-- dump date 20120504_152001 -- class Genbank::misc_feature -- table misc_feature_note -- id note 266835000001 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 266835000002 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 266835000003 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 266835000004 catalytic triad [active] 266835000005 Protein of unknown function; Region: DUF3971; pfam13116 266835000006 AsmA-like C-terminal region; Region: AsmA_2; cl15864 266835000007 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 266835000008 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 266835000009 active site 266835000010 HIGH motif; other site 266835000011 dimer interface [polypeptide binding]; other site 266835000012 KMSKS motif; other site 266835000013 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266835000014 RNA binding surface [nucleotide binding]; other site 266835000015 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 266835000016 Ligand binding site; other site 266835000017 Putative Catalytic site; other site 266835000018 DXD motif; other site 266835000019 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 266835000020 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 266835000021 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 266835000022 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 266835000023 active site 266835000024 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 266835000025 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 266835000026 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835000027 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266835000028 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 266835000029 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835000030 catalytic residue [active] 266835000031 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 266835000032 putative ABC transporter; Region: ycf24; CHL00085 266835000033 FeS assembly ATPase SufC; Region: sufC; TIGR01978 266835000034 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 266835000035 Walker A/P-loop; other site 266835000036 ATP binding site [chemical binding]; other site 266835000037 Q-loop/lid; other site 266835000038 ABC transporter signature motif; other site 266835000039 Walker B; other site 266835000040 D-loop; other site 266835000041 H-loop/switch region; other site 266835000042 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 266835000043 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 266835000044 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 266835000045 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 266835000046 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835000047 catalytic residue [active] 266835000048 Domain of unknown function DUF59; Region: DUF59; cl00941 266835000049 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 266835000050 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 266835000051 TfoX N-terminal domain; Region: TfoX_N; cl01167 266835000052 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 266835000053 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 266835000054 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266835000055 substrate binding site [chemical binding]; other site 266835000056 ATP binding site [chemical binding]; other site 266835000057 recombinase A; Provisional; Region: recA; PRK09354 266835000058 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 266835000059 hexamer interface [polypeptide binding]; other site 266835000060 Walker A motif; other site 266835000061 ATP binding site [chemical binding]; other site 266835000062 Walker B motif; other site 266835000063 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 266835000064 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 266835000065 motif 1; other site 266835000066 active site 266835000067 motif 2; other site 266835000068 motif 3; other site 266835000069 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 266835000070 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835000071 GST_N family, Class Phi subfamily; composed of plant-specific class Phi GSTs and related fungal and bacterial proteins. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide...; Region: GST_N_Phi; cd03053 266835000072 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835000073 C-terminal domain interface [polypeptide binding]; other site 266835000074 GSH binding site (G-site) [chemical binding]; other site 266835000075 dimer interface [polypeptide binding]; other site 266835000076 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 266835000077 dimer interface [polypeptide binding]; other site 266835000078 substrate binding pocket (H-site) [chemical binding]; other site 266835000079 N-terminal domain interface [polypeptide binding]; other site 266835000080 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 266835000081 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 266835000082 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 266835000083 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 266835000084 Exoribonuclease R [Transcription]; Region: VacB; COG0557 266835000085 RNB domain; Region: RNB; pfam00773 266835000086 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 266835000087 RNA binding site [nucleotide binding]; other site 266835000088 Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450 266835000089 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 266835000090 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 266835000091 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266835000092 RNA binding surface [nucleotide binding]; other site 266835000093 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 266835000094 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 266835000095 Ligand Binding Site [chemical binding]; other site 266835000096 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 266835000097 active site 266835000098 putative lithium-binding site [ion binding]; other site 266835000099 substrate binding site [chemical binding]; other site 266835000100 Gram-negative bacterial tonB protein; Region: TonB; cl10048 266835000101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835000102 putative substrate translocation pore; other site 266835000103 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 266835000104 putative GSH binding site [chemical binding]; other site 266835000105 catalytic residues [active] 266835000106 BolA-like protein; Region: BolA; cl00386 266835000107 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 266835000108 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 266835000109 dimerization interface [polypeptide binding]; other site 266835000110 ATP binding site [chemical binding]; other site 266835000111 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 266835000112 dimerization interface [polypeptide binding]; other site 266835000113 ATP binding site [chemical binding]; other site 266835000114 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266835000115 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835000116 DNA-binding site [nucleotide binding]; DNA binding site 266835000117 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835000118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835000119 homodimer interface [polypeptide binding]; other site 266835000120 catalytic residue [active] 266835000121 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 266835000122 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835000123 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 266835000124 C-terminal domain interface [polypeptide binding]; other site 266835000125 GSH binding site (G-site) [chemical binding]; other site 266835000126 dimer interface [polypeptide binding]; other site 266835000127 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 266835000128 N-terminal domain interface [polypeptide binding]; other site 266835000129 dimer interface [polypeptide binding]; other site 266835000130 substrate binding pocket (H-site) [chemical binding]; other site 266835000131 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 266835000132 putative active site [active] 266835000133 catalytic triad [active] 266835000134 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 266835000135 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 266835000136 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 266835000137 ATP binding site [chemical binding]; other site 266835000138 active site 266835000139 substrate binding site [chemical binding]; other site 266835000140 Domain of unknown function (DUF1476); Region: DUF1476; cl11571 266835000141 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 266835000142 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 266835000143 OpgC protein; Region: OpgC_C; cl00792 266835000144 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835000145 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 266835000146 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 266835000147 putative metal binding site [ion binding]; other site 266835000148 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 266835000149 active site 266835000150 adenylosuccinate lyase; Provisional; Region: PRK07492 266835000151 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 266835000152 tetramer interface [polypeptide binding]; other site 266835000153 active site 266835000154 Predicted secreted protein (DUF2259); Region: DUF2259; cl02309 266835000155 Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; cl01558 266835000156 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 266835000157 putative active site pocket [active] 266835000158 cleavage site 266835000159 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266835000160 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 266835000161 Flavin Reductases; Region: FlaRed; cl00801 266835000162 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835000163 Walker A motif; other site 266835000164 ATP binding site [chemical binding]; other site 266835000165 Walker B motif; other site 266835000166 arginine finger; other site 266835000167 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 266835000168 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 266835000169 metal ion-dependent adhesion site (MIDAS); other site 266835000170 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 266835000171 XdhC Rossmann domain; Region: XdhC_C; pfam13478 266835000172 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 266835000173 putative MPT binding site; other site 266835000174 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 266835000175 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 266835000176 Ligand binding site; other site 266835000177 metal-binding site 266835000178 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 266835000179 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 266835000180 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 266835000181 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 266835000182 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835000183 active site 266835000184 catalytic tetrad [active] 266835000185 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 266835000186 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266835000187 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835000188 catalytic residue [active] 266835000189 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 266835000190 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 266835000191 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 266835000192 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835000193 Coenzyme A binding pocket [chemical binding]; other site 266835000194 Protein of unknown function (DUF523); Region: DUF523; cl00733 266835000195 Uncharacterized conserved protein [Function unknown]; Region: COG3246 266835000196 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 266835000197 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 266835000198 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835000199 inhibitor-cofactor binding pocket; inhibition site 266835000200 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835000201 catalytic residue [active] 266835000202 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 266835000203 ParB-like nuclease domain; Region: ParBc; cl02129 266835000204 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 266835000205 putative hydrophobic ligand binding site [chemical binding]; other site 266835000206 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 266835000207 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 266835000208 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 266835000209 Bacitracin resistance protein BacA; Region: BacA; cl00858 266835000210 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 266835000211 Predicted periplasmic protein [Function unknown]; Region: COG3698 266835000212 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 266835000213 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 266835000214 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 266835000215 Protein of unknown function (DUF1402); Region: DUF1402; pfam07182 266835000216 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14954 266835000217 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 266835000218 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 266835000219 active site 266835000220 MoeA C-terminal region (domain IV); Region: MoeA_C; pfam03454 266835000221 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 266835000222 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835000223 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266835000224 Helix-turn-helix domains; Region: HTH; cl00088 266835000225 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266835000226 dimerization interface [polypeptide binding]; other site 266835000227 substrate binding pocket [chemical binding]; other site 266835000228 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835000229 S-adenosylmethionine binding site [chemical binding]; other site 266835000230 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 266835000231 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 266835000232 OpgC protein; Region: OpgC_C; cl00792 266835000233 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 266835000234 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 266835000235 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 266835000236 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 266835000237 active site 266835000238 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 266835000239 TSCPD domain; Region: TSCPD; cl14834 266835000240 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 266835000241 nudix motif; other site 266835000242 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 266835000243 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266835000244 active site 266835000245 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 266835000246 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266835000247 Ligand Binding Site [chemical binding]; other site 266835000248 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 266835000249 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 266835000250 putative MPT binding site; other site 266835000251 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 266835000252 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835000253 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 266835000254 Protein of unknown function (DUF982); Region: DUF982; pfam06169 266835000255 Bacterial SH3 domain; Region: SH3_3; cl02551 266835000256 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 266835000257 active site 266835000258 FMN binding site [chemical binding]; other site 266835000259 substrate binding site [chemical binding]; other site 266835000260 homotetramer interface [polypeptide binding]; other site 266835000261 catalytic residue [active] 266835000262 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 266835000263 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 266835000264 dimer interface [polypeptide binding]; other site 266835000265 ADP-ribose binding site [chemical binding]; other site 266835000266 active site 266835000267 nudix motif; other site 266835000268 metal binding site [ion binding]; metal-binding site 266835000269 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 266835000270 active sites [active] 266835000271 tetramer interface [polypeptide binding]; other site 266835000272 Surface antigen; Region: Surface_Ag_2; cl01155 266835000273 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 266835000274 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 266835000275 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266835000276 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 266835000277 active site 266835000278 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266835000279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 266835000280 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 266835000281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 266835000282 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 266835000283 threonine dehydratase; Validated; Region: PRK08639 266835000284 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 266835000285 tetramer interface [polypeptide binding]; other site 266835000286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835000287 catalytic residue [active] 266835000288 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 266835000289 putative Ile/Val binding site [chemical binding]; other site 266835000290 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 266835000291 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 266835000292 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835000293 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 266835000294 dimer interface [polypeptide binding]; other site 266835000295 active site 266835000296 metal binding site [ion binding]; metal-binding site 266835000297 glutathione binding site [chemical binding]; other site 266835000298 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 266835000299 DNA-binding site [nucleotide binding]; DNA binding site 266835000300 RNA-binding motif; other site 266835000301 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 266835000302 DNA-binding site [nucleotide binding]; DNA binding site 266835000303 RNA-binding motif; other site 266835000304 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 266835000305 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835000306 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835000307 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 266835000308 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 266835000309 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835000310 serine acetyltransferase; Provisional; Region: cysE; PRK11132 266835000311 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 266835000312 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 266835000313 trimer interface [polypeptide binding]; other site 266835000314 active site 266835000315 substrate binding site [chemical binding]; other site 266835000316 CoA binding site [chemical binding]; other site 266835000317 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 266835000318 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 266835000319 trimer interface [polypeptide binding]; other site 266835000320 putative metal binding site [ion binding]; other site 266835000321 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 266835000322 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 266835000323 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 266835000324 PilZ domain; Region: PilZ; cl01260 266835000325 PilZ domain; Region: PilZ; cl01260 266835000326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 266835000327 PAS domain; Region: PAS_5; pfam07310 266835000328 Rhomboid family; Region: Rhomboid; cl11446 266835000329 FOG: CBS domain [General function prediction only]; Region: COG0517 266835000330 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 266835000331 Uncharacterized protein conserved in bacteria (DUF2084); Region: DUF2084; cl01566 266835000332 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 266835000333 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 266835000334 GatB domain; Region: GatB_Yqey; cl11497 266835000335 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 266835000336 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835000337 Protein of unknown function DUF124; Region: DUF124; cl00884 266835000338 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 266835000339 Pantoate-beta-alanine ligase; Region: PanC; cd00560 266835000340 active site 266835000341 ATP-binding site [chemical binding]; other site 266835000342 pantoate-binding site; other site 266835000343 HXXH motif; other site 266835000344 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 266835000345 oligomerization interface [polypeptide binding]; other site 266835000346 active site 266835000347 metal binding site [ion binding]; metal-binding site 266835000348 NADH ubiquinone oxidoreductase subunit NDUFA12; Region: NDUFA12; cl01534 266835000349 Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; cl01970 266835000350 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835000351 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 266835000352 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266835000353 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 266835000354 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 266835000355 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 266835000356 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266835000357 carboxyltransferase (CT) interaction site; other site 266835000358 biotinylation site [posttranslational modification]; other site 266835000359 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 266835000360 trimer interface [polypeptide binding]; other site 266835000361 active site 266835000362 dimer interface [polypeptide binding]; other site 266835000363 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 266835000364 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 266835000365 catalytic residues [active] 266835000366 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 266835000367 Peptidase family M48; Region: Peptidase_M48; cl12018 266835000368 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835000369 TPR motif; other site 266835000370 binding surface 266835000371 aspartate aminotransferase; Provisional; Region: PRK05764 266835000372 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835000373 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835000374 homodimer interface [polypeptide binding]; other site 266835000375 catalytic residue [active] 266835000376 Glutaminase; Region: Glutaminase; cl00907 266835000377 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 266835000378 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 266835000379 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 266835000380 AMIN domain; Region: AMIN; pfam11741 266835000381 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 266835000382 active site 266835000383 metal binding site [ion binding]; metal-binding site 266835000384 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 266835000385 Transglycosylase; Region: Transgly; cl07896 266835000386 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 266835000387 peptide chain release factor 2; Provisional; Region: PRK07342 266835000388 RF-1 domain; Region: RF-1; cl02875 266835000389 RF-1 domain; Region: RF-1; cl02875 266835000390 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 266835000391 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266835000392 ligand binding site [chemical binding]; other site 266835000393 helicase 45; Provisional; Region: PTZ00424 266835000394 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 266835000395 ATP binding site [chemical binding]; other site 266835000396 Mg++ binding site [ion binding]; other site 266835000397 motif III; other site 266835000398 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266835000399 nucleotide binding region [chemical binding]; other site 266835000400 ATP-binding site [chemical binding]; other site 266835000401 ribonuclease E; Reviewed; Region: rne; PRK10811 266835000402 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 266835000403 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835000404 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835000405 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 266835000406 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 266835000407 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835000408 Helix-turn-helix domains; Region: HTH; cl00088 266835000409 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266835000410 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835000411 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835000412 Walker A/P-loop; other site 266835000413 ATP binding site [chemical binding]; other site 266835000414 Q-loop/lid; other site 266835000415 ABC transporter signature motif; other site 266835000416 Walker B; other site 266835000417 D-loop; other site 266835000418 H-loop/switch region; other site 266835000419 TOBE domain; Region: TOBE_2; cl01440 266835000420 TOBE domain; Region: TOBE_2; cl01440 266835000421 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835000422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835000423 dimer interface [polypeptide binding]; other site 266835000424 conserved gate region; other site 266835000425 putative PBP binding loops; other site 266835000426 ABC-ATPase subunit interface; other site 266835000427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835000428 dimer interface [polypeptide binding]; other site 266835000429 conserved gate region; other site 266835000430 putative PBP binding loops; other site 266835000431 ABC-ATPase subunit interface; other site 266835000432 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835000433 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835000434 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835000435 Helix-turn-helix domains; Region: HTH; cl00088 266835000436 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835000437 Helix-turn-helix domains; Region: HTH; cl00088 266835000438 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835000439 dimerization interface [polypeptide binding]; other site 266835000440 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 266835000441 NmrA-like family; Region: NmrA; pfam05368 266835000442 NADP binding site [chemical binding]; other site 266835000443 active site 266835000444 regulatory binding site [polypeptide binding]; other site 266835000445 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835000446 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266835000447 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 266835000448 NADH(P)-binding; Region: NAD_binding_10; pfam13460 266835000449 NAD binding site [chemical binding]; other site 266835000450 substrate binding site [chemical binding]; other site 266835000451 putative active site [active] 266835000452 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 266835000453 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835000454 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835000455 Helix-turn-helix domains; Region: HTH; cl00088 266835000456 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 266835000457 putative effector binding pocket; other site 266835000458 putative dimerization interface [polypeptide binding]; other site 266835000459 BA14K-like protein; Region: BA14K; pfam07886 266835000460 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266835000461 Helix-turn-helix domains; Region: HTH; cl00088 266835000462 Bacterial transcriptional regulator; Region: IclR; pfam01614 266835000463 glyoxylate carboligase; Provisional; Region: PRK11269 266835000464 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266835000465 PYR/PP interface [polypeptide binding]; other site 266835000466 dimer interface [polypeptide binding]; other site 266835000467 TPP binding site [chemical binding]; other site 266835000468 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 266835000469 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 266835000470 TPP-binding site [chemical binding]; other site 266835000471 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 266835000472 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835000473 tartronate semialdehyde reductase; Provisional; Region: PRK15059 266835000474 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 266835000475 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 266835000476 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 266835000477 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 266835000478 elongation factor Tu; Reviewed; Region: PRK00049 266835000479 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 266835000480 G1 box; other site 266835000481 GEF interaction site [polypeptide binding]; other site 266835000482 GTP/Mg2+ binding site [chemical binding]; other site 266835000483 Switch I region; other site 266835000484 G2 box; other site 266835000485 G3 box; other site 266835000486 Switch II region; other site 266835000487 G4 box; other site 266835000488 G5 box; other site 266835000489 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 266835000490 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 266835000491 Antibiotic Binding Site [chemical binding]; other site 266835000492 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 266835000493 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 266835000494 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 266835000495 apolar tunnel; other site 266835000496 heme binding site [chemical binding]; other site 266835000497 dimerization interface [polypeptide binding]; other site 266835000498 Putative glycolipid-binding; Region: Glycolipid_bind; cl01425 266835000499 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 266835000500 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 266835000501 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 266835000502 putative homodimer interface [polypeptide binding]; other site 266835000503 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 266835000504 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 266835000505 23S rRNA interface [nucleotide binding]; other site 266835000506 L7/L12 interface [polypeptide binding]; other site 266835000507 putative thiostrepton binding site; other site 266835000508 L25 interface [polypeptide binding]; other site 266835000509 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 266835000510 mRNA/rRNA interface [nucleotide binding]; other site 266835000511 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 266835000512 23S rRNA interface [nucleotide binding]; other site 266835000513 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 266835000514 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 266835000515 L11 interface [polypeptide binding]; other site 266835000516 putative EF-Tu interaction site [polypeptide binding]; other site 266835000517 putative EF-G interaction site [polypeptide binding]; other site 266835000518 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 266835000519 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 266835000520 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 266835000521 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 266835000522 RPB12 interaction site [polypeptide binding]; other site 266835000523 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 266835000524 RPB11 interaction site [polypeptide binding]; other site 266835000525 RPB12 interaction site [polypeptide binding]; other site 266835000526 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 266835000527 RPB1 interaction site [polypeptide binding]; other site 266835000528 RPB11 interaction site [polypeptide binding]; other site 266835000529 RPB10 interaction site [polypeptide binding]; other site 266835000530 RPB3 interaction site [polypeptide binding]; other site 266835000531 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 266835000532 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 266835000533 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 266835000534 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 266835000535 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 266835000536 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 266835000537 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 266835000538 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 266835000539 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 266835000540 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 266835000541 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 266835000542 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 266835000543 DNA binding site [nucleotide binding] 266835000544 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 266835000545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835000546 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835000547 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835000548 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 266835000549 S17 interaction site [polypeptide binding]; other site 266835000550 S8 interaction site; other site 266835000551 16S rRNA interaction site [nucleotide binding]; other site 266835000552 streptomycin interaction site [chemical binding]; other site 266835000553 23S rRNA interaction site [nucleotide binding]; other site 266835000554 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 266835000555 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 266835000556 elongation factor G; Reviewed; Region: PRK00007 266835000557 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved so...; Region: EF-G; cd01886 266835000558 G1 box; other site 266835000559 putative GEF interaction site [polypeptide binding]; other site 266835000560 GTP/Mg2+ binding site [chemical binding]; other site 266835000561 Switch I region; other site 266835000562 G2 box; other site 266835000563 G3 box; other site 266835000564 Switch II region; other site 266835000565 G4 box; other site 266835000566 G5 box; other site 266835000567 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 266835000568 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 266835000569 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 266835000570 elongation factor Tu; Reviewed; Region: PRK00049 266835000571 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 266835000572 G1 box; other site 266835000573 GEF interaction site [polypeptide binding]; other site 266835000574 GTP/Mg2+ binding site [chemical binding]; other site 266835000575 Switch I region; other site 266835000576 G2 box; other site 266835000577 G3 box; other site 266835000578 Switch II region; other site 266835000579 G4 box; other site 266835000580 G5 box; other site 266835000581 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 266835000582 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 266835000583 Antibiotic Binding Site [chemical binding]; other site 266835000584 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 266835000585 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 266835000586 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 266835000587 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 266835000588 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 266835000589 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 266835000590 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 266835000591 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 266835000592 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 266835000593 putative translocon binding site; other site 266835000594 protein-rRNA interface [nucleotide binding]; other site 266835000595 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 266835000596 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 266835000597 G-X-X-G motif; other site 266835000598 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 266835000599 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 266835000600 23S rRNA interface [nucleotide binding]; other site 266835000601 5S rRNA interface [nucleotide binding]; other site 266835000602 putative antibiotic binding site [chemical binding]; other site 266835000603 L25 interface [polypeptide binding]; other site 266835000604 L27 interface [polypeptide binding]; other site 266835000605 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 266835000606 putative translocon interaction site; other site 266835000607 23S rRNA interface [nucleotide binding]; other site 266835000608 signal recognition particle (SRP54) interaction site; other site 266835000609 L23 interface [polypeptide binding]; other site 266835000610 trigger factor interaction site; other site 266835000611 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 266835000612 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 266835000613 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 266835000614 KOW motif; Region: KOW; cl00354 266835000615 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 266835000616 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 266835000617 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 266835000618 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 266835000619 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 266835000620 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 266835000621 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 266835000622 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 266835000623 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 266835000624 5S rRNA interface [nucleotide binding]; other site 266835000625 23S rRNA interface [nucleotide binding]; other site 266835000626 L5 interface [polypeptide binding]; other site 266835000627 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 266835000628 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 266835000629 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 266835000630 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 266835000631 23S rRNA binding site [nucleotide binding]; other site 266835000632 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 266835000633 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 266835000634 SecY translocase; Region: SecY; pfam00344 266835000635 adenylate kinase; Reviewed; Region: adk; PRK00279 266835000636 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 266835000637 AMP-binding site [chemical binding]; other site 266835000638 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 266835000639 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 266835000640 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 266835000641 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 266835000642 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 266835000643 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 266835000644 alphaNTD homodimer interface [polypeptide binding]; other site 266835000645 alphaNTD - beta interaction site [polypeptide binding]; other site 266835000646 alphaNTD - beta' interaction site [polypeptide binding]; other site 266835000647 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 266835000648 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 266835000649 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 266835000650 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 266835000651 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266835000652 protein binding site [polypeptide binding]; other site 266835000653 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266835000654 protein binding site [polypeptide binding]; other site 266835000655 recombination factor protein RarA; Reviewed; Region: PRK13342 266835000656 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835000657 Walker A motif; other site 266835000658 ATP binding site [chemical binding]; other site 266835000659 Walker B motif; other site 266835000660 arginine finger; other site 266835000661 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 266835000662 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 266835000663 Cupin domain; Region: Cupin_2; cl09118 266835000664 CrcB-like protein; Region: CRCB; cl09114 266835000665 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 266835000666 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266835000667 RNA binding surface [nucleotide binding]; other site 266835000668 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 266835000669 active site 266835000670 EamA-like transporter family; Region: EamA; cl01037 266835000671 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 266835000672 EamA-like transporter family; Region: EamA; cl01037 266835000673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835000674 putative substrate translocation pore; other site 266835000675 metabolite-proton symporter; Region: 2A0106; TIGR00883 266835000676 glutamine synthetase; Region: PLN02284 266835000677 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 266835000678 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266835000679 glutamine synthetase; Provisional; Region: glnA; PRK09469 266835000680 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 266835000681 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266835000682 Nitrogen regulatory protein P-II; Region: P-II; cl00412 266835000683 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 266835000684 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 266835000685 putative substrate binding site [chemical binding]; other site 266835000686 putative ATP binding site [chemical binding]; other site 266835000687 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 266835000688 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 266835000689 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 266835000690 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 266835000691 helicase 45; Provisional; Region: PTZ00424 266835000692 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 266835000693 ATP binding site [chemical binding]; other site 266835000694 Mg++ binding site [ion binding]; other site 266835000695 motif III; other site 266835000696 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266835000697 nucleotide binding region [chemical binding]; other site 266835000698 ATP-binding site [chemical binding]; other site 266835000699 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835000700 short chain dehydrogenase; Provisional; Region: PRK06101 266835000701 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 266835000702 putative NAD(P) binding site [chemical binding]; other site 266835000703 active site 266835000704 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 266835000705 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 266835000706 dimer interface [polypeptide binding]; other site 266835000707 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835000708 catalytic residue [active] 266835000709 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 266835000710 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 266835000711 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 266835000712 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 266835000713 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 266835000714 active site residue [active] 266835000715 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 266835000716 active site residue [active] 266835000717 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835000718 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 266835000719 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 266835000720 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 266835000721 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 266835000722 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 266835000723 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 266835000724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835000725 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835000726 Helix-turn-helix domains; Region: HTH; cl00088 266835000727 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 266835000728 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 266835000729 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835000730 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 266835000731 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 266835000732 active site 266835000733 metal binding site [ion binding]; metal-binding site 266835000734 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 266835000735 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 266835000736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835000737 S-adenosylmethionine binding site [chemical binding]; other site 266835000738 Stress responsive A/B Barrel Domain; Region: Dabb; cl06768 266835000739 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 266835000740 NeuB family; Region: NeuB; cl00496 266835000741 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 266835000742 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 266835000743 enolase; Provisional; Region: eno; PRK00077 266835000744 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 266835000745 dimer interface [polypeptide binding]; other site 266835000746 metal binding site [ion binding]; metal-binding site 266835000747 substrate binding pocket [chemical binding]; other site 266835000748 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 266835000749 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 266835000750 putative trimer interface [polypeptide binding]; other site 266835000751 putative CoA binding site [chemical binding]; other site 266835000752 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266835000753 Helix-turn-helix domains; Region: HTH; cl00088 266835000754 Septum formation initiator; Region: DivIC; cl11433 266835000755 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 266835000756 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 266835000757 tetramer interface [polypeptide binding]; other site 266835000758 TPP-binding site [chemical binding]; other site 266835000759 heterodimer interface [polypeptide binding]; other site 266835000760 phosphorylation loop region [posttranslational modification] 266835000761 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 266835000762 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266835000763 E3 interaction surface; other site 266835000764 lipoyl attachment site [posttranslational modification]; other site 266835000765 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 266835000766 alpha subunit interface [polypeptide binding]; other site 266835000767 TPP binding site [chemical binding]; other site 266835000768 heterodimer interface [polypeptide binding]; other site 266835000769 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266835000770 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 266835000771 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266835000772 E3 interaction surface; other site 266835000773 lipoyl attachment site [posttranslational modification]; other site 266835000774 e3 binding domain; Region: E3_binding; pfam02817 266835000775 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 266835000776 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 266835000777 active site 266835000778 catalytic triad [active] 266835000779 oxyanion hole [active] 266835000780 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 266835000781 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835000782 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266835000783 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266835000784 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 266835000785 lipoyl synthase; Provisional; Region: PRK05481 266835000786 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835000787 FeS/SAM binding site; other site 266835000788 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 266835000789 putative coenzyme Q binding site [chemical binding]; other site 266835000790 Competence-damaged protein; Region: CinA; cl00666 266835000791 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 266835000792 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 266835000793 substrate binding site; other site 266835000794 dimer interface; other site 266835000795 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 266835000796 homotrimer interaction site [polypeptide binding]; other site 266835000797 zinc binding site [ion binding]; other site 266835000798 CDP-binding sites; other site 266835000799 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 266835000800 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 266835000801 FMN binding site [chemical binding]; other site 266835000802 active site 266835000803 catalytic residues [active] 266835000804 substrate binding site [chemical binding]; other site 266835000805 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 266835000806 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835000807 dimer interface [polypeptide binding]; other site 266835000808 phosphorylation site [posttranslational modification] 266835000809 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835000810 ATP binding site [chemical binding]; other site 266835000811 Mg2+ binding site [ion binding]; other site 266835000812 G-X-G motif; other site 266835000813 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 266835000814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835000815 active site 266835000816 phosphorylation site [posttranslational modification] 266835000817 intermolecular recognition site; other site 266835000818 dimerization interface [polypeptide binding]; other site 266835000819 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835000820 Walker A motif; other site 266835000821 ATP binding site [chemical binding]; other site 266835000822 Walker B motif; other site 266835000823 arginine finger; other site 266835000824 Helix-turn-helix domains; Region: HTH; cl00088 266835000825 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 266835000826 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266835000827 dimerization interface [polypeptide binding]; other site 266835000828 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 266835000829 putative active site [active] 266835000830 heme pocket [chemical binding]; other site 266835000831 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835000832 dimer interface [polypeptide binding]; other site 266835000833 phosphorylation site [posttranslational modification] 266835000834 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835000835 ATP binding site [chemical binding]; other site 266835000836 Mg2+ binding site [ion binding]; other site 266835000837 G-X-G motif; other site 266835000838 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 266835000839 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835000840 active site 266835000841 phosphorylation site [posttranslational modification] 266835000842 intermolecular recognition site; other site 266835000843 dimerization interface [polypeptide binding]; other site 266835000844 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835000845 Walker A motif; other site 266835000846 ATP binding site [chemical binding]; other site 266835000847 Walker B motif; other site 266835000848 arginine finger; other site 266835000849 Helix-turn-helix domains; Region: HTH; cl00088 266835000850 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 266835000851 homodimer interface [polypeptide binding]; other site 266835000852 substrate-cofactor binding pocket; other site 266835000853 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835000854 Aminotransferase class IV; Region: Aminotran_4; pfam01063 266835000855 catalytic residue [active] 266835000856 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 266835000857 Sm1 motif; other site 266835000858 intra - hexamer interaction site; other site 266835000859 inter - hexamer interaction site [polypeptide binding]; other site 266835000860 nucleotide binding pocket [chemical binding]; other site 266835000861 Sm2 motif; other site 266835000862 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 266835000863 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 266835000864 HflX GTPase family; Region: HflX; cd01878 266835000865 G1 box; other site 266835000866 GTP/Mg2+ binding site [chemical binding]; other site 266835000867 Switch I region; other site 266835000868 G2 box; other site 266835000869 G3 box; other site 266835000870 Switch II region; other site 266835000871 G4 box; other site 266835000872 G5 box; other site 266835000873 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 266835000874 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 266835000875 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 266835000876 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 266835000877 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 266835000878 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835000879 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835000880 homodimer interface [polypeptide binding]; other site 266835000881 catalytic residue [active] 266835000882 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266835000883 catalytic core [active] 266835000884 RNA polymerase sigma factor; Provisional; Region: PRK12511 266835000885 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835000886 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835000887 DNA binding residues [nucleotide binding] 266835000888 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 266835000889 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 266835000890 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 266835000891 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 266835000892 active site 266835000893 catalytic residues [active] 266835000894 Arginase family; Region: Arginase; cl00306 266835000895 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 266835000896 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835000897 Coenzyme A binding pocket [chemical binding]; other site 266835000898 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266835000899 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 266835000900 active site 266835000901 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 266835000902 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 266835000903 active site 266835000904 HIGH motif; other site 266835000905 KMSKS motif; other site 266835000906 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 266835000907 tRNA binding surface [nucleotide binding]; other site 266835000908 anticodon binding site; other site 266835000909 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 266835000910 DNA polymerase III subunit delta'; Validated; Region: PRK09112 266835000911 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835000912 thymidylate kinase; Validated; Region: tmk; PRK00698 266835000913 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 266835000914 TMP-binding site; other site 266835000915 ATP-binding site [chemical binding]; other site 266835000916 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 266835000917 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 266835000918 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 266835000919 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 266835000920 Protein of unknown function (DUF768); Region: DUF768; pfam05589 266835000921 Protein of unknown function (DUF768); Region: DUF768; pfam05589 266835000922 Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539 266835000923 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 266835000924 catalytic residue [active] 266835000925 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 266835000926 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 266835000927 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 266835000928 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 266835000929 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 266835000930 Terminase-like family; Region: Terminase_6; pfam03237 266835000931 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835000932 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 266835000933 Int/Topo IB signature motif; other site 266835000934 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 266835000935 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 266835000936 Catalytic site; other site 266835000937 Uncharacterized conserved protein [Function unknown]; Region: COG4983 266835000938 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 266835000939 integrase; Provisional; Region: PRK09692 266835000940 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 266835000941 active site 266835000942 Int/Topo IB signature motif; other site 266835000943 Domain of unknown function (DUF305); Region: DUF305; cl15795 266835000944 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835000945 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266835000946 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835000947 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 266835000948 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835000949 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835000950 Uncharacterized conserved protein (DUF2161); Region: DUF2161; cl02298 266835000951 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 266835000952 Integral membrane protein TerC family; Region: TerC; cl10468 266835000953 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 266835000954 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 266835000955 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835000956 FeS/SAM binding site; other site 266835000957 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 266835000958 putative ligand binding site [chemical binding]; other site 266835000959 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266835000960 TM-ABC transporter signature motif; other site 266835000961 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266835000962 TM-ABC transporter signature motif; other site 266835000963 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 266835000964 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 266835000965 Walker A/P-loop; other site 266835000966 ATP binding site [chemical binding]; other site 266835000967 Q-loop/lid; other site 266835000968 ABC transporter signature motif; other site 266835000969 Walker B; other site 266835000970 D-loop; other site 266835000971 H-loop/switch region; other site 266835000972 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 266835000973 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 266835000974 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 266835000975 NADP binding site [chemical binding]; other site 266835000976 dimer interface [polypeptide binding]; other site 266835000977 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 266835000978 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 266835000979 Protein of unknown function (DUF1326); Region: DUF1326; cl02375 266835000980 Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486 266835000981 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 266835000982 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 266835000983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835000984 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; cl01548 266835000985 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 266835000986 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 266835000987 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 266835000988 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 266835000989 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 266835000990 catalytic residues [active] 266835000991 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 266835000992 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 266835000993 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 266835000994 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 266835000995 MgtE intracellular N domain; Region: MgtE_N; cl15244 266835000996 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 266835000997 Divalent cation transporter; Region: MgtE; cl00786 266835000998 glutathione reductase; Validated; Region: PRK06116 266835000999 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266835001000 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266835001001 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 266835001002 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 266835001003 tetramer (dimer of dimers) interface [polypeptide binding]; other site 266835001004 active site 266835001005 dimer interface [polypeptide binding]; other site 266835001006 phosphoglycolate phosphatase; Provisional; Region: PRK13222 266835001007 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266835001008 motif II; other site 266835001009 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 266835001010 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 266835001011 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 266835001012 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 266835001013 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266835001014 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835001015 NAD(P) binding site [chemical binding]; other site 266835001016 active site 266835001017 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835001018 Helix-turn-helix domains; Region: HTH; cl00088 266835001019 Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447 266835001020 active site 266835001021 catalytic residue [active] 266835001022 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835001023 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835001024 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266835001025 Helix-turn-helix domains; Region: HTH; cl00088 266835001026 Helix-turn-helix domains; Region: HTH; cl00088 266835001027 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 266835001028 Protein of unknown function (DUF971); Region: DUF971; cl01414 266835001029 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 266835001030 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835001031 FeS/SAM binding site; other site 266835001032 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 266835001033 EamA-like transporter family; Region: EamA; cl01037 266835001034 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 266835001035 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 266835001036 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 266835001037 GTP binding site; other site 266835001038 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 266835001039 Walker A motif; other site 266835001040 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835001041 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266835001042 substrate binding pocket [chemical binding]; other site 266835001043 membrane-bound complex binding site; other site 266835001044 hinge residues; other site 266835001045 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266835001046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835001047 dimer interface [polypeptide binding]; other site 266835001048 conserved gate region; other site 266835001049 putative PBP binding loops; other site 266835001050 ABC-ATPase subunit interface; other site 266835001051 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266835001052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835001053 dimer interface [polypeptide binding]; other site 266835001054 conserved gate region; other site 266835001055 putative PBP binding loops; other site 266835001056 ABC-ATPase subunit interface; other site 266835001057 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266835001058 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835001059 NAD(P) binding pocket [chemical binding]; other site 266835001060 A new structural DNA glycosylase; Region: AlkD_like; cd06561 266835001061 active site 266835001062 Protein of unknown function (DUF3299); Region: DUF3299; cl01387 266835001063 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835001064 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835001065 putative DNA binding site [nucleotide binding]; other site 266835001066 putative Zn2+ binding site [ion binding]; other site 266835001067 Helix-turn-helix domains; Region: HTH; cl00088 266835001068 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 266835001069 putative uracil binding site [chemical binding]; other site 266835001070 putative active site [active] 266835001071 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835001072 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 266835001073 putative C-terminal domain interface [polypeptide binding]; other site 266835001074 putative GSH binding site (G-site) [chemical binding]; other site 266835001075 putative dimer interface [polypeptide binding]; other site 266835001076 C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182 266835001077 putative N-terminal domain interface [polypeptide binding]; other site 266835001078 putative dimer interface [polypeptide binding]; other site 266835001079 putative substrate binding pocket (H-site) [chemical binding]; other site 266835001080 Staphylococcal nuclease homologues; Region: SNc; smart00318 266835001081 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 266835001082 Catalytic site; other site 266835001083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835001084 dimer interface [polypeptide binding]; other site 266835001085 phosphorylation site [posttranslational modification] 266835001086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835001087 ATP binding site [chemical binding]; other site 266835001088 Mg2+ binding site [ion binding]; other site 266835001089 G-X-G motif; other site 266835001090 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 266835001091 putative dimer interface [polypeptide binding]; other site 266835001092 active site pocket [active] 266835001093 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 266835001094 Predicted aspartyl protease [General function prediction only]; Region: COG3577 266835001095 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 266835001096 catalytic motif [active] 266835001097 Catalytic residue [active] 266835001098 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 266835001099 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 266835001100 FMN binding site [chemical binding]; other site 266835001101 active site 266835001102 catalytic residues [active] 266835001103 substrate binding site [chemical binding]; other site 266835001104 Peptidase M4 family containing mostly uncharacterized proteins; Region: M4_uncharacterized; cd09598 266835001105 Zn binding site [ion binding]; other site 266835001106 Uncharacterized conserved protein [Function unknown]; Region: COG3482 266835001107 Uncharacterized conserved protein [Function unknown]; Region: COG1944; cl09146 266835001108 YcaO-like family; Region: YcaO; pfam02624 266835001109 cyclase homology domain; Region: CHD; cd07302 266835001110 nucleotidyl binding site; other site 266835001111 metal binding site [ion binding]; metal-binding site 266835001112 dimer interface [polypeptide binding]; other site 266835001113 Predicted ATPase [General function prediction only]; Region: COG3899 266835001114 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835001115 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835001116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835001117 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266835001118 active site 266835001119 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 266835001120 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266835001121 active site 266835001122 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 266835001123 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 266835001124 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 266835001125 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cd02259 266835001126 putative active site [active] 266835001127 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 266835001128 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835001129 Walker A/P-loop; other site 266835001130 ATP binding site [chemical binding]; other site 266835001131 Q-loop/lid; other site 266835001132 ABC transporter signature motif; other site 266835001133 Walker B; other site 266835001134 D-loop; other site 266835001135 H-loop/switch region; other site 266835001136 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 266835001137 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266835001138 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266835001139 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266835001140 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266835001141 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266835001142 Sel1 repeat; Region: Sel1; cl02723 266835001143 Sel1 repeat; Region: Sel1; cl02723 266835001144 Sel1 repeat; Region: Sel1; cl02723 266835001145 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 266835001146 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 266835001147 Plant ATP synthase F0; Region: YMF19; cl07975 266835001148 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266835001149 Protein of unknown function (DUF982); Region: DUF982; pfam06169 266835001150 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 266835001151 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835001152 Walker A/P-loop; other site 266835001153 ATP binding site [chemical binding]; other site 266835001154 Q-loop/lid; other site 266835001155 ABC transporter signature motif; other site 266835001156 Walker B; other site 266835001157 D-loop; other site 266835001158 H-loop/switch region; other site 266835001159 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835001160 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266835001161 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835001162 Walker A/P-loop; other site 266835001163 ATP binding site [chemical binding]; other site 266835001164 Q-loop/lid; other site 266835001165 ABC transporter signature motif; other site 266835001166 Walker B; other site 266835001167 D-loop; other site 266835001168 H-loop/switch region; other site 266835001169 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835001170 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835001171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835001172 putative PBP binding loops; other site 266835001173 dimer interface [polypeptide binding]; other site 266835001174 ABC-ATPase subunit interface; other site 266835001175 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266835001176 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 266835001177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835001178 dimer interface [polypeptide binding]; other site 266835001179 conserved gate region; other site 266835001180 putative PBP binding loops; other site 266835001181 ABC-ATPase subunit interface; other site 266835001182 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 266835001183 peptide binding site [polypeptide binding]; other site 266835001184 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 266835001185 proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 266835001186 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 266835001187 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 266835001188 interface (dimer of trimers) [polypeptide binding]; other site 266835001189 Substrate-binding/catalytic site; other site 266835001190 Zn-binding sites [ion binding]; other site 266835001191 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266835001192 Helix-turn-helix domains; Region: HTH; cl00088 266835001193 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835001194 dimerization interface [polypeptide binding]; other site 266835001195 Sodium:solute symporter family; Region: SSF; cl00456 266835001196 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 266835001197 CTP synthetase; Validated; Region: pyrG; PRK05380 266835001198 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 266835001199 Catalytic site [active] 266835001200 active site 266835001201 UTP binding site [chemical binding]; other site 266835001202 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 266835001203 active site 266835001204 putative oxyanion hole; other site 266835001205 catalytic triad [active] 266835001206 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 266835001207 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 266835001208 substrate binding site [chemical binding]; other site 266835001209 dimer interface [polypeptide binding]; other site 266835001210 catalytic triad [active] 266835001211 SurA N-terminal domain; Region: SurA_N_3; cl07813 266835001212 PPIC-type PPIASE domain; Region: Rotamase; cl08278 266835001213 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 266835001214 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 266835001215 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 266835001216 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 266835001217 active site 266835001218 ribulose/triose binding site [chemical binding]; other site 266835001219 phosphate binding site [ion binding]; other site 266835001220 substrate (anthranilate) binding pocket [chemical binding]; other site 266835001221 product (indole) binding pocket [chemical binding]; other site 266835001222 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 266835001223 trimer interface [polypeptide binding]; other site 266835001224 dimer interface [polypeptide binding]; other site 266835001225 putative active site [active] 266835001226 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 266835001227 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 266835001228 dimer interface [polypeptide binding]; other site 266835001229 putative functional site; other site 266835001230 putative MPT binding site; other site 266835001231 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 266835001232 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 266835001233 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 266835001234 AMP-binding enzyme; Region: AMP-binding; cl15778 266835001235 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266835001236 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 266835001237 kynureninase; Region: kynureninase; TIGR01814 266835001238 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266835001239 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266835001240 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835001241 catalytic residue [active] 266835001242 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 266835001243 TM-ABC transporter signature motif; other site 266835001244 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 266835001245 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835001246 Walker A/P-loop; other site 266835001247 ATP binding site [chemical binding]; other site 266835001248 Q-loop/lid; other site 266835001249 ABC transporter signature motif; other site 266835001250 Walker B; other site 266835001251 D-loop; other site 266835001252 H-loop/switch region; other site 266835001253 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 266835001254 zinc binding site [ion binding]; other site 266835001255 putative ligand binding site [chemical binding]; other site 266835001256 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835001257 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835001258 DNA-binding site [nucleotide binding]; DNA binding site 266835001259 FCD domain; Region: FCD; cl11656 266835001260 LexA repressor; Validated; Region: PRK00215 266835001261 Helix-turn-helix domains; Region: HTH; cl00088 266835001262 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 266835001263 Catalytic site [active] 266835001264 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 266835001265 Competence protein; Region: Competence; cl00471 266835001266 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 266835001267 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266835001268 active site 266835001269 HIGH motif; other site 266835001270 nucleotide binding site [chemical binding]; other site 266835001271 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 266835001272 active site 266835001273 KMSKS motif; other site 266835001274 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 266835001275 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 266835001276 dimer interface [polypeptide binding]; other site 266835001277 active site 266835001278 citrylCoA binding site [chemical binding]; other site 266835001279 NADH binding [chemical binding]; other site 266835001280 cationic pore residues; other site 266835001281 oxalacetate/citrate binding site [chemical binding]; other site 266835001282 coenzyme A binding site [chemical binding]; other site 266835001283 catalytic triad [active] 266835001284 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 266835001285 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 266835001286 Protein of unknown function (DUF1009); Region: DUF1009; cl09182 266835001287 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 266835001288 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 266835001289 active site 266835001290 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 266835001291 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 266835001292 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 266835001293 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 266835001294 trimer interface [polypeptide binding]; other site 266835001295 active site 266835001296 UDP-GlcNAc binding site [chemical binding]; other site 266835001297 lipid binding site [chemical binding]; lipid-binding site 266835001298 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 266835001299 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 266835001300 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 266835001301 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 266835001302 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 266835001303 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 266835001304 Surface antigen; Region: Bac_surface_Ag; cl03097 266835001305 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 266835001306 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 266835001307 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 266835001308 protein binding site [polypeptide binding]; other site 266835001309 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 266835001310 putative substrate binding region [chemical binding]; other site 266835001311 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 266835001312 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 266835001313 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 266835001314 catalytic residue [active] 266835001315 putative FPP diphosphate binding site; other site 266835001316 putative FPP binding hydrophobic cleft; other site 266835001317 dimer interface [polypeptide binding]; other site 266835001318 putative IPP diphosphate binding site; other site 266835001319 ribosome recycling factor; Reviewed; Region: frr; PRK00083 266835001320 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 266835001321 hinge region; other site 266835001322 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 266835001323 putative nucleotide binding site [chemical binding]; other site 266835001324 uridine monophosphate binding site [chemical binding]; other site 266835001325 homohexameric interface [polypeptide binding]; other site 266835001326 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 266835001327 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835001328 active site 266835001329 catalytic tetrad [active] 266835001330 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266835001331 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835001332 Helix-turn-helix domains; Region: HTH; cl00088 266835001333 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 266835001334 putative effector binding pocket; other site 266835001335 putative dimerization interface [polypeptide binding]; other site 266835001336 elongation factor Ts; Provisional; Region: tsf; PRK09377 266835001337 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 266835001338 Elongation factor TS; Region: EF_TS; pfam00889 266835001339 Elongation factor TS; Region: EF_TS; pfam00889 266835001340 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 266835001341 rRNA interaction site [nucleotide binding]; other site 266835001342 S8 interaction site; other site 266835001343 putative laminin-1 binding site; other site 266835001344 LysE type translocator; Region: LysE; cl00565 266835001345 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 266835001346 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 266835001347 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 266835001348 homotrimer interaction site [polypeptide binding]; other site 266835001349 putative active site [active] 266835001350 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585 266835001351 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 266835001352 putative active site [active] 266835001353 catalytic site [active] 266835001354 putative metal binding site [ion binding]; other site 266835001355 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835001356 Protein of unknown function, DUF482; Region: DUF482; pfam04339 266835001357 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 266835001358 HIT family signature motif; other site 266835001359 catalytic residue [active] 266835001360 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 266835001361 Clp amino terminal domain; Region: Clp_N; pfam02861 266835001362 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835001363 Walker A motif; other site 266835001364 ATP binding site [chemical binding]; other site 266835001365 Walker B motif; other site 266835001366 arginine finger; other site 266835001367 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835001368 Walker A motif; other site 266835001369 ATP binding site [chemical binding]; other site 266835001370 Walker B motif; other site 266835001371 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 266835001372 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 266835001373 Phasin protein; Region: Phasin_2; cl11491 266835001374 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 266835001375 Sporulation related domain; Region: SPOR; cl10051 266835001376 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266835001377 HSP70 interaction site [polypeptide binding]; other site 266835001378 Protein of unknown function (DUF1489); Region: DUF1489; cl11570 266835001379 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 266835001380 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 266835001381 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 266835001382 Protein of unknown function, DUF599; Region: DUF599; cl01575 266835001383 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 266835001384 putative active site [active] 266835001385 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 266835001386 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 266835001387 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835001388 Coenzyme A binding pocket [chemical binding]; other site 266835001389 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 266835001390 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266835001391 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 266835001392 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 266835001393 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266835001394 FAD binding site [chemical binding]; other site 266835001395 substrate binding site [chemical binding]; other site 266835001396 catalytic residues [active] 266835001397 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 266835001398 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 266835001399 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835001400 dihydroorotase; Validated; Region: PRK09059 266835001401 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266835001402 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 266835001403 active site 266835001404 Domain of unknown function (DUF205); Region: DUF205; cl00410 266835001405 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 266835001406 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 266835001407 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266835001408 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 266835001409 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 266835001410 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 266835001411 active site 266835001412 homotetramer interface [polypeptide binding]; other site 266835001413 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 266835001414 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 266835001415 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266835001416 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 266835001417 putative ADP-binding pocket [chemical binding]; other site 266835001418 OpgC protein; Region: OpgC_C; cl00792 266835001419 Acyltransferase family; Region: Acyl_transf_3; pfam01757 266835001420 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 266835001421 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266835001422 BA14K-like protein; Region: BA14K; pfam07886 266835001423 glycerol kinase; Provisional; Region: glpK; PRK00047 266835001424 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 266835001425 N- and C-terminal domain interface [polypeptide binding]; other site 266835001426 active site 266835001427 MgATP binding site [chemical binding]; other site 266835001428 catalytic site [active] 266835001429 metal binding site [ion binding]; metal-binding site 266835001430 glycerol binding site [chemical binding]; other site 266835001431 homotetramer interface [polypeptide binding]; other site 266835001432 homodimer interface [polypeptide binding]; other site 266835001433 FBP binding site [chemical binding]; other site 266835001434 protein IIAGlc interface [polypeptide binding]; other site 266835001435 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835001436 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835001437 Predicted small integral membrane protein (DUF2160); Region: DUF2160; cl02294 266835001438 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835001439 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835001440 dimer interface [polypeptide binding]; other site 266835001441 conserved gate region; other site 266835001442 putative PBP binding loops; other site 266835001443 ABC-ATPase subunit interface; other site 266835001444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835001445 dimer interface [polypeptide binding]; other site 266835001446 conserved gate region; other site 266835001447 putative PBP binding loops; other site 266835001448 ABC-ATPase subunit interface; other site 266835001449 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266835001450 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 266835001451 Walker A/P-loop; other site 266835001452 ATP binding site [chemical binding]; other site 266835001453 Q-loop/lid; other site 266835001454 ABC transporter signature motif; other site 266835001455 Walker B; other site 266835001456 D-loop; other site 266835001457 H-loop/switch region; other site 266835001458 TOBE domain; Region: TOBE_2; cl01440 266835001459 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266835001460 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 266835001461 Walker A/P-loop; other site 266835001462 ATP binding site [chemical binding]; other site 266835001463 Q-loop/lid; other site 266835001464 ABC transporter signature motif; other site 266835001465 Walker B; other site 266835001466 D-loop; other site 266835001467 H-loop/switch region; other site 266835001468 TOBE domain; Region: TOBE_2; cl01440 266835001469 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 266835001470 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835001471 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 266835001472 Helix-turn-helix domains; Region: HTH; cl00088 266835001473 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 266835001474 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 266835001475 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266835001476 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835001477 catalytic residue [active] 266835001478 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 266835001479 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 266835001480 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 266835001481 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 266835001482 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 266835001483 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 266835001484 Uncharacterized conserved protein [Function unknown]; Region: COG2308 266835001485 Domain of unknown function (DUF404); Region: DUF404; pfam04169 266835001486 Domain of unknown function (DUF407); Region: DUF407; pfam04174 266835001487 Helix-turn-helix domains; Region: HTH; cl00088 266835001488 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 266835001489 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 266835001490 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 266835001491 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 266835001492 Protein of unknown function, DUF606; Region: DUF606; cl01273 266835001493 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 266835001494 active site 266835001495 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 266835001496 active site 266835001497 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 266835001498 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 266835001499 active site 266835001500 (T/H)XGH motif; other site 266835001501 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 266835001502 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 266835001503 CAP-like domain; other site 266835001504 active site 266835001505 primary dimer interface [polypeptide binding]; other site 266835001506 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266835001507 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266835001508 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266835001509 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266835001510 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266835001511 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266835001512 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 266835001513 Permease family; Region: Xan_ur_permease; cl00967 266835001514 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 266835001515 Putative ParB-like nuclease; Region: ParBc_2; cl01772 266835001516 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266835001517 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835001518 OpgC protein; Region: OpgC_C; cl00792 266835001519 Acyltransferase family; Region: Acyl_transf_3; pfam01757 266835001520 MarC family integral membrane protein; Region: MarC; cl00919 266835001521 OsmC-like protein; Region: OsmC; cl00767 266835001522 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 266835001523 dimer interface [polypeptide binding]; other site 266835001524 ssDNA binding site [nucleotide binding]; other site 266835001525 tetramer (dimer of dimers) interface [polypeptide binding]; other site 266835001526 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835001527 dimerization interface [polypeptide binding]; other site 266835001528 putative DNA binding site [nucleotide binding]; other site 266835001529 putative Zn2+ binding site [ion binding]; other site 266835001530 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 266835001531 putative hydrophobic ligand binding site [chemical binding]; other site 266835001532 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 266835001533 oligomer interface [polypeptide binding]; other site 266835001534 active site residues [active] 266835001535 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 266835001536 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 266835001537 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 266835001538 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 266835001539 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835001540 Coenzyme A binding pocket [chemical binding]; other site 266835001541 Protein of unknown function DUF72; Region: DUF72; cl00777 266835001542 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835001543 metal binding site [ion binding]; metal-binding site 266835001544 active site 266835001545 I-site; other site 266835001546 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 266835001547 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 266835001548 Walker A/P-loop; other site 266835001549 ATP binding site [chemical binding]; other site 266835001550 Q-loop/lid; other site 266835001551 ABC transporter signature motif; other site 266835001552 Walker B; other site 266835001553 D-loop; other site 266835001554 H-loop/switch region; other site 266835001555 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 266835001556 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 266835001557 Walker A/P-loop; other site 266835001558 ATP binding site [chemical binding]; other site 266835001559 Q-loop/lid; other site 266835001560 ABC transporter signature motif; other site 266835001561 Walker B; other site 266835001562 D-loop; other site 266835001563 H-loop/switch region; other site 266835001564 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266835001565 TM-ABC transporter signature motif; other site 266835001566 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266835001567 TM-ABC transporter signature motif; other site 266835001568 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266835001569 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 266835001570 putative ligand binding site [chemical binding]; other site 266835001571 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 266835001572 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 266835001573 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 266835001574 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 266835001575 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 266835001576 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835001577 dimer interface [polypeptide binding]; other site 266835001578 phosphorylation site [posttranslational modification] 266835001579 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835001580 ATP binding site [chemical binding]; other site 266835001581 Mg2+ binding site [ion binding]; other site 266835001582 G-X-G motif; other site 266835001583 Response regulator receiver domain; Region: Response_reg; pfam00072 266835001584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835001585 active site 266835001586 phosphorylation site [posttranslational modification] 266835001587 intermolecular recognition site; other site 266835001588 dimerization interface [polypeptide binding]; other site 266835001589 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 266835001590 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266835001591 catalytic core [active] 266835001592 YcjX-like family, DUF463; Region: DUF463; cl01193 266835001593 Predicted membrane protein [Function unknown]; Region: COG3768 266835001594 Domain of unknown function (DUF697); Region: DUF697; cl12064 266835001595 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266835001596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 266835001597 Cupin domain; Region: Cupin_2; cl09118 266835001598 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835001599 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266835001600 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835001601 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 266835001602 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 266835001603 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835001604 Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561 266835001605 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 266835001606 catalytic center binding site [active] 266835001607 ATP binding site [chemical binding]; other site 266835001608 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 266835001609 homooctamer interface [polypeptide binding]; other site 266835001610 active site 266835001611 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 266835001612 dihydropteroate synthase; Region: DHPS; TIGR01496 266835001613 substrate binding pocket [chemical binding]; other site 266835001614 dimer interface [polypeptide binding]; other site 266835001615 inhibitor binding site; inhibition site 266835001616 Bacterial protein of unknown function (DUF922); Region: DUF922; cl02415 266835001617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835001618 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266835001619 putative substrate translocation pore; other site 266835001620 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 266835001621 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835001622 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835001623 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 266835001624 MAEBL; Provisional; Region: PTZ00121 266835001625 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 266835001626 Protein of unknown function (DUF330); Region: DUF330; cl01135 266835001627 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 266835001628 mce related protein; Region: MCE; pfam02470 266835001629 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 266835001630 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 266835001631 Walker A/P-loop; other site 266835001632 ATP binding site [chemical binding]; other site 266835001633 Q-loop/lid; other site 266835001634 ABC transporter signature motif; other site 266835001635 Walker B; other site 266835001636 D-loop; other site 266835001637 H-loop/switch region; other site 266835001638 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 266835001639 Permease; Region: Permease; cl00510 266835001640 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 266835001641 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 266835001642 active site 266835001643 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 266835001644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835001645 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 266835001646 putative active site [active] 266835001647 putative metal binding site [ion binding]; other site 266835001648 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 266835001649 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266835001650 putative NAD(P) binding site [chemical binding]; other site 266835001651 putative active site [active] 266835001652 malic enzyme; Reviewed; Region: PRK12862 266835001653 Malic enzyme, N-terminal domain; Region: malic; pfam00390 266835001654 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 266835001655 putative NAD(P) binding site [chemical binding]; other site 266835001656 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 266835001657 Surface antigen; Region: Surface_Ag_2; cl01155 266835001658 Protein of unknown function (DUF2865); Region: DUF2865; pfam11064 266835001659 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 266835001660 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 266835001661 HIGH motif; other site 266835001662 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 266835001663 active site 266835001664 KMSKS motif; other site 266835001665 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266835001666 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 266835001667 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 266835001668 Walker A/P-loop; other site 266835001669 ATP binding site [chemical binding]; other site 266835001670 Q-loop/lid; other site 266835001671 ABC transporter signature motif; other site 266835001672 Walker B; other site 266835001673 D-loop; other site 266835001674 H-loop/switch region; other site 266835001675 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835001676 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835001677 Coenzyme A binding pocket [chemical binding]; other site 266835001678 NAD synthetase; Provisional; Region: PRK13981 266835001679 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 266835001680 multimer interface [polypeptide binding]; other site 266835001681 active site 266835001682 catalytic triad [active] 266835001683 protein interface 1 [polypeptide binding]; other site 266835001684 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 266835001685 homodimer interface [polypeptide binding]; other site 266835001686 NAD binding pocket [chemical binding]; other site 266835001687 ATP binding pocket [chemical binding]; other site 266835001688 Mg binding site [ion binding]; other site 266835001689 active-site loop [active] 266835001690 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 266835001691 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 266835001692 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 266835001693 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 266835001694 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 266835001695 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 266835001696 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835001697 metal binding site [ion binding]; metal-binding site 266835001698 active site 266835001699 I-site; other site 266835001700 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 266835001701 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 266835001702 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 266835001703 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266835001704 ATP binding site [chemical binding]; other site 266835001705 putative Mg++ binding site [ion binding]; other site 266835001706 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266835001707 nucleotide binding region [chemical binding]; other site 266835001708 ATP-binding site [chemical binding]; other site 266835001709 TRCF domain; Region: TRCF; cl04088 266835001710 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 266835001711 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 266835001712 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 266835001713 generic binding surface II; other site 266835001714 ssDNA binding site; other site 266835001715 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266835001716 ATP binding site [chemical binding]; other site 266835001717 putative Mg++ binding site [ion binding]; other site 266835001718 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266835001719 nucleotide binding region [chemical binding]; other site 266835001720 ATP-binding site [chemical binding]; other site 266835001721 Protein of unknown function (DUF502); Region: DUF502; cl01107 266835001722 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 266835001723 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 266835001724 glutaminase active site [active] 266835001725 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 266835001726 dimer interface [polypeptide binding]; other site 266835001727 active site 266835001728 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 266835001729 dimer interface [polypeptide binding]; other site 266835001730 active site 266835001731 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 266835001732 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 266835001733 Substrate binding site; other site 266835001734 Mg++ binding site; other site 266835001735 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 266835001736 active site 266835001737 substrate binding site [chemical binding]; other site 266835001738 CoA binding site [chemical binding]; other site 266835001739 LysE type translocator; Region: LysE; cl00565 266835001740 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 266835001741 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 266835001742 active site 266835001743 interdomain interaction site; other site 266835001744 putative metal-binding site [ion binding]; other site 266835001745 nucleotide binding site [chemical binding]; other site 266835001746 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 266835001747 domain I; other site 266835001748 DNA binding groove [nucleotide binding] 266835001749 phosphate binding site [ion binding]; other site 266835001750 domain II; other site 266835001751 domain III; other site 266835001752 nucleotide binding site [chemical binding]; other site 266835001753 catalytic site [active] 266835001754 domain IV; other site 266835001755 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 266835001756 ribonuclease R; Region: RNase_R; TIGR02063 266835001757 RNB domain; Region: RNB; pfam00773 266835001758 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 266835001759 RNA binding site [nucleotide binding]; other site 266835001760 Protein of unknown function (DUF983); Region: DUF983; cl02211 266835001761 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 266835001762 nudix motif; other site 266835001763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835001764 putative substrate translocation pore; other site 266835001765 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835001766 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 266835001767 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 266835001768 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266835001769 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 266835001770 Walker A/P-loop; other site 266835001771 ATP binding site [chemical binding]; other site 266835001772 Q-loop/lid; other site 266835001773 ABC transporter signature motif; other site 266835001774 Walker B; other site 266835001775 D-loop; other site 266835001776 H-loop/switch region; other site 266835001777 TOBE domain; Region: TOBE_2; cl01440 266835001778 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835001779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835001780 dimer interface [polypeptide binding]; other site 266835001781 conserved gate region; other site 266835001782 putative PBP binding loops; other site 266835001783 ABC-ATPase subunit interface; other site 266835001784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835001785 dimer interface [polypeptide binding]; other site 266835001786 conserved gate region; other site 266835001787 putative PBP binding loops; other site 266835001788 ABC-ATPase subunit interface; other site 266835001789 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835001790 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835001791 hypothetical protein; Provisional; Region: PRK05968 266835001792 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 266835001793 homodimer interface [polypeptide binding]; other site 266835001794 substrate-cofactor binding pocket; other site 266835001795 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835001796 catalytic residue [active] 266835001797 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266835001798 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835001799 DNA-binding site [nucleotide binding]; DNA binding site 266835001800 FCD domain; Region: FCD; cl11656 266835001801 hypothetical protein; Provisional; Region: PRK06834 266835001802 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835001803 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835001804 Poly A polymerase head domain; Region: PolyA_pol; cl14657 266835001805 response regulator PleD; Reviewed; Region: pleD; PRK09581 266835001806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835001807 active site 266835001808 phosphorylation site [posttranslational modification] 266835001809 intermolecular recognition site; other site 266835001810 dimerization interface [polypeptide binding]; other site 266835001811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 266835001812 active site 266835001813 phosphorylation site [posttranslational modification] 266835001814 intermolecular recognition site; other site 266835001815 dimerization interface [polypeptide binding]; other site 266835001816 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835001817 metal binding site [ion binding]; metal-binding site 266835001818 active site 266835001819 I-site; other site 266835001820 Response regulator receiver domain; Region: Response_reg; pfam00072 266835001821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835001822 active site 266835001823 phosphorylation site [posttranslational modification] 266835001824 intermolecular recognition site; other site 266835001825 dimerization interface [polypeptide binding]; other site 266835001826 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 266835001827 hypothetical protein; Provisional; Region: 30.2; PHA02597 266835001828 DNA polymerase IV; Provisional; Region: PRK02794 266835001829 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 266835001830 active site 266835001831 DNA binding site [nucleotide binding] 266835001832 EamA-like transporter family; Region: EamA; cl01037 266835001833 Ion channel; Region: Ion_trans_2; cl11596 266835001834 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 266835001835 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 266835001836 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 266835001837 generic binding surface II; other site 266835001838 generic binding surface I; other site 266835001839 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 266835001840 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266835001841 ATP-grasp domain; Region: ATP-grasp_4; cl03087 266835001842 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 266835001843 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266835001844 carboxyltransferase (CT) interaction site; other site 266835001845 biotinylation site [posttranslational modification]; other site 266835001846 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 266835001847 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 266835001848 substrate binding site [chemical binding]; other site 266835001849 catalytic Zn binding site [ion binding]; other site 266835001850 NAD binding site [chemical binding]; other site 266835001851 structural Zn binding site [ion binding]; other site 266835001852 dimer interface [polypeptide binding]; other site 266835001853 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 266835001854 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 266835001855 Protein of unknown function (DUF1345); Region: DUF1345; cl01753 266835001856 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 266835001857 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 266835001858 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 266835001859 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 266835001860 Moco binding site; other site 266835001861 metal coordination site [ion binding]; other site 266835001862 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 266835001863 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835001864 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 266835001865 lipoyl attachment site [posttranslational modification]; other site 266835001866 glycine dehydrogenase; Provisional; Region: PRK05367 266835001867 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 266835001868 tetramer interface [polypeptide binding]; other site 266835001869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835001870 catalytic residue [active] 266835001871 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266835001872 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835001873 catalytic residue [active] 266835001874 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835001875 metal binding site [ion binding]; metal-binding site 266835001876 active site 266835001877 I-site; other site 266835001878 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835001879 binding surface 266835001880 TPR motif; other site 266835001881 LytTr DNA-binding domain; Region: LytTR; cl04498 266835001882 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 266835001883 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 266835001884 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 266835001885 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 266835001886 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 266835001887 ATP binding site [chemical binding]; other site 266835001888 Walker A motif; other site 266835001889 hexamer interface [polypeptide binding]; other site 266835001890 Walker B motif; other site 266835001891 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 266835001892 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835001893 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 266835001894 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 266835001895 BON domain; Region: BON; cl02771 266835001896 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 266835001897 SAF domain; Region: SAF; cl00555 266835001898 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 266835001899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 266835001900 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 266835001901 anchoring element; other site 266835001902 dimer interface [polypeptide binding]; other site 266835001903 ATP binding site [chemical binding]; other site 266835001904 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 266835001905 active site 266835001906 metal binding site [ion binding]; metal-binding site 266835001907 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 266835001908 Fusaric acid resistance protein family; Region: FUSC; pfam04632 266835001909 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 266835001910 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 266835001911 putative active site [active] 266835001912 putative catalytic site [active] 266835001913 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 266835001914 voltage-gated potassium channel; Provisional; Region: PRK10537 266835001915 Protein of unknown function (DUF1012); Region: DUF1012; pfam06241 266835001916 Phospholipid methyltransferase; Region: PEMT; cl00763 266835001917 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835001918 Helix-turn-helix domains; Region: HTH; cl00088 266835001919 Flavin Reductases; Region: FlaRed; cl00801 266835001920 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 266835001921 putative FMN binding site [chemical binding]; other site 266835001922 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 266835001923 putative acyl-acceptor binding pocket; other site 266835001924 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 266835001925 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 266835001926 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 266835001927 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 266835001928 active site 266835001929 dimer interface [polypeptide binding]; other site 266835001930 motif 1; other site 266835001931 motif 2; other site 266835001932 motif 3; other site 266835001933 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 266835001934 anticodon binding site; other site 266835001935 Leucine carboxyl methyltransferase; Region: LCM; cl01306 266835001936 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 266835001937 Domain of unknown function DUF37; Region: DUF37; cl00506 266835001938 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266835001939 Helix-turn-helix domains; Region: HTH; cl00088 266835001940 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266835001941 dimerization interface [polypeptide binding]; other site 266835001942 substrate binding pocket [chemical binding]; other site 266835001943 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 266835001944 trimerization site [polypeptide binding]; other site 266835001945 active site 266835001946 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 266835001947 homodecamer interface [polypeptide binding]; other site 266835001948 GTP cyclohydrolase I; Provisional; Region: PLN03044 266835001949 active site 266835001950 putative catalytic site residues [active] 266835001951 zinc binding site [ion binding]; other site 266835001952 GTP-CH-I/GFRP interaction surface; other site 266835001953 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 266835001954 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 266835001955 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 266835001956 active site 266835001957 nucleophile elbow; other site 266835001958 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 266835001959 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 266835001960 DHH family; Region: DHH; pfam01368 266835001961 DHHA1 domain; Region: DHHA1; pfam02272 266835001962 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 266835001963 putative active site [active] 266835001964 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 266835001965 homoserine dehydrogenase; Provisional; Region: PRK06349 266835001966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835001967 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 266835001968 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 266835001969 aminotransferase; Validated; Region: PRK09148 266835001970 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835001971 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835001972 homodimer interface [polypeptide binding]; other site 266835001973 catalytic residue [active] 266835001974 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 266835001975 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 266835001976 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 266835001977 Peptidase M15; Region: Peptidase_M15_3; cl01194 266835001978 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266835001979 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 266835001980 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266835001981 HSP70 interaction site [polypeptide binding]; other site 266835001982 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 266835001983 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 266835001984 TadE-like protein; Region: TadE; cl10688 266835001985 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 266835001986 Autotransporter beta-domain; Region: Autotransporter; cl02365 266835001987 Protein of unknown function (DUF982); Region: DUF982; pfam06169 266835001988 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 266835001989 active site 266835001990 hypothetical protein; Reviewed; Region: PRK00024 266835001991 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 266835001992 MPN+ (JAMM) motif; other site 266835001993 Zinc-binding site [ion binding]; other site 266835001994 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 266835001995 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266835001996 DNA binding site [nucleotide binding] 266835001997 Int/Topo IB signature motif; other site 266835001998 active site 266835001999 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835002000 non-specific DNA binding site [nucleotide binding]; other site 266835002001 salt bridge; other site 266835002002 sequence-specific DNA binding site [nucleotide binding]; other site 266835002003 OpgC protein; Region: OpgC_C; cl00792 266835002004 OpgC protein; Region: OpgC_C; cl00792 266835002005 conjugal transfer relaxase TraA; Provisional; Region: PRK13889 266835002006 MobA/MobL family; Region: MobA_MobL; pfam03389 266835002007 Conjugal transfer protein TraD; Region: TraD; cl05753 266835002008 allantoate amidohydrolase; Reviewed; Region: PRK12892 266835002009 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 266835002010 active site 266835002011 metal binding site [ion binding]; metal-binding site 266835002012 dimer interface [polypeptide binding]; other site 266835002013 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835002014 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 266835002015 [2Fe-2S] cluster binding site [ion binding]; other site 266835002016 cytochrome b; Provisional; Region: CYTB; MTH00119 266835002017 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 266835002018 Qi binding site; other site 266835002019 intrachain domain interface; other site 266835002020 interchain domain interface [polypeptide binding]; other site 266835002021 heme bH binding site [chemical binding]; other site 266835002022 heme bL binding site [chemical binding]; other site 266835002023 Qo binding site; other site 266835002024 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 266835002025 interchain domain interface [polypeptide binding]; other site 266835002026 intrachain domain interface; other site 266835002027 Qi binding site; other site 266835002028 Qo binding site; other site 266835002029 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266835002030 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266835002031 ligand binding site [chemical binding]; other site 266835002032 flexible hinge region; other site 266835002033 Pirin-related protein [General function prediction only]; Region: COG1741 266835002034 Cupin domain; Region: Cupin_2; cl09118 266835002035 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 266835002036 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 266835002037 histidine kinase; Provisional; Region: PRK13557 266835002038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835002039 ATP binding site [chemical binding]; other site 266835002040 Mg2+ binding site [ion binding]; other site 266835002041 G-X-G motif; other site 266835002042 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 266835002043 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835002044 NAD(P) binding site [chemical binding]; other site 266835002045 active site 266835002046 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835002047 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835002048 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835002049 Cupin domain; Region: Cupin_2; cl09118 266835002050 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_6; cd04619 266835002051 FOG: CBS domain [General function prediction only]; Region: COG0517 266835002052 glutathionine S-transferase; Provisional; Region: PRK10542 266835002053 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 266835002054 C-terminal domain interface [polypeptide binding]; other site 266835002055 GSH binding site (G-site) [chemical binding]; other site 266835002056 dimer interface [polypeptide binding]; other site 266835002057 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 266835002058 dimer interface [polypeptide binding]; other site 266835002059 N-terminal domain interface [polypeptide binding]; other site 266835002060 substrate binding pocket (H-site) [chemical binding]; other site 266835002061 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 266835002062 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 266835002063 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 266835002064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835002065 active site 266835002066 phosphorylation site [posttranslational modification] 266835002067 intermolecular recognition site; other site 266835002068 dimerization interface [polypeptide binding]; other site 266835002069 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835002070 DNA binding residues [nucleotide binding] 266835002071 dimerization interface [polypeptide binding]; other site 266835002072 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 266835002073 MASE1; Region: MASE1; pfam05231 266835002074 PAS fold; Region: PAS; pfam00989 266835002075 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835002076 putative active site [active] 266835002077 heme pocket [chemical binding]; other site 266835002078 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835002079 putative active site [active] 266835002080 heme pocket [chemical binding]; other site 266835002081 PAS domain S-box; Region: sensory_box; TIGR00229 266835002082 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835002083 putative active site [active] 266835002084 heme pocket [chemical binding]; other site 266835002085 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 266835002086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835002087 ATP binding site [chemical binding]; other site 266835002088 Mg2+ binding site [ion binding]; other site 266835002089 G-X-G motif; other site 266835002090 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 266835002091 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 266835002092 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266835002093 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835002094 Walker A/P-loop; other site 266835002095 ATP binding site [chemical binding]; other site 266835002096 Q-loop/lid; other site 266835002097 ABC transporter signature motif; other site 266835002098 Walker B; other site 266835002099 D-loop; other site 266835002100 H-loop/switch region; other site 266835002101 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835002102 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 266835002103 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835002104 Walker A/P-loop; other site 266835002105 ATP binding site [chemical binding]; other site 266835002106 Q-loop/lid; other site 266835002107 ABC transporter signature motif; other site 266835002108 Walker B; other site 266835002109 D-loop; other site 266835002110 H-loop/switch region; other site 266835002111 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835002112 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266835002113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835002114 dimer interface [polypeptide binding]; other site 266835002115 conserved gate region; other site 266835002116 putative PBP binding loops; other site 266835002117 ABC-ATPase subunit interface; other site 266835002118 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835002119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835002120 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835002121 PAS fold; Region: PAS_3; pfam08447 266835002122 putative active site [active] 266835002123 heme pocket [chemical binding]; other site 266835002124 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835002125 PAS fold; Region: PAS_3; pfam08447 266835002126 putative active site [active] 266835002127 heme pocket [chemical binding]; other site 266835002128 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 266835002129 dimer interface [polypeptide binding]; other site 266835002130 phosphorylation site [posttranslational modification] 266835002131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835002132 ATP binding site [chemical binding]; other site 266835002133 Mg2+ binding site [ion binding]; other site 266835002134 G-X-G motif; other site 266835002135 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 266835002136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835002137 active site 266835002138 phosphorylation site [posttranslational modification] 266835002139 intermolecular recognition site; other site 266835002140 dimerization interface [polypeptide binding]; other site 266835002141 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835002142 DNA binding residues [nucleotide binding] 266835002143 dimerization interface [polypeptide binding]; other site 266835002144 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 266835002145 heme-binding site [chemical binding]; other site 266835002146 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 266835002147 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835002148 nucleophilic elbow; other site 266835002149 catalytic triad; other site 266835002150 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266835002151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835002152 putative substrate translocation pore; other site 266835002153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835002154 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 266835002155 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266835002156 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266835002157 histidine kinase; Provisional; Region: PRK13557 266835002158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835002159 ATP binding site [chemical binding]; other site 266835002160 Mg2+ binding site [ion binding]; other site 266835002161 G-X-G motif; other site 266835002162 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266835002163 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835002164 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835002165 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 266835002166 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 266835002167 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266835002168 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 266835002169 Walker A/P-loop; other site 266835002170 ATP binding site [chemical binding]; other site 266835002171 Q-loop/lid; other site 266835002172 ABC transporter signature motif; other site 266835002173 Walker B; other site 266835002174 D-loop; other site 266835002175 H-loop/switch region; other site 266835002176 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835002177 TM-ABC transporter signature motif; other site 266835002178 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 266835002179 putative ligand binding site [chemical binding]; other site 266835002180 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266835002181 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835002182 DNA binding site [nucleotide binding] 266835002183 domain linker motif; other site 266835002184 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 266835002185 putative ligand binding site [chemical binding]; other site 266835002186 putative dimerization interface [polypeptide binding]; other site 266835002187 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266835002188 choline dehydrogenase; Validated; Region: PRK02106 266835002189 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835002190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835002191 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266835002192 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 266835002193 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835002194 substrate binding site [chemical binding]; other site 266835002195 oxyanion hole (OAH) forming residues; other site 266835002196 trimer interface [polypeptide binding]; other site 266835002197 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266835002198 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 266835002199 inhibitor site; inhibition site 266835002200 active site 266835002201 dimer interface [polypeptide binding]; other site 266835002202 catalytic residue [active] 266835002203 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 266835002204 Periplasmic binding domain of two-component sensor kinase signaling systems; Region: PBP1_sensor_kinase_like; cd06308 266835002205 putative ligand binding site [chemical binding]; other site 266835002206 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835002207 TM-ABC transporter signature motif; other site 266835002208 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266835002209 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 266835002210 active site 266835002211 motif I; other site 266835002212 motif II; other site 266835002213 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835002214 Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118 266835002215 NAD(P) binding site [chemical binding]; other site 266835002216 catalytic residues [active] 266835002217 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835002218 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835002219 Walker A/P-loop; other site 266835002220 ATP binding site [chemical binding]; other site 266835002221 Q-loop/lid; other site 266835002222 ABC transporter signature motif; other site 266835002223 Walker B; other site 266835002224 D-loop; other site 266835002225 H-loop/switch region; other site 266835002226 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 266835002227 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 266835002228 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 1, classical (c) SDR; Region: BKR_1_SDR_c; cd05337 266835002229 putative NAD(P) binding site [chemical binding]; other site 266835002230 active site 266835002231 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266835002232 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266835002233 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266835002234 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835002235 DNA binding site [nucleotide binding] 266835002236 domain linker motif; other site 266835002237 This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273 266835002238 putative ligand binding site [chemical binding]; other site 266835002239 putative dimerization interface [polypeptide binding]; other site 266835002240 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266835002241 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835002242 cyclase homology domain; Region: CHD; cd07302 266835002243 nucleotidyl binding site; other site 266835002244 metal binding site [ion binding]; metal-binding site 266835002245 dimer interface [polypeptide binding]; other site 266835002246 TolB amino-terminal domain; Region: TolB_N; cl00639 266835002247 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835002248 TPR motif; other site 266835002249 binding surface 266835002250 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835002251 TPR motif; other site 266835002252 binding surface 266835002253 cyclase homology domain; Region: CHD; cd07302 266835002254 nucleotidyl binding site; other site 266835002255 metal binding site [ion binding]; metal-binding site 266835002256 dimer interface [polypeptide binding]; other site 266835002257 TolB amino-terminal domain; Region: TolB_N; cl00639 266835002258 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835002259 TPR motif; other site 266835002260 binding surface 266835002261 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835002262 TPR motif; other site 266835002263 binding surface 266835002264 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 266835002265 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835002266 TPR motif; other site 266835002267 binding surface 266835002268 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 266835002269 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835002270 Predicted transcriptional regulator [Transcription]; Region: COG4957 266835002271 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 266835002272 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 266835002273 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266835002274 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266835002275 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 266835002276 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 266835002277 This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export...; Region: ABCC_Protease_Secretion; cd03246 266835002278 Walker A/P-loop; other site 266835002279 ATP binding site [chemical binding]; other site 266835002280 Q-loop/lid; other site 266835002281 ABC transporter signature motif; other site 266835002282 Walker B; other site 266835002283 D-loop; other site 266835002284 H-loop/switch region; other site 266835002285 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 266835002286 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 266835002287 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 266835002288 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 266835002289 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 266835002290 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 266835002291 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 266835002292 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 266835002293 MPN+ (JAMM) motif; other site 266835002294 Zinc-binding site [ion binding]; other site 266835002295 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 266835002296 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 266835002297 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129 266835002298 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835002299 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266835002300 short chain dehydrogenase; Provisional; Region: PRK12829 266835002301 classical (c) SDRs; Region: SDR_c; cd05233 266835002302 NAD(P) binding site [chemical binding]; other site 266835002303 active site 266835002304 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835002305 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835002306 DNA-binding site [nucleotide binding]; DNA binding site 266835002307 FCD domain; Region: FCD; cl11656 266835002308 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 266835002309 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 266835002310 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 266835002311 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 266835002312 D-pathway; other site 266835002313 Low-spin heme binding site [chemical binding]; other site 266835002314 Putative water exit pathway; other site 266835002315 Binuclear center (active site) [active] 266835002316 K-pathway; other site 266835002317 Putative proton exit pathway; other site 266835002318 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865 266835002319 Subunit I/III interface [polypeptide binding]; other site 266835002320 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864 266835002321 Subunit I/III interface [polypeptide binding]; other site 266835002322 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 266835002323 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 266835002324 putative deacylase active site [active] 266835002325 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 266835002326 UbiA prenyltransferase family; Region: UbiA; cl00337 266835002327 Cytochrome c; Region: Cytochrom_C; cl11414 266835002328 trigger factor; Provisional; Region: tig; PRK01490 266835002329 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 266835002330 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 266835002331 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 266835002332 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835002333 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266835002334 homotrimer interaction site [polypeptide binding]; other site 266835002335 putative active site [active] 266835002336 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 266835002337 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 266835002338 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 266835002339 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 266835002340 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 266835002341 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 266835002342 substrate binding pocket [chemical binding]; other site 266835002343 substrate-Mg2+ binding site; other site 266835002344 aspartate-rich region 1; other site 266835002345 aspartate-rich region 2; other site 266835002346 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 266835002347 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 266835002348 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 266835002349 Protein export membrane protein; Region: SecD_SecF; cl14618 266835002350 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 266835002351 Protein export membrane protein; Region: SecD_SecF; cl14618 266835002352 Preprotein translocase subunit; Region: YajC; cl00806 266835002353 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 266835002354 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835002355 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266835002356 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835002357 atypical (a) SDRs, subgroup 3; Region: SDR_a3; cd05229 266835002358 putative NAD(P) binding site [chemical binding]; other site 266835002359 putative active site [active] 266835002360 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 266835002361 putative peptidoglycan binding site; other site 266835002362 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 266835002363 putative peptidoglycan binding site; other site 266835002364 Peptidase family M23; Region: Peptidase_M23; pfam01551 266835002365 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 266835002366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835002367 S-adenosylmethionine binding site [chemical binding]; other site 266835002368 Survival protein SurE; Region: SurE; cl00448 266835002369 seryl-tRNA synthetase; Provisional; Region: PRK05431 266835002370 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 266835002371 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 266835002372 dimer interface [polypeptide binding]; other site 266835002373 active site 266835002374 motif 1; other site 266835002375 motif 2; other site 266835002376 motif 3; other site 266835002377 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 266835002378 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 266835002379 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 266835002380 ScpA/B protein; Region: ScpA_ScpB; cl00598 266835002381 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 266835002382 Sporulation related domain; Region: SPOR; cl10051 266835002383 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 266835002384 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 266835002385 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 266835002386 active site 266835002387 HIGH