocket; other site 526227005274 DNA interaction; other site 526227005275 Metal-binding active site; metal-binding site 526227005276 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 526227005277 putative peptidoglycan binding site; other site 526227005278 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 526227005279 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 526227005280 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 526227005281 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 526227005282 active site 526227005283 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 526227005284 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 526227005285 active site 526227005286 HIGH motif; other site 526227005287 nucleotide binding site [chemical binding]; other site 526227005288 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 526227005289 active site 526227005290 KMSKS motif; other site 526227005291 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 526227005292 tRNA binding surface [nucleotide binding]; other site 526227005293 anticodon binding site; other site 526227005294 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 526227005295 active site 526227005296 intersubunit interactions; other site 526227005297 catalytic residue [active] 526227005298 transcription termination factor Rho; Provisional; Region: rho; PRK09376 526227005299 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 526227005300 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 526227005301 RNA binding site [nucleotide binding]; other site 526227005302 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227005303 Walker A motif; other site 526227005304 ATP binding site [chemical binding]; other site 526227005305 Walker B motif; other site 526227005306 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 526227005307 putative peptidoglycan binding site; other site 526227005308 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 526227005309 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 526227005310 putative peptidoglycan binding site; other site 526227005311 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 526227005312 putative peptidoglycan binding site; other site 526227005313 Peptidase family M23; Region: Peptidase_M23; pfam01551 526227005314 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 526227005315 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 526227005316 active site 526227005317 multimer interface [polypeptide binding]; other site 526227005318 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 526227005319 predicted active site [active] 526227005320 catalytic triad [active] 526227005321 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 526227005322 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 526227005323 putative dimer interface [polypeptide binding]; other site 526227005324 putative anticodon binding site; other site 526227005325 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 526227005326 homodimer interface [polypeptide binding]; other site 526227005327 motif 1; other site 526227005328 motif 2; other site 526227005329 active site 526227005330 motif 3; other site 526227005331 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 526227005332 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 526227005333 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 526227005334 active site 526227005335 motif I; other site 526227005336 motif II; other site 526227005337 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 526227005338 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 526227005339 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 526227005340 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 526227005341 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 526227005342 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 526227005343 dimer interface [polypeptide binding]; other site 526227005344 anticodon binding site; other site 526227005345 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 526227005346 homodimer interface [polypeptide binding]; other site 526227005347 motif 1; other site 526227005348 active site 526227005349 motif 2; other site 526227005350 GAD domain; Region: GAD; pfam02938 526227005351 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 526227005352 motif 3; other site 526227005353 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 526227005354 SmpB-tmRNA interface; other site 526227005355 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 526227005356 active site 526227005357 metal binding site [ion binding]; metal-binding site 526227005358 Sporulation and spore germination; Region: Germane; cl11253 526227005359 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 526227005360 Walker A/P-loop; other site 526227005361 ATP binding site [chemical binding]; other site 526227005362 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 526227005363 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 526227005364 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 526227005365 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 526227005366 ABC transporter signature motif; other site 526227005367 Walker B; other site 526227005368 D-loop; other site 526227005369 H-loop/switch region; other site 526227005370 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 526227005371 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 526227005372 active site 526227005373 DNA binding site [nucleotide binding] 526227005374 Int/Topo IB signature motif; other site 526227005375 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 526227005376 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 526227005377 dimer interface [polypeptide binding]; other site 526227005378 motif 1; other site 526227005379 active site 526227005380 motif 2; other site 526227005381 motif 3; other site 526227005382 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 526227005383 anticodon binding site; other site 526227005384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227005385 dimer interface [polypeptide binding]; other site 526227005386 conserved gate region; other site 526227005387 putative PBP binding loops; other site 526227005388 ABC-ATPase subunit interface; other site 526227005389 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 526227005390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227005391 dimer interface [polypeptide binding]; other site 526227005392 conserved gate region; other site 526227005393 putative PBP binding loops; other site 526227005394 ABC-ATPase subunit interface; other site 526227005395 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 526227005396 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227005397 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227005398 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 526227005399 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 526227005400 Phosphoglycerate kinase; Region: PGK; pfam00162 526227005401 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 526227005402 substrate binding site [chemical binding]; other site 526227005403 hinge regions; other site 526227005404 ADP binding site [chemical binding]; other site 526227005405 catalytic site [active] 526227005406 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 526227005407 substrate binding site [chemical binding]; other site 526227005408 dimer interface [polypeptide binding]; other site 526227005409 catalytic triad [active] 526227005410 hypothetical protein; Provisional; Region: PRK08912 526227005411 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 526227005412 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227005413 homodimer interface [polypeptide binding]; other site 526227005414 catalytic residue [active] 526227005415 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 526227005416 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 526227005417 putative dimer interface [polypeptide binding]; other site 526227005418 putative transposase OrfB; Reviewed; Region: PHA02517 526227005419 Integrase core domain; Region: rve; cl01316 526227005420 Integrase core domain; Region: rve_3; cl15866 526227005421 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526227005422 Helix-turn-helix domains; Region: HTH; cl00088 526227005423 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 526227005424 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 526227005425 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 526227005426 active site 526227005427 Zn binding site [ion binding]; other site 526227005428 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526227005429 Helix-turn-helix domains; Region: HTH; cl00088 526227005430 HD supefamily hydrolase [General function prediction only]; Region: COG3294 526227005431 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 526227005432 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 526227005433 substrate binding site [chemical binding]; other site 526227005434 oxyanion hole (OAH) forming residues; other site 526227005435 trimer interface [polypeptide binding]; other site 526227005436 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 526227005437 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 526227005438 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 526227005439 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 526227005440 Walker A/P-loop; other site 526227005441 ATP binding site [chemical binding]; other site 526227005442 Q-loop/lid; other site 526227005443 ABC transporter signature motif; other site 526227005444 Walker B; other site 526227005445 D-loop; other site 526227005446 H-loop/switch region; other site 526227005447 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 526227005448 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 526227005449 ligand binding site [chemical binding]; other site 526227005450 flexible hinge region; other site 526227005451 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 526227005452 putative switch regulator; other site 526227005453 non-specific DNA interactions [nucleotide binding]; other site 526227005454 DNA binding site [nucleotide binding] 526227005455 sequence specific DNA binding site [nucleotide binding]; other site 526227005456 putative cAMP binding site [chemical binding]; other site 526227005457 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 526227005458 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 526227005459 substrate binding site [chemical binding]; other site 526227005460 hexamer interface [polypeptide binding]; other site 526227005461 metal binding site [ion binding]; metal-binding site 526227005462 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 526227005463 hypothetical protein; Provisional; Region: PRK08201 526227005464 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 526227005465 metal binding site [ion binding]; metal-binding site 526227005466 putative dimer interface [polypeptide binding]; other site 526227005467 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 526227005468 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 526227005469 DNA binding residues [nucleotide binding] 526227005470 putative dimer interface [polypeptide binding]; other site 526227005471 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 526227005472 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 526227005473 DNA binding residues [nucleotide binding] 526227005474 putative dimer interface [polypeptide binding]; other site 526227005475 malate dehydrogenase; Provisional; Region: PRK13529 526227005476 Malic enzyme, N-terminal domain; Region: malic; pfam00390 526227005477 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 526227005478 NAD(P) binding site [chemical binding]; other site 526227005479 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 526227005480 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 526227005481 NAD(P) binding site [chemical binding]; other site 526227005482 catalytic residues [active] 526227005483 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 526227005484 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 526227005485 active site 526227005486 (T/H)XGH motif; other site 526227005487 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227005488 S-adenosylmethionine binding site [chemical binding]; other site 526227005489 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 526227005490 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227005491 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 526227005492 YibE/F-like protein; Region: YibE_F; cl02259 526227005493 G8 domain; Region: G8; pfam10162 526227005494 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 526227005495 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 526227005496 nucleotide binding pocket [chemical binding]; other site 526227005497 K-X-D-G motif; other site 526227005498 catalytic site [active] 526227005499 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 526227005500 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 526227005501 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 526227005502 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227005503 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227005504 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 526227005505 ligand binding site [chemical binding]; other site 526227005506 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 526227005507 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 526227005508 Walker A/P-loop; other site 526227005509 ATP binding site [chemical binding]; other site 526227005510 Q-loop/lid; other site 526227005511 ABC transporter signature motif; other site 526227005512 Walker B; other site 526227005513 D-loop; other site 526227005514 H-loop/switch region; other site 526227005515 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 526227005516 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 526227005517 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 526227005518 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 526227005519 Prephenate dehydratase; Region: PDT; pfam00800 526227005520 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 526227005521 putative L-Phe binding site [chemical binding]; other site 526227005522 Response regulator receiver domain; Region: Response_reg; pfam00072 526227005523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227005524 active site 526227005525 phosphorylation site [posttranslational modification] 526227005526 intermolecular recognition site; other site 526227005527 dimerization interface [polypeptide binding]; other site 526227005528 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 526227005529 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 526227005530 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 526227005531 OstA-like protein; Region: OstA; cl00844 526227005532 OstA-like protein; Region: OstA; cl00844 526227005533 OstA-like protein; Region: OstA; cl00844 526227005534 FOG: CBS domain [General function prediction only]; Region: COG0517 526227005535 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 526227005536 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 526227005537 NMT1/THI5 like; Region: NMT1; pfam09084 526227005538 NMT1-like family; Region: NMT1_2; cl15260 526227005539 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 526227005540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 526227005541 NMT1/THI5 like; Region: NMT1; pfam09084 526227005542 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 526227005543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 526227005544 cytosine deaminase; Provisional; Region: PRK09230 526227005545 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 526227005546 active site 526227005547 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 526227005548 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 526227005549 Walker A/P-loop; other site 526227005550 ATP binding site [chemical binding]; other site 526227005551 Q-loop/lid; other site 526227005552 ABC transporter signature motif; other site 526227005553 Walker B; other site 526227005554 D-loop; other site 526227005555 H-loop/switch region; other site 526227005556 LysE type translocator; Region: LysE; cl00565 526227005557 phenylhydantoinase; Validated; Region: PRK08323 526227005558 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 526227005559 tetramer interface [polypeptide binding]; other site 526227005560 active site 526227005561 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 526227005562 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 526227005563 homodimer interface [polypeptide binding]; other site 526227005564 active site 526227005565 FMN binding site [chemical binding]; other site 526227005566 substrate binding site [chemical binding]; other site 526227005567 4Fe-4S binding domain; Region: Fer4; cl02805 526227005568 4Fe-4S binding domain; Region: Fer4; cl02805 526227005569 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 526227005570 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 526227005571 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227005572 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 526227005573 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 526227005574 Found in ATP-dependent protease La (LON); Region: LON; smart00464 526227005575 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227005576 Walker A motif; other site 526227005577 ATP binding site [chemical binding]; other site 526227005578 Walker B motif; other site 526227005579 arginine finger; other site 526227005580 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 526227005581 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14334 526227005582 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 526227005583 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 526227005584 FeS/SAM binding site; other site 526227005585 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 526227005586 active site 526227005587 substrate binding site [chemical binding]; other site 526227005588 ATP binding site [chemical binding]; other site 526227005589 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 526227005590 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 526227005591 putative homodimer interface [polypeptide binding]; other site 526227005592 putative active site pocket [active] 526227005593 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 526227005594 Flagellin N-methylase; Region: FliB; cl00497 526227005595 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 526227005596 MPN+ (JAMM) motif; other site 526227005597 Zinc-binding site [ion binding]; other site 526227005598 Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374 526227005599 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 526227005600 elongation factor G; Reviewed; Region: PRK12740 526227005601 G1 box; other site 526227005602 putative GEF interaction site [polypeptide binding]; other site 526227005603 GTP/Mg2+ binding site [chemical binding]; other site 526227005604 Switch I region; other site 526227005605 G2 box; other site 526227005606 G3 box; other site 526227005607 Switch II region; other site 526227005608 G4 box; other site 526227005609 G5 box; other site 526227005610 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 526227005611 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 526227005612 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 526227005613 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 526227005614 Protein of unknown function (DUF1999); Region: DUF1999; pfam09390 526227005615 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227005616 aconitate hydratase; Validated; Region: PRK09277 526227005617 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 526227005618 substrate binding site [chemical binding]; other site 526227005619 ligand binding site [chemical binding]; other site 526227005620 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 526227005621 substrate binding site [chemical binding]; other site 526227005622 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526227005623 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 526227005624 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 526227005625 molybdopterin cofactor binding site; other site 526227005626 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 526227005627 molybdopterin cofactor binding site; other site 526227005628 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 526227005629 Protein of unknown function (DUF503); Region: DUF503; cl00669 526227005630 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 526227005631 FAD binding domain; Region: FAD_binding_4; pfam01565 526227005632 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 526227005633 EVE domain; Region: EVE; cl00728 526227005634 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 526227005635 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 526227005636 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 526227005637 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 526227005638 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 526227005639 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 526227005640 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 526227005641 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 526227005642 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 526227005643 active site 526227005644 catalytic residues [active] 526227005645 metal binding site [ion binding]; metal-binding site 526227005646 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 526227005647 2-isopropylmalate synthase; Validated; Region: PRK00915 526227005648 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 526227005649 active site 526227005650 catalytic residues [active] 526227005651 metal binding site [ion binding]; metal-binding site 526227005652 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 526227005653 ketol-acid reductoisomerase; Provisional; Region: PRK05479 526227005654 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227005655 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 526227005656 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 526227005657 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 526227005658 putative valine binding site [chemical binding]; other site 526227005659 dimer interface [polypeptide binding]; other site 526227005660 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 526227005661 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 526227005662 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 526227005663 PYR/PP interface [polypeptide binding]; other site 526227005664 dimer interface [polypeptide binding]; other site 526227005665 TPP binding site [chemical binding]; other site 526227005666 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 526227005667 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 526227005668 TPP-binding site [chemical binding]; other site 526227005669 dimer interface [polypeptide binding]; other site 526227005670 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 526227005671 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 526227005672 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 526227005673 Integral membrane protein TerC family; Region: TerC; cl10468 526227005674 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 526227005675 Helix-turn-helix domains; Region: HTH; cl00088 526227005676 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227005677 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526227005678 putative substrate translocation pore; other site 526227005679 fumarate hydratase; Reviewed; Region: fumC; PRK00485 526227005680 Class II fumarases; Region: Fumarase_classII; cd01362 526227005681 active site 526227005682 tetramer interface [polypeptide binding]; other site 526227005683 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 526227005684 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 526227005685 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 526227005686 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 526227005687 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 526227005688 Predicted ATPase [General function prediction only]; Region: COG3899 526227005689 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227005690 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227005691 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 526227005692 active site 526227005693 ribulose/triose binding site [chemical binding]; other site 526227005694 phosphate binding site [ion binding]; other site 526227005695 substrate (anthranilate) binding pocket [chemical binding]; other site 526227005696 product (indole) binding pocket [chemical binding]; other site 526227005697 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 526227005698 active site 526227005699 nucleophile elbow; other site 526227005700 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 526227005701 NMT1-like family; Region: NMT1_2; cl15260 526227005702 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 526227005703 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227005704 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227005705 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 526227005706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227005707 S-adenosylmethionine binding site [chemical binding]; other site 526227005708 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 526227005709 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 526227005710 substrate binding site [chemical binding]; other site 526227005711 glutamase interaction surface [polypeptide binding]; other site 526227005712 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 526227005713 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 526227005714 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 526227005715 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 526227005716 putative active site [active] 526227005717 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 526227005718 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 526227005719 Walker A/P-loop; other site 526227005720 ATP binding site [chemical binding]; other site 526227005721 Q-loop/lid; other site 526227005722 ABC transporter signature motif; other site 526227005723 Walker B; other site 526227005724 D-loop; other site 526227005725 H-loop/switch region; other site 526227005726 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 526227005727 ABC-ATPase subunit interface; other site 526227005728 dimer interface [polypeptide binding]; other site 526227005729 putative PBP binding regions; other site 526227005730 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 526227005731 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 526227005732 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 526227005733 putative hemin binding site; other site 526227005734 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 526227005735 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 526227005736 Protein of unknown function (DUF3234); Region: DUF3234; pfam11572 526227005737 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 526227005738 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227005739 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 526227005740 glycyl-tRNA synthetase; Provisional; Region: PRK04173 526227005741 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 526227005742 motif 1; other site 526227005743 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 526227005744 active site 526227005745 motif 2; other site 526227005746 motif 3; other site 526227005747 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 526227005748 anticodon binding site; other site 526227005749 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 526227005750 Clp amino terminal domain; Region: Clp_N; pfam02861 526227005751 Clp amino terminal domain; Region: Clp_N; pfam02861 526227005752 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227005753 Walker A motif; other site 526227005754 ATP binding site [chemical binding]; other site 526227005755 Walker B motif; other site 526227005756 arginine finger; other site 526227005757 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227005758 Walker A motif; other site 526227005759 ATP binding site [chemical binding]; other site 526227005760 Walker B motif; other site 526227005761 arginine finger; other site 526227005762 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 526227005763 DNA repair protein RadA; Provisional; Region: PRK11823 526227005764 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227005765 Walker A motif; other site 526227005766 ATP binding site [chemical binding]; other site 526227005767 Walker B motif; other site 526227005768 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 526227005769 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 526227005770 putative active site [active] 526227005771 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 526227005772 ATP-grasp domain; Region: ATP-grasp_4; cl03087 526227005773 CoA-ligase; Region: Ligase_CoA; cl02894 526227005774 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 526227005775 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227005776 CoA-ligase; Region: Ligase_CoA; cl02894 526227005777 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 526227005778 active site 526227005779 catalytic residues [active] 526227005780 metal binding site [ion binding]; metal-binding site 526227005781 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 526227005782 Protein of unknown function (DUF433); Region: DUF433; cl01030 526227005783 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 526227005784 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 526227005785 GMP synthase; Reviewed; Region: guaA; PRK00074 526227005786 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 526227005787 AMP/PPi binding site [chemical binding]; other site 526227005788 candidate oxyanion hole; other site 526227005789 catalytic triad [active] 526227005790 potential glutamine specificity residues [chemical binding]; other site 526227005791 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 526227005792 ATP Binding subdomain [chemical binding]; other site 526227005793 Ligand Binding sites [chemical binding]; other site 526227005794 Dimerization subdomain; other site 526227005795 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 526227005796 Fe-S cluster binding site [ion binding]; other site 526227005797 active site 526227005798 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 526227005799 EamA-like transporter family; Region: EamA; cl01037 526227005800 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 526227005801 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 526227005802 tetramerization interface [polypeptide binding]; other site 526227005803 NAD(P) binding site [chemical binding]; other site 526227005804 catalytic residues [active] 526227005805 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 526227005806 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 526227005807 purine monophosphate binding site [chemical binding]; other site 526227005808 dimer interface [polypeptide binding]; other site 526227005809 putative catalytic residues [active] 526227005810 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 526227005811 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 526227005812 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227005813 GatB domain; Region: GatB_Yqey; cl11497 526227005814 Helix-turn-helix