motif; other site 266835002388 KMSK motif region; other site 266835002389 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 266835002390 tRNA binding surface [nucleotide binding]; other site 266835002391 anticodon binding site; other site 266835002392 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 266835002393 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 266835002394 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 266835002395 active site 266835002396 metal binding site [ion binding]; metal-binding site 266835002397 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 266835002398 putative phosphate binding site [ion binding]; other site 266835002399 putative catalytic site [active] 266835002400 active site 266835002401 metal binding site A [ion binding]; metal-binding site 266835002402 DNA binding site [nucleotide binding] 266835002403 putative AP binding site [nucleotide binding]; other site 266835002404 putative metal binding site B [ion binding]; other site 266835002405 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266835002406 Sel1 repeat; Region: Sel1; cl02723 266835002407 Sel1 repeat; Region: Sel1; cl02723 266835002408 Dehydratase family; Region: ILVD_EDD; cl00340 266835002409 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488 266835002410 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 266835002411 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 266835002412 HIGH motif; other site 266835002413 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 266835002414 active site 266835002415 KMSKS motif; other site 266835002416 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 266835002417 tRNA binding surface [nucleotide binding]; other site 266835002418 anticodon binding site; other site 266835002419 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 266835002420 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 266835002421 dimer interface [polypeptide binding]; other site 266835002422 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835002423 ligand binding site [chemical binding]; other site 266835002424 Protein of unknown function (DUF2497); Region: DUF2497; cl11534 266835002425 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 266835002426 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 266835002427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835002428 S-adenosylmethionine binding site [chemical binding]; other site 266835002429 Cupin domain; Region: Cupin_2; cl09118 266835002430 Uncharacterized conserved protein [Function unknown]; Region: COG2128 266835002431 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266835002432 CutC family; Region: CutC; cl01218 266835002433 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835002434 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824 266835002435 putative hydrophobic ligand binding site [chemical binding]; other site 266835002436 OpgC protein; Region: OpgC_C; cl00792 266835002437 OpgC protein; Region: OpgC_C; cl00792 266835002438 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 266835002439 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 266835002440 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266835002441 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 266835002442 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266835002443 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266835002444 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266835002445 Uncharacterized conserved protein [Function unknown]; Region: COG3287 266835002446 FIST N domain; Region: FIST; cl10701 266835002447 FIST C domain; Region: FIST_C; pfam10442 266835002448 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835002449 dimer interface [polypeptide binding]; other site 266835002450 phosphorylation site [posttranslational modification] 266835002451 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835002452 ATP binding site [chemical binding]; other site 266835002453 Mg2+ binding site [ion binding]; other site 266835002454 G-X-G motif; other site 266835002455 Response regulator receiver domain; Region: Response_reg; pfam00072 266835002456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 266835002457 active site 266835002458 phosphorylation site [posttranslational modification] 266835002459 intermolecular recognition site; other site 266835002460 dimerization interface [polypeptide binding]; other site 266835002461 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266835002462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835002463 active site 266835002464 phosphorylation site [posttranslational modification] 266835002465 intermolecular recognition site; other site 266835002466 dimerization interface [polypeptide binding]; other site 266835002467 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835002468 DNA binding residues [nucleotide binding] 266835002469 dimerization interface [polypeptide binding]; other site 266835002470 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 266835002471 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 266835002472 maleylacetoacetate isomerase; Region: maiA; TIGR01262 266835002473 C-terminal domain interface [polypeptide binding]; other site 266835002474 GSH binding site (G-site) [chemical binding]; other site 266835002475 putative dimer interface [polypeptide binding]; other site 266835002476 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 266835002477 dimer interface [polypeptide binding]; other site 266835002478 N-terminal domain interface [polypeptide binding]; other site 266835002479 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 266835002480 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 266835002481 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 266835002482 putative NAD(P) binding site [chemical binding]; other site 266835002483 catalytic Zn binding site [ion binding]; other site 266835002484 structural Zn binding site [ion binding]; other site 266835002485 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 266835002486 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266835002487 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835002488 DNA-binding site [nucleotide binding]; DNA binding site 266835002489 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835002490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835002491 homodimer interface [polypeptide binding]; other site 266835002492 catalytic residue [active] 266835002493 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 266835002494 putative substrate binding pocket [chemical binding]; other site 266835002495 putative dimerization interface [polypeptide binding]; other site 266835002496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835002497 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 266835002498 putative active site [active] 266835002499 putative catalytic site [active] 266835002500 Phasin protein; Region: Phasin_2; cl11491 266835002501 Predicted membrane protein [Function unknown]; Region: COG2733 266835002502 Helix-turn-helix domains; Region: HTH; cl00088 266835002503 Rrf2 family protein; Region: rrf2_super; TIGR00738 266835002504 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 266835002505 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 266835002506 Walker A/P-loop; other site 266835002507 ATP binding site [chemical binding]; other site 266835002508 Q-loop/lid; other site 266835002509 ABC transporter signature motif; other site 266835002510 Walker B; other site 266835002511 D-loop; other site 266835002512 H-loop/switch region; other site 266835002513 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 266835002514 ABC-ATPase subunit interface; other site 266835002515 dimer interface [polypeptide binding]; other site 266835002516 putative PBP binding regions; other site 266835002517 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 266835002518 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 266835002519 putative hemin binding site; other site 266835002520 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 266835002521 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 266835002522 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 266835002523 Hemin uptake protein hemP; Region: hemP; cl10043 266835002524 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 266835002525 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266835002526 N-terminal plug; other site 266835002527 ligand-binding site [chemical binding]; other site 266835002528 Gram-negative bacterial tonB protein; Region: TonB; cl10048 266835002529 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 266835002530 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 266835002531 Proline dehydrogenase; Region: Pro_dh; cl03282 266835002532 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 266835002533 Glutamate binding site [chemical binding]; other site 266835002534 NAD binding site [chemical binding]; other site 266835002535 catalytic residues [active] 266835002536 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266835002537 NAD(P) binding site [chemical binding]; other site 266835002538 catalytic residues [active] 266835002539 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835002540 Helix-turn-helix domains; Region: HTH; cl00088 266835002541 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 266835002542 Cytochrome c; Region: Cytochrom_C; cl11414 266835002543 FixH; Region: FixH; cl01254 266835002544 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 266835002545 substrate binding site [chemical binding]; other site 266835002546 ATP binding site [chemical binding]; other site 266835002547 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 266835002548 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 266835002549 active site 266835002550 catalytic residues [active] 266835002551 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835002552 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266835002553 tetramerization interface [polypeptide binding]; other site 266835002554 NAD(P) binding site [chemical binding]; other site 266835002555 catalytic residues [active] 266835002556 Membrane transport protein; Region: Mem_trans; cl09117 266835002557 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 266835002558 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 266835002559 Tetratricopeptide repeat; Region: TPR_12; pfam13424 266835002560 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266835002561 catalytic core [active] 266835002562 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 266835002563 Phosphopantetheine attachment site; Region: PP-binding; cl09936 266835002564 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519 266835002565 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 266835002566 active site 266835002567 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501 266835002568 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 266835002569 dimer interface [polypeptide binding]; other site 266835002570 active site 266835002571 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266835002572 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266 266835002573 putative NAD(P) binding site [chemical binding]; other site 266835002574 structural Zn binding site [ion binding]; other site 266835002575 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 266835002576 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 266835002577 putative acyl-acceptor binding pocket; other site 266835002578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835002579 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266835002580 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835002581 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 266835002582 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 266835002583 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 266835002584 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 266835002585 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like6; cd08011 266835002586 metal binding site [ion binding]; metal-binding site 266835002587 putative dimer interface [polypeptide binding]; other site 266835002588 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835002589 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 266835002590 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835002591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835002592 dimer interface [polypeptide binding]; other site 266835002593 conserved gate region; other site 266835002594 putative PBP binding loops; other site 266835002595 ABC-ATPase subunit interface; other site 266835002596 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266835002597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835002598 dimer interface [polypeptide binding]; other site 266835002599 conserved gate region; other site 266835002600 putative PBP binding loops; other site 266835002601 ABC-ATPase subunit interface; other site 266835002602 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 266835002603 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835002604 Walker A/P-loop; other site 266835002605 ATP binding site [chemical binding]; other site 266835002606 Q-loop/lid; other site 266835002607 ABC transporter signature motif; other site 266835002608 Walker B; other site 266835002609 D-loop; other site 266835002610 H-loop/switch region; other site 266835002611 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835002612 Walker A/P-loop; other site 266835002613 ATP binding site [chemical binding]; other site 266835002614 Q-loop/lid; other site 266835002615 ABC transporter signature motif; other site 266835002616 Walker B; other site 266835002617 D-loop; other site 266835002618 H-loop/switch region; other site 266835002619 tellurium resistance terB-like protein; Region: terB_like; cd07177 266835002620 metal binding site [ion binding]; metal-binding site 266835002621 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 266835002622 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266835002623 Helix-turn-helix domain; Region: HTH_18; pfam12833 266835002624 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835002625 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 266835002626 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835002627 cobyric acid synthase; Provisional; Region: PRK00784 266835002628 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835002629 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835002630 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 266835002631 catalytic triad [active] 266835002632 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266835002633 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 266835002634 substrate binding pocket [chemical binding]; other site 266835002635 FAD binding site [chemical binding]; other site 266835002636 catalytic base [active] 266835002637 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835002638 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 266835002639 Cytochrome oxidase complex assembly protein 1; Region: Coa1; cl14904 266835002640 putative aminotransferase; Validated; Region: PRK07480 266835002641 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835002642 inhibitor-cofactor binding pocket; inhibition site 266835002643 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835002644 catalytic residue [active] 266835002645 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 266835002646 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835002647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835002648 putative substrate translocation pore; other site 266835002649 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 266835002650 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835002651 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835002652 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 266835002653 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 266835002654 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835002655 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266835002656 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266835002657 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266835002658 active site 266835002659 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 266835002660 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 266835002661 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 266835002662 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 266835002663 putative di-iron ligands [ion binding]; other site 266835002664 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835002665 non-specific DNA binding site [nucleotide binding]; other site 266835002666 salt bridge; other site 266835002667 sequence-specific DNA binding site [nucleotide binding]; other site 266835002668 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 266835002669 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 266835002670 von Willebrand factor; Region: vWF_A; pfam12450 266835002671 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 266835002672 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 266835002673 metal ion-dependent adhesion site (MIDAS); other site 266835002674 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 266835002675 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 266835002676 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835002677 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835002678 DNA binding residues [nucleotide binding] 266835002679 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 266835002680 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 266835002681 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 266835002682 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 266835002683 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 266835002684 B12 binding site [chemical binding]; other site 266835002685 cobalt ligand [ion binding]; other site 266835002686 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 266835002687 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835002688 extended (e) SDRs; Region: SDR_e; cd08946 266835002689 NAD(P) binding site [chemical binding]; other site 266835002690 active site 266835002691 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653 266835002692 putative active site [active] 266835002693 putative cosubstrate binding site; other site 266835002694 putative substrate binding site [chemical binding]; other site 266835002695 catalytic site [active] 266835002696 Virulence factor; Region: Virulence_fact; pfam13769 266835002697 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 266835002698 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 266835002699 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 266835002700 FAD binding site [chemical binding]; other site 266835002701 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 266835002702 Pterin binding enzyme; Region: Pterin_bind; pfam00809 266835002703 substrate binding pocket [chemical binding]; other site 266835002704 dimer interface [polypeptide binding]; other site 266835002705 inhibitor binding site; inhibition site 266835002706 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 266835002707 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 266835002708 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266835002709 catalytic loop [active] 266835002710 iron binding site [ion binding]; other site 266835002711 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835002712 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266835002713 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835002714 Helix-turn-helix domains; Region: HTH; cl00088 266835002715 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835002716 dimerization interface [polypeptide binding]; other site 266835002717 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266835002718 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 266835002719 conserved cys residue [active] 266835002720 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835002721 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835002722 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266835002723 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 266835002724 Walker A/P-loop; other site 266835002725 ATP binding site [chemical binding]; other site 266835002726 Q-loop/lid; other site 266835002727 ABC transporter signature motif; other site 266835002728 Walker B; other site 266835002729 D-loop; other site 266835002730 H-loop/switch region; other site 266835002731 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266835002732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835002733 dimer interface [polypeptide binding]; other site 266835002734 conserved gate region; other site 266835002735 putative PBP binding loops; other site 266835002736 ABC-ATPase subunit interface; other site 266835002737 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266835002738 NMT1-like family; Region: NMT1_2; cl15260 266835002739 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 266835002740 metal ion-dependent adhesion site (MIDAS); other site 266835002741 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835002742 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 266835002743 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 266835002744 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835002745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835002746 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 266835002747 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835002748 inhibitor-cofactor binding pocket; inhibition site 266835002749 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835002750 catalytic residue [active] 266835002751 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835002752 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835002753 NAD(P) binding site [chemical binding]; other site 266835002754 active site 266835002755 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 266835002756 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 266835002757 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266835002758 FAD binding domain; Region: FAD_binding_4; pfam01565 266835002759 hypothetical protein; Validated; Region: PRK08238 266835002760 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266835002761 UbiA prenyltransferase family; Region: UbiA; cl00337 266835002762 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835002763 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266835002764 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835002765 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 266835002766 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835002767 NAD(P) binding site [chemical binding]; other site 266835002768 active site 266835002769 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 266835002770 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 266835002771 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266835002772 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835002773 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835002774 Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767 266835002775 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 266835002776 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835002777 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 266835002778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835002779 putative transporter; Provisional; Region: PRK10504 266835002780 putative substrate translocation pore; other site 266835002781 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 266835002782 putative FMN binding site [chemical binding]; other site 266835002783 Helix-turn-helix domains; Region: HTH; cl00088 266835002784 Cupin domain; Region: Cupin_2; cl09118 266835002785 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835002786 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835002787 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 266835002788 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835002789 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 266835002790 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 266835002791 aspartate aminotransferase; Provisional; Region: PRK05764 266835002792 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835002793 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835002794 homodimer interface [polypeptide binding]; other site 266835002795 catalytic residue [active] 266835002796 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835002797 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835002798 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 266835002799 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 266835002800 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835002801 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835002802 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835002803 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835002804 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 266835002805 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 266835002806 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266835002807 FAD binding domain; Region: FAD_binding_4; pfam01565 266835002808 cytosine deaminase-like protein; Validated; Region: PRK07583 266835002809 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 266835002810 active site 266835002811 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266835002812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835002813 dimer interface [polypeptide binding]; other site 266835002814 conserved gate region; other site 266835002815 putative PBP binding loops; other site 266835002816 ABC-ATPase subunit interface; other site 266835002817 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266835002818 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 266835002819 Walker A/P-loop; other site 266835002820 ATP binding site [chemical binding]; other site 266835002821 Q-loop/lid; other site 266835002822 ABC transporter signature motif; other site 266835002823 Walker B; other site 266835002824 D-loop; other site 266835002825 H-loop/switch region; other site 266835002826 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266835002827 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266835002828 homotrimer interaction site [polypeptide binding]; other site 266835002829 putative active site [active] 266835002830 Creatinine amidohydrolase; Region: Creatininase; cl00618 266835002831 Uncharacterised protein family (UPF0156); Region: RHH_2; cl01448 266835002832 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 266835002833 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 266835002834 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 266835002835 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266835002836 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835002837 catalytic residue [active] 266835002838 CobD/Cbib protein; Region: CobD_Cbib; cl00561 266835002839 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835002840 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 266835002841 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 266835002842 homodimer interface [polypeptide binding]; other site 266835002843 Walker A motif; other site 266835002844 ATP binding site [chemical binding]; other site 266835002845 hydroxycobalamin binding site [chemical binding]; other site 266835002846 Walker B motif; other site 266835002847 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 266835002848 homotrimer interface [polypeptide binding]; other site 266835002849 Walker A motif; other site 266835002850 GTP binding site [chemical binding]; other site 266835002851 Walker B motif; other site 266835002852 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 266835002853 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 266835002854 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 266835002855 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 266835002856 [2Fe-2S] cluster binding site [ion binding]; other site 266835002857 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 266835002858 putative alpha subunit interface [polypeptide binding]; other site 266835002859 putative active site [active] 266835002860 putative substrate binding site [chemical binding]; other site 266835002861 Fe binding site [ion binding]; other site 266835002862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835002863 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835002864 putative substrate translocation pore; other site 266835002865 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 266835002866 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 266835002867 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 266835002868 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 266835002869 DNA binding residues [nucleotide binding] 266835002870 putative dimer interface [polypeptide binding]; other site 266835002871 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 266835002872 MgtE intracellular N domain; Region: MgtE_N; cl15244 266835002873 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 266835002874 Divalent cation transporter; Region: MgtE; cl00786 266835002875 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266835002876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835002877 active site 266835002878 phosphorylation site [posttranslational modification] 266835002879 intermolecular recognition site; other site 266835002880 dimerization interface [polypeptide binding]; other site 266835002881 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835002882 DNA binding residues [nucleotide binding] 266835002883 dimerization interface [polypeptide binding]; other site 266835002884 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 266835002885 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 266835002886 homodimer interface [polypeptide binding]; other site 266835002887 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835002888 catalytic residue [active] 266835002889 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 266835002890 malate--CoA ligase subunit beta; Provisional; Region: PRK14046 266835002891 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 266835002892 CoA-ligase; Region: Ligase_CoA; pfam00549 266835002893 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 266835002894 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835002895 CoA-ligase; Region: Ligase_CoA; pfam00549 266835002896 Domain of unknown function DUF302; Region: DUF302; cl01364 266835002897 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835002898 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835002899 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835002900 Cupin domain; Region: Cupin_2; cl09118 266835002901 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266835002902 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835002903 MltA-interacting protein MipA; Region: MipA; cl01504 266835002904 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835002905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835002906 active site 266835002907 phosphorylation site [posttranslational modification] 266835002908 intermolecular recognition site; other site 266835002909 dimerization interface [polypeptide binding]; other site 266835002910 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835002911 DNA binding site [nucleotide binding] 266835002912 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266835002913 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266835002914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835002915 ATP binding site [chemical binding]; other site 266835002916 Mg2+ binding site [ion binding]; other site 266835002917 G-X-G motif; other site 266835002918 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 266835002919 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 266835002920 hydrophobic ligand binding site; other site 266835002921 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 266835002922 active site 266835002923 putative substrate binding region [chemical binding]; other site 266835002924 GYD domain; Region: GYD; cl01743 266835002925 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 266835002926 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 266835002927 Walker A/P-loop; other site 266835002928 ATP binding site [chemical binding]; other site 266835002929 Q-loop/lid; other site 266835002930 ABC transporter signature motif; other site 266835002931 Walker B; other site 266835002932 D-loop; other site 266835002933 H-loop/switch region; other site 266835002934 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 266835002935 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 266835002936 FtsX-like permease family; Region: FtsX; pfam02687 266835002937 prolyl-tRNA synthetase; Provisional; Region: PRK12325 266835002938 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 266835002939 dimer interface [polypeptide binding]; other site 266835002940 motif 1; other site 266835002941 active site 266835002942 motif 2; other site 266835002943 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 266835002944 active site 266835002945 motif 3; other site 266835002946 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 266835002947 anticodon binding site; other site 266835002948 Protein of unknown function (DUF1467); Region: DUF1467; cl11569 266835002949 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835002950 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 266835002951 dimer interface [polypeptide binding]; other site 266835002952 substrate binding site [chemical binding]; other site 266835002953 metal binding site [ion binding]; metal-binding site 266835002954 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266835002955 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 266835002956 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266835002957 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 266835002958 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 266835002959 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 266835002960 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 266835002961 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 266835002962 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 266835002963 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 266835002964 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 266835002965 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 266835002966 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 266835002967 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 266835002968 NADH dehydrogenase subunit 6; Validated; Region: ND6; MTH00021 266835002969 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 266835002970 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 266835002971 4Fe-4S binding domain; Region: Fer4; cl02805 266835002972 4Fe-4S binding domain; Region: Fer4; cl02805 266835002973 NADH dehydrogenase; Region: NADHdh; cl00469 266835002974 NADH dehydrogenase subunit G; Validated; Region: PRK09130 266835002975 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266835002976 catalytic loop [active] 266835002977 iron binding site [ion binding]; other site 266835002978 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 266835002979 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 266835002980 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 266835002981 Uncharacterized conserved protein [Function unknown]; Region: COG3743 266835002982 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 266835002983 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 266835002984 SLBB domain; Region: SLBB; pfam10531 266835002985 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 266835002986 NADH dehydrogenase subunit E; Provisional; Region: PRK12373 266835002987 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 266835002988 putative dimer interface [polypeptide binding]; other site 266835002989 [2Fe-2S] cluster binding site [ion binding]; other site 266835002990 Uncharacterized conserved protein [Function unknown]; Region: COG3743 266835002991 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 266835002992 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 266835002993 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 266835002994 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 266835002995 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 266835002996 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 266835002997 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 266835002998 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 266835002999 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835003000 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 266835003001 cobaltochelatase, CobN subunit; Region: cobalto_cobN; TIGR02257 266835003002 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 266835003003 precorrin-3B synthase; Region: CobG; TIGR02435 266835003004 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 266835003005 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 266835003006 Precorrin-8X methylmutase; Region: CbiC; pfam02570 266835003007 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 266835003008 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 266835003009 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 266835003010 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 266835003011 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 266835003012 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 266835003013 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 266835003014 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 266835003015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 266835003016 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 266835003017 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 266835003018 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 266835003019 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 266835003020 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835003021 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 266835003022 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 266835003023 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 266835003024 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 266835003025 putative dimer interface [polypeptide binding]; other site 266835003026 active site pocket [active] 266835003027 putative cataytic base [active] 266835003028 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 266835003029 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 266835003030 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 266835003031 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266835003032 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266835003033 lipoyl-biotinyl attachment site [posttranslational modification]; other site 266835003034 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 266835003035 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 266835003036 Walker A/P-loop; other site 266835003037 ATP binding site [chemical binding]; other site 266835003038 Q-loop/lid; other site 266835003039 ABC transporter signature motif; other site 266835003040 Walker B; other site 266835003041 D-loop; other site 266835003042 H-loop/switch region; other site 266835003043 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 266835003044 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 266835003045 FtsX-like permease family; Region: FtsX; pfam02687 266835003046 BA14K-like protein; Region: BA14K; pfam07886 266835003047 ketol-acid reductoisomerase; Provisional; Region: PRK05479 266835003048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835003049 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 266835003050 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835003051 Helix-turn-helix domains; Region: HTH; cl00088 266835003052 Helix-turn-helix domains; Region: HTH; cl00088 266835003053 Helix-turn-helix domains; Region: HTH; cl00088 266835003054 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 266835003055 iron-sulfur cluster [ion binding]; other site 266835003056 [2Fe-2S] cluster binding site [ion binding]; other site 266835003057 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835003058 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 266835003059 C-terminal domain interface [polypeptide binding]; other site 266835003060 GSH binding site (G-site) [chemical binding]; other site 266835003061 dimer interface [polypeptide binding]; other site 266835003062 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 266835003063 N-terminal domain interface [polypeptide binding]; other site 266835003064 dimer interface [polypeptide binding]; other site 266835003065 substrate binding pocket (H-site) [chemical binding]; other site 266835003066 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 266835003067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835003068 Helix-turn-helix domains; Region: HTH; cl00088 266835003069 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 266835003070 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 266835003071 NADP binding site [chemical binding]; other site 266835003072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835003073 K+ potassium transporter; Region: K_trans; cl15781 266835003074 Amino acid permease; Region: AA_permease; cl00524 266835003075 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 266835003076 active site 266835003077 hydrophilic channel; other site 266835003078 dimerization interface [polypeptide binding]; other site 266835003079 catalytic residues [active] 266835003080 active site lid [active] 266835003081 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835003082 Family description; Region: UvrD_C_2; cl15862 266835003083 nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486 266835003084 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 266835003085 nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486 266835003086 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 266835003087 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 266835003088 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 266835003089 Protein export membrane protein; Region: SecD_SecF; cl14618 266835003090 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266835003091 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266835003092 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266835003093 LysE type translocator; Region: LysE; cl00565 266835003094 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 266835003095 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 266835003096 putative valine binding site [chemical binding]; other site 266835003097 dimer interface [polypeptide binding]; other site 266835003098 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 266835003099 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 266835003100 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266835003101 PYR/PP interface [polypeptide binding]; other site 266835003102 dimer interface [polypeptide binding]; other site 266835003103 TPP binding site [chemical binding]; other site 266835003104 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 266835003105 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 266835003106 TPP-binding site [chemical binding]; other site 266835003107 dimer interface [polypeptide binding]; other site 266835003108 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266835003109 PcfJ-like protein; Region: PcfJ; pfam14284 266835003110 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 266835003111 gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409 266835003112 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 266835003113 substrate binding pocket [chemical binding]; other site 266835003114 active site 266835003115 iron coordination sites [ion binding]; other site 266835003116 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266835003117 Helix-turn-helix domains; Region: HTH; cl00088 266835003118 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835003119 dimerization interface [polypeptide binding]; other site 266835003120 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835003121 non-specific DNA binding site [nucleotide binding]; other site 266835003122 salt bridge; other site 266835003123 sequence-specific DNA binding site [nucleotide binding]; other site 266835003124 HerA helicase [Replication, recombination, and repair]; Region: COG0433 266835003125 Domain of unknown function DUF87; Region: DUF87; pfam01935 266835003126 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835003127 metal binding site [ion binding]; metal-binding site 266835003128 active site 266835003129 I-site; other site 266835003130 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 266835003131 IPP transferase; Region: IPPT; cl00403 266835003132 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 266835003133 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266835003134 motif II; other site 266835003135 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 266835003136 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835003137 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 266835003138 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 266835003139 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266835003140 protein binding site [polypeptide binding]; other site 266835003141 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266835003142 protein binding site [polypeptide binding]; other site 266835003143 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; cl01275 266835003144 FtsH protease regulator HflC; Provisional; Region: PRK11029 266835003145 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 266835003146 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 266835003147 HflK protein; Region: hflK; TIGR01933 266835003148 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 266835003149 folate binding site [chemical binding]; other site 266835003150 NADP+ binding site [chemical binding]; other site 266835003151 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 266835003152 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 266835003153 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 266835003154 Helix-turn-helix domains; Region: HTH; cl00088 266835003155 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 266835003156 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835003157 Walker A/P-loop; other site 266835003158 ATP binding site [chemical binding]; other site 266835003159 Q-loop/lid; other site 266835003160 ABC transporter signature motif; other site 266835003161 Walker B; other site 266835003162 D-loop; other site 266835003163 H-loop/switch region; other site 266835003164 TOBE domain; Region: TOBE_2; cl01440 266835003165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835003166 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835003167 TOBE domain; Region: TOBE_2; cl01440 266835003168 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 266835003169 dimerization interface [polypeptide binding]; other site 266835003170 active site 266835003171 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 266835003172 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835003173 AAA domain; Region: AAA_28; pfam13521 266835003174 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 266835003175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835003176 putative substrate translocation pore; other site 266835003177 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835003178 Helix-turn-helix domains; Region: HTH; cl00088 266835003179 Stringent starvation protein B; Region: SspB; cl01120 266835003180 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 266835003181 Ribbon-helix-helix domain; Region: RHH_4; cl01775 266835003182 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 266835003183 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 266835003184 Cl- selectivity filter; other site 266835003185 Cl- binding residues [ion binding]; other site 266835003186 pore gating glutamate residue; other site 266835003187 dimer interface [polypeptide binding]; other site 266835003188 FOG: CBS domain [General function prediction only]; Region: COG0517 266835003189 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 266835003190 Helix-turn-helix domains; Region: HTH; cl00088 266835003191 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 266835003192 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835003193 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 266835003194 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266835003195 AsmA family; Region: AsmA; pfam05170 266835003196 AsmA-like C-terminal region; Region: AsmA_2; cl15864 266835003197 AsmA-like C-terminal region; Region: AsmA_2; cl15864 266835003198 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 266835003199 D-lactate dehydrogenase [cytochrome]; Region: PLN02805 266835003200 FAD binding domain; Region: FAD_binding_4; pfam01565 266835003201 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266835003202 active site 266835003203 Helix-turn-helix domains; Region: HTH; cl00088 266835003204 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 266835003205 EamA-like transporter family; Region: EamA; cl01037 266835003206 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 266835003207 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 266835003208 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 266835003209 Trp docking motif [polypeptide binding]; other site 266835003210 putative active site [active] 266835003211 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 266835003212 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 266835003213 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835003214 RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; Region: RhoGAP; cl02570 266835003215 catalytic residue [active] 266835003216 Family description; Region: UvrD_C_2; cl15862 266835003217 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 266835003218 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835003219 TM-ABC transporter signature motif; other site 266835003220 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266835003221 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835003222 Walker A/P-loop; other site 266835003223 ATP binding site [chemical binding]; other site 266835003224 Q-loop/lid; other site 266835003225 ABC transporter signature motif; other site 266835003226 Walker B; other site 266835003227 D-loop; other site 266835003228 H-loop/switch region; other site 266835003229 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 266835003230 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266835003231 putative ligand binding site [chemical binding]; other site 266835003232 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266835003233 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835003234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835003235 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 266835003236 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266835003237 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835003238 DNA binding site [nucleotide binding] 266835003239 domain linker motif; other site 266835003240 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 266835003241 ligand binding site [chemical binding]; other site 266835003242 Uncharacterized conserved protein [Function unknown]; Region: COG3461 266835003243 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 266835003244 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 266835003245 FAD dependent oxidoreductase; Region: DAO; pfam01266 266835003246 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 266835003247 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 266835003248 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835003249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 266835003250 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 266835003251 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 266835003252 MatE; Region: MatE; cl10513 266835003253 MatE; Region: MatE; cl10513 266835003254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835003255 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 266835003256 hypothetical protein; Provisional; Region: PRK06194 266835003257 classical (c) SDRs; Region: SDR_c; cd05233 266835003258 NAD(P) binding site [chemical binding]; other site 266835003259 active site 266835003260 Low affinity iron permease; Region: Iron_permease; cl12096 266835003261 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 266835003262 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 266835003263 trimer interface [polypeptide binding]; other site 266835003264 active site 266835003265 substrate binding site [chemical binding]; other site 266835003266 CoA binding site [chemical binding]; other site 266835003267 CreA protein; Region: CreA; pfam05981 266835003268 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 266835003269 Cu(I) binding site [ion binding]; other site 266835003270 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 266835003271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835003272 S-adenosylmethionine binding site [chemical binding]; other site 266835003273 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 266835003274 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 266835003275 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 266835003276 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 266835003277 Autotransporter beta-domain; Region: Autotransporter; cl02365 266835003278 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266835003279 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266835003280 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 266835003281 active site 266835003282 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 266835003283 AzlC protein; Region: AzlC; cl00570 266835003284 Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374 266835003285 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 266835003286 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 266835003287 nucleotide binding pocket [chemical binding]; other site 266835003288 K-X-D-G motif; other site 266835003289 catalytic site [active] 266835003290 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 266835003291 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 266835003292 Dimer interface [polypeptide binding]; other site 266835003293 BRCT sequence motif; other site 266835003294 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 266835003295 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 266835003296 Walker A/P-loop; other site 266835003297 ATP binding site [chemical binding]; other site 266835003298 Q-loop/lid; other site 266835003299 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 266835003300 Q-loop/lid; other site 266835003301 ABC transporter signature motif; other site 266835003302 Walker B; other site 266835003303 D-loop; other site 266835003304 H-loop/switch region; other site 266835003305 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 266835003306 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 266835003307 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 266835003308 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 266835003309 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 266835003310 nucleotide binding site [chemical binding]; other site 266835003311 SulA interaction site; other site 266835003312 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 266835003313 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 266835003314 Cell division protein FtsA; Region: FtsA; cl11496 266835003315 Cell division protein FtsA; Region: FtsA; cl11496 266835003316 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 266835003317 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 266835003318 Cell division protein FtsQ; Region: FtsQ; pfam03799 266835003319 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 266835003320 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 266835003321 ATP-grasp domain; Region: ATP-grasp_4; cl03087 266835003322 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 266835003323 FAD binding domain; Region: FAD_binding_4; pfam01565 266835003324 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 266835003325 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 266835003326 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 266835003327 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 266835003328 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266835003329 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 266835003330 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 266835003331 active site 266835003332 homodimer interface [polypeptide binding]; other site 266835003333 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 266835003334 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 266835003335 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 266835003336 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266835003337 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 266835003338 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 266835003339 Mg++ binding site [ion binding]; other site 266835003340 putative catalytic motif [active] 266835003341 putative substrate binding site [chemical binding]; other site 266835003342 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 266835003343 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 266835003344 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266835003345 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 266835003346 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 266835003347 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 266835003348 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266835003349 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 266835003350 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 266835003351 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 266835003352 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 266835003353 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 266835003354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835003355 cystathionine gamma-lyase; Validated; Region: PRK07582 266835003356 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 266835003357 homodimer interface [polypeptide binding]; other site 266835003358 substrate-cofactor binding pocket; other site 266835003359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835003360 catalytic residue [active] 266835003361 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 266835003362 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266835003363 catalytic residue [active] 266835003364 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 266835003365 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 266835003366 amidase catalytic site [active] 266835003367 Zn binding residues [ion binding]; other site 266835003368 substrate binding site [chemical binding]; other site 266835003369 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 266835003370 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 266835003371 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 266835003372 putative metal binding site [ion binding]; other site 266835003373 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266835003374 HSP70 interaction site [polypeptide binding]; other site 266835003375 5-oxoprolinase; Region: PLN02666 266835003376 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266835003377 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 266835003378 Protein of unknown function (DUF3419); Region: DUF3419; cl15422 266835003379 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835003380 S-adenosylmethionine binding site [chemical binding]; other site 266835003381 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 266835003382 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835003383 non-specific DNA binding site [nucleotide binding]; other site 266835003384 salt bridge; other site 266835003385 sequence-specific DNA binding site [nucleotide binding]; other site 266835003386 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 266835003387 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 266835003388 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 266835003389 active site 266835003390 Transglycosylase SLT domain; Region: SLT_2; pfam13406 266835003391 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 266835003392 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 266835003393 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835003394 Helix-turn-helix domains; Region: HTH; cl00088 266835003395 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 266835003396 putative effector binding pocket; other site 266835003397 putative dimerization interface [polypeptide binding]; other site 266835003398 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266835003399 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835003400 NAD(P) binding site [chemical binding]; other site 266835003401 active site 266835003402 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 266835003403 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 266835003404 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266835003405 catalytic residue [active] 266835003406 EamA-like transporter family; Region: EamA; cl01037 266835003407 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 266835003408 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 266835003409 FAD binding site [chemical binding]; other site 266835003410 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835003411 putative Zn2+ binding site [ion binding]; other site 266835003412 putative DNA binding site [nucleotide binding]; other site 266835003413 Methyltransferase domain; Region: Methyltransf_31; pfam13847 266835003414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835003415 S-adenosylmethionine binding site [chemical binding]; other site 266835003416 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 266835003417 homodimer interaction site [polypeptide binding]; other site 266835003418 cofactor binding site; other site 266835003419 Uncharacterized conserved protein (DUF2293); Region: DUF2293; cl02373 266835003420 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 266835003421 homodimer interface [polypeptide binding]; other site 266835003422 substrate-cofactor binding pocket; other site 266835003423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835003424 catalytic residue [active] 266835003425 short chain dehydrogenase; Provisional; Region: PRK08263 266835003426 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266835003427 NADP binding site [chemical binding]; other site 266835003428 active site 266835003429 steroid binding site; other site 266835003430 MOSC domain; Region: MOSC; pfam03473 266835003431 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835003432 Helix-turn-helix domains; Region: HTH; cl00088 266835003433 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 266835003434 dimer interface [polypeptide binding]; other site 266835003435 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835003436 Phospholipid methyltransferase; Region: PEMT; cl00763 266835003437 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 266835003438 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 266835003439 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 266835003440 dimer interface [polypeptide binding]; other site 266835003441 active site 266835003442 CoA binding pocket [chemical binding]; other site 266835003443 trans-aconitate 2-methyltransferase; Provisional; Region: PRK01683 266835003444 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835003445 S-adenosylmethionine binding site [chemical binding]; other site 266835003446 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 266835003447 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835003448 Walker A/P-loop; other site 266835003449 ATP binding site [chemical binding]; other site 266835003450 Q-loop/lid; other site 266835003451 ABC transporter signature motif; other site 266835003452 Walker B; other site 266835003453 D-loop; other site 266835003454 H-loop/switch region; other site 266835003455 ABC transporter; Region: ABC_tran_2; pfam12848 266835003456 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 266835003457 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835003458 metal binding site [ion binding]; metal-binding site 266835003459 active site 266835003460 I-site; other site 266835003461 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 266835003462 B1 nucleotide binding pocket [chemical binding]; other site 266835003463 B2 nucleotide binding pocket [chemical binding]; other site 266835003464 CAS motifs; other site 266835003465 active site 266835003466 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 266835003467 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835003468 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266835003469 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266835003470 thiamine pyrophosphate protein; Validated; Region: PRK08199 266835003471 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266835003472 PYR/PP interface [polypeptide binding]; other site 266835003473 dimer interface [polypeptide binding]; other site 266835003474 TPP binding site [chemical binding]; other site 266835003475 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 266835003476 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 266835003477 TPP-binding site [chemical binding]; other site 266835003478 CHRD domain; Region: CHRD; cl06473 266835003479 methionine gamma-lyase; Validated; Region: PRK07049 266835003480 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 266835003481 homodimer interface [polypeptide binding]; other site 266835003482 substrate-cofactor binding pocket; other site 266835003483 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835003484 catalytic residue [active] 266835003485 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835003486 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835003487 putative DNA binding site [nucleotide binding]; other site 266835003488 putative Zn2+ binding site [ion binding]; other site 266835003489 Helix-turn-helix domains; Region: HTH; cl00088 266835003490 NMT1/THI5 like; Region: NMT1; pfam09084 266835003491 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 266835003492 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266835003493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835003494 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266835003495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835003496 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266835003497 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 266835003498 Walker A/P-loop; other site 266835003499 ATP binding site [chemical binding]; other site 266835003500 Q-loop/lid; other site 266835003501 ABC transporter signature motif; other site 266835003502 Walker B; other site 266835003503 D-loop; other site 266835003504 H-loop/switch region; other site 266835003505 Cupin domain; Region: Cupin_2; cl09118 266835003506 phenylhydantoinase; Validated; Region: PRK08323 266835003507 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 266835003508 tetramer interface [polypeptide binding]; other site 266835003509 active site 266835003510 allantoate amidohydrolase; Reviewed; Region: PRK12893 266835003511 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 266835003512 active site 266835003513 metal binding site [ion binding]; metal-binding site 266835003514 dimer interface [polypeptide binding]; other site 266835003515 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 266835003516 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835003517 inhibitor-cofactor binding pocket; inhibition site 266835003518 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835003519 catalytic residue [active] 266835003520 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 266835003521 Helix-turn-helix domains; Region: HTH; cl00088 266835003522 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 266835003523 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 266835003524 short chain dehydrogenase; Provisional; Region: PRK12828 266835003525 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 266835003526 putative NAD(P) binding site [chemical binding]; other site 266835003527 active site 266835003528 short chain dehydrogenase; Provisional; Region: PRK07041 266835003529 classical (c) SDRs; Region: SDR_c; cd05233 266835003530 NAD(P) binding site [chemical binding]; other site 266835003531 active site 266835003532 DoxX; Region: DoxX; cl00976 266835003533 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266835003534 Predicted transcriptional regulator [Transcription]; Region: COG1959 266835003535 Helix-turn-helix domains; Region: HTH; cl00088 266835003536 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 266835003537 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 266835003538 homodimer interface [polypeptide binding]; other site 266835003539 active site 266835003540 FMN binding site [chemical binding]; other site 266835003541 substrate binding site [chemical binding]; other site 266835003542 4Fe-4S binding domain; Region: Fer4; cl02805 266835003543 4Fe-4S binding domain; Region: Fer4; cl02805 266835003544 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 266835003545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835003546 S-adenosylmethionine binding site [chemical binding]; other site 266835003547 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 266835003548 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 266835003549 putative active site pocket [active] 266835003550 dimerization interface [polypeptide binding]; other site 266835003551 putative catalytic residue [active] 266835003552 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 266835003553 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835003554 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835003555 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 266835003556 DoxX; Region: DoxX; cl00976 266835003557 FAD dependent oxidoreductase; Region: DAO; pfam01266 266835003558 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 266835003559 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 266835003560 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835003561 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 266835003562 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 266835003563 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266835003564 catalytic residue [active] 266835003565 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 266835003566 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835003567 Walker A/P-loop; other site 266835003568 ATP binding site [chemical binding]; other site 266835003569 Q-loop/lid; other site 266835003570 ABC transporter signature motif; other site 266835003571 Walker B; other site 266835003572 D-loop; other site 266835003573 H-loop/switch region; other site 266835003574 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835003575 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835003576 Walker A/P-loop; other site 266835003577 ATP binding site [chemical binding]; other site 266835003578 Q-loop/lid; other site 266835003579 ABC transporter signature motif; other site 266835003580 Walker B; other site 266835003581 D-loop; other site 266835003582 H-loop/switch region; other site 266835003583 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835003584 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266835003585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835003586 dimer interface [polypeptide binding]; other site 266835003587 conserved gate region; other site 266835003588 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835003589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835003590 dimer interface [polypeptide binding]; other site 266835003591 conserved gate region; other site 266835003592 putative PBP binding loops; other site 266835003593 ABC-ATPase subunit interface; other site 266835003594 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835003595 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 266835003596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 266835003597 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 266835003598 Family of unknown function (DUF490); Region: DUF490; pfam04357 266835003599 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 266835003600 Surface antigen; Region: Bac_surface_Ag; cl03097 266835003601 Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100 266835003602 putative binding site; other site 266835003603 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 266835003604 MG2 domain; Region: A2M_N; pfam01835 266835003605 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 266835003606 Alpha-2-macroglobulin family; Region: A2M; pfam00207 266835003607 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 266835003608 surface patch; other site 266835003609 thioester region; other site 266835003610 specificity defining residues; other site 266835003611 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 266835003612 Transglycosylase; Region: Transgly; cl07896 266835003613 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 266835003614 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 266835003615 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 266835003616 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835003617 sulfate ABC transporter, permease protein CysT; Region: permease_CysT; TIGR02139 266835003618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835003619 dimer interface [polypeptide binding]; other site 266835003620 conserved gate region; other site 266835003621 putative PBP binding loops; other site 266835003622 ABC-ATPase subunit interface; other site 266835003623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835003624 dimer interface [polypeptide binding]; other site 266835003625 conserved gate region; other site 266835003626 putative PBP binding loops; other site 266835003627 ABC-ATPase subunit interface; other site 266835003628 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 266835003629 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296 266835003630 Walker A/P-loop; other site 266835003631 ATP binding site [chemical binding]; other site 266835003632 Q-loop/lid; other site 266835003633 ABC transporter signature motif; other site 266835003634 Walker B; other site 266835003635 D-loop; other site 266835003636 H-loop/switch region; other site 266835003637 TOBE-like domain; Region: TOBE_3; pfam12857 266835003638 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 266835003639 oligomeric interface; other site 266835003640 putative active site [active] 266835003641 homodimer interface [polypeptide binding]; other site 266835003642 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 266835003643 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835003644 Predicted transcriptional regulator [Transcription]; Region: COG1959 266835003645 Helix-turn-helix domains; Region: HTH; cl00088 266835003646 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 266835003647 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 266835003648 ATP-binding site [chemical binding]; other site 266835003649 Gluconate-6-phosphate binding site [chemical binding]; other site 266835003650 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835003651 TM-ABC transporter signature motif; other site 266835003652 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835003653 TM-ABC transporter signature motif; other site 266835003654 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835003655 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 266835003656 Walker A/P-loop; other site 266835003657 ATP binding site [chemical binding]; other site 266835003658 Q-loop/lid; other site 266835003659 ABC transporter signature motif; other site 266835003660 Walker B; other site 266835003661 D-loop; other site 266835003662 H-loop/switch region; other site 266835003663 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 266835003664 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 266835003665 putative ligand binding site [chemical binding]; other site 266835003666 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266835003667 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835003668 DNA binding site [nucleotide binding] 266835003669 domain linker motif; other site 266835003670 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 266835003671 putative ligand binding site [chemical binding]; other site 266835003672 putative dimerization interface [polypeptide binding]; other site 266835003673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835003674 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835003675 putative substrate translocation pore; other site 266835003676 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266835003677 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835003678 DNA-binding site [nucleotide binding]; DNA binding site 266835003679 FCD domain; Region: FCD; cl11656 266835003680 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835003681 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835003682 NAD(P) binding site [chemical binding]; other site 266835003683 active site 266835003684 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266835003685 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835003686 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266835003687 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835003688 DNA-binding site [nucleotide binding]; DNA binding site 266835003689 FCD domain; Region: FCD; cl11656 266835003690 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 266835003691 ligand binding site [chemical binding]; other site 266835003692 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266835003693 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835003694 Walker A/P-loop; other site 266835003695 ATP binding site [chemical binding]; other site 266835003696 Q-loop/lid; other site 266835003697 ABC transporter signature motif; other site 266835003698 Walker B; other site 266835003699 D-loop; other site 266835003700 H-loop/switch region; other site 266835003701 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835003702 TM-ABC transporter signature motif; other site 266835003703 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266835003704 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835003705 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 266835003706 putative hydrophobic ligand binding site [chemical binding]; other site 266835003707 protein interface [polypeptide binding]; other site 266835003708 gate; other site 266835003709 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 266835003710 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 266835003711 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266835003712 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266835003713 catalytic loop [active] 266835003714 iron binding site [ion binding]; other site 266835003715 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266835003716 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 266835003717 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266835003718 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266835003719 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835003720 Walker A motif; other site 266835003721 ATP binding site [chemical binding]; other site 266835003722 Walker B motif; other site 266835003723 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 266835003724 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 266835003725 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266835003726 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835003727 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835003728 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835003729 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835003730 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835003731 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835003732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835003733 dimer interface [polypeptide binding]; other site 266835003734 conserved gate region; other site 266835003735 putative PBP binding loops; other site 266835003736 ABC-ATPase subunit interface; other site 266835003737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835003738 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266835003739 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835003740 Walker A/P-loop; other site 266835003741 ATP binding site [chemical binding]; other site 266835003742 Q-loop/lid; other site 266835003743 ABC transporter signature motif; other site 266835003744 Walker B; other site 266835003745 D-loop; other site 266835003746 H-loop/switch region; other site 266835003747 TOBE domain; Region: TOBE_2; cl01440 266835003748 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 266835003749 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266835003750 active site 266835003751 metal binding site [ion binding]; metal-binding site 266835003752 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266835003753 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835003754 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 266835003755 Walker A/P-loop; other site 266835003756 ATP binding site [chemical binding]; other site 266835003757 Q-loop/lid; other site 266835003758 ABC transporter signature motif; other site 266835003759 Walker B; other site 266835003760 D-loop; other site 266835003761 H-loop/switch region; other site 266835003762 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 266835003763 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 266835003764 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835003765 TM-ABC transporter signature motif; other site 266835003766 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 266835003767 Strictosidine synthase; Region: Str_synth; pfam03088 266835003768 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 266835003769 ligand binding site [chemical binding]; other site 266835003770 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835003771 TM-ABC transporter signature motif; other site 266835003772 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835003773 putative transporter; Provisional; Region: PRK10504 266835003774 putative substrate translocation pore; other site 266835003775 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 266835003776 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835003777 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 266835003778 active sites [active] 266835003779 tetramer interface [polypeptide binding]; other site 266835003780 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 266835003781 oligomerization interface [polypeptide binding]; other site 266835003782 active site 266835003783 metal binding site [ion binding]; metal-binding site 266835003784 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 266835003785 [2Fe-2S] cluster binding site [ion binding]; other site 266835003786 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 266835003787 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 266835003788 putative di-iron ligands [ion binding]; other site 266835003789 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266835003790 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 266835003791 AP (apurinic/apyrimidinic) site pocket; other site 266835003792 DNA interaction; other site 266835003793 Metal-binding active site; metal-binding site 266835003794 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835003795 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835003796 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 266835003797 Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356 266835003798 substrate binding site [chemical binding]; other site 266835003799 Protein of unknown function (DUF521); Region: DUF521; pfam04412 266835003800 Putative Aconitase X catalytic domain; Region: AcnX; cd01355 266835003801 substrate binding site [chemical binding]; other site 266835003802 ligand binding site [chemical binding]; other site 266835003803 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835003804 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835003805 Walker A/P-loop; other site 266835003806 ATP binding site [chemical binding]; other site 266835003807 Q-loop/lid; other site 266835003808 ABC transporter signature motif; other site 266835003809 Walker B; other site 266835003810 D-loop; other site 266835003811 H-loop/switch region; other site 266835003812 TOBE domain; Region: TOBE_2; cl01440 266835003813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835003814 dimer interface [polypeptide binding]; other site 266835003815 conserved gate region; other site 266835003816 putative PBP binding loops; other site 266835003817 ABC-ATPase subunit interface; other site 266835003818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835003819 dimer interface [polypeptide binding]; other site 266835003820 conserved gate region; other site 266835003821 putative PBP binding loops; other site 266835003822 ABC-ATPase subunit interface; other site 266835003823 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835003824 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835003825 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266835003826 YegV-like sugar kinase. Found only in bacteria, YegV-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YegV_kinase_like; cd01944 266835003827 substrate binding site [chemical binding]; other site 266835003828 ATP binding site [chemical binding]; other site 266835003829 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 266835003830 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 266835003831 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835003832 DNA-binding site [nucleotide binding]; DNA binding site 266835003833 UTRA domain; Region: UTRA; cl01230 266835003834 PAS fold; Region: PAS; pfam00989 266835003835 Histidine kinase; Region: HisKA_2; cl06527 266835003836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835003837 ATP binding site [chemical binding]; other site 266835003838 Mg2+ binding site [ion binding]; other site 266835003839 G-X-G motif; other site 266835003840 Phospholipid methyltransferase; Region: PEMT; cl00763 266835003841 NMT1/THI5 like; Region: NMT1; pfam09084 266835003842 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 266835003843 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 266835003844 Walker A/P-loop; other site 266835003845 ATP binding site [chemical binding]; other site 266835003846 Q-loop/lid; other site 266835003847 ABC transporter signature motif; other site 266835003848 Walker B; other site 266835003849 D-loop; other site 266835003850 H-loop/switch region; other site 266835003851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835003852 Domain of unknown function DUF77; Region: DUF77; cl00307 266835003853 Domain of unknown function DUF77; Region: DUF77; cl00307 266835003854 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 266835003855 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 266835003856 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835003857 Coenzyme A binding pocket [chemical binding]; other site 266835003858 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565 266835003859 Terminase-like family; Region: Terminase_6; pfam03237 266835003860 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565 266835003861 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 266835003862 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835003863 active site 266835003864 metal binding site [ion binding]; metal-binding site 266835003865 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 266835003866 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 266835003867 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835003868 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 266835003869 active site 266835003870 Domain of unknown function (DUF378); Region: DUF378; cl00943 266835003871 PAS domain S-box; Region: sensory_box; TIGR00229 266835003872 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835003873 putative active site [active] 266835003874 heme pocket [chemical binding]; other site 266835003875 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266835003876 Histidine kinase; Region: HisKA_2; cl06527 266835003877 nickel responsive regulator; Provisional; Region: PRK02967 266835003878 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 266835003879 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835003880 active site 266835003881 catalytic tetrad [active] 266835003882 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 266835003883 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 266835003884 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266835003885 Sel1 repeat; Region: Sel1; cl02723 266835003886 Sel1 repeat; Region: Sel1; cl02723 266835003887 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266835003888 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 266835003889 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such...; Region: APH_ChoK_like_1; cd05155 266835003890 putative active site [active] 266835003891 putative substrate binding site [chemical binding]; other site 266835003892 ATP binding site [chemical binding]; other site 266835003893 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 266835003894 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 266835003895 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 266835003896 ATP-grasp domain; Region: ATP-grasp_4; cl03087 266835003897 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 266835003898 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 266835003899 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835003900 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 266835003901 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835003902 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835003903 homodimer interface [polypeptide binding]; other site 266835003904 catalytic residue [active] 266835003905 putative acetyltransferase; Provisional; Region: PRK03624 266835003906 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835003907 Coenzyme A binding pocket [chemical binding]; other site 266835003908 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 266835003909 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266835003910 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835003911 DNA-binding site [nucleotide binding]; DNA binding site 266835003912 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835003913 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835003914 homodimer interface [polypeptide binding]; other site 266835003915 catalytic residue [active] 266835003916 Bacterial protein of unknown function (DUF922); Region: DUF922; cl02415 266835003917 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835003918 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835003919 putative DNA binding site [nucleotide binding]; other site 266835003920 dimerization interface [polypeptide binding]; other site 266835003921 putative Zn2+ binding site [ion binding]; other site 266835003922 Helix-turn-helix domains; Region: HTH; cl00088 266835003923 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 266835003924 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835003925 metal binding site [ion binding]; metal-binding site 266835003926 active site 266835003927 I-site; other site 266835003928 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835003929 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 266835003930 putative NAD(P) binding site [chemical binding]; other site 266835003931 putative active site [active] 266835003932 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266835003933 Helix-turn-helix domains; Region: HTH; cl00088 266835003934 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266835003935 dimerization interface [polypeptide binding]; other site 266835003936 substrate binding pocket [chemical binding]; other site 266835003937 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 266835003938 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835003939 binding surface 266835003940 TPR motif; other site 266835003941 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835003942 TPR motif; other site 266835003943 binding surface 266835003944 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835003945 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835003946 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 266835003947 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266835003948 Helix-turn-helix domains; Region: HTH; cl00088 266835003949 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 266835003950 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835003951 substrate binding site [chemical binding]; other site 266835003952 oxyanion hole (OAH) forming residues; other site 266835003953 trimer interface [polypeptide binding]; other site 266835003954 acyl-CoA synthetase; Validated; Region: PRK09088 266835003955 AMP-binding enzyme; Region: AMP-binding; cl15778 266835003956 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266835003957 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 266835003958 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835003959 PAS fold; Region: PAS_3; pfam08447 266835003960 putative active site [active] 266835003961 heme pocket [chemical binding]; other site 266835003962 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835003963 PAS fold; Region: PAS_3; pfam08447 266835003964 putative active site [active] 266835003965 heme pocket [chemical binding]; other site 266835003966 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835003967 metal binding site [ion binding]; metal-binding site 266835003968 active site 266835003969 I-site; other site 266835003970 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835003971 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266835003972 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 266835003973 active site 266835003974 The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693 266835003975 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 266835003976 Helix-turn-helix domains; Region: HTH; cl00088 266835003977 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 266835003978 Helix-turn-helix domains; Region: HTH; cl00088 266835003979 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 266835003980 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 266835003981 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 266835003982 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835003983 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 266835003984 DNA binding site [nucleotide binding] 266835003985 active site 266835003986 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 266835003987 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 266835003988 DNA binding site [nucleotide binding] 266835003989 active site 266835003990 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 266835003991 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835003992 Helix-turn-helix domains; Region: HTH; cl00088 266835003993 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266835003994 putative effector binding pocket; other site 266835003995 dimerization interface [polypeptide binding]; other site 266835003996 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835003997 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 266835003998 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835003999 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 266835004000 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835004001 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266835004002 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 266835004003 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 266835004004 NADP binding site [chemical binding]; other site 266835004005 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 266835004006 Helix-turn-helix domains; Region: HTH; cl00088 266835004007 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 266835004008 DNA polymerase IV; Validated; Region: PRK03858 266835004009 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 266835004010 active site 266835004011 DNA binding site [nucleotide binding] 266835004012 GTPase RsgA; Reviewed; Region: PRK01889 266835004013 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs...; Region: YjeQ_engC; cd01854 266835004014 GTPase/OB domain interface [polypeptide binding]; other site 266835004015 GTPase/Zn-binding domain interface [polypeptide binding]; other site 266835004016 GTP/Mg2+ binding site [chemical binding]; other site 266835004017 G4 box; other site 266835004018 G5 box; other site 266835004019 G1 box; other site 266835004020 Switch I region; other site 266835004021 G2 box; other site 266835004022 G3 box; other site 266835004023 Switch II region; other site 266835004024 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 266835004025 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662 266835004026 nudix motif; other site 266835004027 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835004028 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835004029 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 266835004030 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266835004031 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 266835004032 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266835004033 putative active site [active] 266835004034 short chain dehydrogenase; Provisional; Region: PRK06198 266835004035 classical (c) SDRs; Region: SDR_c; cd05233 266835004036 NAD(P) binding site [chemical binding]; other site 266835004037 active site 266835004038 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 266835004039 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 266835004040 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 266835004041 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266835004042 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 266835004043 putative ligand binding site [chemical binding]; other site 266835004044 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835004045 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 266835004046 Walker A/P-loop; other site 266835004047 ATP binding site [chemical binding]; other site 266835004048 Q-loop/lid; other site 266835004049 ABC transporter signature motif; other site 266835004050 Walker B; other site 266835004051 D-loop; other site 266835004052 H-loop/switch region; other site 266835004053 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 266835004054 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835004055 TM-ABC transporter signature motif; other site 266835004056 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835004057 TM-ABC transporter signature motif; other site 266835004058 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835004059 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 266835004060 NmrA (a transcriptional regulator) and triphenylmethane reductase (TMR) like proteins, subgroup 1, atypical (a) SDRs; Region: NmrA_TMR_like_1_SDR_a; cd05231 266835004061 putative NADP binding site [chemical binding]; other site 266835004062 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266835004063 Helix-turn-helix domains; Region: HTH; cl00088 266835004064 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 266835004065 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266835004066 NADP binding site [chemical binding]; other site 266835004067 active site 266835004068 steroid binding site; other site 266835004069 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835004070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835004071 HerA helicase [Replication, recombination, and repair]; Region: COG0433 266835004072 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835004073 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 266835004074 C-terminal domain interface [polypeptide binding]; other site 266835004075 GSH binding site (G-site) [chemical binding]; other site 266835004076 dimer interface [polypeptide binding]; other site 266835004077 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 266835004078 N-terminal domain interface [polypeptide binding]; other site 266835004079 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835004080 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266835004081 active site 266835004082 catalytic tetrad [active] 266835004083 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 266835004084 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 266835004085 putative NAD(P) binding site [chemical binding]; other site 266835004086 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 266835004087 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 266835004088 Walker A/P-loop; other site 266835004089 ATP binding site [chemical binding]; other site 266835004090 Q-loop/lid; other site 266835004091 ABC transporter signature motif; other site 266835004092 Walker B; other site 266835004093 D-loop; other site 266835004094 H-loop/switch region; other site 266835004095 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_7; cd06316 266835004096 putative ligand binding site [chemical binding]; other site 266835004097 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835004098 TM-ABC transporter signature motif; other site 266835004099 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835004100 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 266835004101 Walker A/P-loop; other site 266835004102 ATP binding site [chemical binding]; other site 266835004103 Q-loop/lid; other site 266835004104 ABC transporter signature motif; other site 266835004105 Walker B; other site 266835004106 D-loop; other site 266835004107 H-loop/switch region; other site 266835004108 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 266835004109 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266835004110 Helix-turn-helix domains; Region: HTH; cl00088 266835004111 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 266835004112 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 266835004113 Helix-turn-helix domains; Region: HTH; cl00088 266835004114 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266835004115 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266835004116 catalytic loop [active] 266835004117 iron binding site [ion binding]; other site 266835004118 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266835004119 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 266835004120 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 266835004121 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266835004122 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 266835004123 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266835004124 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 266835004125 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266835004126 putative NAD(P) binding site [chemical binding]; other site 266835004127 Helix-turn-helix domains; Region: HTH; cl00088 266835004128 transcriptional activator TtdR; Provisional; Region: PRK09801 266835004129 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266835004130 putative effector binding pocket; other site 266835004131 dimerization interface [polypeptide binding]; other site 266835004132 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 266835004133 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 266835004134 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 266835004135 dimer interface [polypeptide binding]; other site 266835004136 active site residues [active] 266835004137 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 266835004138 Helix-turn-helix domains; Region: HTH; cl00088 266835004139 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 266835004140 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 266835004141 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 266835004142 EamA-like transporter family; Region: EamA; cl01037 266835004143 Cupin domain; Region: Cupin_2; cl09118 266835004144 Response regulator receiver domain; Region: Response_reg; pfam00072 266835004145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835004146 active site 266835004147 phosphorylation site [posttranslational modification] 266835004148 intermolecular recognition site; other site 266835004149 dimerization interface [polypeptide binding]; other site 266835004150 OpgC protein; Region: OpgC_C; cl00792 266835004151 Acyltransferase family; Region: Acyl_transf_3; pfam01757 266835004152 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266835004153 active site 266835004154 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266835004155 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266835004156 active site 266835004157 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266835004158 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 266835004159 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835004160 Walker A/P-loop; other site 266835004161 ATP binding site [chemical binding]; other site 266835004162 Q-loop/lid; other site 266835004163 ABC transporter signature motif; other site 266835004164 Walker B; other site 266835004165 D-loop; other site 266835004166 H-loop/switch region; other site 266835004167 Septum formation topological specificity factor MinE; Region: MinE; cl00538 266835004168 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 266835004169 Switch I; other site 266835004170 Switch II; other site 266835004171 septum formation inhibitor; Reviewed; Region: minC; PRK05177 266835004172 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 266835004173 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 266835004174 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835004175 active site 266835004176 catalytic tetrad [active] 266835004177 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835004178 Helix-turn-helix domains; Region: HTH; cl00088 266835004179 Uncharacterized protein conserved in bacteria (DUF2251); Region: DUF2251; cl01770 266835004180 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 266835004181 Transposase domain (DUF772); Region: DUF772; cl15789 266835004182 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 266835004183 BA14K-like protein; Region: BA14K; pfam07886 266835004184 BA14K-like protein; Region: BA14K; pfam07886 266835004185 DoxX; Region: DoxX; cl00976 266835004186 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835004187 TPR motif; other site 266835004188 binding surface 266835004189 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266835004190 Protein of unknown function (DUF680); Region: DUF680; pfam05079 266835004191 Protein of unknown function (DUF680); Region: DUF680; pfam05079 266835004192 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266835004193 AMP-binding enzyme; Region: AMP-binding; cl15778 266835004194 Phosphopantetheine attachment site; Region: PP-binding; cl09936 266835004195 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 266835004196 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 266835004197 putative trimer interface [polypeptide binding]; other site 266835004198 putative CoA binding site [chemical binding]; other site 266835004199 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 266835004200 putative trimer interface [polypeptide binding]; other site 266835004201 putative CoA binding site [chemical binding]; other site 266835004202 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 266835004203 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835004204 Coenzyme A binding pocket [chemical binding]; other site 266835004205 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 266835004206 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 266835004207 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 266835004208 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835004209 FeS/SAM binding site; other site 266835004210 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 266835004211 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266835004212 Helix-turn-helix domains; Region: HTH; cl00088 266835004213 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266835004214 dimerization interface [polypeptide binding]; other site 266835004215 substrate binding pocket [chemical binding]; other site 266835004216 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 266835004217 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 266835004218 NADP binding site [chemical binding]; other site 266835004219 putative substrate binding site [chemical binding]; other site 266835004220 active site 266835004221 Cupin domain; Region: Cupin_2; cl09118 266835004222 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266835004223 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835004224 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 266835004225 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266835004226 NADP binding site [chemical binding]; other site 266835004227 active site 266835004228 steroid binding site; other site 266835004229 short chain dehydrogenase; Provisional; Region: PRK12937 266835004230 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 266835004231 NADP binding site [chemical binding]; other site 266835004232 homodimer interface [polypeptide binding]; other site 266835004233 active site 266835004234 substrate binding site [chemical binding]; other site 266835004235 transcriptional regulator; Provisional; Region: PRK10632 266835004236 Helix-turn-helix domains; Region: HTH; cl00088 266835004237 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 266835004238 putative effector binding pocket; other site 266835004239 putative dimerization interface [polypeptide binding]; other site 266835004240 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266835004241 Type I periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); Region: PBP1_AmiC_like; cd06331 266835004242 ligand binding site [chemical binding]; other site 266835004243 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 266835004244 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266835004245 Zn2+ binding site [ion binding]; other site 266835004246 Mg2+ binding site [ion binding]; other site 266835004247 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 266835004248 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835004249 DNA binding residues [nucleotide binding] 266835004250 dimerization interface [polypeptide binding]; other site 266835004251 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835004252 NmrA-like family; Region: NmrA; pfam05368 266835004253 NAD(P) binding site [chemical binding]; other site 266835004254 active site 266835004255 DoxX; Region: DoxX; cl00976 266835004256 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835004257 Helix-turn-helix domains; Region: HTH; cl00088 266835004258 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 266835004259 putative effector binding pocket; other site 266835004260 putative dimerization interface [polypeptide binding]; other site 266835004261 Predicted deacylase [General function prediction only]; Region: COG3608 266835004262 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 266835004263 putative active site [active] 266835004264 Zn binding site [ion binding]; other site 266835004265 NMT1-like family; Region: NMT1_2; cl15260 266835004266 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 266835004267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 266835004268 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 266835004269 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835004270 DNA binding residues [nucleotide binding] 266835004271 dimerization interface [polypeptide binding]; other site 266835004272 TolB amino-terminal domain; Region: TolB_N; cl00639 266835004273 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 266835004274 TPR motif; other site 266835004275 binding surface 266835004276 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 266835004277 TPR motif; other site 266835004278 binding surface 266835004279 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266835004280 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 266835004281 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 266835004282 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 266835004283 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 266835004284 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 266835004285 active site 266835004286 tetramer interface [polypeptide binding]; other site 266835004287 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835004288 heat shock protein 90; Provisional; Region: PRK05218 266835004289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835004290 ATP binding site [chemical binding]; other site 266835004291 Mg2+ binding site [ion binding]; other site 266835004292 G-X-G motif; other site 266835004293 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835004294 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835004295 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835004296 DNA binding site [nucleotide binding] 266835004297 TolB amino-terminal domain; Region: TolB_N; cl00639 266835004298 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835004299 TPR motif; other site 266835004300 binding surface 266835004301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835004302 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835004303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835004304 dimer interface [polypeptide binding]; other site 266835004305 conserved gate region; other site 266835004306 putative PBP binding loops; other site 266835004307 ABC-ATPase subunit interface; other site 266835004308 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835004309 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835004310 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835004311 Walker A/P-loop; other site 266835004312 ATP binding site [chemical binding]; other site 266835004313 Q-loop/lid; other site 266835004314 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835004315 ABC transporter signature motif; other site 266835004316 Walker B; other site 266835004317 D-loop; other site 266835004318 H-loop/switch region; other site 266835004319 TOBE domain; Region: TOBE_2; cl01440 266835004320 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266835004321 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 266835004322 conserved cys residue [active] 266835004323 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835004324 CHASE domain; Region: CHASE; cl01369 266835004325 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835004326 PAS fold; Region: PAS_3; pfam08447 266835004327 putative active site [active] 266835004328 heme pocket [chemical binding]; other site 266835004329 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835004330 metal binding site [ion binding]; metal-binding site 266835004331 active site 266835004332 I-site; other site 266835004333 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835004334 hypothetical protein; Provisional; Region: PRK06834 266835004335 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835004336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835004337 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835004338 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 266835004339 putative C-terminal domain interface [polypeptide binding]; other site 266835004340 putative GSH binding site (G-site) [chemical binding]; other site 266835004341 putative dimer interface [polypeptide binding]; other site 266835004342 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 266835004343 dimer interface [polypeptide binding]; other site 266835004344 N-terminal domain interface [polypeptide binding]; other site 266835004345 putative substrate binding pocket (H-site) [chemical binding]; other site 266835004346 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 266835004347 putative dimer interface [polypeptide binding]; other site 266835004348 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835004349 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 266835004350 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 266835004351 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835004352 Walker A/P-loop; other site 266835004353 ATP binding site [chemical binding]; other site 266835004354 Q-loop/lid; other site 266835004355 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 266835004356 ABC transporter signature motif; other site 266835004357 Walker B; other site 266835004358 D-loop; other site 266835004359 ABC transporter; Region: ABC_tran_2; pfam12848 266835004360 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 266835004361 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 266835004362 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835004363 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835004364 NAD(P) binding site [chemical binding]; other site 266835004365 active site 266835004366 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835004367 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 266835004368 putative C-terminal domain interface [polypeptide binding]; other site 266835004369 putative GSH binding site (G-site) [chemical binding]; other site 266835004370 putative dimer interface [polypeptide binding]; other site 266835004371 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 266835004372 N-terminal domain interface [polypeptide binding]; other site 266835004373 dimer interface [polypeptide binding]; other site 266835004374 substrate binding pocket (H-site) [chemical binding]; other site 266835004375 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 266835004376 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 266835004377 Cupin domain; Region: Cupin_2; cl09118 266835004378 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266835004379 Helix-turn-helix domains; Region: HTH; cl00088 266835004380 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 266835004381 classical (c) SDRs; Region: SDR_c; cd05233 266835004382 NAD(P) binding site [chemical binding]; other site 266835004383 active site 266835004384 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835004385 Helix-turn-helix domains; Region: HTH; cl00088 266835004386 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266835004387 dimerization interface [polypeptide binding]; other site 266835004388 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 266835004389 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266835004390 putative S-transferase; Provisional; Region: PRK11752 266835004391 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 266835004392 C-terminal domain interface [polypeptide binding]; other site 266835004393 GSH binding site (G-site) [chemical binding]; other site 266835004394 dimer interface [polypeptide binding]; other site 266835004395 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 266835004396 dimer interface [polypeptide binding]; other site 266835004397 N-terminal domain interface [polypeptide binding]; other site 266835004398 active site 266835004399 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 266835004400 Exopolysaccharide production repressor; Region: SyrA; pfam11089 266835004401 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 266835004402 cytosine deaminase; Provisional; Region: PRK05985 266835004403 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 266835004404 active site 266835004405 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 266835004406 catalytic triad [active] 266835004407 mobile mystery protein B; Region: mob_myst_B; TIGR02613 266835004408 Fic/DOC family; Region: Fic; cl00960 266835004409 mobile mystery protein A; Region: mob_myst_A; TIGR02612 266835004410 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835004411 non-specific DNA binding site [nucleotide binding]; other site 266835004412 salt bridge; other site 266835004413 sequence-specific DNA binding site [nucleotide binding]; other site 266835004414 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 266835004415 structural tetrad; other site 266835004416 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 266835004417 putative phosphate binding site [ion binding]; other site 266835004418 putative catalytic site [active] 266835004419 active site 266835004420 metal binding site A [ion binding]; metal-binding site 266835004421 DNA binding site [nucleotide binding] 266835004422 putative AP binding site [nucleotide binding]; other site 266835004423 putative metal binding site B [ion binding]; other site 266835004424 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 266835004425 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835004426 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835004427 binding surface 266835004428 TPR motif; other site 266835004429 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 266835004430 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 266835004431 putative DNA binding site [nucleotide binding]; other site 266835004432 putative homodimer interface [polypeptide binding]; other site 266835004433 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 266835004434 GIY-YIG motif/motif A; other site 266835004435 putative active site [active] 266835004436 putative metal binding site [ion binding]; other site 266835004437 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 266835004438 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 266835004439 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 266835004440 active site 266835004441 DNA binding site [nucleotide binding] 266835004442 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 266835004443 DNA binding site [nucleotide binding] 266835004444 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 266835004445 nucleotide binding site [chemical binding]; other site 266835004446 EthD protein; Region: EthD; cl06234 266835004447 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 266835004448 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 266835004449 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266835004450 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266835004451 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 266835004452 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266835004453 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 266835004454 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 266835004455 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 266835004456 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 266835004457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835004458 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 266835004459 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266835004460 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835004461 DNA binding site [nucleotide binding] 266835004462 domain linker motif; other site 266835004463 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266835004464 dimerization interface [polypeptide binding]; other site 266835004465 ligand binding site [chemical binding]; other site 266835004466 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266835004467 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835004468 CsbD-like; Region: CsbD; cl15799 266835004469 hydroperoxidase II; Provisional; Region: katE; PRK11249 266835004470 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 266835004471 heme binding pocket [chemical binding]; other site 266835004472 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 266835004473 domain interactions; other site 266835004474 Low affinity iron permease; Region: Iron_permease; cl12096 266835004475 Low affinity iron permease; Region: Iron_permease; cl12096 266835004476 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266835004477 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266835004478 ligand binding site [chemical binding]; other site 266835004479 flexible hinge region; other site 266835004480 Helix-turn-helix domains; Region: HTH; cl00088 266835004481 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835004482 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835004483 DNA-binding site [nucleotide binding]; DNA binding site 266835004484 FCD domain; Region: FCD; cl11656 266835004485 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 266835004486 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266835004487 putative NAD(P) binding site [chemical binding]; other site 266835004488 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 266835004489 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266835004490 NADP binding site [chemical binding]; other site 266835004491 active site 266835004492 steroid binding site; other site 266835004493 Helix-turn-helix domains; Region: HTH; cl00088 266835004494 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 266835004495 OpgC protein; Region: OpgC_C; cl00792 266835004496 Acyltransferase family; Region: Acyl_transf_3; pfam01757 266835004497 Protein of unknown function (DUF1376); Region: DUF1376; cl01531 266835004498 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835004499 non-specific DNA binding site [nucleotide binding]; other site 266835004500 salt bridge; other site 266835004501 sequence-specific DNA binding site [nucleotide binding]; other site 266835004502 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 266835004503 Catalytic site [active] 266835004504 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266835004505 catalytic core [active] 266835004506 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835004507 TM-ABC transporter signature motif; other site 266835004508 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835004509 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 266835004510 Walker A/P-loop; other site 266835004511 ATP binding site [chemical binding]; other site 266835004512 Q-loop/lid; other site 266835004513 ABC transporter signature motif; other site 266835004514 Walker B; other site 266835004515 D-loop; other site 266835004516 H-loop/switch region; other site 266835004517 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 266835004518 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266835004519 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 266835004520 YcfA-like protein; Region: YcfA; cl00752 266835004521 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 266835004522 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 266835004523 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835004524 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 266835004525 putative NAD(P) binding site [chemical binding]; other site 266835004526 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 266835004527 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 266835004528 putative hydrophobic ligand binding site [chemical binding]; other site 266835004529 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 266835004530 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 266835004531 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266835004532 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835004533 dimerization interface [polypeptide binding]; other site 266835004534 putative DNA binding site [nucleotide binding]; other site 266835004535 putative Zn2+ binding site [ion binding]; other site 266835004536 YeeE/YedE family (DUF395); Region: DUF395; cl01018 266835004537 Predicted transporter component [General function prediction only]; Region: COG2391 266835004538 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 266835004539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835004540 S-adenosylmethionine binding site [chemical binding]; other site 266835004541 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266835004542 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835004543 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835004544 dimerization interface [polypeptide binding]; other site 266835004545 putative DNA binding site [nucleotide binding]; other site 266835004546 putative Zn2+ binding site [ion binding]; other site 266835004547 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 266835004548 ArsC family; Region: ArsC; pfam03960 266835004549 catalytic residues [active] 266835004550 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 266835004551 amphipathic channel; other site 266835004552 Asn-Pro-Ala signature motifs; other site 266835004553 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835004554 dimerization interface [polypeptide binding]; other site 266835004555 putative DNA binding site [nucleotide binding]; other site 266835004556 putative Zn2+ binding site [ion binding]; other site 266835004557 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835004558 Helix-turn-helix domains; Region: HTH; cl00088 266835004559 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 266835004560 putative effector binding pocket; other site 266835004561 putative dimerization interface [polypeptide binding]; other site 266835004562 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 266835004563 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835004564 active site 266835004565 catalytic tetrad [active] 266835004566 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835004567 dimerization interface [polypeptide binding]; other site 266835004568 putative DNA binding site [nucleotide binding]; other site 266835004569 putative Zn2+ binding site [ion binding]; other site 266835004570 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 266835004571 putative hydrophobic ligand binding site [chemical binding]; other site 266835004572 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835004573 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 266835004574 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 266835004575 active site 266835004576 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 266835004577 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266835004578 short chain dehydrogenase; Provisional; Region: PRK12829 266835004579 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835004580 active site 266835004581 RNA polymerase sigma-70 factor, TIGR02960 family; Region: SigX5 266835004582 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835004583 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835004584 DNA binding residues [nucleotide binding] 266835004585 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266835004586 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 266835004587 active site 266835004588 metal binding site [ion binding]; metal-binding site 266835004589 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835004590 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266835004591 catalytic core [active] 266835004592 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 266835004593 Sulfatase; Region: Sulfatase; cl10460 266835004594 Protein of unknown function (DUF535); Region: DUF535; cl01128 266835004595 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 266835004596 active site 266835004597 substrate binding site [chemical binding]; other site 266835004598 trimer interface [polypeptide binding]; other site 266835004599 CoA binding site [chemical binding]; other site 266835004600 Helix-turn-helix domains; Region: HTH; cl00088 266835004601 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835004602 dimerization interface [polypeptide binding]; other site 266835004603 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835004604 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 266835004605 NADP binding site [chemical binding]; other site 266835004606 substrate binding site [chemical binding]; other site 266835004607 active site 266835004608 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 266835004609 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266835004610 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835004611 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835004612 Helix-turn-helix domains; Region: HTH; cl00088 266835004613 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 266835004614 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835004615 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266835004616 substrate binding pocket [chemical binding]; other site 266835004617 membrane-bound complex binding site; other site 266835004618 hinge residues; other site 266835004619 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266835004620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835004621 dimer interface [polypeptide binding]; other site 266835004622 conserved gate region; other site 266835004623 putative PBP binding loops; other site 266835004624 ABC-ATPase subunit interface; other site 266835004625 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266835004626 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 266835004627 Walker A/P-loop; other site 266835004628 ATP binding site [chemical binding]; other site 266835004629 Q-loop/lid; other site 266835004630 ABC transporter signature motif; other site 266835004631 Walker B; other site 266835004632 D-loop; other site 266835004633 H-loop/switch region; other site 266835004634 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 266835004635 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835004636 binding surface 266835004637 TPR motif; other site 266835004638 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 266835004639 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835004640 binding surface 266835004641 TPR motif; other site 266835004642 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835004643 binding surface 266835004644 TPR motif; other site 266835004645 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835004646 binding surface 266835004647 TPR motif; other site 266835004648 Lipoprotein NlpI, contains TPR repeats [General function prediction only]; Region: NlpI; COG4785 266835004649 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835004650 binding surface 266835004651 TPR motif; other site 266835004652 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835004653 binding surface 266835004654 TPR motif; other site 266835004655 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835004656 binding surface 266835004657 TPR motif; other site 266835004658 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835004659 binding surface 266835004660 TPR motif; other site 266835004661 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835004662 binding surface 266835004663 TPR motif; other site 266835004664 lipoprotein NlpI; Provisional; Region: PRK11189 266835004665 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 266835004666 FMN binding site [chemical binding]; other site 266835004667 active site 266835004668 substrate binding site [chemical binding]; other site 266835004669 catalytic residue [active] 266835004670 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835004671 dimerization interface [polypeptide binding]; other site 266835004672 putative DNA binding site [nucleotide binding]; other site 266835004673 putative Zn2+ binding site [ion binding]; other site 266835004674 RES domain; Region: RES; cl02411 266835004675 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 266835004676 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 266835004677 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835004678 NAD binding site [chemical binding]; other site 266835004679 catalytic residues [active] 266835004680 Uncharacterized conserved protein [Function unknown]; Region: COG3603 266835004681 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 266835004682 putative acetyltransferase; Provisional; Region: PRK03624 266835004683 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835004684 Coenzyme A binding pocket [chemical binding]; other site 266835004685 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266835004686 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 266835004687 GAF domain; Region: GAF; cl00853 266835004688 GYD domain; Region: GYD; cl01743 266835004689 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 266835004690 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 266835004691 ring oligomerisation interface [polypeptide binding]; other site 266835004692 ATP/Mg binding site [chemical binding]; other site 266835004693 stacking interactions; other site 266835004694 hinge regions; other site 266835004695 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 266835004696 oligomerisation interface [polypeptide binding]; other site 266835004697 mobile loop; other site 266835004698 roof hairpin; other site 266835004699 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 266835004700 putative diguanylate cyclase; Provisional; Region: PRK09776 266835004701 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835004702 metal binding site [ion binding]; metal-binding site 266835004703 active site 266835004704 I-site; other site 266835004705 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266835004706 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835004707 DNA binding site [nucleotide binding] 266835004708 domain linker motif; other site 266835004709 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266835004710 dimerization interface [polypeptide binding]; other site 266835004711 ligand binding site [chemical binding]; other site 266835004712 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835004713 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835004714 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 266835004715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835004716 putative PBP binding loops; other site 266835004717 ABC-ATPase subunit interface; other site 266835004718 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835004719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835004720 dimer interface [polypeptide binding]; other site 266835004721 conserved gate region; other site 266835004722 putative PBP binding loops; other site 266835004723 ABC-ATPase subunit interface; other site 266835004724 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 266835004725 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 266835004726 OpgC protein; Region: OpgC_C; cl00792 266835004727 Protein of unknown function (DUF419); Region: DUF419; cl15265 266835004728 Protein of unknown function (DUF419); Region: DUF419; cl15265 266835004729 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835004730 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 266835004731 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 266835004732 putative hydrophobic ligand binding site [chemical binding]; other site 266835004733 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835004734 dimerization interface [polypeptide binding]; other site 266835004735 putative DNA binding site [nucleotide binding]; other site 266835004736 putative Zn2+ binding site [ion binding]; other site 266835004737 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 266835004738 putative active site pocket [active] 266835004739 dimerization interface [polypeptide binding]; other site 266835004740 putative catalytic residue [active] 266835004741 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266835004742 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 266835004743 putative dimer interface [polypeptide binding]; other site 266835004744 Helix-turn-helix domains; Region: HTH; cl00088 266835004745 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 266835004746 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835004747 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835004748 Helix-turn-helix domains; Region: HTH; cl00088 266835004749 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266835004750 dimerization interface [polypeptide binding]; other site 266835004751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835004752 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835004753 Eukaryotic cytochrome b(561); Region: Cyt_b561; cl14616 266835004754 putative heme binding sites [chemical binding]; other site 266835004755 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 266835004756 Predicted lysozyme (DUF847); Region: DUF847; pfam05838 266835004757 Predicted integral membrane protein (DUF2270); Region: DUF2270; cl02337 266835004758 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 266835004759 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 266835004760 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835004761 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 266835004762 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835004763 DNA binding residues [nucleotide binding] 266835004764 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266835004765 classical (c) SDRs; Region: SDR_c; cd05233 266835004766 NAD(P) binding site [chemical binding]; other site 266835004767 active site 266835004768 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 266835004769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835004770 dimer interface [polypeptide binding]; other site 266835004771 conserved gate region; other site 266835004772 putative PBP binding loops; other site 266835004773 ABC-ATPase subunit interface; other site 266835004774 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835004775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835004776 ABC-ATPase subunit interface; other site 266835004777 putative PBP binding