domains; Region: HTH; cl00088 526227005815 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 526227005816 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 526227005817 putative transposase OrfB; Reviewed; Region: PHA02517 526227005818 Integrase core domain; Region: rve; cl01316 526227005819 Integrase core domain; Region: rve_3; cl15866 526227005820 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 526227005821 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 526227005822 Walker A/P-loop; other site 526227005823 ATP binding site [chemical binding]; other site 526227005824 Q-loop/lid; other site 526227005825 ABC transporter signature motif; other site 526227005826 Walker B; other site 526227005827 D-loop; other site 526227005828 H-loop/switch region; other site 526227005829 TOBE domain; Region: TOBE_2; cl01440 526227005830 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 526227005831 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 526227005832 ATP-binding site [chemical binding]; other site 526227005833 Sugar specificity; other site 526227005834 Pyrimidine base specificity; other site 526227005835 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 526227005836 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 526227005837 active site 526227005838 catalytic site [active] 526227005839 substrate binding site [chemical binding]; other site 526227005840 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 526227005841 Amidase; Region: Amidase; cl11426 526227005842 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227005843 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 526227005844 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 526227005845 putative dimer interface [polypeptide binding]; other site 526227005846 thymidine kinase; Provisional; Region: PRK04296 526227005847 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 526227005848 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 526227005849 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 526227005850 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 526227005851 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 526227005852 intersubunit interface [polypeptide binding]; other site 526227005853 dephospho-CoA kinase; Region: TIGR00152 526227005854 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 526227005855 CoA-binding site [chemical binding]; other site 526227005856 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 526227005857 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 526227005858 active site 526227005859 NTP binding site [chemical binding]; other site 526227005860 metal binding triad [ion binding]; metal-binding site 526227005861 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 526227005862 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 526227005863 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 526227005864 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 526227005865 ribonuclease R; Region: RNase_R; TIGR02063 526227005866 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 526227005867 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 526227005868 RNB domain; Region: RNB; pfam00773 526227005869 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 526227005870 RNA binding site [nucleotide binding]; other site 526227005871 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 526227005872 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 526227005873 inhibitor-cofactor binding pocket; inhibition site 526227005874 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227005875 catalytic residue [active] 526227005876 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 526227005877 active site 526227005878 Ribosome-binding factor A; Region: RBFA; cl00542 526227005879 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14323 526227005880 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 526227005881 active site 526227005882 substrate binding site [chemical binding]; other site 526227005883 metal binding site [ion binding]; metal-binding site 526227005884 DNA polymerase I; Provisional; Region: PRK05755 526227005885 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 526227005886 active site 526227005887 metal binding site 1 [ion binding]; metal-binding site 526227005888 putative 5' ssDNA interaction site; other site 526227005889 metal binding site 3; metal-binding site 526227005890 metal binding site 2 [ion binding]; metal-binding site 526227005891 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 526227005892 putative DNA binding site [nucleotide binding]; other site 526227005893 putative metal binding site [ion binding]; other site 526227005894 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 526227005895 active site 526227005896 catalytic site [active] 526227005897 substrate binding site [chemical binding]; other site 526227005898 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 526227005899 active site 526227005900 DNA binding site [nucleotide binding] 526227005901 catalytic site [active] 526227005902 Uncharacterized conserved protein [Function unknown]; Region: COG1739 526227005903 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 526227005904 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 526227005905 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 526227005906 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 526227005907 shikimate binding site; other site 526227005908 NAD(P) binding site [chemical binding]; other site 526227005909 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 526227005910 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 526227005911 dimer interface [polypeptide binding]; other site 526227005912 active site residues [active] 526227005913 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 526227005914 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 526227005915 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227005916 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 526227005917 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 526227005918 Domain of unknown function DUF21; Region: DUF21; pfam01595 526227005919 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 526227005920 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 526227005921 Transporter associated domain; Region: CorC_HlyC; cl08393 526227005922 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 526227005923 active site 526227005924 catalytic motif [active] 526227005925 Zn binding site [ion binding]; other site 526227005926 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 526227005927 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 526227005928 inhibitor site; inhibition site 526227005929 active site 526227005930 dimer interface [polypeptide binding]; other site 526227005931 catalytic residue [active] 526227005932 Filamin/ABP280 repeat; Region: Filamin; cl02665 526227005933 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 526227005934 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 526227005935 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 526227005936 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 526227005937 Cation efflux family; Region: Cation_efflux; cl00316 526227005938 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 526227005939 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 526227005940 dimer interface [polypeptide binding]; other site 526227005941 putative anticodon binding site; other site 526227005942 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 526227005943 motif 1; other site 526227005944 active site 526227005945 motif 2; other site 526227005946 motif 3; other site 526227005947 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 526227005948 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 526227005949 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 526227005950 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 526227005951 Helix-turn-helix domains; Region: HTH; cl00088 526227005952 Outer membrane efflux protein; Region: OEP; pfam02321 526227005953 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 526227005954 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 526227005955 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 526227005956 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 526227005957 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 526227005958 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 526227005959 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 526227005960 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 526227005961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227005962 putative substrate translocation pore; other site 526227005963 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 526227005964 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526227005965 ATP binding site [chemical binding]; other site 526227005966 putative Mg++ binding site [ion binding]; other site 526227005967 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526227005968 nucleotide binding region [chemical binding]; other site 526227005969 ATP-binding site [chemical binding]; other site 526227005970 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 526227005971 potassium/proton antiporter; Reviewed; Region: PRK05326 526227005972 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 526227005973 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 526227005974 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227005975 GTP/Mg2+ binding site [chemical binding]; other site 526227005976 G5 box; other site 526227005977 trmE is a tRNA modification GTPase; Region: trmE; cd04164 526227005978 G1 box; other site 526227005979 G1 box; other site 526227005980 GTP/Mg2+ binding site [chemical binding]; other site 526227005981 Switch I region; other site 526227005982 Switch I region; other site 526227005983 G2 box; other site 526227005984 G2 box; other site 526227005985 Switch II region; other site 526227005986 G3 box; other site 526227005987 G4 box; other site 526227005988 G5 box; other site 526227005989 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 526227005990 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 526227005991 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 526227005992 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227005993 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 526227005994 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 526227005995 Family of unknown function (DUF490); Region: DUF490; pfam04357 526227005996 Acylphosphatase; Region: Acylphosphatase; cl00551 526227005997 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 526227005998 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 526227005999 HflX GTPase family; Region: HflX; cd01878 526227006000 G1 box; other site 526227006001 GTP/Mg2+ binding site [chemical binding]; other site 526227006002 Switch I region; other site 526227006003 G2 box; other site 526227006004 G3 box; other site 526227006005 Switch II region; other site 526227006006 G4 box; other site 526227006007 G5 box; other site 526227006008 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 526227006009 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526227006010 active site 526227006011 motif I; other site 526227006012 motif II; other site 526227006013 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 526227006014 putative active site [active] 526227006015 DivIVA protein; Region: DivIVA; pfam05103 526227006016 DivIVA domain; Region: DivI1A_domain; TIGR03544 526227006017 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 526227006018 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 526227006019 catalytic residue [active] 526227006020 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 526227006021 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 526227006022 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 526227006023 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 526227006024 Surface antigen; Region: Bac_surface_Ag; cl03097 526227006025 cyclase homology domain; Region: CHD; cd07302 526227006026 nucleotidyl binding site; other site 526227006027 metal binding site [ion binding]; metal-binding site 526227006028 dimer interface [polypeptide binding]; other site 526227006029 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227006030 CHC2 zinc finger; Region: zf-CHC2; cl15369 526227006031 DNA primase; Validated; Region: dnaG; PRK05667 526227006032 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 526227006033 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 526227006034 active site 526227006035 metal binding site [ion binding]; metal-binding site 526227006036 interdomain interaction site; other site 526227006037 Rrf2 family protein; Region: rrf2_super; TIGR00738 526227006038 Helix-turn-helix domains; Region: HTH; cl00088 526227006039 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 526227006040 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 526227006041 active site residue [active] 526227006042 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 526227006043 active site residue [active] 526227006044 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 526227006045 active site residue [active] 526227006046 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 526227006047 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 526227006048 ATP-grasp domain; Region: ATP-grasp_4; cl03087 526227006049 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 526227006050 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 526227006051 ATP-grasp domain; Region: ATP-grasp_4; cl03087 526227006052 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 526227006053 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 526227006054 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13829 526227006055 RimM N-terminal domain; Region: RimM; pfam01782 526227006056 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 526227006057 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 526227006058 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 526227006059 signal recognition particle protein; Provisional; Region: PRK10867 526227006060 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 526227006061 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 526227006062 P loop; other site 526227006063 GTP binding site [chemical binding]; other site 526227006064 Signal peptide binding domain; Region: SRP_SPB; pfam02978 526227006065 Domain of unknown function (DUF305); Region: DUF305; cl15795 526227006066 Domain of unknown function (DUF305); Region: DUF305; cl15795 526227006067 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 526227006068 MgtE intracellular N domain; Region: MgtE_N; cl15244 526227006069 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 526227006070 Divalent cation transporter; Region: MgtE; cl00786 526227006071 DDE superfamily endonuclease; Region: DDE_4; cl15789 526227006072 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227006073 Arginase family; Region: Arginase; cl00306 526227006074 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 526227006075 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 526227006076 putative active site [active] 526227006077 putative substrate binding site [chemical binding]; other site 526227006078 ATP binding site [chemical binding]; other site 526227006079 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 526227006080 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526227006081 active site 526227006082 Restriction endonuclease; Region: Mrr_cat; cl00516 526227006083 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 526227006084 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 526227006085 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 526227006086 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 526227006087 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 526227006088 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 526227006089 DNA binding residues [nucleotide binding] 526227006090 MOSC domain; Region: MOSC; pfam03473 526227006091 Fe-S metabolism associated domain; Region: SufE; cl00951 526227006092 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 526227006093 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 526227006094 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 526227006095 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526227006096 MULE transposase domain; Region: MULE; pfam10551 526227006097 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 526227006098 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227006099 Walker A/P-loop; other site 526227006100 ATP binding site [chemical binding]; other site 526227006101 Q-loop/lid; other site 526227006102 putative transposase OrfB; Reviewed; Region: PHA02517 526227006103 Integrase core domain; Region: rve; cl01316 526227006104 Integrase core domain; Region: rve_3; cl15866 526227006105 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 526227006106 dimerization interface [polypeptide binding]; other site 526227006107 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 526227006108 Zn2+ binding site [ion binding]; other site 526227006109 Mg2+ binding site [ion binding]; other site 526227006110 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 526227006111 Helix-turn-helix domains; Region: HTH; cl00088 526227006112 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 526227006113 dihydrodipicolinate synthase; Region: dapA; TIGR00674 526227006114 dimer interface [polypeptide binding]; other site 526227006115 active site 526227006116 catalytic residue [active] 526227006117 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 526227006118 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 526227006119 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 526227006120 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 526227006121 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 526227006122 NAD binding site [chemical binding]; other site 526227006123 catalytic residues [active] 526227006124 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 526227006125 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 526227006126 Flavin Reductases; Region: FlaRed; cl00801 526227006127 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 526227006128 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 526227006129 active site 526227006130 metal binding site [ion binding]; metal-binding site 526227006131 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 526227006132 tetramer interface [polypeptide binding]; other site 526227006133 active site 526227006134 metal binding site [ion binding]; metal-binding site 526227006135 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 526227006136 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 526227006137 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 526227006138 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 526227006139 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 526227006140 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 526227006141 putative ligand binding site [chemical binding]; other site 526227006142 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 526227006143 TM-ABC transporter signature motif; other site 526227006144 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 526227006145 TM-ABC transporter signature motif; other site 526227006146 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 526227006147 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 526227006148 Walker A/P-loop; other site 526227006149 ATP binding site [chemical binding]; other site 526227006150 Q-loop/lid; other site 526227006151 ABC transporter signature motif; other site 526227006152 Walker B; other site 526227006153 D-loop; other site 526227006154 H-loop/switch region; other site 526227006155 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 526227006156 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 526227006157 Walker A/P-loop; other site 526227006158 ATP binding site [chemical binding]; other site 526227006159 Q-loop/lid; other site 526227006160 ABC transporter signature motif; other site 526227006161 Walker B; other site 526227006162 D-loop; other site 526227006163 H-loop/switch region; other site 526227006164 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 526227006165 CoenzymeA binding site [chemical binding]; other site 526227006166 subunit interaction site [polypeptide binding]; other site 526227006167 PHB binding site; other site 526227006168 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 526227006169 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 526227006170 dimer interface [polypeptide binding]; other site 526227006171 active site 526227006172 AMP-binding enzyme; Region: AMP-binding; cl15778 526227006173 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 526227006174 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 526227006175 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 526227006176 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 526227006177 hypothetical protein; Validated; Region: PRK06840 526227006178 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 526227006179 active site 526227006180 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 526227006181 AMP-binding enzyme; Region: AMP-binding; cl15778 526227006182 AMP-binding enzyme; Region: AMP-binding; cl15778 526227006183 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 526227006184 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 526227006185 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 526227006186 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 526227006187 dimer interaction site [polypeptide binding]; other site 526227006188 substrate-binding tunnel; other site 526227006189 active site 526227006190 catalytic site [active] 526227006191 substrate binding site [chemical binding]; other site 526227006192 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 526227006193 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 526227006194 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 526227006195 TM-ABC transporter signature motif; other site 526227006196 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 526227006197 TM-ABC transporter signature motif; other site 526227006198 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 526227006199 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 526227006200 Walker A/P-loop; other site 526227006201 ATP binding site [chemical binding]; other site 526227006202 Q-loop/lid; other site 526227006203 ABC transporter signature motif; other site 526227006204 Walker B; other site 526227006205 D-loop; other site 526227006206 H-loop/switch region; other site 526227006207 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 526227006208 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 526227006209 Walker A/P-loop; other site 526227006210 ATP binding site [chemical binding]; other site 526227006211 Q-loop/lid; other site 526227006212 ABC transporter signature motif; other site 526227006213 Walker B; other site 526227006214 D-loop; other site 526227006215 H-loop/switch region; other site 526227006216 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227006217 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 526227006218 NAD(P) binding site [chemical binding]; other site 526227006219 active site 526227006220 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 526227006221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227006222 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 526227006223 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 526227006224 Subunit I/III interface [polypeptide binding]; other site 526227006225 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 526227006226 Subunit I/III interface [polypeptide binding]; other site 526227006227 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 526227006228 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 526227006229 D-pathway; other site 526227006230 Low-spin heme binding site [chemical binding]; other site 526227006231 Putative water exit pathway; other site 526227006232 Binuclear center (active site) [active] 526227006233 K-pathway; other site 526227006234 Putative proton exit pathway; other site 526227006235 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 526227006236 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 526227006237 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 526227006238 hydrophobic ligand binding site; other site 526227006239 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 526227006240 active site 526227006241 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 526227006242 Bifunctional nuclease; Region: DNase-RNase; cl00553 526227006243 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 526227006244 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 526227006245 active site 526227006246 metal binding site [ion binding]; metal-binding site 526227006247 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 526227006248 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 526227006249 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 526227006250 FeS/SAM binding site; other site 526227006251 serine racemase; Region: PLN02970 526227006252 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 526227006253 tetramer interface [polypeptide binding]; other site 526227006254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227006255 catalytic residue [active] 526227006256 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 526227006257 DinB superfamily; Region: DinB_2; pfam12867 526227006258 Predicted membrane protein [Function unknown]; Region: COG2311 526227006259 Protein of unknown function (DUF418); Region: DUF418; cl12135 526227006260 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 526227006261 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 526227006262 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 526227006263 catalytic site [active] 526227006264 subunit interface [polypeptide binding]; other site 526227006265 Domain of unknown function (DUF1887); Region: DUF1887; pfam09002 526227006266 Restriction endonuclease; Region: Mrr_cat; cl00516 526227006267 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 526227006268 argininosuccinate lyase; Provisional; Region: PRK00855 526227006269 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 526227006270 active sites [active] 526227006271 tetramer interface [polypeptide binding]; other site 526227006272 amino-acid N-acetyltransferase; Region: PLN02825 526227006273 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526227006274 Coenzyme A binding pocket [chemical binding]; other site 526227006275 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 526227006276 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 526227006277 ANP binding site [chemical binding]; other site 526227006278 Substrate Binding Site II [chemical binding]; other site 526227006279 Substrate Binding Site I [chemical binding]; other site 526227006280 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227006281 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227006282 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526227006283 metal binding site [ion binding]; metal-binding site 526227006284 active site 526227006285 I-site; other site 526227006286 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 526227006287 histidinol dehydrogenase; Region: hisD; TIGR00069 526227006288 NAD binding site [chemical binding]; other site 526227006289 dimerization interface [polypeptide binding]; other site 526227006290 product binding site; other site 526227006291 substrate binding site [chemical binding]; other site 526227006292 zinc binding site [ion binding]; other site 526227006293 catalytic residues [active] 526227006294 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 526227006295 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 526227006296 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 526227006297 GTP-binding protein LepA; Provisional; Region: PRK05433 526227006298 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 526227006299 G1 box; other site 526227006300 putative GEF interaction site [polypeptide binding]; other site 526227006301 GTP/Mg2+ binding site [chemical binding]; other site 526227006302 Switch I region; other site 526227006303 G2 box; other site 526227006304 G3 box; other site 526227006305 Switch II region; other site 526227006306 G4 box; other site 526227006307 G5 box; other site 526227006308 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 526227006309 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 526227006310 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 526227006311 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 526227006312 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227006313 ATP binding site [chemical binding]; other site 526227006314 Mg2+ binding site [ion binding]; other site 526227006315 G-X-G motif; other site 526227006316 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526227006317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227006318 active site 526227006319 phosphorylation site [posttranslational modification] 526227006320 intermolecular recognition site; other site 526227006321 dimerization interface [polypeptide binding]; other site 526227006322 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526227006323 DNA binding residues [nucleotide binding] 526227006324 dimerization interface [polypeptide binding]; other site 526227006325 Nitrogen regulatory protein P-II; Region: P-II; cl00412 526227006326 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 526227006327 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 526227006328 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227006329 S-adenosylmethionine binding site [chemical binding]; other site 526227006330 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 526227006331 Domain of unknown function (DUF814); Region: DUF814; pfam05670 526227006332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227006333 dimer interface [polypeptide binding]; other site 526227006334 conserved gate region; other site 526227006335 putative PBP binding loops; other site 526227006336 ABC-ATPase subunit interface; other site 526227006337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 526227006338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227006339 putative PBP binding loops; other site 526227006340 ABC-ATPase subunit interface; other site 526227006341 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 526227006342 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227006343 Helix-turn-helix domains; Region: HTH; cl00088 526227006344 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 526227006345 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 526227006346 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 526227006347 dimerization interface [polypeptide binding]; other site 526227006348 putative tRNAtyr binding site [nucleotide binding]; other site 526227006349 putative active site [active] 526227006350 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 526227006351 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 526227006352 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 526227006353 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227006354 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 526227006355 putative L-serine binding site [chemical binding]; other site 526227006356 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 526227006357 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 526227006358 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526227006359 catalytic residue [active] 526227006360 UbiA prenyltransferase family; Region: UbiA; cl00337 526227006361 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 526227006362 Helix-turn-helix domains; Region: HTH; cl00088 526227006363 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 526227006364 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 526227006365 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227006366 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 526227006367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227006368 dimer interface [polypeptide binding]; other site 526227006369 conserved gate region; other site 526227006370 putative PBP binding loops; other site 526227006371 ABC-ATPase subunit interface; other site 526227006372 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 526227006373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227006374 dimer interface [polypeptide binding]; other site 526227006375 conserved gate region; other site 526227006376 putative PBP binding loops; other site 526227006377 ABC-ATPase subunit interface; other site 526227006378 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 526227006379 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 526227006380 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 526227006381 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 526227006382 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 526227006383 nucleotide binding site/active site [active] 526227006384 HIT family signature motif; other site 526227006385 catalytic residue [active] 526227006386 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 526227006387 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 526227006388 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 526227006389 active site 526227006390 galactokinase; Provisional; Region: PRK05101 526227006391 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 526227006392 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 526227006393 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 526227006394 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 526227006395 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 526227006396 dimerization interface [polypeptide binding]; other site 526227006397 domain crossover interface; other site 526227006398 redox-dependent activation switch; other site 526227006399 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 526227006400 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 526227006401 inhibitor-cofactor binding pocket; inhibition site 526227006402 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227006403 catalytic residue [active] 526227006404 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 526227006405 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 526227006406 Walker A/P-loop; other site 526227006407 ATP binding site [chemical binding]; other site 526227006408 Q-loop/lid; other site 526227006409 ABC transporter signature motif; other site 526227006410 Walker B; other site 526227006411 D-loop; other site 526227006412 H-loop/switch region; other site 526227006413 TOBE domain; Region: TOBE_2; cl01440 526227006414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227006415 dimer interface [polypeptide binding]; other site 526227006416 conserved gate region; other site 526227006417 putative PBP binding loops; other site 526227006418 ABC-ATPase subunit interface; other site 526227006419 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 526227006420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227006421 dimer interface [polypeptide binding]; other site 526227006422 conserved gate region; other site 526227006423 putative PBP binding loops; other site 526227006424 ABC-ATPase subunit interface; other site 526227006425 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 526227006426 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227006427 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 526227006428 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 526227006429 inhibitor-cofactor binding pocket; inhibition site 526227006430 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227006431 catalytic residue [active] 526227006432 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 526227006433 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227006434 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526227006435 Coenzyme A binding pocket [chemical binding]; other site 526227006436 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 526227006437 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 526227006438 active site 526227006439 putative acetyltransferase; Provisional; Region: PRK03624 526227006440 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526227006441 Coenzyme A binding pocket [chemical binding]; other site 526227006442 aminotransferase; Validated; Region: PRK07046 526227006443 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 526227006444 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526227006445 catalytic residue [active] 526227006446 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227006447 FAD dependent oxidoreductase; Region: DAO; pfam01266 526227006448 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 526227006449 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 526227006450 tetrameric interface [polypeptide binding]; other site 526227006451 NAD binding site [chemical binding]; other site 526227006452 catalytic residues [active] 526227006453 substrate binding site [chemical binding]; other site 526227006454 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 526227006455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227006456 dimer interface [polypeptide binding]; other site 526227006457 conserved gate region; other site 526227006458 putative PBP binding loops; other site 526227006459 ABC-ATPase subunit interface; other site 526227006460 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 526227006461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227006462 putative PBP binding loops; other site 526227006463 dimer interface [polypeptide binding]; other site 526227006464 ABC-ATPase subunit interface; other site 526227006465 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 526227006466 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227006467 Walker A/P-loop; other site 526227006468 ATP binding site [chemical binding]; other site 526227006469 Q-loop/lid; other site 526227006470 ABC transporter signature motif; other site 526227006471 Walker B; other site 526227006472 D-loop; other site 526227006473 H-loop/switch region; other site 526227006474 TOBE domain; Region: TOBE_2; cl01440 526227006475 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 526227006476 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227006477 Transcriptional regulator [Transcription]; Region: LysR; COG0583 526227006478 Helix-turn-helix domains; Region: HTH; cl00088 526227006479 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 526227006480 putative substrate binding pocket [chemical binding]; other site 526227006481 dimerization interface [polypeptide binding]; other site 526227006482 Protein of unknown function (DUF3197); Region: DUF3197; pfam11432 526227006483 Domain of unknown function DUF59; Region: DUF59; cl00941 526227006484 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 526227006485 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 526227006486 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 526227006487 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 526227006488 active site 526227006489 metal binding site [ion binding]; metal-binding site 526227006490 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 526227006491 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 526227006492 4Fe-4S binding domain; Region: Fer4; cl02805 526227006493 Cysteine-rich domain; Region: CCG; pfam02754 526227006494 Cysteine-rich domain; Region: CCG; pfam02754 526227006495 Bacterial transcriptional activator domain; Region: BTAD; smart01043 526227006496 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227006497 putative transposase OrfB; Reviewed; Region: PHA02517 526227006498 Integrase core domain; Region: rve; cl01316 526227006499 Integrase core domain; Region: rve_3; cl15866 526227006500 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 526227006501 DinB superfamily; Region: DinB_2; pfam12867 526227006502 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 526227006503 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 526227006504 Divergent PAP2 family; Region: DUF212; cl00855 526227006505 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14173 526227006506 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 526227006507 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 526227006508 homodimer interface [polypeptide binding]; other site 526227006509 NADP binding site [chemical binding]; other site 526227006510 substrate binding site [chemical binding]; other site 526227006511 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 526227006512 putative RNA binding site [nucleotide binding]; other site 526227006513 Asp23 family; Region: Asp23; cl00574 526227006514 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 526227006515 TM-ABC transporter signature motif; other site 526227006516 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 526227006517 AMP-binding enzyme; Region: AMP-binding; cl15778 526227006518 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 526227006519 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 526227006520 Walker A/P-loop; other site 526227006521 ATP binding site [chemical binding]; other site 526227006522 Q-loop/lid; other site 526227006523 ABC transporter signature motif; other site 526227006524 Walker B; other site 526227006525 D-loop; other site 526227006526 H-loop/switch region; other site 526227006527 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 526227006528 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 526227006529 Walker A/P-loop; other site 526227006530 ATP binding site [chemical binding]; other site 526227006531 Q-loop/lid; other site 526227006532 ABC transporter signature motif; other site 526227006533 Walker B; other site 526227006534 D-loop; other site 526227006535 H-loop/switch region; other site 526227006536 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 526227006537 TM-ABC transporter signature motif; other site 526227006538 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 526227006539 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 526227006540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 526227006541 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 526227006542 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 526227006543 Deoxyhypusine synthase; Region: DS; cl00826 526227006544 putative transposase OrfB; Reviewed; Region: PHA02517 526227006545 Integrase core domain; Region: rve; cl01316 526227006546 Integrase core domain; Region: rve_3; cl15866 526227006547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227006548 putative substrate translocation pore; other site 526227006549 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 526227006550 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 526227006551 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 526227006552 active site 526227006553 HIGH motif; other site 526227006554 KMSK motif region; other site 526227006555 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 526227006556 tRNA binding surface [nucleotide binding]; other site 526227006557 anticodon binding site; other site 526227006558 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 526227006559 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 526227006560 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 526227006561 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 526227006562 Substrate-binding site [chemical binding]; other site 526227006563 Substrate specificity [chemical binding]; other site 526227006564 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 526227006565 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 526227006566 Substrate-binding site [chemical binding]; other site 526227006567 Substrate specificity [chemical binding]; other site 526227006568 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 526227006569 agmatine deiminase; Region: agmatine_aguA; TIGR03380 526227006570 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 526227006571 N-carbamolyputrescine amidase; Region: PLN02747 526227006572 putative active site; other site 526227006573 catalytic triad [active] 526227006574 putative dimer interface [polypeptide binding]; other site 526227006575 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 526227006576 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 526227006577 active site 526227006578 catalytic residues [active] 526227006579 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 526227006580 GAF domain; Region: GAF; cl15785 526227006581 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526227006582 metal binding site [ion binding]; metal-binding site 526227006583 active site 526227006584 I-site; other site 526227006585 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 526227006586 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 526227006587 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 526227006588 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 526227006589 Uncharacterized conserved protein [Function unknown]; Region: COG0327 526227006590 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 526227006591 thymidylate kinase; Validated; Region: tmk; PRK00698 526227006592 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 526227006593 TMP-binding site; other site 526227006594 ATP-binding site [chemical binding]; other site 526227006595 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 526227006596 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 526227006597 tetramer interface [polypeptide binding]; other site 526227006598 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 526227006599 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227006600 dimer interface [polypeptide binding]; other site 526227006601 conserved gate region; other site 526227006602 putative PBP binding loops; other site 526227006603 ABC-ATPase subunit interface; other site 526227006604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227006605 dimer interface [polypeptide binding]; other site 526227006606 conserved gate region; other site 526227006607 putative PBP binding loops; other site 526227006608 ABC-ATPase subunit interface; other site 526227006609 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 526227006610 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227006611 HflC protein; Region: hflC; TIGR01932 526227006612 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 526227006613 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 526227006614 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 526227006615 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 526227006616 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 526227006617 putative peptidoglycan binding site; other site 526227006618 Peptidase family M23; Region: Peptidase_M23; pfam01551 526227006619 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 526227006620 trimer interface [polypeptide binding]; other site 526227006621 active site 526227006622 dimer interface [polypeptide binding]; other site 526227006623 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 526227006624 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 526227006625 DNA gyrase subunit A; Validated; Region: PRK05560 526227006626 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 526227006627 CAP-like domain; other site 526227006628 active site 526227006629 primary dimer interface [polypeptide binding]; other site 526227006630 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 526227006631 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 526227006632 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 526227006633 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 526227006634 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 526227006635 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 526227006636 NAD(P) binding site [chemical binding]; other site 526227006637 short chain dehydrogenase; Provisional; Region: PRK07677 526227006638 substrate binding site [chemical binding]; other site 526227006639 homotetramer interface [polypeptide binding]; other site 526227006640 active site 526227006641 homodimer interface [polypeptide binding]; other site 526227006642 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 526227006643 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 526227006644 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 526227006645 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227006646 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 526227006647 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 526227006648 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 526227006649 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 526227006650 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 526227006651 putative active site [active] 526227006652 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 526227006653 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 526227006654 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 526227006655 CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918 526227006656 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 526227006657 ligand binding site [chemical binding]; other site 526227006658 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 526227006659 putative switch regulator; other site 526227006660 non-specific DNA interactions [nucleotide binding]; other site 526227006661 DNA binding site [nucleotide binding] 526227006662 sequence specific DNA binding site [nucleotide binding]; other site 526227006663 putative cAMP binding site [chemical binding]; other site 526227006664 putative transposase OrfB; Reviewed; Region: PHA02517 526227006665 Integrase core domain; Region: rve; cl01316 526227006666 Integrase core domain; Region: rve_3; cl15866 526227006667 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 526227006668 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227006669 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 526227006670 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 526227006671 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 526227006672 active site 526227006673 metal binding site [ion binding]; metal-binding site 526227006674 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 526227006675 Probable transposase; Region: OrfB_IS605; pfam01385 526227006676 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 526227006677 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 526227006678 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 526227006679 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 526227006680 glutamine synthetase, type I; Region: GlnA; TIGR00653 526227006681 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 526227006682 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 526227006683 putative transposase OrfB; Reviewed; Region: PHA02517 526227006684 Integrase core domain; Region: rve; cl01316 526227006685 Integrase core domain; Region: rve_3; cl15866 526227006686 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 526227006687 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 526227006688 dimerization interface [polypeptide binding]; other site 526227006689 ligand binding site [chemical binding]; other site 526227006690 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 526227006691 TM-ABC transporter signature motif; other site 526227006692 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 526227006693 TM-ABC transporter signature motif; other site 526227006694 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 526227006695 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 526227006696 Walker A/P-loop; other site 526227006697 ATP binding site [chemical binding]; other site 526227006698 Q-loop/lid; other site 526227006699 ABC transporter signature motif; other site 526227006700 Walker B; other site 526227006701 D-loop; other site 526227006702 H-loop/switch region; other site 526227006703 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 526227006704 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 526227006705 Walker A/P-loop; other site 526227006706 ATP binding site [chemical binding]; other site 526227006707 Q-loop/lid; other site 526227006708 ABC transporter signature motif; other site 526227006709 Walker B; other site 526227006710 D-loop; other site 526227006711 H-loop/switch region; other site 526227006712 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 526227006713 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 526227006714 peptide binding site [polypeptide binding]; other site 526227006715 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 526227006716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227006717 dimer interface [polypeptide binding]; other site 526227006718 conserved gate region; other site 526227006719 putative PBP binding loops; other site 526227006720 ABC-ATPase subunit interface; other site 526227006721 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 526227006722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227006723 dimer interface [polypeptide binding]; other site 526227006724 conserved gate region; other site 526227006725 putative PBP binding loops; other site 526227006726 ABC-ATPase subunit interface; other site 526227006727 PrcB C-terminal; Region: PrcB_C; pfam14343 526227006728 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 526227006729 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 526227006730 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 526227006731 MPT binding site; other site 526227006732 trimer interface [polypeptide binding]; other site 526227006733 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 526227006734 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 526227006735 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 526227006736 Walker A/P-loop; other site 526227006737 ATP binding site [chemical binding]; other site 526227006738 Q-loop/lid; other site 526227006739 ABC transporter signature motif; other site 526227006740 Walker B; other site 526227006741 D-loop; other site 526227006742 H-loop/switch region; other site 526227006743 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 526227006744 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 526227006745 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227006746 Walker A/P-loop; other site 526227006747 ATP binding site [chemical binding]; other site 526227006748 Q-loop/lid; other site 526227006749 ABC transporter signature motif; other site 526227006750 Walker B; other site 526227006751 D-loop; other site 526227006752 H-loop/switch region; other site 526227006753 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 526227006754 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 526227006755 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 526227006756 metal binding site [ion binding]; metal-binding site 526227006757 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526227006758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227006759 active site 526227006760 phosphorylation site [posttranslational modification] 526227006761 intermolecular recognition site; other site 526227006762 dimerization interface [polypeptide binding]; other site 526227006763 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526227006764 DNA binding residues [nucleotide binding] 526227006765 dimerization interface [polypeptide binding]; other site 526227006766 Helix-turn-helix domains; Region: HTH; cl00088 526227006767 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 526227006768 Phosphotransferase enzyme family; Region: APH; pfam01636 526227006769 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 526227006770 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 526227006771 active site 526227006772 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 526227006773 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 526227006774 Mg++ binding site [ion binding]; other site 526227006775 putative catalytic motif [active] 526227006776 substrate binding site [chemical binding]; other site 526227006777 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 526227006778 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 526227006779 active site 526227006780 homodimer interface [polypeptide binding]; other site 526227006781 Transmembrane secretion effector; Region: MFS_3; pfam05977 526227006782 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227006783 NMT1-like family; Region: NMT1_2; cl15260 526227006784 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 526227006785 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 526227006786 acyl-coenzyme A oxidase; Region: PLN02526 526227006787 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526227006788 active site 526227006789 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 526227006790 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 526227006791 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 526227006792 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 526227006793 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 526227006794 DinB superfamily; Region: DinB_2; pfam12867 526227006795 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 526227006796 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 526227006797 NAD(P) binding site [chemical binding]; other site 526227006798 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 526227006799 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 526227006800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227006801 dimer interface [polypeptide binding]; other site 526227006802 conserved gate region; other site 526227006803 putative PBP binding loops; other site 526227006804 ABC-ATPase subunit interface; other site 526227006805 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 526227006806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227006807 putative PBP binding loops; other site 526227006808 dimer interface [polypeptide binding]; other site 526227006809 ABC-ATPase subunit interface; other site 526227006810 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 526227006811 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 526227006812 Chromate transporter; Region: Chromate_transp; pfam02417 526227006813 Chromate transporter; Region: Chromate_transp; pfam02417 526227006814 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 526227006815 active site 526227006816 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 526227006817 active site 526227006818 putative substrate binding region [chemical binding]; other site 526227006819 FOG: CBS domain [General function prediction only]; Region: COG0517 526227006820 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 526227006821 glyoxylate reductase; Reviewed; Region: PRK13243 526227006822 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227006823 HupE / UreJ protein; Region: HupE_UreJ; cl01011 526227006824 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227006825 binding surface 526227006826 TPR motif; other site 526227006827 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227006828 binding surface 526227006829 TPR motif; other site 526227006830 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227006831 binding surface 526227006832 TPR motif; other site 526227006833 TPR repeat; Region: TPR_11; pfam13414 526227006834 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 526227006835 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 526227006836 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 526227006837 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 526227006838 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 526227006839 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222 526227006840 active site 526227006841 RNA/DNA hybrid binding site [nucleotide binding]; other site 526227006842 Predicted transcriptional regulator [Transcription]; Region: COG2345 526227006843 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526227006844 putative DNA binding site [nucleotide binding]; other site 526227006845 putative Zn2+ binding site [ion binding]; other site 526227006846 Domain of unknown function DUF59; Region: DUF59; cl00941 526227006847 antiporter inner membrane protein; Provisional; Region: PRK11670 526227006848 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 526227006849 Walker A motif; other site 526227006850 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 526227006851 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cl00891 526227006852 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 526227006853 hydrophobic ligand binding site; other site 526227006854 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 526227006855 Predicted ATPase [General function prediction only]; Region: COG3903 526227006856 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227006857 TPR motif; other site 526227006858 binding surface 526227006859 TPR repeat; Region: TPR_11; pfam13414 526227006860 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227006861 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227006862 binding surface 526227006863 TPR motif; other site 526227006864 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227006865 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 526227006866 nudix motif; other site 526227006867 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 526227006868 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 526227006869 HIGH motif; other site 526227006870 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 526227006871 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 526227006872 active site 526227006873 KMSKS motif; other site 526227006874 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 526227006875 tRNA binding surface [nucleotide binding]; other site 526227006876 anticodon binding site; other site 526227006877 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 526227006878 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 526227006879 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 526227006880 DHH family; Region: DHH; pfam01368 526227006881 DHHA1 domain; Region: DHHA1; pfam02272 526227006882 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 526227006883 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 526227006884 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 526227006885 catalytic residues [active] 526227006886 Arginase family; Region: Arginase; cl00306 526227006887 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 526227006888 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 526227006889 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 526227006890 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 526227006891 dimer interface [polypeptide binding]; other site 526227006892 active site 526227006893 CoA binding pocket [chemical binding]; other site 526227006894 Acyl transferase domain; Region: Acyl_transf_1; cl08282 526227006895 