loops; other site 266835004778 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835004779 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 266835004780 Domain of unknown function (DUF427); Region: DUF427; cl00998 266835004781 Domain of unknown function (DUF427); Region: DUF427; cl00998 266835004782 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266835004783 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266835004784 active site 266835004785 non-prolyl cis peptide bond; other site 266835004786 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266835004787 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835004788 Walker A/P-loop; other site 266835004789 ATP binding site [chemical binding]; other site 266835004790 Q-loop/lid; other site 266835004791 ABC transporter signature motif; other site 266835004792 Walker B; other site 266835004793 D-loop; other site 266835004794 H-loop/switch region; other site 266835004795 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835004796 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835004797 Walker A/P-loop; other site 266835004798 ATP binding site [chemical binding]; other site 266835004799 Q-loop/lid; other site 266835004800 ABC transporter signature motif; other site 266835004801 Walker B; other site 266835004802 D-loop; other site 266835004803 H-loop/switch region; other site 266835004804 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835004805 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; cl01562 266835004806 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 266835004807 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835004808 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 266835004809 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 266835004810 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266835004811 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 266835004812 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266835004813 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266835004814 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 266835004815 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266835004816 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 266835004817 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 266835004818 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 266835004819 putative hydrophobic ligand binding site [chemical binding]; other site 266835004820 Cation efflux family; Region: Cation_efflux; cl00316 266835004821 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 266835004822 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like3; cd05668 266835004823 metal binding site [ion binding]; metal-binding site 266835004824 putative dimer interface [polypeptide binding]; other site 266835004825 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835004826 metal binding site [ion binding]; metal-binding site 266835004827 active site 266835004828 I-site; other site 266835004829 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835004830 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835004831 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266835004832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835004833 active site 266835004834 phosphorylation site [posttranslational modification] 266835004835 intermolecular recognition site; other site 266835004836 dimerization interface [polypeptide binding]; other site 266835004837 Response regulator receiver domain; Region: Response_reg; pfam00072 266835004838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835004839 active site 266835004840 phosphorylation site [posttranslational modification] 266835004841 intermolecular recognition site; other site 266835004842 dimerization interface [polypeptide binding]; other site 266835004843 PAS domain; Region: PAS_9; pfam13426 266835004844 Histidine kinase; Region: HisKA_2; cl06527 266835004845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835004846 ATP binding site [chemical binding]; other site 266835004847 Mg2+ binding site [ion binding]; other site 266835004848 G-X-G motif; other site 266835004849 Guanosine kinase-like sugar kinases. Found in bacteria and archaea, the guanosine kinase-like group is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: Guanosine_kinase_like; cd01947 266835004850 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266835004851 substrate binding site [chemical binding]; other site 266835004852 ATP binding site [chemical binding]; other site 266835004853 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 266835004854 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266835004855 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 266835004856 active site 266835004857 amidase; Validated; Region: PRK06565 266835004858 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 266835004859 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 266835004860 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 266835004861 trimer interface [polypeptide binding]; other site 266835004862 active site 266835004863 substrate binding site [chemical binding]; other site 266835004864 CoA binding site [chemical binding]; other site 266835004865 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 266835004866 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266835004867 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 266835004868 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835004869 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266835004870 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266835004871 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835004872 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 266835004873 NAD(P) binding site [chemical binding]; other site 266835004874 catalytic residues [active] 266835004875 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266835004876 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266835004877 active site pocket [active] 266835004878 NIPSNAP; Region: NIPSNAP; pfam07978 266835004879 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 266835004880 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266835004881 active site pocket [active] 266835004882 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266835004883 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266835004884 active site pocket [active] 266835004885 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835004886 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835004887 DNA-binding site [nucleotide binding]; DNA binding site 266835004888 FCD domain; Region: FCD; cl11656 266835004889 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835004890 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835004891 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 266835004892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835004893 dimer interface [polypeptide binding]; other site 266835004894 conserved gate region; other site 266835004895 putative PBP binding loops; other site 266835004896 ABC-ATPase subunit interface; other site 266835004897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835004898 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835004899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835004900 dimer interface [polypeptide binding]; other site 266835004901 conserved gate region; other site 266835004902 putative PBP binding loops; other site 266835004903 ABC-ATPase subunit interface; other site 266835004904 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266835004905 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 266835004906 Walker A/P-loop; other site 266835004907 ATP binding site [chemical binding]; other site 266835004908 Q-loop/lid; other site 266835004909 ABC transporter signature motif; other site 266835004910 Walker B; other site 266835004911 D-loop; other site 266835004912 H-loop/switch region; other site 266835004913 TOBE domain; Region: TOBE_2; cl01440 266835004914 galactonate dehydratase; Provisional; Region: PRK14017 266835004915 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266835004916 active site pocket [active] 266835004917 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 266835004918 Flavin Reductases; Region: FlaRed; cl00801 266835004919 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 266835004920 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835004921 Walker A motif; other site 266835004922 ATP binding site [chemical binding]; other site 266835004923 Walker B motif; other site 266835004924 arginine finger; other site 266835004925 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835004926 Walker A motif; other site 266835004927 ATP binding site [chemical binding]; other site 266835004928 Walker B motif; other site 266835004929 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 266835004930 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 266835004931 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 266835004932 Protein of unknown function (DUF770); Region: DUF770; cl01402 266835004933 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 266835004934 Protein of unknown function (DUF877); Region: DUF877; pfam05943 266835004935 Protein of unknown function (DUF796); Region: DUF796; cl01226 266835004936 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 266835004937 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 266835004938 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 266835004939 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 266835004940 Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular transport; Signal transduction mechanisms]; Region: COG3456 266835004941 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 266835004942 phosphopeptide binding site; other site 266835004943 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 266835004944 Bacterial protein of unknown function (DUF876); Region: DUF876; cl01406 266835004945 hypothetical protein; Provisional; Region: PRK07033 266835004946 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 266835004947 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266835004948 ligand binding site [chemical binding]; other site 266835004949 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 266835004950 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 266835004951 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 266835004952 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 266835004953 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 266835004954 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 266835004955 Beta-ketoacyl synthase, N-terminal domain; Region: ketoacyl-synt; cl09934 266835004956 PAAR motif; Region: PAAR_motif; cl15808 266835004957 conserved hypothetical protein; Region: TIGR02270 266835004958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 266835004959 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 266835004960 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 266835004961 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 266835004962 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 266835004963 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 266835004964 phosphopeptide binding site; other site 266835004965 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 266835004966 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266835004967 ligand binding site [chemical binding]; other site 266835004968 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 266835004969 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 266835004970 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 266835004971 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 266835004972 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 266835004973 Protein phosphatase 2C; Region: PP2C; pfam00481 266835004974 active site 266835004975 Protein kinase domain; Region: Pkinase; pfam00069 266835004976 Catalytic domain of Protein Kinases; Region: PKc; cd00180 266835004977 active site 266835004978 ATP binding site [chemical binding]; other site 266835004979 substrate binding site [chemical binding]; other site 266835004980 activation loop (A-loop); other site 266835004981 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 266835004982 Protein of unknown function (DUF1036); Region: DUF1036; cl02296 266835004983 Peptidase family M23; Region: Peptidase_M23; pfam01551 266835004984 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 266835004985 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 266835004986 substrate pocket [chemical binding]; other site 266835004987 active site 266835004988 dimer interface [polypeptide binding]; other site 266835004989 proteolytic cleavage site; other site 266835004990 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266835004991 ligand binding site [chemical binding]; other site 266835004992 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 266835004993 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 266835004994 substrate pocket [chemical binding]; other site 266835004995 active site 266835004996 dimer interface [polypeptide binding]; other site 266835004997 proteolytic cleavage site; other site 266835004998 YceI-like domain; Region: YceI; cl01001 266835004999 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266835005000 ligand binding site [chemical binding]; other site 266835005001 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 266835005002 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 266835005003 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 266835005004 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266835005005 Uncharacterized conserved protein [Function unknown]; Region: HdeD; cl01277 266835005006 Response regulator receiver domain; Region: Response_reg; pfam00072 266835005007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835005008 active site 266835005009 phosphorylation site [posttranslational modification] 266835005010 intermolecular recognition site; other site 266835005011 dimerization interface [polypeptide binding]; other site 266835005012 PAS fold; Region: PAS_3; pfam08447 266835005013 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835005014 putative active site [active] 266835005015 heme pocket [chemical binding]; other site 266835005016 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835005017 dimer interface [polypeptide binding]; other site 266835005018 phosphorylation site [posttranslational modification] 266835005019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835005020 ATP binding site [chemical binding]; other site 266835005021 Mg2+ binding site [ion binding]; other site 266835005022 G-X-G motif; other site 266835005023 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266835005024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835005025 active site 266835005026 phosphorylation site [posttranslational modification] 266835005027 intermolecular recognition site; other site 266835005028 dimerization interface [polypeptide binding]; other site 266835005029 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266835005030 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266835005031 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266835005032 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266835005033 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266835005034 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266835005035 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266835005036 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266835005037 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 266835005038 flagellar assembly protein H; Validated; Region: fliH; PRK06800 266835005039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835005040 ATP binding site [chemical binding]; other site 266835005041 Mg2+ binding site [ion binding]; other site 266835005042 G-X-G motif; other site 266835005043 Response regulator receiver domain; Region: Response_reg; pfam00072 266835005044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835005045 active site 266835005046 phosphorylation site [posttranslational modification] 266835005047 intermolecular recognition site; other site 266835005048 dimerization interface [polypeptide binding]; other site 266835005049 Response regulator receiver domain; Region: Response_reg; pfam00072 266835005050 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835005051 active site 266835005052 phosphorylation site [posttranslational modification] 266835005053 intermolecular recognition site; other site 266835005054 dimerization interface [polypeptide binding]; other site 266835005055 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266835005056 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 266835005057 putative dimer interface [polypeptide binding]; other site 266835005058 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266835005059 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 266835005060 putative dimer interface [polypeptide binding]; other site 266835005061 Usg-like family; Region: Usg; cl11567 266835005062 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 266835005063 oligomerisation interface [polypeptide binding]; other site 266835005064 mobile loop; other site 266835005065 roof hairpin; other site 266835005066 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 266835005067 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 266835005068 ring oligomerisation interface [polypeptide binding]; other site 266835005069 ATP/Mg binding site [chemical binding]; other site 266835005070 stacking interactions; other site 266835005071 hinge regions; other site 266835005072 Helix-turn-helix domains; Region: HTH; cl00088 266835005073 Heme NO binding; Region: HNOB; cl15268 266835005074 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 266835005075 Patatin phospholipase; Region: DUF3734; pfam12536 266835005076 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 266835005077 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835005078 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 266835005079 NAD(P) binding site [chemical binding]; other site 266835005080 active site 266835005081 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266835005082 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 266835005083 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 266835005084 nucleophile elbow; other site 266835005085 Protein of unknown function (DUF541); Region: SIMPL; cl01077 266835005086 Flagellin N-methylase; Region: FliB; cl00497 266835005087 K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927 266835005088 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 266835005089 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266835005090 ligand binding site [chemical binding]; other site 266835005091 short chain dehydrogenase; Provisional; Region: PRK08278 266835005092 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 266835005093 NAD(P) binding site [chemical binding]; other site 266835005094 homodimer interface [polypeptide binding]; other site 266835005095 active site 266835005096 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835005097 DNA binding residues [nucleotide binding] 266835005098 dimerization interface [polypeptide binding]; other site 266835005099 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 266835005100 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266835005101 protein binding site [polypeptide binding]; other site 266835005102 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 266835005103 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266835005104 protein binding site [polypeptide binding]; other site 266835005105 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 266835005106 putative dimer interface [polypeptide binding]; other site 266835005107 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835005108 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835005109 Helix-turn-helix domains; Region: HTH; cl00088 266835005110 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835005111 Helix-turn-helix domains; Region: HTH; cl00088 266835005112 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835005113 dimerization interface [polypeptide binding]; other site 266835005114 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 266835005115 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15375 266835005116 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 266835005117 AzlC protein; Region: AzlC; cl00570 266835005118 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835005119 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835005120 putative DNA binding site [nucleotide binding]; other site 266835005121 putative Zn2+ binding site [ion binding]; other site 266835005122 Helix-turn-helix domains; Region: HTH; cl00088 266835005123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835005124 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835005125 putative substrate translocation pore; other site 266835005126 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 266835005127 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 266835005128 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 266835005129 dimer interface [polypeptide binding]; other site 266835005130 decamer (pentamer of dimers) interface [polypeptide binding]; other site 266835005131 catalytic triad [active] 266835005132 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 266835005133 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266835005134 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835005135 DNA-binding site [nucleotide binding]; DNA binding site 266835005136 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835005137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835005138 homodimer interface [polypeptide binding]; other site 266835005139 catalytic residue [active] 266835005140 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835005141 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835005142 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266835005143 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 266835005144 putative ligand binding site [chemical binding]; other site 266835005145 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835005146 TM-ABC transporter signature motif; other site 266835005147 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266835005148 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 266835005149 Walker A/P-loop; other site 266835005150 ATP binding site [chemical binding]; other site 266835005151 Q-loop/lid; other site 266835005152 ABC transporter signature motif; other site 266835005153 Walker B; other site 266835005154 D-loop; other site 266835005155 H-loop/switch region; other site 266835005156 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 266835005157 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835005158 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835005159 FAD dependent oxidoreductase; Region: DAO; pfam01266 266835005160 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835005161 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 266835005162 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835005163 Transcriptional activator HlyU; Region: HlyU; cl02273 266835005164 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835005165 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835005166 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835005167 Helix-turn-helix domains; Region: HTH; cl00088 266835005168 WHG domain; Region: WHG; pfam13305 266835005169 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 266835005170 yiaA/B two helix domain; Region: YiaAB; cl01759 266835005171 Helix-turn-helix domains; Region: HTH; cl00088 266835005172 Protein of unknown function, DUF393; Region: DUF393; cl01136 266835005173 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 266835005174 Domain of unknown function (DUF333); Region: DUF333; pfam03891 266835005175 GYD domain; Region: GYD; cl01743 266835005176 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 266835005177 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 266835005178 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 266835005179 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 266835005180 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835005181 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 266835005182 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835005183 DNA binding residues [nucleotide binding] 266835005184 DNA primase; Validated; Region: dnaG; PRK05667 266835005185 CHC2 zinc finger; Region: zf-CHC2; cl15369 266835005186 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 266835005187 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 266835005188 active site 266835005189 metal binding site [ion binding]; metal-binding site 266835005190 interdomain interaction site; other site 266835005191 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 266835005192 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 266835005193 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 266835005194 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 266835005195 PhoU domain; Region: PhoU; pfam01895 266835005196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835005197 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835005198 putative substrate translocation pore; other site 266835005199 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835005200 Helix-turn-helix domains; Region: HTH; cl00088 266835005201 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 266835005202 putative effector binding pocket; other site 266835005203 putative dimerization interface [polypeptide binding]; other site 266835005204 short chain dehydrogenase; Provisional; Region: PRK06482 266835005205 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266835005206 NADP binding site [chemical binding]; other site 266835005207 active site 266835005208 steroid binding site; other site 266835005209 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266835005210 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 266835005211 metal-binding site [ion binding] 266835005212 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266835005213 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 266835005214 DNA binding residues [nucleotide binding] 266835005215 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 266835005216 dimer interface [polypeptide binding]; other site 266835005217 putative metal binding site [ion binding]; other site 266835005218 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 266835005219 homodimer interface [polypeptide binding]; other site 266835005220 homotetramer interface [polypeptide binding]; other site 266835005221 active site pocket [active] 266835005222 cleavage site 266835005223 Predicted acetyltransferase [General function prediction only]; Region: COG3981 266835005224 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835005225 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 266835005226 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835005227 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 266835005228 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835005229 Helix-turn-helix domains; Region: HTH; cl00088 266835005230 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835005231 dimerization interface [polypeptide binding]; other site 266835005232 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 266835005233 Helix-turn-helix domains; Region: HTH; cl00088 266835005234 GatB domain; Region: GatB_Yqey; cl11497 266835005235 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 266835005236 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 266835005237 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 266835005238 catalytic site [active] 266835005239 subunit interface [polypeptide binding]; other site 266835005240 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835005241 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266835005242 active site 266835005243 catalytic tetrad [active] 266835005244 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835005245 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835005246 putative substrate translocation pore; other site 266835005247 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 266835005248 manganese transport regulator MntR; Provisional; Region: PRK11050 266835005249 Helix-turn-helix domains; Region: HTH; cl00088 266835005250 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 266835005251 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 266835005252 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 266835005253 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 266835005254 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835005255 S-adenosylmethionine binding site [chemical binding]; other site 266835005256 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 266835005257 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835005258 Helix-turn-helix domains; Region: HTH; cl00088 266835005259 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835005260 dimerization interface [polypeptide binding]; other site 266835005261 LysE type translocator; Region: LysE; cl00565 266835005262 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 266835005263 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835005264 NAD(P) binding site [chemical binding]; other site 266835005265 active site 266835005266 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266835005267 Helix-turn-helix domains; Region: HTH; cl00088 266835005268 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266835005269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835005270 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835005271 putative DNA binding site [nucleotide binding]; other site 266835005272 putative Zn2+ binding site [ion binding]; other site 266835005273 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 266835005274 nucleoside/Zn binding site; other site 266835005275 dimer interface [polypeptide binding]; other site 266835005276 catalytic motif [active] 266835005277 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266835005278 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266835005279 active site 266835005280 metal binding site [ion binding]; metal-binding site 266835005281 Bacterial SH3 domain; Region: SH3_3; cl02551 266835005282 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 266835005283 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266835005284 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 266835005285 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266835005286 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 266835005287 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 266835005288 IMP binding site; other site 266835005289 dimer interface [polypeptide binding]; other site 266835005290 interdomain contacts; other site 266835005291 partial ornithine binding site; other site 266835005292 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266835005293 homotrimer interaction site [polypeptide binding]; other site 266835005294 putative active site [active] 266835005295 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266835005296 homotrimer interaction site [polypeptide binding]; other site 266835005297 putative active site [active] 266835005298 Cupin domain; Region: Cupin_2; cl09118 266835005299 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 266835005300 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 266835005301 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835005302 Coenzyme A binding pocket [chemical binding]; other site 266835005303 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 266835005304 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266835005305 catalytic residue [active] 266835005306 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 266835005307 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 266835005308 DNA binding site [nucleotide binding] 266835005309 active site 266835005310 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 266835005311 DNA-binding site [nucleotide binding]; DNA binding site 266835005312 RNA-binding motif; other site 266835005313 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 266835005314 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835005315 Helix-turn-helix domains; Region: HTH; cl00088 266835005316 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 266835005317 putative effector binding pocket; other site 266835005318 putative dimerization interface [polypeptide binding]; other site 266835005319 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266835005320 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266835005321 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835005322 NAD(P) binding site [chemical binding]; other site 266835005323 active site 266835005324 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835005325 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 266835005326 putative C-terminal domain interface [polypeptide binding]; other site 266835005327 putative GSH binding site (G-site) [chemical binding]; other site 266835005328 putative dimer interface [polypeptide binding]; other site 266835005329 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 266835005330 N-terminal domain interface [polypeptide binding]; other site 266835005331 dimer interface [polypeptide binding]; other site 266835005332 substrate binding pocket (H-site) [chemical binding]; other site 266835005333 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835005334 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835005335 aspartate aminotransferase; Provisional; Region: PRK05764 266835005336 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835005337 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835005338 homodimer interface [polypeptide binding]; other site 266835005339 catalytic residue [active] 266835005340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835005341 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835005342 putative substrate translocation pore; other site 266835005343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835005344 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835005345 Helix-turn-helix domains; Region: HTH; cl00088 266835005346 Cupin domain; Region: Cupin_2; cl09118 266835005347 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835005348 metal binding site [ion binding]; metal-binding site 266835005349 active site 266835005350 I-site; other site 266835005351 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835005352 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 266835005353 elongation factor G; Reviewed; Region: PRK12740 266835005354 G1 box; other site 266835005355 putative GEF interaction site [polypeptide binding]; other site 266835005356 GTP/Mg2+ binding site [chemical binding]; other site 266835005357 Switch I region; other site 266835005358 G2 box; other site 266835005359 G3 box; other site 266835005360 Switch II region; other site 266835005361 G4 box; other site 266835005362 G5 box; other site 266835005363 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 266835005364 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 266835005365 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 266835005366 Phospholipid methyltransferase; Region: PEMT; cl00763 266835005367 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835005368 Helix-turn-helix domains; Region: HTH; cl00088 266835005369 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266835005370 putative effector binding pocket; other site 266835005371 dimerization interface [polypeptide binding]; other site 266835005372 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 266835005373 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266835005374 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835005375 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835005376 dimerization interface [polypeptide binding]; other site 266835005377 putative DNA binding site [nucleotide binding]; other site 266835005378 putative Zn2+ binding site [ion binding]; other site 266835005379 Helix-turn-helix domains; Region: HTH; cl00088 266835005380 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 266835005381 putative metal binding site; other site 266835005382 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 266835005383 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266835005384 active site 266835005385 motif I; other site 266835005386 motif II; other site 266835005387 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 266835005388 dimer interface [polypeptide binding]; other site 266835005389 active site 266835005390 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 266835005391 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 266835005392 putative ribose interaction site [chemical binding]; other site 266835005393 putative ADP binding site [chemical binding]; other site 266835005394 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266835005395 active site 266835005396 nucleotide binding site [chemical binding]; other site 266835005397 HIGH motif; other site 266835005398 KMSKS motif; other site 266835005399 LysE type translocator; Region: LysE; cl00565 266835005400 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 266835005401 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 266835005402 NADP binding site [chemical binding]; other site 266835005403 homopentamer interface [polypeptide binding]; other site 266835005404 substrate binding site [chemical binding]; other site 266835005405 active site 266835005406 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 266835005407 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 266835005408 putative active site [active] 266835005409 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 266835005410 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 266835005411 putative active site [active] 266835005412 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 266835005413 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 266835005414 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 266835005415 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835005416 binding surface 266835005417 TPR motif; other site 266835005418 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 266835005419 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 266835005420 LssY C-terminus; Region: LssY_C; pfam14067 266835005421 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 266835005422 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266835005423 putative NAD(P) binding site [chemical binding]; other site 266835005424 transcriptional regulator; Provisional; Region: PRK10632 266835005425 Helix-turn-helix domains; Region: HTH; cl00088 266835005426 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 266835005427 putative effector binding pocket; other site 266835005428 putative dimerization interface [polypeptide binding]; other site 266835005429 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 266835005430 Domain of unknown function DUF21; Region: DUF21; pfam01595 266835005431 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 266835005432 Transporter associated domain; Region: CorC_HlyC; cl08393 266835005433 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 266835005434 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 266835005435 This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export...; Region: ABCC_Protease_Secretion; cd03246 266835005436 Walker A/P-loop; other site 266835005437 ATP binding site [chemical binding]; other site 266835005438 Q-loop/lid; other site 266835005439 ABC transporter signature motif; other site 266835005440 Walker B; other site 266835005441 D-loop; other site 266835005442 H-loop/switch region; other site 266835005443 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 266835005444 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 266835005445 active site 266835005446 catalytic residues [active] 266835005447 YCII-related domain; Region: YCII; cl00999 266835005448 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 266835005449 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835005450 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266835005451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835005452 putative substrate translocation pore; other site 266835005453 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 266835005454 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266835005455 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266835005456 Helix-turn-helix domains; Region: HTH; cl00088 266835005457 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266835005458 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 266835005459 NAD(P) binding site [chemical binding]; other site 266835005460 Helix-turn-helix domains; Region: HTH; cl00088 266835005461 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266835005462 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 266835005463 Moco binding site; other site 266835005464 metal coordination site [ion binding]; other site 266835005465 dimerization interface [polypeptide binding]; other site 266835005466 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 266835005467 Helix-turn-helix domains; Region: HTH; cl00088 266835005468 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 266835005469 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 266835005470 ATP binding site [chemical binding]; other site 266835005471 active site 266835005472 substrate binding site [chemical binding]; other site 266835005473 choline dehydrogenase; Validated; Region: PRK02106 266835005474 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266835005475 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266835005476 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266835005477 active site pocket [active] 266835005478 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266835005479 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835005480 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 266835005481 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 266835005482 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835005483 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835005484 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266835005485 FAD binding domain; Region: FAD_binding_4; pfam01565 266835005486 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 266835005487 Protein of unknown function (DUF1344); Region: DUF1344; pfam07076 266835005488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 266835005489 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 266835005490 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 266835005491 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 266835005492 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 266835005493 putative active site [active] 266835005494 putative metal binding site [ion binding]; other site 266835005495 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 266835005496 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835005497 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 266835005498 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 266835005499 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 266835005500 excinuclease ABC subunit B; Provisional; Region: PRK05298 266835005501 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266835005502 ATP binding site [chemical binding]; other site 266835005503 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266835005504 nucleotide binding region [chemical binding]; other site 266835005505 ATP-binding site [chemical binding]; other site 266835005506 Ultra-violet resistance protein B; Region: UvrB; pfam12344 266835005507 UvrB/uvrC motif; Region: UVR; pfam02151 266835005508 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 266835005509 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 266835005510 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 266835005511 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 266835005512 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 266835005513 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266835005514 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835005515 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 266835005516 putative C-terminal domain interface [polypeptide binding]; other site 266835005517 putative GSH binding site (G-site) [chemical binding]; other site 266835005518 putative dimer interface [polypeptide binding]; other site 266835005519 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 266835005520 dimer interface [polypeptide binding]; other site 266835005521 N-terminal domain interface [polypeptide binding]; other site 266835005522 putative substrate binding pocket (H-site) [chemical binding]; other site 266835005523 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 266835005524 putative dimer interface [polypeptide binding]; other site 266835005525 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 266835005526 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 266835005527 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835005528 TPR motif; other site 266835005529 binding surface 266835005530 Tetratricopeptide repeat; Region: TPR_12; pfam13424 266835005531 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835005532 binding surface 266835005533 TPR motif; other site 266835005534 Tetratricopeptide repeat; Region: TPR_12; pfam13424 266835005535 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835005536 binding surface 266835005537 TPR motif; other site 266835005538 Sulfotransferase family; Region: Sulfotransfer_3; cl14559 266835005539 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 266835005540 DNA-binding site [nucleotide binding]; DNA binding site 266835005541 RNA-binding motif; other site 266835005542 Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; Region: KAZAL_FS; cl00097 266835005543 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 266835005544 DNA-binding site [nucleotide binding]; DNA binding site 266835005545 RNA-binding motif; other site 266835005546 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 266835005547 DNA-binding site [nucleotide binding]; DNA binding site 266835005548 RNA-binding motif; other site 266835005549 BA14K-like protein; Region: BA14K; pfam07886 266835005550 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266835005551 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 266835005552 homodimer interface [polypeptide binding]; other site 266835005553 substrate-cofactor binding pocket; other site 266835005554 catalytic residue [active] 266835005555 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266835005556 Helix-turn-helix domains; Region: HTH; cl00088 266835005557 osmolarity response regulator; Provisional; Region: ompR; PRK09468 266835005558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835005559 active site 266835005560 phosphorylation site [posttranslational modification] 266835005561 intermolecular recognition site; other site 266835005562 dimerization interface [polypeptide binding]; other site 266835005563 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835005564 DNA binding site [nucleotide binding] 266835005565 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266835005566 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266835005567 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 266835005568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835005569 ATP binding site [chemical binding]; other site 266835005570 Mg2+ binding site [ion binding]; other site 266835005571 G-X-G motif; other site 266835005572 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266835005573 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 266835005574 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 266835005575 dimer interface [polypeptide binding]; other site 266835005576 putative tRNA-binding site [nucleotide binding]; other site 266835005577 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 266835005578 Membrane fusogenic activity; Region: BMFP; cl01115 266835005579 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 266835005580 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 266835005581 Uncharacterized conserved protein [Function unknown]; Region: COG1565 266835005582 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 266835005583 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 266835005584 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 266835005585 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266835005586 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266835005587 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266835005588 active site 266835005589 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 266835005590 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 266835005591 Cupin domain; Region: Cupin_2; cl09118 266835005592 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266835005593 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835005594 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835005595 putative substrate translocation pore; other site 266835005596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266835005597 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835005598 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835005599 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266835005600 Helix-turn-helix domains; Region: HTH; cl00088 266835005601 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 266835005602 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 266835005603 5S rRNA interface [nucleotide binding]; other site 266835005604 CTC domain interface [polypeptide binding]; other site 266835005605 L16 interface [polypeptide binding]; other site 266835005606 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 266835005607 putative active site [active] 266835005608 catalytic residue [active] 266835005609 GTP-binding protein YchF; Reviewed; Region: PRK09601 266835005610 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 266835005611 G1 box; other site 266835005612 GTP/Mg2+ binding site [chemical binding]; other site 266835005613 Switch I region; other site 266835005614 G2 box; other site 266835005615 Switch II region; other site 266835005616 G3 box; other site 266835005617 G4 box; other site 266835005618 G5 box; other site 266835005619 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 266835005620 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: APH; cd05150 266835005621 active site 266835005622 ATP binding site [chemical binding]; other site 266835005623 Phosphotransferase enzyme family; Region: APH; pfam01636 266835005624 antibiotic binding site [chemical binding]; other site 266835005625 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 266835005626 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 266835005627 putative active site [active] 266835005628 putative catalytic site [active] 266835005629 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 266835005630 putative active site [active] 266835005631 putative catalytic site [active] 266835005632 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 266835005633 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266835005634 active site 266835005635 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266835005636 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 266835005637 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 266835005638 phosphate binding site [ion binding]; other site 266835005639 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 266835005640 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 266835005641 active site 266835005642 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 266835005643 cytochrome b; Provisional; Region: CYTB; MTH00119 266835005644 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 266835005645 Qi binding site; other site 266835005646 intrachain domain interface; other site 266835005647 interchain domain interface [polypeptide binding]; other site 266835005648 heme bH binding site [chemical binding]; other site 266835005649 heme bL binding site [chemical binding]; other site 266835005650 Qo binding site; other site 266835005651 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 266835005652 interchain domain interface [polypeptide binding]; other site 266835005653 intrachain domain interface; other site 266835005654 Qi binding site; other site 266835005655 Qo binding site; other site 266835005656 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 266835005657 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 266835005658 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 266835005659 [2Fe-2S] cluster binding site [ion binding]; other site 266835005660 Cupin domain; Region: Cupin_2; cl09118 266835005661 Epoxide hydrolase N terminus; Region: EHN; pfam06441 266835005662 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835005663 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835005664 Coenzyme A binding pocket [chemical binding]; other site 266835005665 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 266835005666 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266835005667 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 266835005668 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835005669 Walker A/P-loop; other site 266835005670 ATP binding site [chemical binding]; other site 266835005671 Q-loop/lid; other site 266835005672 ABC transporter signature motif; other site 266835005673 Walker B; other site 266835005674 D-loop; other site 266835005675 H-loop/switch region; other site 266835005676 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266835005677 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 266835005678 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 266835005679 Walker A/P-loop; other site 266835005680 ATP binding site [chemical binding]; other site 266835005681 Q-loop/lid; other site 266835005682 ABC transporter signature motif; other site 266835005683 Walker B; other site 266835005684 D-loop; other site 266835005685 H-loop/switch region; other site 266835005686 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 266835005687 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 266835005688 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 266835005689 DNA binding residues [nucleotide binding] 266835005690 dimer interface [polypeptide binding]; other site 266835005691 [2Fe-2S] cluster binding site [ion binding]; other site 266835005692 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 266835005693 Protein of unknown function (DUF1059); Region: DUF1059; cl02284 266835005694 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 266835005695 active site 266835005696 catalytic residues [active] 266835005697 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 266835005698 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 266835005699 active site 266835005700 NTP binding site [chemical binding]; other site 266835005701 metal binding triad [ion binding]; metal-binding site 266835005702 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 266835005703 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 266835005704 putative active site [active] 266835005705 putative CoA binding site [chemical binding]; other site 266835005706 nudix motif; other site 266835005707 metal binding site [ion binding]; metal-binding site 266835005708 Protein of unknown function (DUF1285); Region: DUF1285; cl01571 266835005709 MoxR-like ATPases [General function prediction only]; Region: COG0714 266835005710 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835005711 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 266835005712 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 266835005713 Aerotolerance regulator N-terminal; Region: BatA; cl06567 266835005714 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 266835005715 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 266835005716 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 266835005717 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 266835005718 osmolarity response regulator; Provisional; Region: ompR; PRK09468 266835005719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835005720 active site 266835005721 phosphorylation site [posttranslational modification] 266835005722 intermolecular recognition site; other site 266835005723 dimerization interface [polypeptide binding]; other site 266835005724 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835005725 DNA binding site [nucleotide binding] 266835005726 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266835005727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835005728 ATP binding site [chemical binding]; other site 266835005729 Mg2+ binding site [ion binding]; other site 266835005730 G-X-G motif; other site 266835005731 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 266835005732 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835005733 Walker A/P-loop; other site 266835005734 ATP binding site [chemical binding]; other site 266835005735 Q-loop/lid; other site 266835005736 ABC transporter signature motif; other site 266835005737 Walker B; other site 266835005738 D-loop; other site 266835005739 H-loop/switch region; other site 266835005740 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835005741 dimer interface [polypeptide binding]; other site 266835005742 conserved gate region; other site 266835005743 putative PBP binding loops; other site 266835005744 ABC-ATPase subunit interface; other site 266835005745 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 266835005746 NMT1-like family; Region: NMT1_2; cl15260 266835005747 Thymidine kinase; Region: TK; cl00631 266835005748 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 266835005749 EamA-like transporter family; Region: EamA; cl01037 266835005750 EamA-like transporter family; Region: EamA; cl01037 266835005751 Helix-turn-helix domains; Region: HTH; cl00088 266835005752 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835005753 dimerization interface [polypeptide binding]; other site 266835005754 Cytochrome c; Region: Cytochrom_C; cl11414 266835005755 hypothetical protein; Validated; Region: PRK09039 266835005756 Fic family protein [Function unknown]; Region: COG3177 266835005757 Fic/DOC family; Region: Fic; cl00960 266835005758 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 266835005759 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835005760 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; cl11978 266835005761 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 266835005762 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 266835005763 Potassium binding sites [ion binding]; other site 266835005764 Cesium cation binding sites [ion binding]; other site 266835005765 Isochorismatase family; Region: Isochorismatase; pfam00857 266835005766 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 266835005767 catalytic triad [active] 266835005768 conserved cis-peptide bond; other site 266835005769 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 266835005770 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 266835005771 conserved cys residue [active] 266835005772 maltose O-acetyltransferase; Provisional; Region: PRK10092 266835005773 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 266835005774 active site 266835005775 substrate binding site [chemical binding]; other site 266835005776 trimer interface [polypeptide binding]; other site 266835005777 CoA binding site [chemical binding]; other site 266835005778 Predicted membrane protein [Function unknown]; Region: COG3918 266835005779 mercuric reductase; Validated; Region: PRK06370 266835005780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835005781 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835005782 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266835005783 MFS transport protein AraJ; Provisional; Region: PRK10091 266835005784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835005785 putative substrate translocation pore; other site 266835005786 Predicted deacylase [General function prediction only]; Region: COG3608 266835005787 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 266835005788 active site 266835005789 Zn binding site [ion binding]; other site 266835005790 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266835005791 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 266835005792 tetramer interface [polypeptide binding]; other site 266835005793 active site 266835005794 Mg2+/Mn2+ binding site [ion binding]; other site 266835005795 anthranilate synthase; Provisional; Region: PRK13566 266835005796 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 266835005797 chorismate binding enzyme; Region: Chorismate_bind; cl10555 266835005798 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 266835005799 glutamine binding [chemical binding]; other site 266835005800 catalytic triad [active] 266835005801 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 266835005802 Cation efflux family; Region: Cation_efflux; cl00316 266835005803 DsrE/DsrF-like family; Region: DrsE; cl00672 266835005804 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266835005805 classical (c) SDRs; Region: SDR_c; cd05233 266835005806 NAD(P) binding site [chemical binding]; other site 266835005807 active site 266835005808 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 266835005809 Putative ammonia monooxygenase; Region: AmoA; pfam05145 266835005810 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 266835005811 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 266835005812 transcriptional regulator; Provisional; Region: PRK10632 266835005813 Helix-turn-helix domains; Region: HTH; cl00088 266835005814 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 266835005815 putative effector binding pocket; other site 266835005816 putative dimerization interface [polypeptide binding]; other site 266835005817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835005818 putative substrate translocation pore; other site 266835005819 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 266835005820 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266835005821 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835005822 Putative esterase; Region: Esterase; pfam00756 266835005823 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 266835005824 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 266835005825 2-isopropylmalate synthase; Validated; Region: PRK03739 266835005826 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 266835005827 active site 266835005828 catalytic residues [active] 266835005829 metal binding site [ion binding]; metal-binding site 266835005830 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 266835005831 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 266835005832 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835005833 TPR motif; other site 266835005834 binding surface 266835005835 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 266835005836 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 266835005837 nucleophilic elbow; other site 266835005838 catalytic triad; other site 266835005839 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266835005840 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 266835005841 putative active site [active] 266835005842 putative metal binding site [ion binding]; other site 266835005843 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266835005844 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 266835005845 nudix motif; other site 266835005846 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 266835005847 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 266835005848 putative dimer interface [polypeptide binding]; other site 266835005849 N-terminal domain interface [polypeptide binding]; other site 266835005850 putative substrate binding pocket (H-site) [chemical binding]; other site 266835005851 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835005852 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266835005853 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 266835005854 NAD binding site [chemical binding]; other site 266835005855 homotetramer interface [polypeptide binding]; other site 266835005856 homodimer interface [polypeptide binding]; other site 266835005857 active site 266835005858 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 266835005859 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 266835005860 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 266835005861 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835005862 dimerization interface [polypeptide binding]; other site 266835005863 putative DNA binding site [nucleotide binding]; other site 266835005864 putative Zn2+ binding site [ion binding]; other site 266835005865 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 266835005866 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 266835005867 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 266835005868 Protein of unknown function (DUF1134); Region: DUF1134; cl02235 266835005869 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385 266835005870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835005871 Response regulator receiver domain; Region: Response_reg; pfam00072 266835005872 active site 266835005873 phosphorylation site [posttranslational modification] 266835005874 intermolecular recognition site; other site 266835005875 dimerization interface [polypeptide binding]; other site 266835005876 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835005877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835005878 active site 266835005879 phosphorylation site [posttranslational modification] 266835005880 intermolecular recognition site; other site 266835005881 dimerization interface [polypeptide binding]; other site 266835005882 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835005883 DNA binding site [nucleotide binding] 266835005884 Helix-turn-helix domains; Region: HTH; cl00088 266835005885 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266835005886 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 266835005887 putative NAD(P) binding site [chemical binding]; other site 266835005888 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 266835005889 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 266835005890 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 266835005891 Ligand Binding Site [chemical binding]; other site 266835005892 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835005893 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835005894 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 266835005895 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266835005896 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266835005897 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266835005898 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835005899 Helix-turn-helix domains; Region: HTH; cl00088 266835005900 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 266835005901 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 266835005902 dimer interface [polypeptide binding]; other site 266835005903 active site 266835005904 short chain dehydrogenase; Provisional; Region: PRK06179 266835005905 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266835005906 NADP binding site [chemical binding]; other site 266835005907 active site 266835005908 steroid binding site; other site 266835005909 cyclase homology domain; Region: CHD; cd07302 266835005910 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 266835005911 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 266835005912 structural tetrad; other site 266835005913 FOG: WD40 repeat [General function prediction only]; Region: COG2319 266835005914 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 266835005915 structural tetrad; other site 266835005916 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 266835005917 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 266835005918 putative catalytic residues [active] 266835005919 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 266835005920 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 266835005921 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 266835005922 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 266835005923 Haemagglutinin; Region: HIM; pfam05662 266835005924 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835005925 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266835005926 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835005927 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266835005928 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835005929 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 266835005930 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 266835005931 putative active site [active] 266835005932 catalytic site [active] 266835005933 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 266835005934 putative active site [active] 266835005935 catalytic site [active] 266835005936 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 266835005937 putative catalytic site [active] 266835005938 putative metal binding site [ion binding]; other site 266835005939 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 266835005940 putative catalytic site [active] 266835005941 putative phosphate binding site [ion binding]; other site 266835005942 putative phosphate binding site [ion binding]; other site 266835005943 putative metal binding site [ion binding]; other site 266835005944 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 266835005945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835005946 active site 266835005947 phosphorylation site [posttranslational modification] 266835005948 intermolecular recognition site; other site 266835005949 dimerization interface [polypeptide binding]; other site 266835005950 ANTAR domain; Region: ANTAR; cl04297 266835005951 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266835005952 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 266835005953 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266835005954 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 266835005955 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266835005956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835005957 putative PBP binding loops; other site 266835005958 dimer interface [polypeptide binding]; other site 266835005959 ABC-ATPase subunit interface; other site 266835005960 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 266835005961 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 266835005962 Walker A/P-loop; other site 266835005963 ATP binding site [chemical binding]; other site 266835005964 Q-loop/lid; other site 266835005965 ABC transporter signature motif; other site 266835005966 Walker B; other site 266835005967 D-loop; other site 266835005968 H-loop/switch region; other site 266835005969 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 266835005970 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835005971 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 266835005972 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 266835005973 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 266835005974 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 266835005975 [2Fe-2S] cluster binding site [ion binding]; other site 266835005976 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 266835005977 [4Fe-4S] binding site [ion binding]; other site 266835005978 molybdopterin cofactor binding site; other site 266835005979 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 266835005980 molybdopterin cofactor binding site; other site 266835005981 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 266835005982 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 266835005983 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 266835005984 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835005985 tetrameric interface [polypeptide binding]; other site 266835005986 NAD binding site [chemical binding]; other site 266835005987 catalytic residues [active] 266835005988 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 266835005989 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835005990 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 266835005991 YCII-related domain; Region: YCII; cl00999 266835005992 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 266835005993 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266835005994 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 266835005995 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266835005996 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 266835005997 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 266835005998 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 266835005999 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 266835006000 Uncharacterized conserved protein [Function unknown]; Region: COG2308 266835006001 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 266835006002 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 266835006003 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 266835006004 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 266835006005 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 266835006006 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 266835006007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 266835006008 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 266835006009 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266835006010 FAD binding site [chemical binding]; other site 266835006011 substrate binding pocket [chemical binding]; other site 266835006012 catalytic base [active] 266835006013 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266835006014 Helix-turn-helix domains; Region: HTH; cl00088 266835006015 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 266835006016 dimerization interface [polypeptide binding]; other site 266835006017 substrate binding pocket [chemical binding]; other site 266835006018 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 266835006019 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 266835006020 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 266835006021 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 266835006022 RNA binding site [nucleotide binding]; other site 266835006023 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266835006024 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 266835006025 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266835006026 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 266835006027 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835006028 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835006029 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835006030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835006031 dimer interface [polypeptide binding]; other site 266835006032 conserved gate region; other site 266835006033 putative PBP binding loops; other site 266835006034 ABC-ATPase subunit interface; other site 266835006035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835006036 dimer interface [polypeptide binding]; other site 266835006037 conserved gate region; other site 266835006038 putative PBP binding loops; other site 266835006039 ABC-ATPase subunit interface; other site 266835006040 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835006041 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 266835006042 Walker A/P-loop; other site 266835006043 ATP binding site [chemical binding]; other site 266835006044 Q-loop/lid; other site 266835006045 ABC transporter signature motif; other site 266835006046 Walker B; other site 266835006047 D-loop; other site 266835006048 H-loop/switch region; other site 266835006049 TOBE domain; Region: TOBE_2; cl01440 266835006050 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 266835006051 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 266835006052 active site 266835006053 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835006054 Helix-turn-helix domains; Region: HTH; cl00088 266835006055 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 266835006056 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 266835006057 Protein of unknown function (DUF1625); Region: DUF1625; pfam07787 266835006058 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 266835006059 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835006060 DNA binding residues [nucleotide binding] 266835006061 dimerization interface [polypeptide binding]; other site 266835006062 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 266835006063 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835006064 DNA binding residues [nucleotide binding] 266835006065 dimerization interface [polypeptide binding]; other site 266835006066 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 266835006067 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 266835006068 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 266835006069 FliG C-terminal domain; Region: FliG_C; pfam01706 266835006070 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 266835006071 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 266835006072 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 266835006073 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 266835006074 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 266835006075 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 266835006076 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642 266835006077 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 266835006078 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 266835006079 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002 266835006080 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835006081 Walker A motif; other site 266835006082 ATP binding site [chemical binding]; other site 266835006083 Walker B motif; other site 266835006084 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003 266835006085 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 266835006086 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782 266835006087 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 266835006088 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 266835006089 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 266835006090 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 266835006091 SAF domain; Region: SAF; cl00555 266835006092 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 266835006093 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 266835006094 MgtE intracellular N domain; Region: MgtE_N; cl15244 266835006095 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 266835006096 Flagellar L-ring protein; Region: FlgH; cl00905 266835006097 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 266835006098 FliP family; Region: FliP; cl00593 266835006099 flagellin; Reviewed; Region: PRK12687 266835006100 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 266835006101 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 266835006102 flagellin; Reviewed; Region: PRK12687 266835006103 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 266835006104 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 266835006105 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 266835006106 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 266835006107 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 266835006108 flagellar motor protein MotB; Validated; Region: motB; PRK05996 266835006109 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266835006110 ligand binding site [chemical binding]; other site 266835006111 chemotaxis protein; Reviewed; Region: PRK12798 266835006112 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 266835006113 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 266835006114 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266835006115 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835006116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 266835006117 active site 266835006118 phosphorylation site [posttranslational modification] 266835006119 dimerization interface [polypeptide binding]; other site 266835006120 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835006121 DNA binding site [nucleotide binding] 266835006122 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 266835006123 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 266835006124 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 266835006125 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 266835006126 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 266835006127 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 266835006128 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 266835006129 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 266835006130 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 266835006131 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 266835006132 Flagellar protein FlaF; Region: FlaF; cl11454 266835006133 Flagellar protein FlbT; Region: FlbT; cl11455 266835006134 Flagellar hook capping protein; Region: FlgD; cl04347 266835006135 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 266835006136 Bacterial protein of unknown function (DUF894); Region: DUF894; pfam05977 266835006137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835006138 putative substrate translocation pore; other site 266835006139 Cupin domain; Region: Cupin_2; cl09118 266835006140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835006141 FAD dependent oxidoreductase; Region: DAO; pfam01266 266835006142 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835006143 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 266835006144 Walker A/P-loop; other site 266835006145 ATP binding site [chemical binding]; other site 266835006146 Q-loop/lid; other site 266835006147 ABC transporter signature motif; other site 266835006148 Walker B; other site 266835006149 D-loop; other site 266835006150 H-loop/switch region; other site 266835006151 TOBE domain; Region: TOBE_2; cl01440 266835006152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835006153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835006154 dimer interface [polypeptide binding]; other site 266835006155 conserved gate region; other site 266835006156 putative PBP binding loops; other site 266835006157 ABC-ATPase subunit interface; other site 266835006158 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835006159 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835006160 Cupin domain; Region: Cupin_2; cl09118 266835006161 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 266835006162 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 266835006163 Cl- selectivity filter; other site 266835006164 Cl- binding residues [ion binding]; other site 266835006165 pore gating glutamate residue; other site 266835006166 dimer interface [polypeptide binding]; other site 266835006167 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 266835006168 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 266835006169 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 266835006170 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 266835006171 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 266835006172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835006173 S-adenosylmethionine binding site [chemical binding]; other site 266835006174 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266835006175 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835006176 Predicted aminopeptidase [General function prediction only]; Region: COG4324 266835006177 Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023 266835006178 Rod binding protein; Region: Rod-binding; cl01626 266835006179 SCP-2 sterol transfer family; Region: SCP2; cl01225 266835006180 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835006181 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 266835006182 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 266835006183 active site 266835006184 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266835006185 dimer interface [polypeptide binding]; other site 266835006186 catalytic residues [active] 266835006187 substrate binding site [chemical binding]; other site 266835006188 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 266835006189 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 266835006190 Protein of unknown function (DUF1007); Region: DUF1007; cl01487 266835006191 High-affinity nickel-transport protein; Region: NicO; cl00964 266835006192 High-affinity nickel-transport protein; Region: NicO; cl00964 266835006193 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835006194 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 266835006195 putative NAD(P) binding site [chemical binding]; other site 266835006196 active site 266835006197 putative substrate binding site [chemical binding]; other site 266835006198 Cation efflux family; Region: Cation_efflux; cl00316 266835006199 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 266835006200 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 266835006201 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835006202 aspartate aminotransferase; Provisional; Region: PRK05764 266835006203 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835006204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835006205 homodimer interface [polypeptide binding]; other site 266835006206 catalytic residue [active] 266835006207 YCII-related domain; Region: YCII; cl00999 266835006208 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 266835006209 classical (c) SDRs; Region: SDR_c; cd05233 266835006210 NAD(P) binding site [chemical binding]; other site 266835006211 active site 266835006212 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 266835006213 putative metal binding site [ion binding]; other site 266835006214 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 266835006215 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 266835006216 active site residue [active] 266835006217 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 266835006218 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 266835006219 active site 266835006220 intersubunit interface [polypeptide binding]; other site 266835006221 catalytic residue [active] 266835006222 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835006223 short chain dehydrogenase; Provisional; Region: PRK12828 266835006224 NAD(P) binding site [chemical binding]; other site 266835006225 active site 266835006226 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 266835006227 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266835006228 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835006229 Peptidase M15; Region: Peptidase_M15_3; cl01194 266835006230 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 266835006231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835006232 active site 266835006233 phosphorylation site [posttranslational modification] 266835006234 intermolecular recognition site; other site 266835006235 dimerization interface [polypeptide binding]; other site 266835006236 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835006237 Walker A motif; other site 266835006238 ATP binding site [chemical binding]; other site 266835006239 Walker B motif; other site 266835006240 arginine finger; other site 266835006241 Helix-turn-helix domains; Region: HTH; cl00088 266835006242 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 266835006243 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 266835006244 active site 266835006245 Zn binding site [ion binding]; other site 266835006246 Uncharacterized conserved protein [Function unknown]; Region: COG3743 266835006247 aminodeoxychorismate synthase; Provisional; Region: PRK07508 266835006248 chorismate binding enzyme; Region: Chorismate_bind; cl10555 266835006249 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 266835006250 substrate-cofactor binding pocket; other site 266835006251 homodimer interface [polypeptide binding]; other site 266835006252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835006253 catalytic residue [active] 266835006254 YCII-related domain; Region: YCII; cl00999 266835006255 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 266835006256 Helix-turn-helix domains; Region: HTH; cl00088 266835006257 transcriptional activator TtdR; Provisional; Region: PRK09801 266835006258 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266835006259 putative effector binding pocket; other site 266835006260 dimerization interface [polypeptide binding]; other site 266835006261 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266835006262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835006263 NAD(P) binding site [chemical binding]; other site 266835006264 active site 266835006265 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 266835006266 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 266835006267 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 266835006268 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 266835006269 active site 266835006270 metal binding site [ion binding]; metal-binding site 266835006271 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 266835006272 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 266835006273 putative peptidoglycan binding site; other site 266835006274 ferrochelatase; Reviewed; Region: hemH; PRK00035 266835006275 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 266835006276 C-terminal domain interface [polypeptide binding]; other site 266835006277 active site 266835006278 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 266835006279 active site 266835006280 N-terminal domain interface [polypeptide binding]; other site 266835006281 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835006282 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835006283 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 266835006284 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 266835006285 KpsF/GutQ family protein; Region: kpsF; TIGR00393 266835006286 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 266835006287 putative active site [active] 266835006288 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 266835006289 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; cl12051 266835006290 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 266835006291 active site 266835006292 tetramer interface; other site 266835006293 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 266835006294 lytic murein transglycosylase; Region: MltB_2; TIGR02283 266835006295 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 266835006296 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 266835006297 active site 266835006298 catalytic triad [active] 266835006299 oxyanion hole [active] 266835006300 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 266835006301 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835006302 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 266835006303 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 266835006304 active site 266835006305 dimer interface [polypeptide binding]; other site 266835006306 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 266835006307 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 266835006308 active site 266835006309 FMN binding site [chemical binding]; other site 266835006310 substrate binding site [chemical binding]; other site 266835006311 3Fe-4S cluster binding site [ion binding]; other site 266835006312 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 266835006313 domain interface; other site 266835006314 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 266835006315 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 266835006316 tetramer interface [polypeptide binding]; other site 266835006317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835006318 catalytic residue [active] 266835006319 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266835006320 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 266835006321 putative dimer interface [polypeptide binding]; other site 266835006322 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 266835006323 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835006324 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835006325 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 266835006326 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266835006327 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835006328 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 266835006329 active site 266835006330 N-formylglutamate amidohydrolase; Region: FGase; cl01522 266835006331 Response regulator receiver domain; Region: Response_reg; pfam00072 266835006332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835006333 active site 266835006334 phosphorylation site [posttranslational modification] 266835006335 intermolecular recognition site; other site 266835006336 dimerization interface [polypeptide binding]; other site 266835006337 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 266835006338 Protein of unknown function (DUF993); Region: DUF993; pfam06187 266835006339 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266835006340 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835006341 DNA binding site [nucleotide binding] 266835006342 domain linker motif; other site 266835006343 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 266835006344 putative dimerization interface [polypeptide binding]; other site 266835006345 putative ligand binding site [chemical binding]; other site 266835006346 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835006347 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835006348 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 266835006349 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 266835006350 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 266835006351 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 266835006352 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266835006353 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835006354 substrate binding site [chemical binding]; other site 266835006355 oxyanion hole (OAH) forming residues; other site 266835006356 trimer interface [polypeptide binding]; other site 266835006357 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835006358 Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118 266835006359 NAD(P) binding site [chemical binding]; other site 266835006360 catalytic residues [active] 266835006361 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835006362 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835006363 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835006364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835006365 putative PBP binding loops; other site 266835006366 dimer interface [polypeptide binding]; other site 266835006367 ABC-ATPase subunit interface; other site 266835006368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835006369 dimer interface [polypeptide binding]; other site 266835006370 conserved gate region; other site 266835006371 putative PBP binding loops; other site 266835006372 ABC-ATPase subunit interface; other site 266835006373 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266835006374 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 266835006375 Walker A/P-loop; other site 266835006376 ATP binding site [chemical binding]; other site 266835006377 Q-loop/lid; other site 266835006378 ABC transporter signature motif; other site 266835006379 Walker B; other site 266835006380 D-loop; other site 266835006381 H-loop/switch region; other site 266835006382 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 266835006383 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266835006384 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266835006385 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835006386 NAD(P) binding site [chemical binding]; other site 266835006387 active site 266835006388 choline dehydrogenase; Validated; Region: PRK02106 266835006389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835006390 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266835006391 Stress responsive A/B Barrel Domain; Region: Dabb; cl06768 266835006392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835006393 putative substrate translocation pore; other site 266835006394 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 266835006395 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 266835006396 putative catalytic site [active] 266835006397 putative metal binding site [ion binding]; other site 266835006398 putative phosphate binding site [ion binding]; other site 266835006399 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 266835006400 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 266835006401 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835006402 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835006403 Walker A/P-loop; other site 266835006404 ATP binding site [chemical binding]; other site 266835006405 Q-loop/lid; other site 266835006406 ABC transporter signature motif; other site 266835006407 Walker B; other site 266835006408 D-loop; other site 266835006409 H-loop/switch region; other site 266835006410 TOBE domain; Region: TOBE_2; cl01440 266835006411 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835006412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835006413 dimer interface [polypeptide binding]; other site 266835006414 conserved gate region; other site 266835006415 putative PBP binding loops; other site 266835006416 ABC-ATPase subunit interface; other site 266835006417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835006418 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835006419 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835006420 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835006421 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 266835006422 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 266835006423 putative active site [active] 266835006424 metal binding site [ion binding]; metal-binding site 266835006425 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835006426 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 266835006427 NAD(P) binding site [chemical binding]; other site 266835006428 catalytic residues [active] 266835006429 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 266835006430 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 266835006431 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266835006432 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 266835006433 Spore germination protein; Region: Spore_permease; cl15802 266835006434 N-formylglutamate amidohydrolase; Region: FGase; cl01522 266835006435 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266835006436 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266835006437 putative active site [active] 266835006438 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 266835006439 classical (c) SDRs; Region: SDR_c; cd05233 266835006440 NAD(P) binding site [chemical binding]; other site 266835006441 active site 266835006442 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835006443 Helix-turn-helix domains; Region: HTH; cl00088 266835006444 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 266835006445 putative effector binding pocket; other site 266835006446 putative dimerization interface [polypeptide binding]; other site 266835006447 GtrA-like protein; Region: GtrA; cl00971 266835006448 YdjC-like protein; Region: YdjC; cl01344 266835006449 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 266835006450 Ligand binding site; other site 266835006451 Putative Catalytic site; other site 266835006452 DXD motif; other site 266835006453 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266835006454 2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291 266835006455 NADP binding site [chemical binding]; other site 266835006456 dimer interface [polypeptide binding]; other site 266835006457 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266835006458 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 266835006459 FAD binding site [chemical binding]; other site 266835006460 substrate binding site [chemical binding]; other site 266835006461 catalytic base [active] 266835006462 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 266835006463 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835006464 NAD(P) binding site [chemical binding]; other site 266835006465 active site 266835006466 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 266835006467 putative active site [active] 266835006468 putative catalytic site [active] 266835006469 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 266835006470 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 266835006471 putative active site [active] 266835006472 putative substrate binding site [chemical binding]; other site 266835006473 ATP binding site [chemical binding]; other site 266835006474 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 266835006475 classical (c) SDRs; Region: SDR_c; cd05233 266835006476 NAD(P) binding site [chemical binding]; other site 266835006477 active site 266835006478 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835006479 Helix-turn-helix domains; Region: HTH; cl00088 266835006480 Protein of unknown function (DUF680); Region: DUF680; pfam05079 266835006481 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835006482 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835006483 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 266835006484 Type 1 glutamine amidotransferase (GATase1)-like domain found in Sinorhizobium meliloti Rm1021 ThuA (SmThuA); Region: GATase1_ThuA; cd03142 266835006485 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 266835006486 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 266835006487 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 266835006488 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835006489 Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767 266835006490 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835006491 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835006492 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266835006493 classical (c) SDRs; Region: SDR_c; cd05233 266835006494 NAD(P) binding site [chemical binding]; other site 266835006495 active site 266835006496 SET domain; Region: SET; cl02566 266835006497 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 266835006498 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835006499 binding surface 266835006500 TPR motif; other site 266835006501 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835006502 binding surface 266835006503 TPR motif; other site 266835006504 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 266835006505 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835006506 binding surface 266835006507 TPR motif; other site 266835006508 Protein of unknown function (DUF992); Region: DUF992; pfam06186 266835006509 Protein of unknown function (DUF992); Region: DUF992; pfam06186 266835006510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835006511 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835006512 putative substrate translocation pore; other site 266835006513 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835006514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835006515 active site 266835006516 phosphorylation site [posttranslational modification] 266835006517 intermolecular recognition site; other site 266835006518 dimerization interface [polypeptide binding]; other site 266835006519 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835006520 DNA binding site [nucleotide binding] 266835006521 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 266835006522 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 266835006523 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 266835006524 Ligand Binding Site [chemical binding]; other site 266835006525 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835006526 dimer interface [polypeptide binding]; other site 266835006527 phosphorylation site [posttranslational modification] 266835006528 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835006529 ATP binding site [chemical binding]; other site 266835006530 Mg2+ binding site [ion binding]; other site 266835006531 G-X-G motif; other site 266835006532 K+-transporting ATPase, c chain; Region: KdpC; cl00944 266835006533 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 266835006534 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266835006535 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266835006536 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 266835006537 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 266835006538 dimerization interface [polypeptide binding]; other site 266835006539 metal binding site [ion binding]; metal-binding site 266835006540 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266835006541 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266835006542 ligand binding site [chemical binding]; other site 266835006543 flexible hinge region; other site 266835006544 Helix-turn-helix domains; Region: HTH; cl00088 266835006545 Protein of unknown function (DUF982); Region: DUF982; pfam06169 266835006546 OpgC protein; Region: OpgC_C; cl00792 266835006547 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 266835006548 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 266835006549 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 266835006550 ligand binding site [chemical binding]; other site 266835006551 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835006552 Anti-sigma-K factor rskA; Region: RskA; cl15366 266835006553 SlyX; Region: SlyX; cl01090 266835006554 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 266835006555 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835006556 Walker A/P-loop; other site 266835006557 ATP binding site [chemical binding]; other site 266835006558 Q-loop/lid; other site 266835006559 ABC transporter signature motif; other site 266835006560 Walker B; other site 266835006561 D-loop; other site 266835006562 H-loop/switch region; other site 266835006563 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 266835006564 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266835006565 TM-ABC transporter signature motif; other site 266835006566 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266835006567 TM-ABC transporter signature motif; other site 266835006568 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 266835006569 active site 266835006570 catalytic motif [active] 266835006571 Zn binding site [ion binding]; other site 266835006572 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 266835006573 thymidine phosphorylase; Region: T_phosphoryl; TIGR02643 266835006574 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 266835006575 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 266835006576 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 266835006577 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 266835006578 catalytic motif [active] 266835006579 Catalytic residue [active] 266835006580 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 266835006581 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 266835006582 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 266835006583 active site 266835006584 purine riboside binding site [chemical binding]; other site 266835006585 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 266835006586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835006587 S-adenosylmethionine binding site [chemical binding]; other site 266835006588 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 266835006589 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266835006590 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266835006591 ATP binding site [chemical binding]; other site 266835006592 bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional; Region: PRK13982 266835006593 Flavoprotein; Region: Flavoprotein; cl08021 266835006594 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 266835006595 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 266835006596 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 266835006597 nudix motif; other site 266835006598 PAS fold; Region: PAS_4; pfam08448 266835006599 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835006600 metal binding site [ion binding]; metal-binding site 266835006601 active site 266835006602 I-site; other site 266835006603 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835006604 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 266835006605 Protein of unknown function (DUF419); Region: DUF419; cl15265 266835006606 Predicted membrane protein (DUF2214); Region: DUF2214; cl01427 266835006607 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 266835006608 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 266835006609 minor groove reading motif; other site 266835006610 helix-hairpin-helix signature motif; other site 266835006611 substrate binding pocket [chemical binding]; other site 266835006612 active site 266835006613 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 266835006614 Integral membrane protein (DUF2244); Region: DUF2244; cl02302 266835006615 Leucine carboxyl methyltransferase; Region: LCM; cl01306 266835006616 Helix-turn-helix domain; Region: HTH_18; pfam12833 266835006617 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 266835006618 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 266835006619 DNA binding site [nucleotide binding] 266835006620 active site 266835006621 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266835006622 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 266835006623 substrate binding site [chemical binding]; other site 266835006624 dimer interface [polypeptide binding]; other site 266835006625 ATP binding site [chemical binding]; other site 266835006626 amidase; Provisional; Region: PRK07486 266835006627 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 266835006628 LysE type translocator; Region: LysE; cl00565 266835006629 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 266835006630 active site 266835006631 tetramer interface [polypeptide binding]; other site 266835006632 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 266835006633 putative dimer interface [polypeptide binding]; other site 266835006634 Protein of unknown function (DUF1150); Region: DUF1150; cl11577 266835006635 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 266835006636 active site 266835006637 phosphorylation site [posttranslational modification] 266835006638 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 266835006639 30S subunit binding site; other site 266835006640 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 266835006641 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 266835006642 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 266835006643 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 266835006644 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 266835006645 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 266835006646 Walker A/P-loop; other site 266835006647 ATP binding site [chemical binding]; other site 266835006648 Q-loop/lid; other site 266835006649 ABC transporter signature motif; other site 266835006650 Walker B; other site 266835006651 D-loop; other site 266835006652 H-loop/switch region; other site 266835006653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 266835006654 OstA-like protein; Region: OstA; cl00844 266835006655 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 266835006656 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 266835006657 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 266835006658 tandem repeat interface [polypeptide binding]; other site 266835006659 oligomer interface [polypeptide binding]; other site 266835006660 active site residues [active] 266835006661 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 266835006662 IHF dimer interface [polypeptide binding]; other site 266835006663 IHF - DNA interface [nucleotide binding]; other site 266835006664 ornithine cyclodeaminase; Validated; Region: PRK06141 266835006665 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835006666 EVE domain; Region: EVE; cl00728 266835006667 EVE domain; Region: EVE; cl00728 266835006668 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835006669 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 266835006670 putative dimer interface [polypeptide binding]; other site 266835006671 Helix-turn-helix domains; Region: HTH; cl00088 266835006672 WYL domain; Region: WYL; cl14852 266835006673 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 266835006674 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835006675 S-adenosylmethionine binding site [chemical binding]; other site 266835006676 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 266835006677 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 266835006678 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 266835006679 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 266835006680 lipoprotein signal peptidase; Provisional; Region: PRK14787 266835006681 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 266835006682 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 266835006683 NADP binding site [chemical binding]; other site 266835006684 dimer interface [polypeptide binding]; other site 266835006685 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 266835006686 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 266835006687 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835006688 dimer interface [polypeptide binding]; other site 266835006689 phosphorylation site [posttranslational modification] 266835006690 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835006691 ATP binding site [chemical binding]; other site 266835006692 Mg2+ binding site [ion binding]; other site 266835006693 G-X-G motif; other site 266835006694 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835006695 Response regulator receiver domain; Region: Response_reg; pfam00072 266835006696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835006697 active site 266835006698 phosphorylation site [posttranslational modification] 266835006699 intermolecular recognition site; other site 266835006700 dimerization interface [polypeptide binding]; other site 266835006701 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835006702 Protein of unknown function (DUF419); Region: DUF419; cl15265 266835006703 Predicted membrane protein [Function unknown]; Region: COG2860 266835006704 UPF0126 domain; Region: UPF0126; pfam03458 266835006705 UPF0126 domain; Region: UPF0126; pfam03458 266835006706 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 266835006707 dimer interface [polypeptide binding]; other site 266835006708 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 266835006709 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 266835006710 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 266835006711 putative di-iron ligands [ion binding]; other site 266835006712 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 266835006713 conserved cys residue [active] 266835006714 choline dehydrogenase; Validated; Region: PRK02106 266835006715 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266835006716 Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526 266835006717 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 266835006718 Active Sites [active] 266835006719 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 266835006720 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 266835006721 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 266835006722 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 266835006723 siroheme synthase; Provisional; Region: cysG; PRK10637 266835006724 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 266835006725 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 266835006726 Protein required for attachment to host cells; Region: Host_attach; cl02398 266835006727 putative cation:proton antiport protein; Provisional; Region: PRK10669 266835006728 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 266835006729 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835006730 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266835006731 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR4; cd08270 266835006732 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266835006733 putative NAD(P) binding site [chemical binding]; other site 266835006734 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266835006735 classical (c) SDRs; Region: SDR_c; cd05233 266835006736 NAD(P) binding site [chemical binding]; other site 266835006737 active site 266835006738 Transglycosylase; Region: Transgly; cl07896 266835006739 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 266835006740 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 266835006741 Ion channel; Region: Ion_trans_2; cl11596 266835006742 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266835006743 ligand binding site [chemical binding]; other site 266835006744 flexible hinge region; other site 266835006745 Heme NO binding associated; Region: HNOBA; pfam07701 266835006746 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 266835006747 cyclase homology domain; Region: CHD; cd07302 266835006748 nucleotidyl binding site; other site 266835006749 metal binding site [ion binding]; metal-binding site 266835006750 dimer interface [polypeptide binding]; other site 266835006751 Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154 266835006752 Rab subfamily motif 1 (RabSF1); other site 266835006753 G1 box; other site 266835006754 GTP/Mg2+ binding site [chemical binding]; other site 266835006755 Rab subfamily motif 2 (RabSF2); other site 266835006756 Switch I region; other site 266835006757 G2 box; other site 266835006758 effector interaction site; other site 266835006759 GDI interaction site; other site 266835006760 Rab family motif 1 (RabF1); other site 266835006761 GEF interaction site [polypeptide binding]; other site 266835006762 Rab family motif 2 (RabF2); other site 266835006763 G3 box; other site 266835006764 Switch II region; other site 266835006765 Rab family motif 3 (RabF3); other site 266835006766 Rab family motif 4 (RabF4); other site 266835006767 Rab family motif 5 (RabF5); other site 266835006768 Rab subfamily motif 3 (RabSF3); other site 266835006769 G4 box; other site 266835006770 G5 box; other site 266835006771 Rab subfamily motif 4 (RabSF4); other site 266835006772 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266835006773 ligand binding site [chemical binding]; other site 266835006774 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 266835006775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835006776 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 266835006777 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266835006778 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 266835006779 putative ADP-binding pocket [chemical binding]; other site 266835006780 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266835006781 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 266835006782 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266835006783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835006784 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 266835006785 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 266835006786 Walker A/P-loop; other site 266835006787 ATP binding site [chemical binding]; other site 266835006788 Q-loop/lid; other site 266835006789 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835006790 ABC transporter signature motif; other site 266835006791 Walker B; other site 266835006792 D-loop; other site 266835006793 H-loop/switch region; other site 266835006794 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266835006795 ligand binding site [chemical binding]; other site 266835006796 flexible hinge region; other site 266835006797 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266835006798 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928 266835006799 NodB motif; other site 266835006800 putative active site [active] 266835006801 putative catalytic site [active] 266835006802 putative Zn binding site [ion binding]; other site 266835006803 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266835006804 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266835006805 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 266835006806 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 266835006807 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835006808 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 266835006809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835006810 cyclase homology domain; Region: CHD; cd07302 266835006811 nucleotidyl binding site; other site 266835006812 metal binding site [ion binding]; metal-binding site 266835006813 dimer interface [polypeptide binding]; other site 266835006814 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266835006815 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835006816 Walker A/P-loop; other site 266835006817 ATP binding site [chemical binding]; other site 266835006818 Q-loop/lid; other site 266835006819 ABC transporter signature motif; other site 266835006820 Walker B; other site 266835006821 D-loop; other site 266835006822 H-loop/switch region; other site 266835006823 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835006824 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835006825 Walker A/P-loop; other site 266835006826 ATP binding site [chemical binding]; other site 266835006827 Q-loop/lid; other site 266835006828 ABC transporter signature motif; other site 266835006829 Walker B; other site 266835006830 D-loop; other site 266835006831 H-loop/switch region; other site 266835006832 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835006833 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 266835006834 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 266835006835 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835006836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835006837 dimer interface [polypeptide binding]; other site 266835006838 conserved gate region; other site 266835006839 putative PBP binding loops; other site 266835006840 ABC-ATPase subunit interface; other site 266835006841 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 266835006842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835006843 dimer interface [polypeptide binding]; other site 266835006844 conserved gate region; other site 266835006845 putative PBP binding loops; other site 266835006846 ABC-ATPase subunit interface; other site 266835006847 S-adenosyl-L-methionine methyltransferase; Region: Methyltransf_17; pfam12692 266835006848 cyclase homology domain; Region: CHD; cd07302 266835006849 nucleotidyl binding site; other site 266835006850 metal binding site [ion binding]; metal-binding site 266835006851 dimer interface [polypeptide binding]; other site 266835006852 putative acetyltransferase YhhY; Provisional; Region: PRK10140 266835006853 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835006854 Coenzyme A binding pocket [chemical binding]; other site 266835006855 cyclase homology domain; Region: CHD; cd07302 266835006856 nucleotidyl binding site; other site 266835006857 metal binding site [ion binding]; metal-binding site 266835006858 dimer interface [polypeptide binding]; other site 266835006859 TolB amino-terminal domain; Region: TolB_N; cl00639 266835006860 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835006861 TPR motif; other site 266835006862 binding surface 266835006863 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835006864 TPR motif; other site 266835006865 binding surface 266835006866 Double zinc ribbon; Region: DZR; pfam12773 266835006867 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 266835006868 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 266835006869 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 266835006870 cyclase homology domain; Region: CHD; cd07302 266835006871 nucleotidyl binding site; other site 266835006872 metal binding site [ion binding]; metal-binding site 266835006873 dimer interface [polypeptide binding]; other site 266835006874 Predicted ATPase [General function prediction only]; Region: COG3899 266835006875 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835006876 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 266835006877 putative catalytic residues [active] 266835006878 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 266835006879 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 266835006880 active site 266835006881 Nodulation protein S (NodS); Region: NodS; pfam05401 266835006882 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 266835006883 putative active site [active] 266835006884 putative metal binding site [ion binding]; other site 266835006885 Integrase core domain; Region: rve; cl01316 266835006886 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266835006887 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266835006888 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266835006889 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 266835006890 Mlo family; Region: Mlo; pfam03094 266835006891 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266835006892 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266835006893 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 266835006894 putative active site [active] 266835006895 catalytic site [active] 266835006896 putative substrate binding site [chemical binding]; other site 266835006897 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 266835006898 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 266835006899 metal binding site [ion binding]; metal-binding site 266835006900 putative dimer interface [polypeptide binding]; other site 266835006901 5'-3' exonuclease; Region: 53EXOc; smart00475 266835006902 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 266835006903 active site 266835006904 metal binding site 1 [ion binding]; metal-binding site 266835006905 putative 5' ssDNA interaction site; other site 266835006906 metal binding site 3; metal-binding site 266835006907 metal binding site 2 [ion binding]; metal-binding site 266835006908 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 266835006909 putative DNA binding site [nucleotide binding]; other site 266835006910 putative metal binding site [ion binding]; other site 266835006911 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 266835006912 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 266835006913 active site 266835006914 catalytic site [active] 266835006915 substrate binding site [chemical binding]; other site 266835006916 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 266835006917 active site 266835006918 DNA binding site [nucleotide binding] 266835006919 catalytic site [active] 266835006920 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 266835006921 metal binding site 2 [ion binding]; metal-binding site 266835006922 putative DNA binding helix; other site 266835006923 metal binding site 1 [ion binding]; metal-binding site 266835006924 dimer interface [polypeptide binding]; other site 266835006925 structural Zn2+ binding site [ion binding]; other site 266835006926 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 266835006927 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 266835006928 structural tetrad; other site 266835006929 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 266835006930 structural tetrad; other site 266835006931 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 266835006932 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 266835006933 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 266835006934 putative ligand binding pocket/active site [active] 266835006935 putative metal binding site [ion binding]; other site 266835006936 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 266835006937 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 266835006938 putative active site [active] 266835006939 putative metal binding site [ion binding]; other site 266835006940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 266835006941 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 266835006942 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 266835006943 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 266835006944 cleavage site 266835006945 active site 266835006946 substrate binding sites [chemical binding]; other site 266835006947 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 266835006948 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835006949 active site 266835006950 catalytic tetrad [active] 266835006951 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835006952 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835006953 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266835006954 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266835006955 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 266835006956 Walker A/P-loop; other site 266835006957 ATP binding site [chemical binding]; other site 266835006958 Q-loop/lid; other site 266835006959 ABC transporter signature motif; other site 266835006960 Walker B; other site 266835006961 D-loop; other site 266835006962 H-loop/switch region; other site 266835006963 TOBE domain; Region: TOBE_2; cl01440 266835006964 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835006965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835006966 dimer interface [polypeptide binding]; other site 266835006967 conserved gate region; other site 266835006968 putative PBP binding loops; other site 266835006969 ABC-ATPase subunit interface; other site 266835006970 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 266835006971 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835006972 dimer interface [polypeptide binding]; other site 266835006973 conserved gate region; other site 266835006974 putative PBP binding loops; other site 266835006975 ABC-ATPase subunit interface; other site 266835006976 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835006977 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266835006978 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835006979 DNA binding site [nucleotide binding] 266835006980 domain linker motif; other site 266835006981 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 266835006982 ligand binding site [chemical binding]; other site 266835006983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835006984 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 266835006985 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 266835006986 Bacterial Ig-like domain; Region: Big_5; cl01012 266835006987 Copper resistance protein D; Region: CopD; cl00563 266835006988 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 266835006989 Protein of unknown function (DUF461); Region: DUF461; cl01071 266835006990 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835006991 Helix-turn-helix domains; Region: HTH; cl00088 266835006992 DNA-binding site [nucleotide binding]; DNA binding site 266835006993 FCD domain; Region: FCD; cl11656 266835006994 SAF domain; Region: SAF; cl00555 266835006995 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 266835006996 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 266835006997 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 266835006998 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835006999 active site 266835007000 catalytic tetrad [active] 266835007001 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266835007002 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 266835007003 putative ligand binding site [chemical binding]; other site 266835007004 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835007005 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 266835007006 Walker A/P-loop; other site 266835007007 ATP binding site [chemical binding]; other site 266835007008 Q-loop/lid; other site 266835007009 ABC transporter signature motif; other site 266835007010 Walker B; other site 266835007011 D-loop; other site 266835007012 H-loop/switch region; other site 266835007013 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 266835007014 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835007015 TM-ABC transporter signature motif; other site 266835007016 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 266835007017 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 266835007018 putative NAD(P) binding site [chemical binding]; other site 266835007019 catalytic Zn binding site [ion binding]; other site 266835007020 structural Zn binding site [ion binding]; other site 266835007021 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 266835007022 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835007023 DNA-binding site [nucleotide binding]; DNA binding site 266835007024 UTRA domain; Region: UTRA; cl01230 266835007025 Phosphonate metabolism protein PhnG; Region: PhnG; cl01454 266835007026 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; cl01455 266835007027 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; cl01456 266835007028 FosX, a fosfomycin resistance protein, catalyzes the addition of a water molecule to the C1 position of the antibiotic with inversion of configuration at C1; Region: FosX; cd08364 266835007029 dimer interface [polypeptide binding]; other site 266835007030 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835007031 active site 266835007032 Mn binding site [ion binding]; other site 266835007033 Phosphonate metabolism protein PhnJ; Region: PhnJ; cl01457 266835007034 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 266835007035 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835007036 Walker A/P-loop; other site 266835007037 ATP binding site [chemical binding]; other site 266835007038 Q-loop/lid; other site 266835007039 ABC transporter signature motif; other site 266835007040 Walker B; other site 266835007041 D-loop; other site 266835007042 H-loop/switch region; other site 266835007043 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835007044 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 266835007045 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835007046 Walker A/P-loop; other site 266835007047 ATP binding site [chemical binding]; other site 266835007048 Q-loop/lid; other site 266835007049 ABC transporter signature motif; other site 266835007050 Walker B; other site 266835007051 D-loop; other site 266835007052 H-loop/switch region; other site 266835007053 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 266835007054 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 266835007055 trimer interface [polypeptide binding]; other site 266835007056 active site 266835007057 substrate binding site [chemical binding]; other site 266835007058 CoA binding site [chemical binding]; other site 266835007059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255 266835007060 Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975 266835007061 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 266835007062 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 266835007063 Walker A/P-loop; other site 266835007064 ATP binding site [chemical binding]; other site 266835007065 Q-loop/lid; other site 266835007066 ABC transporter signature motif; other site 266835007067 Walker B; other site 266835007068 D-loop; other site 266835007069 H-loop/switch region; other site 266835007070 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 266835007071 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 266835007072 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 266835007073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835007074 dimer interface [polypeptide binding]; other site 266835007075 conserved gate region; other site 266835007076 ABC-ATPase subunit interface; other site 266835007077 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 266835007078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835007079 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266835007080 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 266835007081 DNA interaction; other site 266835007082 Metal-binding active site; metal-binding site 266835007083 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835007084 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835007085 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 266835007086 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266835007087 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 266835007088 AP (apurinic/apyrimidinic) site pocket; other site 266835007089 DNA interaction; other site 266835007090 Metal-binding active site; metal-binding site 266835007091 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 266835007092 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266835007093 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 266835007094 AP (apurinic/apyrimidinic) site pocket; other site 266835007095 DNA interaction; other site 266835007096 Metal-binding active site; metal-binding site 266835007097 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266835007098 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266835007099 active site pocket [active] 266835007100 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266835007101 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835007102 DNA-binding site [nucleotide binding]; DNA binding site 266835007103 FCD domain; Region: FCD; cl11656 266835007104 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266835007105 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835007106 amidase; Provisional; Region: PRK07056 266835007107 Amidase; Region: Amidase; cl11426 266835007108 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 266835007109 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 266835007110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835007111 NAD(P) binding site [chemical binding]; other site 266835007112 active site 266835007113 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835007114 Helix-turn-helix domains; Region: HTH; cl00088 266835007115 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266835007116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 266835007117 Cupin domain; Region: Cupin_2; cl09118 266835007118 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266835007119 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835007120 Cupin domain; Region: Cupin_2; cl09118 266835007121 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835007122 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266835007123 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835007124 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835007125 ABC transporter signature motif; other site 266835007126 Walker B; other site 266835007127 D-loop; other site 266835007128 H-loop/switch region; other site 266835007129 TOBE domain; Region: TOBE_2; cl01440 266835007130 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266835007131 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835007132 Walker A/P-loop; other site 266835007133 ATP binding site [chemical binding]; other site 266835007134 Q-loop/lid; other site 266835007135 ABC transporter signature motif; other site 266835007136 Walker B; other site 266835007137 D-loop; other site 266835007138 H-loop/switch region; other site 266835007139 TOBE domain; Region: TOBE_2; cl01440 266835007140 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835007141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835007142 dimer interface [polypeptide binding]; other site 266835007143 conserved gate region; other site 266835007144 putative PBP binding loops; other site 266835007145 ABC-ATPase subunit interface; other site 266835007146 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835007147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835007148 dimer interface [polypeptide binding]; other site 266835007149 conserved gate region; other site 266835007150 putative PBP binding loops; other site 266835007151 ABC-ATPase subunit interface; other site 266835007152 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835007153 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266835007154 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835007155 Walker A/P-loop; other site 266835007156 ATP binding site [chemical binding]; other site 266835007157 Q-loop/lid; other site 266835007158 ABC transporter signature motif; other site 266835007159 Walker B; other site 266835007160 D-loop; other site 266835007161 H-loop/switch region; other site 266835007162 TOBE domain; Region: TOBE_2; cl01440 266835007163 Uncharacterised protein family (UPF0261); Region: UPF0261; cl02262 266835007164 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424 266835007165 Cupin domain; Region: Cupin_2; cl09118 266835007166 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 266835007167 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266835007168 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266835007169 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266835007170 active site 266835007171 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835007172 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 266835007173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835007174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835007175 dimer interface [polypeptide binding]; other site 266835007176 conserved