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 526227006896 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 526227006897 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 526227006898 NAD(P) binding site [chemical binding]; other site 526227006899 homotetramer interface [polypeptide binding]; other site 526227006900 homodimer interface [polypeptide binding]; other site 526227006901 active site 526227006902 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 526227006903 classical (c) SDRs; Region: SDR_c; cd05233 526227006904 NAD(P) binding site [chemical binding]; other site 526227006905 active site 526227006906 Phosphopantetheine attachment site; Region: PP-binding; cl09936 526227006907 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 526227006908 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 526227006909 dimer interface [polypeptide binding]; other site 526227006910 active site 526227006911 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 526227006912 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 526227006913 Zn2+ binding site [ion binding]; other site 526227006914 Mg2+ binding site [ion binding]; other site 526227006915 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 526227006916 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 526227006917 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 526227006918 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227006919 homodimer interface [polypeptide binding]; other site 526227006920 catalytic residue [active] 526227006921 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 526227006922 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 526227006923 active site 526227006924 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 526227006925 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526227006926 MULE transposase domain; Region: MULE; pfam10551 526227006927 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 526227006928 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 526227006929 RNA binding surface [nucleotide binding]; other site 526227006930 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 526227006931 active site 526227006932 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 526227006933 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 526227006934 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227006935 Walker A motif; other site 526227006936 ATP binding site [chemical binding]; other site 526227006937 Walker B motif; other site 526227006938 arginine finger; other site 526227006939 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 526227006940 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 526227006941 Response regulator receiver domain; Region: Response_reg; pfam00072 526227006942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 526227006943 active site 526227006944 phosphorylation site [posttranslational modification] 526227006945 intermolecular recognition site; other site 526227006946 dimerization interface [polypeptide binding]; other site 526227006947 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 526227006948 Helix-turn-helix domains; Region: HTH; cl00088 526227006949 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 526227006950 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 526227006951 Walker A/P-loop; other site 526227006952 ATP binding site [chemical binding]; other site 526227006953 Q-loop/lid; other site 526227006954 ABC transporter signature motif; other site 526227006955 Walker B; other site 526227006956 D-loop; other site 526227006957 H-loop/switch region; other site 526227006958 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 526227006959 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 526227006960 Walker A/P-loop; other site 526227006961 ATP binding site [chemical binding]; other site 526227006962 Q-loop/lid; other site 526227006963 ABC transporter signature motif; other site 526227006964 Walker B; other site 526227006965 D-loop; other site 526227006966 H-loop/switch region; other site 526227006967 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 526227006968 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 526227006969 putative ligand binding site [chemical binding]; other site 526227006970 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 526227006971 TM-ABC transporter signature motif; other site 526227006972 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 526227006973 TM-ABC transporter signature motif; other site 526227006974 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526227006975 Helix-turn-helix domains; Region: HTH; cl00088 526227006976 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 526227006977 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 526227006978 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 526227006979 DNA-binding site [nucleotide binding]; DNA binding site 526227006980 UTRA domain; Region: UTRA; cl01230 526227006981 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 526227006982 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516 526227006983 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 526227006984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227006985 dimer interface [polypeptide binding]; other site 526227006986 conserved gate region; other site 526227006987 putative PBP binding loops; other site 526227006988 ABC-ATPase subunit interface; other site 526227006989 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 526227006990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227006991 dimer interface [polypeptide binding]; other site 526227006992 conserved gate region; other site 526227006993 putative PBP binding loops; other site 526227006994 ABC-ATPase subunit interface; other site 526227006995 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 526227006996 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 526227006997 putative active site [active] 526227006998 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 526227006999 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 526227007000 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 526227007001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227007002 dimer interface [polypeptide binding]; other site 526227007003 conserved gate region; other site 526227007004 putative PBP binding loops; other site 526227007005 ABC-ATPase subunit interface; other site 526227007006 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 526227007007 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 526227007008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227007009 dimer interface [polypeptide binding]; other site 526227007010 conserved gate region; other site 526227007011 putative PBP binding loops; other site 526227007012 ABC-ATPase subunit interface; other site 526227007013 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 526227007014 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 526227007015 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 526227007016 Stage II sporulation protein; Region: SpoIID; pfam08486 526227007017 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 526227007018 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 526227007019 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 526227007020 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526227007021 Coenzyme A binding pocket [chemical binding]; other site 526227007022 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 526227007023 intersubunit interface [polypeptide binding]; other site 526227007024 active site 526227007025 catalytic residue [active] 526227007026 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 526227007027 PLD-like domain; Region: PLDc_2; pfam13091 526227007028 putative active site [active] 526227007029 catalytic site [active] 526227007030 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 526227007031 PLD-like domain; Region: PLDc_2; pfam13091 526227007032 putative active site [active] 526227007033 catalytic site [active] 526227007034 Maf-like protein; Region: Maf; pfam02545 526227007035 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 526227007036 active site 526227007037 dimer interface [polypeptide binding]; other site 526227007038 rod shape-determining protein MreC; Region: MreC; pfam04085 526227007039 rod shape-determining protein MreD; Region: MreD; cl01087 526227007040 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 526227007041 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 526227007042 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 526227007043 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 526227007044 Protein of unknown function (DUF420); Region: DUF420; cl00989 526227007045 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 526227007046 dimer interface [polypeptide binding]; other site 526227007047 putative tRNA-binding site [nucleotide binding]; other site 526227007048 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 526227007049 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 526227007050 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 526227007051 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 526227007052 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 526227007053 substrate binding site [chemical binding]; other site 526227007054 ATP binding site [chemical binding]; other site 526227007055 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 526227007056 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 526227007057 putative active site [active] 526227007058 oxyanion strand; other site 526227007059 catalytic triad [active] 526227007060 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 526227007061 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 526227007062 putative active site pocket [active] 526227007063 4-fold oligomerization interface [polypeptide binding]; other site 526227007064 metal binding residues [ion binding]; metal-binding site 526227007065 3-fold/trimer interface [polypeptide binding]; other site 526227007066 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 526227007067 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 526227007068 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227007069 homodimer interface [polypeptide binding]; other site 526227007070 catalytic residue [active] 526227007071 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 526227007072 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 526227007073 TPR motif; other site 526227007074 binding surface 526227007075 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 526227007076 Found in ATP-dependent protease La (LON); Region: LON; smart00464 526227007077 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227007078 Walker A motif; other site 526227007079 ATP binding site [chemical binding]; other site 526227007080 Walker B motif; other site 526227007081 arginine finger; other site 526227007082 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 526227007083 Protein of unknown function (DUF1517); Region: DUF1517; cl01807 526227007084 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 526227007085 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 526227007086 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 526227007087 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 526227007088 Zn2+ binding site [ion binding]; other site 526227007089 Mg2+ binding site [ion binding]; other site 526227007090 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 526227007091 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 526227007092 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 526227007093 active site residue [active] 526227007094 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 526227007095 active site residue [active] 526227007096 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 526227007097 active site residue [active] 526227007098 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 526227007099 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 526227007100 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 526227007101 active site residue [active] 526227007102 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 526227007103 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 526227007104 Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973 526227007105 catalytic residues [active] 526227007106 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 526227007107 active site residue [active] 526227007108 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 526227007109 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 526227007110 catalytic residues [active] 526227007111 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 526227007112 putative homodimer interface [polypeptide binding]; other site 526227007113 putative homotetramer interface [polypeptide binding]; other site 526227007114 putative allosteric switch controlling residues; other site 526227007115 putative metal binding site [ion binding]; other site 526227007116 putative homodimer-homodimer interface [polypeptide binding]; other site 526227007117 Haemolysin-III related; Region: HlyIII; cl03831 526227007118 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526227007119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227007120 active site 526227007121 phosphorylation site [posttranslational modification] 526227007122 intermolecular recognition site; other site 526227007123 dimerization interface [polypeptide binding]; other site 526227007124 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526227007125 DNA binding site [nucleotide binding] 526227007126 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 526227007127 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 526227007128 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526227007129 dimer interface [polypeptide binding]; other site 526227007130 phosphorylation site [posttranslational modification] 526227007131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227007132 ATP binding site [chemical binding]; other site 526227007133 Mg2+ binding site [ion binding]; other site 526227007134 G-X-G motif; other site 526227007135 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 526227007136 H+ Antiporter protein; Region: 2A0121; TIGR00900 526227007137 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 526227007138 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 526227007139 Zn binding site [ion binding]; other site 526227007140 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 526227007141 active site 526227007142 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 526227007143 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227007144 S-adenosylmethionine binding site [chemical binding]; other site 526227007145 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227007146 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227007147 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526227007148 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 526227007149 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 526227007150 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227007151 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 526227007152 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 526227007153 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227007154 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 526227007155 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 526227007156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227007157 dimer interface [polypeptide binding]; other site 526227007158 conserved gate region; other site 526227007159 putative PBP binding loops; other site 526227007160 ABC-ATPase subunit interface; other site 526227007161 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 526227007162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227007163 dimer interface [polypeptide binding]; other site 526227007164 conserved gate region; other site 526227007165 putative PBP binding loops; other site 526227007166 ABC-ATPase subunit interface; other site 526227007167 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 526227007168 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227007169 DNA topoisomerase I; Validated; Region: PRK06599 526227007170 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 526227007171 active site 526227007172 interdomain interaction site; other site 526227007173 putative metal-binding site [ion binding]; other site 526227007174 nucleotide binding site [chemical binding]; other site 526227007175 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 526227007176 domain I; other site 526227007177 DNA binding groove [nucleotide binding] 526227007178 phosphate binding site [ion binding]; other site 526227007179 domain II; other site 526227007180 domain III; other site 526227007181 nucleotide binding site [chemical binding]; other site 526227007182 catalytic site [active] 526227007183 domain IV; other site 526227007184 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 526227007185 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 526227007186 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 526227007187 LysE type translocator; Region: LysE; cl00565 526227007188 Uncharacterized conserved protein [Function unknown]; Region: COG1432 526227007189 LabA_like proteins; Region: LabA_like/DUF88; cl10034 526227007190 putative metal binding site [ion binding]; other site 526227007191 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 526227007192 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227007193 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227007194 Transposase [DNA replication, recombination, and repair]; Region: COG5421 526227007195 Fibronectin type III-like domain; Region: Fn3-like; cl15273 526227007196 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 526227007197 gamma-glutamyl kinase; Provisional; Region: PRK05429 526227007198 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 526227007199 nucleotide binding site [chemical binding]; other site 526227007200 homotetrameric interface [polypeptide binding]; other site 526227007201 putative phosphate binding site [ion binding]; other site 526227007202 putative allosteric binding site; other site 526227007203 PUA domain; Region: PUA; cl00607 526227007204 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 526227007205 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 526227007206 putative catalytic cysteine [active] 526227007207 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 526227007208 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 526227007209 NodB motif; other site 526227007210 active site 526227007211 catalytic site [active] 526227007212 metal binding site [ion binding]; metal-binding site 526227007213 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 526227007214 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 526227007215 core dimer interface [polypeptide binding]; other site 526227007216 peripheral dimer interface [polypeptide binding]; other site 526227007217 L10 interface [polypeptide binding]; other site 526227007218 L11 interface [polypeptide binding]; other site 526227007219 putative EF-Tu interaction site [polypeptide binding]; other site 526227007220 putative EF-G interaction site [polypeptide binding]; other site 526227007221 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 526227007222 23S rRNA interface [nucleotide binding]; other site 526227007223 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 526227007224 putative transposase OrfB; Reviewed; Region: PHA02517 526227007225 Integrase core domain; Region: rve; cl01316 526227007226 Integrase core domain; Region: rve_3; cl15866 526227007227 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 526227007228 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 526227007229 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 526227007230 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 526227007231 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 526227007232 BNR repeat-like domain; Region: BNR_2; pfam13088 526227007233 Predicted transcriptional regulator [Transcription]; Region: COG2378 526227007234 Helix-turn-helix domains; Region: HTH; cl00088 526227007235 WYL domain; Region: WYL; cl14852 526227007236 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 526227007237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227007238 NAD(P) binding site [chemical binding]; other site 526227007239 active site 526227007240 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 526227007241 mRNA/rRNA interface [nucleotide binding]; other site 526227007242 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 526227007243 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 526227007244 23S rRNA interface [nucleotide binding]; other site 526227007245 L7/L12 interface [polypeptide binding]; other site 526227007246 putative thiostrepton binding site; other site 526227007247 L25 interface [polypeptide binding]; other site 526227007248 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 526227007249 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 526227007250 putative homodimer interface [polypeptide binding]; other site 526227007251 KOW motif; Region: KOW; cl00354 526227007252 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 526227007253 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 526227007254 elongation factor Tu; Reviewed; Region: PRK00049 526227007255 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 526227007256 G1 box; other site 526227007257 GEF interaction site [polypeptide binding]; other site 526227007258 GTP/Mg2+ binding site [chemical binding]; other site 526227007259 Switch I region; other site 526227007260 G2 box; other site 526227007261 G3 box; other site 526227007262 Switch II region; other site 526227007263 G4 box; other site 526227007264 G5 box; other site 526227007265 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 526227007266 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 526227007267 Antibiotic Binding Site [chemical binding]; other site 526227007268 putative transposase OrfB; Reviewed; Region: PHA02517 526227007269 Integrase core domain; Region: rve; cl01316 526227007270 Integrase core domain; Region: rve_3; cl15866 526227007271 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 526227007272 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 526227007273 Beta-Casp domain; Region: Beta-Casp; cl12567 526227007274 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 526227007275 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 526227007276 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 526227007277 putative hydrophobic ligand binding site [chemical binding]; other site 526227007278 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 526227007279 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 526227007280 Ligand binding site; other site 526227007281 metal-binding site 526227007282 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 526227007283 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 526227007284 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 526227007285 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 526227007286 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 526227007287 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 526227007288 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 526227007289 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 526227007290 MoxR-like ATPases [General function prediction only]; Region: COG0714 526227007291 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 526227007292 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 526227007293 metal ion-dependent adhesion site (MIDAS); other site 526227007294 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 526227007295 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 526227007296 XdhC Rossmann domain; Region: XdhC_C; pfam13478 526227007297 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 526227007298 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 526227007299 GTP binding site; other site 526227007300 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 526227007301 Histidine kinase; Region: HisKA_3; pfam07730 526227007302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227007303 ATP binding site [chemical binding]; other site 526227007304 Mg2+ binding site [ion binding]; other site 526227007305 G-X-G motif; other site 526227007306 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 526227007307 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 526227007308 Transglycosylase; Region: Transgly; cl07896 526227007309 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 526227007310 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 526227007311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227007312 active site 526227007313 phosphorylation site [posttranslational modification] 526227007314 intermolecular recognition site; other site 526227007315 dimerization interface [polypeptide binding]; other site 526227007316 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227007317 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227007318 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227007319 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 526227007320 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 526227007321 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 526227007322 active site 526227007323 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 526227007324 active site 526227007325 dimer interface [polypeptide binding]; other site 526227007326 putative transposase OrfB; Reviewed; Region: PHA02517 526227007327 Integrase core domain; Region: rve; cl01316 526227007328 Integrase core domain; Region: rve_3; cl15866 526227007329 Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765 526227007330 Chain length determinant protein; Region: Wzz; cl15801 526227007331 Chain length determinant protein; Region: Wzz; cl15801 526227007332 OsmC-like protein; Region: OsmC; cl00767 526227007333 Sulfatase; Region: Sulfatase; cl10460 526227007334 putative transposase OrfB; Reviewed; Region: PHA02517 526227007335 Integrase core domain; Region: rve; cl01316 526227007336 Integrase core domain; Region: rve_3; cl15866 526227007337 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 526227007338 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227007339 Imelysin; Region: Peptidase_M75; cl09159 526227007340 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 526227007341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227007342 dimer interface [polypeptide binding]; other site 526227007343 conserved gate region; other site 526227007344 putative PBP binding loops; other site 526227007345 ABC-ATPase subunit interface; other site 526227007346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 526227007347 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 526227007348 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227007349 Walker A/P-loop; other site 526227007350 ATP binding site [chemical binding]; other site 526227007351 Q-loop/lid; other site 526227007352 ABC transporter signature motif; other site 526227007353 Walker B; other site 526227007354 D-loop; other site 526227007355 H-loop/switch region; other site 526227007356 TOBE domain; Region: TOBE_2; cl01440 526227007357 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 526227007358 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 526227007359 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 526227007360 dimerization interface 3.5A [polypeptide binding]; other site 526227007361 active site 526227007362 conserved hypothetical protein; Region: TIGR03492 526227007363 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 526227007364 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 526227007365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227007366 putative PBP binding loops; other site 526227007367 dimer interface [polypeptide binding]; other site 526227007368 ABC-ATPase subunit interface; other site 526227007369 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 526227007370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227007371 putative PBP binding loops; other site 526227007372 ABC-ATPase subunit interface; other site 526227007373 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 526227007374 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 526227007375 peptide binding site [polypeptide binding]; other site 526227007376 dimer interface [polypeptide binding]; other site 526227007377 putative transposase OrfB; Reviewed; Region: PHA02517 526227007378 Integrase core domain; Region: rve; cl01316 526227007379 Integrase core domain; Region: rve_3; cl15866 526227007380 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 526227007381 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 526227007382 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 526227007383 active site 526227007384 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 526227007385 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 526227007386 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 526227007387 active site 526227007388 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 526227007389 O-Antigen ligase; Region: Wzy_C; cl04850 526227007390 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 526227007391 Bacterial sugar transferase; Region: Bac_transf; cl00939 526227007392 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 526227007393 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 526227007394 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 526227007395 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526227007396 active site 526227007397 O-Antigen ligase; Region: Wzy_C; cl04850 526227007398 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 526227007399 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526227007400 active site 526227007401 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 526227007402 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 526227007403 Probable Catalytic site; other site 526227007404 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 526227007405 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227007406 UDP-galactopyranose mutase; Region: GLF; pfam03275 526227007407 MatE; Region: MatE; cl10513 526227007408 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 526227007409 active site 526227007410 NTP binding site [chemical binding]; other site 526227007411 metal binding triad [ion binding]; metal-binding site 526227007412 antibiotic binding site [chemical binding]; other site 526227007413 HEPN domain; Region: HEPN; cl00824 526227007414 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227007415 NAD(P) binding site [chemical binding]; other site 526227007416 active site 526227007417 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 526227007418 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 526227007419 thioester formation/cholesterol transfer; other site 526227007420 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 526227007421 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227007422 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 526227007423 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 526227007424 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227007425 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 526227007426 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 526227007427 NAD binding site [chemical binding]; other