gate region; other site 266835007177 putative PBP binding loops; other site 266835007178 ABC-ATPase subunit interface; other site 266835007179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835007180 dimer interface [polypeptide binding]; other site 266835007181 conserved gate region; other site 266835007182 putative PBP binding loops; other site 266835007183 ABC-ATPase subunit interface; other site 266835007184 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 266835007185 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835007186 Walker A/P-loop; other site 266835007187 ATP binding site [chemical binding]; other site 266835007188 Q-loop/lid; other site 266835007189 ABC transporter signature motif; other site 266835007190 Walker B; other site 266835007191 D-loop; other site 266835007192 H-loop/switch region; other site 266835007193 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835007194 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 266835007195 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835007196 Walker A/P-loop; other site 266835007197 ATP binding site [chemical binding]; other site 266835007198 Q-loop/lid; other site 266835007199 ABC transporter signature motif; other site 266835007200 Walker B; other site 266835007201 D-loop; other site 266835007202 H-loop/switch region; other site 266835007203 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 266835007204 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266835007205 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 266835007206 Walker A/P-loop; other site 266835007207 ATP binding site [chemical binding]; other site 266835007208 Q-loop/lid; other site 266835007209 ABC transporter signature motif; other site 266835007210 Walker B; other site 266835007211 D-loop; other site 266835007212 H-loop/switch region; other site 266835007213 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835007214 TM-ABC transporter signature motif; other site 266835007215 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 266835007216 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266835007217 putative ligand binding site [chemical binding]; other site 266835007218 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 266835007219 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835007220 DNA binding residues [nucleotide binding] 266835007221 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 266835007222 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 266835007223 catalytic residue [active] 266835007224 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 266835007225 N-acetylmannosamine kinase; Provisional; Region: PRK05082 266835007226 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835007227 Predicted kinase [General function prediction only]; Region: COG0645 266835007228 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266835007229 Helix-turn-helix domains; Region: HTH; cl00088 266835007230 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 266835007231 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 266835007232 NAD binding site [chemical binding]; other site 266835007233 substrate binding site [chemical binding]; other site 266835007234 putative active site [active] 266835007235 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 266835007236 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 266835007237 catalytic residues [active] 266835007238 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835007239 Helix-turn-helix domains; Region: HTH; cl00088 266835007240 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266835007241 putative effector binding pocket; other site 266835007242 dimerization interface [polypeptide binding]; other site 266835007243 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 266835007244 Uncharacterised protein family (UPF0156); Region: RHH_2; cl01448 266835007245 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 266835007246 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266835007247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835007248 putative substrate translocation pore; other site 266835007249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835007250 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 266835007251 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 266835007252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 266835007253 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 266835007254 Protein of unknown function (DUF419); Region: DUF419; cl15265 266835007255 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 266835007256 Clp amino terminal domain; Region: Clp_N; pfam02861 266835007257 Clp amino terminal domain; Region: Clp_N; pfam02861 266835007258 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835007259 Walker A motif; other site 266835007260 ATP binding site [chemical binding]; other site 266835007261 Walker B motif; other site 266835007262 arginine finger; other site 266835007263 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835007264 Walker A motif; other site 266835007265 ATP binding site [chemical binding]; other site 266835007266 Walker B motif; other site 266835007267 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 266835007268 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 266835007269 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 266835007270 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835007271 S-adenosylmethionine binding site [chemical binding]; other site 266835007272 peptide chain release factor 1; Validated; Region: prfA; PRK00591 266835007273 RF-1 domain; Region: RF-1; cl02875 266835007274 RF-1 domain; Region: RF-1; cl02875 266835007275 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 266835007276 GAF domain; Region: GAF; cl00853 266835007277 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 266835007278 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 266835007279 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 266835007280 aspartate kinase; Reviewed; Region: PRK06635 266835007281 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 266835007282 putative nucleotide binding site [chemical binding]; other site 266835007283 putative catalytic residues [active] 266835007284 putative Mg ion binding site [ion binding]; other site 266835007285 putative aspartate binding site [chemical binding]; other site 266835007286 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 266835007287 putative allosteric regulatory site; other site 266835007288 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 266835007289 putative allosteric regulatory residue; other site 266835007290 sensory histidine kinase AtoS; Provisional; Region: PRK11360 266835007291 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266835007292 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835007293 metal binding site [ion binding]; metal-binding site 266835007294 active site 266835007295 I-site; other site 266835007296 Putative glycolipid-binding; Region: Glycolipid_bind; cl01425 266835007297 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 266835007298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835007299 Flavin Reductases; Region: FlaRed; cl00801 266835007300 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 266835007301 active site 266835007302 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 266835007303 dimer interface [polypeptide binding]; other site 266835007304 non-prolyl cis peptide bond; other site 266835007305 insertion regions; other site 266835007306 Helix-turn-helix domains; Region: HTH; cl00088 266835007307 Helix-turn-helix domains; Region: HTH; cl00088 266835007308 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266835007309 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 266835007310 Predicted amidohydrolase [General function prediction only]; Region: COG0388 266835007311 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 266835007312 putative active site [active] 266835007313 catalytic triad [active] 266835007314 dimer interface [polypeptide binding]; other site 266835007315 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 266835007316 GSH binding site [chemical binding]; other site 266835007317 catalytic residues [active] 266835007318 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 266835007319 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266835007320 active site 266835007321 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835007322 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 266835007323 Flp/Fap pilin component; Region: Flp_Fap; cl01585 266835007324 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 266835007325 active site 266835007326 8-oxo-dGMP binding site [chemical binding]; other site 266835007327 nudix motif; other site 266835007328 metal binding site [ion binding]; metal-binding site 266835007329 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 266835007330 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835007331 Coenzyme A binding pocket [chemical binding]; other site 266835007332 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 266835007333 heterotetramer interface [polypeptide binding]; other site 266835007334 active site pocket [active] 266835007335 cleavage site 266835007336 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 266835007337 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 266835007338 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266835007339 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835007340 Helix-turn-helix domains; Region: HTH; cl00088 266835007341 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 266835007342 PPIC-type PPIASE domain; Region: Rotamase; cl08278 266835007343 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 266835007344 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835007345 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 266835007346 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266835007347 nucleotide binding region [chemical binding]; other site 266835007348 ATP-binding site [chemical binding]; other site 266835007349 hypothetical protein; Provisional; Region: PRK00183 266835007350 SEC-C motif; Region: SEC-C; pfam02810 266835007351 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 266835007352 MatE; Region: MatE; cl10513 266835007353 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 266835007354 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835007355 Creatinine amidohydrolase; Region: Creatininase; cl00618 266835007356 Uncharacterized conserved protein [Function unknown]; Region: COG3391 266835007357 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 266835007358 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 266835007359 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 266835007360 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 266835007361 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 266835007362 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 266835007363 active site 266835007364 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 266835007365 endonuclease III; Region: ENDO3c; smart00478 266835007366 minor groove reading motif; other site 266835007367 helix-hairpin-helix signature motif; other site 266835007368 substrate binding pocket [chemical binding]; other site 266835007369 active site 266835007370 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266835007371 active site 266835007372 HIGH motif; other site 266835007373 nucleotide binding site [chemical binding]; other site 266835007374 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266835007375 active site 266835007376 KMSKS motif; other site 266835007377 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 266835007378 EamA-like transporter family; Region: EamA; cl01037 266835007379 EamA-like transporter family; Region: EamA; cl01037 266835007380 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 266835007381 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266835007382 short chain dehydrogenase; Provisional; Region: PRK05693 266835007383 NADP binding site [chemical binding]; other site 266835007384 active site 266835007385 steroid binding site; other site 266835007386 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 266835007387 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 266835007388 Rhomboid family; Region: Rhomboid; cl11446 266835007389 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 266835007390 Ligand binding site [chemical binding]; other site 266835007391 Electron transfer flavoprotein domain; Region: ETF; pfam01012 266835007392 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 266835007393 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 266835007394 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 266835007395 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 266835007396 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835007397 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266835007398 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835007399 putative active site [active] 266835007400 heme pocket [chemical binding]; other site 266835007401 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835007402 PAS fold; Region: PAS_3; pfam08447 266835007403 putative active site [active] 266835007404 heme pocket [chemical binding]; other site 266835007405 PAS fold; Region: PAS; pfam00989 266835007406 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 266835007407 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835007408 metal binding site [ion binding]; metal-binding site 266835007409 active site 266835007410 I-site; other site 266835007411 Protein of unknown function (DUF1109); Region: DUF1109; cl02071 266835007412 RNA polymerase sigma factor; Provisional; Region: PRK12512 266835007413 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835007414 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835007415 DNA binding residues [nucleotide binding] 266835007416 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835007417 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835007418 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 266835007419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835007420 dimer interface [polypeptide binding]; other site 266835007421 conserved gate region; other site 266835007422 putative PBP binding loops; other site 266835007423 ABC-ATPase subunit interface; other site 266835007424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835007425 dimer interface [polypeptide binding]; other site 266835007426 conserved gate region; other site 266835007427 putative PBP binding loops; other site 266835007428 ABC-ATPase subunit interface; other site 266835007429 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835007430 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 266835007431 Walker A/P-loop; other site 266835007432 ATP binding site [chemical binding]; other site 266835007433 Q-loop/lid; other site 266835007434 ABC transporter signature motif; other site 266835007435 Walker B; other site 266835007436 D-loop; other site 266835007437 H-loop/switch region; other site 266835007438 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266835007439 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 266835007440 Walker A/P-loop; other site 266835007441 ATP binding site [chemical binding]; other site 266835007442 Q-loop/lid; other site 266835007443 ABC transporter signature motif; other site 266835007444 Walker B; other site 266835007445 D-loop; other site 266835007446 H-loop/switch region; other site 266835007447 TOBE domain; Region: TOBE_2; cl01440 266835007448 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835007449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835007450 dimer interface [polypeptide binding]; other site 266835007451 conserved gate region; other site 266835007452 putative PBP binding loops; other site 266835007453 ABC-ATPase subunit interface; other site 266835007454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835007455 dimer interface [polypeptide binding]; other site 266835007456 conserved gate region; other site 266835007457 putative PBP binding loops; other site 266835007458 ABC-ATPase subunit interface; other site 266835007459 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835007460 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835007461 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 266835007462 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 266835007463 PAS domain S-box; Region: sensory_box; TIGR00229 266835007464 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835007465 metal binding site [ion binding]; metal-binding site 266835007466 active site 266835007467 I-site; other site 266835007468 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835007469 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 266835007470 catalytic residues [active] 266835007471 argininosuccinate lyase; Provisional; Region: PRK00855 266835007472 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 266835007473 active sites [active] 266835007474 tetramer interface [polypeptide binding]; other site 266835007475 diaminopimelate decarboxylase; Region: lysA; TIGR01048 266835007476 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 266835007477 active site 266835007478 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266835007479 substrate binding site [chemical binding]; other site 266835007480 catalytic residues [active] 266835007481 dimer interface [polypeptide binding]; other site 266835007482 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835007483 dimerization interface [polypeptide binding]; other site 266835007484 putative DNA binding site [nucleotide binding]; other site 266835007485 putative Zn2+ binding site [ion binding]; other site 266835007486 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 266835007487 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 266835007488 tetramer interface [polypeptide binding]; other site 266835007489 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835007490 catalytic residue [active] 266835007491 TIGR02302 family protein; Region: aProt_lowcomp 266835007492 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 266835007493 ligand binding site [chemical binding]; other site 266835007494 dimer interface [polypeptide binding]; other site 266835007495 Helix-turn-helix domains; Region: HTH; cl00088 266835007496 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835007497 dimerization interface [polypeptide binding]; other site 266835007498 EamA-like transporter family; Region: EamA; cl01037 266835007499 Response regulator receiver domain; Region: Response_reg; pfam00072 266835007500 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835007501 active site 266835007502 phosphorylation site [posttranslational modification] 266835007503 intermolecular recognition site; other site 266835007504 dimerization interface [polypeptide binding]; other site 266835007505 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 266835007506 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 266835007507 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 266835007508 Walker A/P-loop; other site 266835007509 ATP binding site [chemical binding]; other site 266835007510 Q-loop/lid; other site 266835007511 ABC transporter signature motif; other site 266835007512 Walker B; other site 266835007513 D-loop; other site 266835007514 H-loop/switch region; other site 266835007515 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 266835007516 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 266835007517 putative active site [active] 266835007518 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 266835007519 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 266835007520 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266835007521 transcriptional regulator; Provisional; Region: PRK10632 266835007522 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 266835007523 putative effector binding pocket; other site 266835007524 putative dimerization interface [polypeptide binding]; other site 266835007525 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 266835007526 putative acyl-acceptor binding pocket; other site 266835007527 LysE type translocator; Region: LysE; cl00565 266835007528 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 266835007529 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835007530 active site 266835007531 catalytic tetrad [active] 266835007532 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 266835007533 putative active site pocket [active] 266835007534 dimerization interface [polypeptide binding]; other site 266835007535 putative catalytic residue [active] 266835007536 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; cl11537 266835007537 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266835007538 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 266835007539 substrate binding site [chemical binding]; other site 266835007540 ATP binding site [chemical binding]; other site 266835007541 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 266835007542 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835007543 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 266835007544 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835007545 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835007546 homodimer interface [polypeptide binding]; other site 266835007547 catalytic residue [active] 266835007548 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 266835007549 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835007550 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 266835007551 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835007552 S-adenosylmethionine binding site [chemical binding]; other site 266835007553 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 266835007554 ADP-ribose binding site [chemical binding]; other site 266835007555 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 266835007556 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 266835007557 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 266835007558 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 266835007559 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 266835007560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835007561 DREV methyltransferase; Region: DREV; pfam05219 266835007562 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 266835007563 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266835007564 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 266835007565 YhhN-like protein; Region: YhhN; cl01505 266835007566 aromatic amino acid exporter; Provisional; Region: PRK11689 266835007567 EamA-like transporter family; Region: EamA; cl01037 266835007568 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 266835007569 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 266835007570 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 266835007571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835007572 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 266835007573 Gag P30 core shell protein; Region: Gag_p30; pfam02093 266835007574 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835007575 Helix-turn-helix domains; Region: HTH; cl00088 266835007576 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266835007577 putative effector binding pocket; other site 266835007578 dimerization interface [polypeptide binding]; other site 266835007579 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 266835007580 putative hydrophobic ligand binding site [chemical binding]; other site 266835007581 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835007582 dimerization interface [polypeptide binding]; other site 266835007583 putative DNA binding site [nucleotide binding]; other site 266835007584 putative Zn2+ binding site [ion binding]; other site 266835007585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 266835007586 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 266835007587 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 266835007588 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 266835007589 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 266835007590 metal ion-dependent adhesion site (MIDAS); other site 266835007591 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 266835007592 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 266835007593 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 266835007594 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266835007595 HSP70 interaction site [polypeptide binding]; other site 266835007596 BolA-like protein; Region: BolA; cl00386 266835007597 hypothetical protein; Validated; Region: PRK07586 266835007598 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266835007599 PYR/PP interface [polypeptide binding]; other site 266835007600 dimer interface [polypeptide binding]; other site 266835007601 TPP binding site [chemical binding]; other site 266835007602 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 266835007603 TPP-binding site [chemical binding]; other site 266835007604 dimer interface [polypeptide binding]; other site 266835007605 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 266835007606 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835007607 substrate binding pocket [chemical binding]; other site 266835007608 FOG: CBS domain [General function prediction only]; Region: COG0517 266835007609 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 266835007610 Transporter associated domain; Region: CorC_HlyC; cl08393 266835007611 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 266835007612 active site 266835007613 dimer interface [polypeptide binding]; other site 266835007614 metal binding site [ion binding]; metal-binding site 266835007615 shikimate kinase; Provisional; Region: PRK13946 266835007616 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 266835007617 ADP binding site [chemical binding]; other site 266835007618 magnesium binding site [ion binding]; other site 266835007619 putative shikimate binding site; other site 266835007620 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 266835007621 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266835007622 DNA binding site [nucleotide binding] 266835007623 Int/Topo IB signature motif; other site 266835007624 active site 266835007625 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 266835007626 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 266835007627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 266835007628 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 266835007629 CPxP motif; other site 266835007630 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 266835007631 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835007632 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 266835007633 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 266835007634 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 266835007635 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 266835007636 metal binding site [ion binding]; metal-binding site 266835007637 putative dimer interface [polypeptide binding]; other site 266835007638 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 266835007639 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 266835007640 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 266835007641 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 266835007642 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 266835007643 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 266835007644 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266835007645 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835007646 Walker A/P-loop; other site 266835007647 ATP binding site [chemical binding]; other site 266835007648 Q-loop/lid; other site 266835007649 ABC transporter signature motif; other site 266835007650 Walker B; other site 266835007651 D-loop; other site 266835007652 H-loop/switch region; other site 266835007653 TOBE domain; Region: TOBE_2; cl01440 266835007654 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835007655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835007656 dimer interface [polypeptide binding]; other site 266835007657 conserved gate region; other site 266835007658 putative PBP binding loops; other site 266835007659 ABC-ATPase subunit interface; other site 266835007660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835007661 dimer interface [polypeptide binding]; other site 266835007662 conserved gate region; other site 266835007663 putative PBP binding loops; other site 266835007664 ABC-ATPase subunit interface; other site 266835007665 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835007666 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835007667 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 266835007668 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 266835007669 Predicted transcriptional regulator [Transcription]; Region: COG4189 266835007670 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835007671 dimerization interface [polypeptide binding]; other site 266835007672 putative DNA binding site [nucleotide binding]; other site 266835007673 putative Zn2+ binding site [ion binding]; other site 266835007674 Cupin domain; Region: Cupin_2; cl09118 266835007675 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266835007676 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 266835007677 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266835007678 putative ligand binding site [chemical binding]; other site 266835007679 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835007680 TM-ABC transporter signature motif; other site 266835007681 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835007682 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 266835007683 Walker A/P-loop; other site 266835007684 ATP binding site [chemical binding]; other site 266835007685 Q-loop/lid; other site 266835007686 ABC transporter signature motif; other site 266835007687 Walker B; other site 266835007688 D-loop; other site 266835007689 H-loop/switch region; other site 266835007690 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 266835007691 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 266835007692 Novosphingobium aromaticivorans carbohydrate kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_NaCK_like; cd07772 266835007693 N- and C-terminal domain interface [polypeptide binding]; other site 266835007694 putative active site [active] 266835007695 putative MgATP binding site [chemical binding]; other site 266835007696 catalytic site [active] 266835007697 metal binding site [ion binding]; metal-binding site 266835007698 putative carbohydrate binding site [chemical binding]; other site 266835007699 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266835007700 Helix-turn-helix domains; Region: HTH; cl00088 266835007701 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 266835007702 Uncharacterized conserved protein [Function unknown]; Region: COG3347 266835007703 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 266835007704 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 266835007705 N- and C-terminal domain interface [polypeptide binding]; other site 266835007706 D-xylulose kinase; Region: XylB; TIGR01312 266835007707 active site 266835007708 MgATP binding site [chemical binding]; other site 266835007709 catalytic site [active] 266835007710 metal binding site [ion binding]; metal-binding site 266835007711 carbohydrate binding site [chemical binding]; other site 266835007712 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 266835007713 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266835007714 active site 266835007715 motif I; other site 266835007716 motif II; other site 266835007717 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266835007718 motif II; other site 266835007719 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 266835007720 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 266835007721 DNA binding residues [nucleotide binding] 266835007722 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 266835007723 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 266835007724 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 266835007725 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 266835007726 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 266835007727 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 266835007728 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 266835007729 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 266835007730 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 266835007731 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 266835007732 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 266835007733 Glucitol operon activator protein (GutM); Region: GutM; cl01890 266835007734 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 266835007735 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266835007736 active site 266835007737 motif I; other site 266835007738 motif II; other site 266835007739 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 266835007740 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 266835007741 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266835007742 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 266835007743 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266835007744 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835007745 Walker A/P-loop; other site 266835007746 ATP binding site [chemical binding]; other site 266835007747 Q-loop/lid; other site 266835007748 ABC transporter signature motif; other site 266835007749 Walker B; other site 266835007750 D-loop; other site 266835007751 H-loop/switch region; other site 266835007752 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835007753 dimer interface [polypeptide binding]; other site 266835007754 conserved gate region; other site 266835007755 putative PBP binding loops; other site 266835007756 ABC-ATPase subunit interface; other site 266835007757 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835007758 dimer interface [polypeptide binding]; other site 266835007759 conserved gate region; other site 266835007760 putative PBP binding loops; other site 266835007761 ABC-ATPase subunit interface; other site 266835007762 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 266835007763 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835007764 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 266835007765 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266835007766 E3 interaction surface; other site 266835007767 lipoyl attachment site [posttranslational modification]; other site 266835007768 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 266835007769 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 266835007770 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 266835007771 alpha subunit interface [polypeptide binding]; other site 266835007772 TPP binding site [chemical binding]; other site 266835007773 heterodimer interface [polypeptide binding]; other site 266835007774 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266835007775 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 266835007776 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 266835007777 tetramer interface [polypeptide binding]; other site 266835007778 TPP-binding site [chemical binding]; other site 266835007779 heterodimer interface [polypeptide binding]; other site 266835007780 phosphorylation loop region [posttranslational modification] 266835007781 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 266835007782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835007783 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266835007784 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 266835007785 active site 266835007786 metal binding site [ion binding]; metal-binding site 266835007787 hexamer interface [polypeptide binding]; other site 266835007788 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835007789 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 266835007790 NAD(P) binding site [chemical binding]; other site 266835007791 active site 266835007792 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 266835007793 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 266835007794 nucleophile elbow; other site 266835007795 Patatin phospholipase; Region: DUF3734; pfam12536 266835007796 Phosphate transporter family; Region: PHO4; cl00396 266835007797 Phosphate transporter family; Region: PHO4; cl00396 266835007798 Helix-turn-helix domains; Region: HTH; cl00088 266835007799 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 266835007800 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 266835007801 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835007802 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835007803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835007804 dimer interface [polypeptide binding]; other site 266835007805 conserved gate region; other site 266835007806 putative PBP binding loops; other site 266835007807 ABC-ATPase subunit interface; other site 266835007808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835007809 dimer interface [polypeptide binding]; other site 266835007810 conserved gate region; other site 266835007811 putative PBP binding loops; other site 266835007812 ABC-ATPase subunit interface; other site 266835007813 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 266835007814 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 266835007815 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 266835007816 dimer interface [polypeptide binding]; other site 266835007817 active site 266835007818 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 266835007819 substrate binding site [chemical binding]; other site 266835007820 ATP binding site [chemical binding]; other site 266835007821 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266835007822 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 266835007823 Walker A/P-loop; other site 266835007824 ATP binding site [chemical binding]; other site 266835007825 Q-loop/lid; other site 266835007826 ABC transporter signature motif; other site 266835007827 Walker B; other site 266835007828 D-loop; other site 266835007829 H-loop/switch region; other site 266835007830 TOBE domain; Region: TOBE_2; cl01440 266835007831 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835007832 Helix-turn-helix domains; Region: HTH; cl00088 266835007833 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266835007834 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266835007835 multidrug efflux protein; Reviewed; Region: PRK09579 266835007836 Protein export membrane protein; Region: SecD_SecF; cl14618 266835007837 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 266835007838 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835007839 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835007840 DNA binding site [nucleotide binding] 266835007841 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835007842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835007843 active site 266835007844 phosphorylation site [posttranslational modification] 266835007845 intermolecular recognition site; other site 266835007846 dimerization interface [polypeptide binding]; other site 266835007847 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835007848 DNA binding site [nucleotide binding] 266835007849 GAF domain; Region: GAF; cl00853 266835007850 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 266835007851 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835007852 putative active site [active] 266835007853 heme pocket [chemical binding]; other site 266835007854 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 266835007855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835007856 ATP binding site [chemical binding]; other site 266835007857 Mg2+ binding site [ion binding]; other site 266835007858 G-X-G motif; other site 266835007859 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266835007860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835007861 active site 266835007862 phosphorylation site [posttranslational modification] 266835007863 intermolecular recognition site; other site 266835007864 dimerization interface [polypeptide binding]; other site 266835007865 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 266835007866 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 266835007867 [2Fe-2S] cluster binding site [ion binding]; other site 266835007868 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 266835007869 alpha subunit interface [polypeptide binding]; other site 266835007870 active site 266835007871 substrate binding site [chemical binding]; other site 266835007872 Fe binding site [ion binding]; other site 266835007873 hypothetical protein; Provisional; Region: PRK07036 266835007874 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835007875 inhibitor-cofactor binding pocket; inhibition site 266835007876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835007877 catalytic residue [active] 266835007878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835007879 dimer interface [polypeptide binding]; other site 266835007880 conserved gate region; other site 266835007881 putative PBP binding loops; other site 266835007882 ABC-ATPase subunit interface; other site 266835007883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835007884 dimer interface [polypeptide binding]; other site 266835007885 conserved gate region; other site 266835007886 putative PBP binding loops; other site 266835007887 ABC-ATPase subunit interface; other site 266835007888 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 266835007889 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 266835007890 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835007891 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835007892 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835007893 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835007894 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835007895 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835007896 Helix-turn-helix domains; Region: HTH; cl00088 266835007897 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 266835007898 phosphoethanolamine N-methyltransferase; Region: PLN02336 266835007899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835007900 S-adenosylmethionine binding site [chemical binding]; other site 266835007901 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 266835007902 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835007903 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 266835007904 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835007905 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835007906 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 266835007907 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 266835007908 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835007909 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 266835007910 active site 266835007911 dimer interface [polypeptide binding]; other site 266835007912 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835007913 Predicted esterase [General function prediction only]; Region: COG0400 266835007914 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835007915 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 266835007916 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835007917 Zn binding site [ion binding]; other site 266835007918 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 266835007919 Zn binding site [ion binding]; other site 266835007920 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 266835007921 Sulfatase; Region: Sulfatase; cl10460 266835007922 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 266835007923 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 266835007924 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 266835007925 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 266835007926 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266835007927 GAF domain; Region: GAF; cl00853 266835007928 putative diguanylate cyclase; Provisional; Region: PRK09776 266835007929 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 266835007930 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266835007931 Histidine kinase; Region: HisKA_2; cl06527 266835007932 CsbD-like; Region: CsbD; cl01888 266835007933 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266835007934 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266835007935 ligand binding site [chemical binding]; other site 266835007936 flexible hinge region; other site 266835007937 Helix-turn-helix domains; Region: HTH; cl00088 266835007938 putative switch regulator; other site 266835007939 non-specific DNA interactions [nucleotide binding]; other site 266835007940 DNA binding site [nucleotide binding] 266835007941 sequence specific DNA binding site [nucleotide binding]; other site 266835007942 putative cAMP binding site [chemical binding]; other site 266835007943 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266835007944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835007945 active site 266835007946 phosphorylation site [posttranslational modification] 266835007947 intermolecular recognition site; other site 266835007948 dimerization interface [polypeptide binding]; other site 266835007949 RNA polymerase sigma factor; Provisional; Region: PRK12547 266835007950 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835007951 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835007952 DNA binding residues [nucleotide binding] 266835007953 two-component response regulator; Provisional; Region: PRK09191 266835007954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835007955 active site 266835007956 phosphorylation site [posttranslational modification] 266835007957 intermolecular recognition site; other site 266835007958 dimerization interface [polypeptide binding]; other site 266835007959 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266835007960 Histidine kinase; Region: HisKA_2; cl06527 266835007961 CHASE domain; Region: CHASE; cl01369 266835007962 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266835007963 Histidine kinase; Region: HisKA_2; cl06527 266835007964 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266835007965 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835007966 Walker A/P-loop; other site 266835007967 ATP binding site [chemical binding]; other site 266835007968 Q-loop/lid; other site 266835007969 ABC transporter signature motif; other site 266835007970 Walker B; other site 266835007971 D-loop; other site 266835007972 H-loop/switch region; other site 266835007973 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835007974 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835007975 TM-ABC transporter signature motif; other site 266835007976 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 266835007977 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 266835007978 putative ligand binding site [chemical binding]; other site 266835007979 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 266835007980 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 266835007981 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 266835007982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835007983 active site 266835007984 phosphorylation site [posttranslational modification] 266835007985 intermolecular recognition site; other site 266835007986 dimerization interface [polypeptide binding]; other site 266835007987 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835007988 DNA binding site [nucleotide binding] 266835007989 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 266835007990 PhoU domain; Region: PhoU; pfam01895 266835007991 PhoU domain; Region: PhoU; pfam01895 266835007992 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 266835007993 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 266835007994 Walker A/P-loop; other site 266835007995 ATP binding site [chemical binding]; other site 266835007996 Q-loop/lid; other site 266835007997 ABC transporter signature motif; other site 266835007998 Walker B; other site 266835007999 D-loop; other site 266835008000 H-loop/switch region; other site 266835008001 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 266835008002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835008003 dimer interface [polypeptide binding]; other site 266835008004 conserved gate region; other site 266835008005 putative PBP binding loops; other site 266835008006 ABC-ATPase subunit interface; other site 266835008007 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 266835008008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835008009 dimer interface [polypeptide binding]; other site 266835008010 conserved gate region; other site 266835008011 putative PBP binding loops; other site 266835008012 ABC-ATPase subunit interface; other site 266835008013 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835008014 PAS fold; Region: PAS_4; pfam08448 266835008015 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835008016 putative active site [active] 266835008017 heme pocket [chemical binding]; other site 266835008018 PAS fold; Region: PAS_7; pfam12860 266835008019 PAS fold; Region: PAS_7; pfam12860 266835008020 hypothetical protein; Provisional; Region: PRK13560 266835008021 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 266835008022 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 266835008023 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 266835008024 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835008025 dimer interface [polypeptide binding]; other site 266835008026 phosphorylation site [posttranslational modification] 266835008027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835008028 ATP binding site [chemical binding]; other site 266835008029 Mg2+ binding site [ion binding]; other site 266835008030 G-X-G motif; other site 266835008031 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266835008032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835008033 active site 266835008034 phosphorylation site [posttranslational modification] 266835008035 intermolecular recognition site; other site 266835008036 dimerization interface [polypeptide binding]; other site 266835008037 Response regulator receiver domain; Region: Response_reg; pfam00072 266835008038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835008039 active site 266835008040 phosphorylation site [posttranslational modification] 266835008041 intermolecular recognition site; other site 266835008042 dimerization interface [polypeptide binding]; other site 266835008043 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 266835008044 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 266835008045 N-terminal domain interface [polypeptide binding]; other site 266835008046 dimer interface [polypeptide binding]; other site 266835008047 substrate binding pocket (H-site) [chemical binding]; other site 266835008048 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 266835008049 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835008050 Zn binding site [ion binding]; other site 266835008051 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835008052 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 266835008053 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 266835008054 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266835008055 RNA binding surface [nucleotide binding]; other site 266835008056 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 266835008057 active site 266835008058 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 266835008059 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 266835008060 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835008061 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835008062 DNA binding residues [nucleotide binding] 266835008063 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 266835008064 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266835008065 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 266835008066 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 266835008067 dimer interface [polypeptide binding]; other site 266835008068 decamer (pentamer of dimers) interface [polypeptide binding]; other site 266835008069 catalytic triad [active] 266835008070 Cell division protein ZapA; Region: ZapA; cl01146 266835008071 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 266835008072 transketolase; Reviewed; Region: PRK05899 266835008073 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 266835008074 TPP-binding site [chemical binding]; other site 266835008075 dimer interface [polypeptide binding]; other site 266835008076 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 266835008077 PYR/PP interface [polypeptide binding]; other site 266835008078 dimer interface [polypeptide binding]; other site 266835008079 TPP binding site [chemical binding]; other site 266835008080 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266835008081 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 266835008082 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 266835008083 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 266835008084 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 266835008085 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 266835008086 Phosphoglycerate kinase; Region: PGK; pfam00162 266835008087 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 266835008088 substrate binding site [chemical binding]; other site 266835008089 hinge regions; other site 266835008090 ADP binding site [chemical binding]; other site 266835008091 catalytic site [active] 266835008092 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 266835008093 active site 266835008094 intersubunit interface [polypeptide binding]; other site 266835008095 catalytic residue [active] 266835008096 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 266835008097 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 266835008098 active site 266835008099 catalytic triad [active] 266835008100 oxyanion hole [active] 266835008101 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 266835008102 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835008103 Zn binding site [ion binding]; other site 266835008104 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 266835008105 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835008106 Zn binding site [ion binding]; other site 266835008107 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 266835008108 conserved cys residue [active] 266835008109 Predicted transcriptional regulator [Transcription]; Region: COG2378 266835008110 Helix-turn-helix domains; Region: HTH; cl00088 266835008111 Protein of unknown function (DUF1013); Region: DUF1013; cl11533 266835008112 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 266835008113 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 266835008114 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 266835008115 NAD(P) binding site [chemical binding]; other site 266835008116 Protein of unknown function (DUF1192); Region: DUF1192; cl11573 266835008117 putative MFS family transporter protein; Provisional; Region: PRK03633 266835008118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835008119 putative substrate translocation pore; other site 266835008120 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835008121 dimerization interface [polypeptide binding]; other site 266835008122 putative DNA binding site [nucleotide binding]; other site 266835008123 putative Zn2+ binding site [ion binding]; other site 266835008124 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 266835008125 putative hydrophobic ligand binding site [chemical binding]; other site 266835008126 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835008127 dimerization interface [polypeptide binding]; other site 266835008128 putative DNA binding site [nucleotide binding]; other site 266835008129 putative Zn2+ binding site [ion binding]; other site 266835008130 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835008131 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 266835008132 C-terminal domain interface [polypeptide binding]; other site 266835008133 GSH binding site (G-site) [chemical binding]; other site 266835008134 dimer interface [polypeptide binding]; other site 266835008135 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 266835008136 N-terminal domain interface [polypeptide binding]; other site 266835008137 dimer interface [polypeptide binding]; other site 266835008138 substrate binding pocket (H-site) [chemical binding]; other site 266835008139 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835008140 homoserine O-acetyltransferase; Provisional; Region: metX; cl15472 266835008141 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835008142 Helix-turn-helix domains; Region: HTH; cl00088 266835008143 Domain of unknown function (DUF336); Region: DUF336; cl01249 266835008144 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 266835008145 Transglycosylase; Region: Transgly; cl07896 266835008146 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 266835008147 substrate binding pocket [chemical binding]; other site 266835008148 aspartate-rich region 1; other site 266835008149 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 266835008150 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 266835008151 NADP binding site [chemical binding]; other site 266835008152 homodimer interface [polypeptide binding]; other site 266835008153 active site 266835008154 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266835008155 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835008156 dimer interface [polypeptide binding]; other site 266835008157 phosphorylation site [posttranslational modification] 266835008158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835008159 ATP binding site [chemical binding]; other site 266835008160 Mg2+ binding site [ion binding]; other site 266835008161 G-X-G motif; other site 266835008162 Response regulator receiver domain; Region: Response_reg; pfam00072 266835008163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835008164 active site 266835008165 phosphorylation site [posttranslational modification] 266835008166 intermolecular recognition site; other site 266835008167 dimerization interface [polypeptide binding]; other site 266835008168 Response regulator receiver domain; Region: Response_reg; pfam00072 266835008169 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835008170 active site 266835008171 phosphorylation site [posttranslational modification] 266835008172 intermolecular recognition site; other site 266835008173 dimerization interface [polypeptide binding]; other site 266835008174 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835008175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835008176 S-adenosylmethionine binding site [chemical binding]; other site 266835008177 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 266835008178 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227 266835008179 P-loop motif; other site 266835008180 ATP binding site [chemical binding]; other site 266835008181 Chloramphenicol (Cm) binding site [chemical binding]; other site 266835008182 catalytic residue [active] 266835008183 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 266835008184 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266835008185 catalytic residue [active] 266835008186 Sporulation related domain; Region: SPOR; cl10051 266835008187 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 266835008188 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694; cl15446 266835008189 Protein of unknown function (DUF465); Region: DUF465; cl01070 266835008190 Protein of unknown function (DUF465); Region: DUF465; cl01070 266835008191 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266835008192 Helix-turn-helix domains; Region: HTH; cl00088 266835008193 Bacterial transcriptional regulator; Region: IclR; pfam01614 266835008194 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266835008195 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835008196 substrate binding pocket [chemical binding]; other site 266835008197 membrane-bound complex binding site; other site 266835008198 hinge residues; other site 266835008199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835008200 dimer interface [polypeptide binding]; other site 266835008201 conserved gate region; other site 266835008202 putative PBP binding loops; other site 266835008203 ABC-ATPase subunit interface; other site 266835008204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835008205 dimer interface [polypeptide binding]; other site 266835008206 conserved gate region; other site 266835008207 putative PBP binding loops; other site 266835008208 ABC-ATPase subunit interface; other site 266835008209 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266835008210 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 266835008211 Walker A/P-loop; other site 266835008212 ATP binding site [chemical binding]; other site 266835008213 Q-loop/lid; other site 266835008214 ABC transporter signature motif; other site 266835008215 Walker B; other site 266835008216 D-loop; other site 266835008217 H-loop/switch region; other site 266835008218 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 266835008219 homotrimer interaction site [polypeptide binding]; other site 266835008220 putative active site [active] 266835008221 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266835008222 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835008223 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266835008224 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835008225 catalytic residue [active] 266835008226 catalytic residue [active] 266835008227 RNA polymerase sigma factor; Provisional; Region: PRK11924 266835008228 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835008229 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835008230 DNA binding residues [nucleotide binding] 266835008231 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 266835008232 AIR carboxylase; Region: AIRC; cl00310 266835008233 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 266835008234 ATP-grasp domain; Region: ATP-grasp_4; cl03087 266835008235 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 266835008236 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 266835008237 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835008238 binding surface 266835008239 TPR motif; other site 266835008240 TPR repeat; Region: TPR_11; pfam13414 266835008241 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835008242 pyruvate kinase; Provisional; Region: PRK06247 266835008243 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 266835008244 domain interfaces; other site 266835008245 active site 266835008246 Protein of unknown function (DUF1036); Region: DUF1036; cl02296 266835008247 N-formylglutamate amidohydrolase; Region: FGase; cl01522 266835008248 Protein of unknown function (DUF1244); Region: DUF1244; cl01385 266835008249 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266835008250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835008251 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835008252 Helix-turn-helix domains; Region: HTH; cl00088 266835008253 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835008254 dimerization interface [polypeptide binding]; other site 266835008255 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835008256 atypical (a) SDRs, subgroup 3; Region: SDR_a3; cd05229 266835008257 putative NAD(P) binding site [chemical binding]; other site 266835008258 putative active site [active] 266835008259 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 266835008260 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 266835008261 Protein export membrane protein; Region: SecD_SecF; cl14618 266835008262 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266835008263 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266835008264 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266835008265 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266835008266 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 266835008267 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266835008268 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266835008269 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266835008270 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266835008271 catalytic loop [active] 266835008272 iron binding site [ion binding]; other site 266835008273 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266835008274 Helix-turn-helix domains; Region: HTH; cl00088 266835008275 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 266835008276 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 266835008277 active site 266835008278 nucleophile elbow; other site 266835008279 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 266835008280 dimer interface [polypeptide binding]; other site 266835008281 Citrate synthase; Region: Citrate_synt; pfam00285 266835008282 active site 266835008283 citrylCoA binding site [chemical binding]; other site 266835008284 oxalacetate/citrate binding site [chemical binding]; other site 266835008285 coenzyme A binding site [chemical binding]; other site 266835008286 catalytic triad [active] 266835008287 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 266835008288 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 266835008289 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 266835008290 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 266835008291 dimer interface [polypeptide binding]; other site 266835008292 active site 266835008293 oxalacetate/citrate binding site [chemical binding]; other site 266835008294 citrylCoA binding site [chemical binding]; other site 266835008295 coenzyme A binding site [chemical binding]; other site 266835008296 catalytic triad [active] 266835008297 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 266835008298 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 266835008299 conserved cys residue [active] 266835008300 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835008301 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835008302 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 266835008303 active site residue [active] 266835008304 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 266835008305 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 266835008306 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 266835008307 putative acyltransferase; Provisional; Region: PRK05790 266835008308 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266835008309 dimer interface [polypeptide binding]; other site 266835008310 active site 266835008311 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 266835008312 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 266835008313 NAD(P) binding site [chemical binding]; other site 266835008314 homotetramer interface [polypeptide binding]; other site 266835008315 homodimer interface [polypeptide binding]; other site 266835008316 active site 266835008317 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835008318 FAD binding domain; Region: FAD_binding_3; pfam01494 266835008319 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835008320 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835008321 Helix-turn-helix domains; Region: HTH; cl00088 266835008322 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835008323 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266835008324 nucleotide binding region [chemical binding]; other site 266835008325 Superfamily II helicase [General function prediction only]; Region: COG1204 266835008326 ATP-binding site [chemical binding]; other site 266835008327 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266835008328 RNA binding surface [nucleotide binding]; other site 266835008329 Ferredoxin [Energy production and conversion]; Region: COG1146 266835008330 4Fe-4S binding domain; Region: Fer4; cl02805 266835008331 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 266835008332 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 266835008333 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266835008334 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 266835008335 Walker A/P-loop; other site 266835008336 ATP binding site [chemical binding]; other site 266835008337 Q-loop/lid; other site 266835008338 ABC transporter signature motif; other site 266835008339 Walker B; other site 266835008340 D-loop; other site 266835008341 H-loop/switch region; other site 266835008342 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266835008343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835008344 dimer interface [polypeptide binding]; other site 266835008345 conserved gate region; other site 266835008346 putative PBP binding loops; other site 266835008347 ABC-ATPase subunit interface; other site 266835008348 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266835008349 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835008350 substrate binding pocket [chemical binding]; other site 266835008351 membrane-bound complex binding site; other site 266835008352 hinge residues; other site 266835008353 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 266835008354 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835008355 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835008356 DNA binding residues [nucleotide binding] 266835008357 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 266835008358 Peptidase family M48; Region: Peptidase_M48; cl12018 266835008359 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 266835008360 ABC-type thiamine tranport system; part of the binding-protein-dependent transport system tbpA-thiPQ for thiamine and TPP. Probably responsible for the translocation of thiamine across the membrane. ABC transporters are a large family of proteins...; Region: ABC_ThiQ_thiamine_transporter; cd03298 266835008361 Walker A/P-loop; other site 266835008362 ATP binding site [chemical binding]; other site 266835008363 Q-loop/lid; other site 266835008364 ABC transporter signature motif; other site 266835008365 Walker B; other site 266835008366 D-loop; other site 266835008367 H-loop/switch region; other site 266835008368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835008369 dimer interface [polypeptide binding]; other site 266835008370 conserved gate region; other site 266835008371 putative PBP binding loops; other site 266835008372 ABC-ATPase subunit interface; other site 266835008373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835008374 dimer interface [polypeptide binding]; other site 266835008375 conserved gate region; other site 266835008376 putative PBP binding loops; other site 266835008377 ABC-ATPase subunit interface; other site 266835008378 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835008379 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 266835008380 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 266835008381 Thiamine pyrophosphokinase; Region: TPK; cd07995 266835008382 active site 266835008383 dimerization interface [polypeptide binding]; other site 266835008384 thiamine binding site [chemical binding]; other site 266835008385 ABC transporter ATPase component; Reviewed; Region: PRK11147 266835008386 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 266835008387 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 266835008388 Post-segregation antitoxin CcdA; Region: CcdA; cl02188 266835008389 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 266835008390 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 266835008391 GDP-binding site [chemical binding]; other site 266835008392 ACT binding site; other site 266835008393 IMP binding site; other site 266835008394 EamA-like transporter family; Region: EamA; cl01037 266835008395 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 266835008396 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 266835008397 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835008398 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 266835008399 putative L-serine binding site [chemical binding]; other site 266835008400 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 266835008401 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835008402 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 266835008403 catalytic residue [active] 266835008404 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 266835008405 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 266835008406 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 266835008407 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 266835008408 active site 266835008409 substrate binding site [chemical binding]; other site 266835008410 metal binding site [ion binding]; metal-binding site 266835008411 FtsH Extracellular; Region: FtsH_ext; pfam06480 266835008412 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 266835008413 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835008414 Walker A motif; other site 266835008415 ATP binding site [chemical binding]; other site 266835008416 Walker B motif; other site 266835008417 arginine finger; other site 266835008418 Peptidase family M41; Region: Peptidase_M41; pfam01434 266835008419 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 266835008420 Ligand Binding Site [chemical binding]; other site 266835008421 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 266835008422 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 266835008423 putative outer membrane lipoprotein; Provisional; Region: PRK09967 266835008424 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266835008425 ligand binding site [chemical binding]; other site 266835008426 translocation protein TolB; Provisional; Region: tolB; PRK05137 266835008427 TolB amino-terminal domain; Region: TolB_N; cl00639 266835008428 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 266835008429 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 266835008430 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 266835008431 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 266835008432 Gram-negative bacterial tonB protein; Region: TonB; cl10048 266835008433 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 266835008434 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 266835008435 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266835008436 active site 266835008437 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 266835008438 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 266835008439 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266835008440 putative active site [active] 266835008441 putative metal binding site [ion binding]; other site 266835008442 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 266835008443 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835008444 Walker A motif; other site 266835008445 ATP binding site [chemical binding]; other site 266835008446 Walker B motif; other site 266835008447 arginine finger; other site 266835008448 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 266835008449 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 266835008450 RuvA N terminal domain; Region: RuvA_N; pfam01330 266835008451 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 266835008452 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 266835008453 putative active site [active] 266835008454 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 266835008455 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 266835008456 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 266835008457 active site 266835008458 putative DNA-binding cleft [nucleotide binding]; other site 266835008459 dimer interface [polypeptide binding]; other site 266835008460 Protein of unknown function (DUF1465); Region: DUF1465; cl11562 266835008461 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 266835008462 Methyltransferase domain; Region: Methyltransf_31; pfam13847 266835008463 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835008464 S-adenosylmethionine binding site [chemical binding]; other site 266835008465 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835008466 Helix-turn-helix domains; Region: HTH; cl00088 266835008467 EamA-like transporter family; Region: EamA; cl01037 266835008468 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 266835008469 thiamine phosphate binding site [chemical binding]; other site 266835008470 active site 266835008471 pyrophosphate binding site [ion binding]; other site 266835008472 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266835008473 Sel1 repeat; Region: Sel1; cl02723 266835008474 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 266835008475 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266835008476 putative NAD(P) binding site [chemical binding]; other site 266835008477 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835008478 Helix-turn-helix domains; Region: HTH; cl00088 266835008479 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266835008480 dimerization interface [polypeptide binding]; other site 266835008481 elongation factor P; Validated; Region: PRK00529 266835008482 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 266835008483 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 266835008484 RNA binding site [nucleotide binding]; other site 266835008485 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 266835008486 RNA binding site [nucleotide binding]; other site 266835008487 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 266835008488 active site 266835008489 dimerization interface [polypeptide binding]; other site 266835008490 Haemolysin-III related; Region: HlyIII; cl03831 266835008491 hypothetical protein; Validated; Region: PRK09039 266835008492 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266835008493 ligand binding site [chemical binding]; other site 266835008494 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 266835008495 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 266835008496 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 266835008497 active site 266835008498 Zn binding site [ion binding]; other site 266835008499 Domain of Unknown Function with PDB structure; Region: DUF3857; pfam12969 266835008500 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 266835008501 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 266835008502 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 266835008503 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 266835008504 Walker A/P-loop; other site 266835008505 ATP binding site [chemical binding]; other site 266835008506 Q-loop/lid; other site 266835008507 ABC transporter signature motif; other site 266835008508 Walker B; other site 266835008509 D-loop; other site 266835008510 H-loop/switch region; other site 266835008511 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 266835008512 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835008513 Helix-turn-helix domains; Region: HTH; cl00088 266835008514 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835008515 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 266835008516 NAD(P) binding site [chemical binding]; other site 266835008517 active site 266835008518 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 266835008519 Rdx family; Region: Rdx; cl01407 266835008520 Domain of unknown function DUF28; Region: DUF28; cl00361 266835008521 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835008522 dimerization interface [polypeptide binding]; other site 266835008523 putative DNA binding site [nucleotide binding]; other site 266835008524 putative Zn2+ binding site [ion binding]; other site 266835008525 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 266835008526 hydrophobic ligand binding site; other site 266835008527 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901 266835008528 putative hydrophobic ligand binding site [chemical binding]; other site 266835008529 Integral membrane protein TerC family; Region: TerC; cl10468 266835008530 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266835008531 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 266835008532 putative active site [active] 266835008533 metal binding site [ion binding]; metal-binding site 266835008534 homodimer binding site [polypeptide binding]; other site 266835008535 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 266835008536 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835008537 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 266835008538 Walker A motif; other site 266835008539 ATP binding site [chemical binding]; other site 266835008540 Walker B motif; other site 266835008541 arginine finger; other site 266835008542 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 266835008543 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835008544 Coenzyme A binding pocket [chemical binding]; other site 266835008545 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 266835008546 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266835008547 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 266835008548 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 266835008549 Low molecular weight phosphatase family; Region: LMWPc; cd00115 266835008550 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 266835008551 active site 266835008552 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; cl11480 266835008553 pyruvate carboxylase; Reviewed; Region: PRK12999 266835008554 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266835008555 ATP-grasp domain; Region: ATP-grasp_4; cl03087 266835008556 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 266835008557 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 266835008558 active site 266835008559 catalytic residues [active] 266835008560 metal binding site [ion binding]; metal-binding site 266835008561 homodimer binding site [polypeptide binding]; other site 266835008562 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266835008563 carboxyltransferase (CT) interaction site; other site 266835008564 biotinylation site [posttranslational modification]; other site 266835008565 leucine ABC transporter subunit substrate-binding protein LivK; Provisional; Region: PRK15404 266835008566 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 266835008567 dimerization interface [polypeptide binding]; other site 266835008568 ligand binding site [chemical binding]; other site 266835008569 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266835008570 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 266835008571 Walker A/P-loop; other site 266835008572 ATP binding site [chemical binding]; other site 266835008573 Q-loop/lid; other site 266835008574 ABC transporter signature motif; other site 266835008575 Walker B; other site 266835008576 D-loop; other site 266835008577 H-loop/switch region; other site 266835008578 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 266835008579 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 266835008580 Walker A/P-loop; other site 266835008581 ATP binding site [chemical binding]; other site 266835008582 Q-loop/lid; other site 266835008583 ABC transporter signature motif; other site 266835008584 Walker B; other site 266835008585 D-loop; other site 266835008586 H-loop/switch region; other site 266835008587 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 266835008588 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266835008589 TM-ABC transporter signature motif; other site 266835008590 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266835008591 TM-ABC transporter signature motif; other site 266835008592 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 266835008593 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 266835008594 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835008595 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835008596 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266835008597 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 266835008598 inhibitor site; inhibition site 266835008599 active site 266835008600 dimer interface [polypeptide binding]; other site 266835008601 catalytic residue [active] 266835008602 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835008603 DNA-binding site [nucleotide binding]; DNA binding site 266835008604 FCD domain; Region: FCD; cl11656 266835008605 Helix-turn-helix domains; Region: HTH; cl00088 266835008606 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266835008607 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 266835008608 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835008609 tetrameric interface [polypeptide binding]; other site 266835008610 NAD binding site [chemical binding]; other site 266835008611 catalytic residues [active] 266835008612 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835008613 Helix-turn-helix domains; Region: HTH; cl00088 266835008614 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835008615 dimerization interface [polypeptide binding]; other site 266835008616 PLA2_plant: Plant-specific sub-family of Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the glycerol backbone of...; Region: PLA2_plant; cd04706 266835008617 putative metal binding site; other site 266835008618 putative catalytic residues; other site 266835008619 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 266835008620 putative active site [active] 266835008621 catalytic site [active] 266835008622 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 266835008623 putative active site [active] 266835008624 catalytic site [active] 266835008625 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 266835008626 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835008627 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 266835008628 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 266835008629 YcjX-like family, DUF463; Region: DUF463; cl01193 266835008630 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 266835008631 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 266835008632 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 266835008633 active site 266835008634 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266835008635 dimer interface [polypeptide binding]; other site 266835008636 substrate binding site [chemical binding]; other site 266835008637 catalytic residues [active] 266835008638 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 266835008639 putative active site [active] 266835008640 Ap4A binding site [chemical binding]; other site 266835008641 nudix motif; other site 266835008642 putative metal binding site [ion binding]; other site 266835008643 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 266835008644 NodB motif; other site 266835008645 putative active site [active] 266835008646 putative catalytic site [active] 266835008647 Zn binding site [ion binding]; other site 266835008648 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 266835008649 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 266835008650 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 266835008651 protein binding site [polypeptide binding]; other site 266835008652 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 266835008653 Catalytic dyad [active] 266835008654 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 266835008655 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 266835008656 Domain of unknown function DUF143; Region: DUF143; cl00519 266835008657 Conserved TM helix; Region: TM_helix; pfam05552 266835008658 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266835008659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835008660 putative substrate translocation pore; other site 266835008661 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 266835008662 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 266835008663 active site 266835008664 (T/H)XGH motif; other site 266835008665 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 266835008666 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 266835008667 putative catalytic cysteine [active] 266835008668 gamma-glutamyl kinase; Provisional; Region: PRK05429 266835008669 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 266835008670 nucleotide binding site [chemical binding]; other site 266835008671 homotetrameric interface [polypeptide binding]; other site 266835008672 putative phosphate binding site [ion binding]; other site 266835008673 putative allosteric binding site; other site 266835008674 PUA domain; Region: PUA; cl00607 266835008675 GTPase CgtA; Reviewed; Region: obgE; PRK12299 266835008676 GTP1/OBG; Region: GTP1_OBG; pfam01018 266835008677 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 266835008678 G1 box; other site 266835008679 GTP/Mg2+ binding site [chemical binding]; other site 266835008680 Switch I region; other site 266835008681 G2 box; other site 266835008682 G3 box; other site 266835008683 Switch II region; other site 266835008684 G4 box; other site 266835008685 G5 box; other site 266835008686 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 266835008687 putative catalytic site [active] 266835008688 putative metal binding site [ion binding]; other site 266835008689 putative phosphate binding site [ion binding]; other site 266835008690 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 266835008691 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835008692 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 266835008693 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 266835008694 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 266835008695 Uncharacterized conserved protein [Function unknown]; Region: COG3743 266835008696 Helix-turn-helix domains; Region: HTH; cl00088 266835008697 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835008698 Integrase core domain; Region: rve; cl01316 266835008699 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 266835008700 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835008701 TPR motif; other site 266835008702 binding surface 266835008703 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835008704 binding surface 266835008705 TPR motif; other site 266835008706 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 266835008707 Porin subfamily; Region: Porin_2; pfam02530 266835008708 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835008709 DNA binding residues [nucleotide binding] 266835008710 dimerization interface [polypeptide binding]; other site 266835008711 multiple promoter invertase; Provisional; Region: mpi; PRK13413 266835008712 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 266835008713 catalytic residues [active] 266835008714 catalytic nucleophile [active] 266835008715 Presynaptic Site I dimer interface [polypeptide binding]; other site 266835008716 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 266835008717 Synaptic Flat tetramer interface [polypeptide binding]; other site 266835008718 Synaptic Site I dimer interface [polypeptide binding]; other site 266835008719 DNA binding site [nucleotide binding] 266835008720 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 266835008721 DNA-binding interface [nucleotide binding]; DNA binding site 266835008722 integrase; Provisional; Region: PRK09692 266835008723 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 266835008724 active site 266835008725 Int/Topo IB signature motif; other site 266835008726 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 266835008727 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 266835008728 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 266835008729 cyclase homology domain; Region: CHD; cd07302 266835008730 nucleotidyl binding site; other site 266835008731 metal binding site [ion binding]; metal-binding site 266835008732 dimer interface [polypeptide binding]; other site 266835008733 TolB amino-terminal domain; Region: TolB_N; cl00639 266835008734 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835008735 binding surface 266835008736 TPR motif; other site 266835008737 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835008738 binding surface 266835008739 TPR motif; other site 266835008740 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 266835008741 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266835008742 ATP binding site [chemical binding]; other site 266835008743 putative Mg++ binding site [ion binding]; other site 266835008744 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266835008745 nucleotide binding region [chemical binding]; other site 266835008746 ATP-binding site [chemical binding]; other site 266835008747 RQC domain; Region: RQC; cl09632 266835008748 HRDC domain; Region: HRDC; cl02578 266835008749 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 266835008750 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 266835008751 NAD(P) binding site [chemical binding]; other site 266835008752 catalytic residues [active] 266835008753 Cupin domain; Region: Cupin_2; cl09118 266835008754 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 266835008755 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835008756 NAD(P) binding site [chemical binding]; other site 266835008757 active site 266835008758 Glucuronate isomerase; Region: UxaC; cl00829 266835008759 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 266835008760 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 266835008761 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 266835008762 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 266835008763 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 266835008764 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 266835008765 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 266835008766 alpha subunit interaction interface [polypeptide binding]; other site 266835008767 Walker A motif; other site 266835008768 ATP binding site [chemical binding]; other site 266835008769 Walker B motif; other site 266835008770 inhibitor binding site; inhibition site 266835008771 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 266835008772 ATP synthase; Region: ATP-synt; cl00365 266835008773 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 266835008774 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 266835008775 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 266835008776 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 266835008777 beta subunit interaction interface [polypeptide binding]; other site 266835008778 Walker A motif; other site 266835008779 ATP binding site [chemical binding]; other site 266835008780 Walker B motif; other site 266835008781 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 266835008782 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl15360 266835008783 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 266835008784 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 266835008785 aspartate racemase; Region: asp_race; TIGR00035 266835008786 primosome assembly protein PriA; Validated; Region: PRK05580 266835008787 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266835008788 ATP binding site [chemical binding]; other site 266835008789 putative Mg++ binding site [ion binding]; other site 266835008790 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835008791 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 266835008792 active site 266835008793 intersubunit interactions; other site 266835008794 catalytic residue [active] 266835008795 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835008796 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 266835008797 Lipopolysaccharide-assembly; Region: LptE; cl01125 266835008798 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 266835008799 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 266835008800 HIGH motif; other site 266835008801 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266835008802 active site 266835008803 KMSKS motif; other site 266835008804 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 266835008805 tRNA binding surface [nucleotide binding]; other site 266835008806 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 266835008807 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266835008808 catalytic residue [active] 266835008809 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835008810 active site 266835008811 catalytic tetrad [active] 266835008812 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 266835008813 Helix-turn-helix domains; Region: HTH; cl00088 266835008814 transcriptional regulator; Provisional; Region: PRK10632 266835008815 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_10; cd08480 266835008816 putative effector binding pocket; other site 266835008817 putative dimerization interface [polypeptide binding]; other site 266835008818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835008819 putative substrate translocation pore; other site 266835008820 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 266835008821 active site 266835008822 catalytic triad [active] 266835008823 oxyanion hole [active] 266835008824 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 266835008825 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835008826 active site 266835008827 catalytic tetrad [active] 266835008828 Usg-like family; Region: Usg; cl11567 266835008829 acetyl-CoA synthetase; Provisional; Region: PRK00174 266835008830 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 266835008831 AMP-binding enzyme; Region: AMP-binding; cl15778 266835008832 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266835008833 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 266835008834 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 266835008835 MOSC domain; Region: MOSC; pfam03473 266835008836 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 266835008837 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835008838 S-adenosylmethionine binding site [chemical binding]; other site 266835008839 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 266835008840 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 266835008841 metal ion-dependent adhesion site (MIDAS); other site 266835008842 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 266835008843 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 266835008844 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 266835008845 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266835008846 Peptidase family M48; Region: Peptidase_M48; cl12018 266835008847 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 266835008848 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 266835008849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835008850 S-adenosylmethionine binding site [chemical binding]; other site 266835008851 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 266835008852 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 266835008853 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 266835008854 purine monophosphate binding site [chemical binding]; other site 266835008855 dimer interface [polypeptide binding]; other site 266835008856 putative catalytic residues [active] 266835008857 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 266835008858 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 266835008859 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 266835008860 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 266835008861 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 266835008862 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266835008863 YCII-related domain; Region: YCII; cl00999 266835008864 LysE type translocator; Region: LysE; cl00565 266835008865 Phosphoesterase family; Region: Phosphoesterase; cl15450 266835008866 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 266835008867 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 266835008868 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 266835008869 G1 box; other site 266835008870 putative GEF interaction site [polypeptide binding]; other site 266835008871 GTP/Mg2+ binding site [chemical binding]; other site 266835008872 Switch I region; other site 266835008873 G2 box; other site 266835008874 G3 box; other site 266835008875 Switch II region; other site 266835008876 G4 box; other site 266835008877 G5 box; other site 266835008878 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 266835008879 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 266835008880 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 266835008881 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 266835008882 putative active site [active] 266835008883 putative metal binding site [ion binding]; other site 266835008884 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266835008885 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266835008886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835008887 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835008888 putative substrate translocation pore; other site 266835008889 Helix-turn-helix domains; Region: HTH; cl00088 266835008890 DUF based on E. rectale Gene description; Region: DUF3879; pfam12995 266835008891 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 266835008892 dimer interface [polypeptide binding]; other site 266835008893 substrate binding site [chemical binding]; other site 266835008894 metal binding sites [ion binding]; metal-binding site 266835008895 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835008896 Domain of unknown function (DUF477); Region: DUF477; cl01535 266835008897 Domain of unknown function (DUF477); Region: DUF477; cl01535 266835008898 Domain of unknown function (DUF477); Region: DUF477; cl01535 266835008899 LemA family; Region: LemA; cl00742 266835008900 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 266835008901 pyridoxal binding site [chemical binding]; other site 266835008902 dimer interface [polypeptide binding]; other site 266835008903 ATP binding site [chemical binding]; other site 266835008904 Protein of unknown function (DUF429); Region: DUF429; cl12046 266835008905 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 266835008906 active site clefts [active] 266835008907 zinc binding site [ion binding]; other site 266835008908 dimer interface [polypeptide binding]; other site 266835008909 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 266835008910 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 266835008911 active site 266835008912 Zn binding site [ion binding]; other site 266835008913 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835008914 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835008915 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835008916 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835008917 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835008918 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835008919 Uncharacterized conserved protein [Function unknown]; Region: COG5476 266835008920 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 266835008921 MlrC C-terminus; Region: MlrC_C; pfam07171 266835008922 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835008923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835008924 dimer interface [polypeptide binding]; other site 266835008925 conserved gate region; other site 266835008926 ABC-ATPase subunit interface; other site 266835008927 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835008928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835008929 conserved gate region; other site 266835008930 dimer interface [polypeptide binding]; other site 266835008931 putative PBP binding loops; other site 266835008932 ABC-ATPase subunit interface; other site 266835008933 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835008934 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835008935 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835008936 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 266835008937 NAD(P) binding site [chemical binding]; other site 266835008938 active site 266835008939 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266835008940 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 266835008941 Walker A/P-loop; other site 266835008942 ATP binding site [chemical binding]; other site 266835008943 Q-loop/lid; other site 266835008944 ABC transporter signature motif; other site 266835008945 Walker B; other site 266835008946 D-loop; other site 266835008947 H-loop/switch region; other site 266835008948 TOBE domain; Region: TOBE_2; cl01440 266835008949 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266835008950 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266835008951 putative active site [active] 266835008952 Uncharacterised ACR, YggU family COG1872; Region: DUF167; cl00811 266835008953 Helix-turn-helix domains; Region: HTH; cl00088 266835008954 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 266835008955 NADPH bind site [chemical binding]; other site 266835008956 putative FMN binding site [chemical binding]; other site 266835008957 Gram-negative bacterial tonB protein; Region: TonB; cl10048 266835008958 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 266835008959 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 266835008960 Isochorismatase family; Region: Isochorismatase; pfam00857 266835008961 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 266835008962 catalytic triad [active] 266835008963 conserved cis-peptide bond; other site 266835008964 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 266835008965 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266835008966 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266835008967 classical (c) SDRs; Region: SDR_c; cd05233 266835008968 NAD(P) binding site [chemical binding]; other site 266835008969 active site 266835008970 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266835008971 TM-ABC transporter signature motif; other site 266835008972 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266835008973 TM-ABC transporter signature motif; other site 266835008974 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 266835008975 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 266835008976 Walker A/P-loop; other site 266835008977 ATP binding site [chemical binding]; other site 266835008978 Q-loop/lid; other site 266835008979 ABC transporter signature motif; other site 266835008980 Walker B; other site 266835008981 D-loop; other site 266835008982 H-loop/switch region; other site 266835008983 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 266835008984 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 266835008985 putative ligand binding site [chemical binding]; other site 266835008986 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 266835008987 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266835008988 dimer interface [polypeptide binding]; other site 266835008989 active site 266835008990 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 266835008991 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 266835008992 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 266835008993 Helix-turn-helix domains; Region: HTH; cl00088 266835008994 Bacterial transcriptional regulator; Region: IclR; pfam01614 266835008995 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835008996 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835008997 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 266835008998 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266835008999 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 266835009000 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 266835009001 homodimer interface [polypeptide binding]; other site 266835009002 active site 266835009003 TDP-binding site; other site 266835009004 acceptor substrate-binding pocket; other site 266835009005 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835009006 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835009007 DNA-binding site [nucleotide binding]; DNA binding site 266835009008 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835009009 FCD domain; Region: FCD; cl11656 266835009010 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835009011 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835009012 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835009013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835009014 putative PBP binding loops; other site 266835009015 ABC-ATPase subunit interface; other site 266835009016 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835009017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835009018 dimer interface [polypeptide binding]; other site 266835009019 conserved gate region; other site 266835009020 putative PBP binding loops; other site 266835009021 ABC-ATPase subunit interface; other site 266835009022 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835009023 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835009024 Walker A/P-loop; other site 266835009025 ATP binding site [chemical binding]; other site 266835009026 Q-loop/lid; other site 266835009027 ABC transporter signature motif; other site 266835009028 Walker B; other site 266835009029 D-loop; other site 266835009030 H-loop/switch region; other site 266835009031 TOBE domain; Region: TOBE_2; cl01440 266835009032 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 266835009033 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 266835009034 active site 266835009035 TDP-binding site; other site 266835009036 acceptor substrate-binding pocket; other site 266835009037 homodimer interface [polypeptide binding]; other site 266835009038 Cupin domain; Region: Cupin_2; cl09118 266835009039 Cupin domain; Region: Cupin_2; cl09118 266835009040 Cupin domain; Region: Cupin_2; cl09118 266835009041 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835009042 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266835009043 NAD(P) binding site [chemical binding]; other site 266835009044 catalytic residues [active] 266835009045 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 266835009046 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835009047 substrate binding site [chemical binding]; other site 266835009048 oxyanion hole (OAH) forming residues; other site 266835009049 trimer interface [polypeptide binding]; other site 266835009050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835009051 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266835009052 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266835009053 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835009054 TM-ABC transporter signature motif; other site 266835009055 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835009056 TM-ABC transporter signature motif; other site 266835009057 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835009058 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 266835009059 Walker A/P-loop; other site 266835009060 ATP binding site [chemical binding]; other site 266835009061 Q-loop/lid; other site 266835009062 ABC transporter signature motif; other site 266835009063 Walker B; other site 266835009064 D-loop; other site 266835009065 H-loop/switch region; other site 266835009066 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 266835009067 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 266835009068 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266835009069 putative ligand binding site [chemical binding]; other site 266835009070 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 266835009071 Domain interface; other site 266835009072 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 266835009073 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 266835009074 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 266835009075 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835009076 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 266835009077 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 266835009078 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 266835009079 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 266835009080 Predicted transcriptional regulator [Transcription]; Region: COG4957 266835009081 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 266835009082 transaminase; Validated; Region: PRK07324 266835009083 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835009084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835009085 homodimer interface [polypeptide binding]; other site 266835009086 catalytic residue [active] 266835009087 enterobactin exporter EntS; Provisional; Region: PRK10489 266835009088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835009089 putative substrate translocation pore; other site 266835009090 NIPSNAP; Region: NIPSNAP; pfam07978 266835009091 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 266835009092 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 266835009093 catalytic triad [active] 266835009094 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 266835009095 putative metal binding site [ion binding]; other site 266835009096 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 266835009097 HemY protein N-terminus; Region: HemY_N; pfam07219 266835009098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 266835009099 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 266835009100 active site 266835009101 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 266835009102 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 266835009103 domain interfaces; other site 266835009104 active site 266835009105 UGMP family protein; Validated; Region: PRK09604 266835009106 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 266835009107 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835009108 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 266835009109 YCII-related domain; Region: YCII; cl00999 266835009110 EVE domain; Region: EVE; cl00728 266835009111 Predicted methyltransferase [General function prediction only]; Region: COG3897 266835009112 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835009113 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 266835009114 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266835009115 Helix-turn-helix domains; Region: HTH; cl00088 266835009116 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266835009117 dimerization interface [polypeptide binding]; other site 266835009118 substrate binding pocket [chemical binding]; other site 266835009119 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 266835009120 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835009121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835009122 active site 266835009123 phosphorylation site [posttranslational modification] 266835009124 intermolecular recognition site; other site 266835009125 dimerization interface [polypeptide binding]; other site 266835009126 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835009127 DNA binding site [nucleotide binding] 266835009128 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266835009129 ligand binding site [chemical binding]; other site 266835009130 flexible hinge region; other site 266835009131 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 266835009132 putative phosphate binding site [ion binding]; other site 266835009133 putative catalytic site [active] 266835009134 active site 266835009135 metal binding site A [ion binding]; metal-binding site 266835009136 DNA binding site [nucleotide binding] 266835009137 putative AP binding site [nucleotide binding]; other site 266835009138 putative metal binding site B [ion binding]; other site 266835009139 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 266835009140 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 266835009141 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835009142 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 266835009143 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 266835009144 Nitrogen regulatory protein P-II; Region: P-II; cl00412 266835009145 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 266835009146 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 266835009147 active site 266835009148 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 266835009149 catalytic triad [active] 266835009150 dimer interface [polypeptide binding]; other site 266835009151 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 266835009152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835009153 YCII-related domain; Region: YCII; cl00999 266835009154 OsmC-like protein; Region: OsmC; cl00767 266835009155 Protein of unknown function, DUF480; Region: DUF480; cl01209 266835009156 hypothetical protein; Provisional; Region: PRK11239 266835009157 Sulfatase; Region: Sulfatase; cl10460 266835009158 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 266835009159 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 266835009160 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 266835009161 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 266835009162 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835009163 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 266835009164 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 266835009165 putative SdhC subunit interface [polypeptide binding]; other site 266835009166 putative proximal heme binding site [chemical binding]; other site 266835009167 putative Iron-sulfur protein interface [polypeptide binding]; other site 266835009168 putative proximal quinone binding site; other site 266835009169 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 266835009170 Iron-sulfur protein interface; other site 266835009171 proximal quinone binding site [chemical binding]; other site 266835009172 SdhD (CybS) interface [polypeptide binding]; other site 266835009173 proximal heme binding site [chemical binding]; other site 266835009174 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835009175 metal binding site [ion binding]; metal-binding site 266835009176 active site 266835009177 I-site; other site 266835009178 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835009179 metal binding site [ion binding]; metal-binding site 266835009180 active site 266835009181 I-site; other site 266835009182 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 266835009183 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 266835009184 substrate binding site [chemical binding]; other site 266835009185 ligand binding site [chemical binding]; other site 266835009186 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835009187 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835009188 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835009189 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835009190 S-adenosylmethionine binding site [chemical binding]; other site 266835009191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835009192 dimer interface [polypeptide binding]; other site 266835009193 conserved gate region; other site 266835009194 putative PBP binding loops; other site 266835009195 ABC-ATPase subunit interface; other site 266835009196 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266835009197 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835009198 substrate binding pocket [chemical binding]; other site 266835009199 membrane-bound complex binding site; other site 266835009200 hinge residues; other site 266835009201 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266835009202 Helix-turn-helix domains; Region: HTH; cl00088 266835009203 OsmC-like protein; Region: OsmC; cl00767 266835009204 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 266835009205 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 266835009206 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266835009207 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 266835009208 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 266835009209 RimM N-terminal domain; Region: RimM; pfam01782 266835009210 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 266835009211 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 266835009212 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266835009213 DNA binding site [nucleotide binding] 266835009214 Int/Topo IB signature motif; other site 266835009215 active site 266835009216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 266835009217 TraB family; Region: TraB; cl12050 266835009218 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 266835009219 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 266835009220 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835009221 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266835009222 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266835009223 short chain dehydrogenase; Provisional; Region: PRK06123 266835009224 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835009225 NAD(P) binding site [chemical binding]; other site 266835009226 active site 266835009227 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 266835009228 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266835009229 E3 interaction surface; other site 266835009230 lipoyl attachment site [posttranslational modification]; other site 266835009231 e3 binding domain; Region: E3_binding; pfam02817 266835009232 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 266835009233 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 266835009234 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 266835009235 TPP-binding site [chemical binding]; other site 266835009236 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 266835009237 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 266835009238 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835009239 CoA-ligase; Region: Ligase_CoA; cl02894 266835009240 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 266835009241 Cupin domain; Region: Cupin_2; cl09118 266835009242 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 266835009243 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 266835009244 CoA-ligase; Region: Ligase_CoA; pfam00549 266835009245 malate dehydrogenase; Reviewed; Region: PRK06223 266835009246 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 266835009247 NAD(P) binding site [chemical binding]; other site 266835009248 dimer interface [polypeptide binding]; other site 266835009249 tetramer (dimer of dimers) interface [polypeptide binding]; other site 266835009250 substrate binding site [chemical binding]; other site 266835009251 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 266835009252 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835009253 Coenzyme A binding pocket [chemical binding]; other site 266835009254 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 266835009255 Protease inhibitor Inh; Region: Inh; pfam02974 266835009256 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266835009257 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 266835009258 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 266835009259 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 266835009260 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 266835009261 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 266835009262 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 266835009263 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 266835009264 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835009265 Intracellular septation protein A; Region: IspA; cl01098 266835009266 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 266835009267 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 266835009268 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 266835009269 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 266835009270 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 266835009271 catalytic residues [active] 266835009272 central insert; other site 266835009273 Heme exporter protein D (CcmD); Region: CcmD; cl11475 266835009274 CcmB protein; Region: CcmB; cl01016 266835009275 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 266835009276 CcmA, the ATP-binding component of the bacterial CcmAB transporter. The CCM family is involved in bacterial cytochrome c biogenesis. Cytochrome c maturation in E. coli requires the ccm operon, which encodes eight membrane proteins (CcmABCDEFGH). CcmE...; Region: ABC_CcmA_heme_exporter; cd03231 266835009277 Walker A/P-loop; other site 266835009278 ATP binding site [chemical binding]; other site 266835009279 Q-loop/lid; other site 266835009280 ABC transporter signature motif; other site 266835009281 Walker B; other site 266835009282 D-loop; other site 266835009283 H-loop/switch region; other site 266835009284 aconitate hydratase; Validated; Region: PRK09277 266835009285 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 266835009286 substrate binding site [chemical binding]; other site 266835009287 ligand binding site [chemical binding]; other site 266835009288 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 266835009289 substrate binding site [chemical binding]; other site 266835009290 Ceramidase; Region: Ceramidase; pfam05875 266835009291 Protein of unknown function (DUF1223); Region: DUF1223; cl10501 266835009292 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 266835009293 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 266835009294 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835009295 Coenzyme A binding pocket [chemical binding]; other site 266835009296 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 266835009297 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 266835009298 FtsX-like permease family; Region: FtsX; cl15850 266835009299 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 266835009300 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 266835009301 Walker A/P-loop; other site 266835009302 ATP binding site [chemical binding]; other site 266835009303 Q-loop/lid; other site 266835009304 ABC transporter signature motif; other site 266835009305 Walker B; other site 266835009306 D-loop; other site 266835009307 H-loop/switch region; other site 266835009308 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 266835009309 active site 266835009310 catalytic triad [active] 266835009311 oxyanion hole [active] 266835009312 switch loop; other site 266835009313 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 266835009314 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 266835009315 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 266835009316 Low molecular weight phosphatase family; Region: LMWPc; cd00115 266835009317 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 266835009318 active site 266835009319 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 266835009320 aromatic arch; other site 266835009321 DCoH dimer interaction site [polypeptide binding]; other site 266835009322 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 266835009323 DCoH tetramer interaction site [polypeptide binding]; other site 266835009324 substrate binding site [chemical binding]; other site 266835009325 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 266835009326 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 266835009327 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 266835009328 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 266835009329 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 266835009330 putative ion selectivity filter; other site 266835009331 putative pore gating glutamate residue; other site 266835009332 putative H+/Cl- coupling transport residue; other site 266835009333 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 266835009334 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835009335 FeS/SAM binding site; other site 266835009336 LysE type translocator; Region: LysE; cl00565 266835009337 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 266835009338 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 266835009339 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 266835009340 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 266835009341 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835009342 metal binding site [ion binding]; metal-binding site 266835009343 active site 266835009344 I-site; other site 266835009345 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835009346 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 266835009347 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 266835009348 ANP binding site [chemical binding]; other site 266835009349 Substrate Binding Site II [chemical binding]; other site 266835009350 Substrate Binding Site I [chemical binding]; other site 266835009351 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 266835009352 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 266835009353 Bacterial SH3 domain; Region: SH3_3; cl02551 266835009354 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 266835009355 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 266835009356 signal recognition particle protein; Provisional; Region: PRK10867 266835009357 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 266835009358 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 266835009359 P loop; other site 266835009360 GTP binding site [chemical binding]; other site 266835009361 Signal peptide binding domain; Region: SRP_SPB; pfam02978 266835009362 Chorismate mutase type II; Region: CM_2; cl00693 266835009363 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 266835009364 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266835009365 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835009366 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 266835009367 putative hydrophobic ligand binding site [chemical binding]; other site 266835009368 DoxX; Region: DoxX; cl00976 266835009369 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 266835009370 ACT domain; Region: ACT_3; cl01447 266835009371 Uncharacterized conserved protein [Function unknown]; Region: COG3603 266835009372 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835009373 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 266835009374 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835009375 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 266835009376 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 266835009377 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835009378 ATP binding site [chemical binding]; other site 266835009379 putative Mg++ binding site [ion binding]; other site 266835009380 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266835009381 nucleotide binding region [chemical binding]; other site 266835009382 ATP-binding site [chemical binding]; other site 266835009383 DbpA RNA binding domain; Region: DbpA; pfam03880 266835009384 Protein of unknown function (DUF805); Region: DUF805; cl01224 266835009385 Protein of unknown function (DUF805); Region: DUF805; cl01224 266835009386 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 266835009387 hydrophobic ligand binding site; other site 266835009388 Helix-turn-helix domains; Region: HTH; cl00088 266835009389 tartrate dehydrogenase; Provisional; Region: PRK08194 266835009390 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 266835009391 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 266835009392 dimer interface [polypeptide binding]; other site 266835009393 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835009394 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 266835009395 homotrimer interaction site [polypeptide binding]; other site 266835009396 putative active site [active] 266835009397 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 266835009398 substrate binding site [chemical binding]; other site 266835009399 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835009400 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835009401 dimerization interface [polypeptide binding]; other site 266835009402 putative DNA binding site [nucleotide binding]; other site 266835009403 putative Zn2+ binding site [ion binding]; other site 266835009404 Protein of unknown function DUF72; Region: DUF72; cl00777 266835009405 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835009406 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266835009407 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835009408 dimer interface [polypeptide binding]; other site 266835009409 phosphorylation site [posttranslational modification] 266835009410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835009411 ATP binding site [chemical binding]; other site 266835009412 Mg2+ binding site [ion binding]; other site 266835009413 G-X-G motif; other site 266835009414 DNA-binding response regulator CreB; Provisional; Region: PRK11083 266835009415 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835009416 active site 266835009417 phosphorylation site [posttranslational modification] 266835009418 intermolecular recognition site; other site 266835009419 dimerization interface [polypeptide binding]; other site 266835009420 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835009421 DNA binding site [nucleotide binding] 266835009422 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 266835009423 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 266835009424 Domain of unknown function (DUF1737); Region: DUF1737; cl10503 266835009425 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 266835009426 GIY-YIG motif/motif A; other site 266835009427 putative active site [active] 266835009428 putative metal binding site [ion binding]; other site 266835009429 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 266835009430 Cell division inhibitor SulA; Region: SulA; cl01880 266835009431 DNA Polymerase Y-family; Region: PolY_like; cd03468 266835009432 active site 266835009433 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 266835009434 DNA binding site [nucleotide binding] 266835009435 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 266835009436 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 266835009437 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 266835009438 generic binding surface I; other site 266835009439 generic binding surface II; other site 266835009440 Trm112p-like protein; Region: Trm112p; cl01066 266835009441 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 266835009442 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 266835009443 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 266835009444 catalytic residues [active] 266835009445 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 266835009446 putative deacylase active site [active] 266835009447 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835009448 Helix-turn-helix domains; Region: HTH; cl00088 266835009449 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 266835009450 substrate binding pocket [chemical binding]; other site 266835009451 dimerization interface [polypeptide binding]; other site 266835009452 Epoxide hydrolase N terminus; Region: EHN; pfam06441 266835009453 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835009454 SapC; Region: SapC; pfam07277 266835009455 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 266835009456 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835009457 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 266835009458 Phage Tail Collar Domain; Region: Collar; pfam07484 266835009459 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 266835009460 Phage Tail Collar Domain; Region: Collar; pfam07484 266835009461 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 266835009462 Phage Tail Collar Domain; Region: Collar; pfam07484 266835009463 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 266835009464 autotransport protein MisL; Provisional; Region: PRK15313 266835009465 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 266835009466 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 266835009467 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266835009468 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266835009469 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266835009470 active site 266835009471 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266835009472 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835009473 Predicted amidohydrolase [General function prediction only]; Region: COG3964 266835009474 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266835009475 active site 266835009476 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266835009477 homotrimer interaction site [polypeptide binding]; other site 266835009478 putative active site [active] 266835009479 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 266835009480 Phospholipid methyltransferase; Region: PEMT; cl00763 266835009481 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 266835009482 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266835009483 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266835009484 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266835009485 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266835009486 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 266835009487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835009488 active site 266835009489 phosphorylation site [posttranslational modification] 266835009490 intermolecular recognition site; other site 266835009491 dimerization interface [polypeptide binding]; other site 266835009492 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835009493 DNA binding site [nucleotide binding] 266835009494 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 266835009495 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835009496 dimer interface [polypeptide binding]; other site 266835009497 phosphorylation site [posttranslational modification] 266835009498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835009499 ATP binding site [chemical binding]; other site 266835009500 Mg2+ binding site [ion binding]; other site 266835009501 G-X-G motif; other site 266835009502 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 266835009503 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 266835009504 Walker A/P-loop; other site 266835009505 ATP binding site [chemical binding]; other site 266835009506 Q-loop/lid; other site 266835009507 ABC transporter signature motif; other site 266835009508 Walker B; other site 266835009509 D-loop; other site 266835009510 H-loop/switch region; other site 266835009511 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 266835009512 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 266835009513 Walker A/P-loop; other site 266835009514 ATP binding site [chemical binding]; other site 266835009515 Q-loop/lid; other site 266835009516 ABC transporter signature motif; other site 266835009517 Walker B; other site 266835009518 D-loop; other site 266835009519 H-loop/switch region; other site 266835009520 FtsX-like permease family; Region: FtsX; cl15850 266835009521 Protein of unknown function (DUF1344); Region: DUF1344; pfam07076 266835009522 Helix-turn-helix domains; Region: HTH; cl00088 266835009523 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 266835009524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835009525 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 266835009526 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835009527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835009528 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266835009529 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 266835009530 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266835009531 E3 interaction surface; other site 266835009532 lipoyl attachment site [posttranslational modification]; other site 266835009533 e3 binding domain; Region: E3_binding; pfam02817 266835009534 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 266835009535 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 266835009536 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 266835009537 alpha subunit interface [polypeptide binding]; other site 266835009538 TPP binding site [chemical binding]; other site 266835009539 heterodimer interface [polypeptide binding]; other site 266835009540 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266835009541 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 266835009542 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 266835009543 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 266835009544 tetramer interface [polypeptide binding]; other site 266835009545 TPP-binding site [chemical binding]; other site 266835009546 heterodimer interface [polypeptide binding]; other site 266835009547 phosphorylation loop region [posttranslational modification] 266835009548 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 266835009549 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 266835009550 Protein of unknown function (DUF1326); Region: DUF1326; cl02375 266835009551 ParB-like nuclease domain; Region: ParBc; cl02129 266835009552 ParB-like partition proteins; Region: parB_part; TIGR00180 266835009553 KorB domain; Region: KorB; pfam08535 266835009554 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 266835009555 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266835009556 P-loop; other site 266835009557 Magnesium ion binding site [ion binding]; other site 266835009558 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266835009559 Magnesium ion binding site [ion binding]; other site 266835009560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 266835009561 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 266835009562 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 266835009563 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 266835009564 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 266835009565 trmE is a tRNA modification GTPase; Region: trmE; cd04164 266835009566 G1 box; other site 266835009567 GTP/Mg2+ binding site [chemical binding]; other site 266835009568 Switch I region; other site 266835009569 G2 box; other site 266835009570 Switch II region; other site 266835009571 G3 box; other site 266835009572 G4 box; other site 266835009573 G5 box; other site 266835009574 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 266835009575 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 266835009576 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 266835009577 catalytic residues [active] 266835009578 transcription termination factor Rho; Provisional; Region: rho; PRK09376 266835009579 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 266835009580 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 266835009581 RNA binding site [nucleotide binding]; other site 266835009582 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 266835009583 multimer interface [polypeptide binding]; other site 266835009584 Walker A motif; other site 266835009585 ATP binding site [chemical binding]; other site 266835009586 Walker B motif; other site 266835009587 Uncharacterised protein family (UPF0093); Region: UPF0093; cl00863 266835009588 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 266835009589 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 266835009590 substrate binding site [chemical binding]; other site 266835009591 active site 266835009592 Domain of unknown function (DUF299); Region: DUF299; cl00780 266835009593 Maf-like protein; Region: Maf; pfam02545 266835009594 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 266835009595 active site 266835009596 dimer interface [polypeptide binding]; other site 266835009597 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 266835009598 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 266835009599 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 266835009600 shikimate binding site; other site 266835009601 NAD(P) binding site [chemical binding]; other site 266835009602 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 266835009603 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 266835009604 CoA-binding site [chemical binding]; other site 266835009605 ATP-binding [chemical binding]; other site 266835009606 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 266835009607 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 266835009608 active site 266835009609 substrate binding site [chemical binding]; other site 266835009610 catalytic site [active] 266835009611 acetyl esterase; Provisional; Region: PRK10162 266835009612 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266835009613 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015 266835009614 Isochorismatase family; Region: Isochorismatase; pfam00857 266835009615 substrate binding site [chemical binding]; other site 266835009616 catalytic triad [active] 266835009617 domain interfaces; other site 266835009618 conserved cis-peptide bond; other site 266835009619 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266835009620 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266835009621 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266835009622 active site 266835009623 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266835009624 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 266835009625 conserved cys residue [active] 266835009626 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835009627 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 266835009628 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 266835009629 homodimer interface [polypeptide binding]; other site 266835009630 substrate-cofactor binding pocket; other site 266835009631 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835009632 catalytic residue [active] 266835009633 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 266835009634 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 266835009635 dimer interface [polypeptide binding]; other site 266835009636 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835009637 catalytic residue [active] 266835009638 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 266835009639 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266835009640 homotrimer interaction site [polypeptide binding]; other site 266835009641 putative active site [active] 266835009642 Isochorismatase family; Region: Isochorismatase; pfam00857 266835009643 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 266835009644 catalytic triad [active] 266835009645 conserved cis-peptide bond; other site 266835009646 Helix-turn-helix domains; Region: HTH; cl00088 266835009647 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 266835009648 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 266835009649 potential catalytic triad [active] 266835009650 conserved cys residue [active] 266835009651 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 266835009652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835009653 Predicted transcriptional regulator [Transcription]; Region: COG1959 266835009654 Helix-turn-helix domains; Region: HTH; cl00088 266835009655 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 266835009656 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 266835009657 ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525 266835009658 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 266835009659 Walker A/P-loop; other site 266835009660 ATP binding site [chemical binding]; other site 266835009661 Q-loop/lid; other site 266835009662 ABC transporter signature motif; other site 266835009663 Walker B; other site 266835009664 D-loop; other site 266835009665 H-loop/switch region; other site 266835009666 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266835009667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835009668 dimer interface [polypeptide binding]; other site 266835009669 conserved gate region; other site 266835009670 putative PBP binding loops; other site 266835009671 ABC-ATPase subunit interface; other site 266835009672 ABC-2 type transporter; Region: ABC2_membrane; cl11417 266835009673 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 266835009674 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 266835009675 Walker A/P-loop; other site 266835009676 ATP binding site [chemical binding]; other site 266835009677 Q-loop/lid; other site 266835009678 ABC transporter signature motif; other site 266835009679 Walker B; other site 266835009680 D-loop; other site 266835009681 H-loop/switch region; other site 266835009682 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 266835009683 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 266835009684 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 266835009685 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 266835009686 Predicted ATPase [General function prediction only]; Region: COG3899 266835009687 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835009688 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835009689 DNA binding residues [nucleotide binding] 266835009690 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 266835009691 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 266835009692 Protein of unknown function (DUF1223); Region: DUF1223; cl10501 266835009693 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 266835009694 TadE-like protein; Region: TadE; cl10688 266835009695 GTP-binding protein LepA; Provisional; Region: PRK05433 266835009696 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 266835009697 G1 box; other site 266835009698 putative GEF interaction site [polypeptide binding]; other site 266835009699 GTP/Mg2+ binding site [chemical binding]; other site 266835009700 Switch I region; other site 266835009701 G2 box; other site 266835009702 G3 box; other site 266835009703 Switch II region; other site 266835009704 G4 box; other site 266835009705 G5 box; other site 266835009706 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 266835009707 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 266835009708 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 266835009709 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835009710 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 266835009711 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 266835009712 SecA binding site; other site 266835009713 Preprotein binding site; other site 266835009714 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 266835009715 Tim44-like domain; Region: Tim44; cl09208 266835009716 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 266835009717 MltA specific insert domain; Region: MltA; cl08398 266835009718 3D domain; Region: 3D; cl01439 266835009719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 266835009720 Smr domain; Region: Smr; cl02619 266835009721 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835009722 non-specific DNA binding site [nucleotide binding]; other site 266835009723 salt bridge; other site 266835009724 sequence-specific DNA binding site [nucleotide binding]; other site 266835009725 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 266835009726 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 266835009727 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 266835009728 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 266835009729 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266835009730 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 266835009731 Walker A/P-loop; other site 266835009732 ATP binding site [chemical binding]; other site 266835009733 Q-loop/lid; other site 266835009734 ABC transporter signature motif; other site 266835009735 Walker B; other site 266835009736 D-loop; other site 266835009737 H-loop/switch region; other site 266835009738 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266835009739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835009740 dimer interface [polypeptide binding]; other site 266835009741 conserved gate region; other site 266835009742 ABC-ATPase subunit interface; other site 266835009743 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 266835009744 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 266835009745 active site 266835009746 dimer interface [polypeptide binding]; other site 266835009747 non-prolyl cis peptide bond; other site 266835009748 insertion regions; other site 266835009749 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 266835009750 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835009751 substrate binding pocket [chemical binding]; other site 266835009752 NMT1-like family; Region: NMT1_2; cl15260 266835009753 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 266835009754 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266835009755 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835009756 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 266835009757 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266835009758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835009759 active site 266835009760 phosphorylation site [posttranslational modification] 266835009761 intermolecular recognition site; other site 266835009762 dimerization interface [polypeptide binding]; other site 266835009763 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835009764 DNA binding residues [nucleotide binding] 266835009765 dimerization interface [polypeptide binding]; other site 266835009766 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 266835009767 Histidine kinase; Region: HisKA_3; pfam07730 266835009768 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835009769 ATP binding site [chemical binding]; other site 266835009770 Mg2+ binding site [ion binding]; other site 266835009771 G-X-G motif; other site 266835009772 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 266835009773 active site 266835009774 Helix-turn-helix domains; Region: HTH; cl00088 266835009775 putative transporter; Provisional; Region: PRK11660 266835009776 Permease family; Region: Xan_ur_permease; cl00967 266835009777 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 266835009778 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 266835009779 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266835009780 EamA-like transporter family; Region: EamA; cl01037 266835009781 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 266835009782 EamA-like transporter family; Region: EamA; cl01037 266835009783 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 266835009784 Helix-turn-helix domains; Region: HTH; cl00088 266835009785 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835009786 dimerization interface [polypeptide binding]; other site 266835009787 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 266835009788 active site 266835009789 DNA binding site [nucleotide binding] 266835009790 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266835009791 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 266835009792 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835009793 non-specific DNA binding site [nucleotide binding]; other site 266835009794 salt bridge; other site 266835009795 sequence-specific DNA binding site [nucleotide binding]; other site 266835009796 cyclase homology domain; Region: CHD; cd07302 266835009797 nucleotidyl binding site; other site 266835009798 metal binding site [ion binding]; metal-binding site 266835009799 dimer interface [polypeptide binding]; other site 266835009800 hypothetical protein; Provisional; Region: PRK11479 266835009801 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 266835009802 CHAD domain; Region: CHAD; cl10506 266835009803 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 266835009804 putative active site [active] 266835009805 putative metal binding residues [ion binding]; other site 266835009806 signature motif; other site 266835009807 putative dimer interface [polypeptide binding]; other site 266835009808 putative phosphate binding site [ion binding]; other site 266835009809 Helix-turn-helix domains; Region: HTH; cl00088 266835009810 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 266835009811 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 266835009812 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 266835009813 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 266835009814 Walker A/P-loop; other site 266835009815 ATP binding site [chemical binding]; other site 266835009816 Q-loop/lid; other site 266835009817 ABC transporter signature motif; other site 266835009818 Walker B; other site 266835009819 D-loop; other site 266835009820 H-loop/switch region; other site 266835009821 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 266835009822 ABC-2 type transporter; Region: ABC2_membrane; cl11417 266835009823 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 266835009824 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 266835009825 tetramer interface [polypeptide binding]; other site 266835009826 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835009827 catalytic residue [active] 266835009828 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 266835009829 diiron binding motif [ion binding]; other site 266835009830 Uncharacterized conserved protein [Function unknown]; Region: COG1633 266835009831 CCC1-related protein family; Region: CCC1_like_1; cd02437 266835009832 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 266835009833 NIPSNAP; Region: NIPSNAP; pfam07978 266835009834 Helix-turn-helix domains; Region: HTH; cl00088 266835009835 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 266835009836 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 266835009837 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 266835009838 active site 266835009839 DNA binding site [nucleotide binding] 266835009840 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 266835009841 DNA binding site [nucleotide binding] 266835009842 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 266835009843 nucleotide binding site [chemical binding]; other site 266835009844 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 266835009845 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 266835009846 putative DNA binding site [nucleotide binding]; other site 266835009847 putative homodimer interface [polypeptide binding]; other site 266835009848 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 266835009849 dimerization interface [polypeptide binding]; other site 266835009850 metal binding site [ion binding]; metal-binding site 266835009851 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266835009852 homotrimer interaction site [polypeptide binding]; other site 266835009853 putative active site [active] 266835009854 YCII-related domain; Region: YCII; cl00999 266835009855 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 266835009856 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 266835009857 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835009858 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 266835009859 C-terminal domain interface [polypeptide binding]; other site 266835009860 GSH binding site (G-site) [chemical binding]; other site 266835009861 dimer interface [polypeptide binding]; other site 266835009862 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 266835009863 dimer interface [polypeptide binding]; other site 266835009864 N-terminal domain interface [polypeptide binding]; other site 266835009865 substrate binding pocket (H-site) [chemical binding]; other site 266835009866 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 266835009867 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 266835009868 dimer interface [polypeptide binding]; other site 266835009869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835009870 catalytic residue [active] 266835009871 LysE type translocator; Region: LysE; cl00565 266835009872 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 266835009873 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 266835009874 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 266835009875 HrcA protein C terminal domain; Region: HrcA; pfam01628 266835009876 ribonuclease PH; Reviewed; Region: rph; PRK00173 266835009877 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 266835009878 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 266835009879 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 266835009880 putative metal binding site [ion binding]; other site 266835009881 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835009882 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 266835009883 active site 266835009884 dimerization interface [polypeptide binding]; other site 266835009885 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 266835009886 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835009887 FeS/SAM binding site; other site 266835009888 HemN C-terminal region; Region: HemN_C; pfam06969 266835009889 Low molecular weight phosphatase family; Region: LMWPc; cl00105 266835009890 Predicted methyltransferases [General function prediction only]; Region: COG0313 266835009891 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 266835009892 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 266835009893 Bacitracin resistance protein BacA; Region: BacA; cl00858 266835009894 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835009895 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 266835009896 C-terminal domain interface [polypeptide binding]; other site 266835009897 GSH binding site (G-site) [chemical binding]; other site 266835009898 dimer interface [polypeptide binding]; other site 266835009899 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 266835009900 N-terminal domain interface [polypeptide binding]; other site 266835009901 dimer interface [polypeptide binding]; other site 266835009902 substrate binding pocket (H-site) [chemical binding]; other site 266835009903 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 266835009904 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 266835009905 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835009906 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 266835009907 putative NAD(P) binding site [chemical binding]; other site 266835009908 Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538 266835009909 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 266835009910 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 266835009911 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266835009912 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 266835009913 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 266835009914 Walker A/P-loop; other site 266835009915 ATP binding site [chemical binding]; other site 266835009916 Q-loop/lid; other site 266835009917 ABC transporter signature motif; other site 266835009918 Walker B; other site 266835009919 D-loop; other site 266835009920 H-loop/switch region; other site 266835009921 dihydrodipicolinate reductase; Provisional; Region: PRK00048 266835009922 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835009923 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 266835009924 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266835009925 catalytic core [active] 266835009926 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 266835009927 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; cl09957 266835009928 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 266835009929 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 266835009930 TolB amino-terminal domain; Region: TolB_N; cl00639 266835009931 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835009932 binding surface 266835009933 TPR motif; other site 266835009934 TPR repeat; Region: TPR_11; pfam13414 266835009935 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 266835009936 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 266835009937 dimer interface [polypeptide binding]; other site 266835009938 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835009939 catalytic residue [active] 266835009940 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 266835009941 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 266835009942 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835009943 catalytic residue [active] 266835009944 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835009945 DNA binding site [nucleotide binding] 266835009946 TolB amino-terminal domain; Region: TolB_N; cl00639 266835009947 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 266835009948 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835009949 binding surface 266835009950 TPR motif; other site 266835009951 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 266835009952 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 266835009953 Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369 266835009954 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 266835009955 Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369 266835009956 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 266835009957 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 266835009958 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266835009959 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 266835009960 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 266835009961 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 266835009962 active site 266835009963 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 266835009964 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835009965 Helix-turn-helix domains; Region: HTH; cl00088 266835009966 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835009967 Walker A motif; other site 266835009968 ATP binding site [chemical binding]; other site 266835009969 Walker B motif; other site 266835009970 arginine finger; other site 266835009971 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 266835009972 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 266835009973 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 266835009974 catalytic residues [active] 266835009975 catalytic nucleophile [active] 266835009976 Recombinase; Region: Recombinase; pfam07508 266835009977 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 266835009978 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 266835009979 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266835009980 HSP70 interaction site [polypeptide binding]; other site 266835009981 OpgC protein; Region: OpgC_C; cl00792 266835009982 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 266835009983 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 266835009984 active site 266835009985 DNA polymerase; Provisional; Region: PHA02563 266835009986 Double zinc ribbon; Region: DZR; pfam12773 266835009987 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 266835009988 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835009989 dimerization interface [polypeptide binding]; other site 266835009990 putative DNA binding site [nucleotide binding]; other site 266835009991 putative Zn2+ binding site [ion binding]; other site 266835009992 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; cl11561 266835009993 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 266835009994 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266835009995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835009996 active site 266835009997 phosphorylation site [posttranslational modification] 266835009998 intermolecular recognition site; other site 266835009999 dimerization interface [polypeptide binding]; other site 266835010000 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835010001 DNA binding residues [nucleotide binding] 266835010002 dimerization interface [polypeptide binding]; other site 266835010003 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835010004 dimer interface [polypeptide binding]; other site 266835010005 phosphorylation site [posttranslational modification] 266835010006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835010007 ATP binding site [chemical binding]; other site 266835010008 Mg2+ binding site [ion binding]; other site 266835010009 G-X-G motif; other site 266835010010 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 266835010011 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 266835010012 Protein of unknown function (DUF768); Region: DUF768; pfam05589 266835010013 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 266835010014 trimer interface [polypeptide binding]; other site 266835010015 active site 266835010016 substrate binding site [chemical binding]; other site 266835010017 CoA binding site [chemical binding]; other site 266835010018 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 266835010019 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 266835010020 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 266835010021 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 266835010022 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 266835010023 catalytic residues [active] 266835010024 catalytic nucleophile [active] 266835010025 Presynaptic Site I dimer interface [polypeptide binding]; other site 266835010026 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 266835010027 Synaptic Flat tetramer interface [polypeptide binding]; other site 266835010028 Synaptic Site I dimer interface [polypeptide binding]; other site 266835010029 DNA binding site [nucleotide binding] 266835010030 Recombinase; Region: Recombinase; pfam07508 266835010031 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 266835010032 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 266835010033 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266835010034 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 266835010035 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 266835010036 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 266835010037 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 266835010038 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266835010039 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 266835010040 putative dimer interface [polypeptide binding]; other site 266835010041 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266835010042 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 266835010043 putative dimer interface [polypeptide binding]; other site 266835010044 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 266835010045 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 266835010046 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 266835010047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835010048 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 266835010049 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 266835010050 active site 266835010051 substrate binding site [chemical binding]; other site 266835010052 FMN binding site [chemical binding]; other site 266835010053 putative catalytic residues [active] 266835010054 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 266835010055 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835010056 glutathione synthetase; Provisional; Region: PRK05246 266835010057 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 266835010058 ATP-grasp domain; Region: ATP-grasp_4; cl03087 266835010059 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 266835010060 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 266835010061 Ligand binding site; other site 266835010062 Putative Catalytic site; other site 266835010063 DXD motif; other site 266835010064 GtrA-like protein; Region: GtrA; cl00971 266835010065 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835010066 metal binding site [ion binding]; metal-binding site 266835010067 active site 266835010068 I-site; other site 266835010069 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835010070 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 266835010071 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 266835010072 short chain dehydrogenase; Provisional; Region: PRK12939 266835010073 classical (c) SDRs; Region: SDR_c; cd05233 266835010074 NAD(P) binding site [chemical binding]; other site 266835010075 active site 266835010076 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 266835010077 active site 266835010078 intersubunit interface [polypeptide binding]; other site 266835010079 catalytic residue [active] 266835010080 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 266835010081 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 266835010082 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 266835010083 Cysteine dioxygenase type I; Region: CDO_I; cl15835 266835010084 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835010085 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835010086 DNA-binding site [nucleotide binding]; DNA binding site 266835010087 FCD domain; Region: FCD; cl11656 266835010088 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 266835010089 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 266835010090 active site 266835010091 dimer interface [polypeptide binding]; other site 266835010092 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 266835010093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835010094 S-adenosylmethionine binding site [chemical binding]; other site 266835010095 chaperone protein DnaJ; Provisional; Region: PRK10767 266835010096 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266835010097 HSP70 interaction site [polypeptide binding]; other site 266835010098 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 266835010099 substrate binding site [polypeptide binding]; other site 266835010100 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 266835010101 Zn binding sites [ion binding]; other site 266835010102 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 266835010103 dimer interface [polypeptide binding]; other site 266835010104 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 266835010105 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 266835010106 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 266835010107 substrate binding site [chemical binding]; other site 266835010108 hexamer interface [polypeptide binding]; other site 266835010109 metal binding site [ion binding]; metal-binding site 266835010110 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835010111 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835010112 DNA-binding site [nucleotide binding]; DNA binding site 266835010113 FCD domain; Region: FCD; cl11656 266835010114 malonyl-CoA synthase; Validated; Region: PRK07514 266835010115 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 266835010116 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 266835010117 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 266835010118 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 266835010119 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835010120 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 266835010121 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 266835010122 active site 266835010123 dimer interface [polypeptide binding]; other site 266835010124 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 266835010125 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 266835010126 dimer interface [polypeptide binding]; other site 266835010127 active site 266835010128 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 266835010129 dimer interface [polypeptide binding]; other site 266835010130 active site 266835010131 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 266835010132 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835010133 DNA-binding site [nucleotide binding]; DNA binding site 266835010134 UTRA domain; Region: UTRA; cl01230 266835010135 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 266835010136 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 266835010137 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 266835010138 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 266835010139 putative active site [active] 266835010140 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835010141 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835010142 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 266835010143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835010144 dimer interface [polypeptide binding]; other site 266835010145 conserved gate region; other site 266835010146 putative PBP binding loops; other site 266835010147 ABC-ATPase subunit interface; other site 266835010148 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835010149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835010150 dimer interface [polypeptide binding]; other site 266835010151 conserved gate region; other site 266835010152 putative PBP binding loops; other site 266835010153 ABC-ATPase subunit interface; other site 266835010154 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 266835010155 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835010156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835010157 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266835010158 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 266835010159 Walker A/P-loop; other site 266835010160 ATP binding site [chemical binding]; other site 266835010161 Q-loop/lid; other site 266835010162 ABC transporter signature motif; other site 266835010163 Walker B; other site 266835010164 D-loop; other site 266835010165 H-loop/switch region; other site 266835010166 TOBE domain; Region: TOBE_2; cl01440 266835010167 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266835010168 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 266835010169 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266835010170 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 266835010171 NAD binding site [chemical binding]; other site 266835010172 homotetramer interface [polypeptide binding]; other site 266835010173 homodimer interface [polypeptide binding]; other site 266835010174 active site 266835010175 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 266835010176 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835010177 NAD(P) binding site [chemical binding]; other site 266835010178 catalytic residues [active] 266835010179 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266835010180 NAD(P) binding site [chemical binding]; other site 266835010181 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 266835010182 intersubunit interface [polypeptide binding]; other site 266835010183 active site 266835010184 catalytic residue [active] 266835010185 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 266835010186 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 266835010187 FAD binding pocket [chemical binding]; other site 266835010188 FAD binding motif [chemical binding]; other site 266835010189 phosphate binding motif [ion binding]; other site 266835010190 beta-alpha-beta structure motif; other site 266835010191 NAD binding pocket [chemical binding]; other site 266835010192 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 266835010193 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266835010194 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 266835010195 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 266835010196 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835010197 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266835010198 substrate binding pocket [chemical binding]; other site 266835010199 membrane-bound complex binding site; other site 266835010200 hinge residues; other site 266835010201 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 266835010202 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 266835010203 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835010204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835010205 dimer interface [polypeptide binding]; other site 266835010206 conserved gate region; other site 266835010207 ABC-ATPase subunit interface; other site 266835010208 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 266835010209 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 266835010210 Walker A/P-loop; other site 266835010211 ATP binding site [chemical binding]; other site 266835010212 Q-loop/lid; other site 266835010213 ABC transporter signature motif; other site 266835010214 Walker B; other site 266835010215 D-loop; other site 266835010216 H-loop/switch region; other site 266835010217 NIL domain; Region: NIL; cl09633 266835010218 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 266835010219 Helix-turn-helix domains; Region: HTH; cl00088 266835010220 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835010221 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266835010222 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266835010223 Rhamnan synthesis protein F; Region: RgpF; cl01529 266835010224 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 266835010225 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 266835010226 Probable Catalytic site; other site 266835010227 metal-binding site 266835010228 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 266835010229 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 266835010230 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 266835010231 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835010232 Coenzyme A binding pocket [chemical binding]; other site 266835010233 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266835010234 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835010235 ATP binding site [chemical binding]; other site 266835010236 Mg2+ binding site [ion binding]; other site 266835010237 G-X-G motif; other site 266835010238 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 266835010239 Ribonuclease P; Region: Ribonuclease_P; cl00457 266835010240 membrane protein insertase; Provisional; Region: PRK01318 266835010241 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 266835010242 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 266835010243 Fasciclin domain; Region: Fasciclin; cl02663 266835010244 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 266835010245 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 266835010246 trimer interface [polypeptide binding]; other site 266835010247 active site 266835010248 substrate binding site [chemical binding]; other site 266835010249 CoA binding site [chemical binding]; other site 266835010250 Predicted GTPase [General function prediction only]; Region: COG0218 266835010251 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 266835010252 G1 box; other site 266835010253 GTP/Mg2+ binding site [chemical binding]; other site 266835010254 Switch I region; other site 266835010255 G2 box; other site 266835010256 G3 box; other site 266835010257 Switch II region; other site 266835010258 G4 box; other site 266835010259 G5 box; other site 266835010260 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835010261 Helix-turn-helix domains; Region: HTH; cl00088 266835010262 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 266835010263 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 266835010264 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266835010265 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266835010266 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266835010267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835010268 putative substrate translocation pore; other site 266835010269 SelR domain; Region: SelR; cl00369 266835010270 Fasciclin domain; Region: Fasciclin; cl02663 266835010271 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 266835010272 Anti-sigma-K factor rskA; Region: RskA; pfam10099 266835010273 RNA polymerase sigma factor; Provisional; Region: PRK12514 266835010274 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835010275 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 266835010276 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 266835010277 Amidase; Region: Amidase; cl11426 266835010278 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 266835010279 feedback inhibition sensing region; other site 266835010280 homohexameric interface [polypeptide binding]; other site 266835010281 nucleotide binding site [chemical binding]; other site 266835010282 N-acetyl-L-glutamate binding site [chemical binding]; other site 266835010283 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 266835010284 homotrimer interaction site [polypeptide binding]; other site 266835010285 putative active site [active] 266835010286 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 266835010287 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 266835010288 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835010289 FeS/SAM binding site; other site 266835010290 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835010291 Helix-turn-helix domains; Region: HTH; cl00088 266835010292 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 266835010293 cofactor binding site; other site 266835010294 metal binding site [ion binding]; metal-binding site 266835010295 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 266835010296 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835010297 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835010298 Helix-turn-helix domains; Region: HTH; cl00088 266835010299 Helix-turn-helix domains; Region: HTH; cl00088 266835010300 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835010301 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 266835010302 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 266835010303 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266835010304 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835010305 metal binding site [ion binding]; metal-binding site 266835010306 active site 266835010307 I-site; other site 266835010308 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 266835010309 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266835010310 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 266835010311 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 266835010312 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 266835010313 trimer interface [polypeptide binding]; other site 266835010314 active site 266835010315 substrate binding site [chemical binding]; other site 266835010316 CoA binding site [chemical binding]; other site 266835010317 Protein of unknown function (DUF805); Region: DUF805; cl01224 266835010318 Protein of unknown function (DUF805); Region: DUF805; cl01224 266835010319 2-dehydropantoate 2-reductase; Provisional; Region: PRK08229 266835010320 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835010321 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 266835010322 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 266835010323 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 266835010324 metal binding site [ion binding]; metal-binding site 266835010325 dimer interface [polypeptide binding]; other site 266835010326 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 266835010327 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 266835010328 dimerization interface 3.5A [polypeptide binding]; other site 266835010329 active site 266835010330 Predicted acetyltransferase [General function prediction only]; Region: COG3153 266835010331 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835010332 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 266835010333 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 266835010334 putative active site [active] 266835010335 substrate binding site [chemical binding]; other site 266835010336 putative cosubstrate binding site; other site 266835010337 catalytic site [active] 266835010338 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 266835010339 substrate binding site [chemical binding]; other site 266835010340 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 266835010341 active site 266835010342 catalytic residues [active] 266835010343 metal binding site [ion binding]; metal-binding site 266835010344 RmuC family; Region: RmuC; pfam02646 266835010345 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835010346 S-adenosylmethionine binding site [chemical binding]; other site 266835010347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835010348 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 266835010349 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 266835010350 Cation efflux family; Region: Cation_efflux; cl00316 266835010351 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 266835010352 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 266835010353 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 266835010354 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 266835010355 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266835010356 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266835010357 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266835010358 Domain of unknown function DUF20; Region: UPF0118; cl00465 266835010359 N-acetyltransferase; Region: Acetyltransf_2; cl00949 266835010360 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266835010361 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266835010362 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 266835010363 active site 266835010364 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266835010365 Helix-turn-helix domains; Region: HTH; cl00088 266835010366 Protein of unknown function (DUF1185); Region: DUF1185; pfam06684 266835010367 ApbE family; Region: ApbE; cl00643 266835010368 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266835010369 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 266835010370 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266835010371 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 266835010372 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 266835010373 Isochorismatase family; Region: Isochorismatase; pfam00857 266835010374 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 266835010375 catalytic triad [active] 266835010376 metal binding site [ion binding]; metal-binding site 266835010377 conserved cis-peptide bond; other site 266835010378 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 266835010379 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 266835010380 transmembrane helices; other site 266835010381 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266835010382 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 266835010383 Walker A/P-loop; other site 266835010384 ATP binding site [chemical binding]; other site 266835010385 Q-loop/lid; other site 266835010386 ABC transporter signature motif; other site 266835010387 Walker B; other site 266835010388 D-loop; other site 266835010389 H-loop/switch region; other site 266835010390 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266835010391 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 266835010392 Walker A/P-loop; other site 266835010393 ATP binding site [chemical binding]; other site 266835010394 Q-loop/lid; other site 266835010395 ABC transporter signature motif; other site 266835010396 Walker B; other site 266835010397 D-loop; other site 266835010398 H-loop/switch region; other site 266835010399 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266835010400 TM-ABC transporter signature motif; other site 266835010401 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266835010402 TM-ABC transporter signature motif; other site 266835010403 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266835010404 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 266835010405 ligand binding site [chemical binding]; other site 266835010406 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 266835010407 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 266835010408 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 266835010409 active site 266835010410 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266835010411 Helix-turn-helix domains; Region: HTH; cl00088 266835010412 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835010413 dimerization interface [polypeptide binding]; other site 266835010414 Arginase family; Region: Arginase; cl00306 266835010415 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266835010416 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835010417 substrate binding pocket [chemical binding]; other site 266835010418 membrane-bound complex binding site; other site 266835010419 hinge residues; other site 266835010420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835010421 dimer interface [polypeptide binding]; other site 266835010422 conserved gate region; other site 266835010423 putative PBP binding loops; other site 266835010424 ABC-ATPase subunit interface; other site 266835010425 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266835010426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835010427 dimer interface [polypeptide binding]; other site 266835010428 conserved gate region; other site 266835010429 putative PBP binding loops; other site 266835010430 ABC-ATPase subunit interface; other site 266835010431 Helix-turn-helix domain; Region: HTH_18; pfam12833 266835010432 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835010433 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 266835010434 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 266835010435 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835010436 Cytochrome c; Region: Cytochrom_C; cl11414 266835010437 multidrug efflux protein; Reviewed; Region: PRK01766 266835010438 MatE; Region: MatE; cl10513 266835010439 MatE; Region: MatE; cl10513 266835010440 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266835010441 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835010442 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835010443 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835010444 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835010445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835010446 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835010447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835010448 dimer interface [polypeptide binding]; other site 266835010449 conserved gate region; other site 266835010450 putative PBP binding loops; other site 266835010451 ABC-ATPase subunit interface; other site 266835010452 L-idonate 5-dehydrogenase; Region: PLN02702 266835010453 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 266835010454 inhibitor binding site; inhibition site 266835010455 catalytic Zn binding site [ion binding]; other site 266835010456 structural Zn binding site [ion binding]; other site 266835010457 NADP binding site [chemical binding]; other site 266835010458 tetramer interface [polypeptide binding]; other site 266835010459 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266835010460 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 266835010461 Walker A/P-loop; other site 266835010462 ATP binding site [chemical binding]; other site 266835010463 Q-loop/lid; other site 266835010464 ABC transporter signature motif; other site 266835010465 Walker B; other site 266835010466 D-loop; other site 266835010467 H-loop/switch region; other site 266835010468 TOBE domain; Region: TOBE_2; cl01440 266835010469 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 266835010470 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 266835010471 N- and C-terminal domain interface [polypeptide binding]; other site 266835010472 putative active site [active] 266835010473 putative MgATP binding site [chemical binding]; other site 266835010474 catalytic site [active] 266835010475 metal binding site [ion binding]; metal-binding site 266835010476 carbohydrate binding site [chemical binding]; other site 266835010477 putative homodimer interface [polypeptide binding]; other site 266835010478 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 266835010479 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266835010480 motif II; other site 266835010481 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 266835010482 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 266835010483 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 266835010484 sorbitol dehydrogenase; Provisional; Region: PRK07067 266835010485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835010486 NAD(P) binding site [chemical binding]; other site 266835010487 active site 266835010488 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266835010489 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 266835010490 Walker A/P-loop; other site 266835010491 ATP binding site [chemical binding]; other site 266835010492 Q-loop/lid; other site 266835010493 ABC transporter signature motif; other site 266835010494 Walker B; other site 266835010495 D-loop; other site 266835010496 H-loop/switch region; other site 266835010497 TOBE domain; Region: TOBE_2; cl01440 266835010498 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835010499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835010500 dimer interface [polypeptide binding]; other site 266835010501 conserved gate region; other site 266835010502 putative PBP binding loops; other site 266835010503 ABC-ATPase subunit interface; other site 266835010504 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 266835010505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835010506 putative PBP binding loops; other site 266835010507 dimer interface [polypeptide binding]; other site 266835010508 ABC-ATPase subunit interface; other site 266835010509 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835010510 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266835010511 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266835010512 Helix-turn-helix domains; Region: HTH; cl00088 266835010513 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266835010514 dimerization interface [polypeptide binding]; other site 266835010515 substrate binding pocket [chemical binding]; other site 266835010516 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 266835010517 Helix-turn-helix domains; Region: HTH; cl00088 266835010518 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 266835010519 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 266835010520 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266835010521 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266835010522 motif II; other site 266835010523 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 266835010524 active site 266835010525 intersubunit interface [polypeptide binding]; other site 266835010526 Zn2+ binding site [ion binding]; other site 266835010527 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835010528 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 266835010529 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 266835010530 UreF; Region: UreF; pfam01730 266835010531 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 266835010532 dimer interface [polypeptide binding]; other site 266835010533 catalytic residues [active] 266835010534 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 266835010535 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835010536 putative C-terminal domain interface [polypeptide binding]; other site 266835010537 putative GSH binding site (G-site) [chemical binding]; other site 266835010538 putative dimer interface [polypeptide binding]; other site 266835010539 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 266835010540 dimer interface [polypeptide binding]; other site 266835010541 N-terminal domain interface [polypeptide binding]; other site 266835010542 putative substrate binding pocket (H-site) [chemical binding]; other site 266835010543 urease subunit alpha; Reviewed; Region: ureC; PRK13207 266835010544 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 266835010545 subunit interactions [polypeptide binding]; other site 266835010546 active site 266835010547 flap region; other site 266835010548 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 266835010549 gamma-beta subunit interface [polypeptide binding]; other site 266835010550 alpha-beta subunit interface [polypeptide binding]; other site 266835010551 HupE / UreJ protein; Region: HupE_UreJ; cl01011 266835010552 Protein of unknown function (DUF1272); Region: DUF1272; cl01568 266835010553 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 266835010554 alpha-gamma subunit interface [polypeptide binding]; other site 266835010555 beta-gamma subunit interface [polypeptide binding]; other site 266835010556 UreD urease accessory protein; Region: UreD; cl00530 266835010557 Phosphopantetheine attachment site; Region: PP-binding; cl09936 266835010558 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 266835010559 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 266835010560 dimer interface [polypeptide binding]; other site 266835010561 active site 266835010562 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 266835010563 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 266835010564 C-terminal domain interface [polypeptide binding]; other site 266835010565 GSH binding site (G-site) [chemical binding]; other site 266835010566 dimer interface [polypeptide binding]; other site 266835010567 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 266835010568 dimer interface [polypeptide binding]; other site 266835010569 N-terminal domain interface [polypeptide binding]; other site 266835010570 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835010571 active site 266835010572 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 266835010573 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 266835010574 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266835010575 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835010576 DNA binding site [nucleotide binding] 266835010577 domain linker motif; other site 266835010578 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 266835010579 putative dimerization interface [polypeptide binding]; other site 266835010580 putative ligand binding site [chemical binding]; other site 266835010581 Periplasmic sugar-binding domain of Thermotoga maritima glucose-binding protein (tmGBP) and its close homologs; Region: PBP1_tmGBP; cd06314 266835010582 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266835010583 ligand binding site [chemical binding]; other site 266835010584 dimerization interface [polypeptide binding]; other site 266835010585 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835010586 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 266835010587 Walker A/P-loop; other site 266835010588 ATP binding site [chemical binding]; other site 266835010589 Q-loop/lid; other site 266835010590 ABC transporter signature motif; other site 266835010591 Walker B; other site 266835010592 D-loop; other site 266835010593 H-loop/switch region; other site 266835010594 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 266835010595 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835010596 TM-ABC transporter signature motif; other site 266835010597 Predicted membrane protein [Function unknown]; Region: COG4280 266835010598 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835010599 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 266835010600 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 266835010601 active site 266835010602 Protein of unknown function (DUF1045); Region: DUF1045; cl15435 266835010603 KduI/IolB family; Region: KduI; cl01508 266835010604 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266835010605 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 266835010606 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266835010607 dimer interface [polypeptide binding]; other site 266835010608 PYR/PP interface [polypeptide binding]; other site 266835010609 TPP binding site [chemical binding]; other site 266835010610 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 266835010611 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 266835010612 TPP-binding site; other site 266835010613 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266835010614 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 266835010615 substrate binding site [chemical binding]; other site 266835010616 ATP binding site [chemical binding]; other site 266835010617 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 266835010618 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266835010619 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266835010620 putative active site [active] 266835010621 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835010622 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835010623 Helix-turn-helix domains; Region: HTH; cl00088 266835010624 WYL domain; Region: WYL; cl14852 266835010625 LysE type translocator; Region: LysE; cl00565 266835010626 NeuB family; Region: NeuB; cl00496 266835010627 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 266835010628 short chain dehydrogenase; Provisional; Region: PRK06198 266835010629 classical (c) SDRs; Region: SDR_c; cd05233 266835010630 NAD(P) binding site [chemical binding]; other site 266835010631 active site 266835010632 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835010633 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835010634 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 266835010635 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266835010636 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835010637 Walker A/P-loop; other site 266835010638 ATP binding site [chemical binding]; other site 266835010639 Q-loop/lid; other site 266835010640 ABC transporter signature motif; other site 266835010641 Walker B; other site 266835010642 D-loop; other site 266835010643 H-loop/switch region; other site 266835010644 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835010645 TM-ABC transporter signature motif; other site 266835010646 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 266835010647 putative ligand binding site [chemical binding]; other site 266835010648 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266835010649 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835010650 DNA binding site [nucleotide binding] 266835010651 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 266835010652 putative ligand binding site [chemical binding]; other site 266835010653 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 266835010654 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 266835010655 putative di-iron ligands [ion binding]; other site 266835010656 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 266835010657 [2Fe-2S] cluster binding site [ion binding]; other site 266835010658 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 266835010659 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835010660 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266835010661 Protein of unknown function (DUF1402); Region: DUF1402; pfam07182 266835010662 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 266835010663 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835010664 Walker A motif; other site 266835010665 ATP binding site [chemical binding]; other site 266835010666 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835010667 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 266835010668 Protein of unknown function (DUF2585); Region: DUF2585; cl07906 266835010669 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 266835010670 Siderophore biosynthesis protein domain; Region: AlcB; cl11000 266835010671 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835010672 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 266835010673 active site 266835010674 HslU subunit interaction site [polypeptide binding]; other site 266835010675 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 266835010676 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 266835010677 putative active site pocket [active] 266835010678 4-fold oligomerization interface [polypeptide binding]; other site 266835010679 metal binding residues [ion binding]; metal-binding site 266835010680 3-fold/trimer interface [polypeptide binding]; other site 266835010681 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 266835010682 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 266835010683 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 266835010684 putative active site [active] 266835010685 oxyanion strand; other site 266835010686 catalytic triad [active] 266835010687 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 266835010688 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 266835010689 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 266835010690 catalytic residues [active] 266835010691 Arginase family; Region: Arginase; cl00306 266835010692 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 266835010693 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 266835010694 substrate binding site [chemical binding]; other site 266835010695 glutamase interaction surface [polypeptide binding]; other site 266835010696 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 266835010697 pantothenate kinase; Provisional; Region: PRK05439 266835010698 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 266835010699 ATP-binding site [chemical binding]; other site 266835010700 CoA-binding site [chemical binding]; other site 266835010701 Mg2+-binding site [ion binding]; other site 266835010702 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 266835010703 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 266835010704 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266835010705 protein binding site [polypeptide binding]; other site 266835010706 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266835010707 protein binding site [polypeptide binding]; other site 266835010708 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266835010709 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 266835010710 active site 266835010711 ADP/pyrophosphate binding site [chemical binding]; other site 266835010712 dimerization interface [polypeptide binding]; other site 266835010713 allosteric effector site; other site 266835010714 fructose-1,6-bisphosphate binding site; other site 266835010715 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 266835010716 LysE type translocator; Region: LysE; cl00565 266835010717 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 266835010718 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 266835010719 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 266835010720 N- and C-terminal domain interface [polypeptide binding]; other site 266835010721 D-xylulose kinase; Region: XylB; TIGR01312 266835010722 active site 266835010723 catalytic site [active] 266835010724 metal binding site [ion binding]; metal-binding site 266835010725 xylulose binding site [chemical binding]; other site 266835010726 putative ATP binding site [chemical binding]; other site 266835010727 homodimer interface [polypeptide binding]; other site 266835010728 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266835010729 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 266835010730 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 266835010731 conserved cys residue [active] 266835010732 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266835010733 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 266835010734 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 266835010735 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 266835010736 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835010737 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266835010738 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266835010739 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266835010740 active site 266835010741 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 266835010742 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835010743 CoA-ligase; Region: Ligase_CoA; cl02894 266835010744 ATP-grasp domain; Region: ATP-grasp_4; cl03087 266835010745 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 266835010746 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835010747 substrate binding site [chemical binding]; other site 266835010748 oxyanion hole (OAH) forming residues; other site 266835010749 trimer interface [polypeptide binding]; other site 266835010750 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835010751 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266835010752 substrate binding pocket [chemical binding]; other site 266835010753 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835010754 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835010755 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835010756 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 266835010757 YceI-like domain; Region: YceI; cl01001 266835010758 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 266835010759 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835010760 Helix-turn-helix domains; Region: HTH; cl00088 266835010761 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 266835010762 putative effector binding pocket; other site 266835010763 putative dimerization interface [polypeptide binding]; other site 266835010764 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 266835010765 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835010766 active site 266835010767 catalytic tetrad [active] 266835010768 Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435 266835010769 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 266835010770 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 266835010771 putative tRNA-binding site [nucleotide binding]; other site 266835010772 B3/4 domain; Region: B3_4; cl11458 266835010773 tRNA synthetase B5 domain; Region: B5; cl08394 266835010774 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 266835010775 dimer interface [polypeptide binding]; other site 266835010776 motif 1; other site 266835010777 motif 3; other site 266835010778 motif 2; other site 266835010779 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 266835010780 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 266835010781 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 266835010782 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 266835010783 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 266835010784 dimer interface [polypeptide binding]; other site 266835010785 motif 1; other site 266835010786 active site 266835010787 motif 2; other site 266835010788 motif 3; other site 266835010789 ribosomal protein L20; Region: rpl20; CHL00068 266835010790 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 266835010791 23S rRNA binding site [nucleotide binding]; other site 266835010792 L21 binding site [polypeptide binding]; other site 266835010793 L13 binding site [polypeptide binding]; other site 266835010794 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 266835010795 Phospholipid methyltransferase; Region: PEMT; cl00763 266835010796 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 266835010797 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 266835010798 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 266835010799 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835010800 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835010801 Benzoate membrane transport protein; Region: BenE; pfam03594 266835010802 benzoate transporter; Region: benE; TIGR00843 266835010803 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 266835010804 Protein of unknown function DUF45; Region: DUF45; cl00636 266835010805 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 266835010806 active site 266835010807 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 266835010808 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 266835010809 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835010810 catalytic residue [active] 266835010811 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 266835010812 substrate binding site [chemical binding]; other site 266835010813 active site 266835010814 catalytic residues [active] 266835010815 heterodimer interface [polypeptide binding]; other site 266835010816 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 266835010817 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 266835010818 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 266835010819 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835010820 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 266835010821 active site 266835010822 metal binding site [ion binding]; metal-binding site 266835010823 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 266835010824 oligomeric interface; other site 266835010825 putative active site [active] 266835010826 homodimer interface [polypeptide binding]; other site 266835010827 Cupin domain; Region: Cupin_2; cl09118 266835010828 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 266835010829 catalytic residues [active] 266835010830 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 266835010831 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835010832 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835010833 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 266835010834 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 266835010835 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 266835010836 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 266835010837 Substrate binding site; other site 266835010838 metal-binding site 266835010839 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 266835010840 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 266835010841 PAS fold; Region: PAS_7; pfam12860 266835010842 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 266835010843 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835010844 dimer interface [polypeptide binding]; other site 266835010845 phosphorylation site [posttranslational modification] 266835010846 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835010847 ATP binding site [chemical binding]; other site 266835010848 Mg2+ binding site [ion binding]; other site 266835010849 G-X-G motif; other site 266835010850 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 266835010851 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401 266835010852 oligomerization interface [polypeptide binding]; other site 266835010853 active site 266835010854 NAD+ binding site [chemical binding]; other site 266835010855 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 266835010856 dimerization domain swap beta strand [polypeptide binding]; other site 266835010857 regulatory protein interface [polypeptide binding]; other site 266835010858 active site 266835010859 regulatory phosphorylation site [posttranslational modification]; other site 266835010860 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 266835010861 active pocket/dimerization site; other site 266835010862 active site 266835010863 phosphorylation site [posttranslational modification] 266835010864 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 266835010865 active site 266835010866 metal-binding site [ion binding] 266835010867 nucleotide-binding site [chemical binding]; other site 266835010868 proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785 266835010869 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835010870 dimer interface [polypeptide binding]; other site 266835010871 phosphorylation site [posttranslational modification] 266835010872 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835010873 ATP binding site [chemical binding]; other site 266835010874 Mg2+ binding site [ion binding]; other site 266835010875 G-X-G motif; other site 266835010876 proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787 266835010877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835010878 active site 266835010879 phosphorylation site [posttranslational modification] 266835010880 intermolecular recognition site; other site 266835010881 dimerization interface [polypeptide binding]; other site 266835010882 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835010883 DNA binding site [nucleotide binding] 266835010884 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 266835010885 active site 266835010886 substrate-binding site [chemical binding]; other site 266835010887 metal-binding site [ion binding] 266835010888 ATP binding site [chemical binding]; other site 266835010889 RF-1 domain; Region: RF-1; cl02875 266835010890 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 266835010891 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 266835010892 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 266835010893 FAD binding pocket [chemical binding]; other site 266835010894 FAD binding motif [chemical binding]; other site 266835010895 phosphate binding motif [ion binding]; other site 266835010896 beta-alpha-beta structure motif; other site 266835010897 NAD binding pocket [chemical binding]; other site 266835010898 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266835010899 catalytic loop [active] 266835010900 iron binding site [ion binding]; other site 266835010901 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 266835010902 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 266835010903 [2Fe-2S] cluster binding site [ion binding]; other site 266835010904 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 266835010905 putative alpha subunit interface [polypeptide binding]; other site 266835010906 putative active site [active] 266835010907 putative substrate binding site [chemical binding]; other site 266835010908 Fe binding site [ion binding]; other site 266835010909 Protein of unknown function (DUF680); Region: DUF680; pfam05079 266835010910 Protein of unknown function (DUF680); Region: DUF680; pfam05079 266835010911 Protein of unknown function (DUF680); Region: DUF680; pfam05079 266835010912 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266835010913 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 266835010914 Walker A/P-loop; other site 266835010915 ATP binding site [chemical binding]; other site 266835010916 Q-loop/lid; other site 266835010917 ABC transporter signature motif; other site 266835010918 Walker B; other site 266835010919 D-loop; other site 266835010920 H-loop/switch region; other site 266835010921 TOBE domain; Region: TOBE_2; cl01440 266835010922 TOBE domain; Region: TOBE_2; cl01440 266835010923 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 266835010924 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 266835010925 active site 266835010926 catalytic site [active] 266835010927 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835010928 dimer interface [polypeptide binding]; other site 266835010929 conserved gate region; other site 266835010930 putative PBP binding loops; other site 266835010931 ABC-ATPase subunit interface; other site 266835010932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835010933 dimer interface [polypeptide binding]; other site 266835010934 conserved gate region; other site 266835010935 putative PBP binding loops; other site 266835010936 ABC-ATPase subunit interface; other site 266835010937 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835010938 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835010939 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266835010940 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835010941 DNA binding site [nucleotide binding] 266835010942 domain linker motif; other site 266835010943 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 266835010944 ligand binding site [chemical binding]; other site 266835010945 Peptidase S8 family domain, uncharacterized subfamily 4; Region: Peptidases_S8_4; cd05561 266835010946 active site 266835010947 catalytic triad [active] 266835010948 RNA polymerase sigma factor; Provisional; Region: PRK12515 266835010949 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835010950 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835010951 DNA binding residues [nucleotide binding] 266835010952 Sulfatase; Region: Sulfatase; cl10460 266835010953 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835010954 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 266835010955 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 266835010956 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266835010957 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835010958 Walker A/P-loop; other site 266835010959 ATP binding site [chemical binding]; other site 266835010960 Q-loop/lid; other site 266835010961 ABC transporter signature motif; other site 266835010962 Walker B; other site 266835010963 D-loop; other site 266835010964 H-loop/switch region; other site 266835010965 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835010966 Walker A/P-loop; other site 266835010967 ATP binding site [chemical binding]; other site 266835010968 Q-loop/lid; other site 266835010969 ABC transporter signature motif; other site 266835010970 Walker B; other site 266835010971 D-loop; other site 266835010972 H-loop/switch region; other site 266835010973 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 266835010974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835010975 dimer interface [polypeptide binding]; other site 266835010976 conserved gate region; other site 266835010977 ABC-ATPase subunit interface; other site 266835010978 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835010979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835010980 dimer interface [polypeptide binding]; other site 266835010981 conserved gate region; other site 266835010982 ABC-ATPase subunit interface; other site 266835010983 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835010984 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 266835010985 Predicted acyl esterases [General function prediction only]; Region: COG2936 266835010986 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835010987 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 266835010988 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 266835010989 nucleoside/Zn binding site; other site 266835010990 dimer interface [polypeptide binding]; other site 266835010991 catalytic motif [active] 266835010992 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 266835010993 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 266835010994 hypothetical protein; Provisional; Region: PRK11171 266835010995 Cupin domain; Region: Cupin_2; cl09118 266835010996 Cupin domain; Region: Cupin_2; cl09118 266835010997 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 266835010998 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 266835010999 active site 266835011000 catalytic site [active] 266835011001 tetramer interface [polypeptide binding]; other site 266835011002 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 266835011003 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 266835011004 active site 266835011005 homotetramer interface [polypeptide binding]; other site 266835011006 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 266835011007 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266835011008 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 266835011009 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 266835011010 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 266835011011 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266835011012 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 266835011013 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 266835011014 XdhC Rossmann domain; Region: XdhC_C; pfam13478 266835011015 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266835011016 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266835011017 active site 266835011018 non-prolyl cis peptide bond; other site 266835011019 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266835011020 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 266835011021 active site 266835011022 non-prolyl cis peptide bond; other site 266835011023 LysR family transcriptional regulator; Provisional; Region: PRK14997 266835011024 Helix-turn-helix domains; Region: HTH; cl00088 266835011025 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266835011026 putative effector binding pocket; other site 266835011027 dimerization interface [polypeptide binding]; other site 266835011028 Predicted membrane protein [Function unknown]; Region: COG3748 266835011029 Protein of unknown function (DUF989); Region: DUF989; pfam06181 266835011030 Cytochrome c; Region: Cytochrom_C; cl11414 266835011031 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 266835011032 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 266835011033 active site 266835011034 Domain of unknown function (DUF336); Region: DUF336; cl01249 266835011035 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 266835011036 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 266835011037 MOFRL family; Region: MOFRL; pfam05161 266835011038 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 266835011039 Fe-S cluster binding site [ion binding]; other site 266835011040 active site 266835011041 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 266835011042 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266835011043 aminotransferase; Validated; Region: PRK07046 266835011044 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835011045 inhibitor-cofactor binding pocket; inhibition site 266835011046 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835011047 catalytic residue [active] 266835011048 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266835011049 Helix-turn-helix domains; Region: HTH; cl00088 266835011050 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 266835011051 structural tetrad; other site 266835011052 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 266835011053 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 266835011054 P-loop, Walker A motif; other site 266835011055 Base recognition motif; other site 266835011056 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 266835011057 Helix-turn-helix domains; Region: HTH; cl00088 266835011058 Cupin domain; Region: Cupin_2; cl09118 266835011059 Helix-turn-helix domain; Region: HTH_18; pfam12833 266835011060 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835011061 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 266835011062 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266835011063 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266835011064 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835011065 DNA binding site [nucleotide binding] 266835011066 domain linker motif; other site 266835011067 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 266835011068 putative dimerization interface [polypeptide binding]; other site 266835011069 putative ligand binding site [chemical binding]; other site 266835011070 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 266835011071 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835011072 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 266835011073 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 266835011074 catalytic triad [active] 266835011075 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 266835011076 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 266835011077 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835011078 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 266835011079 active site 266835011080 metal binding site [ion binding]; metal-binding site 266835011081 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 266835011082 catalytic Zn binding site [ion binding]; other site 266835011083 putative NAD(P) binding site [chemical binding]; other site 266835011084 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 266835011085 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 266835011086 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 266835011087 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266835011088 TM-ABC transporter signature motif; other site 266835011089 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 266835011090 CGNR zinc finger; Region: zf-CGNR; pfam11706 266835011091 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 266835011092 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 266835011093 dimer interface [polypeptide binding]; other site 266835011094 PYR/PP interface [polypeptide binding]; other site 266835011095 TPP binding site [chemical binding]; other site 266835011096 substrate binding site [chemical binding]; other site 266835011097 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 266835011098 TPP-binding site; other site 266835011099 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 266835011100 PAS fold; Region: PAS_7; pfam12860 266835011101 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835011102 metal binding site [ion binding]; metal-binding site 266835011103 active site 266835011104 I-site; other site 266835011105 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835011106 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835011107 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835011108 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 266835011109 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 266835011110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835011111 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 266835011112 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 266835011113 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 266835011114 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 266835011115 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835011116 Mg2+ binding site [ion binding]; other site 266835011117 G-X-G motif; other site 266835011118 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 266835011119 anchoring element; other site 266835011120 dimer interface [polypeptide binding]; other site 266835011121 ATP binding site [chemical binding]; other site 266835011122 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 266835011123 active site 266835011124 putative metal-binding site [ion binding]; other site 266835011125 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 266835011126 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 266835011127 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 266835011128 active site 266835011129 substrate pocket [chemical binding]; other site 266835011130 proteolytic cleavage site; other site 266835011131 dimer interface [polypeptide binding]; other site 266835011132 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 266835011133 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 266835011134 Cytochrome P450; Region: p450; cl12078 266835011135 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 266835011136 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 266835011137 putative NAD(P) binding site [chemical binding]; other site 266835011138 active site 266835011139 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 266835011140 conserved cys residue [active] 266835011141 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835011142 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 266835011143 conserved cys residue [active] 266835011144 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 266835011145 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266835011146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835011147 dimer interface [polypeptide binding]; other site 266835011148 conserved gate region; other site 266835011149 putative PBP binding loops; other site 266835011150 ABC-ATPase subunit interface; other site 266835011151 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266835011152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835011153 dimer interface [polypeptide binding]; other site 266835011154 conserved gate region; other site 266835011155 putative PBP binding loops; other site 266835011156 ABC-ATPase subunit interface; other site 266835011157 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835011158 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266835011159 substrate binding pocket [chemical binding]; other site 266835011160 membrane-bound complex binding site; other site 266835011161 hinge residues; other site 266835011162 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 266835011163 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 266835011164 Walker A/P-loop; other site 266835011165 ATP binding site [chemical binding]; other site 266835011166 Q-loop/lid; other site 266835011167 ABC transporter signature motif; other site 266835011168 Walker B; other site 266835011169 D-loop; other site 266835011170 H-loop/switch region; other site 266835011171 Amidinotransferase; Region: Amidinotransf; cl12043 266835011172 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 266835011173 Helix-turn-helix domains; Region: HTH; cl00088 266835011174 hypothetical protein; Provisional; Region: PRK07524 266835011175 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266835011176 PYR/PP interface [polypeptide binding]; other site 266835011177 dimer interface [polypeptide binding]; other site 266835011178 TPP binding site [chemical binding]; other site 266835011179 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 266835011180 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 266835011181 TPP-binding site [chemical binding]; other site 266835011182 short chain dehydrogenase; Provisional; Region: PRK12828 266835011183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835011184 NAD(P) binding site [chemical binding]; other site 266835011185 active site 266835011186 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 266835011187 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 266835011188 RNA binding site [nucleotide binding]; other site 266835011189 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 266835011190 RNA binding site [nucleotide binding]; other site 266835011191 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 266835011192 RNA binding site [nucleotide binding]; other site 266835011193 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 266835011194 RNA binding site [nucleotide binding]; other site 266835011195 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec5; cd05690 266835011196 RNA binding site [nucleotide binding]; other site 266835011197 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691 266835011198 RNA binding site [nucleotide binding]; other site 266835011199 cytidylate kinase; Provisional; Region: cmk; PRK00023 266835011200 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 266835011201 CMP-binding site; other site 266835011202 The sites determining sugar specificity; other site 266835011203 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 266835011204 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 266835011205 hinge; other site 266835011206 active site 266835011207 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; cl15701 266835011208 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 266835011209 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 266835011210 active site 266835011211 dimer interface [polypeptide binding]; other site 266835011212 non-prolyl cis peptide bond; other site 266835011213 insertion regions; other site 266835011214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 266835011215 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835011216 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 266835011217 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 266835011218 active site 266835011219 dimer interface [polypeptide binding]; other site 266835011220 non-prolyl cis peptide bond; other site 266835011221 insertion regions; other site 266835011222 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266835011223 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 266835011224 Walker A/P-loop; other site 266835011225 ATP binding site [chemical binding]; other site 266835011226 Q-loop/lid; other site 266835011227 ABC transporter signature motif; other site 266835011228 Walker B; other site 266835011229 D-loop; other site 266835011230 H-loop/switch region; other site 266835011231 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266835011232 TM-ABC transporter signature motif; other site 266835011233 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266835011234 TM-ABC transporter signature motif; other site 266835011235 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 266835011236 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266835011237 putative ligand binding site [chemical binding]; other site 266835011238 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266835011239 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 266835011240 Walker A/P-loop; other site 266835011241 ATP binding site [chemical binding]; other site 266835011242 Q-loop/lid; other site 266835011243 ABC transporter signature motif; other site 266835011244 Walker B; other site 266835011245 D-loop; other site 266835011246 H-loop/switch region; other site 266835011247 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 266835011248 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 266835011249 Flavin binding site [chemical binding]; other site 266835011250 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 266835011251 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 266835011252 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 266835011253 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835011254 Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767 266835011255 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 266835011256 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835011257 Helix-turn-helix domains; Region: HTH; cl00088 266835011258 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 266835011259 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835011260 NAD(P) binding site [chemical binding]; other site 266835011261 catalytic residues [active] 266835011262 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 266835011263 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266835011264 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266835011265 mercuric reductase; Validated; Region: PRK06370 266835011266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835011267 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266835011268 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266835011269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 266835011270 Putative glucoamylase; Region: Glycoamylase; pfam10091 266835011271 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266835011272 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835011273 NAD(P) binding site [chemical binding]; other site 266835011274 active site 266835011275 transcriptional regulator EpsA; Region: EpsA; TIGR03020 266835011276 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835011277 DNA binding residues [nucleotide binding] 266835011278 dimerization interface [polypeptide binding]; other site 266835011279 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 266835011280 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266835011281 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 266835011282 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 266835011283 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 266835011284 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 266835011285 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266835011286 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835011287 NAD(P) binding site [chemical binding]; other site 266835011288 active site 266835011289 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 266835011290 O-Antigen ligase; Region: Wzy_C; cl04850 266835011291 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 266835011292 SLBB domain; Region: SLBB; pfam10531 266835011293 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 266835011294 Bacterial sugar transferase; Region: Bac_transf; cl00939 266835011295 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266835011296 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 266835011297 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835011298 Walker A/P-loop; other site 266835011299 ATP binding site [chemical binding]; other site 266835011300 Q-loop/lid; other site 266835011301 ABC transporter signature motif; other site 266835011302 Walker B; other site 266835011303 D-loop; other site 266835011304 H-loop/switch region; other site 266835011305 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 266835011306 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 266835011307 active site 266835011308 dimer interface [polypeptide binding]; other site 266835011309 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 266835011310 Ligand Binding Site [chemical binding]; other site 266835011311 Molecular Tunnel; other site 266835011312 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 266835011313 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 266835011314 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 266835011315 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 266835011316 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 266835011317 active site 266835011318 active site 266835011319 catalytic residues [active] 266835011320 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 266835011321 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835011322 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 266835011323 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835011324 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 266835011325 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266835011326 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266835011327 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266835011328 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266835011329 active site 266835011330 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266835011331 colanic acid exporter; Provisional; Region: PRK10459 266835011332 MatE; Region: MatE; cl10513 266835011333 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 266835011334 Ligand binding site; other site 266835011335 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266835011336 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 266835011337 active site 266835011338 putative glycosyl transferase; Provisional; Region: PRK10073 266835011339 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 266835011340 active site 266835011341 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 266835011342 active site 266835011343 tetramer interface; other site 266835011344 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 266835011345 Chain length determinant protein; Region: Wzz; cl01623 266835011346 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835011347 Helix-turn-helix domains; Region: HTH; cl00088 266835011348 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835011349 dimerization interface [polypeptide binding]; other site 266835011350 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266835011351 classical (c) SDRs; Region: SDR_c; cd05233 266835011352 NAD(P) binding site [chemical binding]; other site 266835011353 active site 266835011354 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266835011355 classical (c) SDRs; Region: SDR_c; cd05233 266835011356 NAD(P) binding site [chemical binding]; other site 266835011357 active site 266835011358 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 266835011359 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835011360 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266835011361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835011362 OpgC protein; Region: OpgC_C; cl00792 266835011363 Acyltransferase family; Region: Acyl_transf_3; pfam01757 266835011364 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 266835011365 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 266835011366 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 266835011367 Predicted secreted protein (DUF2259); Region: DUF2259; cl02309 266835011368 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 266835011369 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 266835011370 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 266835011371 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 266835011372 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 266835011373 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 266835011374 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 266835011375 dimerization domain swap beta strand [polypeptide binding]; other site 266835011376 regulatory protein interface [polypeptide binding]; other site 266835011377 active site 266835011378 regulatory phosphorylation site [posttranslational modification]; other site 266835011379 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 266835011380 active pocket/dimerization site; other site 266835011381 active site 266835011382 phosphorylation site [posttranslational modification] 266835011383 DAK2 domain; Region: Dak2; cl03685 266835011384 dihydroxyacetone kinase-like protein; Provisional; Region: PTZ00375 266835011385 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 266835011386 DAK2 domain; Region: Dak2; cl03685 266835011387 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266835011388 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 266835011389 Walker A/P-loop; other site 266835011390 ATP binding site [chemical binding]; other site 266835011391 Q-loop/lid; other site 266835011392 ABC transporter signature motif; other site 266835011393 Walker B; other site 266835011394 D-loop; other site 266835011395 H-loop/switch region; other site 266835011396 TOBE domain; Region: TOBE_2; cl01440 266835011397 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266835011398 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 266835011399 Walker A/P-loop; other site 266835011400 ATP binding site [chemical binding]; other site 266835011401 Q-loop/lid; other site 266835011402 ABC transporter signature motif; other site 266835011403 Walker B; other site 266835011404 D-loop; other site 266835011405 H-loop/switch region; other site 266835011406 TOBE domain; Region: TOBE_2; cl01440 266835011407 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835011408 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835011409 dimer interface [polypeptide binding]; other site 266835011410 conserved gate region; other site 266835011411 putative PBP binding loops; other site 266835011412 ABC-ATPase subunit interface; other site 266835011413 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835011414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835011415 dimer interface [polypeptide binding]; other site 266835011416 conserved gate region; other site 266835011417 putative PBP binding loops; other site 266835011418 ABC-ATPase subunit interface; other site 266835011419 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835011420 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835011421 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835011422 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 266835011423 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266835011424 EamA-like transporter family; Region: EamA; cl01037 266835011425 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 266835011426 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266835011427 ATP binding site [chemical binding]; other site 266835011428 putative Mg++ binding site [ion binding]; other site 266835011429 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266835011430 nucleotide binding region [chemical binding]; other site 266835011431 ATP-binding site [chemical binding]; other site 266835011432 Helicase associated domain (HA2); Region: HA2; cl04503 266835011433 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 266835011434 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 266835011435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835011436 ATP binding site [chemical binding]; other site 266835011437 Mg2+ binding site [ion binding]; other site 266835011438 G-X-G motif; other site 266835011439 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 266835011440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835011441 active site 266835011442 phosphorylation site [posttranslational modification] 266835011443 intermolecular recognition site; other site 266835011444 dimerization interface [polypeptide binding]; other site 266835011445 Helix-turn-helix domains; Region: HTH; cl00088 266835011446 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 266835011447 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 266835011448 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 266835011449 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 266835011450 DNA binding residues [nucleotide binding] 266835011451 dimer interface [polypeptide binding]; other site 266835011452 copper binding site [ion binding]; other site 266835011453 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 266835011454 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 266835011455 NifU-like domain; Region: NifU; cl00484 266835011456 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266835011457 Ligand Binding Site [chemical binding]; other site 266835011458 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 266835011459 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 266835011460 active site 266835011461 HIGH motif; other site 266835011462 dimer interface [polypeptide binding]; other site 266835011463 KMSKS motif; other site 266835011464 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266835011465 active site 266835011466 Cupin domain; Region: Cupin_2; cl09118 266835011467 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 266835011468 PII uridylyl-transferase; Provisional; Region: PRK05092 266835011469 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 266835011470 metal binding triad; other site 266835011471 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 266835011472 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 266835011473 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 266835011474 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 266835011475 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 266835011476 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 266835011477 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 266835011478 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266835011479 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266835011480 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266835011481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 266835011482 Domain of unknown function (DUF305); Region: DUF305; pfam03713 266835011483 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835011484 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 266835011485 active site 266835011486 catalytic tetrad [active] 266835011487 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 266835011488 MutS domain I; Region: MutS_I; pfam01624 266835011489 MutS domain II; Region: MutS_II; pfam05188 266835011490 MutS family domain IV; Region: MutS_IV; pfam05190 266835011491 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 266835011492 Walker A/P-loop; other site 266835011493 ATP binding site [chemical binding]; other site 266835011494 Q-loop/lid; other site 266835011495 ABC transporter signature motif; other site 266835011496 Walker B; other site 266835011497 D-loop; other site 266835011498 H-loop/switch region; other site 266835011499 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 266835011500 Malic enzyme, N-terminal domain; Region: malic; pfam00390 266835011501 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 266835011502 putative NAD(P) binding site [chemical binding]; other site 266835011503 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 266835011504 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835011505 PAS fold; Region: PAS_3; pfam08447 266835011506 putative active site [active] 266835011507 heme pocket [chemical binding]; other site 266835011508 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835011509 metal binding site [ion binding]; metal-binding site 266835011510 active site 266835011511 I-site; other site 266835011512 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 266835011513 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine...; Region: adenosine_kinase; cd01168 266835011514 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266835011515 substrate binding site [chemical binding]; other site 266835011516 ATP binding site [chemical binding]; other site 266835011517 EamA-like transporter family; Region: EamA; cl01037 266835011518 EamA-like transporter family; Region: EamA; cl01037 266835011519 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 266835011520 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 266835011521 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266835011522 tetramer interface [polypeptide binding]; other site 266835011523 active site 266835011524 Mg2+/Mn2+ binding site [ion binding]; other site 266835011525 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 266835011526 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266835011527 motif II; other site 266835011528 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 266835011529 trimer interface [polypeptide binding]; other site 266835011530 active site 266835011531 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 266835011532 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835011533 putative DNA binding site [nucleotide binding]; other site 266835011534 putative Zn2+ binding site [ion binding]; other site 266835011535 Helix-turn-helix domains; Region: HTH; cl00088 266835011536 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 266835011537 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 266835011538 putative active site [active] 266835011539 putative dimer interface [polypeptide binding]; other site 266835011540 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 266835011541 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 266835011542 FAD dependent oxidoreductase; Region: DAO; pfam01266 266835011543 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835011544 haloalkane dehalogenase; Provisional; Region: PRK03592 266835011545 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 266835011546 RF3 subfamily. Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria. Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169 266835011547 G1 box; other site 266835011548 putative GEF interaction site [polypeptide binding]; other site 266835011549 GTP/Mg2+ binding site [chemical binding]; other site 266835011550 Switch I region; other site 266835011551 G2 box; other site 266835011552 G3 box; other site 266835011553 Switch II region; other site 266835011554 G4 box; other site 266835011555 G5 box; other site 266835011556 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 266835011557 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 266835011558 dimer interface [polypeptide binding]; other site 266835011559 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 266835011560 putative hydrophobic ligand binding site [chemical binding]; other site 266835011561 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835011562 dimerization interface [polypeptide binding]; other site 266835011563 putative DNA binding site [nucleotide binding]; other site 266835011564 putative Zn2+ binding site [ion binding]; other site 266835011565 Dehydratase family; Region: ILVD_EDD; cl00340 266835011566 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266835011567 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 266835011568 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 266835011569 Walker A/P-loop; other site 266835011570 ATP binding site [chemical binding]; other site 266835011571 Q-loop/lid; other site 266835011572 ABC transporter signature motif; other site 266835011573 Walker B; other site 266835011574 D-loop; other site 266835011575 H-loop/switch region; other site 266835011576 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 266835011577 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 266835011578 active site 266835011579 EamA-like transporter family; Region: EamA; cl01037 266835011580 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 266835011581 Protein of unknown function (DUF805); Region: DUF805; cl01224 266835011582 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 266835011583 active site 266835011584 ATP binding site [chemical binding]; other site 266835011585 substrate binding site [chemical binding]; other site 266835011586 dimer interface [polypeptide binding]; other site 266835011587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835011588 S-adenosylmethionine binding site [chemical binding]; other site 266835011589 FAD dependent oxidoreductase; Region: DAO; pfam01266 266835011590 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 266835011591 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835011592 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 266835011593 Phosphotransferase enzyme family; Region: APH; pfam01636 266835011594 active site 266835011595 ATP binding site [chemical binding]; other site 266835011596 substrate binding site [chemical binding]; other site 266835011597 dimer interface [polypeptide binding]; other site 266835011598 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266835011599 Helix-turn-helix domains; Region: HTH; cl00088 266835011600 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 266835011601 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266835011602 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 266835011603 dimer interface [polypeptide binding]; other site 266835011604 phosphorylation site [posttranslational modification] 266835011605 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835011606 ATP binding site [chemical binding]; other site 266835011607 Mg2+ binding site [ion binding]; other site 266835011608 G-X-G motif; other site 266835011609 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835011610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835011611 active site 266835011612 phosphorylation site [posttranslational modification] 266835011613 intermolecular recognition site; other site 266835011614 dimerization interface [polypeptide binding]; other site 266835011615 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835011616 DNA binding site [nucleotide binding] 266835011617 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835011618 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 266835011619 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 266835011620 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835011621 Helix-turn-helix domains; Region: HTH; cl00088 266835011622 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 266835011623 putative substrate binding pocket [chemical binding]; other site 266835011624 dimerization interface [polypeptide binding]; other site 266835011625 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 266835011626 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 266835011627 DNA binding residues [nucleotide binding] 266835011628 putative dimer interface [polypeptide binding]; other site 266835011629 putative metal binding residues [ion binding]; other site 266835011630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835011631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835011632 S-adenosylmethionine binding site [chemical binding]; other site 266835011633 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835011634 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835011635 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835011636 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835011637 Walker A/P-loop; other site 266835011638 ATP binding site [chemical binding]; other site 266835011639 Q-loop/lid; other site 266835011640 ABC transporter signature motif; other site 266835011641 Walker B; other site 266835011642 D-loop; other site 266835011643 H-loop/switch region; other site 266835011644 TOBE domain; Region: TOBE_2; cl01440 266835011645 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835011646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835011647 putative PBP binding loops; other site 266835011648 dimer interface [polypeptide binding]; other site 266835011649 ABC-ATPase subunit interface; other site 266835011650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835011651 dimer interface [polypeptide binding]; other site 266835011652 conserved gate region; other site 266835011653 putative PBP binding loops; other site 266835011654 ABC-ATPase subunit interface; other site 266835011655 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835011656 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 266835011657 tetrameric interface [polypeptide binding]; other site 266835011658 NAD binding site [chemical binding]; other site 266835011659 catalytic residues [active] 266835011660 substrate binding site [chemical binding]; other site 266835011661 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835011662 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835011663 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835011664 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266835011665 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266835011666 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835011667 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835011668 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 266835011669 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835011670 DNA binding residues [nucleotide binding] 266835011671 dimerization interface [polypeptide binding]; other site 266835011672 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 266835011673 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 266835011674 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 266835011675 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266835011676 catalytic loop [active] 266835011677 iron binding site [ion binding]; other site 266835011678 4Fe-4S binding domain; Region: Fer4; cl02805 266835011679 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 266835011680 [4Fe-4S] binding site [ion binding]; other site 266835011681 molybdopterin cofactor binding site; other site 266835011682 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 266835011683 molybdopterin cofactor binding site; other site 266835011684 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 266835011685 putative dimer interface [polypeptide binding]; other site 266835011686 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 266835011687 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 266835011688 SLBB domain; Region: SLBB; pfam10531 266835011689 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 266835011690 NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905 266835011691 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 266835011692 putative dimer interface [polypeptide binding]; other site 266835011693 [2Fe-2S] cluster binding site [ion binding]; other site 266835011694 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835011695 Helix-turn-helix domains; Region: HTH; cl00088 266835011696 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266835011697 dimerization interface [polypeptide binding]; other site 266835011698 GAF domain; Region: GAF; cl00853 266835011699 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835011700 metal binding site [ion binding]; metal-binding site 266835011701 active site 266835011702 I-site; other site 266835011703 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 266835011704 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835011705 active site 266835011706 metal binding site [ion binding]; metal-binding site 266835011707 Domain of unknown function DUF59; Region: DUF59; cl00941 266835011708 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 266835011709 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 266835011710 Walker A motif; other site 266835011711 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 266835011712 putative hydrophobic ligand binding site [chemical binding]; other site 266835011713 Dehydratase family; Region: ILVD_EDD; cl00340 266835011714 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 266835011715 active site residue [active] 266835011716 Chromate resistance exported protein; Region: Chrome_Resist; cl01744 266835011717 Chromate transporter; Region: Chromate_transp; pfam02417 266835011718 Chromate transporter; Region: Chromate_transp; pfam02417 266835011719 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 266835011720 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266835011721 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835011722 DNA-binding site [nucleotide binding]; DNA binding site 266835011723 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835011724 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835011725 homodimer interface [polypeptide binding]; other site 266835011726 catalytic residue [active] 266835011727 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 266835011728 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 266835011729 active site 266835011730 dimer interface [polypeptide binding]; other site 266835011731 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 266835011732 dimer interface [polypeptide binding]; other site 266835011733 active site 266835011734 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 266835011735 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266835011736 motif II; other site 266835011737 Predicted methyltransferase [General function prediction only]; Region: COG3897 266835011738 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 266835011739 AMP-binding enzyme; Region: AMP-binding; cl15778 266835011740 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266835011741 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835011742 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 266835011743 peptide binding site [polypeptide binding]; other site 266835011744 dipeptide transporter permease DppB; Provisional; Region: PRK10914 266835011745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835011746 dimer interface [polypeptide binding]; other site 266835011747 conserved gate region; other site 266835011748 putative PBP binding loops; other site 266835011749 ABC-ATPase subunit interface; other site 266835011750 dipeptide transporter; Provisional; Region: PRK10913 266835011751 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835011752 dimer interface [polypeptide binding]; other site 266835011753 conserved gate region; other site 266835011754 putative PBP binding loops; other site 266835011755 ABC-ATPase subunit interface; other site 266835011756 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835011757 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 266835011758 Walker A/P-loop; other site 266835011759 ATP binding site [chemical binding]; other site 266835011760 Q-loop/lid; other site 266835011761 ABC transporter signature motif; other site 266835011762 Walker B; other site 266835011763 D-loop; other site 266835011764 H-loop/switch region; other site 266835011765 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835011766 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 266835011767 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835011768 Walker A/P-loop; other site 266835011769 ATP binding site [chemical binding]; other site 266835011770 Q-loop/lid; other site 266835011771 ABC transporter signature motif; other site 266835011772 Walker B; other site 266835011773 D-loop; other site 266835011774 H-loop/switch region; other site 266835011775 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835011776 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 266835011777 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266835011778 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835011779 catalytic residue [active] 266835011780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835011781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835011782 putative PBP binding loops; other site 266835011783 dimer interface [polypeptide binding]; other site 266835011784 ABC-ATPase subunit interface; other site 266835011785 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266835011786 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835011787 substrate binding pocket [chemical binding]; other site 266835011788 membrane-bound complex binding site; other site 266835011789 hinge residues; other site 266835011790 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 266835011791 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 266835011792 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 266835011793 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 266835011794 active site 266835011795 dimer interface [polypeptide binding]; other site 266835011796 non-prolyl cis peptide bond; other site 266835011797 insertion regions; other site 266835011798 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266835011799 homotrimer interaction site [polypeptide binding]; other site 266835011800 putative active site [active] 266835011801 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266835011802 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266835011803 active site 266835011804 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266835011805 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835011806 substrate binding site [chemical binding]; other site 266835011807 oxyanion hole (OAH) forming residues; other site 266835011808 trimer interface [polypeptide binding]; other site 266835011809 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266835011810 Helix-turn-helix domains; Region: HTH; cl00088 266835011811 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266835011812 classical (c) SDRs; Region: SDR_c; cd05233 266835011813 NAD(P) binding site [chemical binding]; other site 266835011814 active site 266835011815 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 266835011816 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835011817 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835011818 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 266835011819 active site 266835011820 FMN binding site [chemical binding]; other site 266835011821 substrate binding site [chemical binding]; other site 266835011822 homotetramer interface [polypeptide binding]; other site 266835011823 catalytic residue [active] 266835011824 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835011825 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 266835011826 active site 266835011827 metal binding site [ion binding]; metal-binding site 266835011828 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835011829 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 266835011830 Walker A/P-loop; other site 266835011831 ATP binding site [chemical binding]; other site 266835011832 Q-loop/lid; other site 266835011833 ABC transporter signature motif; other site 266835011834 Walker B; other site 266835011835 D-loop; other site 266835011836 H-loop/switch region; other site 266835011837 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835011838 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835011839 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 266835011840 Walker A/P-loop; other site 266835011841 ATP binding site [chemical binding]; other site 266835011842 Q-loop/lid; other site 266835011843 ABC transporter signature motif; other site 266835011844 Walker B; other site 266835011845 D-loop; other site 266835011846 H-loop/switch region; other site 266835011847 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835011848 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266835011849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835011850 dimer interface [polypeptide binding]; other site 266835011851 conserved gate region; other site 266835011852 putative PBP binding loops; other site 266835011853 ABC-ATPase subunit interface; other site 266835011854 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835011855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835011856 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 266835011857 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 266835011858 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 266835011859 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835011860 Putative cyclase; Region: Cyclase; cl00814 266835011861 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 266835011862 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835011863 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835011864 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835011865 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266835011866 Helix-turn-helix domains; Region: HTH; cl00088 266835011867 Helix-turn-helix domains; Region: HTH; cl00088 266835011868 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231 266835011869 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 266835011870 PYR/PP interface [polypeptide binding]; other site 266835011871 dimer interface [polypeptide binding]; other site 266835011872 TPP binding site [chemical binding]; other site 266835011873 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 266835011874 TPP-binding site; other site 266835011875 putative indolepyruvate oxidoreductase subunit B; Reviewed; Region: PRK08312 266835011876 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 266835011877 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 266835011878 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 266835011879 putative acyl-acceptor binding pocket; other site 266835011880 AMP-binding enzyme; Region: AMP-binding; cl15778 266835011881 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 266835011882 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 266835011883 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5267 266835011884 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 266835011885 Predicted integral membrane protein [Function unknown]; Region: COG5612 266835011886 RNA polymerase sigma factor; Reviewed; Region: PRK05602 266835011887 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835011888 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835011889 DNA binding residues [nucleotide binding] 266835011890 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl08302 266835011891 EF-hand domain pair; Region: EF_hand_5; pfam13499 266835011892 Ca2+ binding site [ion binding]; other site 266835011893 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 266835011894 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 266835011895 Phage integrase family; Region: Phage_integrase; pfam00589 266835011896 active site 266835011897 Int/Topo IB signature motif; other site 266835011898 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 266835011899 RecA-family ATPase [DNA replication, recombination, and repair]; Region: RepA; COG3598 266835011900 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835011901 Walker A motif; other site 266835011902 ATP binding site [chemical binding]; other site 266835011903 Walker B motif; other site 266835011904 DNA helicase II; Region: uvrD; TIGR01075 266835011905 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 266835011906 Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313 266835011907 Uncharacterized conserved protein [Function unknown]; Region: COG5361 266835011908 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 266835011909 Uncharacterized conserved protein [Function unknown]; Region: COG5361 266835011910 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 266835011911 Uncharacterized conserved protein [Function unknown]; Region: COG5361 266835011912 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 266835011913 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 266835011914 Sulfatase; Region: Sulfatase; cl10460 266835011915 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 266835011916 Terminase small subunit; Region: Terminase_2; cl01513 266835011917 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 266835011918 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835011919 ATP-dependent DNA ligase; Validated; Region: PRK09247 266835011920 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 266835011921 active site 266835011922 DNA binding site [nucleotide binding] 266835011923 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 266835011924 DNA binding site [nucleotide binding] 266835011925 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 266835011926 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266835011927 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 266835011928 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835011929 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835011930 S-adenosylmethionine binding site [chemical binding]; other site 266835011931 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 266835011932 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835011933 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266835011934 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835011935 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 266835011936 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835011937 Walker A/P-loop; other site 266835011938 ATP binding site [chemical binding]; other site 266835011939 Q-loop/lid; other site 266835011940 ABC transporter signature motif; other site 266835011941 Walker B; other site 266835011942 D-loop; other site 266835011943 H-loop/switch region; other site 266835011944 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835011945 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835011946 Walker A/P-loop; other site 266835011947 ATP binding site [chemical binding]; other site 266835011948 Q-loop/lid; other site 266835011949 ABC transporter signature motif; other site 266835011950 Walker B; other site 266835011951 D-loop; other site 266835011952 H-loop/switch region; other site 266835011953 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835011954 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 266835011955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835011956 dimer interface [polypeptide binding]; other site 266835011957 conserved gate region; other site 266835011958 putative PBP binding loops; other site 266835011959 ABC-ATPase subunit interface; other site 266835011960 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 266835011961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835011962 dimer interface [polypeptide binding]; other site 266835011963 conserved gate region; other site 266835011964 putative PBP binding loops; other site 266835011965 ABC-ATPase subunit interface; other site 266835011966 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 266835011967 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 266835011968 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 266835011969 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 266835011970 Cytochrome c; Region: Cytochrom_C; cl11414 266835011971 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 266835011972 Ligand binding site; other site 266835011973 oligomer interface; other site 266835011974 prephenate dehydratase; Provisional; Region: PRK11899 266835011975 Prephenate dehydratase; Region: PDT; pfam00800 266835011976 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 266835011977 putative L-Phe binding site [chemical binding]; other site 266835011978 Stress responsive A/B Barrel Domain; Region: Dabb; cl06768 266835011979 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 266835011980 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 266835011981 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 266835011982 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 266835011983 putative NADH binding site [chemical binding]; other site 266835011984 putative active site [active] 266835011985 nudix motif; other site 266835011986 