site 526227007428 substrate binding site [chemical binding]; other site 526227007429 homodimer interface [polypeptide binding]; other site 526227007430 active site 526227007431 Cupin domain; Region: Cupin_2; cl09118 526227007432 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227007433 NAD(P) binding site [chemical binding]; other site 526227007434 active site 526227007435 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 526227007436 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 526227007437 substrate binding site; other site 526227007438 metal-binding site 526227007439 Oligomer interface; other site 526227007440 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 526227007441 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 526227007442 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 526227007443 Substrate binding site; other site 526227007444 Cupin domain; Region: Cupin_2; cl09118 526227007445 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 526227007446 nudix motif; other site 526227007447 peptide chain release factor 1; Validated; Region: prfA; PRK00591 526227007448 RF-1 domain; Region: RF-1; cl02875 526227007449 RF-1 domain; Region: RF-1; cl02875 526227007450 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 526227007451 Helix-turn-helix domains; Region: HTH; cl00088 526227007452 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 526227007453 FeoA domain; Region: FeoA; cl00838 526227007454 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 526227007455 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 526227007456 putative transposase OrfB; Reviewed; Region: PHA02517 526227007457 Integrase core domain; Region: rve; cl01316 526227007458 Integrase core domain; Region: rve_3; cl15866 526227007459 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 526227007460 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 526227007461 Ligand Binding Site [chemical binding]; other site 526227007462 CrcB-like protein; Region: CRCB; cl09114 526227007463 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 526227007464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227007465 putative substrate translocation pore; other site 526227007466 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526227007467 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227007468 Walker A/P-loop; other site 526227007469 ATP binding site [chemical binding]; other site 526227007470 Q-loop/lid; other site 526227007471 ABC transporter signature motif; other site 526227007472 Walker B; other site 526227007473 D-loop; other site 526227007474 H-loop/switch region; other site 526227007475 The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also possess a conserved ATPase activity that...; Region: ABC_MutS_homologs; cd03243 526227007476 Walker A/P-loop; other site 526227007477 ATP binding site [chemical binding]; other site 526227007478 Q-loop/lid; other site 526227007479 ABC transporter signature motif; other site 526227007480 Walker B; other site 526227007481 D-loop; other site 526227007482 H-loop/switch region; other site 526227007483 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 526227007484 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 526227007485 Helix-turn-helix domains; Region: HTH; cl00088 526227007486 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 526227007487 putative dimerization interface [polypeptide binding]; other site 526227007488 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 526227007489 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 526227007490 putative anti-sigmaE protein; Provisional; Region: PRK13920 526227007491 Putative zinc-finger; Region: zf-HC2; cl15806 526227007492 Cupin domain; Region: Cupin_2; cl09118 526227007493 Cupin domain; Region: Cupin_2; cl09118 526227007494 Probable transposase; Region: OrfB_IS605; pfam01385 526227007495 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 526227007496 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 526227007497 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 526227007498 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 526227007499 sulfite oxidase; Provisional; Region: PLN00177 526227007500 Moco binding site; other site 526227007501 metal coordination site [ion binding]; other site 526227007502 Dihaem cytochrome c; Region: DHC; pfam09626 526227007503 Cytochrome c; Region: Cytochrom_C; cl11414 526227007504 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 526227007505 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 526227007506 GatB domain; Region: GatB_Yqey; cl11497 526227007507 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 526227007508 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 526227007509 dimerization interface [polypeptide binding]; other site 526227007510 putative ATP binding site [chemical binding]; other site 526227007511 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 526227007512 catalytic core [active] 526227007513 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 526227007514 classical (c) SDRs; Region: SDR_c; cd05233 526227007515 NAD(P) binding site [chemical binding]; other site 526227007516 active site 526227007517 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 526227007518 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 526227007519 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227007520 dimer interface [polypeptide binding]; other site 526227007521 conserved gate region; other site 526227007522 putative PBP binding loops; other site 526227007523 ABC-ATPase subunit interface; other site 526227007524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 526227007525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227007526 putative PBP binding loops; other site 526227007527 ABC-ATPase subunit interface; other site 526227007528 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 526227007529 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227007530 Transcriptional regulators [Transcription]; Region: PurR; COG1609 526227007531 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 526227007532 DNA binding site [nucleotide binding] 526227007533 domain linker motif; other site 526227007534 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 526227007535 ligand binding site [chemical binding]; other site 526227007536 dimerization interface [polypeptide binding]; other site 526227007537 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 526227007538 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 526227007539 substrate binding site; other site 526227007540 metal-binding site 526227007541 Oligomer interface; other site 526227007542 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 526227007543 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 526227007544 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 526227007545 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 526227007546 putative peptidoglycan binding site; other site 526227007547 Fibronectin type III-like domain; Region: Fn3-like; cl15273 526227007548 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227007549 Fibronectin type III-like domain; Region: Fn3-like; cl15273 526227007550 Fibronectin type III-like domain; Region: Fn3-like; cl15273 526227007551 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 526227007552 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 526227007553 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 526227007554 legume lectins; Region: lectin_L-type; cl14058 526227007555 homotetramer interaction site [polypeptide binding]; other site 526227007556 carbohydrate binding site [chemical binding]; other site 526227007557 metal binding site [ion binding]; metal-binding site 526227007558 Fibronectin type III-like domain; Region: Fn3-like; cl15273 526227007559 Fibronectin type III-like domain; Region: Fn3-like; cl15273 526227007560 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526227007561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227007562 active site 526227007563 phosphorylation site [posttranslational modification] 526227007564 intermolecular recognition site; other site 526227007565 dimerization interface [polypeptide binding]; other site 526227007566 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526227007567 DNA binding site [nucleotide binding] 526227007568 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 526227007569 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 526227007570 [2Fe-2S] cluster binding site [ion binding]; other site 526227007571 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 526227007572 hydrophobic ligand binding site; other site 526227007573 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 526227007574 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 526227007575 substrate binding pocket [chemical binding]; other site 526227007576 membrane-bound complex binding site; other site 526227007577 hinge residues; other site 526227007578 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 526227007579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227007580 dimer interface [polypeptide binding]; other site 526227007581 conserved gate region; other site 526227007582 putative PBP binding loops; other site 526227007583 ABC-ATPase subunit interface; other site 526227007584 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 526227007585 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 526227007586 Walker A/P-loop; other site 526227007587 ATP binding site [chemical binding]; other site 526227007588 Q-loop/lid; other site 526227007589 ABC transporter signature motif; other site 526227007590 Walker B; other site 526227007591 D-loop; other site 526227007592 H-loop/switch region; other site 526227007593 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 526227007594 heterotetramer interface [polypeptide binding]; other site 526227007595 active site pocket [active] 526227007596 cleavage site 526227007597 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 526227007598 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 526227007599 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 526227007600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227007601 ornithine carbamoyltransferase; Provisional; Region: PRK00779 526227007602 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 526227007603 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227007604 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 526227007605 Helix-turn-helix domains; Region: HTH; cl00088 526227007606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227007607 putative substrate translocation pore; other site 526227007608 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 526227007609 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 526227007610 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 526227007611 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 526227007612 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 526227007613 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 526227007614 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 526227007615 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227007616 Walker A/P-loop; other site 526227007617 ATP binding site [chemical binding]; other site 526227007618 Q-loop/lid; other site 526227007619 ABC transporter signature motif; other site 526227007620 Walker B; other site 526227007621 D-loop; other site 526227007622 H-loop/switch region; other site 526227007623 glycerol-3-phosphate dehydrogenase; Region: PLN02464 526227007624 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 526227007625 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 526227007626 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227007627 binding surface 526227007628 TPR motif; other site 526227007629 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 526227007630 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 526227007631 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 526227007632 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 526227007633 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 526227007634 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 526227007635 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 526227007636 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 526227007637 Active site serine [active] 526227007638 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 526227007639 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 526227007640 protein binding site [polypeptide binding]; other site 526227007641 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 526227007642 Active site serine [active] 526227007643 Stage II sporulation protein; Region: SpoIID; pfam08486 526227007644 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 526227007645 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 526227007646 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 526227007647 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 526227007648 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 526227007649 ligand binding site [chemical binding]; other site 526227007650 flexible hinge region; other site 526227007651 Helix-turn-helix domains; Region: HTH; cl00088 526227007652 NMT1-like family; Region: NMT1_2; cl15260 526227007653 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 526227007654 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 526227007655 Catalytic site [active] 526227007656 Cytochrome c; Region: Cytochrom_C; cl11414 526227007657 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 526227007658 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 526227007659 dimer interface [polypeptide binding]; other site 526227007660 ssDNA binding site [nucleotide binding]; other site 526227007661 tetramer (dimer of dimers) interface [polypeptide binding]; other site 526227007662 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 526227007663 dimer interface [polypeptide binding]; other site 526227007664 ssDNA binding site [nucleotide binding]; other site 526227007665 tetramer (dimer of dimers) interface [polypeptide binding]; other site 526227007666 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 526227007667 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526227007668 ATP binding site [chemical binding]; other site 526227007669 putative Mg++ binding site [ion binding]; other site 526227007670 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526227007671 nucleotide binding region [chemical binding]; other site 526227007672 ATP-binding site [chemical binding]; other site 526227007673 Helicase associated domain (HA2); Region: HA2; cl04503 526227007674 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 526227007675 CAAX protease self-immunity; Region: Abi; cl00558 526227007676 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 526227007677 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526227007678 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 526227007679 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526227007680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227007681 active site 526227007682 phosphorylation site [posttranslational modification] 526227007683 intermolecular recognition site; other site 526227007684 dimerization interface [polypeptide binding]; other site 526227007685 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526227007686 DNA binding residues [nucleotide binding] 526227007687 dimerization interface [polypeptide binding]; other site 526227007688 PAS domain S-box; Region: sensory_box; TIGR00229 526227007689 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 526227007690 putative active site [active] 526227007691 heme pocket [chemical binding]; other site 526227007692 GAF domain; Region: GAF; cl15785 526227007693 GAF domain; Region: GAF_2; pfam13185 526227007694 GAF domain; Region: GAF; cl15785 526227007695 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 526227007696 Histidine kinase; Region: HisKA_3; pfam07730 526227007697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227007698 ATP binding site [chemical binding]; other site 526227007699 Mg2+ binding site [ion binding]; other site 526227007700 G-X-G motif; other site 526227007701 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 526227007702 Helix-turn-helix domains; Region: HTH; cl00088 526227007703 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 526227007704 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 526227007705 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 526227007706 Walker A/P-loop; other site 526227007707 ATP binding site [chemical binding]; other site 526227007708 Q-loop/lid; other site 526227007709 ABC transporter signature motif; other site 526227007710 Walker B; other site 526227007711 D-loop; other site 526227007712 H-loop/switch region; other site 526227007713 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 526227007714 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 526227007715 TM-ABC transporter signature motif; other site 526227007716 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 526227007717 TM-ABC transporter signature motif; other site 526227007718 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 526227007719 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 526227007720 ligand binding site [chemical binding]; other site 526227007721 Anabaena sensory rhodopsin transducer; Region: ASRT; cl01751 526227007722 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 526227007723 short chain dehydrogenase; Validated; Region: PRK08324 526227007724 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 526227007725 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 526227007726 putative NAD(P) binding site [chemical binding]; other site 526227007727 active site 526227007728 L-rhamnulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 526227007729 N- and C-terminal domain interface [polypeptide binding]; other site 526227007730 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 526227007731 active site 526227007732 catalytic site [active] 526227007733 metal binding site [ion binding]; metal-binding site 526227007734 ATP binding site [chemical binding]; other site 526227007735 carbohydrate binding site [chemical binding]; other site 526227007736 DDE superfamily endonuclease; Region: DDE_4; cl15789 526227007737 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227007738 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 526227007739 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 526227007740 Transcriptional regulators [Transcription]; Region: MarR; COG1846 526227007741 Helix-turn-helix domains; Region: HTH; cl00088 526227007742 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 526227007743 heme-binding site [chemical binding]; other site 526227007744 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 526227007745 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 526227007746 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 526227007747 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 526227007748 active site 526227007749 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 526227007750 phosphopeptide binding site; other site 526227007751 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 526227007752 Protein kinase domain; Region: Pkinase; pfam00069 526227007753 Catalytic domain of Protein Kinases; Region: PKc; cd00180 526227007754 active site 526227007755 ATP binding site [chemical binding]; other site 526227007756 substrate binding site [chemical binding]; other site 526227007757 activation loop (A-loop); other site 526227007758 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 526227007759 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 526227007760 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 526227007761 metal ion-dependent adhesion site (MIDAS); other site 526227007762 putative transposase OrfB; Reviewed; Region: PHA02517 526227007763 Integrase core domain; Region: rve; cl01316 526227007764 Integrase core domain; Region: rve_3; cl15866 526227007765 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 526227007766 nucleotide binding site [chemical binding]; other site 526227007767 N-acetyl-L-glutamate binding site [chemical binding]; other site 526227007768 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 526227007769 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266 526227007770 putative NAD(P) binding site [chemical binding]; other site 526227007771 structural Zn binding site [ion binding]; other site 526227007772 LabA_like proteins; Region: LabA_like/DUF88; cl10034 526227007773 putative metal binding site [ion binding]; other site 526227007774 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381 526227007775 Protein of unknown function (DUF402); Region: DUF402; cl00979 526227007776 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 526227007777 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 526227007778 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 526227007779 alphaNTD - beta interaction site [polypeptide binding]; other site 526227007780 alphaNTD homodimer interface [polypeptide binding]; other site 526227007781 alphaNTD - beta' interaction site [polypeptide binding]; other site 526227007782 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 526227007783 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 526227007784 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 526227007785 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 526227007786 RNA binding surface [nucleotide binding]; other site 526227007787 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 526227007788 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 526227007789 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 526227007790 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 526227007791 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 526227007792 rRNA binding site [nucleotide binding]; other site 526227007793 predicted 30S ribosome binding site; other site 526227007794 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 526227007795 active site 526227007796 adenylate kinase; Provisional; Region: PRK14527 526227007797 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 526227007798 AMP-binding site [chemical binding]; other site 526227007799 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 526227007800 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 526227007801 SecY translocase; Region: SecY; pfam00344 526227007802 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 526227007803 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 526227007804 23S rRNA binding site [nucleotide binding]; other site 526227007805 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 526227007806 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 526227007807 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 526227007808 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 526227007809 5S rRNA interface [nucleotide binding]; other site 526227007810 23S rRNA interface [nucleotide binding]; other site 526227007811 L5 interface [polypeptide binding]; other site 526227007812 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 526227007813 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 526227007814 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 526227007815 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 526227007816 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 526227007817 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 526227007818 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 526227007819 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 526227007820 KOW motif; Region: KOW; cl00354 526227007821 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 526227007822 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 526227007823 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 526227007824 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 526227007825 23S rRNA interface [nucleotide binding]; other site 526227007826 putative translocon interaction site; other site 526227007827 signal recognition particle (SRP54) interaction site; other site 526227007828 L23 interface [polypeptide binding]; other site 526227007829 trigger factor interaction site; other site 526227007830 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 526227007831 23S rRNA interface [nucleotide binding]; other site 526227007832 5S rRNA interface [nucleotide binding]; other site 526227007833 putative antibiotic binding site [chemical binding]; other site 526227007834 L25 interface [polypeptide binding]; other site 526227007835 L27 interface [polypeptide binding]; other site 526227007836 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 526227007837 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 526227007838 G-X-X-G motif; other site 526227007839 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 526227007840 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 526227007841 putative translocon binding site; other site 526227007842 protein-rRNA interface [nucleotide binding]; other site 526227007843 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 526227007844 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 526227007845 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 526227007846 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 526227007847 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 526227007848 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 526227007849 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 526227007850 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 526227007851 elongation factor Tu; Reviewed; Region: PRK00049 526227007852 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 526227007853 G1 box; other site 526227007854 GEF interaction site [polypeptide binding]; other site 526227007855 GTP/Mg2+ binding site [chemical binding]; other site 526227007856 Switch I region; other site 526227007857 G2 box; other site 526227007858 G3 box; other site 526227007859 Switch II region; other site 526227007860 G4 box; other site 526227007861 G5 box; other site 526227007862 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 526227007863 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 526227007864 Antibiotic Binding Site [chemical binding]; other site 526227007865 elongation factor G; Reviewed; Region: PRK00007 526227007866 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 526227007867 G1 box; other site 526227007868 putative GEF interaction site [polypeptide binding]; other site 526227007869 GTP/Mg2+ binding site [chemical binding]; other site 526227007870 Switch I region; other site 526227007871 G2 box; other site 526227007872 G3 box; other site 526227007873 Switch II region; other site 526227007874 G4 box; other site 526227007875 G5 box; other site 526227007876 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 526227007877 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 526227007878 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 526227007879 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 526227007880 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 526227007881 S17 interaction site [polypeptide binding]; other site 526227007882 S8 interaction site; other site 526227007883 16S rRNA interaction site [nucleotide binding]; other site 526227007884 streptomycin interaction site [chemical binding]; other site 526227007885 23S rRNA interaction site [nucleotide binding]; other site 526227007886 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 526227007887 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227007888 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227007889 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227007890 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 526227007891 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 526227007892 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 526227007893 Cu(I) binding site [ion binding]; other site 526227007894 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333 526227007895 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 526227007896 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 526227007897 putative active site [active] 526227007898 putative CoA binding site [chemical binding]; other site 526227007899 nudix motif; other site 526227007900 metal binding site [ion binding]; metal-binding site 526227007901 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 526227007902 intracellular protease, PfpI family; Region: PfpI; TIGR01382 526227007903 proposed catalytic triad [active] 526227007904 conserved cys residue [active] 526227007905 putative aminotransferase; Validated; Region: PRK07480 526227007906 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 526227007907 inhibitor-cofactor binding pocket; inhibition site 526227007908 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227007909 catalytic residue [active] 526227007910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227007911 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526227007912 putative substrate translocation pore; other site 526227007913 Helix-turn-helix domains; Region: HTH; cl00088 526227007914 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 526227007915 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 526227007916 sequence-specific DNA binding site [nucleotide binding]; other site 526227007917 salt bridge; other site 526227007918 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 526227007919 Domain of unknown function (DUF955); Region: DUF955; cl01076 526227007920 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_37; cd04696 526227007921 nudix motif; other site 526227007922 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 526227007923 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227007924 NAD(P) binding site [chemical binding]; other site 526227007925 active site 526227007926 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 526227007927 homodecamer interface [polypeptide binding]; other site 526227007928 GTP cyclohydrolase I; Provisional; Region: PLN03044 526227007929 active site 526227007930 putative catalytic site residues [active] 526227007931 zinc binding site [ion binding]; other site 526227007932 GTP-CH-I/GFRP interaction surface; other site 526227007933 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 526227007934 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 526227007935 Ligand binding site; other site 526227007936 Putative Catalytic site; other site 526227007937 DXD motif; other site 526227007938 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 526227007939 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 526227007940 Probable Catalytic site; other site 526227007941 metal-binding site 526227007942 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526227007943 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 526227007944 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 526227007945 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 526227007946 DXD motif; other site 526227007947 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526227007948 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526227007949 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 526227007950 Cupin domain; Region: Cupin_2; cl09118 526227007951 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 526227007952 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 526227007953 inhibitor-cofactor binding pocket; inhibition site 526227007954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227007955 catalytic residue [active] 526227007956 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 526227007957 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 526227007958 active site 526227007959 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 526227007960 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 526227007961 substrate binding site; other site 526227007962 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 526227007963 extended (e) SDRs; Region: SDR_e; cd08946 526227007964 NAD(P) binding site [chemical binding]; other site 526227007965 active site 526227007966 substrate binding site [chemical binding]; other site 526227007967 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 526227007968 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 526227007969 Methyltransferase domain; Region: Methyltransf_31; pfam13847 526227007970 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 526227007971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 526227007972 Protein of unknown function (DUF3379); Region: DUF3379; pfam11859 526227007973 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 526227007974 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 526227007975 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526227007976 active site 526227007977 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 526227007978 MatE; Region: MatE; cl10513 526227007979 MatE; Region: MatE; cl10513 526227007980 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 526227007981 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526227007982 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 526227007983 active site 526227007984 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 526227007985 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526227007986 active site 526227007987 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 526227007988 Helix-turn-helix domains; Region: HTH; cl00088 526227007989 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 526227007990 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 526227007991 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526227007992 catalytic residue [active] 526227007993 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 526227007994 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 526227007995 NAD binding site [chemical binding]; other site 526227007996 homodimer interface [polypeptide binding]; other site 526227007997 active site 526227007998 putative substrate binding site [chemical binding]; other site 526227007999 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 526227008000 intersubunit interface [polypeptide binding]; other site 526227008001 active site 526227008002 catalytic residue [active] 526227008003 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 526227008004 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 526227008005 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227008006 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 526227008007 putative transposase OrfB; Reviewed; Region: PHA02517 526227008008 Integrase core domain; Region: rve; cl01316 526227008009 Integrase core domain; Region: rve_3; cl15866 526227008010 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 526227008011 conserved cys residue [active] 526227008012 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 526227008013 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227008014 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 526227008015 CAAX protease self-immunity; Region: Abi; cl00558 526227008016 Protein of unknown function (DUF1616); Region: DUF1616; cl01959 526227008017 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 526227008018 putative active site [active] 526227008019 Helix-turn-helix domains; Region: HTH; cl00088 526227008020 cytidylate kinase, putative; Region: cyt_kin_arch; TIGR02173 526227008021 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227008022 Predicted ATPase [General function prediction only]; Region: COG3899 526227008023 Helix-turn-helix domains; Region: HTH; cl00088 526227008024 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 526227008025 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 526227008026 Predicted transcriptional regulators [Transcription]; Region: COG1510 526227008027 Response regulator receiver domain; Region: Response_reg; pfam00072 526227008028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227008029 active site 526227008030 phosphorylation site [posttranslational modification] 526227008031 intermolecular recognition site; other site 526227008032 dimerization interface [polypeptide binding]; other site 526227008033 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 526227008034 active site 526227008035 catalytic residues [active] 526227008036 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227008037 Response regulator receiver domain; Region: Response_reg; pfam00072 526227008038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227008039 active site 526227008040 phosphorylation site [posttranslational modification] 526227008041 intermolecular recognition site; other site 526227008042 dimerization interface [polypeptide binding]; other site 526227008043 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 526227008044 heme pocket [chemical binding]; other site 526227008045 putative active site [active] 526227008046 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 526227008047 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526227008048 dimer interface [polypeptide binding]; other site 526227008049 phosphorylation site [posttranslational modification] 526227008050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227008051 ATP binding site [chemical binding]; other site 526227008052 Mg2+ binding site [ion binding]; other site 526227008053 G-X-G motif; other site 526227008054 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 526227008055 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 526227008056 inhibitor-cofactor binding pocket; inhibition site 526227008057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227008058 catalytic residue [active] 526227008059 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227008060 NAD(P) binding pocket [chemical binding]; other site 526227008061 porphobilinogen deaminase; Region: hemC; TIGR00212 526227008062 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 526227008063 domain interfaces; other site 526227008064 active site 526227008065 Porphobilinogen deaminase, C-terminal domain; Region: Porphobil_deamC; pfam03900 526227008066 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 526227008067 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 526227008068 active site 526227008069 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 526227008070 dimer interface [polypeptide binding]; other site 526227008071 active site 526227008072 Schiff base residues; other site 526227008073 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 526227008074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227008075 ATP binding site [chemical binding]; other site 526227008076 Mg2+ binding site [ion binding]; other site 526227008077 G-X-G motif; other site 526227008078 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526227008079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227008080 active site 526227008081 phosphorylation site [posttranslational modification] 526227008082 intermolecular recognition site; other site 526227008083 dimerization interface [polypeptide binding]; other site 526227008084 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526227008085 DNA binding site [nucleotide binding] 526227008086 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 526227008087 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 526227008088 substrate binding site [chemical binding]; other site 526227008089 active site 526227008090 Chlorite dismutase; Region: Chlor_dismutase; cl01280 526227008091 ferrochelatase; Reviewed; Region: hemH; PRK00035 526227008092 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 526227008093 C-terminal domain interface [polypeptide binding]; other site 526227008094 active site 526227008095 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 526227008096 active site 526227008097 N-terminal domain interface [polypeptide binding]; other site 526227008098 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 526227008099 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227008100 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 526227008101 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 526227008102 FtsX-like permease family; Region: FtsX; cl15850 526227008103 3D domain; Region: 3D; cl01439 526227008104 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 526227008105 DAK2 domain; Region: Dak2; cl03685 526227008106 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 526227008107 Asp23 family; Region: Asp23; cl00574 526227008108 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 526227008109 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 526227008110 CrcB-like protein; Region: CRCB; cl09114 526227008111 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 526227008112 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 526227008113 Moco binding site; other site 526227008114 metal coordination site [ion binding]; other site 526227008115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 526227008116 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 526227008117 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 526227008118 VanW like protein; Region: VanW; pfam04294 526227008119 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 526227008120 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 526227008121 active site 526227008122 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 526227008123 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 526227008124 RNA binding surface [nucleotide binding]; other site 526227008125 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 526227008126 active site 526227008127 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 526227008128 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 526227008129 substrate binding site [chemical binding]; other site 526227008130 oxyanion hole (OAH) forming residues; other site 526227008131 trimer interface [polypeptide binding]; other site 526227008132 tRNA pseudouridine synthase B; Provisional; Region: PRK14122 526227008133 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 526227008134 RNA binding site [nucleotide binding]; other site 526227008135 active site 526227008136 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 526227008137 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 526227008138 Helix-turn-helix domains; Region: HTH; cl00088 526227008139 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 526227008140 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 526227008141 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227008142 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 526227008143 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 526227008144 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 526227008145 Domain of unknown function DUF20; Region: UPF0118; pfam01594 526227008146 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 526227008147 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 526227008148 Peptidase family M23; Region: Peptidase_M23; pfam01551 526227008149 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 526227008150 putative transposase OrfB; Reviewed; Region: PHA02517 526227008151 Integrase core domain; Region: rve; cl01316 526227008152 Integrase core domain; Region: rve_3; cl15866 526227008153 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 526227008154 aspartate aminotransferase; Provisional; Region: PRK05764 526227008155 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 526227008156 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227008157 homodimer interface [polypeptide binding]; other site 526227008158 catalytic residue [active] 526227008159 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 526227008160 L-asparaginase II; Region: Asparaginase_II; cl01842 526227008161 Domain of unknown function (DUF309); Region: DUF309; cl00667 526227008162 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 526227008163 catalytic residues [active] 526227008164 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 526227008165 Mechanosensitive ion channel; Region: MS_channel; pfam00924 526227008166 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227008167 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 526227008168 Carboxylesterase family; Region: COesterase; pfam00135 526227008169 substrate binding pocket [chemical binding]; other site 526227008170 catalytic triad [active] 526227008171 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 526227008172 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 526227008173 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 526227008174 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 526227008175 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 526227008176 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 526227008177 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 526227008178 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 526227008179 active site 526227008180 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 526227008181 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 526227008182 Active_site [active] 526227008183 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 526227008184 MoxR-like ATPases [General function prediction only]; Region: COG0714 526227008185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227008186 Walker A motif; other site 526227008187 ATP binding site [chemical binding]; other site 526227008188 Walker B motif; other site 526227008189 arginine finger; other site 526227008190 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 526227008191 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 526227008192 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 526227008193 metal ion-dependent adhesion site (MIDAS); other site 526227008194 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 526227008195 metal ion-dependent adhesion site (MIDAS); other site 526227008196 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 526227008197 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 526227008198 Domain of unknown function DUF59; Region: DUF59; cl00941 526227008199 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 526227008200 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 526227008201 Phenylacetic acid degradation B; Region: PaaB; cl01371 526227008202 Phenylacetic acid degradation B; Region: PaaB; cl01371 526227008203 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 526227008204 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 526227008205 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526227008206 Coenzyme A binding pocket [chemical binding]; other site 526227008207 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 526227008208 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 526227008209 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 526227008210 active site 526227008211 metal binding site [ion binding]; metal-binding site 526227008212 Helix-turn-helix domains; Region: HTH; cl00088 526227008213 putative transposase OrfB; Reviewed; Region: PHA02517 526227008214 Integrase core domain; Region: rve; cl01316 526227008215 Integrase core domain; Region: rve_3; cl15866 526227008216 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 526227008217 uncharacterized xylulose kinase-like proteins, subgroup 1; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 526227008218 N- and C-terminal domain interface [polypeptide binding]; other site 526227008219 putative active site [active] 526227008220 catalytic site [active] 526227008221 metal binding site [ion binding]; metal-binding site 526227008222 putative xylulose binding site [chemical binding]; other site 526227008223 putative ATP binding site [chemical binding]; other site 526227008224 putative homodimer interface [polypeptide binding]; other site 526227008225 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 526227008226 N- and C-terminal domain interface [polypeptide binding]; other site 526227008227 D-xylulose kinase; Region: XylB; TIGR01312 526227008228 active site 526227008229 catalytic site [active] 526227008230 metal binding site [ion binding]; metal-binding site 526227008231 xylulose binding site [chemical binding]; other site 526227008232 putative ATP binding site [chemical binding]; other site 526227008233 homodimer interface [polypeptide binding]; other site 526227008234 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 526227008235 Helix-turn-helix domains; Region: HTH; cl00088 526227008236 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 526227008237 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 526227008238 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 526227008239 NAD(P) binding site [chemical binding]; other site 526227008240 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 526227008241 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227008242 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 526227008243 tetramer interface [polypeptide binding]; other site 526227008244 Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane]; Region: GutQ; COG0794 526227008245 active site 526227008246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227008247 dimer interface [polypeptide binding]; other site 526227008248 conserved gate region; other site 526227008249 putative PBP binding loops; other site 526227008250 ABC-ATPase subunit interface; other site 526227008251 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 526227008252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227008253 dimer interface [polypeptide binding]; other site 526227008254 conserved gate region; other site 526227008255 ABC-ATPase subunit interface; other site 526227008256 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 526227008257 AP (apurinic/apyrimidinic) site pocket; other site 526227008258 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 526227008259 DNA interaction; other site 526227008260 Metal-binding active site; metal-binding site 526227008261 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526227008262 MULE transposase domain; Region: MULE; pfam10551 526227008263 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 526227008264 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 526227008265 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 526227008266 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 526227008267 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 526227008268 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 526227008269 N- and C-terminal domain interface [polypeptide binding]; other site 526227008270 D-xylulose kinase; Region: XylB; TIGR01312 526227008271 active site 526227008272 catalytic site [active] 526227008273 metal binding site [ion binding]; metal-binding site 526227008274 xylulose binding site [chemical binding]; other site 526227008275 putative ATP binding site [chemical binding]; other site 526227008276 homodimer interface [polypeptide binding]; other site 526227008277 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 526227008278 Moco binding site; other site 526227008279 metal coordination site [ion binding]; other site 526227008280 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 526227008281 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 526227008282 ABC-2 type transporter; Region: ABC2_membrane; cl11417 526227008283 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 526227008284 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227008285 Walker A/P-loop; other site 526227008286 ATP binding site [chemical binding]; other site 526227008287 Q-loop/lid; other site 526227008288 ABC transporter signature motif; other site 526227008289 Walker B; other site 526227008290 D-loop; other site 526227008291 H-loop/switch region; other site 526227008292 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526227008293 Helix-turn-helix domains; Region: HTH; cl00088 526227008294 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 526227008295 putative FMN binding site [chemical binding]; other site 526227008296 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 526227008297 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 526227008298 peptide binding site [polypeptide binding]; other site 526227008299 dimer interface [polypeptide binding]; other site 526227008300 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 526227008301 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 526227008302 Walker A/P-loop; other site 526227008303 ATP binding site [chemical binding]; other site 526227008304 Q-loop/lid; other site 526227008305 ABC transporter signature motif; other site 526227008306 Walker B; other site 526227008307 D-loop; other site 526227008308 H-loop/switch region; other site 526227008309 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 526227008310 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 526227008311 ABC-ATPase subunit interface; other site 526227008312 dimer interface [polypeptide binding]; other site 526227008313 putative PBP binding regions; other site 526227008314 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 526227008315 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 526227008316 putative binding site residues; other site 526227008317 putative transposase OrfB; Reviewed; Region: PHA02517 526227008318 Integrase core domain; Region: rve; cl01316 526227008319 Integrase core domain; Region: rve_3; cl15866 526227008320 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 526227008321 proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 526227008322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227008323 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 526227008324 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 526227008325 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 526227008326 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 526227008327 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 526227008328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227008329 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 526227008330 putative active site pocket [active] 526227008331 cleavage site 526227008332 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; cl01017 526227008333 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 526227008334 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 526227008335 Probable transposase; Region: OrfB_IS605; pfam01385 526227008336 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 526227008337 putative transposase OrfB; Reviewed; Region: PHA02517 526227008338 Integrase core domain; Region: rve; cl01316 526227008339 Integrase core domain; Region: rve_3; cl15866 526227008340 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526227008341 Helix-turn-helix domains; Region: HTH; cl00088 526227008342 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 526227008343 replicative DNA helicase; Region: DnaB; TIGR00665 526227008344 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 526227008345 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 526227008346 Walker A motif; other site 526227008347 ATP binding site [chemical binding]; other site 526227008348 Walker B motif; other site 526227008349 DNA binding loops [nucleotide binding] 526227008350 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227008351 binding surface 526227008352 TPR motif; other site 526227008353 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 526227008354 TPR repeat; Region: TPR_11; pfam13414 526227008355 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227008356 binding surface 526227008357 TPR motif; other site 526227008358 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 526227008359 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 526227008360 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 526227008361 dimer interface [polypeptide binding]; other site 526227008362 motif 1; other site 526227008363 active site 526227008364 motif 2; other site 526227008365 motif 3; other site 526227008366 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 526227008367 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 526227008368 putative tRNA-binding site [nucleotide binding]; other site 526227008369 B3/4 domain; Region: B3_4; cl11458 526227008370 tRNA synthetase B5 domain; Region: B5; cl08394 526227008371 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 526227008372 dimer interface [polypeptide binding]; other site 526227008373 motif 1; other site 526227008374 motif 3; other site 526227008375 motif 2; other site 526227008376 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 526227008377 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 526227008378 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 526227008379 active site 526227008380 ADP/pyrophosphate binding site [chemical binding]; other site 526227008381 dimerization interface [polypeptide binding]; other site 526227008382 allosteric effector site; other site 526227008383 fructose-1,6-bisphosphate binding site; other site 526227008384 Predicted methyltransferases [General function prediction only]; Region: COG0313 526227008385 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 526227008386 putative transposase OrfB; Reviewed; Region: PHA02517 526227008387 Integrase core domain; Region: rve; cl01316 526227008388 Integrase core domain; Region: rve_3; cl15866 526227008389 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526227008390 MULE transposase domain; Region: MULE; pfam10551 526227008391 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 526227008392 active site 526227008393 Ap6A binding site [chemical binding]; other site 526227008394 nudix motif; other site 526227008395 metal binding site [ion binding]; metal-binding site 526227008396 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 526227008397 ArgK protein; Region: ArgK; pfam03308 526227008398 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 526227008399 Walker A; other site 526227008400 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 526227008401 homotrimer interaction site [polypeptide binding]; other site 526227008402 putative active site [active] 526227008403 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 526227008404 active site 526227008405 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 526227008406 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 526227008407 dimer interface [polypeptide binding]; other site 526227008408 TPP-binding site [chemical binding]; other site 526227008409 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 526227008410 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 526227008411 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 526227008412 E3 interaction surface; other site 526227008413 lipoyl attachment site [posttranslational modification]; other site 526227008414 e3 binding domain; Region: E3_binding; pfam02817 526227008415 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 526227008416 arginine decarboxylase; Provisional; Region: PRK05354 526227008417 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 526227008418 dimer interface [polypeptide binding]; other site 526227008419 active site 526227008420 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 526227008421 catalytic residues [active] 526227008422 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 526227008423 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526227008424 metal binding site [ion binding]; metal-binding site 526227008425 active site 526227008426 I-site; other site 526227008427 S-adenosylmethionine synthetase; Validated; Region: PRK05250 526227008428 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 526227008429 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 526227008430 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 526227008431 GAF domain; Region: GAF_2; pfam13185 526227008432 GAF domain; Region: GAF; cl15785 526227008433 GAF domain; Region: GAF_2; pfam13185 526227008434 GAF domain; Region: GAF; cl15785 526227008435 GAF domain; Region: GAF_2; pfam13185 526227008436 GAF domain; Region: GAF; cl15785 526227008437 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 526227008438 Zn2+ binding site [ion binding]; other site 526227008439 Mg2+ binding site [ion binding]; other site 526227008440 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 526227008441 Protein of unknown function (DUF4127); Region: DUF4127; pfam13552 526227008442 Transcriptional regulators [Transcription]; Region: GntR; COG1802 526227008443 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 526227008444 DNA-binding site [nucleotide binding]; DNA binding site 526227008445 FCD domain; Region: FCD; cl11656 526227008446 Proline dehydrogenase; Region: Pro_dh; cl03282 526227008447 Uncharacterized conserved protein [Function unknown]; Region: COG3603 526227008448 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 526227008449 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 526227008450 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 526227008451 Glutamate binding site [chemical binding]; other site 526227008452 homodimer interface [polypeptide binding]; other site 526227008453 NAD binding site [chemical binding]; other site 526227008454 catalytic residues [active] 526227008455 DDE superfamily endonuclease; Region: DDE_4; cl15789 526227008456 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227008457 Predicted membrane protein [Function unknown]; Region: COG4280 526227008458 Protein of unknown function (DUF1634); Region: DUF1634; cl01741 526227008459 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 526227008460 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 526227008461 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 526227008462 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 526227008463 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 526227008464 Domain interface; other site 526227008465 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 526227008466 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 526227008467 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 526227008468 iron-sulfur cluster [ion binding]; other site 526227008469 [2Fe-2S] cluster binding site [ion binding]; other site 526227008470 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 526227008471 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 526227008472 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526227008473 dimer interface [polypeptide binding]; other site 526227008474 phosphorylation site [posttranslational modification] 526227008475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227008476 ATP binding site [chemical binding]; other site 526227008477 Mg2+ binding site [ion binding]; other site 526227008478 G-X-G motif; other site 526227008479 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526227008480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227008481 active site 526227008482 phosphorylation site [posttranslational modification] 526227008483 intermolecular recognition site; other site 526227008484 dimerization interface [polypeptide binding]; other site 526227008485 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526227008486 