putative metal binding site [ion binding]; other site 266835011987 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 266835011988 nucleotide binding site/active site [active] 266835011989 HIT family signature motif; other site 266835011990 catalytic residue [active] 266835011991 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 266835011992 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835011993 Walker A motif; other site 266835011994 ATP binding site [chemical binding]; other site 266835011995 Walker B motif; other site 266835011996 arginine finger; other site 266835011997 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 266835011998 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 266835011999 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 266835012000 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 266835012001 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 266835012002 recombination protein RecR; Reviewed; Region: recR; PRK00076 266835012003 RecR protein; Region: RecR; pfam02132 266835012004 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 266835012005 putative active site [active] 266835012006 putative metal-binding site [ion binding]; other site 266835012007 tetramer interface [polypeptide binding]; other site 266835012008 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 266835012009 lytic murein transglycosylase; Region: MltB_2; TIGR02283 266835012010 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 266835012011 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 266835012012 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 266835012013 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835012014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835012015 dimer interface [polypeptide binding]; other site 266835012016 conserved gate region; other site 266835012017 putative PBP binding loops; other site 266835012018 ABC-ATPase subunit interface; other site 266835012019 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266835012020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835012021 dimer interface [polypeptide binding]; other site 266835012022 conserved gate region; other site 266835012023 ABC-ATPase subunit interface; other site 266835012024 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835012025 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 266835012026 Walker A/P-loop; other site 266835012027 ATP binding site [chemical binding]; other site 266835012028 Q-loop/lid; other site 266835012029 ABC transporter signature motif; other site 266835012030 Walker B; other site 266835012031 D-loop; other site 266835012032 H-loop/switch region; other site 266835012033 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835012034 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 266835012035 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835012036 Walker A/P-loop; other site 266835012037 ATP binding site [chemical binding]; other site 266835012038 Q-loop/lid; other site 266835012039 ABC transporter signature motif; other site 266835012040 Walker B; other site 266835012041 D-loop; other site 266835012042 H-loop/switch region; other site 266835012043 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 266835012044 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266835012045 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266835012046 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266835012047 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266835012048 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266835012049 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 266835012050 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835012051 inhibitor-cofactor binding pocket; inhibition site 266835012052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835012053 catalytic residue [active] 266835012054 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 266835012055 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266835012056 Imelysin; Region: Peptidase_M75; cl09159 266835012057 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 266835012058 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 266835012059 heme binding site [chemical binding]; other site 266835012060 ferroxidase pore; other site 266835012061 ferroxidase diiron center [ion binding]; other site 266835012062 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 266835012063 Imelysin; Region: Peptidase_M75; cl09159 266835012064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490 266835012065 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 266835012066 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 266835012067 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835012068 Coenzyme A binding pocket [chemical binding]; other site 266835012069 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 266835012070 putative acyl-acceptor binding pocket; other site 266835012071 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 266835012072 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 266835012073 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835012074 FeS/SAM binding site; other site 266835012075 TRAM domain; Region: TRAM; cl01282 266835012076 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 266835012077 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835012078 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 266835012079 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 266835012080 Transporter associated domain; Region: CorC_HlyC; cl08393 266835012081 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 266835012082 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835012083 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266835012084 classical (c) SDRs; Region: SDR_c; cd05233 266835012085 NAD(P) binding site [chemical binding]; other site 266835012086 active site 266835012087 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835012088 Helix-turn-helix domains; Region: HTH; cl00088 266835012089 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 266835012090 putative effector binding pocket; other site 266835012091 putative dimerization interface [polypeptide binding]; other site 266835012092 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 266835012093 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 266835012094 putative active site [active] 266835012095 catalytic triad [active] 266835012096 putative dimer interface [polypeptide binding]; other site 266835012097 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266835012098 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835012099 non-specific DNA binding site [nucleotide binding]; other site 266835012100 salt bridge; other site 266835012101 sequence-specific DNA binding site [nucleotide binding]; other site 266835012102 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 266835012103 S-adenosylmethionine synthetase; Validated; Region: PRK05250 266835012104 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 266835012105 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 266835012106 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835012107 ribosome maturation protein RimP; Reviewed; Region: PRK00092 266835012108 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 266835012109 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 266835012110 Sm1 motif; other site 266835012111 D3 - B interaction site; other site 266835012112 D1 - D2 interaction site; other site 266835012113 Hfq - Hfq interaction site; other site 266835012114 RNA binding pocket [nucleotide binding]; other site 266835012115 Sm2 motif; other site 266835012116 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 266835012117 NusA N-terminal domain; Region: NusA_N; pfam08529 266835012118 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 266835012119 RNA binding site [nucleotide binding]; other site 266835012120 homodimer interface [polypeptide binding]; other site 266835012121 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 266835012122 G-X-X-G motif; other site 266835012123 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 266835012124 G-X-X-G motif; other site 266835012125 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 266835012126 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 266835012127 putative RNA binding cleft [nucleotide binding]; other site 266835012128 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 266835012129 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 266835012130 translation initiation factor IF-2; Region: IF-2; TIGR00487 266835012131 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 266835012132 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 266835012133 G1 box; other site 266835012134 putative GEF interaction site [polypeptide binding]; other site 266835012135 GTP/Mg2+ binding site [chemical binding]; other site 266835012136 Switch I region; other site 266835012137 G2 box; other site 266835012138 G3 box; other site 266835012139 Switch II region; other site 266835012140 G4 box; other site 266835012141 G5 box; other site 266835012142 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 266835012143 Translation-initiation factor 2; Region: IF-2; pfam11987 266835012144 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 266835012145 Ribosome-binding factor A; Region: RBFA; cl00542 266835012146 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 266835012147 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 266835012148 RNA binding site [nucleotide binding]; other site 266835012149 active site 266835012150 magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383 266835012151 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 266835012152 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 266835012153 16S/18S rRNA binding site [nucleotide binding]; other site 266835012154 S13e-L30e interaction site [polypeptide binding]; other site 266835012155 25S rRNA binding site [nucleotide binding]; other site 266835012156 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 266835012157 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 266835012158 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 266835012159 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 266835012160 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 266835012161 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 266835012162 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 266835012163 putative nucleic acid binding region [nucleotide binding]; other site 266835012164 G-X-X-G motif; other site 266835012165 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 266835012166 RNA binding site [nucleotide binding]; other site 266835012167 domain interface; other site 266835012168 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 266835012169 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835012170 S-adenosylmethionine binding site [chemical binding]; other site 266835012171 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835012172 metal binding site [ion binding]; metal-binding site 266835012173 active site 266835012174 I-site; other site 266835012175 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835012176 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 266835012177 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 266835012178 NAD binding site [chemical binding]; other site 266835012179 homotetramer interface [polypeptide binding]; other site 266835012180 homodimer interface [polypeptide binding]; other site 266835012181 substrate binding site [chemical binding]; other site 266835012182 active site 266835012183 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 266835012184 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 266835012185 dimer interface [polypeptide binding]; other site 266835012186 active site 266835012187 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 266835012188 active site 1 [active] 266835012189 dimer interface [polypeptide binding]; other site 266835012190 active site 2 [active] 266835012191 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 266835012192 metal binding site 2 [ion binding]; metal-binding site 266835012193 putative DNA binding helix; other site 266835012194 metal binding site 1 [ion binding]; metal-binding site 266835012195 dimer interface [polypeptide binding]; other site 266835012196 structural Zn2+ binding site [ion binding]; other site 266835012197 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 266835012198 Bacterial SH3 domain; Region: SH3_3; cl02551 266835012199 Bacterial SH3 domain; Region: SH3_3; cl02551 266835012200 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 266835012201 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835012202 Predicted acetyltransferase [General function prediction only]; Region: COG3153 266835012203 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835012204 Coenzyme A binding pocket [chemical binding]; other site 266835012205 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 266835012206 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 266835012207 ATP binding site [chemical binding]; other site 266835012208 substrate interface [chemical binding]; other site 266835012209 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 266835012210 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835012211 Walker A/P-loop; other site 266835012212 ATP binding site [chemical binding]; other site 266835012213 Q-loop/lid; other site 266835012214 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835012215 ABC transporter signature motif; other site 266835012216 Walker B; other site 266835012217 D-loop; other site 266835012218 H-loop/switch region; other site 266835012219 DNA polymerase III subunit beta; Validated; Region: PRK05643 266835012220 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 266835012221 putative DNA binding surface [nucleotide binding]; other site 266835012222 dimer interface [polypeptide binding]; other site 266835012223 beta-clamp/clamp loader binding surface; other site 266835012224 beta-clamp/translesion DNA polymerase binding surface; other site 266835012225 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 266835012226 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835012227 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 266835012228 DnaA box-binding interface [nucleotide binding]; other site 266835012229 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 266835012230 enoyl-CoA hydratase; Provisional; Region: PRK05862 266835012231 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835012232 substrate binding site [chemical binding]; other site 266835012233 oxyanion hole (OAH) forming residues; other site 266835012234 trimer interface [polypeptide binding]; other site 266835012235 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 266835012236 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 266835012237 DNA binding site [nucleotide binding] 266835012238 catalytic residue [active] 266835012239 H2TH interface [polypeptide binding]; other site 266835012240 putative catalytic residues [active] 266835012241 turnover-facilitating residue; other site 266835012242 intercalation triad [nucleotide binding]; other site 266835012243 8OG recognition residue [nucleotide binding]; other site 266835012244 putative reading head residues; other site 266835012245 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 266835012246 Sulfatase; Region: Sulfatase; cl10460 266835012247 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 266835012248 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 266835012249 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 266835012250 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 266835012251 TadE-like protein; Region: TadE; pfam07811 266835012252 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 266835012253 Flp/Fap pilin component; Region: Flp_Fap; cl01585 266835012254 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 266835012255 SAF domain; Region: SAF; cl00555 266835012256 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 266835012257 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 266835012258 BON domain; Region: BON; cl02771 266835012259 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 266835012260 Type IV pili component [Cell motility and secretion]; Region: COG5461; cl02279 266835012261 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 266835012262 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 266835012263 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 266835012264 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 266835012265 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 266835012266 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 266835012267 ATP binding site [chemical binding]; other site 266835012268 Walker A motif; other site 266835012269 hexamer interface [polypeptide binding]; other site 266835012270 Walker B motif; other site 266835012271 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 266835012272 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 266835012273 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 266835012274 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 266835012275 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835012276 binding surface 266835012277 TPR motif; other site 266835012278 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835012279 TPR motif; other site 266835012280 binding surface 266835012281 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 266835012282 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 266835012283 interface (dimer of trimers) [polypeptide binding]; other site 266835012284 Substrate-binding/catalytic site; other site 266835012285 Zn-binding sites [ion binding]; other site 266835012286 Helix-turn-helix domains; Region: HTH; cl00088 266835012287 NlpC/P60 family; Region: NLPC_P60; cl11438 266835012288 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 266835012289 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266835012290 ATP binding site [chemical binding]; other site 266835012291 putative Mg++ binding site [ion binding]; other site 266835012292 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266835012293 nucleotide binding region [chemical binding]; other site 266835012294 ATP-binding site [chemical binding]; other site 266835012295 DEAD/H associated; Region: DEAD_assoc; pfam08494 266835012296 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 266835012297 putative active site [active] 266835012298 putative metal binding site [ion binding]; other site 266835012299 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl04869 266835012300 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 266835012301 4Fe-4S binding domain; Region: Fer4; cl02805 266835012302 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 266835012303 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266835012304 molybdopterin cofactor binding site; other site 266835012305 The MopB_2 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_2; cd02763 266835012306 putative molybdopterin cofactor binding site [chemical binding]; other site 266835012307 The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_2; cd02783 266835012308 putative molybdopterin cofactor binding site; other site 266835012309 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 266835012310 Helix-turn-helix domains; Region: HTH; cl00088 266835012311 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 266835012312 putative dimerization interface [polypeptide binding]; other site 266835012313 putative chaperone; Provisional; Region: PRK11678 266835012314 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; cl09826 266835012315 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 266835012316 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266835012317 Sel1 repeat; Region: Sel1; cl02723 266835012318 Sel1 repeat; Region: Sel1; cl02723 266835012319 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 266835012320 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 266835012321 DNA binding residues [nucleotide binding] 266835012322 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 266835012323 putative dimer interface [polypeptide binding]; other site 266835012324 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 266835012325 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 266835012326 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 266835012327 FAD binding site [chemical binding]; other site 266835012328 substrate binding site [chemical binding]; other site 266835012329 catalytic residues [active] 266835012330 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 266835012331 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266835012332 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266835012333 active site 266835012334 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 266835012335 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266835012336 dimer interface [polypeptide binding]; other site 266835012337 active site 266835012338 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 266835012339 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835012340 substrate binding site [chemical binding]; other site 266835012341 oxyanion hole (OAH) forming residues; other site 266835012342 trimer interface [polypeptide binding]; other site 266835012343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835012344 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266835012345 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266835012346 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266835012347 active site 266835012348 Predicted transcriptional regulator [Transcription]; Region: COG2932 266835012349 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 266835012350 Catalytic site [active] 266835012351 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 266835012352 Catalytic site; other site 266835012353 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 266835012354 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 266835012355 active site 266835012356 HIGH motif; other site 266835012357 KMSKS motif; other site 266835012358 tellurite resistance protein terB; Region: terB; cd07176 266835012359 putative metal binding site [ion binding]; other site 266835012360 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266835012361 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835012362 substrate binding pocket [chemical binding]; other site 266835012363 membrane-bound complex binding site; other site 266835012364 hinge residues; other site 266835012365 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 266835012366 Autoinducer binding domain; Region: Autoind_bind; pfam03472 266835012367 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835012368 DNA binding residues [nucleotide binding] 266835012369 dimerization interface [polypeptide binding]; other site 266835012370 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835012371 enoyl-CoA hydratase; Provisional; Region: PRK06688 266835012372 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835012373 substrate binding site [chemical binding]; other site 266835012374 oxyanion hole (OAH) forming residues; other site 266835012375 trimer interface [polypeptide binding]; other site 266835012376 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 266835012377 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 266835012378 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835012379 dimer interface [polypeptide binding]; other site 266835012380 phosphorylation site [posttranslational modification] 266835012381 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835012382 ATP binding site [chemical binding]; other site 266835012383 Mg2+ binding site [ion binding]; other site 266835012384 G-X-G motif; other site 266835012385 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 266835012386 PhoU domain; Region: PhoU; pfam01895 266835012387 PhoU domain; Region: PhoU; pfam01895 266835012388 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 266835012389 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 266835012390 GcrA cell cycle regulator; Region: GcrA; cl11564 266835012391 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 266835012392 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835012393 inhibitor-cofactor binding pocket; inhibition site 266835012394 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835012395 catalytic residue [active] 266835012396 ornithine carbamoyltransferase; Provisional; Region: PRK00779 266835012397 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 266835012398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835012399 Disulfide bond chaperones of the HSP33 family [Posttranslational modification, protein turnover, chaperones]; Region: COG1281 266835012400 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 266835012401 dimerization interface [polypeptide binding]; other site 266835012402 domain crossover interface; other site 266835012403 redox-dependent activation switch; other site 266835012404 Protein of unknown function (DUF525); Region: DUF525; cl01119 266835012405 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 266835012406 ligand binding site; other site 266835012407 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 266835012408 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 266835012409 homodimer interface [polypeptide binding]; other site 266835012410 substrate-cofactor binding pocket; other site 266835012411 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835012412 catalytic residue [active] 266835012413 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 266835012414 trimer interface [polypeptide binding]; other site 266835012415 active site 266835012416 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 266835012417 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835012418 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266835012419 substrate binding pocket [chemical binding]; other site 266835012420 membrane-bound complex binding site; other site 266835012421 hinge residues; other site 266835012422 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 266835012423 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835012424 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835012425 TM-ABC transporter signature motif; other site 266835012426 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 266835012427 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 266835012428 Walker A/P-loop; other site 266835012429 ATP binding site [chemical binding]; other site 266835012430 Q-loop/lid; other site 266835012431 ABC transporter signature motif; other site 266835012432 Walker B; other site 266835012433 D-loop; other site 266835012434 H-loop/switch region; other site 266835012435 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 266835012436 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 266835012437 putative ligand binding site [chemical binding]; other site 266835012438 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835012439 Helix-turn-helix domains; Region: HTH; cl00088 266835012440 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835012441 dimerization interface [polypeptide binding]; other site 266835012442 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835012443 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 266835012444 Helix-turn-helix domains; Region: HTH; cl00088 266835012445 OpgC protein; Region: OpgC_C; cl00792 266835012446 Acyltransferase family; Region: Acyl_transf_3; pfam01757 266835012447 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 266835012448 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 266835012449 Ligand binding site; other site 266835012450 Putative Catalytic site; other site 266835012451 DXD motif; other site 266835012452 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 266835012453 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835012454 dimer interface [polypeptide binding]; other site 266835012455 phosphorylation site [posttranslational modification] 266835012456 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835012457 ATP binding site [chemical binding]; other site 266835012458 Mg2+ binding site [ion binding]; other site 266835012459 G-X-G motif; other site 266835012460 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835012461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835012462 active site 266835012463 phosphorylation site [posttranslational modification] 266835012464 intermolecular recognition site; other site 266835012465 dimerization interface [polypeptide binding]; other site 266835012466 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835012467 DNA binding site [nucleotide binding] 266835012468 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 266835012469 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 266835012470 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 266835012471 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 266835012472 MatE; Region: MatE; cl10513 266835012473 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 266835012474 quinone interaction residues [chemical binding]; other site 266835012475 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 266835012476 active site 266835012477 catalytic residues [active] 266835012478 FMN binding site [chemical binding]; other site 266835012479 substrate binding site [chemical binding]; other site 266835012480 Protein of unknown function (DUF952); Region: DUF952; cl01393 266835012481 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266835012482 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835012483 active site 266835012484 phosphorylation site [posttranslational modification] 266835012485 intermolecular recognition site; other site 266835012486 dimerization interface [polypeptide binding]; other site 266835012487 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835012488 DNA binding residues [nucleotide binding] 266835012489 dimerization interface [polypeptide binding]; other site 266835012490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835012491 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266835012492 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835012493 Helix-turn-helix domains; Region: HTH; cl00088 266835012494 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835012495 dimerization interface [polypeptide binding]; other site 266835012496 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835012497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835012498 putative substrate translocation pore; other site 266835012499 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 266835012500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835012501 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835012502 Helix-turn-helix domains; Region: HTH; cl00088 266835012503 Sodium:solute symporter family; Region: SSF; cl00456 266835012504 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 266835012505 PAS fold; Region: PAS_7; pfam12860 266835012506 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 266835012507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835012508 ATP binding site [chemical binding]; other site 266835012509 Mg2+ binding site [ion binding]; other site 266835012510 G-X-G motif; other site 266835012511 Response regulator receiver domain; Region: Response_reg; pfam00072 266835012512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835012513 active site 266835012514 phosphorylation site [posttranslational modification] 266835012515 intermolecular recognition site; other site 266835012516 dimerization interface [polypeptide binding]; other site 266835012517 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 266835012518 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 266835012519 aspartate aminotransferase; Provisional; Region: PRK06108 266835012520 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835012521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835012522 homodimer interface [polypeptide binding]; other site 266835012523 catalytic residue [active] 266835012524 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 266835012525 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 266835012526 substrate-cofactor binding pocket; other site 266835012527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835012528 catalytic residue [active] 266835012529 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 266835012530 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 266835012531 NAD binding site [chemical binding]; other site 266835012532 homodimer interface [polypeptide binding]; other site 266835012533 active site 266835012534 substrate binding site [chemical binding]; other site 266835012535 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835012536 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835012537 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 266835012538 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 266835012539 active site 266835012540 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266835012541 dimer interface [polypeptide binding]; other site 266835012542 substrate binding site [chemical binding]; other site 266835012543 catalytic residue [active] 266835012544 Arginase family; Region: Arginase; cl00306 266835012545 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 266835012546 Novosphingobium aromaticivorans carbohydrate kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_NaCK_like; cd07772 266835012547 N- and C-terminal domain interface [polypeptide binding]; other site 266835012548 putative active site [active] 266835012549 putative MgATP binding site [chemical binding]; other site 266835012550 catalytic site [active] 266835012551 metal binding site [ion binding]; metal-binding site 266835012552 putative carbohydrate binding site [chemical binding]; other site 266835012553 Domain of unknown function (DUF718); Region: DUF718; cl01281 266835012554 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835012555 TM-ABC transporter signature motif; other site 266835012556 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835012557 TM-ABC transporter signature motif; other site 266835012558 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835012559 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 266835012560 Walker A/P-loop; other site 266835012561 ATP binding site [chemical binding]; other site 266835012562 Q-loop/lid; other site 266835012563 ABC transporter signature motif; other site 266835012564 Walker B; other site 266835012565 D-loop; other site 266835012566 H-loop/switch region; other site 266835012567 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 266835012568 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 266835012569 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 266835012570 ligand binding site [chemical binding]; other site 266835012571 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266835012572 Helix-turn-helix domains; Region: HTH; cl00088 266835012573 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 266835012574 short chain dehydrogenase; Validated; Region: PRK08324 266835012575 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 266835012576 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 266835012577 putative NAD(P) binding site [chemical binding]; other site 266835012578 active site 266835012579 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 266835012580 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 266835012581 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 266835012582 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 266835012583 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 266835012584 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835012585 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835012586 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266835012587 tetramerization interface [polypeptide binding]; other site 266835012588 NAD(P) binding site [chemical binding]; other site 266835012589 catalytic residues [active] 266835012590 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 266835012591 6-hydroxyhexanoate dehydrogenase (HHD) catalyzes the oxidation of 6-hydroxyhexanoate to 6-oxohexanoate; Region: HHD; cd08191 266835012592 putative active site [active] 266835012593 metal binding site [ion binding]; metal-binding site 266835012594 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835012595 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835012596 DNA-binding site [nucleotide binding]; DNA binding site 266835012597 FCD domain; Region: FCD; cl11656 266835012598 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 266835012599 conserved cys residue [active] 266835012600 conjugal transfer relaxase TraA; Provisional; Region: PRK13889 266835012601 MobA/MobL family; Region: MobA_MobL; pfam03389 266835012602 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835012603 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 266835012604 Protein of unknown function (DUF768); Region: DUF768; pfam05589 266835012605 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 266835012606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835012607 S-adenosylmethionine binding site [chemical binding]; other site 266835012608 CHASE3 domain; Region: CHASE3; cl05000 266835012609 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 266835012610 dimer interface [polypeptide binding]; other site 266835012611 phosphorylation site [posttranslational modification] 266835012612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835012613 ATP binding site [chemical binding]; other site 266835012614 Mg2+ binding site [ion binding]; other site 266835012615 G-X-G motif; other site 266835012616 Response regulator receiver domain; Region: Response_reg; pfam00072 266835012617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835012618 active site 266835012619 phosphorylation site [posttranslational modification] 266835012620 intermolecular recognition site; other site 266835012621 dimerization interface [polypeptide binding]; other site 266835012622 Response regulator receiver domain; Region: Response_reg; pfam00072 266835012623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835012624 active site 266835012625 phosphorylation site [posttranslational modification] 266835012626 intermolecular recognition site; other site 266835012627 dimerization interface [polypeptide binding]; other site 266835012628 Histidine kinase; Region: HisKA_2; cl06527 266835012629 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835012630 ATP binding site [chemical binding]; other site 266835012631 Mg2+ binding site [ion binding]; other site 266835012632 G-X-G motif; other site 266835012633 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266835012634 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 266835012635 ligand binding site [chemical binding]; other site 266835012636 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835012637 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 266835012638 similar to Large-conductance mechanosensitive channel 266835012639 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 266835012640 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 266835012641 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 266835012642 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 266835012643 Integrase core domain; Region: rve; cl01316 266835012644 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 266835012645 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835012646 non-specific DNA binding site [nucleotide binding]; other site 266835012647 salt bridge; other site 266835012648 sequence-specific DNA binding site [nucleotide binding]; other site 266835012649 integrase; Provisional; Region: PRK09692 266835012650 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 266835012651 active site 266835012652 Int/Topo IB signature motif; other site 266835012653 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 266835012654 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 266835012655 PYR/PP interface [polypeptide binding]; other site 266835012656 dimer interface [polypeptide binding]; other site 266835012657 TPP binding site [chemical binding]; other site 266835012658 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266835012659 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 266835012660 TPP-binding site [chemical binding]; other site 266835012661 dimer interface [polypeptide binding]; other site 266835012662 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266835012663 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835012664 NAD(P) binding site [chemical binding]; other site 266835012665 active site 266835012666 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 266835012667 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266835012668 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_10; cd06319 266835012669 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266835012670 putative ligand binding site [chemical binding]; other site 266835012671 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835012672 TM-ABC transporter signature motif; other site 266835012673 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835012674 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 266835012675 Walker A/P-loop; other site 266835012676 ATP binding site [chemical binding]; other site 266835012677 Q-loop/lid; other site 266835012678 ABC transporter signature motif; other site 266835012679 Walker B; other site 266835012680 D-loop; other site 266835012681 H-loop/switch region; other site 266835012682 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 266835012683 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266835012684 Helix-turn-helix domains; Region: HTH; cl00088 266835012685 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266835012686 dimerization interface [polypeptide binding]; other site 266835012687 substrate binding pocket [chemical binding]; other site 266835012688 Helix-turn-helix domains; Region: HTH; cl00088 266835012689 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 266835012690 catalytic residues [active] 266835012691 hypothetical protein; Validated; Region: PRK09169 266835012692 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266835012693 putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916 266835012694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835012695 ATP binding site [chemical binding]; other site 266835012696 Mg2+ binding site [ion binding]; other site 266835012697 G-X-G motif; other site 266835012698 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835012699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835012700 active site 266835012701 phosphorylation site [posttranslational modification] 266835012702 intermolecular recognition site; other site 266835012703 dimerization interface [polypeptide binding]; other site 266835012704 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835012705 DNA binding site [nucleotide binding] 266835012706 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 266835012707 Protein export membrane protein; Region: SecD_SecF; cl14618 266835012708 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 266835012709 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266835012710 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266835012711 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 266835012712 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 266835012713 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 266835012714 GAF domain; Region: GAF; cl15785 266835012715 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 266835012716 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835012717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835012718 homodimer interface [polypeptide binding]; other site 266835012719 catalytic residue [active] 266835012720 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 266835012721 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266835012722 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 266835012723 dimer interface [polypeptide binding]; other site 266835012724 substrate binding site [chemical binding]; other site 266835012725 ATP binding site [chemical binding]; other site 266835012726 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 266835012727 thiamine phosphate binding site [chemical binding]; other site 266835012728 active site 266835012729 pyrophosphate binding site [ion binding]; other site 266835012730 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 266835012731 ThiS interaction site; other site 266835012732 putative active site [active] 266835012733 tetramer interface [polypeptide binding]; other site 266835012734 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 266835012735 thiS-thiF/thiG interaction site; other site 266835012736 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835012737 FAD dependent oxidoreductase; Region: DAO; pfam01266 266835012738 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835012739 ThiC family; Region: ThiC; cl08031 266835012740 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 266835012741 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 266835012742 active site 266835012743 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 266835012744 Ligand Binding Site [chemical binding]; other site 266835012745 Fic family protein [Function unknown]; Region: COG3177 266835012746 Fic/DOC family; Region: Fic; cl00960 266835012747 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 266835012748 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 266835012749 active site 266835012750 substrate binding site [chemical binding]; other site 266835012751 metal binding site [ion binding]; metal-binding site 266835012752 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 266835012753 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 266835012754 Substrate binding site; other site 266835012755 Cupin domain; Region: Cupin_2; cl09118 266835012756 restriction alleviation and modification protein; Reviewed; Region: lar; cl08047 266835012757 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 266835012758 Helix-turn-helix domains; Region: HTH; cl00088 266835012759 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835012760 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266835012761 tetramerization interface [polypeptide binding]; other site 266835012762 NAD(P) binding site [chemical binding]; other site 266835012763 catalytic residues [active] 266835012764 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 266835012765 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 266835012766 ring oligomerisation interface [polypeptide binding]; other site 266835012767 ATP/Mg binding site [chemical binding]; other site 266835012768 stacking interactions; other site 266835012769 hinge regions; other site 266835012770 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 266835012771 oligomerisation interface [polypeptide binding]; other site 266835012772 mobile loop; other site 266835012773 roof hairpin; other site 266835012774 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 266835012775 N-acetyltransferase; Region: Acetyltransf_2; cl00949 266835012776 coproporphyrinogen III oxidase; Provisional; Region: PRK13347 266835012777 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835012778 FeS/SAM binding site; other site 266835012779 HemN C-terminal domain; Region: HemN_C; pfam06969 266835012780 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 266835012781 Prolyl oligopeptidase, N-terminal beta-propeller domain; Region: Peptidase_S9_N; pfam02897 266835012782 Phosphopantetheine attachment site; Region: PP-binding; cl09936 266835012783 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 266835012784 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 266835012785 dimer interface [polypeptide binding]; other site 266835012786 active site 266835012787 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835012788 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 266835012789 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cl00540 266835012790 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05963 266835012791 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 266835012792 dimer interface [polypeptide binding]; other site 266835012793 active site 266835012794 CoA binding pocket [chemical binding]; other site 266835012795 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 266835012796 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835012797 inhibitor-cofactor binding pocket; inhibition site 266835012798 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835012799 catalytic residue [active] 266835012800 AAA domain; Region: AAA_26; pfam13500 266835012801 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835012802 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 266835012803 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266835012804 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835012805 catalytic residue [active] 266835012806 biotin synthase; Region: bioB; TIGR00433 266835012807 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835012808 FeS/SAM binding site; other site 266835012809 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 266835012810 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 266835012811 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 266835012812 dimerization interface [polypeptide binding]; other site 266835012813 active site 266835012814 L-aspartate oxidase; Provisional; Region: PRK07512 266835012815 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835012816 domain; Region: Succ_DH_flav_C; pfam02910 266835012817 Quinolinate synthetase A protein; Region: NadA; cl00420 266835012818 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 266835012819 Nif-specific regulatory protein; Region: nifA; TIGR01817 266835012820 GAF domain; Region: GAF; cl15785 266835012821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835012822 Walker A motif; other site 266835012823 ATP binding site [chemical binding]; other site 266835012824 Walker B motif; other site 266835012825 arginine finger; other site 266835012826 Helix-turn-helix domains; Region: HTH; cl00088 266835012827 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266835012828 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835012829 DNA binding site [nucleotide binding] 266835012830 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 266835012831 putative ligand binding site [chemical binding]; other site 266835012832 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 266835012833 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 266835012834 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835012835 dimer interface [polypeptide binding]; other site 266835012836 phosphorylation site [posttranslational modification] 266835012837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835012838 ATP binding site [chemical binding]; other site 266835012839 Mg2+ binding site [ion binding]; other site 266835012840 G-X-G motif; other site 266835012841 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 266835012842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835012843 active site 266835012844 phosphorylation site [posttranslational modification] 266835012845 intermolecular recognition site; other site 266835012846 dimerization interface [polypeptide binding]; other site 266835012847 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835012848 Walker A motif; other site 266835012849 ATP binding site [chemical binding]; other site 266835012850 Walker B motif; other site 266835012851 arginine finger; other site 266835012852 Helix-turn-helix domains; Region: HTH; cl00088 266835012853 Integrase core domain; Region: rve_3; cl15866 266835012854 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835012855 Nodulation protein Z (NodZ); Region: NodZ; pfam05830 266835012856 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 266835012857 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 266835012858 NADP-binding site; other site 266835012859 homotetramer interface [polypeptide binding]; other site 266835012860 substrate binding site [chemical binding]; other site 266835012861 homodimer interface [polypeptide binding]; other site 266835012862 active site 266835012863 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 266835012864 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 266835012865 NADP binding site [chemical binding]; other site 266835012866 active site 266835012867 putative substrate binding site [chemical binding]; other site 266835012868 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 266835012869 NifT/FixU protein; Region: NifT; cl02351 266835012870 NifZ domain; Region: NifZ; pfam04319 266835012871 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 266835012872 hypothetical protein; Provisional; Region: PRK13795 266835012873 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 266835012874 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835012875 FeS/SAM binding site; other site 266835012876 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 266835012877 Nif-specific regulatory protein; Region: nifA; TIGR01817 266835012878 GAF domain; Region: GAF; cl00853 266835012879 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835012880 Walker A motif; other site 266835012881 ATP binding site [chemical binding]; other site 266835012882 Walker B motif; other site 266835012883 arginine finger; other site 266835012884 Helix-turn-helix domains; Region: HTH; cl00088 266835012885 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 266835012886 oxidoreductase; Provisional; Region: PRK10015 266835012887 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835012888 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 266835012889 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 266835012890 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 266835012891 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 266835012892 Ligand binding site [chemical binding]; other site 266835012893 Electron transfer flavoprotein domain; Region: ETF; pfam01012 266835012894 Nitrogen fixation protein NifW; Region: NifW; cl03935 266835012895 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266835012896 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 266835012897 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835012898 catalytic residue [active] 266835012899 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266835012900 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 266835012901 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 266835012902 Walker A/P-loop; other site 266835012903 ATP binding site [chemical binding]; other site 266835012904 Q-loop/lid; other site 266835012905 ABC transporter signature motif; other site 266835012906 Walker B; other site 266835012907 D-loop; other site 266835012908 H-loop/switch region; other site 266835012909 Protein of unknown function (DUF683); Region: DUF683; cl02247 266835012910 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 266835012911 NifQ; Region: NifQ; pfam04891 266835012912 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 266835012913 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 266835012914 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 266835012915 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 266835012916 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 266835012917 catalytic triad [active] 266835012918 dimer interface [polypeptide binding]; other site 266835012919 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 266835012920 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 266835012921 classical (c) SDRs; Region: SDR_c; cd05233 266835012922 NAD(P) binding site [chemical binding]; other site 266835012923 active site 266835012924 classical (c) SDRs; Region: SDR_c; cd05233 266835012925 NAD(P) binding site [chemical binding]; other site 266835012926 classical (c) SDRs; Region: SDR_c; cd05233 266835012927 active site 266835012928 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266835012929 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 266835012930 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 266835012931 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266835012932 tetramer interface [polypeptide binding]; other site 266835012933 active site 266835012934 Mg2+/Mn2+ binding site [ion binding]; other site 266835012935 aspartate aminotransferase; Provisional; Region: PRK05764 266835012936 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835012937 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835012938 homodimer interface [polypeptide binding]; other site 266835012939 catalytic residue [active] 266835012940 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 266835012941 active site 266835012942 metal-binding site 266835012943 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 266835012944 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835012945 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 266835012946 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 266835012947 active site 266835012948 dimer interface [polypeptide binding]; other site 266835012949 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 266835012950 Ligand Binding Site [chemical binding]; other site 266835012951 Molecular Tunnel; other site 266835012952 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 266835012953 Sulfatase; Region: Sulfatase; cl10460 266835012954 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 266835012955 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835012956 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835012957 homodimer interface [polypeptide binding]; other site 266835012958 catalytic residue [active] 266835012959 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266835012960 Helix-turn-helix domains; Region: HTH; cl00088 266835012961 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 266835012962 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835012963 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 266835012964 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266835012965 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835012966 Walker A/P-loop; other site 266835012967 ATP binding site [chemical binding]; other site 266835012968 Q-loop/lid; other site 266835012969 ABC transporter signature motif; other site 266835012970 Walker B; other site 266835012971 D-loop; other site 266835012972 H-loop/switch region; other site 266835012973 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835012974 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 266835012975 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835012976 Walker A/P-loop; other site 266835012977 ATP binding site [chemical binding]; other site 266835012978 Q-loop/lid; other site 266835012979 ABC transporter signature motif; other site 266835012980 Walker B; other site 266835012981 D-loop; other site 266835012982 H-loop/switch region; other site 266835012983 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835012984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835012985 dimer interface [polypeptide binding]; other site 266835012986 conserved gate region; other site 266835012987 putative PBP binding loops; other site 266835012988 ABC-ATPase subunit interface; other site 266835012989 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266835012990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835012991 dimer interface [polypeptide binding]; other site 266835012992 conserved gate region; other site 266835012993 putative PBP binding loops; other site 266835012994 ABC-ATPase subunit interface; other site 266835012995 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835012996 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 266835012997 Predicted transcriptional regulator [Transcription]; Region: COG5340 266835012998 diacylglycerol kinase; Reviewed; Region: PRK11914 266835012999 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 266835013000 oligomeric interface; other site 266835013001 putative active site [active] 266835013002 homodimer interface [polypeptide binding]; other site 266835013003 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835013004 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 266835013005 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 266835013006 Nucleotide-binding sites [chemical binding]; other site 266835013007 Walker A motif; other site 266835013008 Switch I region of nucleotide binding site; other site 266835013009 Fe4S4 binding sites [ion binding]; other site 266835013010 Switch II region of nucleotide binding site; other site 266835013011 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 266835013012 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 266835013013 MoFe protein alpha/beta subunit interactions; other site 266835013014 Alpha subunit P cluster binding residues; other site 266835013015 FeMoco binding residues [chemical binding]; other site 266835013016 MoFe protein alpha subunit/Fe protein contacts; other site 266835013017 MoFe protein dimer/ dimer interactions; other site 266835013018 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 266835013019 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 266835013020 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 266835013021 MoFe protein beta/alpha subunit interactions; other site 266835013022 Beta subunit P cluster binding residues; other site 266835013023 MoFe protein beta subunit/Fe protein contacts; other site 266835013024 MoFe protein dimer/ dimer interactions; other site 266835013025 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 266835013026 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 266835013027 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 266835013028 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 266835013029 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 266835013030 Protein of unknown function, DUF269; Region: DUF269; cl03973 266835013031 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835013032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835013033 active site 266835013034 phosphorylation site [posttranslational modification] 266835013035 intermolecular recognition site; other site 266835013036 dimerization interface [polypeptide binding]; other site 266835013037 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835013038 DNA binding site [nucleotide binding] 266835013039 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266835013040 Ligand Binding Site [chemical binding]; other site 266835013041 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835013042 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835013043 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266835013044 active site 266835013045 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 266835013046 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835013047 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 266835013048 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 266835013049 Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: MetG; COG0143 266835013050 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266835013051 active site 266835013052 HIGH motif; other site 266835013053 nucleotide binding site [chemical binding]; other site 266835013054 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266835013055 active site 266835013056 KMSKS motif; other site 266835013057 Rop-like; Region: Rop-like; cl02247 266835013058 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 266835013059 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 266835013060 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 266835013061 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835013062 catalytic residue [active] 266835013063 similar to Transcriptional regulator 266835013064 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 266835013065 Ligand Binding Site [chemical binding]; other site 266835013066 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 266835013067 active site 266835013068 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 266835013069 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835013070 FeS/SAM binding site; other site 266835013071 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 266835013072 trimerization site [polypeptide binding]; other site 266835013073 active site 266835013074 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 266835013075 diaminobutyrate--2-oxoglutarate aminotransferase; Region: ectoine_ectB; TIGR02407 266835013076 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835013077 inhibitor-cofactor binding pocket; inhibition site 266835013078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835013079 catalytic residue [active] 266835013080 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 266835013081 Helix-turn-helix domains; Region: HTH; cl00088 266835013082 HTH-like domain; Region: HTH_21; pfam13276 266835013083 Transposase domain (DUF772); Region: DUF772; cl15789 266835013084 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 266835013085 Integrase core domain; Region: rve; cl01316 266835013086 Autoinducer binding domain; Region: Autoind_bind; pfam03472 266835013087 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835013088 DNA binding residues [nucleotide binding] 266835013089 dimerization interface [polypeptide binding]; other site 266835013090 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 266835013091 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 266835013092 Int/Topo IB signature motif; other site 266835013093 INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187 266835013094 Int/Topo IB signature motif; other site 266835013095 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 266835013096 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 266835013097 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 266835013098 Int/Topo IB signature motif; other site 266835013099 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 266835013100 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 266835013101 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 266835013102 Transposase; Region: DDE_Tnp_ISL3; pfam01610 266835013103 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 266835013104 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 266835013105 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835013106 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835013107 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835013108 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835013109 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835013110 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835013111 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835013112 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835013113 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 266835013114 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 266835013115 Transposase, Mutator family; Region: Transposase_mut; pfam00872 266835013116 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266835013117 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266835013118 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266835013119 active site 266835013120 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 266835013121 KamA family protein; Region: TIGR00238; cl15377 266835013122 Helix-turn-helix domains; Region: HTH; cl00088 266835013123 HTH-like domain; Region: HTH_21; pfam13276 266835013124 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266835013125 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266835013126 DNA binding site [nucleotide binding] 266835013127 active site 266835013128 Int/Topo IB signature motif; other site 266835013129 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 266835013130 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835013131 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835013132 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 266835013133 DDE superfamily endonuclease; Region: DDE_5; cl02413 266835013134 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835013135 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835013136 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835013137 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835013138 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835013139 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835013140 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 266835013141 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835013142 Coenzyme A binding pocket [chemical binding]; other site 266835013143 putative aminotransferase; Validated; Region: PRK07480 266835013144 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835013145 inhibitor-cofactor binding pocket; inhibition site 266835013146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835013147 catalytic residue [active] 266835013148 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 266835013149 MlrC C-terminus; Region: MlrC_C; pfam07171 266835013150 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266835013151 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266835013152 putative active site [active] 266835013153 hypothetical protein; Provisional; Region: PRK07483 266835013154 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835013155 inhibitor-cofactor binding pocket; inhibition site 266835013156 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835013157 catalytic residue [active] 266835013158 Transposase, Mutator family; Region: Transposase_mut; pfam00872 266835013159 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835013160 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835013161 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835013162 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 266835013163 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 266835013164 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835013165 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266835013166 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835013167 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: PLN02974 266835013168 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835013169 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266835013170 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835013171 catalytic residue [active] 266835013172 biotin synthase; Region: bioB; TIGR00433 266835013173 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835013174 FeS/SAM binding site; other site 266835013175 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 266835013176 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266835013177 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 266835013178 similar to Predicted acyl dehydratase 266835013179 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 266835013180 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266835013181 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 266835013182 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 266835013183 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266835013184 carboxyltransferase (CT) interaction site; other site 266835013185 biotinylation site [posttranslational modification]; other site 266835013186 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 266835013187 enoyl-CoA hydratase; Provisional; Region: PRK08252 266835013188 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835013189 substrate binding site [chemical binding]; other site 266835013190 oxyanion hole (OAH) forming residues; other site 266835013191 trimer interface [polypeptide binding]; other site 266835013192 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 266835013193 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 266835013194 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 266835013195 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 266835013196 metal binding site [ion binding]; metal-binding site 266835013197 putative dimer interface [polypeptide binding]; other site 266835013198 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266835013199 Methylaspartate ammonia-lyase N-terminus; Region: MAAL_N; pfam05034 266835013200 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 266835013201 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835013202 inhibitor-cofactor binding pocket; inhibition site 266835013203 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835013204 catalytic residue [active] 266835013205 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266835013206 Phosphotransferase enzyme family; Region: APH; pfam01636 266835013207 active site 266835013208 ATP binding site [chemical binding]; other site 266835013209 substrate binding site [chemical binding]; other site 266835013210 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266835013211 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266835013212 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266835013213 active site 266835013214 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 266835013215 Transposase domain (DUF772); Region: DUF772; cl15789 266835013216 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835013217 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835013218 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 266835013219 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 266835013220 Integrase core domain; Region: rve; cl01316 266835013221 transposase; Validated; Region: PRK08181 266835013222 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835013223 Walker A motif; other site 266835013224 ATP binding site [chemical binding]; other site 266835013225 Walker B motif; other site 266835013226 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266835013227 Phage integrase family; Region: Phage_integrase; pfam00589 266835013228 DNA binding site [nucleotide binding] 266835013229 Int/Topo IB signature motif; other site 266835013230 active site 266835013231 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266835013232 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266835013233 active site 266835013234 Int/Topo IB signature motif; other site 266835013235 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 266835013236 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 266835013237 Int/Topo IB signature motif; other site 266835013238 INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187 266835013239 Int/Topo IB signature motif; other site 266835013240 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 266835013241 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 266835013242 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 266835013243 Int/Topo IB signature motif; other site 266835013244 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266835013245 Int/Topo IB signature motif; other site 266835013246 active site 266835013247 DNA binding site [nucleotide binding] 266835013248 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 266835013249 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835013250 Walker A motif; other site 266835013251 ATP binding site [chemical binding]; other site 266835013252 Walker B motif; other site 266835013253 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 266835013254 Winged helix-turn helix; Region: HTH_29; pfam13551 266835013255 Helix-turn-helix domains; Region: HTH; cl00088 266835013256 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 266835013257 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 266835013258 catalytic residues [active] 266835013259 catalytic nucleophile [active] 266835013260 Recombinase; Region: Recombinase; pfam07508 266835013261 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835013262 DNA binding residues [nucleotide binding] 266835013263 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 266835013264 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835013265 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835013266 Helix-turn-helix domains; Region: HTH; cl00088 266835013267 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 266835013268 MlrC C-terminus; Region: MlrC_C; pfam07171 266835013269 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 266835013270 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 266835013271 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 266835013272 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835013273 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835013274 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835013275 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835013276 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835013277 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835013278 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835013279 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835013280 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835013281 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835013282 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 266835013283 active site 266835013284 enoyl-CoA hydratase; Provisional; Region: PRK08252 266835013285 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835013286 substrate binding site [chemical binding]; other site 266835013287 oxyanion hole (OAH) forming residues; other site 266835013288 trimer interface [polypeptide binding]; other site 266835013289 Transposase domain (DUF772); Region: DUF772; cl15789 266835013290 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 266835013291 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 266835013292 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835013293 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835013294 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835013295 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835013296 Walker A/P-loop; other site 266835013297 ATP binding site [chemical binding]; other site 266835013298 Q-loop/lid; other site 266835013299 ABC transporter signature motif; other site 266835013300 Walker B; other site 266835013301 D-loop; other site 266835013302 H-loop/switch region; other site 266835013303 TOBE domain; Region: TOBE_2; cl01440 266835013304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835013305 dimer interface [polypeptide binding]; other site 266835013306 conserved gate region; other site 266835013307 putative PBP binding loops; other site 266835013308 ABC-ATPase subunit interface; other site 266835013309 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835013310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835013311 dimer interface [polypeptide binding]; other site 266835013312 conserved gate region; other site 266835013313 putative PBP binding loops; other site 266835013314 ABC-ATPase subunit interface; other site 266835013315 putative amidase; Provisional; Region: PRK06169 266835013316 Amidase; Region: Amidase; cl11426 266835013317 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835013318 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 266835013319 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835013320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835013321 dimer interface [polypeptide binding]; other site 266835013322 conserved gate region; other site 266835013323 putative PBP binding loops; other site 266835013324 ABC-ATPase subunit interface; other site 266835013325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835013326 dimer interface [polypeptide binding]; other site 266835013327 conserved gate region; other site 266835013328 putative PBP binding loops; other site 266835013329 ABC-ATPase subunit interface; other site 266835013330 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266835013331 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835013332 Walker A/P-loop; other site 266835013333 ATP binding site [chemical binding]; other site 266835013334 Q-loop/lid; other site 266835013335 ABC transporter signature motif; other site 266835013336 Walker B; other site 266835013337 D-loop; other site 266835013338 H-loop/switch region; other site 266835013339 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835013340 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 266835013341 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835013342 Walker A/P-loop; other site 266835013343 ATP binding site [chemical binding]; other site 266835013344 Q-loop/lid; other site 266835013345 ABC transporter signature motif; other site 266835013346 Walker B; other site 266835013347 D-loop; other site 266835013348 H-loop/switch region; other site 266835013349 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835013350 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 266835013351 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835013352 putative transposase OrfB; Reviewed; Region: PHA02517 266835013353 HTH-like domain; Region: HTH_21; pfam13276 266835013354 Integrase core domain; Region: rve; cl01316 266835013355 Integrase core domain; Region: rve_3; cl15866 266835013356 Helix-turn-helix domains; Region: HTH; cl00088 266835013357 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835013358 Predicted deacylase [General function prediction only]; Region: COG3608 266835013359 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 266835013360 putative active site [active] 266835013361 Zn binding site [ion binding]; other site 266835013362 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 266835013363 Zn binding site [ion binding]; other site 266835013364 methylaspartate ammonia-lyase; Region: B_methylAsp_ase; TIGR01502 266835013365 Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314 266835013366 dimer interface [polypeptide binding]; other site 266835013367 active site 266835013368 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266835013369 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266835013370 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 266835013371 Helix-turn-helix domains; Region: HTH; cl00088 266835013372 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 266835013373 putative dimerization interface [polypeptide binding]; other site 266835013374 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835013375 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266835013376 tetramerization interface [polypeptide binding]; other site 266835013377 NAD(P) binding site [chemical binding]; other site 266835013378 catalytic residues [active] 266835013379 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 266835013380 Fumarase C-terminus; Region: Fumerase_C; cl00795 266835013381 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835013382 Helix-turn-helix domains; Region: HTH; cl00088 266835013383 hypothetical protein; Provisional; Region: PRK07482 266835013384 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835013385 inhibitor-cofactor binding pocket; inhibition site 266835013386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835013387 catalytic residue [active] 266835013388 transcriptional regulator TraR; Provisional; Region: PRK13870 266835013389 Autoinducer binding domain; Region: Autoind_bind; pfam03472 266835013390 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835013391 DNA binding residues [nucleotide binding] 266835013392 dimerization interface [polypeptide binding]; other site 266835013393 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835013394 Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246 266835013395 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835013396 non-specific DNA binding site [nucleotide binding]; other site 266835013397 salt bridge; other site 266835013398 sequence-specific DNA binding site [nucleotide binding]; other site 266835013399 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835013400 sequence-specific DNA binding site [nucleotide binding]; other site 266835013401 salt bridge; other site 266835013402 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 266835013403 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835013404 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835013405 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835013406 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 266835013407 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 266835013408 dimer interface [polypeptide binding]; other site 266835013409 glycine-pyridoxal phosphate binding site [chemical binding]; other site 266835013410 active site 266835013411 folate binding site [chemical binding]; other site 266835013412 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 266835013413 S-adenosylmethionine synthetase; Validated; Region: PRK05250 266835013414 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 266835013415 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 266835013416 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine...; Region: adenosine_kinase; cd01168 266835013417 substrate binding site [chemical binding]; other site 266835013418 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 266835013419 ATP binding site [chemical binding]; other site 266835013420 substrate binding site [chemical binding]; other site 266835013421 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 266835013422 DNA-binding site [nucleotide binding]; DNA binding site 266835013423 RNA-binding motif; other site 266835013424 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; cl11561 266835013425 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 266835013426 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 266835013427 THF binding site; other site 266835013428 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 266835013429 substrate binding site [chemical binding]; other site 266835013430 THF binding site; other site 266835013431 zinc-binding site [ion binding]; other site 266835013432 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 266835013433 Cytochrome P450; Region: p450; cl12078 266835013434 Surface antigen; Region: Surface_Ag_2; cl01155 266835013435 Transposase domain (DUF772); Region: DUF772; cl15789 266835013436 Cupin domain; Region: Cupin_2; cl09118 266835013437 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266835013438 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 266835013439 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 266835013440 tetramer interface [polypeptide binding]; other site 266835013441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835013442 catalytic residue [active] 266835013443 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 266835013444 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835013445 Coenzyme A binding pocket [chemical binding]; other site 266835013446 Omptin family; Region: Omptin; cl01886 266835013447 Domain of unknown function (DUF955); Region: DUF955; cl01076 266835013448 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 266835013449 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 266835013450 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 266835013451 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 266835013452 hypothetical protein; Provisional; Region: PRK06153 266835013453 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 266835013454 ATP binding site [chemical binding]; other site 266835013455 substrate interface [chemical binding]; other site 266835013456 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266835013457 Transposase domain (DUF772); Region: DUF772; cl12084 266835013458 OpgC protein; Region: OpgC_C; cl00792 266835013459 Integrase core domain; Region: rve; cl01316 266835013460 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 266835013461 Helix-turn-helix domains; Region: HTH; cl00088 266835013462 putative transposase OrfB; Reviewed; Region: PHA02517 266835013463 Integrase core domain; Region: rve; cl01316 266835013464 Transposase, Mutator family; Region: Transposase_mut; pfam00872 266835013465 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266835013466 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266835013467 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266835013468 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 266835013469 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 266835013470 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 266835013471 ParB-like nuclease domain; Region: ParBc; cl02129 266835013472 PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734 266835013473 hypothetical protein; Provisional; Region: PRK09126 266835013474 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835013475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835013476 S-adenosylmethionine binding site [chemical binding]; other site 266835013477 Nodulation protein A (NodA); Region: NodA; cl03608 266835013478 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 266835013479 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 266835013480 DXD motif; other site 266835013481 nodulation factor exporter subunit NodI; Provisional; Region: PRK13536 266835013482 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 266835013483 Walker A/P-loop; other site 266835013484 ATP binding site [chemical binding]; other site 266835013485 Q-loop/lid; other site 266835013486 ABC transporter signature motif; other site 266835013487 Walker B; other site 266835013488 D-loop; other site 266835013489 H-loop/switch region; other site 266835013490 ABC-2 type transporter; Region: ABC2_membrane; cl11417 266835013491 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 266835013492 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 266835013493 Nodulation protein Z (NodZ); Region: NodZ; pfam05830 266835013494 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266835013495 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266835013496 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835013497 DNA-binding site [nucleotide binding]; DNA binding site 266835013498 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835013499 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835013500 homodimer interface [polypeptide binding]; other site 266835013501 catalytic residue [active] 266835013502 Putative catalytic domain of rhizobial NodB chitooligosaccharide N-deacetylase and its bacterial homologs; Region: CE4_NodB; cd10943 266835013503 NodB motif; other site 266835013504 putative active site [active] 266835013505 putative catalytic site [active] 266835013506 putative Zn binding site [ion binding]; other site 266835013507 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 266835013508 LysE type translocator; Region: LysE; cl00565 266835013509 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 266835013510 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835013511 Helix-turn-helix domains; Region: HTH; cl00088 266835013512 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835013513 dimerization interface [polypeptide binding]; other site 266835013514 OpgC protein; Region: OpgC_C; cl00792 266835013515 Acyltransferase family; Region: Acyl_transf_3; pfam01757 266835013516 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835013517 Helix-turn-helix domains; Region: HTH; cl00088 266835013518 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835013519 dimerization interface [polypeptide binding]; other site 266835013520 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266835013521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835013522 putative substrate translocation pore; other site 266835013523 transcriptional regulator SlyA; Provisional; Region: PRK03573 266835013524 Protein of unknown function (DUF736); Region: DUF736; cl02303 266835013525 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 266835013526 Type IV secretory pathway, protease TraF [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: TraF; COG4959 266835013527 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 266835013528 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 266835013529 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266835013530 catalytic residue [active] 266835013531 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835013532 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835013533 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584 266835013534 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 266835013535 Prokaryotic E2 family C; Region: Prok-E2_C; pfam14459 266835013536 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 266835013537 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 266835013538 ATP binding site [chemical binding]; other site 266835013539 substrate interface [chemical binding]; other site 266835013540 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 266835013541 Predicted metal binding domain; Region: Metal_CEHH; pfam14455 266835013542 Protein of Unknown function (DUF2604); Region: DUF2604; pfam10790 266835013543 Protein of unknown function (DUF1403); Region: DUF1403; pfam07183 266835013544 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 266835013545 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 266835013546 Piwi_piwi-like_ProArk: PIWI domain, Piwi-like subfamily found in Archaea and Bacteria. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs; Region: Piwi_piwi-like_ProArk; cd04659 266835013547 5' RNA guide strand anchoring site; other site 266835013548 active site 266835013549 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 266835013550 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 266835013551 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 266835013552 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 266835013553 substrate binding pocket [chemical binding]; other site 266835013554 dimer interface [polypeptide binding]; other site 266835013555 inhibitor binding site; inhibition site 266835013556 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 266835013557 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 266835013558 MatE; Region: MatE; cl10513 266835013559 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 266835013560 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266835013561 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835013562 catalytic residue [active] 266835013563 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 266835013564 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266835013565 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 266835013566 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 266835013567 active site 266835013568 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266835013569 dimer interface [polypeptide binding]; other site 266835013570 substrate binding site [chemical binding]; other site 266835013571 catalytic residues [active] 266835013572 Integrase core domain; Region: rve; cl01316 266835013573 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 266835013574 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266835013575 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266835013576 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266835013577 active site 266835013578 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 266835013579 Transposase domain (DUF772); Region: DUF772; cl15789 266835013580 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835013581 transposase; Validated; Region: PRK08181 266835013582 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 266835013583 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 266835013584 catalytic residues [active] 266835013585 catalytic nucleophile [active] 266835013586 Recombinase; Region: Recombinase; pfam07508 266835013587 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 266835013588 Recombinase; Region: Recombinase; pfam07508 266835013589 transposase; Validated; Region: PRK08181 266835013590 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835013591 Walker A motif; other site 266835013592 ATP binding site [chemical binding]; other site 266835013593 Walker B motif; other site 266835013594 Integrase core domain; Region: rve; cl01316 266835013595 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 266835013596 Transposase domain (DUF772); Region: DUF772; cl12084 266835013597 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 266835013598 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835013599 S-adenosylmethionine binding site [chemical binding]; other site 266835013600 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835013601 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 266835013602 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 266835013603 Int/Topo IB signature motif; other site 266835013604 INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187 266835013605 Int/Topo IB signature motif; other site 266835013606 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 266835013607 Int/Topo IB signature motif; other site 266835013608 transposase; Validated; Region: PRK08181 266835013609 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835013610 Walker A motif; other site 266835013611 ATP binding site [chemical binding]; other site 266835013612 Walker B motif; other site 266835013613 Integrase core domain; Region: rve; cl01316 266835013614 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266835013615 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 266835013616 conserved cys residue [active] 266835013617 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835013618 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 266835013619 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 266835013620 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 266835013621 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835013622 Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767 266835013623 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835013624 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835013625 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266835013626 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 266835013627 conserved cys residue [active] 266835013628 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835013629 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 266835013630 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266835013631 Helix-turn-helix domains; Region: HTH; cl00088 266835013632 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266835013633 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 266835013634 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 266835013635 Integrase core domain; Region: rve; cl01316 266835013636 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 266835013637 Domain of unknown function (DUF4084); Region: DUF4084; pfam13321 266835013638 tyramine oxidase; Provisional; Region: tynA; PRK11504 266835013639 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 266835013640 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 266835013641 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 266835013642 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 266835013643 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 266835013644 catalytic triad [active] 266835013645 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 266835013646 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 266835013647 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 266835013648 catalytic triad [active] 266835013649 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266835013650 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266835013651 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266835013652 active site 266835013653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835013654 dimer interface [polypeptide binding]; other site 266835013655 conserved gate region; other site 266835013656 putative PBP binding loops; other site 266835013657 ABC-ATPase subunit interface; other site 266835013658 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835013659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835013660 dimer interface [polypeptide binding]; other site 266835013661 conserved gate region; other site 266835013662 putative PBP binding loops; other site 266835013663 ABC-ATPase subunit interface; other site 266835013664 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835013665 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 266835013666 Walker A/P-loop; other site 266835013667 ATP binding site [chemical binding]; other site 266835013668 Q-loop/lid; other site 266835013669 ABC transporter signature motif; other site 266835013670 Walker B; other site 266835013671 D-loop; other site 266835013672 H-loop/switch region; other site 266835013673 TOBE domain; Region: TOBE_2; cl01440 266835013674 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835013675 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835013676 Helix-turn-helix domains; Region: HTH; cl00088 266835013677 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266835013678 Bacterial transcriptional regulator; Region: IclR; pfam01614 266835013679 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 266835013680 DNA-binding site [nucleotide binding]; DNA binding site 266835013681 RNA-binding motif; other site 266835013682 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; cl11561 266835013683 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 266835013684 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835013685 non-specific DNA binding site [nucleotide binding]; other site 266835013686 salt bridge; other site 266835013687 sequence-specific DNA binding site [nucleotide binding]; other site 266835013688 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 266835013689 AAA domain; Region: AAA_26; pfam13500 266835013690 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835013691 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 266835013692 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 266835013693 dimerization interface [polypeptide binding]; other site 266835013694 active site 266835013695 L-aspartate oxidase; Provisional; Region: PRK07512 266835013696 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 266835013697 Helix-turn-helix domains; Region: HTH; cl00088 266835013698 Integrase core domain; Region: rve; cl01316 266835013699 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 266835013700 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835013701 AAA domain; Region: AAA_22; pfam13401 266835013702 TniQ; Region: TniQ; pfam06527 266835013703 Transposase, Mutator family; Region: Transposase_mut; pfam00872 266835013704 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 266835013705 MULE transposase domain; Region: MULE; pfam10551 266835013706 Integrase core domain; Region: rve; cl01316 266835013707 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266835013708 AMP-binding enzyme; Region: AMP-binding; cl15778 266835013709 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 266835013710 Cupin domain; Region: Cupin_2; cl09118 266835013711 L-proline 3-hydroxylase, C-terminal; Region: Pro_3_hydrox_C; pfam05373 266835013712 Bacterial protein of unknown function (DUF894); Region: DUF894; pfam05977 266835013713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835013714 putative substrate translocation pore; other site 266835013715 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835013716 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835013717 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835013718 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266835013719 active site 266835013720 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 266835013721 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835013722 Walker A/P-loop; other site 266835013723 ATP binding site [chemical binding]; other site 266835013724 Q-loop/lid; other site 266835013725 ABC transporter signature motif; other site 266835013726 Walker B; other site 266835013727 D-loop; other site 266835013728 H-loop/switch region; other site 266835013729 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835013730 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835013731 Walker A/P-loop; other site 266835013732 ATP binding site [chemical binding]; other site 266835013733 Q-loop/lid; other site 266835013734 ABC transporter signature motif; other site 266835013735 Walker B; other site 266835013736 D-loop; other site 266835013737 H-loop/switch region; other site 266835013738 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835013739 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835013740 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 266835013741 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835013742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835013743 dimer interface [polypeptide binding]; other site 266835013744 conserved gate region; other site 266835013745 putative PBP binding loops; other site 266835013746 ABC-ATPase subunit interface; other site 266835013747 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266835013748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835013749 ABC-ATPase subunit interface; other site 266835013750 putative PBP binding loops; other site 266835013751 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835013752 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835013753 DNA-binding site [nucleotide binding]; DNA binding site 266835013754 FCD domain; Region: FCD; cl11656 266835013755 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266835013756 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 266835013757 inhibitor site; inhibition site 266835013758 active site 266835013759 dimer interface [polypeptide binding]; other site 266835013760 catalytic residue [active] 266835013761 Uncharacterized conserved protein [Function unknown]; Region: COG5476 266835013762 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 266835013763 MlrC C-terminus; Region: MlrC_C; pfam07171 266835013764 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 266835013765 ATP-grasp domain; Region: ATP-grasp_4; cl03087 266835013766 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 266835013767 nucleotide binding site [chemical binding]; other site 266835013768 homotetrameric interface [polypeptide binding]; other site 266835013769 putative phosphate binding site [ion binding]; other site 266835013770 putative allosteric binding site; other site 266835013771 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835013772 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835013773 DNA-binding site [nucleotide binding]; DNA binding site 266835013774 FCD domain; Region: FCD; cl11656 266835013775 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 266835013776 Integrase core domain; Region: rve; cl01316 266835013777 Integrase core domain; Region: rve; cl01316 266835013778 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 266835013779 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 266835013780 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 266835013781 Protein of unknown function (DUF867); Region: DUF867; cl01713 266835013782 S1/P1 Nuclease; Region: S1-P1_nuclease; pfam02265 266835013783 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 266835013784 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 266835013785 putative active site [active] 266835013786 catalytic site [active] 266835013787 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 266835013788 putative active site [active] 266835013789 catalytic site [active] 266835013790 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 266835013791 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl08202 266835013792 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 266835013793 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 266835013794 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 266835013795 ST7 protein; Region: ST7; pfam04184 266835013796 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 266835013797 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 266835013798 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 266835013799 catalytic residues [active] 266835013800 catalytic nucleophile [active] 266835013801 Presynaptic Site I dimer interface [polypeptide binding]; other site 266835013802 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 266835013803 Synaptic Flat tetramer interface [polypeptide binding]; other site 266835013804 Synaptic Site I dimer interface [polypeptide binding]; other site 266835013805 DNA binding site [nucleotide binding] 266835013806 hypothetical protein; Validated; Region: PRK09169 266835013807 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 266835013808 ADP binding site [chemical binding]; other site 266835013809 magnesium binding site [ion binding]; other site 266835013810 putative shikimate binding site; other site 266835013811 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835013812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835013813 active site 266835013814 phosphorylation site [posttranslational modification] 266835013815 intermolecular recognition site; other site 266835013816 dimerization interface [polypeptide binding]; other site 266835013817 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835013818 DNA binding site [nucleotide binding] 266835013819 BON domain; Region: BON; cl02771 266835013820 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 266835013821 Type IV pili component [Cell motility and secretion]; Region: COG5461; cl02279 266835013822 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 266835013823 NolX protein; Region: NolX; pfam05819 266835013824 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 266835013825 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 266835013826 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 266835013827 Nodulation protein NolV; Region: NolV; pfam06635 266835013828 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 266835013829 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 266835013830 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 266835013831 Walker A motif/ATP binding site; other site 266835013832 Walker B motif; other site 266835013833 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 266835013834 FliP family; Region: FliP; cl00593 266835013835 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 266835013836 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 266835013837 Type III secretory pathway, component EscU [Intracellular trafficking and secretion]; Region: EscU; COG4792 266835013838 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 266835013839 Type IV pilus biogenesis; Region: Pilus_PilP; cl11837 266835013840 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 266835013841 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 266835013842 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266835013843 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835013844 binding surface 266835013845 TPR motif; other site 266835013846 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 266835013847 Integrase core domain; Region: rve; cl01316 266835013848 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 266835013849 Poxviridae protein; Region: Pox_E2-like; pfam04497 266835013850 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 266835013851 DDE superfamily endonuclease; Region: DDE_5; cl02413 266835013852 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 266835013853 Integrase core domain; Region: rve; cl01316 266835013854 Integrase core domain; Region: rve; cl01316 266835013855 hypothetical protein; Validated; Region: PRK09169 266835013856 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 266835013857 ADP binding site [chemical binding]; other site 266835013858 magnesium binding site [ion binding]; other site 266835013859 putative shikimate binding site; other site 266835013860 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 266835013861 Integrase core domain; Region: rve; cl01316 266835013862 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 266835013863 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 266835013864 Cytochrome P450; Region: p450; cl12078 266835013865 classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944 266835013866 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 266835013867 homodimer interface [polypeptide binding]; other site 266835013868 putative NAD(P) binding site [chemical binding]; other site 266835013869 active site 266835013870 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 266835013871 Cytochrome P450; Region: p450; pfam00067 266835013872 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 266835013873 substrate binding pocket [chemical binding]; other site 266835013874 chain length determination region; other site 266835013875 substrate-Mg2+ binding site; other site 266835013876 catalytic residues [active] 266835013877 aspartate-rich region 1; other site 266835013878 active site lid residues [active] 266835013879 aspartate-rich region 2; other site 266835013880 ent-copalyl diphosphate synthase; Region: PLN02592 266835013881 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 266835013882 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 266835013883 substrate binding pocket [chemical binding]; other site 266835013884 substrate-Mg2+ binding site; other site 266835013885 aspartate-rich region 1; other site 266835013886 aspartate-rich region 2; other site 266835013887 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 266835013888 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 266835013889 homotetramer interface [polypeptide binding]; other site 266835013890 FMN binding site [chemical binding]; other site 266835013891 homodimer contacts [polypeptide binding]; other site 266835013892 putative active site [active] 266835013893 putative substrate binding site [chemical binding]; other site 266835013894 Transmembrane secretion effector; Region: MFS_3; pfam05977 266835013895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835013896 putative substrate translocation pore; other site 266835013897 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266835013898 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266835013899 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 266835013900 inhibitor site; inhibition site 266835013901 active site 266835013902 dimer interface [polypeptide binding]; other site 266835013903 catalytic residue [active] 266835013904 LysE type translocator; Region: LysE; cl00565 266835013905 B3/4 domain; Region: B3_4; cl11458 266835013906 Integrase core domain; Region: rve; cl01316 266835013907 Integrase core domain; Region: rve; cl01316 266835013908 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 266835013909 Helix-turn-helix domains; Region: HTH; cl00088 266835013910 Helix-turn-helix domains; Region: HTH; cl00088 266835013911 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 266835013912 active site 266835013913 zinc binding site [ion binding]; other site 266835013914 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835013915 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 266835013916 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 266835013917 glutaminase active site [active] 266835013918 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 266835013919 dimer interface [polypeptide binding]; other site 266835013920 active site 266835013921 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 266835013922 dimer interface [polypeptide binding]; other site 266835013923 active site 266835013924 Porin subfamily; Region: Porin_2; pfam02530 266835013925 coproporphyrinogen III oxidase; Provisional; Region: PRK13347 266835013926 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835013927 FeS/SAM binding site; other site 266835013928 HemN C-terminal region; Region: HemN_C; pfam06969 266835013929 YodA lipocalin-like domain; Region: YodA; cl01365 266835013930 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 266835013931 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835013932 Walker A motif; other site 266835013933 ATP binding site [chemical binding]; other site 266835013934 Walker B motif; other site 266835013935 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 266835013936 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 266835013937 ATP binding site [chemical binding]; other site 266835013938 Walker A motif; other site 266835013939 hexamer interface [polypeptide binding]; other site 266835013940 Walker B motif; other site 266835013941 TrbC/VIRB2 family; Region: TrbC; cl01583 266835013942 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 266835013943 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 266835013944 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835013945 Walker A motif; other site 266835013946 ATP binding site [chemical binding]; other site 266835013947 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl14888 266835013948 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314; cl02193 266835013949 conjugal transfer protein TrbL; Provisional; Region: PRK13875 266835013950 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 266835013951 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 266835013952 VirB8 protein; Region: VirB8; cl01500 266835013953 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 266835013954 VirB7 interaction site; other site 266835013955 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 266835013956 Protein of unknown function (DUF2274); Region: DUF2274; cl02406 266835013957 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 266835013958 HemN C-terminal region; Region: HemN_C; pfam06969 266835013959 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266835013960 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266835013961 ligand binding site [chemical binding]; other site 266835013962 flexible hinge region; other site 266835013963 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266835013964 putative switch regulator; other site 266835013965 non-specific DNA interactions [nucleotide binding]; other site 266835013966 DNA binding site [nucleotide binding] 266835013967 sequence specific DNA binding site [nucleotide binding]; other site 266835013968 putative cAMP binding site [chemical binding]; other site 266835013969 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 266835013970 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 266835013971 Low-spin heme binding site [chemical binding]; other site 266835013972 Putative water exit pathway; other site 266835013973 Binuclear center (active site) [active] 266835013974 Putative proton exit pathway; other site 266835013975 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 266835013976 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 266835013977 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 266835013978 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 266835013979 Cytochrome c; Region: Cytochrom_C; cl11414 266835013980 Cytochrome c; Region: Cytochrom_C; cl11414 266835013981 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 266835013982 4Fe-4S binding domain; Region: Fer4_5; pfam12801 266835013983 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 266835013984 FixH; Region: FixH; cl01254 266835013985 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266835013986 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266835013987 metal-binding site [ion binding] 266835013988 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266835013989 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266835013990 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 266835013991 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266835013992 Fic family protein [Function unknown]; Region: COG3177 266835013993 Fic/DOC family; Region: Fic; cl00960 266835013994 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 266835013995 Ligand Binding Site [chemical binding]; other site 266835013996 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 266835013997 ATP binding site [chemical binding]; other site 266835013998 substrate binding site [chemical binding]; other site 266835013999 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl01450 266835014000 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 266835014001 helix-hairpin-helix signature motif; other site 266835014002 substrate binding pocket [chemical binding]; other site 266835014003 active site 266835014004 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266835014005 Zn2+ binding site [ion binding]; other site 266835014006 Mg2+ binding site [ion binding]; other site 266835014007 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 266835014008 Putative transposase; Region: Y2_Tnp; pfam04986 266835014009 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 266835014010 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 266835014011 Int/Topo IB signature motif; other site 266835014012 integrase; Provisional; Region: PRK09692 266835014013 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 266835014014 active site 266835014015 Int/Topo IB signature motif; other site 266835014016 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 266835014017 Cupin domain; Region: Cupin_2; cl09118 266835014018 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835014019 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835014020 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835014021 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 266835014022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835014023 dimer interface [polypeptide binding]; other site 266835014024 conserved gate region; other site 266835014025 putative PBP binding loops; other site 266835014026 ABC-ATPase subunit interface; other site 266835014027 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835014028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835014029 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266835014030 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 266835014031 Walker A/P-loop; other site 266835014032 ATP binding site [chemical binding]; other site 266835014033 Q-loop/lid; other site 266835014034 ABC transporter signature motif; other site 266835014035 Walker B; other site 266835014036 D-loop; other site 266835014037 H-loop/switch region; other site 266835014038 TOBE domain; Region: TOBE_2; cl01440 266835014039 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835014040 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835014041 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 266835014042 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835014043 active site 266835014044 catalytic tetrad [active] 266835014045 Cupin domain; Region: Cupin_2; cl09118 266835014046 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266835014047 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835014048 alpha-galactosidase; Provisional; Region: PRK15076 266835014049 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 266835014050 NAD binding site [chemical binding]; other site 266835014051 sugar binding site [chemical binding]; other site 266835014052 divalent metal binding site [ion binding]; other site 266835014053 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 266835014054 dimer interface [polypeptide binding]; other site 266835014055 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 266835014056 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835014057 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835014058 dimer interface [polypeptide binding]; other site 266835014059 conserved gate region; other site 266835014060 putative PBP binding loops; other site 266835014061 ABC-ATPase subunit interface; other site 266835014062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835014063 dimer interface [polypeptide binding]; other site 266835014064 conserved gate region; other site 266835014065 putative PBP binding loops; other site 266835014066 ABC-ATPase subunit interface; other site 266835014067 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 266835014068 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835014069 Walker A/P-loop; other site 266835014070 ATP binding site [chemical binding]; other site 266835014071 Q-loop/lid; other site 266835014072 ABC transporter signature motif; other site 266835014073 Walker B; other site 266835014074 D-loop; other site 266835014075 H-loop/switch region; other site 266835014076 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835014077 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835014078 Walker A/P-loop; other site 266835014079 ATP binding site [chemical binding]; other site 266835014080 Q-loop/lid; other site 266835014081 ABC transporter signature motif; other site 266835014082 Walker B; other site 266835014083 D-loop; other site 266835014084 H-loop/switch region; other site 266835014085 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835014086 alpha-galactosidase; Provisional; Region: PRK15076 266835014087 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 266835014088 NAD binding site [chemical binding]; other site 266835014089 sugar binding site [chemical binding]; other site 266835014090 divalent metal binding site [ion binding]; other site 266835014091 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 266835014092 dimer interface [polypeptide binding]; other site 266835014093 Domain of unknown function (DUF329); Region: DUF329; cl01144 266835014094 Maf-like protein; Region: Maf; pfam02545 266835014095 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 266835014096 active site 266835014097 dimer interface [polypeptide binding]; other site 266835014098 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 266835014099 rRNA binding site [nucleotide binding]; other site 266835014100 predicted 30S ribosome binding site; other site 266835014101 Low molecular weight phosphatase family; Region: LMWPc; cl00105 266835014102 active site 266835014103 Uncharacterised protein family (UPF0262); Region: UPF0262; cl11489 266835014104 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 266835014105 histidinol dehydrogenase; Region: hisD; TIGR00069 266835014106 NAD binding site [chemical binding]; other site 266835014107 dimerization interface [polypeptide binding]; other site 266835014108 product binding site; other site 266835014109 substrate binding site [chemical binding]; other site 266835014110 zinc binding site [ion binding]; other site 266835014111 catalytic residues [active] 266835014112 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 266835014113 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 266835014114 hinge; other site 266835014115 active site 266835014116 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 266835014117 cyclase homology domain; Region: CHD; cd07302 266835014118 nucleotidyl binding site; other site 266835014119 metal binding site [ion binding]; metal-binding site 266835014120 dimer interface [polypeptide binding]; other site 266835014121 Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486 266835014122 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 266835014123 Protein of unknown function (DUF1326); Region: DUF1326; cl02375 266835014124 Ribbon-helix-helix domain; Region: RHH_4; cl01775 266835014125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 266835014126 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 266835014127 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 266835014128 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 266835014129 TadE-like protein; Region: TadE; cl10688 266835014130 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 266835014131 TadE-like protein; Region: TadE; cl10688 266835014132 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 266835014133 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 266835014134 BON domain; Region: BON; cl02771 266835014135 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 266835014136 SAF domain; Region: SAF; cl00555 266835014137 Flp/Fap pilin component; Region: Flp_Fap; cl01585 266835014138 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 266835014139 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 266835014140 ATP binding site [chemical binding]; other site 266835014141 Walker A motif; other site 266835014142 hexamer interface [polypeptide binding]; other site 266835014143 Walker B motif; other site 266835014144 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 266835014145 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 266835014146 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 266835014147 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835014148 TPR motif; other site 266835014149 binding surface 266835014150 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 266835014151 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 266835014152 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 266835014153 Phospholipid methyltransferase; Region: PEMT; cl00763 266835014154 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 266835014155 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 266835014156 Peptidase M15; Region: Peptidase_M15_3; cl01194 266835014157 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 266835014158 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 266835014159 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 266835014160 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 266835014161 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835014162 SAF domain; Region: SAF; cl00555 266835014163 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 266835014164 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835014165 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 266835014166 O-Antigen ligase; Region: Wzy_C; cl04850 266835014167 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266835014168 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 266835014169 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 266835014170 MatE; Region: MatE; cl10513 266835014171 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 266835014172 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 266835014173 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 266835014174 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 266835014175 homodimer interface [polypeptide binding]; other site 266835014176 NADP binding site [chemical binding]; other site 266835014177 substrate binding site [chemical binding]; other site 266835014178 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266835014179 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 266835014180 conserved cys residue [active] 266835014181 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835014182 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 266835014183 metal ion-dependent adhesion site (MIDAS); other site 266835014184 Dehydratase family; Region: ILVD_EDD; cl00340 266835014185 6-phosphogluconate dehydratase; Region: edd; TIGR01196 266835014186 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 266835014187 putative active site [active] 266835014188 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 266835014189 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 266835014190 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 266835014191 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 266835014192 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266835014193 putative NAD(P) binding site [chemical binding]; other site 266835014194 active site 266835014195 Bacterial SH3 domain; Region: SH3_3; cl02551 266835014196 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835014197 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835014198 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 266835014199 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 266835014200 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266835014201 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 266835014202 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266835014203 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266835014204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835014205 active site 266835014206 phosphorylation site [posttranslational modification] 266835014207 intermolecular recognition site; other site 266835014208 dimerization interface [polypeptide binding]; other site 266835014209 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 266835014210 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266835014211 tetramer interface [polypeptide binding]; other site 266835014212 active site 266835014213 Mg2+/Mn2+ binding site [ion binding]; other site 266835014214 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835014215 non-specific DNA binding site [nucleotide binding]; other site 266835014216 salt bridge; other site 266835014217 sequence-specific DNA binding site [nucleotide binding]; other site 266835014218 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 266835014219 Domain of unknown function (DUF955); Region: DUF955; cl01076 266835014220 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 266835014221 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 266835014222 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835014223 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 266835014224 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 266835014225 Walker A/P-loop; other site 266835014226 ATP binding site [chemical binding]; other site 266835014227 Q-loop/lid; other site 266835014228 ABC transporter signature motif; other site 266835014229 Walker B; other site 266835014230 D-loop; other site 266835014231 H-loop/switch region; other site 266835014232 TOBE domain; Region: TOBE_2; cl01440 266835014233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835014234 dimer interface [polypeptide binding]; other site 266835014235 conserved gate region; other site 266835014236 putative PBP binding loops; other site 266835014237 ABC-ATPase subunit interface; other site 266835014238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835014239 dimer interface [polypeptide binding]; other site 266835014240 conserved gate region; other site 266835014241 putative PBP binding loops; other site 266835014242 ABC-ATPase subunit interface; other site 266835014243 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 266835014244 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 266835014245 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 266835014246 AMP-binding enzyme; Region: AMP-binding; cl15778 266835014247 AMP-binding enzyme; Region: AMP-binding; cl15778 266835014248 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266835014249 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 266835014250 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 266835014251 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835014252 dimer interface [polypeptide binding]; other site 266835014253 phosphorylation site [posttranslational modification] 266835014254 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835014255 ATP binding site [chemical binding]; other site 266835014256 Mg2+ binding site [ion binding]; other site 266835014257 G-X-G motif; other site 266835014258 Phasin protein; Region: Phasin_2; cl11491 266835014259 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266835014260 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835014261 DNA binding residues [nucleotide binding] 266835014262 dimerization interface [polypeptide binding]; other site 266835014263 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 266835014264 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835014265 Walker A motif; other site 266835014266 ATP binding site [chemical binding]; other site 266835014267 Walker B motif; other site 266835014268 arginine finger; other site 266835014269 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 266835014270 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 266835014271 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 266835014272 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 266835014273 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 266835014274 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 266835014275 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 266835014276 putative peptidoglycan binding site; other site 266835014277 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 266835014278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 266835014279 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 266835014280 Uncharacterized conserved protein [Function unknown]; Region: COG4104 266835014281 PAAR motif; Region: PAAR_motif; pfam05488 266835014282 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 266835014283 Baseplate J-like protein; Region: Baseplate_J; cl01294 266835014284 Baseplate J-like protein; Region: Baseplate_J; cl01294 266835014285 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 266835014286 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 266835014287 Uncharacterized conserved protein [Function unknown]; Region: COG5620 266835014288 GAD-like domain; Region: GAD-like; pfam08887 266835014289 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 266835014290 Cupin domain; Region: Cupin_2; cl09118 266835014291 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 266835014292 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 266835014293 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266835014294 Beta-Casp domain; Region: Beta-Casp; cl12567 266835014295 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 266835014296 putative phosphoketolase; Provisional; Region: PRK05261 266835014297 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 266835014298 TPP-binding site; other site 266835014299 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 266835014300 XFP C-terminal domain; Region: XFP_C; pfam09363 266835014301 Acetokinase family; Region: Acetate_kinase; cl01029 266835014302 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835014303 transcriptional regulator FixK; Provisional; Region: fixK; PRK09391 266835014304 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266835014305 ligand binding site [chemical binding]; other site 266835014306 flexible hinge region; other site 266835014307 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266835014308 putative switch regulator; other site 266835014309 non-specific DNA interactions [nucleotide binding]; other site 266835014310 DNA binding site [nucleotide binding] 266835014311 sequence specific DNA binding site [nucleotide binding]; other site 266835014312 putative cAMP binding site [chemical binding]; other site 266835014313 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 266835014314 active site 266835014315 metal binding site [ion binding]; metal-binding site 266835014316 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 266835014317 Catalytic domain of Protein Kinases; Region: PKc; cd00180 266835014318 active site 266835014319 ATP binding site [chemical binding]; other site 266835014320 substrate binding site [chemical binding]; other site 266835014321 activation loop (A-loop); other site 266835014322 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266835014323 Ligand Binding Site [chemical binding]; other site 266835014324 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 266835014325 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 266835014326 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 266835014327 Predicted membrane protein [Function unknown]; Region: COG3174 266835014328 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 266835014329 thioredoxin 2; Provisional; Region: PRK10996 266835014330 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 266835014331 catalytic residues [active] 266835014332 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266835014333 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266835014334 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266835014335 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 266835014336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835014337 CoA-ligase; Region: Ligase_CoA; cl02894 266835014338 ATP-grasp domain; Region: ATP-grasp_4; cl03087 266835014339 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266835014340 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835014341 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 266835014342 Predicted kinase [General function prediction only]; Region: COG0645 266835014343 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 266835014344 ATP-binding site [chemical binding]; other site 266835014345 Gluconate-6-phosphate binding site [chemical binding]; other site 266835014346 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266835014347 Ligand Binding Site [chemical binding]; other site 266835014348 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 266835014349 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266835014350 active site 266835014351 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 266835014352 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 266835014353 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 266835014354 substrate-cofactor binding pocket; other site 266835014355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835014356 catalytic residue [active] 266835014357 response regulator FixJ; Provisional; Region: fixJ; PRK09390 266835014358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835014359 active site 266835014360 phosphorylation site [posttranslational modification] 266835014361 intermolecular recognition site; other site 266835014362 dimerization interface [polypeptide binding]; other site 266835014363 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835014364 DNA binding residues [nucleotide binding] 266835014365 dimerization interface [polypeptide binding]; other site 266835014366 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 266835014367 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 266835014368 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835014369 putative active site [active] 266835014370 