DNA binding site [nucleotide binding] 526227008487 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 526227008488 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526227008489 dimer interface [polypeptide binding]; other site 526227008490 phosphorylation site [posttranslational modification] 526227008491 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227008492 ATP binding site [chemical binding]; other site 526227008493 G-X-G motif; other site 526227008494 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526227008495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227008496 active site 526227008497 phosphorylation site [posttranslational modification] 526227008498 intermolecular recognition site; other site 526227008499 dimerization interface [polypeptide binding]; other site 526227008500 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526227008501 DNA binding site [nucleotide binding] 526227008502 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 526227008503 active site 526227008504 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 526227008505 Uncharacterized conserved protein [Function unknown]; Region: COG3391 526227008506 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 526227008507 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 526227008508 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 526227008509 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 526227008510 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 526227008511 homodimer interface [polypeptide binding]; other site 526227008512 substrate-cofactor binding pocket; other site 526227008513 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227008514 catalytic residue [active] 526227008515 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 526227008516 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 526227008517 active site 526227008518 dimer interface [polypeptide binding]; other site 526227008519 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 526227008520 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 526227008521 Walker A/P-loop; other site 526227008522 ATP binding site [chemical binding]; other site 526227008523 Q-loop/lid; other site 526227008524 ABC transporter signature motif; other site 526227008525 Walker B; other site 526227008526 D-loop; other site 526227008527 H-loop/switch region; other site 526227008528 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 526227008529 DDE superfamily endonuclease; Region: DDE_4; cl15789 526227008530 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227008531 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 526227008532 amphipathic channel; other site 526227008533 Asn-Pro-Ala signature motifs; other site 526227008534 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 526227008535 Fe-S cluster binding site [ion binding]; other site 526227008536 DNA binding site [nucleotide binding] 526227008537 active site 526227008538 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 526227008539 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 526227008540 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 526227008541 putative transposase OrfB; Reviewed; Region: PHA02517 526227008542 Integrase core domain; Region: rve; cl01316 526227008543 Integrase core domain; Region: rve_3; cl15866 526227008544 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227008545 S-adenosylmethionine binding site [chemical binding]; other site 526227008546 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 526227008547 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 526227008548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227008549 homodimer interface [polypeptide binding]; other site 526227008550 catalytic residue [active] 526227008551 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 526227008552 active site residue [active] 526227008553 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 526227008554 active site residue [active] 526227008555 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 526227008556 Transposase [DNA replication, recombination, and repair]; Region: COG5421 526227008557 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 526227008558 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 526227008559 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 526227008560 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 526227008561 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526227008562 motif II; other site 526227008563 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 526227008564 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 526227008565 Ligand Binding Site [chemical binding]; other site 526227008566 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 526227008567 Ligand Binding Site [chemical binding]; other site 526227008568 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 526227008569 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 526227008570 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 526227008571 MPT binding site; other site 526227008572 trimer interface [polypeptide binding]; other site 526227008573 Transcriptional regulators [Transcription]; Region: PurR; COG1609 526227008574 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 526227008575 DNA binding site [nucleotide binding] 526227008576 domain linker motif; other site 526227008577 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 526227008578 dimerization interface [polypeptide binding]; other site 526227008579 ligand binding site [chemical binding]; other site 526227008580 alpha-galactosidase; Provisional; Region: PRK15076 526227008581 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 526227008582 NAD binding site [chemical binding]; other site 526227008583 sugar binding site [chemical binding]; other site 526227008584 divalent metal binding site [ion binding]; other site 526227008585 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 526227008586 dimer interface [polypeptide binding]; other site 526227008587 putative transposase OrfB; Reviewed; Region: PHA02517 526227008588 Integrase core domain; Region: rve; cl01316 526227008589 Integrase core domain; Region: rve_3; cl15866 526227008590 succinyldiaminopimelate transaminase; Validated; Region: PRK07366 526227008591 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 526227008592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227008593 homodimer interface [polypeptide binding]; other site 526227008594 catalytic residue [active] 526227008595 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526227008596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227008597 putative substrate translocation pore; other site 526227008598 HicB family; Region: HicB; pfam05534 526227008599 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 526227008600 putative active site [active] 526227008601 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 526227008602 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 526227008603 tetramer interface [polypeptide binding]; other site 526227008604 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227008605 catalytic residue [active] 526227008606 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 526227008607 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 526227008608 active site 526227008609 catalytic site [active] 526227008610 metal binding site [ion binding]; metal-binding site 526227008611 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 526227008612 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 526227008613 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 526227008614 Competence protein; Region: Competence; cl00471 526227008615 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 526227008616 ParB-like nuclease domain; Region: ParBc; cl02129 526227008617 ParB-like partition proteins; Region: parB_part; TIGR00180 526227008618 Helix-turn-helix domains; Region: HTH; cl00088 526227008619 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 526227008620 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 526227008621 P-loop; other site 526227008622 Magnesium ion binding site [ion binding]; other site 526227008623 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 526227008624 Magnesium ion binding site [ion binding]; other site 526227008625 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 526227008626 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 526227008627 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227008628 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 526227008629 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 526227008630 active site residue [active] 526227008631 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 526227008632 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 526227008633 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 526227008634 Moco binding site; other site 526227008635 metal coordination site [ion binding]; other site 526227008636 Cytochrome c; Region: Cytochrom_C; cl11414 526227008637 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 526227008638 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227008639 binding surface 526227008640 TPR motif; other site 526227008641 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227008642 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 526227008643 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 526227008644 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 526227008645 active site 526227008646 catalytic residues [active] 526227008647 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 526227008648 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526227008649 dimerization interface [polypeptide binding]; other site 526227008650 putative DNA binding site [nucleotide binding]; other site 526227008651 putative Zn2+ binding site [ion binding]; other site 526227008652 hydrogenase 4 subunit B; Validated; Region: PRK06521 526227008653 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 526227008654 NADH dehydrogenase; Region: NADHdh; cl00469 526227008655 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 526227008656 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 526227008657 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16919 526227008658 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 526227008659 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 526227008660 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 526227008661 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 526227008662 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 526227008663 putative active site [active] 526227008664 Transcriptional regulators [Transcription]; Region: PurR; COG1609 526227008665 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 526227008666 DNA binding site [nucleotide binding] 526227008667 domain linker motif; other site 526227008668 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 526227008669 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 526227008670 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227008671 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 526227008672 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227008673 dimer interface [polypeptide binding]; other site 526227008674 conserved gate region; other site 526227008675 putative PBP binding loops; other site 526227008676 ABC-ATPase subunit interface; other site 526227008677 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 526227008678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227008679 dimer interface [polypeptide binding]; other site 526227008680 conserved gate region; other site 526227008681 putative PBP binding loops; other site 526227008682 ABC-ATPase subunit interface; other site 526227008683 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 526227008684 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 526227008685 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 526227008686 dimer interface [polypeptide binding]; other site 526227008687 putative radical transfer pathway; other site 526227008688 diiron center [ion binding]; other site 526227008689 tyrosyl radical; other site 526227008690 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 526227008691 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 526227008692 Class I ribonucleotide reductase; Region: RNR_I; cd01679 526227008693 active site 526227008694 dimer interface [polypeptide binding]; other site 526227008695 catalytic residues [active] 526227008696 effector binding site; other site 526227008697 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 526227008698 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 526227008699 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227008700 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227008701 GAF domain; Region: GAF; cl15785 526227008702 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526227008703 metal binding site [ion binding]; metal-binding site 526227008704 active site 526227008705 I-site; other site 526227008706 Helix-turn-helix domains; Region: HTH; cl00088 526227008707 putative transposase OrfB; Reviewed; Region: PHA02517 526227008708 Integrase core domain; Region: rve; cl01316 526227008709 Integrase core domain; Region: rve_3; cl15866 526227008710 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 526227008711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 526227008712 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 526227008713 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 526227008714 Walker A/P-loop; other site 526227008715 ATP binding site [chemical binding]; other site 526227008716 Q-loop/lid; other site 526227008717 ABC transporter signature motif; other site 526227008718 Walker B; other site 526227008719 D-loop; other site 526227008720 H-loop/switch region; other site 526227008721 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 526227008722 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 526227008723 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 526227008724 Walker A/P-loop; other site 526227008725 ATP binding site [chemical binding]; other site 526227008726 Q-loop/lid; other site 526227008727 ABC transporter signature motif; other site 526227008728 Walker B; other site 526227008729 D-loop; other site 526227008730 H-loop/switch region; other site 526227008731 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227008732 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 526227008733 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 526227008734 RES domain; Region: RES; cl02411 526227008735 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 526227008736 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 526227008737 hypothetical protein; Provisional; Region: PRK08185 526227008738 intersubunit interface [polypeptide binding]; other site 526227008739 active site 526227008740 zinc binding site [ion binding]; other site 526227008741 Na+ binding site [ion binding]; other site 526227008742 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 526227008743 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 526227008744 substrate binding site [chemical binding]; other site 526227008745 hexamer interface [polypeptide binding]; other site 526227008746 metal binding site [ion binding]; metal-binding site 526227008747 phosphoribulokinase; Provisional; Region: PRK07429 526227008748 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227008749 active site 526227008750 probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880 526227008751 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227008752 Walker A motif; other site 526227008753 ATP binding site [chemical binding]; other site 526227008754 Walker B motif; other site 526227008755 arginine finger; other site 526227008756 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 526227008757 multimerization interface [polypeptide binding]; other site 526227008758 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 526227008759 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 526227008760 homodimer interface [polypeptide binding]; other site 526227008761 active site 526227008762 heterodimer interface [polypeptide binding]; other site 526227008763 catalytic residue [active] 526227008764 metal binding site [ion binding]; metal-binding site 526227008765 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 526227008766 putative active site [active] 526227008767 Helix-turn-helix domains; Region: HTH; cl00088 526227008768 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 526227008769 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227008770 dimerization interface [polypeptide binding]; other site 526227008771 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 526227008772 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 526227008773 haloacid dehalogenase-like hydrolase family protein; Region: PLN02779 526227008774 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526227008775 motif II; other site 526227008776 transketolase; Reviewed; Region: PRK05899 526227008777 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 526227008778 TPP-binding site [chemical binding]; other site 526227008779 dimer interface [polypeptide binding]; other site 526227008780 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 526227008781 PYR/PP interface [polypeptide binding]; other site 526227008782 dimer interface [polypeptide binding]; other site 526227008783 TPP binding site [chemical binding]; other site 526227008784 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 526227008785 Protein of unknown function (DUF3422); Region: DUF3422; cl02073 526227008786 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227008787 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227008788 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 526227008789 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 526227008790 putative active site [active] 526227008791 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 526227008792 DNA-binding site [nucleotide binding]; DNA binding site 526227008793 FCD domain; Region: FCD; cl11656 526227008794 Helix-turn-helix domains; Region: HTH; cl00088 526227008795 putative transposase OrfB; Reviewed; Region: PHA02517 526227008796 Integrase core domain; Region: rve; cl01316 526227008797 Integrase core domain; Region: rve_3; cl15866 526227008798 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 526227008799 CoA-transferase family III; Region: CoA_transf_3; pfam02515 526227008800 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 526227008801 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 526227008802 Walker A/P-loop; other site 526227008803 ATP binding site [chemical binding]; other site 526227008804 Q-loop/lid; other site 526227008805 ABC transporter signature motif; other site 526227008806 Walker B; other site 526227008807 D-loop; other site 526227008808 H-loop/switch region; other site 526227008809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 526227008810 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 526227008811 NMT1-like family; Region: NMT1_2; cl15260 526227008812 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 526227008813 active site 526227008814 catalytic residues [active] 526227008815 metal binding site [ion binding]; metal-binding site 526227008816 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 526227008817 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 526227008818 Transposase domain (DUF772); Region: DUF772; pfam05598 526227008819 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 526227008820 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 526227008821 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 526227008822 N-formylglutamate amidohydrolase; Region: FGase; cl01522 526227008823 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 526227008824 Helix-turn-helix domains; Region: HTH; cl00088 526227008825 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227008826 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227008827 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 526227008828 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 526227008829 Walker A/P-loop; other site 526227008830 ATP binding site [chemical binding]; other site 526227008831 Q-loop/lid; other site 526227008832 ABC transporter signature motif; other site 526227008833 Walker B; other site 526227008834 D-loop; other site 526227008835 H-loop/switch region; other site 526227008836 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 526227008837 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 526227008838 Walker A/P-loop; other site 526227008839 ATP binding site [chemical binding]; other site 526227008840 Q-loop/lid; other site 526227008841 ABC transporter signature motif; other site 526227008842 Walker B; other site 526227008843 D-loop; other site 526227008844 H-loop/switch region; other site 526227008845 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 526227008846 TM-ABC transporter signature motif; other site 526227008847 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 526227008848 TM-ABC transporter signature motif; other site 526227008849 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 526227008850 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 526227008851 putative ligand binding site [chemical binding]; other site 526227008852 Putative cyclase; Region: Cyclase; cl00814 526227008853 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 526227008854 Spore germination protein; Region: Spore_permease; cl15802 526227008855 Spore germination protein; Region: Spore_permease; cl15802 526227008856 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 526227008857 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 526227008858 DNA-binding site [nucleotide binding]; DNA binding site 526227008859 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 526227008860 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227008861 homodimer interface [polypeptide binding]; other site 526227008862 catalytic residue [active] 526227008863 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 526227008864 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 526227008865 short chain dehydrogenase; Provisional; Region: PRK06138 526227008866 classical (c) SDRs; Region: SDR_c; cd05233 526227008867 NAD(P) binding site [chemical binding]; other site 526227008868 active site 526227008869 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 526227008870 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 526227008871 NAD(P) binding site [chemical binding]; other site 526227008872 catalytic residues [active] 526227008873 GAF domain; Region: GAF; cl15785 526227008874 GAF domain; Region: GAF; cl15785 526227008875 GAF domain; Region: GAF_2; pfam13185 526227008876 GAF domain; Region: GAF; cl15785 526227008877 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526227008878 metal binding site [ion binding]; metal-binding site 526227008879 active site 526227008880 I-site; other site 526227008881 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 526227008882 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 526227008883 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 526227008884 Walker A/P-loop; other site 526227008885 ATP binding site [chemical binding]; other site 526227008886 Q-loop/lid; other site 526227008887 ABC transporter signature motif; other site 526227008888 Walker B; other site 526227008889 D-loop; other site 526227008890 H-loop/switch region; other site 526227008891 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 526227008892 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 526227008893 active site 526227008894 dimer interface [polypeptide binding]; other site 526227008895 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 526227008896 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 526227008897 homodimer interface [polypeptide binding]; other site 526227008898 substrate-cofactor binding pocket; other site 526227008899 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227008900 catalytic residue [active] 526227008901 sulfite reductase subunit beta; Provisional; Region: PRK13504 526227008902 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 526227008903 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 526227008904 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 526227008905 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 526227008906 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 526227008907 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227008908 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 526227008909 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227008910 Walker A/P-loop; other site 526227008911 ATP binding site [chemical binding]; other site 526227008912 Q-loop/lid; other site 526227008913 ABC transporter signature motif; other site 526227008914 Walker B; other site 526227008915 D-loop; other site 526227008916 H-loop/switch region; other site 526227008917 TOBE-like domain; Region: TOBE_3; pfam12857 526227008918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227008919 dimer interface [polypeptide binding]; other site 526227008920 conserved gate region; other site 526227008921 putative PBP binding loops; other site 526227008922 ABC-ATPase subunit interface; other site 526227008923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227008924 dimer interface [polypeptide binding]; other site 526227008925 conserved gate region; other site 526227008926 putative PBP binding loops; other site 526227008927 ABC-ATPase subunit interface; other site 526227008928 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227008929 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 526227008930 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 526227008931 ATP-sulfurylase; Region: ATPS; cd00517 526227008932 active site 526227008933 HXXH motif; other site 526227008934 flexible loop; other site 526227008935 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 526227008936 Active Sites [active] 526227008937 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 526227008938 ligand-binding site [chemical binding]; other site 526227008939 Shikimate kinase; Region: SKI; pfam01202 526227008940 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 526227008941 Helix-turn-helix domains; Region: HTH; cl00088 526227008942 Predicted membrane protein [Function unknown]; Region: COG1511 526227008943 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 526227008944 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 526227008945 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 526227008946 ABC-2 type transporter; Region: ABC2_membrane; cl11417 526227008947 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 526227008948 putative di-iron ligands [ion binding]; other site 526227008949 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 526227008950 putative active site [active] 526227008951 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 526227008952 putative transposase OrfB; Reviewed; Region: PHA02517 526227008953 Integrase core domain; Region: rve; cl01316 526227008954 Integrase core domain; Region: rve_3; cl15866 526227008955 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 526227008956 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227008957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227008958 dimer interface [polypeptide binding]; other site 526227008959 conserved gate region; other site 526227008960 putative PBP binding loops; other site 526227008961 ABC-ATPase subunit interface; other site 526227008962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 526227008963 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 526227008964 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227008965 Walker A/P-loop; other site 526227008966 ATP binding site [chemical binding]; other site 526227008967 Q-loop/lid; other site 526227008968 ABC transporter signature motif; other site 526227008969 Walker B; other site 526227008970 D-loop; other site 526227008971 H-loop/switch region; other site 526227008972 TOBE domain; Region: TOBE_2; cl01440 526227008973 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 526227008974 Probable transposase; Region: OrfB_IS605; pfam01385 526227008975 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 526227008976 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526227008977 MULE transposase domain; Region: MULE; pfam10551 526227008978 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 526227008979 active site 526227008980 catalytic residues [active] 526227008981 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 526227008982 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 526227008983 putative NAD(P) binding site [chemical binding]; other site 526227008984 putative active site [active] 526227008985 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 526227008986 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 526227008987 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 526227008988 Ligand Binding Site [chemical binding]; other site 526227008989 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 526227008990 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 526227008991 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 526227008992 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 526227008993 Replication initiator protein A; Region: RPA; cl02339 526227008994 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 526227008995 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227008996 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 526227008997 Family description; Region: UvrD_C_2; cl15862 526227008998 DEAD-like helicases superfamily; Region: DEXDc; smart00487 526227008999 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526227009000 ATP binding site [chemical binding]; other site 526227009001 putative Mg++ binding site [ion binding]; other site 526227009002 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526227009003 ATP-binding site [chemical binding]; other site 526227009004 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 526227009005 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526227009006 ATP binding site [chemical binding]; other site 526227009007 putative Mg++ binding site [ion binding]; other site 526227009008 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 526227009009 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526227009010 nucleotide binding region [chemical binding]; other site 526227009011 ATP-binding site [chemical binding]; other site 526227009012 Putative ATP-dependent Lon protease; Region: Lon_2; cl11979 526227009013 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227009014 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227009015 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 526227009016 Tubulin like; Region: Tubulin_2; pfam13809 526227009017 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 526227009018 metal ion-dependent adhesion site (MIDAS); other site 526227009019 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227009020 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227009021 Helix-turn-helix domains; Region: HTH; cl00088 526227009022 WYL domain; Region: WYL; cl14852 526227009023 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 526227009024 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 526227009025 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 526227009026 active site 526227009027 substrate binding site [chemical binding]; other site 526227009028 catalytic site [active] 526227009029 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 526227009030 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227009031 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227009032 DEAD-like helicases superfamily; Region: DEXDc; smart00487 526227009033 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526227009034 ATP binding site [chemical binding]; other site 526227009035 putative Mg++ binding site [ion binding]; other site 526227009036 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526227009037 nucleotide binding region [chemical binding]; other site 526227009038 ATP-binding site [chemical binding]; other site 526227009039 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 526227009040 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 526227009041 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 526227009042 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 526227009043 RNB domain; Region: RNB; pfam00773 526227009044 TROVE domain; Region: TROVE; pfam05731 526227009045 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 526227009046 metal ion-dependent adhesion site (MIDAS); other site 526227009047 putative transposase OrfB; Reviewed; Region: PHA02517 526227009048 Integrase core domain; Region: rve; cl01316 526227009049 Integrase core domain; Region: rve_3; cl15866 526227009050 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 526227009051 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 526227009052 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 526227009053 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09742 526227009054 Helix-turn-helix domains; Region: HTH; cl00088 526227009055 putative transposase OrfB; Reviewed; Region: PHA02517 526227009056 Integrase core domain; Region: rve; cl01316 526227009057 Integrase core domain; Region: rve_3; cl15866 526227009058 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732 526227009059 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl14784 526227009060 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 526227009061 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749 526227009062 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 526227009063 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 526227009064 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cd09748 526227009065 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 526227009066 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 526227009067 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 526227009068 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 526227009069 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 526227009070 CRISPR-associated protein Cas8c/Csd1, subtype I-C/DVULG; Region: cas_Csd1; TIGR01863 526227009071 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 526227009072 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 526227009073 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 526227009074 Predicted transcriptional regulator [Transcription]; Region: COG2378 526227009075 WYL domain; Region: WYL; cl14852 526227009076 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 526227009077 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227009078 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 526227009079 Helix-turn-helix domains; Region: HTH; cl00088 526227009080 DNA binding site [nucleotide binding] 526227009081 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 526227009082 P-loop; other site 526227009083 AAA domain; Region: AAA_31; pfam13614 526227009084 Magnesium ion binding site [ion binding]; other site 526227009085 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 526227009086 Magnesium ion binding site [ion binding]; other site 526227009087 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 526227009088 ParB-like nuclease domain; Region: ParBc; cl02129 526227009089 Transcriptional regulators [Transcription]; Region: PurR; COG1609 526227009090 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 526227009091 DNA binding site [nucleotide binding] 526227009092 domain linker motif; other site 526227009093 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 526227009094 ligand binding site [chemical binding]; other site 526227009095 dimerization interface [polypeptide binding]; other site 526227009096 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 526227009097 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227009098 dimer interface [polypeptide binding]; other site 526227009099 conserved gate region; other site 526227009100 putative PBP binding loops; other site 526227009101 ABC-ATPase subunit interface; other site 526227009102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227009103 dimer interface [polypeptide binding]; other site 526227009104 conserved gate region; other site 526227009105 putative PBP binding loops; other site 526227009106 ABC-ATPase subunit interface; other site 526227009107 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227009108 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 526227009109 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227009110 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 526227009111 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 526227009112 substrate binding pocket [chemical binding]; other site 526227009113 membrane-bound complex binding site; other site 526227009114 hinge residues; other site 526227009115 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 526227009116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 526227009117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227009118 putative PBP binding loops; other site 526227009119 dimer interface [polypeptide binding]; other site 526227009120 ABC-ATPase subunit interface; other site 526227009121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227009122 dimer interface [polypeptide binding]; other site 526227009123 conserved gate region; other site 526227009124 ABC-ATPase subunit interface; other site 526227009125 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 526227009126 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 526227009127 Walker A/P-loop; other site 526227009128 ATP binding site [chemical binding]; other site 526227009129 Q-loop/lid; other site 526227009130 ABC transporter signature motif; other site 526227009131 Walker B; other site 526227009132 D-loop; other site 526227009133 H-loop/switch region; other site 526227009134 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227009135 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227009136 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 526227009137 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 526227009138 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227009139 homodimer interface [polypeptide binding]; other site 526227009140 catalytic residue [active] 526227009141 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 526227009142 catalytic core [active] 526227009143 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 526227009144 homotrimer interface [polypeptide binding]; other site 526227009145 Walker A motif; other site 526227009146 GTP binding site [chemical binding]; other site 526227009147 Walker B motif; other site 526227009148 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 526227009149 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 526227009150 putative dimer interface [polypeptide binding]; other site 526227009151 active site pocket [active] 526227009152 putative cataytic base [active] 526227009153 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 526227009154 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526227009155 metal binding site [ion binding]; metal-binding site 526227009156 active site 526227009157 I-site; other site 526227009158 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 526227009159 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227009160 Lagovirus protein of unknown function (DUF840); Region: DUF840; pfam05801 526227009161 GAF domain; Region: GAF; cl15785 526227009162 GAF domain; Region: GAF; cl15785 526227009163 GAF domain; Region: GAF; cl15785 526227009164 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 526227009165 Zn2+ binding site [ion binding]; other site 526227009166 Mg2+ binding site [ion binding]; other site 526227009167 Helix-turn-helix domains; Region: HTH; cl00088 526227009168 putative transposase OrfB; Reviewed; Region: PHA02517 526227009169 Integrase core domain; Region: rve; cl01316 526227009170 Integrase core domain; Region: rve_3; cl15866 526227009171 GAF domain; Region: GAF; cl15785 526227009172 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526227009173 metal binding site [ion binding]; metal-binding site 526227009174 active site 526227009175 I-site; other site 526227009176 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227009177 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227009178 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 526227009179 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 526227009180 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 526227009181 Class I ribonucleotide reductase; Region: RNR_I; cd01679 526227009182 active site 526227009183 dimer interface [polypeptide binding]; other site 526227009184 catalytic residues [active] 526227009185 effector binding site; other site 526227009186 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 526227009187 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 526227009188 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 526227009189 dimer interface [polypeptide binding]; other site 526227009190 putative radical transfer pathway; other site 526227009191 diiron center [ion binding]; other site 526227009192 tyrosyl radical; other site 526227009193 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 526227009194 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 526227009195 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 526227009196 active site 526227009197 homodimer interface [polypeptide binding]; other site 526227009198 catalytic site [active] 526227009199 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 526227009200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227009201 dimer interface [polypeptide binding]; other site 526227009202 conserved gate region; other site 526227009203 putative PBP binding loops; other site 526227009204 ABC-ATPase subunit interface; other site 526227009205 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 526227009206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227009207 dimer interface [polypeptide binding]; other site 526227009208 conserved gate region; other site 526227009209 putative PBP binding loops; other site 526227009210 ABC-ATPase subunit interface; other site 526227009211 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 526227009212 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227009213 Transcriptional regulators [Transcription]; Region: PurR; COG1609 526227009214 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 526227009215 DNA binding site [nucleotide binding] 526227009216 domain linker motif; other site 526227009217 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 526227009218 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 526227009219 putative active site [active] 526227009220 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 526227009221 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 526227009222 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16919 526227009223 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 526227009224 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 526227009225 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 526227009226 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 526227009227 NADH dehydrogenase; Region: NADHdh; cl00469 526227009228 hydrogenase 4 subunit B; Validated; Region: PRK06521 526227009229 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 526227009230 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526227009231 dimerization interface [polypeptide binding]; other site 526227009232 putative DNA binding site [nucleotide binding]; other site 526227009233 putative Zn2+ binding site [ion binding]; other site 526227009234 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 526227009235 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 526227009236 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 526227009237 active site 526227009238 catalytic residues [active] 526227009239 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 526227009240 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227009241 binding surface 526227009242 TPR motif; other site 526227009243 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227009244 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 526227009245 Cytochrome c; Region: Cytochrom_C; cl11414 526227009246 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 526227009247 Moco binding site; other site 526227009248 metal coordination site [ion binding]; other site 526227009249 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 526227009250 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 526227009251 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 526227009252 active site residue [active] 526227009253 Cytochrome c; Region: Cytochrom_C; cl11414 526227009254 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 526227009255 active site 526227009256 metal binding site [ion binding]; metal-binding site 526227009257 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 526227009258 Cytochrome c; Region: Cytochrom_C; cl11414 526227009259 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 526227009260 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 526227009261 Predicted secreted protein [Function unknown]; Region: COG5501 526227009262 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 526227009263 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 526227009264 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 526227009265 catalytic residues [active] 526227009266 Dodecin; Region: Dodecin; cl01328 526227009267 Protein of unknown function (DUF981); Region: DUF981; cl01337 526227009268 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 526227009269 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 526227009270 catalytic motif [active] 526227009271 Zn binding site [ion binding]; other site 526227009272 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 526227009273 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 526227009274 Lumazine binding domain; Region: Lum_binding; pfam00677 526227009275 Lumazine binding domain; Region: Lum_binding; pfam00677 526227009276 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 526227009277 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 526227009278 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 526227009279 dimerization interface [polypeptide binding]; other site 526227009280 active site 526227009281 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 526227009282 homopentamer interface [polypeptide binding]; other site 526227009283 active site 526227009284 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526227009285 dimerization interface [polypeptide binding]; other site 526227009286 putative DNA binding site [nucleotide binding]; other site 526227009287 putative Zn2+ binding site [ion binding]; other site 526227009288 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 526227009289 active site residue [active] 526227009290 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 526227009291 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 526227009292 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526227009293 Zn binding site [ion binding]; other site 526227009294 Cytochrome c; Region: Cytochrom_C; cl11414 526227009295 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 526227009296 hydrophobic ligand binding site; other site 526227009297 GYD domain; Region: GYD; cl01743 526227009298 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 526227009299 Predicted ATPase [General function prediction only]; Region: COG3903 526227009300 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227009301 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227009302 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227009303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227009304 Walker A motif; other site 526227009305 ATP binding site [chemical binding]; other site 526227009306 Walker B motif; other site 526227009307 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 526227009308 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 526227009309 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227009310 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227009311 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526227009312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227009313 active site 526227009314 phosphorylation site [posttranslational modification] 526227009315 intermolecular recognition site; other site 526227009316 dimerization interface [polypeptide binding]; other site 526227009317 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526227009318 DNA binding residues [nucleotide binding] 526227009319 dimerization interface [polypeptide binding]; other site 526227009320 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 526227009321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227009322 ATP binding site [chemical binding]; other site 526227009323 Mg2+ binding site [ion binding]; other site 526227009324 G-X-G motif; other site 526227009325 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 526227009326 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 526227009327 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 526227009328 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 526227009329 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227009330 K+-transporting ATPase, c chain; Region: KdpC; cl00944 526227009331 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 526227009332 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 526227009333 Ligand Binding Site [chemical binding]; other site 526227009334 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 526227009335 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 526227009336 Walker A/P-loop; other site 526227009337 ATP binding site [chemical binding]; other site 526227009338 Q-loop/lid; other site 526227009339 ABC transporter signature motif; other site 526227009340 Walker B; other site 526227009341 D-loop; other site 526227009342 H-loop/switch region; other site 526227009343 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; cl15413 526227009344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227009345 dimer interface [polypeptide binding]; other site 526227009346 conserved gate region; other site 526227009347 putative PBP binding loops; other site 526227009348 ABC-ATPase subunit interface; other site 526227009349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 526227009350 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 526227009351 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 526227009352 DdrB-like protein; Region: DdrB; pfam12747 526227009353 putative transposase OrfB; Reviewed; Region: PHA02517 526227009354 Integrase core domain; Region: rve; cl01316 526227009355 Integrase core domain; Region: rve_3; cl15866 526227009356 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 526227009357 putative active site [active] 526227009358 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 526227009359 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 526227009360 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 526227009361 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 526227009362 Helix-turn-helix domains; Region: HTH; cl00088 526227009363 Predicted transcriptional regulator [Transcription]; Region: COG2378 526227009364 WYL domain; Region: WYL; cl14852 526227009365 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227009366 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 526227009367 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 526227009368 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 526227009369 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 526227009370 putative transposase OrfB; Reviewed; Region: PHA02517 526227009371 Integrase core domain; Region: rve; cl01316 526227009372 Helix-turn-helix domains; Region: HTH; cl00088 526227009373 putative transposase OrfB; Reviewed; Region: PHA02517 526227009374 Integrase core domain; Region: rve; cl01316 526227009375 Integrase core domain; Region: rve_3; cl15866 526227009376 putative transposase OrfB; Reviewed; Region: PHA02517 526227009377 Integrase core domain; Region: rve; cl01316 526227009378 Integrase core domain; Region: rve_3; cl15866 526227009379 Protein of unknown function (DUF433); Region: DUF433; cl01030 526227009380 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 526227009381 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 526227009382 substrate-cofactor binding pocket; other site 526227009383 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227009384 catalytic residue [active] 526227009385 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 526227009386 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 526227009387 chorismate binding enzyme; Region: Chorismate_bind; cl10555 526227009388 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 526227009389 Glutamine amidotransferase class-I; Region: GATase; pfam00117 526227009390 glutamine binding [chemical binding]; other site 526227009391 catalytic triad [active] 526227009392 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK01287 526227009393 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 526227009394 active site 526227009395 Int/Topo IB signature motif; other site 526227009396 catalytic residues [active] 526227009397 DNA binding site [nucleotide binding] 526227009398 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526227009399 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526227009400 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 526227009401 CRISPR/Cas system-associated protein Csx16; Region: Csx16_III-U; cl09866 526227009402 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 526227009403 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 526227009404 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 526227009405 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 526227009406 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 526227009407 Probable transposase; Region: OrfB_IS605; pfam01385 526227009408 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 526227009409 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 526227009410 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 526227009411 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 526227009412 RNA/DNA hybrid binding site [nucleotide binding]; other site 526227009413 active site 526227009414 ParB-like nuclease domain; Region: ParBc; cl02129 526227009415 PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734 526227009416 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 526227009417 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 526227009418 non-specific DNA binding site [nucleotide binding]; other site 526227009419 salt bridge; other site 526227009420 sequence-specific DNA binding site [nucleotide binding]; other site 526227009421 Helix-turn-helix domains; Region: HTH; cl00088 526227009422 ParB-like nuclease domain; Region: ParBc; cl02129 526227009423 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 526227009424 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 526227009425 metal ion-dependent adhesion site (MIDAS); other site 526227009426 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 526227009427 ssDNA binding site [nucleotide binding]; other site 526227009428 dimer interface [polypeptide binding]; other site 526227009429 tetramer (dimer of dimers) interface [polypeptide binding]; other site 526227009430 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 526227009431 dimer interface [polypeptide binding]; other site 526227009432 ssDNA binding site [nucleotide binding]; other site 526227009433 tetramer (dimer of dimers) interface [polypeptide binding]; other site 526227009434 DDE superfamily endonuclease; Region: DDE_4; cl15789 526227009435 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227009436 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 526227009437 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 526227009438 N-acetyl-D-glucosamine binding site [chemical binding]; other site 526227009439 catalytic residue [active] 526227009440 GAF domain; Region: GAF_2; pfam13185 526227009441 GAF domain; Region: GAF; cl15785 526227009442 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526227009443 metal binding site [ion binding]; metal-binding site 526227009444 active site 526227009445 I-site; other site 526227009446 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 526227009447 DDE superfamily endonuclease; Region: DDE_4; cl15789 526227009448 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227009449 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 526227009450 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227009451 Family description; Region: UvrD_C_2; cl15862 526227009452 Probable transposase; Region: OrfB_IS605; pfam01385 526227009453 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 526227009454 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 526227009455 Transposase IS200 like; Region: Y1_Tnp; cl00848 526227009456 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227009457 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 526227009458 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 526227009459 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 526227009460 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 526227009461 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 526227009462 Walker A motif; other site 526227009463 ATP binding site [chemical binding]; other site 526227009464 Walker B motif; other site 526227009465 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 526227009466 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227009467 Walker A motif; other site 526227009468 ATP binding site [chemical binding]; other site 526227009469 Walker B motif; other site 526227009470 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 526227009471 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 526227009472 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 526227009473 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 526227009474 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 526227009475 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 526227009476 Endodeoxyribonuclease RusA; Region: RusA; cl01885 526227009477 replicative DNA helicase; Region: DnaB; TIGR00665 526227009478 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 526227009479 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 526227009480 Walker A motif; other site 526227009481 ATP binding site [chemical binding]; other site 526227009482 Walker B motif; other site 526227009483 DNA binding loops [nucleotide binding] 526227009484 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 526227009485 general secretion pathway protein H; Region: typeII_sec_gspH; TIGR01708 526227009486 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 526227009487 NlpC/P60 family; Region: NLPC_P60; cl11438 526227009488 Exonuclease VII, large subunit; Region: Exonuc_VII_L; pfam02601 526227009489 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 526227009490 CRISPR/Cas system-associated protein Csx16; Region: Csx16_III-U; cl09866 526227009491 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227009492 Walker A motif; other site 526227009493 ATP binding site [chemical binding]; other site 526227009494 Walker B motif; other site 526227009495 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 526227009496 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227009497 Walker A motif; other site 526227009498 ATP binding site [chemical binding]; other site 526227009499 Walker B motif; other site 526227009500 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 526227009501 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 526227009502 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227009503 Walker A motif; other site 526227009504 ATP binding site [chemical binding]; other site 526227009505 Walker B motif; other site 526227009506 Probable transposase; Region: OrfB_IS605; pfam01385 526227009507 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 526227009508 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 526227009509 diaminopimelate epimerase; Region: DapF; TIGR00652 526227009510 AAA-like domain; Region: AAA_10; pfam12846 526227009511 Domain of unknown function DUF87; Region: DUF87; pfam01935 526227009512 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 526227009513 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 526227009514 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 526227009515 active site 526227009516 Int/Topo IB signature motif; other site 526227009517 catalytic residues [active] 526227009518 DNA binding site [nucleotide binding] 526227009519 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526227009520 ATP binding site [chemical binding]; other site 526227009521 putative Mg++ binding site [ion binding]; other site 526227009522 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526227009523 nucleotide binding region [chemical binding]; other site 526227009524 ATP-binding site [chemical binding]; other site 526227009525 N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178 526227009526 putative homodimer interface [polypeptide binding]; other site 526227009527 putative active site [active] 526227009528 catalytic site [active] 526227009529 DEAD-like helicases superfamily; Region: DEXDc; smart00487 526227009530 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526227009531 ATP binding site [chemical binding]; other site 526227009532 putative Mg++ binding site [ion binding]; other site 526227009533 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526227009534 nucleotide binding region [chemical binding]; other site 526227009535 ATP-binding site [chemical binding]; other site 526227009536 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 526227009537 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 526227009538 S-layer homology domain; Region: SLH; pfam00395 526227009539 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 526227009540 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 526227009541 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 526227009542 Family description; Region: UvrD_C_2; cl15862 526227009543 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 526227009544 YcfA-like protein; Region: YcfA; cl00752 526227009545 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 526227009546 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 526227009547 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 526227009548 P-loop; other site 526227009549 Magnesium ion binding site [ion binding]; other site 526227009550 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 526227009551 Magnesium ion binding site [ion binding]; other site 526227009552 ParB-like nuclease domain; Region: ParBc; cl02129 526227009553 KorB domain; Region: KorB; pfam08535