heme pocket [chemical binding]; other site 266835014371 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835014372 dimer interface [polypeptide binding]; other site 266835014373 phosphorylation site [posttranslational modification] 266835014374 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835014375 ATP binding site [chemical binding]; other site 266835014376 Mg2+ binding site [ion binding]; other site 266835014377 G-X-G motif; other site 266835014378 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 266835014379 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266835014380 Ligand Binding Site [chemical binding]; other site 266835014381 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 266835014382 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 266835014383 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266835014384 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 266835014385 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266835014386 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 266835014387 FOG: CBS domain [General function prediction only]; Region: COG0517 266835014388 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 266835014389 BON domain; Region: BON; cl02771 266835014390 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 266835014391 Peptidase propeptide and YPEB domain; Region: PepSY; cl15480 266835014392 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835014393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835014394 active site 266835014395 phosphorylation site [posttranslational modification] 266835014396 intermolecular recognition site; other site 266835014397 dimerization interface [polypeptide binding]; other site 266835014398 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835014399 DNA binding site [nucleotide binding] 266835014400 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266835014401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835014402 ATP binding site [chemical binding]; other site 266835014403 Mg2+ binding site [ion binding]; other site 266835014404 G-X-G motif; other site 266835014405 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 266835014406 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 266835014407 FAD binding pocket [chemical binding]; other site 266835014408 conserved FAD binding motif [chemical binding]; other site 266835014409 phosphate binding motif [ion binding]; other site 266835014410 beta-alpha-beta structure motif; other site 266835014411 NAD binding pocket [chemical binding]; other site 266835014412 ApbE family; Region: ApbE; cl00643 266835014413 FMN-binding domain; Region: FMN_bind; cl01081 266835014414 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 266835014415 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 266835014416 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266835014417 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266835014418 metal-binding site [ion binding] 266835014419 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266835014420 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266835014421 FixH; Region: FixH; cl01254 266835014422 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 266835014423 4Fe-4S binding domain; Region: Fer4_5; pfam12801 266835014424 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 266835014425 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 266835014426 Cytochrome c; Region: Cytochrom_C; cl11414 266835014427 Cytochrome c; Region: Cytochrom_C; cl11414 266835014428 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 266835014429 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 266835014430 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 266835014431 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 266835014432 Low-spin heme binding site [chemical binding]; other site 266835014433 Putative water exit pathway; other site 266835014434 Binuclear center (active site) [active] 266835014435 Putative proton exit pathway; other site 266835014436 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 266835014437 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266835014438 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266835014439 ligand binding site [chemical binding]; other site 266835014440 flexible hinge region; other site 266835014441 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266835014442 putative switch regulator; other site 266835014443 non-specific DNA interactions [nucleotide binding]; other site 266835014444 DNA binding site [nucleotide binding] 266835014445 sequence specific DNA binding site [nucleotide binding]; other site 266835014446 putative cAMP binding site [chemical binding]; other site 266835014447 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 266835014448 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835014449 FeS/SAM binding site; other site 266835014450 HemN C-terminal region; Region: HemN_C; pfam06969 266835014451 voltage-gated potassium channel; Provisional; Region: PRK10537 266835014452 Ion channel; Region: Ion_trans_2; cl11596 266835014453 Protein of unknown function (DUF779); Region: DUF779; cl01432 266835014454 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 266835014455 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835014456 NAD(P) binding site [chemical binding]; other site 266835014457 catalytic residues [active] 266835014458 GAF domain; Region: GAF; cl15785 266835014459 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 266835014460 Helix-turn-helix domains; Region: HTH; cl00088 266835014461 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 266835014462 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 266835014463 active site 266835014464 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266835014465 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835014466 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835014467 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 266835014468 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 266835014469 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266835014470 PYR/PP interface [polypeptide binding]; other site 266835014471 dimer interface [polypeptide binding]; other site 266835014472 TPP binding site [chemical binding]; other site 266835014473 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 266835014474 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 266835014475 TPP-binding site [chemical binding]; other site 266835014476 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 266835014477 histidinol dehydrogenase; Region: hisD; TIGR00069 266835014478 NAD binding site [chemical binding]; other site 266835014479 dimerization interface [polypeptide binding]; other site 266835014480 product binding site; other site 266835014481 substrate binding site [chemical binding]; other site 266835014482 zinc binding site [ion binding]; other site 266835014483 catalytic residues [active] 266835014484 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835014485 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835014486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835014487 dimer interface [polypeptide binding]; other site 266835014488 putative PBP binding loops; other site 266835014489 ABC-ATPase subunit interface; other site 266835014490 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835014491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835014492 dimer interface [polypeptide binding]; other site 266835014493 conserved gate region; other site 266835014494 putative PBP binding loops; other site 266835014495 ABC-ATPase subunit interface; other site 266835014496 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266835014497 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 266835014498 Walker A/P-loop; other site 266835014499 ATP binding site [chemical binding]; other site 266835014500 Q-loop/lid; other site 266835014501 ABC transporter signature motif; other site 266835014502 Walker B; other site 266835014503 D-loop; other site 266835014504 H-loop/switch region; other site 266835014505 TOBE domain; Region: TOBE_2; cl01440 266835014506 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 266835014507 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266835014508 choline dehydrogenase; Validated; Region: PRK02106 266835014509 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266835014510 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835014511 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835014512 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835014513 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 266835014514 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_3; cd08770 266835014515 SxDxEG motif; other site 266835014516 putative active site [active] 266835014517 putative metal binding site [ion binding]; other site 266835014518 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266835014519 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835014520 catalytic residue [active] 266835014521 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266835014522 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 266835014523 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 266835014524 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 266835014525 dimer interface [polypeptide binding]; other site 266835014526 active site 266835014527 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266835014528 substrate binding site [chemical binding]; other site 266835014529 catalytic residue [active] 266835014530 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835014531 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835014532 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835014533 non-specific DNA binding site [nucleotide binding]; other site 266835014534 salt bridge; other site 266835014535 sequence-specific DNA binding site [nucleotide binding]; other site 266835014536 Cupin domain; Region: Cupin_2; cl09118 266835014537 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 266835014538 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 266835014539 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835014540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835014541 dimer interface [polypeptide binding]; other site 266835014542 conserved gate region; other site 266835014543 putative PBP binding loops; other site 266835014544 ABC-ATPase subunit interface; other site 266835014545 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 266835014546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835014547 dimer interface [polypeptide binding]; other site 266835014548 conserved gate region; other site 266835014549 putative PBP binding loops; other site 266835014550 ABC-ATPase subunit interface; other site 266835014551 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266835014552 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835014553 Walker A/P-loop; other site 266835014554 ATP binding site [chemical binding]; other site 266835014555 Q-loop/lid; other site 266835014556 ABC transporter signature motif; other site 266835014557 Walker B; other site 266835014558 D-loop; other site 266835014559 H-loop/switch region; other site 266835014560 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835014561 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 266835014562 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835014563 Walker A/P-loop; other site 266835014564 ATP binding site [chemical binding]; other site 266835014565 Q-loop/lid; other site 266835014566 ABC transporter signature motif; other site 266835014567 Walker B; other site 266835014568 D-loop; other site 266835014569 H-loop/switch region; other site 266835014570 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835014571 Uncharacterized conserved protein [Function unknown]; Region: COG5476 266835014572 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 266835014573 MlrC C-terminus; Region: MlrC_C; pfam07171 266835014574 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835014575 DNA binding site [nucleotide binding] 266835014576 OsmC-like protein; Region: OsmC; cl00767 266835014577 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835014578 DNA binding site [nucleotide binding] 266835014579 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835014580 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835014581 Epoxide hydrolase N terminus; Region: EHN; pfam06441 266835014582 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 266835014583 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266835014584 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835014585 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835014586 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 266835014587 putative active site [active] 266835014588 putative catalytic site [active] 266835014589 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 266835014590 classical (c) SDRs; Region: SDR_c; cd05233 266835014591 NAD(P) binding site [chemical binding]; other site 266835014592 active site 266835014593 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835014594 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 266835014595 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 266835014596 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835014597 putative active site [active] 266835014598 heme pocket [chemical binding]; other site 266835014599 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835014600 dimer interface [polypeptide binding]; other site 266835014601 phosphorylation site [posttranslational modification] 266835014602 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835014603 ATP binding site [chemical binding]; other site 266835014604 Mg2+ binding site [ion binding]; other site 266835014605 G-X-G motif; other site 266835014606 Response regulator receiver domain; Region: Response_reg; pfam00072 266835014607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835014608 active site 266835014609 phosphorylation site [posttranslational modification] 266835014610 intermolecular recognition site; other site 266835014611 dimerization interface [polypeptide binding]; other site 266835014612 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835014613 active site 266835014614 phosphorylation site [posttranslational modification] 266835014615 intermolecular recognition site; other site 266835014616 Response regulator receiver domain; Region: Response_reg; pfam00072 266835014617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835014618 active site 266835014619 phosphorylation site [posttranslational modification] 266835014620 intermolecular recognition site; other site 266835014621 dimerization interface [polypeptide binding]; other site 266835014622 Response regulator receiver domain; Region: Response_reg; pfam00072 266835014623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835014624 active site 266835014625 phosphorylation site [posttranslational modification] 266835014626 intermolecular recognition site; other site 266835014627 dimerization interface [polypeptide binding]; other site 266835014628 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835014629 binding surface 266835014630 TPR motif; other site 266835014631 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835014632 binding surface 266835014633 TPR motif; other site 266835014634 tetratricopeptide repeat protein; Provisional; Region: PRK11788 266835014635 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488 266835014636 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 266835014637 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266835014638 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 266835014639 DXD motif; other site 266835014640 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 266835014641 putative binding surface; other site 266835014642 active site 266835014643 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 266835014644 active site 266835014645 DNA binding site [nucleotide binding] 266835014646 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 266835014647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 266835014648 Cache domain; Region: Cache_1; pfam02743 266835014649 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 266835014650 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266835014651 dimerization interface [polypeptide binding]; other site 266835014652 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 266835014653 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 266835014654 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 266835014655 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835014656 S-adenosylmethionine binding site [chemical binding]; other site 266835014657 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 266835014658 Transposase domain (DUF772); Region: DUF772; cl15789 266835014659 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835014660 metal binding site [ion binding]; metal-binding site 266835014661 active site 266835014662 I-site; other site 266835014663 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835014664 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 266835014665 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266835014666 classical (c) SDRs; Region: SDR_c; cd05233 266835014667 NAD(P) binding site [chemical binding]; other site 266835014668 active site 266835014669 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 266835014670 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835014671 inhibitor-cofactor binding pocket; inhibition site 266835014672 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835014673 catalytic residue [active] 266835014674 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 266835014675 active site 266835014676 substrate binding site [chemical binding]; other site 266835014677 Phosphotransferase enzyme family; Region: APH; pfam01636 266835014678 ATP binding site [chemical binding]; other site 266835014679 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 266835014680 classical (c) SDRs; Region: SDR_c; cd05233 266835014681 NAD(P) binding site [chemical binding]; other site 266835014682 active site 266835014683 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 266835014684 Spore germination protein; Region: Spore_permease; cl15802 266835014685 Isochorismatase family; Region: Isochorismatase; pfam00857 266835014686 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 266835014687 catalytic triad [active] 266835014688 conserved cis-peptide bond; other site 266835014689 Dehydratase small subunit; Region: Dehydratase_SU; cl02055 266835014690 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 266835014691 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 266835014692 alpha-beta subunit interface [polypeptide binding]; other site 266835014693 alpha-gamma subunit interface [polypeptide binding]; other site 266835014694 active site 266835014695 substrate and K+ binding site; other site 266835014696 K+ binding site [ion binding]; other site 266835014697 cobalamin binding site [chemical binding]; other site 266835014698 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 266835014699 Predicted membrane protein [Function unknown]; Region: COG4425 266835014700 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 266835014701 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 266835014702 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266835014703 Domain of unknown function DUF20; Region: UPF0118; cl00465 266835014704 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 266835014705 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835014706 Uncharacterized conserved protein [Function unknown]; Region: HdeD; cl01277 266835014707 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 266835014708 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266835014709 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 266835014710 Amidinotransferase; Region: Amidinotransf; cl12043 266835014711 arginine/ornithine antiporter; Region: arg_ornith_anti; TIGR03810 266835014712 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 266835014713 Amino acid permease; Region: AA_permease; cl00524 266835014714 Cupin domain; Region: Cupin_2; cl09118 266835014715 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 266835014716 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835014717 active site 266835014718 catalytic tetrad [active] 266835014719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835014720 S-adenosylmethionine binding site [chemical binding]; other site 266835014721 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 266835014722 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 266835014723 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 266835014724 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 266835014725 dimer interface [polypeptide binding]; other site 266835014726 active site 266835014727 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 266835014728 Ligand Binding Site [chemical binding]; other site 266835014729 Molecular Tunnel; other site 266835014730 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 266835014731 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 266835014732 homodimer interface [polypeptide binding]; other site 266835014733 NAD binding pocket [chemical binding]; other site 266835014734 ATP binding pocket [chemical binding]; other site 266835014735 Mg binding site [ion binding]; other site 266835014736 active-site loop [active] 266835014737 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266835014738 AMP-binding enzyme; Region: AMP-binding; cl15778 266835014739 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 266835014740 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 266835014741 TMP-binding site; other site 266835014742 ATP-binding site [chemical binding]; other site 266835014743 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 266835014744 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 266835014745 AMP-binding enzyme; Region: AMP-binding; pfam00501 266835014746 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 266835014747 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 266835014748 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266835014749 putative ADP-binding pocket [chemical binding]; other site 266835014750 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 266835014751 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 266835014752 active site 266835014753 dimer interface [polypeptide binding]; other site 266835014754 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 266835014755 Ligand Binding Site [chemical binding]; other site 266835014756 Molecular Tunnel; other site 266835014757 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 266835014758 Chain length determinant protein; Region: Wzz; cl01623 266835014759 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 266835014760 MatE; Region: MatE; cl10513 266835014761 OpgC protein; Region: OpgC_C; cl00792 266835014762 Acyltransferase family; Region: Acyl_transf_3; pfam01757 266835014763 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835014764 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 266835014765 putative NAD(P) binding site [chemical binding]; other site 266835014766 active site 266835014767 putative substrate binding site [chemical binding]; other site 266835014768 Helix-turn-helix domains; Region: HTH; cl00088 266835014769 putative diguanylate cyclase; Provisional; Region: PRK09776 266835014770 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835014771 putative active site [active] 266835014772 heme pocket [chemical binding]; other site 266835014773 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266835014774 Histidine kinase; Region: HisKA_2; cl06527 266835014775 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266835014776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835014777 active site 266835014778 phosphorylation site [posttranslational modification] 266835014779 intermolecular recognition site; other site 266835014780 dimerization interface [polypeptide binding]; other site 266835014781 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835014782 DNA binding residues [nucleotide binding] 266835014783 dimerization interface [polypeptide binding]; other site 266835014784 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266835014785 active site 266835014786 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 266835014787 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 266835014788 inhibitor-cofactor binding pocket; inhibition site 266835014789 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835014790 catalytic residue [active] 266835014791 Bacterial sugar transferase; Region: Bac_transf; cl00939 266835014792 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 266835014793 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 266835014794 NAD binding site [chemical binding]; other site 266835014795 substrate binding site [chemical binding]; other site 266835014796 active site 266835014797 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 266835014798 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 266835014799 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 266835014800 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 266835014801 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835014802 S-adenosylmethionine binding site [chemical binding]; other site 266835014803 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 266835014804 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 266835014805 This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export...; Region: ABCC_Protease_Secretion; cd03246 266835014806 Walker A/P-loop; other site 266835014807 ATP binding site [chemical binding]; other site 266835014808 Q-loop/lid; other site 266835014809 ABC transporter signature motif; other site 266835014810 Walker B; other site 266835014811 D-loop; other site 266835014812 H-loop/switch region; other site 266835014813 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 266835014814 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 266835014815 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 266835014816 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 266835014817 glutaminase active site [active] 266835014818 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 266835014819 dimer interface [polypeptide binding]; other site 266835014820 active site 266835014821 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 266835014822 dimer interface [polypeptide binding]; other site 266835014823 active site 266835014824 ornithine cyclodeaminase; Validated; Region: PRK07589 266835014825 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835014826 Arginase family; Region: Arginase; cl00306 266835014827 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835014828 Helix-turn-helix domains; Region: HTH; cl00088 266835014829 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835014830 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835014831 DNA-binding site [nucleotide binding]; DNA binding site 266835014832 FCD domain; Region: FCD; cl11656 266835014833 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835014834 Helix-turn-helix domains; Region: HTH; cl00088 266835014835 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835014836 dimerization interface [polypeptide binding]; other site 266835014837 Membrane transport protein; Region: Mem_trans; cl09117 266835014838 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 266835014839 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266835014840 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835014841 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835014842 DNA-binding site [nucleotide binding]; DNA binding site 266835014843 FCD domain; Region: FCD; cl11656 266835014844 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835014845 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835014846 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 266835014847 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835014848 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835014849 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835014850 Amino acid synthesis; Region: AA_synth; pfam06684 266835014851 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 266835014852 substrate binding site [chemical binding]; other site 266835014853 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 266835014854 intersubunit interface [polypeptide binding]; other site 266835014855 active site 266835014856 Zn2+ binding site [ion binding]; other site 266835014857 choline dehydrogenase; Validated; Region: PRK02106 266835014858 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835014859 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266835014860 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK06130 266835014861 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835014862 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266835014863 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266835014864 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 266835014865 Walker A/P-loop; other site 266835014866 ATP binding site [chemical binding]; other site 266835014867 Q-loop/lid; other site 266835014868 ABC transporter signature motif; other site 266835014869 Walker B; other site 266835014870 D-loop; other site 266835014871 H-loop/switch region; other site 266835014872 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266835014873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835014874 dimer interface [polypeptide binding]; other site 266835014875 conserved gate region; other site 266835014876 ABC-ATPase subunit interface; other site 266835014877 NMT1-like family; Region: NMT1_2; cl15260 266835014878 NMT1/THI5 like; Region: NMT1; pfam09084 266835014879 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 266835014880 putative ligand binding site [chemical binding]; other site 266835014881 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 266835014882 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 266835014883 Walker A/P-loop; other site 266835014884 ATP binding site [chemical binding]; other site 266835014885 Q-loop/lid; other site 266835014886 ABC transporter signature motif; other site 266835014887 Walker B; other site 266835014888 D-loop; other site 266835014889 H-loop/switch region; other site 266835014890 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 266835014891 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266835014892 TM-ABC transporter signature motif; other site 266835014893 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266835014894 TM-ABC transporter signature motif; other site 266835014895 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266835014896 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 266835014897 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266835014898 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835014899 catalytic residue [active] 266835014900 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266835014901 classical (c) SDRs; Region: SDR_c; cd05233 266835014902 NAD(P) binding site [chemical binding]; other site 266835014903 active site 266835014904 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266835014905 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 266835014906 inhibitor site; inhibition site 266835014907 active site 266835014908 dimer interface [polypeptide binding]; other site 266835014909 catalytic residue [active] 266835014910 Proline racemase; Region: Pro_racemase; pfam05544 266835014911 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 266835014912 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 266835014913 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 266835014914 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 266835014915 Type IV pilus biogenesis; Region: Pilus_PilP; cl11837 266835014916 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 266835014917 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 266835014918 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 266835014919 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 266835014920 Walker A motif; other site 266835014921 ATP binding site [chemical binding]; other site 266835014922 Walker B motif; other site 266835014923 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 266835014924 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 266835014925 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 266835014926 general secretion pathway protein H; Region: typeII_sec_gspH; TIGR01708 266835014927 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 266835014928 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 266835014929 Bacterial type II secretion system protein G; Region: GSPII_G; pfam08334 266835014930 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 266835014931 general secretion pathway protein D; Region: type_II_gspD; TIGR02517 266835014932 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 266835014933 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 266835014934 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 266835014935 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 266835014936 Transposase IS200 like; Region: Y1_Tnp; cl00848 266835014937 Transposase IS200 like; Region: Y1_Tnp; cl00848 266835014938 Transposase IS200 like; Region: Y1_Tnp; cl00848 266835014939 Transposase IS200 like; Region: Y1_Tnp; cl00848 266835014940 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 266835014941 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 266835014942 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 266835014943 RHS Repeat; Region: RHS_repeat; cl11982 266835014944 RHS Repeat; Region: RHS_repeat; cl11982 266835014945 RHS Repeat; Region: RHS_repeat; cl11982 266835014946 RHS Repeat; Region: RHS_repeat; cl11982 266835014947 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 266835014948 Helix-turn-helix domains; Region: HTH; cl00088 266835014949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835014950 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835014951 putative substrate translocation pore; other site 266835014952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835014953 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 266835014954 Prostaglandin dehydrogenases; Region: PGDH; cd05288 266835014955 NAD(P) binding site [chemical binding]; other site 266835014956 substrate binding site [chemical binding]; other site 266835014957 dimer interface [polypeptide binding]; other site 266835014958 metabolite-proton symporter; Region: 2A0106; TIGR00883 266835014959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835014960 putative substrate translocation pore; other site 266835014961 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 266835014962 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 266835014963 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 266835014964 D-pathway; other site 266835014965 Putative ubiquinol binding site [chemical binding]; other site 266835014966 Low-spin heme (heme b) binding site [chemical binding]; other site 266835014967 Putative water exit pathway; other site 266835014968 Binuclear center (heme o3/CuB) [ion binding]; other site 266835014969 K-pathway; other site 266835014970 Putative proton exit pathway; other site 266835014971 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 266835014972 Subunit I/III interface [polypeptide binding]; other site 266835014973 Subunit III/IV interface [polypeptide binding]; other site 266835014974 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 266835014975 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 266835014976 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835014977 dimer interface [polypeptide binding]; other site 266835014978 phosphorylation site [posttranslational modification] 266835014979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835014980 ATP binding site [chemical binding]; other site 266835014981 Mg2+ binding site [ion binding]; other site 266835014982 G-X-G motif; other site 266835014983 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 266835014984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835014985 active site 266835014986 phosphorylation site [posttranslational modification] 266835014987 intermolecular recognition site; other site 266835014988 dimerization interface [polypeptide binding]; other site 266835014989 Helix-turn-helix domains; Region: HTH; cl00088 266835014990 Isochorismatase family; Region: Isochorismatase; pfam00857 266835014991 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 266835014992 catalytic triad [active] 266835014993 conserved cis-peptide bond; other site 266835014994 Protein of unknown function (DUF763); Region: DUF763; cl00620 266835014995 Domain of unknown function (DUF296); Region: DUF296; cl00720 266835014996 short chain dehydrogenase; Provisional; Region: PRK06701 266835014997 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835014998 NAD(P) binding site [chemical binding]; other site 266835014999 active site 266835015000 KTSC domain; Region: KTSC; pfam13619 266835015001 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 266835015002 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 266835015003 classical (c) SDRs; Region: SDR_c; cd05233 266835015004 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK12481 266835015005 NAD(P) binding site [chemical binding]; other site 266835015006 active site 266835015007 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266835015008 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835015009 DNA-binding site [nucleotide binding]; DNA binding site 266835015010 FCD domain; Region: FCD; cl11656 266835015011 mannonate dehydratase; Provisional; Region: PRK03906 266835015012 mannonate dehydratase; Region: uxuA; TIGR00695 266835015013 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 266835015014 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835015015 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 266835015016 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835015017 trimer interface [polypeptide binding]; other site 266835015018 oxyanion hole (OAH) forming residues; other site 266835015019 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266835015020 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835015021 US22 family homolog; Provisional; Region: PHA03342 266835015022 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835015023 DNA binding site [nucleotide binding] 266835015024 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835015025 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 266835015026 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266835015027 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266835015028 FAD binding domain; Region: FAD_binding_4; pfam01565 266835015029 Berberine and berberine like; Region: BBE; pfam08031 266835015030 N-formylglutamate amidohydrolase; Region: FGase; cl01522 266835015031 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835015032 DNA binding residues [nucleotide binding] 266835015033 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 266835015034 active site 266835015035 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 266835015036 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; cl14733 266835015037 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 266835015038 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835015039 NAD(P) binding site [chemical binding]; other site 266835015040 active site 266835015041 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 266835015042 homodimer interface [polypeptide binding]; other site 266835015043 homotetramer interface [polypeptide binding]; other site 266835015044 active site pocket [active] 266835015045 cleavage site 266835015046 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 266835015047 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 266835015048 generic binding surface II; other site 266835015049 generic binding surface I; other site 266835015050 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835015051 Helix-turn-helix domains; Region: HTH; cl00088 266835015052 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835015053 dimerization interface [polypeptide binding]; other site 266835015054 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 266835015055 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 266835015056 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 266835015057 RNA methyltransferase, RsmE family; Region: TIGR00046 266835015058 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 266835015059 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 266835015060 catalytic triad [active] 266835015061 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266835015062 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 266835015063 active site 266835015064 metal binding site [ion binding]; metal-binding site 266835015065 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 266835015066 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 266835015067 phosphate binding site [ion binding]; other site 266835015068 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 266835015069 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835015070 DNA-binding site [nucleotide binding]; DNA binding site 266835015071 FCD domain; Region: FCD; cl11656 266835015072 Protein of unknown function (DUF3422); Region: DUF3422; cl02073 266835015073 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 266835015074 FAD binding domain; Region: FAD_binding_4; pfam01565 266835015075 manganese transport regulator MntR; Provisional; Region: PRK11050 266835015076 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 266835015077 FAD binding domain; Region: FAD_binding_4; pfam01565 266835015078 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 266835015079 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 266835015080 Cysteine-rich domain; Region: CCG; pfam02754 266835015081 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 266835015082 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 266835015083 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 266835015084 homodimer interface [polypeptide binding]; other site 266835015085 NADP binding site [chemical binding]; other site 266835015086 substrate binding site [chemical binding]; other site 266835015087 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 266835015088 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 266835015089 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 266835015090 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 266835015091 dimer interface [polypeptide binding]; other site 266835015092 motif 1; other site 266835015093 motif 2; other site 266835015094 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 266835015095 active site 266835015096 motif 3; other site 266835015097 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 266835015098 anticodon binding site; other site 266835015099 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 266835015100 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 266835015101 dimer interface [polypeptide binding]; other site 266835015102 motif 1; other site 266835015103 motif 2; other site 266835015104 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 266835015105 active site 266835015106 motif 3; other site 266835015107 ATP phosphoribosyltransferase; Region: HisG; cl15266 266835015108 AMP-binding domain protein; Validated; Region: PRK08315 266835015109 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 266835015110 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 266835015111 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 266835015112 AMP-binding domain protein; Validated; Region: PRK08315 266835015113 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835015114 Helix-turn-helix domains; Region: HTH; cl00088 266835015115 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 266835015116 putative effector binding pocket; other site 266835015117 putative dimerization interface [polypeptide binding]; other site 266835015118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835015119 S-adenosylmethionine binding site [chemical binding]; other site 266835015120 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 266835015121 Helix-turn-helix domains; Region: HTH; cl00088 266835015122 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 266835015123 dimerization interface [polypeptide binding]; other site 266835015124 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 266835015125 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 266835015126 dimer interface [polypeptide binding]; other site 266835015127 active site 266835015128 heme binding site [chemical binding]; other site 266835015129 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 266835015130 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 266835015131 amphipathic channel; other site 266835015132 Asn-Pro-Ala signature motifs; other site 266835015133 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 266835015134 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 266835015135 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266835015136 CoenzymeA binding site [chemical binding]; other site 266835015137 subunit interaction site [polypeptide binding]; other site 266835015138 PHB binding site; other site 266835015139 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 266835015140 Helix-turn-helix domains; Region: HTH; cl00088 266835015141 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266835015142 GMP synthase; Reviewed; Region: guaA; PRK00074 266835015143 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 266835015144 AMP/PPi binding site [chemical binding]; other site 266835015145 candidate oxyanion hole; other site 266835015146 catalytic triad [active] 266835015147 potential glutamine specificity residues [chemical binding]; other site 266835015148 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 266835015149 ATP Binding subdomain [chemical binding]; other site 266835015150 Ligand Binding sites [chemical binding]; other site 266835015151 Dimerization subdomain; other site 266835015152 integrase; Provisional; Region: PRK09692 266835015153 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 266835015154 active site 266835015155 Int/Topo IB signature motif; other site 266835015156 HipA N-terminal domain; Region: Couple_hipA; cl11853 266835015157 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 266835015158 HipA-like N-terminal domain; Region: HipA_N; pfam07805 266835015159 HipA-like C-terminal domain; Region: HipA_C; pfam07804 266835015160 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835015161 non-specific DNA binding site [nucleotide binding]; other site 266835015162 salt bridge; other site 266835015163 sequence-specific DNA binding site [nucleotide binding]; other site 266835015164 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 266835015165 Protein of unknown function (DUF2274); Region: DUF2274; cl02406 266835015166 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835015167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835015168 NAD(P) binding site [chemical binding]; other site 266835015169 active site 266835015170 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835015171 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 266835015172 Transposase domain (DUF772); Region: DUF772; cl15789 266835015173 hypothetical protein; Provisional; Region: PRK07036 266835015174 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835015175 inhibitor-cofactor binding pocket; inhibition site 266835015176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835015177 catalytic residue [active] 266835015178 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835015179 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835015180 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 266835015181 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835015182 Walker A/P-loop; other site 266835015183 ATP binding site [chemical binding]; other site 266835015184 Q-loop/lid; other site 266835015185 ABC transporter signature motif; other site 266835015186 Walker B; other site 266835015187 D-loop; other site 266835015188 H-loop/switch region; other site 266835015189 TOBE domain; Region: TOBE_2; cl01440 266835015190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835015191 dimer interface [polypeptide binding]; other site 266835015192 conserved gate region; other site 266835015193 putative PBP binding loops; other site 266835015194 ABC-ATPase subunit interface; other site 266835015195 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835015196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835015197 dimer interface [polypeptide binding]; other site 266835015198 conserved gate region; other site 266835015199 putative PBP binding loops; other site 266835015200 ABC-ATPase subunit interface; other site 266835015201 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 266835015202 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 266835015203 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 266835015204 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835015205 NAD binding site [chemical binding]; other site 266835015206 catalytic residues [active] 266835015207 transcriptional regulator EutR; Provisional; Region: PRK10130 266835015208 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835015209 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266835015210 Helix-turn-helix domains; Region: HTH; cl00088 266835015211 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266835015212 dimerization interface [polypeptide binding]; other site 266835015213 substrate binding pocket [chemical binding]; other site 266835015214 putative dimethyl sulfoniopropionate demethylase; Reviewed; Region: dmdA; PRK12486 266835015215 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835015216 acyl-CoA synthetase; Validated; Region: PRK08162 266835015217 AMP-binding enzyme; Region: AMP-binding; cl15778 266835015218 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266835015219 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266835015220 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266835015221 active site 266835015222 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 266835015223 enoyl-CoA hydratase; Provisional; Region: PRK08150 266835015224 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835015225 substrate binding site [chemical binding]; other site 266835015226 oxyanion hole (OAH) forming residues; other site 266835015227 trimer interface [polypeptide binding]; other site 266835015228 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266835015229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835015230 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266835015231 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 266835015232 Walker A/P-loop; other site 266835015233 ATP binding site [chemical binding]; other site 266835015234 Q-loop/lid; other site 266835015235 ABC transporter signature motif; other site 266835015236 Walker B; other site 266835015237 D-loop; other site 266835015238 H-loop/switch region; other site 266835015239 NMT1-like family; Region: NMT1_2; cl15260 266835015240 NMT1/THI5 like; Region: NMT1; pfam09084 266835015241 PrpF protein; Region: PrpF; pfam04303 266835015242 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 266835015243 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835015244 Helix-turn-helix domains; Region: HTH; cl00088 266835015245 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 266835015246 putative dimerization interface [polypeptide binding]; other site 266835015247 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 266835015248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835015249 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 266835015250 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266835015251 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 266835015252 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 266835015253 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 266835015254 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266835015255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835015256 dimer interface [polypeptide binding]; other site 266835015257 conserved gate region; other site 266835015258 putative PBP binding loops; other site 266835015259 ABC-ATPase subunit interface; other site 266835015260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835015261 dimer interface [polypeptide binding]; other site 266835015262 conserved gate region; other site 266835015263 putative PBP binding loops; other site 266835015264 ABC-ATPase subunit interface; other site 266835015265 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 266835015266 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835015267 substrate binding pocket [chemical binding]; other site 266835015268 membrane-bound complex binding site; other site 266835015269 hinge residues; other site 266835015270 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835015271 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835015272 DNA-binding site [nucleotide binding]; DNA binding site 266835015273 FCD domain; Region: FCD; cl11656 266835015274 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835015275 Helix-turn-helix domains; Region: HTH; cl00088 266835015276 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266835015277 dimerization interface [polypeptide binding]; other site 266835015278 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 266835015279 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835015280 inhibitor-cofactor binding pocket; inhibition site 266835015281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835015282 catalytic residue [active] 266835015283 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835015284 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835015285 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 266835015286 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835015287 Protein of unknown function (DUF982); Region: DUF982; pfam06169 266835015288 Protein of unknown function (DUF982); Region: DUF982; pfam06169 266835015289 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 266835015290 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835015291 sequence-specific DNA binding site [nucleotide binding]; other site 266835015292 salt bridge; other site 266835015293 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835015294 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 266835015295 Predicted acyl esterases [General function prediction only]; Region: COG2936 266835015296 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835015297 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 266835015298 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835015299 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835015300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835015301 dimer interface [polypeptide binding]; other site 266835015302 conserved gate region; other site 266835015303 putative PBP binding loops; other site 266835015304 ABC-ATPase subunit interface; other site 266835015305 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835015306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835015307 dimer interface [polypeptide binding]; other site 266835015308 conserved gate region; other site 266835015309 putative PBP binding loops; other site 266835015310 ABC-ATPase subunit interface; other site 266835015311 Putative endoglucanase; Region: Glyco_hydro_101; pfam12905 266835015312 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266835015313 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 266835015314 Walker A/P-loop; other site 266835015315 ATP binding site [chemical binding]; other site 266835015316 Q-loop/lid; other site 266835015317 ABC transporter signature motif; other site 266835015318 Walker B; other site 266835015319 D-loop; other site 266835015320 H-loop/switch region; other site 266835015321 TOBE domain; Region: TOBE_2; cl01440 266835015322 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 266835015323 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 266835015324 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 266835015325 dimer interface [polypeptide binding]; other site 266835015326 active site 266835015327 catalytic residue [active] 266835015328 metal binding site [ion binding]; metal-binding site 266835015329 transcriptional regulator NanR; Provisional; Region: PRK03837 266835015330 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835015331 DNA-binding site [nucleotide binding]; DNA binding site 266835015332 FCD domain; Region: FCD; cl11656 266835015333 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835015334 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835015335 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 266835015336 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835015337 TM-ABC transporter signature motif; other site 266835015338 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835015339 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 266835015340 Walker A/P-loop; other site 266835015341 ATP binding site [chemical binding]; other site 266835015342 Q-loop/lid; other site 266835015343 ABC transporter signature motif; other site 266835015344 Walker B; other site 266835015345 D-loop; other site 266835015346 H-loop/switch region; other site 266835015347 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 266835015348 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; cl02395 266835015349 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 266835015350 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266835015351 ligand binding site [chemical binding]; other site 266835015352 dimerization interface [polypeptide binding]; other site 266835015353 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835015354 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835015355 TM-ABC transporter signature motif; other site 266835015356 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835015357 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 266835015358 Walker A/P-loop; other site 266835015359 ATP binding site [chemical binding]; other site 266835015360 Q-loop/lid; other site 266835015361 ABC transporter signature motif; other site 266835015362 Walker B; other site 266835015363 D-loop; other site 266835015364 H-loop/switch region; other site 266835015365 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 266835015366 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835015367 TM-ABC transporter signature motif; other site 266835015368 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 266835015369 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266835015370 putative ligand binding site [chemical binding]; other site 266835015371 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835015372 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835015373 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835015374 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835015375 Helix-turn-helix domains; Region: HTH; cl00088 266835015376 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 266835015377 putative dimerization interface [polypeptide binding]; other site 266835015378 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 266835015379 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266835015380 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 266835015381 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 266835015382 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 266835015383 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 266835015384 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 266835015385 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835015386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835015387 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835015388 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835015389 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835015390 putative DNA binding site [nucleotide binding]; other site 266835015391 putative Zn2+ binding site [ion binding]; other site 266835015392 Helix-turn-helix domains; Region: HTH; cl00088 266835015393 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266835015394 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835015395 Walker A/P-loop; other site 266835015396 ATP binding site [chemical binding]; other site 266835015397 Q-loop/lid; other site 266835015398 ABC transporter signature motif; other site 266835015399 Walker B; other site 266835015400 D-loop; other site 266835015401 H-loop/switch region; other site 266835015402 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835015403 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835015404 Walker A/P-loop; other site 266835015405 ATP binding site [chemical binding]; other site 266835015406 Q-loop/lid; other site 266835015407 ABC transporter signature motif; other site 266835015408 Walker B; other site 266835015409 D-loop; other site 266835015410 H-loop/switch region; other site 266835015411 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835015412 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266835015413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835015414 dimer interface [polypeptide binding]; other site 266835015415 conserved gate region; other site 266835015416 ABC-ATPase subunit interface; other site 266835015417 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835015418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835015419 dimer interface [polypeptide binding]; other site 266835015420 conserved gate region; other site 266835015421 putative PBP binding loops; other site 266835015422 ABC-ATPase subunit interface; other site 266835015423 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835015424 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 266835015425 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266835015426 hypothetical protein; Provisional; Region: PRK05965 266835015427 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835015428 inhibitor-cofactor binding pocket; inhibition site 266835015429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835015430 catalytic residue [active] 266835015431 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835015432 Coenzyme A binding pocket [chemical binding]; other site 266835015433 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 266835015434 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266835015435 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835015436 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835015437 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835015438 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266835015439 tetramerization interface [polypeptide binding]; other site 266835015440 NAD(P) binding site [chemical binding]; other site 266835015441 catalytic residues [active] 266835015442 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 266835015443 tartrate dehydrogenase; Provisional; Region: PRK08194 266835015444 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 266835015445 NAD(P) binding site [chemical binding]; other site 266835015446 catalytic residues [active] 266835015447 Cupin domain; Region: Cupin_2; cl09118 266835015448 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266835015449 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835015450 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 266835015451 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 266835015452 metal binding site [ion binding]; metal-binding site 266835015453 putative dimer interface [polypeptide binding]; other site 266835015454 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835015455 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 266835015456 Helix-turn-helix domains; Region: HTH; cl00088 266835015457 The C-terminal substrate binding domain of LysR-type transcriptional regulator HcaR in involved in 3-phenylpropionic acid catabolism, contains the type2 periplasmic binding fold; Region: PBP2_HcaR; cd08450 266835015458 putative dimerization interface [polypeptide binding]; other site 266835015459 putative substrate binding pocket [chemical binding]; other site 266835015460 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 266835015461 classical (c) SDRs; Region: SDR_c; cd05233 266835015462 NAD(P) binding site [chemical binding]; other site 266835015463 active site 266835015464 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266835015465 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 266835015466 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835015467 NAD(P) binding site [chemical binding]; other site 266835015468 active site 266835015469 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835015470 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 266835015471 putative C-terminal domain interface [polypeptide binding]; other site 266835015472 putative GSH binding site (G-site) [chemical binding]; other site 266835015473 putative dimer interface [polypeptide binding]; other site 266835015474 C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182 266835015475 putative N-terminal domain interface [polypeptide binding]; other site 266835015476 putative dimer interface [polypeptide binding]; other site 266835015477 putative substrate binding pocket (H-site) [chemical binding]; other site 266835015478 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835015479 active site 266835015480 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835015481 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835015482 DNA-binding site [nucleotide binding]; DNA binding site 266835015483 FCD domain; Region: FCD; cl11656 266835015484 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 266835015485 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 266835015486 putative ligand binding site [chemical binding]; other site 266835015487 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266835015488 TM-ABC transporter signature motif; other site 266835015489 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266835015490 TM-ABC transporter signature motif; other site 266835015491 Isochorismatase family; Region: Isochorismatase; pfam00857 266835015492 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 266835015493 catalytic triad [active] 266835015494 conserved cis-peptide bond; other site 266835015495 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 266835015496 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 266835015497 Walker A/P-loop; other site 266835015498 ATP binding site [chemical binding]; other site 266835015499 Q-loop/lid; other site 266835015500 ABC transporter signature motif; other site 266835015501 Walker B; other site 266835015502 D-loop; other site 266835015503 H-loop/switch region; other site 266835015504 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 266835015505 Isochorismatase family; Region: Isochorismatase; pfam00857 266835015506 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 266835015507 catalytic triad [active] 266835015508 conserved cis-peptide bond; other site 266835015509 Cupin domain; Region: Cupin_2; cl09118 266835015510 amidohydrolase, AtzE family; Region: amido_AtzE; TIGR02715 266835015511 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 266835015512 Lysozyme family protein [General function prediction only]; Region: COG5526 266835015513 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 266835015514 Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_1; cd09819 266835015515 putative heme binding site [chemical binding]; other site 266835015516 putative substrate binding site [chemical binding]; other site 266835015517 Uncharacterized conserved protein [Function unknown]; Region: COG1944; cl09146 266835015518 YcaO-like family; Region: YcaO; pfam02624 266835015519 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 266835015520 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 266835015521 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 266835015522 TPR motif; other site 266835015523 binding surface 266835015524 Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_1; cd09819 266835015525 putative heme binding site [chemical binding]; other site 266835015526 putative substrate binding site [chemical binding]; other site 266835015527 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 266835015528 catalytic residues [active] 266835015529 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266835015530 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835015531 DNA-binding site [nucleotide binding]; DNA binding site 266835015532 FCD domain; Region: FCD; cl11656 266835015533 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835015534 TM-ABC transporter signature motif; other site 266835015535 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835015536 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 266835015537 Walker A/P-loop; other site 266835015538 ATP binding site [chemical binding]; other site 266835015539 Q-loop/lid; other site 266835015540 ABC transporter signature motif; other site 266835015541 Walker B; other site 266835015542 D-loop; other site 266835015543 H-loop/switch region; other site 266835015544 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 266835015545 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 266835015546 ligand binding site [chemical binding]; other site 266835015547 short chain dehydrogenase; Provisional; Region: PRK07063 266835015548 classical (c) SDRs; Region: SDR_c; cd05233 266835015549 NAD(P) binding site [chemical binding]; other site 266835015550 active site 266835015551 galactonate dehydratase; Provisional; Region: PRK14017 266835015552 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 266835015553 putative active site pocket [active] 266835015554 putative metal binding site [ion binding]; other site 266835015555 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 266835015556 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835015557 putative metal binding site [ion binding]; other site 266835015558 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266835015559 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266835015560 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266835015561 active site 266835015562 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266835015563 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 266835015564 metal binding site [ion binding]; metal-binding site 266835015565 substrate binding pocket [chemical binding]; other site 266835015566 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835015567 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835015568 DNA-binding site [nucleotide binding]; DNA binding site 266835015569 FCD domain; Region: FCD; cl11656 266835015570 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835015571 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835015572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835015573 dimer interface [polypeptide binding]; other site 266835015574 conserved gate region; other site 266835015575 putative PBP binding loops; other site 266835015576 ABC-ATPase subunit interface; other site 266835015577 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835015578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835015579 dimer interface [polypeptide binding]; other site 266835015580 conserved gate region; other site 266835015581 putative PBP binding loops; other site 266835015582 ABC-ATPase subunit interface; other site 266835015583 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266835015584 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 266835015585 Walker A/P-loop; other site 266835015586 ATP binding site [chemical binding]; other site 266835015587 Q-loop/lid; other site 266835015588 ABC transporter signature motif; other site 266835015589 Walker B; other site 266835015590 D-loop; other site 266835015591 H-loop/switch region; other site 266835015592 TOBE domain; Region: TOBE_2; cl01440 266835015593 choline dehydrogenase; Validated; Region: PRK02106 266835015594 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835015595 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266835015596 Predicted esterase [General function prediction only]; Region: COG0627 266835015597 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835015598 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 266835015599 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835015600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835015601 FAD dependent oxidoreductase; Region: DAO; pfam01266 266835015602 histidinol-phosphate aminotransferase; Provisional; Region: PRK05166 266835015603 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835015604 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835015605 homodimer interface [polypeptide binding]; other site 266835015606 catalytic residue [active] 266835015607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835015608 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266835015609 NAD(P) binding site [chemical binding]; other site 266835015610 active site 266835015611 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 266835015612 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 266835015613 NAD binding site [chemical binding]; other site 266835015614 dimerization interface [polypeptide binding]; other site 266835015615 product binding site; other site 266835015616 substrate binding site [chemical binding]; other site 266835015617 zinc binding site [ion binding]; other site 266835015618 catalytic residues [active] 266835015619 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 266835015620 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 266835015621 NAD(P) binding site [chemical binding]; other site 266835015622 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 266835015623 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835015624 DNA-binding site [nucleotide binding]; DNA binding site 266835015625 UTRA domain; Region: UTRA; cl01230 266835015626 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266835015627 NMT1-like family; Region: NMT1_2; cl15260 266835015628 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266835015629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835015630 dimer interface [polypeptide binding]; other site 266835015631 conserved gate region; other site 266835015632 putative PBP binding loops; other site 266835015633 ABC-ATPase subunit interface; other site 266835015634 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266835015635 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 266835015636 Walker A/P-loop; other site 266835015637 ATP binding site [chemical binding]; other site 266835015638 Q-loop/lid; other site 266835015639 ABC transporter signature motif; other site 266835015640 Walker B; other site 266835015641 D-loop; other site 266835015642 H-loop/switch region; other site 266835015643 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266835015644 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 266835015645 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 266835015646 Walker A/P-loop; other site 266835015647 ATP binding site [chemical binding]; other site 266835015648 Q-loop/lid; other site 266835015649 ABC transporter signature motif; other site 266835015650 Walker B; other site 266835015651 D-loop; other site 266835015652 H-loop/switch region; other site 266835015653 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266835015654 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 266835015655 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835015656 Walker A/P-loop; other site 266835015657 ATP binding site [chemical binding]; other site 266835015658 Q-loop/lid; other site 266835015659 ABC transporter signature motif; other site 266835015660 Walker B; other site 266835015661 D-loop; other site 266835015662 H-loop/switch region; other site 266835015663 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835015664 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835015665 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 266835015666 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835015667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 266835015668 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 266835015669 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 266835015670 active sites [active] 266835015671 tetramer interface [polypeptide binding]; other site 266835015672 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 266835015673 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266835015674 putative NAD(P) binding site [chemical binding]; other site 266835015675 hypothetical protein; Provisional; Region: PRK07482 266835015676 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835015677 inhibitor-cofactor binding pocket; inhibition site 266835015678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835015679 catalytic residue [active] 266835015680 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835015681 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266835015682 tetramerization interface [polypeptide binding]; other site 266835015683 NAD(P) binding site [chemical binding]; other site 266835015684 catalytic residues [active] 266835015685 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835015686 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835015687 putative DNA binding site [nucleotide binding]; other site 266835015688 putative Zn2+ binding site [ion binding]; other site 266835015689 Helix-turn-helix domains; Region: HTH; cl00088 266835015690 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266835015691 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835015692 DNA-binding site [nucleotide binding]; DNA binding site 266835015693 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835015694 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835015695 homodimer interface [polypeptide binding]; other site 266835015696 catalytic residue [active] 266835015697 ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005 266835015698 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835015699 Walker A/P-loop; other site 266835015700 ATP binding site [chemical binding]; other site 266835015701 Q-loop/lid; other site 266835015702 ABC transporter signature motif; other site 266835015703 Walker B; other site 266835015704 D-loop; other site 266835015705 H-loop/switch region; other site 266835015706 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 266835015707 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835015708 substrate binding pocket [chemical binding]; other site 266835015709 membrane-bound complex binding site; other site 266835015710 hinge residues; other site 266835015711 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266835015712 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835015713 dimer interface [polypeptide binding]; other site 266835015714 conserved gate region; other site 266835015715 putative PBP binding loops; other site 266835015716 ABC-ATPase subunit interface; other site 266835015717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835015718 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266835015719 dimer interface [polypeptide binding]; other site 266835015720 conserved gate region; other site 266835015721 putative PBP binding loops; other site 266835015722 ABC-ATPase subunit interface; other site 266835015723 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 266835015724 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 266835015725 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 266835015726 tetramer interface [polypeptide binding]; other site 266835015727 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835015728 catalytic residue [active] 266835015729 ectoine utilization protein EutC; Validated; Region: PRK08291 266835015730 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835015731 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 266835015732 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266835015733 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266835015734 active site 266835015735 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 266835015736 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 266835015737 putative active site [active] 266835015738 Zn binding site [ion binding]; other site 266835015739 OpgC protein; Region: OpgC_C; cl00792 266835015740 Acyltransferase family; Region: Acyl_transf_3; pfam01757 266835015741 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835015742 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835015743 DNA-binding site [nucleotide binding]; DNA binding site 266835015744 FCD domain; Region: FCD; cl11656 266835015745 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 266835015746 active site 2 [active] 266835015747 active site 1 [active] 266835015748 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835015749 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835015750 Domain of unknown function (DUF718); Region: DUF718; cl01281 266835015751 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266835015752 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266835015753 active site pocket [active] 266835015754 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266835015755 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 266835015756 Walker A/P-loop; other site 266835015757 ATP binding site [chemical binding]; other site 266835015758 Q-loop/lid; other site 266835015759 ABC transporter signature motif; other site 266835015760 Walker B; other site 266835015761 D-loop; other site 266835015762 H-loop/switch region; other site 266835015763 TOBE domain; Region: TOBE_2; cl01440 266835015764 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835015765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835015766 dimer interface [polypeptide binding]; other site 266835015767 conserved gate region; other site 266835015768 putative PBP binding loops; other site 266835015769 ABC-ATPase subunit interface; other site 266835015770 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835015771 dimer interface [polypeptide binding]; other site 266835015772 conserved gate region; other site 266835015773 putative PBP binding loops; other site 266835015774 ABC-ATPase subunit interface; other site 266835015775 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835015776 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835015777 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266835015778 Helix-turn-helix domains; Region: HTH; cl00088 266835015779 Bacterial transcriptional regulator; Region: IclR; pfam01614 266835015780 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 266835015781 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266835015782 active site 266835015783 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835015784 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266835015785 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266835015786 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 266835015787 active site 2 [active] 266835015788 active site 1 [active] 266835015789 Tim44-like domain; Region: Tim44; cl09208 266835015790 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 266835015791 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 266835015792 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266835015793 putative NAD(P) binding site [chemical binding]; other site 266835015794 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835015795 Helix-turn-helix domains; Region: HTH; cl00088 266835015796 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 266835015797 putative effector binding pocket; other site 266835015798 putative dimerization interface [polypeptide binding]; other site 266835015799 acetolactate synthase; Reviewed; Region: PRK08322 266835015800 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266835015801 PYR/PP interface [polypeptide binding]; other site 266835015802 dimer interface [polypeptide binding]; other site 266835015803 TPP binding site [chemical binding]; other site 266835015804 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 266835015805 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 266835015806 TPP-binding site [chemical binding]; other site 266835015807 dimer interface [polypeptide binding]; other site 266835015808 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835015809 acetylornithine deacetylase; Validated; Region: PRK06915 266835015810 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 266835015811 metal binding site [ion binding]; metal-binding site 266835015812 dimer interface [polypeptide binding]; other site 266835015813 Phosphotransferase enzyme family; Region: APH; pfam01636 266835015814 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 266835015815 active site 266835015816 ATP binding site [chemical binding]; other site 266835015817 substrate binding site [chemical binding]; other site 266835015818 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 266835015819 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835015820 inhibitor-cofactor binding pocket; inhibition site 266835015821 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835015822 catalytic residue [active] 266835015823 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835015824 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835015825 DNA-binding site [nucleotide binding]; DNA binding site 266835015826 FCD domain; Region: FCD; cl11656 266835015827 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835015828 FAD dependent oxidoreductase; Region: DAO; pfam01266 266835015829 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266835015830 TM-ABC transporter signature motif; other site 266835015831 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266835015832 TM-ABC transporter signature motif; other site 266835015833 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266835015834 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 266835015835 Walker A/P-loop; other site 266835015836 ATP binding site [chemical binding]; other site 266835015837 Q-loop/lid; other site 266835015838 ABC transporter signature motif; other site 266835015839 Walker B; other site 266835015840 D-loop; other site 266835015841 H-loop/switch region; other site 266835015842 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266835015843 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 266835015844 Walker A/P-loop; other site 266835015845 ATP binding site [chemical binding]; other site 266835015846 Q-loop/lid; other site 266835015847 ABC transporter signature motif; other site 266835015848 Walker B; other site 266835015849 D-loop; other site 266835015850 H-loop/switch region; other site 266835015851 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835015852 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835015853 DNA-binding site [nucleotide binding]; DNA binding site 266835015854 FCD domain; Region: FCD; cl11656 266835015855 Domain of unknown function (DUF369); Region: DUF369; cl00950 266835015856 TIGR04076 family protein; Region: TIGR04076 266835015857 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 266835015858 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835015859 active site 266835015860 catalytic tetrad [active] 266835015861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 266835015862 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266835015863 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346 266835015864 putative ligand binding site [chemical binding]; other site 266835015865 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266835015866 FAD binding domain; Region: FAD_binding_4; pfam01565 266835015867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835015868 conserved gate region; other site 266835015869 dimer interface [polypeptide binding]; other site 266835015870 putative PBP binding loops; other site 266835015871 ABC-ATPase subunit interface; other site 266835015872 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835015873 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835015874 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835015875 Walker A/P-loop; other site 266835015876 ATP binding site [chemical binding]; other site 266835015877 Q-loop/lid; other site 266835015878 ABC transporter signature motif; other site 266835015879 Walker B; other site 266835015880 D-loop; other site 266835015881 H-loop/switch region; other site 266835015882 TOBE domain; Region: TOBE_2; cl01440 266835015883 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835015884 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 266835015885 short chain dehydrogenase; Provisional; Region: PRK12939 266835015886 classical (c) SDRs; Region: SDR_c; cd05233 266835015887 NAD(P) binding site [chemical binding]; other site 266835015888 active site 266835015889 Dehydratase family; Region: ILVD_EDD; cl00340 266835015890 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266835015891 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835015892 DNA-binding site [nucleotide binding]; DNA binding site 266835015893 FCD domain; Region: FCD; cl11656 266835015894 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 266835015895 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 266835015896 active site 266835015897 catalytic residues [active] 266835015898 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835015899 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 266835015900 NAD(P) binding site [chemical binding]; other site 266835015901 catalytic residues [active] 266835015902 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835015903 NAD(P) binding site [chemical binding]; other site 266835015904 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 266835015905 active site 266835015906 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266835015907 TM-ABC transporter signature motif; other site 266835015908 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266835015909 TM-ABC transporter signature motif; other site 266835015910 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266835015911 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 266835015912 Walker A/P-loop; other site 266835015913 ATP binding site [chemical binding]; other site 266835015914 Q-loop/lid; other site 266835015915 ABC transporter signature motif; other site 266835015916 Walker B; other site 266835015917 D-loop; other site 266835015918 H-loop/switch region; other site 266835015919 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266835015920 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 266835015921 Walker A/P-loop; other site 266835015922 ATP binding site [chemical binding]; other site 266835015923 Q-loop/lid; other site 266835015924 ABC transporter signature motif; other site 266835015925 Walker B; other site 266835015926 D-loop; other site 266835015927 H-loop/switch region; other site 266835015928 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_4; cd06337 266835015929 putative ligand binding site [chemical binding]; other site 266835015930 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 266835015931 Helix-turn-helix domains; Region: HTH; cl00088 266835015932 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835015933 dimerization interface [polypeptide binding]; other site 266835015934 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 266835015935 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266835015936 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 266835015937 multimer interface [polypeptide binding]; other site 266835015938 heterodimer interface [polypeptide binding]; other site 266835015939 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 266835015940 active site 266835015941 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 266835015942 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 266835015943 heterodimer interface [polypeptide binding]; other site 266835015944 active site 266835015945 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 266835015946 tetramer interface [polypeptide binding]; other site 266835015947 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 266835015948 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835015949 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835015950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835015951 dimer interface [polypeptide binding]; other site 266835015952 conserved gate region; other site 266835015953 ABC-ATPase subunit interface; other site 266835015954 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 266835015955 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266835015956 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 266835015957 substrate binding site [chemical binding]; other site 266835015958 ATP binding site [chemical binding]; other site 266835015959 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266835015960 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835015961 DNA binding site [nucleotide binding] 266835015962 domain linker motif; other site 266835015963 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266835015964 dimerization interface [polypeptide binding]; other site 266835015965 ligand binding site [chemical binding]; other site 266835015966 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266835015967 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835015968 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835015969 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835015970 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266835015971 Helix-turn-helix domains; Region: HTH; cl00088 266835015972 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 266835015973 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 266835015974 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 266835015975 putative active site; other site 266835015976 catalytic residue [active] 266835015977 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266835015978 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 266835015979 substrate binding site [chemical binding]; other site 266835015980 ATP binding site [chemical binding]; other site 266835015981 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266835015982 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 266835015983 Walker A/P-loop; other site 266835015984 ATP binding site [chemical binding]; other site 266835015985 Q-loop/lid; other site 266835015986 ABC transporter signature motif; other site 266835015987 Walker B; other site 266835015988 D-loop; other site 266835015989 H-loop/switch region; other site 266835015990 TOBE domain; Region: TOBE_2; cl01440 266835015991 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835015992 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835015993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835015994 dimer interface [polypeptide binding]; other site 266835015995 conserved gate region; other site 266835015996 putative PBP binding loops; other site 266835015997 ABC-ATPase subunit interface; other site 266835015998 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835015999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835016000 dimer interface [polypeptide binding]; other site 266835016001 conserved gate region; other site 266835016002 putative PBP binding loops; other site 266835016003 ABC-ATPase subunit interface; other site 266835016004 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 266835016005 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835016006 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835016007 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266835016008 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835016009 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 266835016010 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 266835016011 substrate binding site [chemical binding]; other site 266835016012 hexamer interface [polypeptide binding]; other site 266835016013 metal binding site [ion binding]; metal-binding site 266835016014 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 266835016015 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 266835016016 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 266835016017 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266835016018 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835016019 Q-loop/lid; other site 266835016020 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 266835016021 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 266835016022 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835016023 dimer interface [polypeptide binding]; other site 266835016024 phosphorylation site [posttranslational modification] 266835016025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835016026 ATP binding site [chemical binding]; other site 266835016027 Mg2+ binding site [ion binding]; other site 266835016028 G-X-G motif; other site 266835016029 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 266835016030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835016031 active site 266835016032 phosphorylation site [posttranslational modification] 266835016033 intermolecular recognition site; other site 266835016034 dimerization interface [polypeptide binding]; other site 266835016035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835016036 Walker A motif; other site 266835016037 ATP binding site [chemical binding]; other site 266835016038 Walker B motif; other site 266835016039 arginine finger; other site 266835016040 Helix-turn-helix domains; Region: HTH; cl00088 266835016041 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835016042 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 266835016043 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 266835016044 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266835016045 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835016046 Walker A/P-loop; other site 266835016047 ATP binding site [chemical binding]; other site 266835016048 Q-loop/lid; other site 266835016049 ABC transporter signature motif; other site 266835016050 Walker B; other site 266835016051 D-loop; other site 266835016052 H-loop/switch region; other site 266835016053 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835016054 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835016055 Walker A/P-loop; other site 266835016056 ATP binding site [chemical binding]; other site 266835016057 Q-loop/lid; other site 266835016058 ABC transporter signature motif; other site 266835016059 Walker B; other site 266835016060 D-loop; other site 266835016061 H-loop/switch region; other site 266835016062 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835016063 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266835016064 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835016065 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835016066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835016067 dimer interface [polypeptide binding]; other site 266835016068 conserved gate region; other site 266835016069 putative PBP binding loops; other site 266835016070 ABC-ATPase subunit interface; other site 266835016071 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835016072 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516 266835016073 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: PRK12570 266835016074 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 266835016075 putative active site [active] 266835016076 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 266835016077 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 266835016078 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 266835016079 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 266835016080 hinge; other site 266835016081 active site 266835016082 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 266835016083 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 266835016084 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266835016085 putative active site [active] 266835016086 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 266835016087 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266835016088 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835016089 DNA-binding site [nucleotide binding]; DNA binding site 266835016090 FCD domain; Region: FCD; cl11656 266835016091 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 266835016092 nucleotide binding site [chemical binding]; other site 266835016093 SulA interaction site; other site 266835016094 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 266835016095 metal ion-dependent adhesion site (MIDAS); other site 266835016096 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 266835016097 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 266835016098 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835016099 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835016100 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835016101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835016102 dimer interface [polypeptide binding]; other site 266835016103 conserved gate region; other site 266835016104 putative PBP binding loops; other site 266835016105 ABC-ATPase subunit interface; other site 266835016106 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835016107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835016108 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266835016109 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835016110 Walker A/P-loop; other site 266835016111 ATP binding site [chemical binding]; other site 266835016112 Q-loop/lid; other site 266835016113 ABC transporter signature motif; other site 266835016114 Walker B; other site 266835016115 D-loop; other site 266835016116 H-loop/switch region; other site 266835016117 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266835016118 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 266835016119 Walker A/P-loop; other site 266835016120 ATP binding site [chemical binding]; other site 266835016121 Q-loop/lid; other site 266835016122 ABC transporter signature motif; other site 266835016123 Walker B; other site 266835016124 D-loop; other site 266835016125 H-loop/switch region; other site 266835016126 TOBE domain; Region: TOBE_2; cl01440 266835016127 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 266835016128 L-xylulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 266835016129 putative N- and C-terminal domain interface [polypeptide binding]; other site 266835016130 putative active site [active] 266835016131 putative MgATP binding site [chemical binding]; other site 266835016132 catalytic site [active] 266835016133 metal binding site [ion binding]; metal-binding site 266835016134 putative xylulose binding site [chemical binding]; other site 266835016135 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266835016136 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835016137 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 266835016138 Uncharacterized conserved protein [Function unknown]; Region: COG3347 266835016139 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 266835016140 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 266835016141 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 266835016142 hypothetical protein; Provisional; Region: PRK08185 266835016143 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 266835016144 intersubunit interface [polypeptide binding]; other site 266835016145 active site 266835016146 zinc binding site [ion binding]; other site 266835016147 Na+ binding site [ion binding]; other site 266835016148 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266835016149 Helix-turn-helix domains; Region: HTH; cl00088 266835016150 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 266835016151 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 266835016152 substrate binding site [chemical binding]; other site 266835016153 dimer interface [polypeptide binding]; other site 266835016154 catalytic triad [active] 266835016155 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 266835016156 DAK2 domain; Region: Dak2; cl03685 266835016157 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 266835016158 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 266835016159 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208 266835016160 active site 266835016161 homopentamer interface [polypeptide binding]; other site 266835016162 dimer interface [polypeptide binding]; other site 266835016163 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266835016164 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835016165 Helix-turn-helix domains; Region: HTH; cl00088 266835016166 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 266835016167 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 266835016168 Phosphotransferase enzyme family; Region: APH; pfam01636 266835016169 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266835016170 active site 266835016171 substrate binding site [chemical binding]; other site 266835016172 ATP binding site [chemical binding]; other site 266835016173 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266835016174 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835016175 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 266835016176 Walker A/P-loop; other site 266835016177 ATP binding site [chemical binding]; other site 266835016178 Q-loop/lid; other site 266835016179 ABC transporter signature motif; other site 266835016180 Walker B; other site 266835016181 D-loop; other site 266835016182 H-loop/switch region; other site 266835016183 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 266835016184 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835016185 TM-ABC transporter signature motif; other site 266835016186 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 266835016187 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266835016188 putative ligand binding site [chemical binding]; other site 266835016189 short chain dehydrogenase; Validated; Region: PRK08324 266835016190 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 266835016191 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835016192 NAD(P) binding site [chemical binding]; other site 266835016193 active site 266835016194 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 266835016195 Helix-turn-helix domains; Region: HTH; cl00088 266835016196 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 266835016197 acyl-CoA synthetase; Validated; Region: PRK08162 266835016198 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 266835016199 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 266835016200 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 266835016201 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835016202 Helix-turn-helix domains; Region: HTH; cl00088 266835016203 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266835016204 putative membrane fusion protein; Region: TIGR02828 266835016205 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 266835016206 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266835016207 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266835016208 active site 266835016209 non-prolyl cis peptide bond; other site 266835016210 Amino acid permease; Region: AA_permease; cl00524 266835016211 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 266835016212 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835016213 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 266835016214 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 266835016215 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835016216 Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767 266835016217 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 266835016218 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835016219 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 266835016220 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266835016221 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 266835016222 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 266835016223 active site 266835016224 FMN binding site [chemical binding]; other site 266835016225 substrate binding site [chemical binding]; other site 266835016226 3Fe-4S cluster binding site [ion binding]; other site 266835016227 Glutamate synthase domain 3 [Amino acid transport and metabolism]; Region: GltB; COG0070 266835016228 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 266835016229 domain_subunit interface; other site 266835016230 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 266835016231 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cd00352 266835016232 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 266835016233 putative active site [active] 266835016234 ethanolamine permease; Region: 2A0305; TIGR00908 266835016235 Amino acid permease; Region: AA_permease; cl00524 266835016236 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 266835016237 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835016238 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 266835016239 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 266835016240 FMN-binding pocket [chemical binding]; other site 266835016241 flavin binding motif; other site 266835016242 phosphate binding motif [ion binding]; other site 266835016243 beta-alpha-beta structure motif; other site 266835016244 NAD binding pocket [chemical binding]; other site 266835016245 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266835016246 catalytic loop [active] 266835016247 iron binding site [ion binding]; other site 266835016248 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 266835016249 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 266835016250 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835016251 non-specific DNA binding site [nucleotide binding]; other site 266835016252 salt bridge; other site 266835016253 sequence-specific DNA binding site [nucleotide binding]; other site 266835016254 Cupin domain; Region: Cupin_2; cl09118 266835016255 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266835016256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835016257 dimer interface [polypeptide binding]; other site 266835016258 conserved gate region; other site 266835016259 putative PBP binding loops; other site 266835016260 ABC-ATPase subunit interface; other site 266835016261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835016262 dimer interface [polypeptide binding]; other site 266835016263 conserved gate region; other site 266835016264 ABC-ATPase subunit interface; other site 266835016265 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 266835016266 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 266835016267 Walker A/P-loop; other site 266835016268 ATP binding site [chemical binding]; other site 266835016269 Q-loop/lid; other site 266835016270 ABC transporter signature motif; other site 266835016271 Walker B; other site 266835016272 D-loop; other site 266835016273 H-loop/switch region; other site 266835016274 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 266835016275 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 266835016276 short chain dehydrogenase; Provisional; Region: PRK06114 266835016277 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835016278 NAD(P) binding site [chemical binding]; other site 266835016279 active site 266835016280 Domain of unknown function (DUF427); Region: DUF427; cl00998 266835016281 OpgC protein; Region: OpgC_C; cl00792 266835016282 Acyltransferase family; Region: Acyl_transf_3; pfam01757 266835016283 OpgC protein; Region: OpgC_C; cl00792 266835016284 Acyltransferase family; Region: Acyl_transf_3; pfam01757 266835016285 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835016286 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 266835016287 Probable Catalytic site; other site 266835016288 metal-binding site 266835016289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835016290 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 266835016291 active site 266835016292 Domain of unknown function (DUF427); Region: DUF427; cl00998 266835016293 Domain of unknown function (DUF427); Region: DUF427; cl00998 266835016294 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 266835016295 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 266835016296 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 266835016297 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835016298 Helix-turn-helix domains; Region: HTH; cl00088 266835016299 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266835016300 dimerization interface [polypeptide binding]; other site 266835016301 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 266835016302 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835016303 Walker A/P-loop; other site 266835016304 ATP binding site [chemical binding]; other site 266835016305 Q-loop/lid; other site 266835016306 ABC transporter signature motif; other site 266835016307 Walker B; other site 266835016308 D-loop; other site 266835016309 H-loop/switch region; other site 266835016310 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835016311 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835016312 Walker A/P-loop; other site 266835016313 ATP binding site [chemical binding]; other site 266835016314 Q-loop/lid; other site 266835016315 ABC transporter signature motif; other site 266835016316 Walker B; other site 266835016317 D-loop; other site 266835016318 H-loop/switch region; other site 266835016319 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835016320 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266835016321 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 266835016322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835016323 putative PBP binding loops; other site 266835016324 dimer interface [polypeptide binding]; other site 266835016325 ABC-ATPase subunit interface; other site 266835016326 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835016327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835016328 dimer interface [polypeptide binding]; other site 266835016329 conserved gate region; other site 266835016330 putative PBP binding loops; other site 266835016331 ABC-ATPase subunit interface; other site 266835016332 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835016333 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 266835016334 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266835016335 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266835016336 active site pocket [active] 266835016337 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266835016338 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266835016339 active site pocket [active] 266835016340 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835016341 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835016342 DNA-binding site [nucleotide binding]; DNA binding site 266835016343 FCD domain; Region: FCD; cl11656 266835016344 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835016345 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266835016346 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266835016347 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266835016348 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 266835016349 Protein export membrane protein; Region: SecD_SecF; cl14618 266835016350 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835016351 Helix-turn-helix domains; Region: HTH; cl00088 266835016352 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266835016353 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835016354 DNA binding site [nucleotide binding] 266835016355 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 266835016356 putative ligand binding site [chemical binding]; other site 266835016357 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266835016358 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835016359 Walker A/P-loop; other site 266835016360 ATP binding site [chemical binding]; other site 266835016361 Q-loop/lid; other site 266835016362 ABC transporter signature motif; other site 266835016363 Walker B; other site 266835016364 D-loop; other site 266835016365 H-loop/switch region; other site 266835016366 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835016367 TM-ABC transporter signature motif; other site 266835016368 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 266835016369 putative ligand binding site [chemical binding]; other site 266835016370 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 266835016371 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 266835016372 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 266835016373 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 266835016374 active site 266835016375 catalytic residues [active] 266835016376 classical (c) SDRs; Region: SDR_c; cd05233 266835016377 NAD(P) binding site [chemical binding]; other site 266835016378 active site 266835016379 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266835016380 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835016381 Walker A/P-loop; other site 266835016382 ATP binding site [chemical binding]; other site 266835016383 Q-loop/lid; other site 266835016384 ABC transporter signature motif; other site 266835016385 Walker B; other site 266835016386 D-loop; other site 266835016387 H-loop/switch region; other site 266835016388 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835016389 TM-ABC transporter signature motif; other site 266835016390 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266835016391 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 266835016392 putative ligand binding site [chemical binding]; other site 266835016393 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266835016394 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266835016395 active site pocket [active] 266835016396 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266835016397 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835016398 DNA-binding site [nucleotide binding]; DNA binding site 266835016399 FCD domain; Region: FCD; cl11656 266835016400 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 266835016401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835016402 dimer interface [polypeptide binding]; other site 266835016403 conserved gate region; other site 266835016404 putative PBP binding loops; other site 266835016405 ABC-ATPase subunit interface; other site 266835016406 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835016407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835016408 putative PBP binding loops; other site 266835016409 dimer interface [polypeptide binding]; other site 266835016410 ABC-ATPase subunit interface; other site 266835016411 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835016412 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835016413 Helix-turn-helix domains; Region: HTH; cl00088 266835016414 Cupin domain; Region: Cupin_2; cl09118 266835016415 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835016416 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835016417 Walker A/P-loop; other site 266835016418 ATP binding site [chemical binding]; other site 266835016419 Q-loop/lid; other site 266835016420 ABC transporter signature motif; other site 266835016421 Walker B; other site 266835016422 D-loop; other site 266835016423 H-loop/switch region; other site 266835016424 TOBE domain; Region: TOBE_2; cl01440 266835016425 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 266835016426 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266835016427 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 266835016428 ArsC family; Region: ArsC; pfam03960 266835016429 putative catalytic residues [active] 266835016430 Protein of unknown function, DUF488; Region: DUF488; cl01246 266835016431 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 266835016432 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266835016433 Helix-turn-helix domains; Region: HTH; cl00088 266835016434 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266835016435 dimerization interface [polypeptide binding]; other site 266835016436 substrate binding pocket [chemical binding]; other site 266835016437 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 266835016438 D-galactonate transporter; Region: 2A0114; TIGR00893 266835016439 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 266835016440 Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins; Region: CE4_CDA_like_3; cd10976 266835016441 NodB motif; other site 266835016442 putative active site [active] 266835016443 putative catalytic site [active] 266835016444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 266835016445 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 266835016446 GTP-binding protein Der; Reviewed; Region: PRK00093 266835016447 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 266835016448 G1 box; other site 266835016449 GTP/Mg2+ binding site [chemical binding]; other site 266835016450 Switch I region; other site 266835016451 G2 box; other site 266835016452 Switch II region; other site 266835016453 G3 box; other site 266835016454 G4 box; other site 266835016455 G5 box; other site 266835016456 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 266835016457 G1 box; other site 266835016458 GTP/Mg2+ binding site [chemical binding]; other site 266835016459 Switch I region; other site 266835016460 G2 box; other site 266835016461 G3 box; other site 266835016462 Switch II region; other site 266835016463 G4 box; other site 266835016464 G5 box; other site 266835016465 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835016466 Helix-turn-helix domains; Region: HTH; cl00088 266835016467 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835016468 dimerization interface [polypeptide binding]; other site 266835016469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835016470 putative substrate translocation pore; other site 266835016471 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 266835016472 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 266835016473 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 266835016474 ATP synthase A chain; Region: ATP-synt_A; cl00413 266835016475 ATP synthase subunit C; Region: ATP-synt_C; cl00466 266835016476 Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975 266835016477 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 266835016478 Plant ATP synthase F0; Region: YMF19; cl07975 266835016479 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 266835016480 RNA/DNA hybrid binding site [nucleotide binding]; other site 266835016481 active site 266835016482 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 266835016483 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835016484 FeS/SAM binding site; other site 266835016485 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 266835016486 MPT binding site; other site 266835016487 trimer interface [polypeptide binding]; other site 266835016488 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 266835016489 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 266835016490 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 266835016491 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 266835016492 tandem repeat interface [polypeptide binding]; other site 266835016493 oligomer interface [polypeptide binding]; other site 266835016494 active site residues [active] 266835016495 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 266835016496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835016497 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 266835016498 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 266835016499 substrate binding pocket [chemical binding]; other site 266835016500 chain length determination region; other site 266835016501 substrate-Mg2+ binding site; other site 266835016502 catalytic residues [active] 266835016503 aspartate-rich region 1; other site 266835016504 active site lid residues [active] 266835016505 aspartate-rich region 2; other site 266835016506 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835016507 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835016508 DNA-binding site [nucleotide binding]; DNA binding site 266835016509 FCD domain; Region: FCD; cl11656 266835016510 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 266835016511 Protein of unknown function (DUF1284); Region: DUF1284; cl01419 266835016512 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 266835016513 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835016514 TPR motif; other site 266835016515 binding surface 266835016516 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835016517 binding surface 266835016518 TPR motif; other site 266835016519 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835016520 binding surface 266835016521 TPR motif; other site 266835016522 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 266835016523 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835016524 Coenzyme A binding pocket [chemical binding]; other site 266835016525 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 266835016526 dimer interface [polypeptide binding]; other site 266835016527 motif 1; other site 266835016528 active site 266835016529 motif 2; other site 266835016530 motif 3; other site 266835016531 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 266835016532 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 266835016533 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 266835016534 SUA5 domain; Region: SUA5; pfam03481 266835016535 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266835016536 FAD binding domain; Region: FAD_binding_4; pfam01565 266835016537 UbiA prenyltransferase family; Region: UbiA; cl00337 266835016538 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835016539 Helix-turn-helix domains; Region: HTH; cl00088 266835016540 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 266835016541 putative substrate binding pocket [chemical binding]; other site 266835016542 dimerization interface [polypeptide binding]; other site 266835016543 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 266835016544 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 266835016545 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 266835016546 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 266835016547 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 266835016548 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 266835016549 active site 266835016550 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 266835016551 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266835016552 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266835016553 active site 266835016554 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 266835016555 enoyl-CoA hydratase; Provisional; Region: PRK06023 266835016556 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835016557 substrate binding site [chemical binding]; other site 266835016558 oxyanion hole (OAH) forming residues; other site 266835016559 trimer interface [polypeptide binding]; other site 266835016560 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 266835016561 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 266835016562 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 266835016563 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 266835016564 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266835016565 HSP70 interaction site [polypeptide binding]; other site 266835016566 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 266835016567 substrate binding site [polypeptide binding]; other site 266835016568 dimer interface [polypeptide binding]; other site 266835016569 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 266835016570 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 266835016571 NAD binding site [chemical binding]; other site 266835016572 homotetramer interface [polypeptide binding]; other site 266835016573 homodimer interface [polypeptide binding]; other site 266835016574 substrate binding site [chemical binding]; other site 266835016575 active site 266835016576 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266835016577 catalytic core [active] 266835016578 Protein of unknown function (DUF1344); Region: DUF1344; pfam07076 266835016579 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 266835016580 Tetramer interface [polypeptide binding]; other site 266835016581 active site 266835016582 FMN-binding site [chemical binding]; other site 266835016583 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 266835016584 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 266835016585 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 266835016586 dimerization interface [polypeptide binding]; other site 266835016587 active site 266835016588 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 266835016589 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835016590 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835016591 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835016592 Helix-turn-helix domains; Region: HTH; cl00088 266835016593 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 266835016594 putative FMN binding site [chemical binding]; other site 266835016595 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 266835016596 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 266835016597 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 266835016598 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 266835016599 Pirin-related protein [General function prediction only]; Region: COG1741 266835016600 Cupin domain; Region: Cupin_2; cl09118 266835016601 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 266835016602 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 266835016603 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 266835016604 TPP-binding site; other site 266835016605 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 266835016606 PYR/PP interface [polypeptide binding]; other site 266835016607 dimer interface [polypeptide binding]; other site 266835016608 TPP binding site [chemical binding]; other site 266835016609 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266835016610 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 266835016611 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 266835016612 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266835016613 RNA binding surface [nucleotide binding]; other site 266835016614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835016615 S-adenosylmethionine binding site [chemical binding]; other site 266835016616 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 266835016617 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 266835016618 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 266835016619 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 266835016620 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 266835016621 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 266835016622 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 266835016623 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 266835016624 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 266835016625 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 266835016626 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 266835016627 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 266835016628 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 266835016629 cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007 266835016630 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 266835016631 Subunit I/III interface [polypeptide binding]; other site 266835016632 D-pathway; other site 266835016633 Subunit I/VIIc interface [polypeptide binding]; other site 266835016634 Subunit I/IV interface [polypeptide binding]; other site 266835016635 Subunit I/II interface [polypeptide binding]; other site 266835016636 Low-spin heme (heme a) binding site [chemical binding]; other site 266835016637 Subunit I/VIIa interface [polypeptide binding]; other site 266835016638 Subunit I/VIa interface [polypeptide binding]; other site 266835016639 Dimer interface; other site 266835016640 Putative water exit pathway; other site 266835016641 Binuclear center (heme a3/CuB) [ion binding]; other site 266835016642 K-pathway; other site 266835016643 Subunit I/Vb interface [polypeptide binding]; other site 266835016644 Putative proton exit pathway; other site 266835016645 Subunit I/VIb interface; other site 266835016646 Subunit I/VIc interface [polypeptide binding]; other site 266835016647 Electron transfer pathway; other site 266835016648 Subunit I/VIIIb interface [polypeptide binding]; other site 266835016649 Subunit I/VIIb interface [polypeptide binding]; other site 266835016650 UbiA prenyltransferase family; Region: UbiA; cl00337 266835016651 Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; cl01240 266835016652 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 266835016653 Subunit III/VIIa interface [polypeptide binding]; other site 266835016654 Phospholipid binding site [chemical binding]; other site 266835016655 Subunit I/III interface [polypeptide binding]; other site 266835016656 Subunit III/VIb interface [polypeptide binding]; other site 266835016657 Subunit III/VIa interface; other site 266835016658 Subunit III/Vb interface [polypeptide binding]; other site 266835016659 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 266835016660 Protein of unknown function (DUF983); Region: DUF983; cl02211 266835016661 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 266835016662 LytB protein; Region: LYTB; cl00507 266835016663 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 266835016664 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 266835016665 Phosphotransferase enzyme family; Region: APH; pfam01636 266835016666 putative active site [active] 266835016667 putative substrate binding site [chemical binding]; other site 266835016668 ATP binding site [chemical binding]; other site 266835016669 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 266835016670 RNA/DNA hybrid binding site [nucleotide binding]; other site 266835016671 active site 266835016672 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 266835016673 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 266835016674 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 266835016675 catalytic triad [active] 266835016676 dimer interface [polypeptide binding]; other site 266835016677 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 266835016678 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 266835016679 PAS fold; Region: PAS_3; pfam08447 266835016680 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 266835016681 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835016682 metal binding site [ion binding]; metal-binding site 266835016683 active site 266835016684 I-site; other site 266835016685 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835016686 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 266835016687 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835016688 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 266835016689 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 266835016690 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 266835016691 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 266835016692 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 266835016693 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835016694 catalytic residue [active] 266835016695 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 266835016696 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266835016697 motif II; other site 266835016698 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 266835016699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835016700 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835016701 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 266835016702 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266835016703 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 266835016704 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 266835016705 minor groove reading motif; other site 266835016706 helix-hairpin-helix signature motif; other site 266835016707 substrate binding pocket [chemical binding]; other site 266835016708 active site 266835016709 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 266835016710 DNA binding and oxoG recognition site [nucleotide binding] 266835016711 Protein of unknown function (DUF721); Region: DUF721; cl02324 266835016712 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 266835016713 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 266835016714 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 266835016715 Walker A/P-loop; other site 266835016716 ATP binding site [chemical binding]; other site 266835016717 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 266835016718 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 266835016719 ABC transporter signature motif; other site 266835016720 Walker B; other site 266835016721 D-loop; other site 266835016722 H-loop/switch region; other site 266835016723 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835016724 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 266835016725 pyruvate phosphate dikinase; Provisional; Region: PRK09279 266835016726 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 266835016727 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 266835016728 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 266835016729 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 266835016730 Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955 266835016731 NodB motif; other site 266835016732 putative active site [active] 266835016733 putative catalytic site [active] 266835016734 Domain of unknown function (DUF427); Region: DUF427; cl00998 266835016735 putative acyl-CoA synthetase; Provisional; Region: PRK06018 266835016736 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 266835016737 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 266835016738 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266835016739 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835016740 DNA binding site [nucleotide binding] 266835016741 domain linker motif; other site 266835016742 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 266835016743 ligand binding site [chemical binding]; other site 266835016744 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835016745 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835016746 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835016747 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 266835016748 Walker A/P-loop; other site 266835016749 ATP binding site [chemical binding]; other site 266835016750 Q-loop/lid; other site 266835016751 ABC transporter signature motif; other site 266835016752 Walker B; other site 266835016753 D-loop; other site 266835016754 H-loop/switch region; other site 266835016755 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835016756 dimer interface [polypeptide binding]; other site 266835016757 conserved gate region; other site 266835016758 putative PBP binding loops; other site 266835016759 ABC-ATPase subunit interface; other site 266835016760 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835016761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835016762 dimer interface [polypeptide binding]; other site 266835016763 conserved gate region; other site 266835016764 putative PBP binding loops; other site 266835016765 ABC-ATPase subunit interface; other site 266835016766 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 266835016767 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 266835016768 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266835016769 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 266835016770 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 266835016771 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835016772 putative NAD(P) binding site [chemical binding]; other site 266835016773 active site 266835016774 putative substrate binding site [chemical binding]; other site 266835016775 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 266835016776 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 266835016777 substrate binding site; other site 266835016778 tetramer interface; other site 266835016779 Cupin domain; Region: Cupin_2; cl09118 266835016780 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 266835016781 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 266835016782 NAD binding site [chemical binding]; other site 266835016783 substrate binding site [chemical binding]; other site 266835016784 homodimer interface [polypeptide binding]; other site 266835016785 active site 266835016786 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 266835016787 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 266835016788 NADP binding site [chemical binding]; other site 266835016789 active site 266835016790 putative substrate binding site [chemical binding]; other site 266835016791 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 266835016792 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266835016793 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 266835016794 Ligand binding site; other site 266835016795 Putative Catalytic site; other site 266835016796 DXD motif; other site 266835016797 Predicted integral membrane protein [Function unknown]; Region: COG0392 266835016798 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835016799 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835016800 NAD(P) binding site [chemical binding]; other site 266835016801 active site 266835016802 Rhamnan synthesis protein F; Region: RgpF; cl01529 266835016803 Rhamnan synthesis protein F; Region: RgpF; cl01529 266835016804 Rhamnan synthesis protein F; Region: RgpF; cl01529 266835016805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 266835016806 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 266835016807 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 266835016808 Walker A/P-loop; other site 266835016809 ATP binding site [chemical binding]; other site 266835016810 Q-loop/lid; other site 266835016811 ABC transporter signature motif; other site 266835016812 Walker B; other site 266835016813 D-loop; other site 266835016814 H-loop/switch region; other site 266835016815 ABC-2 type transporter; Region: ABC2_membrane; cl11417 266835016816 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 266835016817 Probable Catalytic site; other site 266835016818 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 266835016819 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 266835016820 active site 266835016821 substrate binding site [chemical binding]; other site 266835016822 metal binding site [ion binding]; metal-binding site 266835016823 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 266835016824 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 266835016825 NAD(P) binding site [chemical binding]; other site 266835016826 homodimer interface [polypeptide binding]; other site 266835016827 substrate binding site [chemical binding]; other site 266835016828 active site 266835016829 Bacterial sugar transferase; Region: Bac_transf; cl00939 266835016830 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835016831 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 266835016832 putative NAD(P) binding site [chemical binding]; other site 266835016833 active site 266835016834 putative substrate binding site [chemical binding]; other site 266835016835 O-Antigen ligase; Region: Wzy_C; cl04850 266835016836 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 266835016837 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 266835016838 Active Sites [active] 266835016839 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 266835016840 CysN_ATPS subfamily. CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes. ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate. CysD, which...; Region: CysN_ATPS; cd04166 266835016841 CysD dimerization site [polypeptide binding]; other site 266835016842 G1 box; other site 266835016843 putative GEF interaction site [polypeptide binding]; other site 266835016844 GTP/Mg2+ binding site [chemical binding]; other site 266835016845 Switch I region; other site 266835016846 G2 box; other site 266835016847 G3 box; other site 266835016848 Switch II region; other site 266835016849 G4 box; other site 266835016850 G5 box; other site 266835016851 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 266835016852 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 266835016853 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 266835016854 ligand-binding site [chemical binding]; other site 266835016855 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 266835016856 active site 266835016857 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 266835016858 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 266835016859 inhibitor-cofactor binding pocket; inhibition site 266835016860 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835016861 catalytic residue [active] 266835016862 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 266835016863 putative substrate binding site [chemical binding]; other site 266835016864 putative ATP binding site [chemical binding]; other site 266835016865 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 266835016866 Helix-turn-helix domains; Region: HTH; cl00088 266835016867 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 266835016868 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 266835016869 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 266835016870 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266835016871 ligand binding site [chemical binding]; other site 266835016872 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835016873 TM-ABC transporter signature motif; other site 266835016874 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266835016875 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835016876 Walker A/P-loop; other site 266835016877 ATP binding site [chemical binding]; other site 266835016878 Q-loop/lid; other site 266835016879 ABC transporter signature motif; other site 266835016880 Walker B; other site 266835016881 D-loop; other site 266835016882 H-loop/switch region; other site 266835016883 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 266835016884 homodimer interface [polypeptide binding]; other site 266835016885 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 266835016886 active site pocket [active] 266835016887 glycogen branching enzyme; Provisional; Region: PRK05402 266835016888 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 266835016889 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 266835016890 active site 266835016891 catalytic site [active] 266835016892 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 266835016893 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 266835016894 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 266835016895 ligand binding site; other site 266835016896 oligomer interface; other site 266835016897 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 266835016898 dimer interface [polypeptide binding]; other site 266835016899 N-terminal domain interface [polypeptide binding]; other site 266835016900 sulfate 1 binding site; other site 266835016901 glycogen synthase; Provisional; Region: glgA; PRK00654 266835016902 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 266835016903 ADP-binding pocket [chemical binding]; other site 266835016904 homodimer interface [polypeptide binding]; other site 266835016905 phosphoglucomutase; Region: PLN02307 266835016906 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 266835016907 substrate binding site [chemical binding]; other site 266835016908 dimer interface [polypeptide binding]; other site 266835016909 active site 266835016910 metal binding site [ion binding]; metal-binding site 266835016911 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 266835016912 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 266835016913 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 266835016914 active site 266835016915 catalytic site [active] 266835016916 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 266835016917 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 266835016918 active site 266835016919 catalytic site [active] 266835016920 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 266835016921 Predicted membrane protein [Function unknown]; Region: COG4655 266835016922 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 266835016923 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 266835016924 peptide binding site [polypeptide binding]; other site 266835016925 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 266835016926 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 266835016927 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835016928 dimer interface [polypeptide binding]; other site 266835016929 conserved gate region; other site 266835016930 putative PBP binding loops; other site 266835016931 ABC-ATPase subunit interface; other site 266835016932 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 266835016933 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266835016934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835016935 dimer interface [polypeptide binding]; other site 266835016936 conserved gate region; other site 266835016937 putative PBP binding loops; other site 266835016938 ABC-ATPase subunit interface; other site 266835016939 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 266835016940 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835016941 Walker A/P-loop; other site 266835016942 ATP binding site [chemical binding]; other site 266835016943 Q-loop/lid; other site 266835016944 ABC transporter signature motif; other site 266835016945 Walker B; other site 266835016946 D-loop; other site 266835016947 H-loop/switch region; other site 266835016948 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835016949 Walker A/P-loop; other site 266835016950 ATP binding site [chemical binding]; other site 266835016951 Q-loop/lid; other site 266835016952 ABC transporter signature motif; other site 266835016953 Walker B; other site 266835016954 D-loop; other site 266835016955 H-loop/switch region; other site 266835016956 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835016957 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 266835016958 NmrA-like family; Region: NmrA; pfam05368 266835016959 NADP binding site [chemical binding]; other site 266835016960 active site 266835016961 regulatory binding site [polypeptide binding]; other site 266835016962 LysR family transcriptional regulator; Provisional; Region: PRK14997 266835016963 Helix-turn-helix domains; Region: HTH; cl00088 266835016964 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266835016965 putative effector binding pocket; other site 266835016966 dimerization interface [polypeptide binding]; other site 266835016967 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 266835016968 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 266835016969 Substrate binding site; other site 266835016970 Cupin domain; Region: Cupin_2; cl09118 266835016971 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 266835016972 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 266835016973 dimerization interface [polypeptide binding]; other site 266835016974 putative active cleft [active] 266835016975 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835016976 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 266835016977 tetrameric interface [polypeptide binding]; other site 266835016978 NAD binding site [chemical binding]; other site 266835016979 catalytic residues [active] 266835016980 choline dehydrogenase; Validated; Region: PRK02106 266835016981 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266835016982 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 266835016983 tetramer interface [polypeptide binding]; other site 266835016984 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835016985 catalytic residue [active] 266835016986 choline-sulfatase; Region: chol_sulfatase; TIGR03417 266835016987 Sulfatase; Region: Sulfatase; cl10460 266835016988 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 266835016989 transcriptional regulator BetI; Validated; Region: PRK00767 266835016990 Helix-turn-helix domains; Region: HTH; cl00088 266835016991 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 266835016992 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 266835016993 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266835016994 active site 266835016995 L-asparaginase II; Region: Asparaginase_II; cl01842 266835016996 twin-arg-translocated uncharacterized repeat protein; Region: RR_plus_rpt_1; TIGR03808 266835016997 transcription elongation factor regulatory protein; Validated; Region: PRK06342 266835016998 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 266835016999 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 266835017000 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 266835017001 active site 266835017002 substrate binding site [chemical binding]; other site 266835017003 coenzyme B12 binding site [chemical binding]; other site 266835017004 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 266835017005 B12 binding site [chemical binding]; other site 266835017006 cobalt ligand [ion binding]; other site 266835017007 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 266835017008 heterodimer interface [polypeptide binding]; other site 266835017009 substrate interaction site [chemical binding]; other site 266835017010 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 266835017011 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266835017012 motif II; other site 266835017013 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835017014 DNA binding site [nucleotide binding] 266835017015 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266835017016 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 266835017017 putative ligand binding site [chemical binding]; other site 266835017018 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 266835017019 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 266835017020 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266835017021 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 266835017022 putative ligand binding site [chemical binding]; other site 266835017023 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835017024 TM-ABC transporter signature motif; other site 266835017025 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 266835017026 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 266835017027 Walker A/P-loop; other site 266835017028 ATP binding site [chemical binding]; other site 266835017029 Q-loop/lid; other site 266835017030 ABC transporter signature motif; other site 266835017031 Walker B; other site 266835017032 D-loop; other site 266835017033 H-loop/switch region; other site 266835017034 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 266835017035 [2Fe-2S] cluster binding site [ion binding]; other site 266835017036 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 266835017037 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 266835017038 DNA interaction; other site 266835017039 Metal-binding active site; metal-binding site 266835017040 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 266835017041 oligomerization interface [polypeptide binding]; other site 266835017042 active site 266835017043 metal binding site [ion binding]; metal-binding site 266835017044 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 266835017045 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 266835017046 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266835017047 motif II; other site 266835017048 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 266835017049 homodimer interface [polypeptide binding]; other site 266835017050 substrate-cofactor binding pocket; other site 266835017051 Aminotransferase class IV; Region: Aminotran_4; pfam01063 266835017052 catalytic residue [active] 266835017053 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 266835017054 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 266835017055 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 266835017056 Cytochrome C'; Region: Cytochrom_C_2; cl01610 266835017057 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266835017058 SET domain; Region: SET; cl02566 266835017059 LysE type translocator; Region: LysE; cl00565 266835017060 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 266835017061 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 266835017062 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; cl11561 266835017063 Fe-S metabolism associated domain; Region: SufE; cl00951 266835017064 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 266835017065 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835017066 dimer interface [polypeptide binding]; other site 266835017067 phosphorylation site [posttranslational modification] 266835017068 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835017069 ATP binding site [chemical binding]; other site 266835017070 Mg2+ binding site [ion binding]; other site 266835017071 G-X-G motif; other site 266835017072 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 266835017073 His-Xaa-Ser repeat protein HxsA; Region: His_Ser_Rich; TIGR03979 266835017074 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 266835017075 Protein of unknown function (DUF1491); Region: DUF1491; cl11568 266835017076 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; cl15419 266835017077 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 266835017078 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 266835017079 Transglycosylase; Region: Transgly; cl07896 266835017080 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 266835017081 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 266835017082 allantoate amidohydrolase; Reviewed; Region: PRK12893 266835017083 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 266835017084 active site 266835017085 metal binding site [ion binding]; metal-binding site 266835017086 dimer interface [polypeptide binding]; other site 266835017087 BtpA family; Region: BtpA; cl00440 266835017088 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 266835017089 substrate binding site [chemical binding]; other site 266835017090 dimer interface [polypeptide binding]; other site 266835017091 ATP binding site [chemical binding]; other site 266835017092 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 266835017093 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 266835017094 active site 266835017095 substrate binding pocket [chemical binding]; other site 266835017096 homodimer interaction site [polypeptide binding]; other site 266835017097 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835017098 TM-ABC transporter signature motif; other site 266835017099 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 266835017100 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 266835017101 Walker A/P-loop; other site 266835017102 ATP binding site [chemical binding]; other site 266835017103 Q-loop/lid; other site 266835017104 ABC transporter signature motif; other site 266835017105 Walker B; other site 266835017106 D-loop; other site 266835017107 H-loop/switch region; other site 266835017108 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 266835017109 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266835017110 ligand binding site [chemical binding]; other site 266835017111 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 266835017112 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835017113 non-specific DNA binding site [nucleotide binding]; other site 266835017114 salt bridge; other site 266835017115 sequence-specific DNA binding site [nucleotide binding]; other site 266835017116 Cupin domain; Region: Cupin_2; cl09118 266835017117 Amidinotransferase; Region: Amidinotransf; cl12043 266835017118 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 266835017119 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 266835017120 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 266835017121 metal binding site [ion binding]; metal-binding site 266835017122 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266835017123 Helix-turn-helix domains; Region: HTH; cl00088 266835017124 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266835017125 dimerization interface [polypeptide binding]; other site 266835017126 substrate binding pocket [chemical binding]; other site 266835017127 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835017128 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835017129 Walker A/P-loop; other site 266835017130 ATP binding site [chemical binding]; other site 266835017131 Q-loop/lid; other site 266835017132 ABC transporter signature motif; other site 266835017133 Walker B; other site 266835017134 D-loop; other site 266835017135 H-loop/switch region; other site 266835017136 TOBE domain; Region: TOBE_2; cl01440 266835017137 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835017138 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835017139 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835017140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835017141 dimer interface [polypeptide binding]; other site 266835017142 ABC-ATPase subunit interface; other site 266835017143 putative PBP binding loops; other site 266835017144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835017145 dimer interface [polypeptide binding]; other site 266835017146 conserved gate region; other site 266835017147 putative PBP binding loops; other site 266835017148 ABC-ATPase subunit interface; other site 266835017149 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 266835017150 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835017151 NAD(P) binding site [chemical binding]; other site 266835017152 active site 266835017153 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835017154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835017155 active site 266835017156 phosphorylation site [posttranslational modification] 266835017157 intermolecular recognition site; other site 266835017158 dimerization interface [polypeptide binding]; other site 266835017159 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835017160 DNA binding site [nucleotide binding] 266835017161 sensor protein PhoQ; Provisional; Region: PRK10815 266835017162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835017163 ATP binding site [chemical binding]; other site 266835017164 G-X-G motif; other site 266835017165 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 266835017166 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 266835017167 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 266835017168 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 266835017169 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 266835017170 CcmE; Region: CcmE; cl00994 266835017171 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 266835017172 Cytochrome C biogenesis protein; Region: CcmH; cl01179 266835017173 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 266835017174 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 266835017175 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266835017176 protein binding site [polypeptide binding]; other site 266835017177 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266835017178 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835017179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835017180 active site 266835017181 phosphorylation site [posttranslational modification] 266835017182 intermolecular recognition site; other site 266835017183 dimerization interface [polypeptide binding]; other site 266835017184 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835017185 DNA binding site [nucleotide binding] 266835017186 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266835017187 dimerization interface [polypeptide binding]; other site 266835017188 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835017189 dimer interface [polypeptide binding]; other site 266835017190 phosphorylation site [posttranslational modification] 266835017191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835017192 ATP binding site [chemical binding]; other site 266835017193 Mg2+ binding site [ion binding]; other site 266835017194 G-X-G motif; other site 266835017195 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 266835017196 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 266835017197 metal binding triad; other site 266835017198 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 266835017199 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 266835017200 metal binding triad; other site 266835017201 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 266835017202 PAS fold; Region: PAS_7; pfam12860 266835017203 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835017204 dimer interface [polypeptide binding]; other site 266835017205 phosphorylation site [posttranslational modification] 266835017206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835017207 ATP binding site [chemical binding]; other site 266835017208 Mg2+ binding site [ion binding]; other site 266835017209 G-X-G motif; other site 266835017210 aminopeptidase N; Provisional; Region: pepN; PRK14015 266835017211 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 266835017212 active site 266835017213 Zn binding site [ion binding]; other site 266835017214 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266835017215 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 266835017216 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266835017217 EamA-like transporter family; Region: EamA; cl01037 266835017218 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266835017219 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835017220 non-specific DNA binding site [nucleotide binding]; other site 266835017221 salt bridge; other site 266835017222 sequence-specific DNA binding site [nucleotide binding]; other site 266835017223 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 266835017224 Fe-S cluster binding site [ion binding]; other site 266835017225 active site 266835017226 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 266835017227 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835017228 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 266835017229 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 266835017230 Bacterial protein of unknown function (DUF922); Region: DUF922; cl02415 266835017231 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 266835017232 putative catalytic site [active] 266835017233 putative metal binding site [ion binding]; other site 266835017234 putative phosphate binding site [ion binding]; other site 266835017235 AMP nucleosidase; Provisional; Region: PRK08292 266835017236 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 266835017237 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 266835017238 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 266835017239 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266835017240 Sel1 repeat; Region: Sel1; cl02723 266835017241 leucine ABC transporter subunit substrate-binding protein LivK; Provisional; Region: PRK15404 266835017242 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 266835017243 dimerization interface [polypeptide binding]; other site 266835017244 ligand binding site [chemical binding]; other site 266835017245 Spore Coat Protein U domain; Region: SCPU; cl02253 266835017246 Spore Coat Protein U domain; Region: SCPU; cl02253 266835017247 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 266835017248 Fimbrial Usher protein; Region: Usher; cl14650 266835017249 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; cl15716 266835017250 Spore Coat Protein U domain; Region: SCPU; cl02253 266835017251 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 266835017252 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266835017253 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 266835017254 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 266835017255 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266835017256 carboxyltransferase (CT) interaction site; other site 266835017257 biotinylation site [posttranslational modification]; other site 266835017258 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 266835017259 putative ADP-ribose binding site [chemical binding]; other site 266835017260 putative active site [active] 266835017261 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 266835017262 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 266835017263 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 266835017264 isovaleryl-CoA dehydrogenase; Region: PLN02519 266835017265 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 266835017266 substrate binding site [chemical binding]; other site 266835017267 FAD binding site [chemical binding]; other site 266835017268 catalytic base [active] 266835017269 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835017270 Helix-turn-helix domains; Region: HTH; cl00088 266835017271 Acylphosphatase; Region: Acylphosphatase; cl00551 266835017272 Helix-turn-helix domains; Region: HTH; cl00088 266835017273 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 266835017274 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835017275 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835017276 homodimer interface [polypeptide binding]; other site 266835017277 catalytic residue [active] 266835017278 Porin subfamily; Region: Porin_2; pfam02530 266835017279 Porin subfamily; Region: Porin_2; pfam02530 266835017280 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 266835017281 Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family. They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797 266835017282 dimer interface [polypeptide binding]; other site 266835017283 Int/Topo IB signature motif; other site 266835017284 active site 266835017285 catalytic residues [active] 266835017286 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835017287 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266835017288 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 266835017289 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266835017290 catalytic residue [active] 266835017291 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 266835017292 dihydrodipicolinate synthase; Region: dapA; TIGR00674 266835017293 dimer interface [polypeptide binding]; other site 266835017294 active site 266835017295 catalytic residue [active] 266835017296 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 266835017297 SmpB-tmRNA interface; other site 266835017298 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 266835017299 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 266835017300 active site 266835017301 Helix-turn-helix domains; Region: HTH; cl00088 266835017302 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 266835017303 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 266835017304 putative NAD(P) binding site [chemical binding]; other site 266835017305 dimer interface [polypeptide binding]; other site 266835017306 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 266835017307 Fe-S cluster binding site [ion binding]; other site 266835017308 DNA binding site [nucleotide binding] 266835017309 active site 266835017310 Uncharacterized conserved protein [Function unknown]; Region: COG1432 266835017311 LabA_like proteins; Region: LabA; cd10911 266835017312 putative metal binding site [ion binding]; other site 266835017313 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 266835017314 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 266835017315 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 266835017316 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 266835017317 synthetase active site [active] 266835017318 NTP binding site [chemical binding]; other site 266835017319 metal binding site [ion binding]; metal-binding site 266835017320 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 266835017321 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 266835017322 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 266835017323 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 266835017324 dimer interface [polypeptide binding]; other site 266835017325 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835017326 metal binding site [ion binding]; metal-binding site 266835017327 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 266835017328 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 266835017329 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 266835017330 Catalytic site [active] 266835017331 conjugative transfer signal peptidase TraF; Region: TraF_Ti; TIGR02771 266835017332 signal peptidase I; Provisional; Region: PRK10861 266835017333 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 266835017334 ribonuclease III; Reviewed; Region: PRK12371 266835017335 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 266835017336 dimerization interface [polypeptide binding]; other site 266835017337 active site 266835017338 metal binding site [ion binding]; metal-binding site 266835017339 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 266835017340 dsRNA binding site [nucleotide binding]; other site 266835017341 GTPase Era; Reviewed; Region: era; PRK00089 266835017342 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 266835017343 G1 box; other site 266835017344 GTP/Mg2+ binding site [chemical binding]; other site 266835017345 Switch I region; other site 266835017346 G2 box; other site 266835017347 Switch II region; other site 266835017348 G3 box; other site 266835017349 G4 box; other site 266835017350 G5 box; other site 266835017351 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 266835017352 Porin subfamily; Region: Porin_2; pfam02530 266835017353 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 266835017354 Recombination protein O N terminal; Region: RecO_N; cl15812 266835017355 Recombination protein O C terminal; Region: RecO_C; pfam02565 266835017356 Predicted membrane protein [Function unknown]; Region: COG5373 266835017357 Predicted membrane protein [Function unknown]; Region: COG5373 266835017358 RNA polymerase sigma factor; Provisional; Region: PRK12511 266835017359 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835017360 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835017361 DNA binding residues [nucleotide binding] 266835017362 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 266835017363 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 266835017364 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835017365 Coenzyme A binding pocket [chemical binding]; other site 266835017366 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 266835017367 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 266835017368 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 266835017369 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 266835017370 Helix-turn-helix domains; Region: HTH; cl00088 266835017371 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266835017372 dimerization interface [polypeptide binding]; other site 266835017373 substrate binding pocket [chemical binding]; other site 266835017374 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 266835017375 Fatty acid desaturase; Region: FA_desaturase; pfam00487 266835017376 putative di-iron ligands [ion binding]; other site 266835017377 similar to Predicted dehydrogenase 266835017378 LysR family transcriptional regulator; Provisional; Region: PRK14997 266835017379 Helix-turn-helix domains; Region: HTH; cl00088 266835017380 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266835017381 putative effector binding pocket; other site 266835017382 dimerization interface [polypeptide binding]; other site 266835017383 PAS fold; Region: PAS_7; pfam12860 266835017384 PAS fold; Region: PAS_7; pfam12860 266835017385 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835017386 metal binding site [ion binding]; metal-binding site 266835017387 active site 266835017388 I-site; other site 266835017389 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835017390 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 266835017391 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 266835017392 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 266835017393 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835017394 dihydroorotase; Validated; Region: PRK09060 266835017395 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266835017396 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 266835017397 active site 266835017398 Protein of unknown function (DUF2385); Region: DUF2385; cl11490 266835017399 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 266835017400 nudix motif; other site 266835017401 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 266835017402 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 266835017403 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 266835017404 active site 266835017405 HIGH motif; other site 266835017406 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 266835017407 KMSKS motif; other site 266835017408 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 266835017409 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 266835017410 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835017411 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 266835017412 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 266835017413 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 266835017414 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 266835017415 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 266835017416 active site 266835017417 catalytic residues [active] 266835017418 metal binding site [ion binding]; metal-binding site 266835017419 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 266835017420 Predicted permeases [General function prediction only]; Region: RarD; COG2962 266835017421 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 266835017422 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 266835017423 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 266835017424 Helix-turn-helix domains; Region: HTH; cl00088 266835017425 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266835017426 dimerization interface [polypeptide binding]; other site 266835017427 substrate binding pocket [chemical binding]; other site 266835017428 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 266835017429 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 266835017430 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 266835017431 putative peptidoglycan binding site; other site 266835017432 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 266835017433 Helix-turn-helix domains; Region: HTH; cl00088 266835017434 LysR family transcriptional regulator; Provisional; Region: PRK14997 266835017435 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266835017436 putative effector binding pocket; other site 266835017437 dimerization interface [polypeptide binding]; other site 266835017438 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835017439 dimerization interface [polypeptide binding]; other site 266835017440 putative DNA binding site [nucleotide binding]; other site 266835017441 putative Zn2+ binding site [ion binding]; other site 266835017442 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 266835017443 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 266835017444 ATM1 is an ABC transporter that is expressed in the mitochondria. Although the specific function of ATM1 is unknown, its disruption results in the accumulation of excess mitochondrial iron, loss of mitochondrial cytochromes, oxidative damage to...; Region: ABCC_ATM1_transporter; cd03253 266835017445 Walker A/P-loop; other site 266835017446 ATP binding site [chemical binding]; other site 266835017447 Q-loop/lid; other site 266835017448 ABC transporter signature motif; other site 266835017449 Walker B; other site 266835017450 D-loop; other site 266835017451 H-loop/switch region; other site 266835017452 Benyvirus P25/P26 protein; Region: Benyvirus_P25; pfam05744 266835017453 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 266835017454 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 266835017455 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 266835017456 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 266835017457 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835017458 putative acyl-acceptor binding pocket; other site 266835017459 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266835017460 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 266835017461 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 266835017462 Helix-turn-helix domains; Region: HTH; cl00088 266835017463 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835017464 dimerization interface [polypeptide binding]; other site 266835017465 EamA-like transporter family; Region: EamA; cl01037 266835017466 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 266835017467 EamA-like transporter family; Region: EamA; cl01037 266835017468 OsmC-like protein; Region: OsmC; cl00767 266835017469 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266835017470 classical (c) SDRs; Region: SDR_c; cd05233 266835017471 NAD(P) binding site [chemical binding]; other site 266835017472 active site 266835017473 amidophosphoribosyltransferase; Provisional; Region: PRK09123 266835017474 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 266835017475 active site 266835017476 tetramer interface [polypeptide binding]; other site 266835017477 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 266835017478 Colicin V production protein; Region: Colicin_V; cl00567 266835017479 DNA repair protein RadA; Provisional; Region: PRK11823 266835017480 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835017481 Walker A motif; other site 266835017482 ATP binding site [chemical binding]; other site 266835017483 Walker B motif; other site 266835017484 replicative DNA helicase; Provisional; Region: PRK09165 266835017485 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 266835017486 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 266835017487 Walker A motif; other site 266835017488 ATP binding site [chemical binding]; other site 266835017489 Walker B motif; other site 266835017490 DNA binding loops [nucleotide binding] 266835017491 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 266835017492 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 266835017493 YCII-related domain; Region: YCII; cl00999 266835017494 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 266835017495 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 266835017496 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835017497 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 266835017498 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 266835017499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835017500 S-adenosylmethionine binding site [chemical binding]; other site 266835017501 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 266835017502 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 266835017503 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 266835017504 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 266835017505 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 266835017506 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 266835017507 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 266835017508 metal ion-dependent adhesion site (MIDAS); other site 266835017509 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 266835017510 metal ion-dependent adhesion site (MIDAS); other site 266835017511 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 266835017512 Sulfatase; Region: Sulfatase; cl10460 266835017513 Acyl transferase domain; Region: Acyl_transf_1; cl08282 266835017514 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 266835017515 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 266835017516 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 266835017517 NAD(P) binding site [chemical binding]; other site 266835017518 homotetramer interface [polypeptide binding]; other site 266835017519 homodimer interface [polypeptide binding]; other site 266835017520 active site 266835017521 Phosphopantetheine attachment site; Region: PP-binding; cl09936 266835017522 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 266835017523 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 266835017524 dimer interface [polypeptide binding]; other site 266835017525 active site 266835017526 YceG-like family; Region: YceG; pfam02618 266835017527 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 266835017528 dimerization interface [polypeptide binding]; other site 266835017529 hypothetical protein; Provisional; Region: PRK11820 266835017530 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 266835017531 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 266835017532 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 266835017533 catalytic site [active] 266835017534 G-X2-G-X-G-K; other site 266835017535 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 266835017536 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835017537 S-adenosylmethionine binding site [chemical binding]; other site 266835017538 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 266835017539 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 266835017540 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 266835017541 SurA N-terminal domain; Region: SurA_N_3; cl07813 266835017542 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 266835017543 OstA-like protein; Region: OstA; cl00844 266835017544 Organic solvent tolerance protein; Region: OstA_C; pfam04453 266835017545 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 266835017546 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 266835017547 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 266835017548 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 266835017549 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 266835017550 multifunctional aminopeptidase A; Provisional; Region: PRK00913 266835017551 interface (dimer of trimers) [polypeptide binding]; other site 266835017552 Substrate-binding/catalytic site; other site 266835017553 Zn-binding sites [ion binding]; other site 266835017554 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 266835017555 Protein of unknown function (DUF995); Region: DUF995; pfam06191 266835017556 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 266835017557 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 266835017558 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 266835017559 DXD motif; other site 266835017560 Protein of unknown function (DUF995); Region: DUF995; pfam06191 266835017561 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 266835017562 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 266835017563 NAD binding site [chemical binding]; other site 266835017564 homodimer interface [polypeptide binding]; other site 266835017565 active site 266835017566 substrate binding site [chemical binding]; other site 266835017567 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 266835017568 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835017569 NAD binding site [chemical binding]; other site 266835017570 putative substrate binding site 2 [chemical binding]; other site 266835017571 putative substrate binding site 1 [chemical binding]; other site 266835017572 active site 266835017573 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266835017574 Helix-turn-helix domains; Region: HTH; cl00088 266835017575 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 266835017576 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 266835017577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835017578 Helix-turn-helix domain; Region: HTH_18; pfam12833 266835017579 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835017580 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 266835017581 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 266835017582 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835017583 Helix-turn-helix domains; Region: HTH; cl00088 266835017584 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 266835017585 LysE type translocator; Region: LysE; cl00565 266835017586 Helix-turn-helix domains; Region: HTH; cl00088 266835017587 putative glutathione S-transferase; Provisional; Region: PRK10357 266835017588 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 266835017589 putative C-terminal domain interface [polypeptide binding]; other site 266835017590 putative GSH binding site (G-site) [chemical binding]; other site 266835017591 putative dimer interface [polypeptide binding]; other site 266835017592 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 266835017593 dimer interface [polypeptide binding]; other site 266835017594 N-terminal domain interface [polypeptide binding]; other site 266835017595 putative substrate binding pocket (H-site) [chemical binding]; other site 266835017596 Surface antigen; Region: Surface_Ag_2; cl01155 266835017597 pteridine reductase; Provisional; Region: PRK09135 266835017598 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 266835017599 NADP binding site [chemical binding]; other site 266835017600 substrate binding pocket [chemical binding]; other site 266835017601 active site 266835017602 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 266835017603 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 266835017604 GIY-YIG motif/motif A; other site 266835017605 active site 266835017606 catalytic site [active] 266835017607 putative DNA binding site [nucleotide binding]; other site 266835017608 metal binding site [ion binding]; metal-binding site 266835017609 UvrB/uvrC motif; Region: UVR; pfam02151 266835017610 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 266835017611 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 266835017612 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 266835017613 MoaE interaction surface [polypeptide binding]; other site 266835017614 MoeB interaction surface [polypeptide binding]; other site 266835017615 thiocarboxylated glycine; other site 266835017616 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 266835017617 MoaE homodimer interface [polypeptide binding]; other site 266835017618 MoaD interaction [polypeptide binding]; other site 266835017619 active site residues [active] 266835017620 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 266835017621 META domain; Region: META; cl01245 266835017622 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 266835017623 active site 266835017624 multimer interface [polypeptide binding]; other site 266835017625 GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH as...; Region: GST_N_etherase_LigE; cd03038 266835017626 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835017627 putative C-terminal domain interface [polypeptide binding]; other site 266835017628 putative GSH binding site (G-site) [chemical binding]; other site 266835017629 putative dimer interface [polypeptide binding]; other site 266835017630 C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202 266835017631 putative N-terminal domain interface [polypeptide binding]; other site 266835017632 putative dimer interface [polypeptide binding]; other site 266835017633 putative substrate binding pocket (H-site) [chemical binding]; other site 266835017634 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 266835017635 DinB superfamily; Region: DinB_2; pfam12867 266835017636 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266835017637 Helix-turn-helix domains; Region: HTH; cl00088 266835017638 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266835017639 dimerization interface [polypeptide binding]; other site 266835017640 substrate binding pocket [chemical binding]; other site 266835017641 EamA-like transporter family; Region: EamA; cl01037 266835017642 Predicted transcriptional regulator [Transcription]; Region: COG4957 266835017643 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 266835017644 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 266835017645 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 266835017646 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 266835017647 ABC transporter; Region: ABC_tran_2; pfam12848 266835017648 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 266835017649 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266835017650 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266835017651 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 266835017652 molybdopterin cofactor binding site; other site 266835017653 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266835017654 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835017655 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835017656 Helix-turn-helix domains; Region: HTH; cl00088 266835017657 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 266835017658 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 266835017659 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835017660 catalytic residue [active] 266835017661 allantoate amidohydrolase; Reviewed; Region: PRK12890 266835017662 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 266835017663 active site 266835017664 metal binding site [ion binding]; metal-binding site 266835017665 dimer interface [polypeptide binding]; other site 266835017666 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 266835017667 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 266835017668 metal binding site [ion binding]; metal-binding site 266835017669 putative dimer interface [polypeptide binding]; other site 266835017670 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 266835017671 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835017672 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835017673 dihydrodipicolinate reductase; Provisional; Region: PRK00048 266835017674 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835017675 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 266835017676 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266835017677 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 266835017678 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266835017679 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 266835017680 Walker A/P-loop; other site 266835017681 ATP binding site [chemical binding]; other site 266835017682 Q-loop/lid; other site 266835017683 ABC transporter signature motif; other site 266835017684 Walker B; other site 266835017685 D-loop; other site 266835017686 H-loop/switch region; other site 266835017687 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266835017688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835017689 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 266835017690 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266835017691 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835017692 dimer interface [polypeptide binding]; other site 266835017693 phosphorylation site [posttranslational modification] 266835017694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835017695 ATP binding site [chemical binding]; other site 266835017696 Mg2+ binding site [ion binding]; other site 266835017697 G-X-G motif; other site 266835017698 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 266835017699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835017700 active site 266835017701 phosphorylation site [posttranslational modification] 266835017702 intermolecular recognition site; other site 266835017703 dimerization interface [polypeptide binding]; other site 266835017704 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835017705 DNA binding site [nucleotide binding] 266835017706 Protein of unknown function (DUF680); Region: DUF680; pfam05079 266835017707 Protein of unknown function (DUF680); Region: DUF680; pfam05079 266835017708 Protein of unknown function (DUF680); Region: DUF680; pfam05079 266835017709 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266835017710 catalytic core [active] 266835017711 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 266835017712 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 266835017713 active site 266835017714 substrate binding site [chemical binding]; other site 266835017715 cosubstrate binding site; other site 266835017716 catalytic site [active] 266835017717 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 266835017718 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 266835017719 dimerization interface [polypeptide binding]; other site 266835017720 putative ATP binding site [chemical binding]; other site 266835017721 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 266835017722 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 266835017723 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835017724 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 266835017725 transcriptional regulator; Provisional; Region: PRK10632 266835017726 Helix-turn-helix domains; Region: HTH; cl00088 266835017727 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266835017728 putative effector binding pocket; other site 266835017729 dimerization interface [polypeptide binding]; other site 266835017730 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835017731 NAD(P) binding site [chemical binding]; other site 266835017732 active site 266835017733 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266835017734 Int/Topo IB signature motif; other site 266835017735 active site 266835017736 DNA binding site [nucleotide binding] 266835017737 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 266835017738 RecT family; Region: RecT; cl04285 266835017739 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 266835017740 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 266835017741 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835017742 non-specific DNA binding site [nucleotide binding]; other site 266835017743 salt bridge; other site 266835017744 sequence-specific DNA binding site [nucleotide binding]; other site 266835017745 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; cl11480 266835017746 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 266835017747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835017748 cofactor binding site; other site 266835017749 DNA binding site [nucleotide binding] 266835017750 substrate interaction site [chemical binding]; other site 266835017751 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 266835017752 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 266835017753 active site 266835017754 Protein of unknown function (DUF1376); Region: DUF1376; cl01531 266835017755 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 266835017756 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 266835017757 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 266835017758 Uncharacterized conserved protein (DUF2280); Region: DUF2280; cl02353 266835017759 Terminase-like family; Region: Terminase_6; pfam03237 266835017760 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 266835017761 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567; cl12082 266835017762 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 266835017763 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; cl15403 266835017764 Encapsulating protein for peroxidase; Region: Linocin_M18; cl12047 266835017765 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 266835017766 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 266835017767 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 266835017768 active site 266835017769 catalytic triad [active] 266835017770 oxyanion hole [active] 266835017771 OpgC protein; Region: OpgC_C; cl00792 266835017772 Acyltransferase family; Region: Acyl_transf_3; pfam01757 266835017773 OpgC protein; Region: OpgC_C; cl00792 266835017774 Acyltransferase family; Region: Acyl_transf_3; pfam01757 266835017775 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 266835017776 Predicted lysozyme (DUF847); Region: DUF847; pfam05838 266835017777 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 266835017778 Protein of unknown function (DUF1515); Region: DUF1515; pfam07439 266835017779 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 266835017780 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 266835017781 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 266835017782 active site 266835017783 DNA binding site [nucleotide binding] 266835017784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 266835017785 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 266835017786 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835017787 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 266835017788 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 266835017789 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 266835017790 active site 266835017791 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 266835017792 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 266835017793 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 266835017794 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 266835017795 active site 266835017796 DNA binding site [nucleotide binding] 266835017797 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 266835017798 DNA binding site [nucleotide binding] 266835017799 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 266835017800 PAS domain; Region: PAS_9; pfam13426 266835017801 GAF domain; Region: GAF; cl15785 266835017802 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266835017803 GAF domain; Region: GAF; cl15785 266835017804 putative diguanylate cyclase; Provisional; Region: PRK09776 266835017805 GAF domain; Region: GAF_2; pfam13185 266835017806 GAF domain; Region: GAF; cl15785 266835017807 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835017808 dimer interface [polypeptide binding]; other site 266835017809 phosphorylation site [posttranslational modification] 266835017810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835017811 ATP binding site [chemical binding]; other site 266835017812 Mg2+ binding site [ion binding]; other site 266835017813 G-X-G motif; other site 266835017814 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266835017815 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835017816 active site 266835017817 phosphorylation site [posttranslational modification] 266835017818 intermolecular recognition site; other site 266835017819 dimerization interface [polypeptide binding]; other site 266835017820 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 266835017821 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 266835017822 Low affinity iron permease; Region: Iron_permease; cl12096 266835017823 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 266835017824 putative active site [active] 266835017825 catalytic site [active] 266835017826 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 266835017827 PLD-like domain; Region: PLDc_2; pfam13091 266835017828 putative active site [active] 266835017829 catalytic site [active] 266835017830 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 266835017831 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 266835017832 putative active site [active] 266835017833 putative metal binding site [ion binding]; other site 266835017834 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266835017835 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 266835017836 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 266835017837 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 266835017838 active site 266835017839 RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467 266835017840 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 266835017841 Walker A motif; other site 266835017842 ATP binding site [chemical binding]; other site 266835017843 Walker B motif; other site 266835017844 KaiC domain protein, Ph0284 family; Region: thermo_KaiC_1; TIGR03877 266835017845 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 266835017846 Walker A motif; other site 266835017847 ATP binding site [chemical binding]; other site 266835017848 Walker B motif; other site 266835017849 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266835017850 Histidine kinase; Region: HisKA_2; cl06527 266835017851 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266835017852 Histidine kinase; Region: HisKA_2; cl06527 266835017853 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835017854 ATP binding site [chemical binding]; other site 266835017855 Mg2+ binding site [ion binding]; other site 266835017856 G-X-G motif; other site 266835017857 Uncharacterized conserved protein [Function unknown]; Region: COG3496 266835017858 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 266835017859 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 266835017860 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835017861 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 266835017862 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835017863 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835017864 DNA binding residues [nucleotide binding] 266835017865 Transcriptional activator [Transcription]; Region: ChrR; COG3806 266835017866 Cupin domain; Region: Cupin_2; cl09118 266835017867 Phospholipid methyltransferase; Region: PEMT; cl00763 266835017868 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 266835017869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835017870 S-adenosylmethionine binding site [chemical binding]; other site 266835017871 Predicted membrane protein (DUF2177); Region: DUF2177; cl02014 266835017872 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 266835017873 DNA photolyase; Region: DNA_photolyase; pfam00875 266835017874 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 266835017875 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 266835017876 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 266835017877 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266835017878 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 266835017879 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 266835017880 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 266835017881 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 266835017882 active site 266835017883 DNA binding site [nucleotide binding] 266835017884 The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424 266835017885 DNA binding site [nucleotide binding] 266835017886 Protein of unknown function (DUF768); Region: DUF768; pfam05589 266835017887 RepB plasmid partitioning protein; Region: RepB; pfam07506 266835017888 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 266835017889 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 266835017890 catalytic residues [active] 266835017891 catalytic nucleophile [active] 266835017892 Recombinase; Region: Recombinase; pfam07508 266835017893 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835017894 Staphylococcal nuclease homologues; Region: SNc; smart00318 266835017895 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 266835017896 Catalytic site; other site 266835017897 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835017898 metal binding site [ion binding]; metal-binding site 266835017899 active site 266835017900 I-site; other site 266835017901 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266835017902 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 266835017903 transmembrane helices; other site 266835017904 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835017905 binding surface 266835017906 TPR motif; other site 266835017907 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835017908 binding surface 266835017909 TPR motif; other site 266835017910 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835017911 Helix-turn-helix domains; Region: HTH; cl00088 266835017912 enoyl-CoA hydratase; Provisional; Region: PRK05980 266835017913 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835017914 substrate binding site [chemical binding]; other site 266835017915 oxyanion hole (OAH) forming residues; other site 266835017916 trimer interface [polypeptide binding]; other site 266835017917 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 266835017918 Predicted outer membrane protein [Function unknown]; Region: COG3652 266835017919 RNA polymerase sigma factor; Provisional; Region: PRK11922 266835017920 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835017921 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835017922 DNA binding residues [nucleotide binding] 266835017923 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 266835017924 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 266835017925 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 266835017926 HPP family; Region: HPP; pfam04982 266835017927 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 266835017928 cystathionine beta-lyase; Provisional; Region: PRK05967 266835017929 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 266835017930 homodimer interface [polypeptide binding]; other site 266835017931 substrate-cofactor binding pocket; other site 266835017932 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835017933 catalytic residue [active] 266835017934 Protein of unknown function (DUF1326); Region: DUF1326; cl02375 266835017935 Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486 266835017936 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 266835017937 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 266835017938 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835017939 substrate binding pocket [chemical binding]; other site 266835017940 membrane-bound complex binding site; other site 266835017941 hinge residues; other site 266835017942 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 266835017943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835017944 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835017945 dimer interface [polypeptide binding]; other site 266835017946 conserved gate region; other site 266835017947 putative PBP binding loops; other site 266835017948 ABC-ATPase subunit interface; other site 266835017949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835017950 dimer interface [polypeptide binding]; other site 266835017951 conserved gate region; other site 266835017952 putative PBP binding loops; other site 266835017953 ABC-ATPase subunit interface; other site 266835017954 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266835017955 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 266835017956 Walker A/P-loop; other site 266835017957 ATP binding site [chemical binding]; other site 266835017958 Q-loop/lid; other site 266835017959 ABC transporter signature motif; other site 266835017960 Walker B; other site 266835017961 D-loop; other site 266835017962 H-loop/switch region; other site 266835017963 Protein of unknown function (DUF2459); Region: DUF2459; cl09819 266835017964 salicylate hydroxylase; Provisional; Region: PRK06475 266835017965 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835017966 polyphosphate kinase; Provisional; Region: PRK05443 266835017967 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 266835017968 putative domain interface [polypeptide binding]; other site 266835017969 putative active site [active] 266835017970 catalytic site [active] 266835017971 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 266835017972 putative domain interface [polypeptide binding]; other site 266835017973 putative active site [active] 266835017974 catalytic site [active] 266835017975 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 266835017976 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 266835017977 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 266835017978 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835017979 Walker A/P-loop; other site 266835017980 ATP binding site [chemical binding]; other site 266835017981 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 266835017982 putative active site [active] 266835017983 putative metal-binding site [ion binding]; other site 266835017984 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 266835017985 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835017986 Family description; Region: UvrD_C_2; cl15862 266835017987 DoxX; Region: DoxX; cl00976 266835017988 DoxX; Region: DoxX; cl00976 266835017989 fumarate hydratase; Reviewed; Region: fumC; PRK00485 266835017990 Class II fumarases; Region: Fumarase_classII; cd01362 266835017991 active site 266835017992 tetramer interface [polypeptide binding]; other site 266835017993 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 266835017994 classical (c) SDRs; Region: SDR_c; cd05233 266835017995 NAD(P) binding site [chemical binding]; other site 266835017996 active site 266835017997 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835017998 NIPSNAP; Region: NIPSNAP; pfam07978 266835017999 NIPSNAP; Region: NIPSNAP; pfam07978 266835018000 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 266835018001 Helix-turn-helix domains; Region: HTH; cl00088 266835018002 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266835018003 active site 266835018004 metal binding site [ion binding]; metal-binding site 266835018005 CsbD-like; Region: CsbD; cl15799 266835018006 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 266835018007 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835018008 putative C-terminal domain interface [polypeptide binding]; other site 266835018009 putative GSH binding site (G-site) [chemical binding]; other site 266835018010 putative dimer interface [polypeptide binding]; other site 266835018011 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 266835018012 putative substrate binding pocket (H-site) [chemical binding]; other site 266835018013 putative N-terminal domain interface [polypeptide binding]; other site 266835018014 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835018015 dimerization interface [polypeptide binding]; other site 266835018016 putative DNA binding site [nucleotide binding]; other site 266835018017 putative Zn2+ binding site [ion binding]; other site 266835018018 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 266835018019 putative hydrophobic ligand binding site [chemical binding]; other site 266835018020 YCII-related domain; Region: YCII; cl00999 266835018021 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 266835018022 DNA-binding site [nucleotide binding]; DNA binding site 266835018023 RNA-binding motif; other site 266835018024 LysE type translocator; Region: LysE; cl00565 266835018025 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266835018026 OsmC-like protein; Region: OsmC; cl00767 266835018027 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 266835018028 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266835018029 putative NAD(P) binding site [chemical binding]; other site 266835018030 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835018031 Helix-turn-helix domains; Region: HTH; cl00088 266835018032 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 266835018033 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 266835018034 ring oligomerisation interface [polypeptide binding]; other site 266835018035 ATP/Mg binding site [chemical binding]; other site 266835018036 stacking interactions; other site 266835018037 hinge regions; other site 266835018038 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 266835018039 oligomerisation interface [polypeptide binding]; other site 266835018040 mobile loop; other site 266835018041 roof hairpin; other site 266835018042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 266835018043 Helix-turn-helix domains; Region: HTH; cl00088 266835018044 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835018045 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 266835018046 FAD binding domain; Region: FAD_binding_4; pfam01565 266835018047 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 266835018048 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 266835018049 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 3; Region: PLPDE_III_DSD_D-TA_like_3; cd06814 266835018050 dimer interface [polypeptide binding]; other site 266835018051 active site 266835018052 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266835018053 substrate binding site [chemical binding]; other site 266835018054 catalytic residue [active] 266835018055 Helix-turn-helix domains; Region: HTH; cl00088 266835018056 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 266835018057 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835018058 Coenzyme A binding pocket [chemical binding]; other site 266835018059 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 266835018060 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266835018061 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 266835018062 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266835018063 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835018064 DNA binding site [nucleotide binding] 266835018065 domain linker motif; other site 266835018066 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266835018067 ligand binding site [chemical binding]; other site 266835018068 dimerization interface [polypeptide binding]; other site 266835018069 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835018070 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 266835018071 Walker A/P-loop; other site 266835018072 ATP binding site [chemical binding]; other site 266835018073 Q-loop/lid; other site 266835018074 ABC transporter signature motif; other site 266835018075 Walker B; other site 266835018076 D-loop; other site 266835018077 H-loop/switch region; other site 266835018078 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 266835018079 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835018080 TM-ABC transporter signature motif; other site 266835018081 Periplasmic binding domain of two-component sensor kinase signaling systems; Region: PBP1_sensor_kinase_like; cd06308 266835018082 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266835018083 putative ligand binding site [chemical binding]; other site 266835018084 EamA-like transporter family; Region: EamA; cl01037 266835018085 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 266835018086 EamA-like transporter family; Region: EamA; cl01037 266835018087 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 266835018088 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 266835018089 Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100 266835018090 putative binding site; other site 266835018091 PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech...; Region: PAN_APPLE; cl00112 266835018092 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 266835018093 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 266835018094 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 266835018095 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 266835018096 Walker A/P-loop; other site 266835018097 ATP binding site [chemical binding]; other site 266835018098 Q-loop/lid; other site 266835018099 ABC transporter signature motif; other site 266835018100 Walker B; other site 266835018101 D-loop; other site 266835018102 H-loop/switch region; other site 266835018103 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 266835018104 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 266835018105 putative ligand binding residues [chemical binding]; other site 266835018106 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 266835018107 ABC-ATPase subunit interface; other site 266835018108 dimer interface [polypeptide binding]; other site 266835018109 putative PBP binding regions; other site 266835018110 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266835018111 Helix-turn-helix domains; Region: HTH; cl00088 266835018112 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 266835018113 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266835018114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835018115 putative substrate translocation pore; other site 266835018116 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 266835018117 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 266835018118 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 266835018119 LysE type translocator; Region: LysE; cl00565 266835018120 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 266835018121 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 266835018122 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266835018123 motif I; other site 266835018124 active site 266835018125 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 266835018126 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 266835018127 active site 266835018128 Riboflavin kinase; Region: Flavokinase; cl03312 266835018129 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 266835018130 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 266835018131 Phosphoesterase family; Region: Phosphoesterase; cl15450 266835018132 MltA-interacting protein MipA; Region: MipA; cl01504 266835018133 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 266835018134 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266835018135 active site 266835018136 HIGH motif; other site 266835018137 nucleotide binding site [chemical binding]; other site 266835018138 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 266835018139 active site 266835018140 KMSKS motif; other site 266835018141 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 266835018142 tRNA binding surface [nucleotide binding]; other site 266835018143 anticodon binding site; other site 266835018144 DNA topoisomerase 2; Provisional; Region: PLN03237 266835018145 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 266835018146 nucleoside/Zn binding site; other site 266835018147 dimer interface [polypeptide binding]; other site 266835018148 catalytic motif [active] 266835018149 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 266835018150 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266835018151 RNA binding surface [nucleotide binding]; other site 266835018152 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 266835018153 active site 266835018154 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 266835018155 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 266835018156 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 266835018157 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 266835018158 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 266835018159 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 266835018160 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 266835018161 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 266835018162 nucleophile elbow; other site 266835018163 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 266835018164 elongation factor P; Validated; Region: PRK00529 266835018165 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 266835018166 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 266835018167 RNA binding site [nucleotide binding]; other site 266835018168 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 266835018169 RNA binding site [nucleotide binding]; other site 266835018170 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269 266835018171 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 266835018172 motif 1; other site 266835018173 dimer interface [polypeptide binding]; other site 266835018174 active site 266835018175 motif 2; other site 266835018176 motif 3; other site 266835018177 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 266835018178 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835018179 putative metal binding site [ion binding]; other site 266835018180 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 266835018181 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 266835018182 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 266835018183 active site 266835018184 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 266835018185 putative acyl-acceptor binding pocket; other site 266835018186 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 266835018187 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 266835018188 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 266835018189 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 266835018190 Uncharacterized protein conserved in bacteria (DUF2093); Region: DUF2093; cl11535 266835018191 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 266835018192 Helix-turn-helix domains; Region: HTH; cl00088 266835018193 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266835018194 dimerization interface [polypeptide binding]; other site 266835018195 substrate binding pocket [chemical binding]; other site 266835018196 EamA-like transporter family; Region: EamA; cl01037 266835018197 EamA-like transporter family; Region: EamA; cl01037 266835018198 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 266835018199 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 266835018200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835018201 ATP binding site [chemical binding]; other site 266835018202 Mg2+ binding site [ion binding]; other site 266835018203 G-X-G motif; other site 266835018204 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 266835018205 ATP binding site [chemical binding]; other site 266835018206 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 266835018207 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 266835018208 Helix-turn-helix domains; Region: HTH; cl00088 266835018209 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266835018210 dimerization interface [polypeptide binding]; other site 266835018211 substrate binding pocket [chemical binding]; other site 266835018212 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 266835018213 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835018214 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 266835018215 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 266835018216 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 266835018217 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 266835018218 active site 266835018219 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 266835018220 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 266835018221 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 266835018222 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 266835018223 putative active site [active] 266835018224 putative FMN binding site [chemical binding]; other site 266835018225 putative substrate binding site [chemical binding]; other site 266835018226 putative catalytic residue [active] 266835018227 Helix-turn-helix domains; Region: HTH; cl00088 266835018228 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 266835018229 Putative catalytic NodB homology domain of uncharacterized Mll8295 protein encoded from Rhizobium loti and its bacterial homologs; Region: CE4_Mll8295_like; cd10946 266835018230 NodB motif; other site 266835018231 putative active site [active] 266835018232 putative catalytic site [active] 266835018233 putative Zn binding site [ion binding]; other site 266835018234 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835018235 metal binding site [ion binding]; metal-binding site 266835018236 active site 266835018237 I-site; other site 266835018238 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835018239 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 266835018240 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 266835018241 substrate-cofactor binding pocket; other site 266835018242 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835018243 catalytic residue [active] 266835018244 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 266835018245 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 266835018246 NAD(P) binding site [chemical binding]; other site 266835018247 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 266835018248 Helix-turn-helix domains; Region: HTH; cl00088 266835018249 Cupin domain; Region: Cupin_2; cl09118 266835018250 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266835018251 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266835018252 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 266835018253 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 266835018254 DinB superfamily; Region: DinB_2; pfam12867 266835018255 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 266835018256 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 266835018257 dimer interface [polypeptide binding]; other site 266835018258 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 266835018259 active site 266835018260 Fe binding site [ion binding]; other site 266835018261 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835018262 Helix-turn-helix domains; Region: HTH; cl00088 266835018263 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 266835018264 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 266835018265 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 266835018266 metal binding site [ion binding]; metal-binding site 266835018267 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 266835018268 ABC-ATPase subunit interface; other site 266835018269 dimer interface [polypeptide binding]; other site 266835018270 putative PBP binding regions; other site 266835018271 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 266835018272 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 266835018273 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 266835018274 homotrimer interaction site [polypeptide binding]; other site 266835018275 putative active site [active] 266835018276 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 266835018277 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835018278 DNA-binding site [nucleotide binding]; DNA binding site 266835018279 UTRA domain; Region: UTRA; cl01230 266835018280 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 266835018281 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 266835018282 active site 266835018283 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 266835018284 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 266835018285 active site 266835018286 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 266835018287 active sites [active] 266835018288 tetramer interface [polypeptide binding]; other site 266835018289 N-formylglutamate amidohydrolase; Region: FGase; cl01522 266835018290 urocanate hydratase; Provisional; Region: PRK05414 266835018291 HutD; Region: HutD; cl01532 266835018292 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 266835018293 Uncharacterized protein conserved in bacteria (DUF2329); Region: DUF2329; pfam10091 266835018294 Putative carbohydrate binding domain; Region: CBM_X; cl05621 266835018295 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 266835018296 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 266835018297 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 266835018298 Putative carbohydrate binding domain; Region: CBM_X; cl05621 266835018299 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 266835018300 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 266835018301 cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657 266835018302 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 266835018303 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 266835018304 Walker A/P-loop; other site 266835018305 ATP binding site [chemical binding]; other site 266835018306 Q-loop/lid; other site 266835018307 ABC transporter signature motif; other site 266835018308 Walker B; other site 266835018309 D-loop; other site 266835018310 H-loop/switch region; other site 266835018311 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 266835018312 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 266835018313 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 266835018314 dimer interface [polypeptide binding]; other site 266835018315 active site 266835018316 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266835018317 substrate binding site [chemical binding]; other site 266835018318 catalytic residue [active] 266835018319 Cupin domain; Region: Cupin_2; cl09118 266835018320 RDD family; Region: RDD; cl00746 266835018321 Integral membrane protein DUF95; Region: DUF95; cl00572 266835018322 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 266835018323 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 266835018324 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 266835018325 metal ion-dependent adhesion site (MIDAS); other site 266835018326 MoxR-like ATPases [General function prediction only]; Region: COG0714 266835018327 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835018328 Walker A motif; other site 266835018329 ATP binding site [chemical binding]; other site 266835018330 Walker B motif; other site 266835018331 arginine finger; other site 266835018332 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 266835018333 Protein of unknown function (DUF975); Region: DUF975; cl10504 266835018334 Cupin domain; Region: Cupin_2; cl09118 266835018335 Predicted integral membrane protein [Function unknown]; Region: COG0392 266835018336 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 266835018337 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 266835018338 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835018339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835018340 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835018341 putative substrate translocation pore; other site 266835018342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835018343 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 266835018344 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 266835018345 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 266835018346 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 266835018347 active site 266835018348 MAPEG family; Region: MAPEG; cl09190 266835018349 OpgC protein; Region: OpgC_C; cl00792 266835018350 Acyltransferase family; Region: Acyl_transf_3; pfam01757 266835018351 ribonuclease D; Region: rnd; TIGR01388 266835018352 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 266835018353 putative active site [active] 266835018354 catalytic site [active] 266835018355 putative substrate binding site [chemical binding]; other site 266835018356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835018357 putative substrate translocation pore; other site 266835018358 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835018359 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 266835018360 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 266835018361 dimer interface [polypeptide binding]; other site 266835018362 anticodon binding site; other site 266835018363 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 266835018364 homodimer interface [polypeptide binding]; other site 266835018365 motif 1; other site 266835018366 active site 266835018367 motif 2; other site 266835018368 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 266835018369 active site 266835018370 motif 3; other site 266835018371 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 266835018372 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 266835018373 CAP-like domain; other site 266835018374 active site 266835018375 primary dimer interface [polypeptide binding]; other site 266835018376 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266835018377 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266835018378 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 266835018379 EamA-like transporter family; Region: EamA; cl01037 266835018380 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 266835018381 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 266835018382 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 266835018383 RDD family; Region: RDD; cl00746 266835018384 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 266835018385 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835018386 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266835018387 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266835018388 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 266835018389 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 266835018390 Phosphate transporter family; Region: PHO4; cl00396 266835018391 Predicted esterase [General function prediction only]; Region: COG0400 266835018392 OpgC protein; Region: OpgC_C; cl00792 266835018393 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266835018394 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835018395 DNA binding site [nucleotide binding] 266835018396 domain linker motif; other site 266835018397 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 266835018398 putative dimerization interface [polypeptide binding]; other site 266835018399 putative ligand binding site [chemical binding]; other site 266835018400 Protein of unknown function (DUF423); Region: DUF423; cl01008 266835018401 drug efflux system protein MdtG; Provisional; Region: PRK09874 266835018402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835018403 putative substrate translocation pore; other site 266835018404 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835018405 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835018406 DNA-binding site [nucleotide binding]; DNA binding site 266835018407 FCD domain; Region: FCD; cl11656 266835018408 Protein of unknown function (DUF982); Region: DUF982; pfam06169 266835018409 Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672 266835018410 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 266835018411 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835018412 active site 266835018413 catalytic tetrad [active] 266835018414 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 266835018415 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 266835018416 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 266835018417 dimer interface [polypeptide binding]; other site 266835018418 allosteric magnesium binding site [ion binding]; other site 266835018419 active site 266835018420 aspartate-rich active site metal binding site; other site 266835018421 Schiff base residues; other site 266835018422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3249 266835018423 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 266835018424 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 266835018425 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835018426 substrate binding site [chemical binding]; other site 266835018427 oxyanion hole (OAH) forming residues; other site 266835018428 trimer interface [polypeptide binding]; other site 266835018429 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266835018430 Helix-turn-helix domains; Region: HTH; cl00088 266835018431 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 266835018432 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 266835018433 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 266835018434 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 266835018435 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 266835018436 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 266835018437 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 266835018438 dimer interface [polypeptide binding]; other site 266835018439 glycine-pyridoxal phosphate binding site [chemical binding]; other site 266835018440 active site 266835018441 folate binding site [chemical binding]; other site 266835018442 GlpM protein; Region: GlpM; cl01212 266835018443 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 266835018444 ATP cone domain; Region: ATP-cone; pfam03477 266835018445 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 266835018446 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 266835018447 catalytic motif [active] 266835018448 Zn binding site [ion binding]; other site 266835018449 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 266835018450 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 266835018451 Lumazine binding domain; Region: Lum_binding; pfam00677 266835018452 Lumazine binding domain; Region: Lum_binding; pfam00677 266835018453 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 266835018454 homopentamer interface [polypeptide binding]; other site 266835018455 active site 266835018456 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 266835018457 putative RNA binding site [nucleotide binding]; other site 266835018458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835018459 putative substrate translocation pore; other site 266835018460 NMT1-like family; Region: NMT1_2; cl15260 266835018461 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 266835018462 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835018463 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 266835018464 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 266835018465 Walker A/P-loop; other site 266835018466 ATP binding site [chemical binding]; other site 266835018467 Q-loop/lid; other site 266835018468 ABC transporter signature motif; other site 266835018469 Walker B; other site 266835018470 D-loop; other site 266835018471 H-loop/switch region; other site 266835018472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835018473 putative PBP binding loops; other site 266835018474 dimer interface [polypeptide binding]; other site 266835018475 ABC-ATPase subunit interface; other site 266835018476 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 266835018477 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 266835018478 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 266835018479 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045 266835018480 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 266835018481 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 266835018482 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 266835018483 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 266835018484 dimer interface [polypeptide binding]; other site 266835018485 active site 266835018486 CoA binding pocket [chemical binding]; other site 266835018487 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 266835018488 IHF dimer interface [polypeptide binding]; other site 266835018489 IHF - DNA interface [nucleotide binding]; other site 266835018490 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 266835018491 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 266835018492 DNA binding residues [nucleotide binding] 266835018493 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 266835018494 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835018495 non-specific DNA binding site [nucleotide binding]; other site 266835018496 salt bridge; other site 266835018497 sequence-specific DNA binding site [nucleotide binding]; other site 266835018498 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 266835018499 putative deacylase active site [active] 266835018500 O-Antigen ligase; Region: Wzy_C; cl04850 266835018501 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 266835018502 Bacterial sugar transferase; Region: Bac_transf; cl00939 266835018503 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266835018504 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266835018505 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 266835018506 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 266835018507 SLBB domain; Region: SLBB; pfam10531 266835018508 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 266835018509 Chain length determinant protein; Region: Wzz; cl01623 266835018510 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835018511 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 266835018512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835018513 dimer interface [polypeptide binding]; other site 266835018514 conserved gate region; other site 266835018515 putative PBP binding loops; other site 266835018516 ABC-ATPase subunit interface; other site 266835018517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835018518 dimer interface [polypeptide binding]; other site 266835018519 conserved gate region; other site 266835018520 putative PBP binding loops; other site 266835018521 ABC-ATPase subunit interface; other site 266835018522 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835018523 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835018524 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835018525 Walker A/P-loop; other site 266835018526 ATP binding site [chemical binding]; other site 266835018527 Q-loop/lid; other site 266835018528 ABC transporter signature motif; other site 266835018529 Walker B; other site 266835018530 D-loop; other site 266835018531 H-loop/switch region; other site 266835018532 TOBE domain; Region: TOBE_2; cl01440 266835018533 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835018534 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835018535 DNA-binding site [nucleotide binding]; DNA binding site 266835018536 FCD domain; Region: FCD; cl11656 266835018537 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 266835018538 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 266835018539 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 266835018540 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 266835018541 putative active site [active] 266835018542 putative metal binding site [ion binding]; other site 266835018543 cytochrome c oxidase assembly protein; Provisional; Region: PTZ00127 266835018544 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 266835018545 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 266835018546 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 266835018547 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835018548 Arginase family; Region: Arginase; cl00306 266835018549 OpgC protein; Region: OpgC_C; cl00792 266835018550 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 266835018551 putative active site [active] 266835018552 catalytic site [active] 266835018553 putative metal binding site [ion binding]; other site 266835018554 oligomer interface [polypeptide binding]; other site 266835018555 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 266835018556 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 266835018557 23S rRNA interface [nucleotide binding]; other site 266835018558 L3 interface [polypeptide binding]; other site 266835018559 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266835018560 CoenzymeA binding site [chemical binding]; other site 266835018561 subunit interaction site [polypeptide binding]; other site 266835018562 PHB binding site; other site 266835018563 enoyl-CoA hydratase; Validated; Region: PRK08139 266835018564 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835018565 substrate binding site [chemical binding]; other site 266835018566 oxyanion hole (OAH) forming residues; other site 266835018567 trimer interface [polypeptide binding]; other site 266835018568 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835018569 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 266835018570 Predicted ATPase [General function prediction only]; Region: COG3910 266835018571 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 266835018572 Walker A/P-loop; other site 266835018573 ATP binding site [chemical binding]; other site 266835018574 Q-loop/lid; other site 266835018575 ABC transporter signature motif; other site 266835018576 Walker B; other site 266835018577 D-loop; other site 266835018578 H-loop/switch region; other site 266835018579 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835018580 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 266835018581 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 266835018582 homodimer interface [polypeptide binding]; other site 266835018583 substrate-cofactor binding pocket; other site 266835018584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835018585 catalytic residue [active] 266835018586 Cupin domain; Region: Cupin_2; cl09118 266835018587 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 266835018588 Cytochrome P450; Region: p450; cl12078 266835018589 sarcosine oxidase, monomeric form; Region: soxA_mon; TIGR01377 266835018590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835018591 Clp protease; Region: CLP_protease; pfam00574 266835018592 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 266835018593 oligomer interface [polypeptide binding]; other site 266835018594 active site residues [active] 266835018595 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 266835018596 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 266835018597 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835018598 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835018599 Walker A motif; other site 266835018600 ATP binding site [chemical binding]; other site 266835018601 Walker B motif; other site 266835018602 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 266835018603 Found in ATP-dependent protease La (LON); Region: LON; smart00464 266835018604 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 266835018605 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835018606 Walker A motif; other site 266835018607 ATP binding site [chemical binding]; other site 266835018608 Walker B motif; other site 266835018609 arginine finger; other site 266835018610 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 266835018611 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 266835018612 IHF dimer interface [polypeptide binding]; other site 266835018613 IHF - DNA interface [nucleotide binding]; other site 266835018614 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835018615 active site 266835018616 catalytic tetrad [active] 266835018617 Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane]; Region: GutQ; COG0794 266835018618 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 266835018619 tetramer interface [polypeptide binding]; other site 266835018620 active site 266835018621 Creatinine amidohydrolase; Region: Creatininase; cl00618 266835018622 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835018623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835018624 dimer interface [polypeptide binding]; other site 266835018625 conserved gate region; other site 266835018626 putative PBP binding loops; other site 266835018627 ABC-ATPase subunit interface; other site 266835018628 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 266835018629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835018630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835018631 putative PBP binding loops; other site 266835018632 dimer interface [polypeptide binding]; other site 266835018633 ABC-ATPase subunit interface; other site 266835018634 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835018635 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266835018636 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 266835018637 Walker A/P-loop; other site 266835018638 ATP binding site [chemical binding]; other site 266835018639 Q-loop/lid; other site 266835018640 ABC transporter signature motif; other site 266835018641 Walker B; other site 266835018642 D-loop; other site 266835018643 H-loop/switch region; other site 266835018644 TOBE domain; Region: TOBE_2; cl01440 266835018645 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 266835018646 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266835018647 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 266835018648 substrate binding site [chemical binding]; other site 266835018649 dimer interface [polypeptide binding]; other site 266835018650 ATP binding site [chemical binding]; other site 266835018651 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 266835018652 DNA binding site [nucleotide binding] 266835018653 Int/Topo IB signature motif; other site 266835018654 active site 266835018655 catalytic residues [active] 266835018656 Predicted transcriptional regulator [Transcription]; Region: COG2932 266835018657 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 266835018658 Catalytic site [active] 266835018659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 266835018660 cofactor binding site; other site 266835018661 DNA binding site [nucleotide binding] 266835018662 substrate interaction site [chemical binding]; other site 266835018663 Helix-turn-helix domains; Region: HTH; cl00088 266835018664 Transcription antiterminator [Transcription]; Region: NusG; COG0250 266835018665 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 266835018666 KOW motif; Region: KOW; cl00354 266835018667 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 266835018668 active site 266835018669 Helix-turn-helix domains; Region: HTH; cl00088 266835018670 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 266835018671 Phage Terminase; Region: Terminase_1; pfam03354 266835018672 Phage Terminase; Region: Terminase_1; pfam03354 266835018673 Phage-related protein [Function unknown]; Region: COG4695; cl01923 266835018674 Phage portal protein; Region: Phage_portal; pfam04860 266835018675 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 266835018676 oligomer interface [polypeptide binding]; other site 266835018677 active site residues [active] 266835018678 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 266835018679 Phage capsid family; Region: Phage_capsid; pfam05065 266835018680 Helix-turn-helix domains; Region: HTH; cl00088 266835018681 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 266835018682 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 266835018683 Predicted lysozyme (DUF847); Region: DUF847; pfam05838 266835018684 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 266835018685 Protein of unknown function (DUF1515); Region: DUF1515; pfam07439 266835018686 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835018687 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835018688 NAD(P) binding site [chemical binding]; other site 266835018689 active site 266835018690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835018691 S-adenosylmethionine binding site [chemical binding]; other site 266835018692 GtrA-like protein; Region: GtrA; cl00971 266835018693 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 266835018694 Ligand binding site; other site 266835018695 Putative Catalytic site; other site 266835018696 DXD motif; other site 266835018697 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835018698 dimerization interface [polypeptide binding]; other site 266835018699 putative DNA binding site [nucleotide binding]; other site 266835018700 putative Zn2+ binding site [ion binding]; other site 266835018701 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 266835018702 dimer interface [polypeptide binding]; other site 266835018703 substrate binding site [chemical binding]; other site 266835018704 metal binding sites [ion binding]; metal-binding site 266835018705 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 266835018706 classical (c) SDRs; Region: SDR_c; cd05233 266835018707 NAD(P) binding site [chemical binding]; other site 266835018708 active site 266835018709 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835018710 TM-ABC transporter signature motif; other site 266835018711 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266835018712 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 266835018713 ligand binding site [chemical binding]; other site 266835018714 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266835018715 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835018716 Walker A/P-loop; other site 266835018717 ATP binding site [chemical binding]; other site 266835018718 Q-loop/lid; other site 266835018719 ABC transporter signature motif; other site 266835018720 Walker B; other site 266835018721 D-loop; other site 266835018722 H-loop/switch region; other site 266835018723 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266835018724 non-specific DNA interactions [nucleotide binding]; other site 266835018725 DNA binding site [nucleotide binding] 266835018726 sequence specific DNA binding site [nucleotide binding]; other site 266835018727 putative cAMP binding site [chemical binding]; other site 266835018728 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 266835018729 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 266835018730 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 266835018731 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 266835018732 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266835018733 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266835018734 active site 266835018735 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266835018736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835018737 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266835018738 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 266835018739 Walker A/P-loop; other site 266835018740 ATP binding site [chemical binding]; other site 266835018741 Q-loop/lid; other site 266835018742 ABC transporter signature motif; other site 266835018743 Walker B; other site 266835018744 D-loop; other site 266835018745 H-loop/switch region; other site 266835018746 NMT1/THI5 like; Region: NMT1; pfam09084 266835018747 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 266835018748 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835018749 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 266835018750 active site 266835018751 metal binding site [ion binding]; metal-binding site 266835018752 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835018753 DNA-binding site [nucleotide binding]; DNA binding site 266835018754 FCD domain; Region: FCD; cl11656 266835018755 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266835018756 FAD binding domain; Region: FAD_binding_4; pfam01565 266835018757 Peptidase family M23; Region: Peptidase_M23; pfam01551 266835018758 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835018759 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835018760 NAD(P) binding site [chemical binding]; other site 266835018761 active site 266835018762 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835018763 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835018764 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835018765 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 266835018766 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266835018767 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 266835018768 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835018769 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835018770 NAD(P) binding site [chemical binding]; other site 266835018771 active site 266835018772 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266835018773 Helix-turn-helix domains; Region: HTH; cl00088 266835018774 Bacterial transcriptional regulator; Region: IclR; pfam01614 266835018775 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 266835018776 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266835018777 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266835018778 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266835018779 active site 266835018780 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835018781 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835018782 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835018783 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835018784 Walker A/P-loop; other site 266835018785 ATP binding site [chemical binding]; other site 266835018786 Q-loop/lid; other site 266835018787 ABC transporter signature motif; other site 266835018788 Walker B; other site 266835018789 D-loop; other site 266835018790 H-loop/switch region; other site 266835018791 TOBE domain; Region: TOBE_2; cl01440 266835018792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835018793 dimer interface [polypeptide binding]; other site 266835018794 conserved gate region; other site 266835018795 putative PBP binding loops; other site 266835018796 ABC-ATPase subunit interface; other site 266835018797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835018798 dimer interface [polypeptide binding]; other site 266835018799 conserved gate region; other site 266835018800 putative PBP binding loops; other site 266835018801 ABC-ATPase subunit interface; other site 266835018802 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 266835018803 Amidase; Region: Amidase; cl11426 266835018804 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 266835018805 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 266835018806 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835018807 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835018808 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 266835018809 Integrase core domain; Region: rve; cl01316 266835018810 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 266835018811 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 266835018812 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 266835018813 catalytic residues [active] 266835018814 catalytic nucleophile [active] 266835018815 Presynaptic Site I dimer interface [polypeptide binding]; other site 266835018816 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 266835018817 Synaptic Flat tetramer interface [polypeptide binding]; other site 266835018818 Synaptic Site I dimer interface [polypeptide binding]; other site 266835018819 DNA binding site [nucleotide binding] 266835018820 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 266835018821 DNA-binding interface [nucleotide binding]; DNA binding site 266835018822 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 266835018823 Transposase; Region: DDE_Tnp_ISL3; pfam01610 266835018824 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835018825 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835018826 DNA-binding site [nucleotide binding]; DNA binding site 266835018827 FCD domain; Region: FCD; cl11656 266835018828 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 266835018829 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266835018830 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 266835018831 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 266835018832 Uncharacterized conserved protein [Function unknown]; Region: COG3246 266835018833 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 266835018834 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266835018835 classical (c) SDRs; Region: SDR_c; cd05233 266835018836 NAD(P) binding site [chemical binding]; other site 266835018837 active site 266835018838 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266835018839 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336 266835018840 putative ligand binding site [chemical binding]; other site 266835018841 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266835018842 TM-ABC transporter signature motif; other site 266835018843 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266835018844 TM-ABC transporter signature motif; other site 266835018845 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266835018846 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 266835018847 Walker A/P-loop; other site 266835018848 ATP binding site [chemical binding]; other site 266835018849 Q-loop/lid; other site 266835018850 ABC transporter signature motif; other site 266835018851 Walker B; other site 266835018852 D-loop; other site 266835018853 H-loop/switch region; other site 266835018854 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266835018855 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 266835018856 Walker A/P-loop; other site 266835018857 ATP binding site [chemical binding]; other site 266835018858 Q-loop/lid; other site 266835018859 ABC transporter signature motif; other site 266835018860 Walker B; other site 266835018861 D-loop; other site 266835018862 H-loop/switch region; other site 266835018863 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266835018864 active site 266835018865 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835018866 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835018867 Integrase core domain; Region: rve; cl01316 266835018868 Integrase core domain; Region: rve; cl01316 266835018869 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835018870 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835018871 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835018872 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835018873 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835018874 DNA-binding site [nucleotide binding]; DNA binding site 266835018875 FCD domain; Region: FCD; cl11656 266835018876 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266835018877 AMP-binding enzyme; Region: AMP-binding; cl15778 266835018878 AMP-binding enzyme; Region: AMP-binding; cl15778 266835018879 Phosphopantetheine attachment site; Region: PP-binding; cl09936 266835018880 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 266835018881 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 266835018882 active site 266835018883 Acyl transferase domain; Region: Acyl_transf_1; cl08282 266835018884 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 266835018885 putative NADP binding site [chemical binding]; other site 266835018886 active site 266835018887 Phosphopantetheine attachment site; Region: PP-binding; cl09936 266835018888 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 266835018889 Integrase core domain; Region: rve; cl01316 266835018890 DDE domain; Region: DDE_Tnp_IS240; pfam13610 266835018891 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 266835018892 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835018893 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835018894 Restriction endonuclease; Region: Mrr_cat; cl00516 266835018895 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 266835018896 Transposase domain (DUF772); Region: DUF772; cl15789 266835018897 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 266835018898 Integrase core domain; Region: rve; cl01316 266835018899 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 266835018900 Uncharacterized conserved protein [Function unknown]; Region: COG5642 266835018901 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 266835018902 RES domain; Region: RES; cl02411 266835018903 Predicted transcriptional regulator [Transcription]; Region: COG4957 266835018904 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 266835018905 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 266835018906 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 266835018907 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835018908 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 266835018909 tetramerization interface [polypeptide binding]; other site 266835018910 active site 266835018911 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05963 266835018912 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 266835018913 dimer interface [polypeptide binding]; other site 266835018914 active site 266835018915 CoA binding pocket [chemical binding]; other site 266835018916 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 266835018917 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835018918 inhibitor-cofactor binding pocket; inhibition site 266835018919 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835018920 catalytic residue [active] 266835018921 AAA domain; Region: AAA_26; pfam13500 266835018922 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835018923 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 266835018924 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266835018925 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835018926 catalytic residue [active] 266835018927 biotin synthase; Region: bioB; TIGR00433 266835018928 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835018929 FeS/SAM binding site; other site 266835018930 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 266835018931 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 266835018932 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 266835018933 dimerization interface [polypeptide binding]; other site 266835018934 active site 266835018935 L-aspartate oxidase; Provisional; Region: PRK07512 266835018936 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835018937 domain; Region: Succ_DH_flav_C; pfam02910 266835018938 Quinolinate synthetase A protein; Region: NadA; cl00420 266835018939 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 266835018940 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 266835018941 DNA-binding site [nucleotide binding]; DNA binding site 266835018942 RNA-binding motif; other site 266835018943 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 266835018944 Uncharacterized conserved protein [Function unknown]; Region: COG3025 266835018945 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 266835018946 putative active site [active] 266835018947 putative metal binding residues [ion binding]; other site 266835018948 signature motif; other site 266835018949 putative triphosphate binding site [ion binding]; other site 266835018950 CHAD domain; Region: CHAD; cl10506 266835018951 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 266835018952 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266835018953 tetramer interface [polypeptide binding]; other site 266835018954 active site 266835018955 Mg2+/Mn2+ binding site [ion binding]; other site 266835018956 aspartate aminotransferase; Provisional; Region: PRK05764 266835018957 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835018958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835018959 homodimer interface [polypeptide binding]; other site 266835018960 catalytic residue [active] 266835018961 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 266835018962 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 266835018963 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835018964 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835018965 homodimer interface [polypeptide binding]; other site 266835018966 catalytic residue [active] 266835018967 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 266835018968 active site 266835018969 metal-binding site 266835018970 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 266835018971 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266835018972 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266835018973 active site 266835018974 non-prolyl cis peptide bond; other site 266835018975 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 266835018976 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 266835018977 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 266835018978 Ligand Binding Site [chemical binding]; other site 266835018979 Molecular Tunnel; other site 266835018980 Domain of unknown function (DUF4392); Region: DUF4392; pfam14336 266835018981 Integrase core domain; Region: rve; cl01316 266835018982 Uncharacterized conserved protein [Function unknown]; Region: COG3535 266835018983 Protein of unknown function (DUF917); Region: DUF917; pfam06032 266835018984 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266835018985 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 266835018986 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 266835018987 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835018988 Walker A/P-loop; other site 266835018989 ATP binding site [chemical binding]; other site 266835018990 Q-loop/lid; other site 266835018991 ABC transporter signature motif; other site 266835018992 Walker B; other site 266835018993 D-loop; other site 266835018994 H-loop/switch region; other site 266835018995 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835018996 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 266835018997 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835018998 Walker A/P-loop; other site 266835018999 ATP binding site [chemical binding]; other site 266835019000 Q-loop/lid; other site 266835019001 ABC transporter signature motif; other site 266835019002 Walker B; other site 266835019003 D-loop; other site 266835019004 H-loop/switch region; other site 266835019005 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835019006 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266835019007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835019008 dimer interface [polypeptide binding]; other site 266835019009 conserved gate region; other site 266835019010 putative PBP binding loops; other site 266835019011 ABC-ATPase subunit interface; other site 266835019012 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835019013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835019014 dimer interface [polypeptide binding]; other site 266835019015 conserved gate region; other site 266835019016 putative PBP binding loops; other site 266835019017 ABC-ATPase subunit interface; other site 266835019018 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835019019 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 266835019020 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266835019021 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835019022 DNA binding residues [nucleotide binding] 266835019023 dimerization interface [polypeptide binding]; other site 266835019024 cystathionine beta-lyase; Provisional; Region: PRK07050 266835019025 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266835019026 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835019027 catalytic residue [active] 266835019028 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835019029 active site 266835019030 adenylate kinase; Provisional; Region: adk; PRK02496 266835019031 Protein of unknown function (DUF1045); Region: DUF1045; cl15435 266835019032 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266835019033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835019034 dimer interface [polypeptide binding]; other site 266835019035 conserved gate region; other site 266835019036 putative PBP binding loops; other site 266835019037 ABC-ATPase subunit interface; other site 266835019038 nickel transporter permease NikB; Provisional; Region: PRK10352 266835019039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835019040 dimer interface [polypeptide binding]; other site 266835019041 conserved gate region; other site 266835019042 putative PBP binding loops; other site 266835019043 ABC-ATPase subunit interface; other site 266835019044 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 266835019045 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835019046 Walker A/P-loop; other site 266835019047 ATP binding site [chemical binding]; other site 266835019048 Q-loop/lid; other site 266835019049 ABC transporter signature motif; other site 266835019050 Walker B; other site 266835019051 D-loop; other site 266835019052 H-loop/switch region; other site 266835019053 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835019054 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266835019055 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835019056 Walker A/P-loop; other site 266835019057 ATP binding site [chemical binding]; other site 266835019058 Q-loop/lid; other site 266835019059 ABC transporter signature motif; other site 266835019060 Walker B; other site 266835019061 D-loop; other site 266835019062 H-loop/switch region; other site 266835019063 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835019064 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 266835019065 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 266835019066 active site 266835019067 metal binding site [ion binding]; metal-binding site 266835019068 hexamer interface [polypeptide binding]; other site 266835019069 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 266835019070 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 266835019071 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 266835019072 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 266835019073 Walker A/P-loop; other site 266835019074 ATP binding site [chemical binding]; other site 266835019075 Q-loop/lid; other site 266835019076 ABC transporter signature motif; other site 266835019077 Walker B; other site 266835019078 D-loop; other site 266835019079 H-loop/switch region; other site 266835019080 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 266835019081 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835019082 Walker A/P-loop; other site 266835019083 ATP binding site [chemical binding]; other site 266835019084 Q-loop/lid; other site 266835019085 ABC transporter signature motif; other site 266835019086 Walker B; other site 266835019087 D-loop; other site 266835019088 H-loop/switch region; other site 266835019089 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835019090 Phosphonate metabolism protein PhnJ; Region: PhnJ; cl01457 266835019091 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; cl01456 266835019092 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; cl01455 266835019093 Phosphonate metabolism protein PhnG; Region: PhnG; cl01454 266835019094 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 266835019095 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266835019096 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 266835019097 active site 266835019098 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 266835019099 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835019100 DNA-binding site [nucleotide binding]; DNA binding site 266835019101 UTRA domain; Region: UTRA; cl01230 266835019102 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 266835019103 putative active site [active] 266835019104 catalytic site [active] 266835019105 putative metal binding site [ion binding]; other site 266835019106 oligomer interface [polypeptide binding]; other site 266835019107 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 266835019108 PPIC-type PPIASE domain; Region: Rotamase; cl08278 266835019109 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835019110 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835019111 Protein of unknown function (DUF3624); Region: DUF3624; pfam12292 266835019112 PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech...; Region: PAN_APPLE; cl00112 266835019113 Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100 266835019114 putative binding site; other site 266835019115 PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech...; Region: PAN_APPLE; cl00112 266835019116 PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech...; Region: PAN_APPLE; cl00112 266835019117 putative binding site; other site 266835019118 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 266835019119 PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech...; Region: PAN_APPLE; cl00112 266835019120 Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100 266835019121 putative binding site; other site 266835019122 PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech...; Region: PAN_APPLE; cl00112 266835019123 putative binding site; other site 266835019124 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 266835019125 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835019126 Walker A motif; other site 266835019127 ATP binding site [chemical binding]; other site 266835019128 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457 266835019129 Sec23/Sec24 helical domain; Region: Sec23_helical; pfam04815 266835019130 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 266835019131 PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech...; Region: PAN_APPLE; cl00112 266835019132 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266835019133 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835019134 DNA binding residues [nucleotide binding] 266835019135 dimerization interface [polypeptide binding]; other site 266835019136 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 266835019137 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266835019138 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266835019139 active site 266835019140 non-prolyl cis peptide bond; other site 266835019141 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266835019142 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 266835019143 Walker A/P-loop; other site 266835019144 ATP binding site [chemical binding]; other site 266835019145 Q-loop/lid; other site 266835019146 ABC transporter signature motif; other site 266835019147 Walker B; other site 266835019148 D-loop; other site 266835019149 H-loop/switch region; other site 266835019150 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266835019151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835019152 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266835019153 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 266835019154 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835019155 metal binding site [ion binding]; metal-binding site 266835019156 active site 266835019157 I-site; other site 266835019158 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835019159 Protein of unknown function (DUF982); Region: DUF982; pfam06169 266835019160 Phd_YefM; Region: PhdYeFM; cl09153 266835019161 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 266835019162 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 266835019163 putative oxidoreductase; Provisional; Region: PRK08275 266835019164 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835019165 domain; Region: Succ_DH_flav_C; pfam02910 266835019166 adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060 266835019167 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 266835019168 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835019169 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835019170 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835019171 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266835019172 putative switch regulator; other site 266835019173 non-specific DNA interactions [nucleotide binding]; other site 266835019174 DNA binding site [nucleotide binding] 266835019175 sequence specific DNA binding site [nucleotide binding]; other site 266835019176 putative cAMP binding site [chemical binding]; other site 266835019177 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835019178 Domain of unknown function (DUF336); Region: DUF336; cl01249 266835019179 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266835019180 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266835019181 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266835019182 active site 266835019183 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 266835019184 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 266835019185 substrate-cofactor binding pocket; other site 266835019186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835019187 catalytic residue [active] 266835019188 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 266835019189 homodimer interface [polypeptide binding]; other site 266835019190 substrate-cofactor binding pocket; other site 266835019191 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835019192 Aminotransferase class IV; Region: Aminotran_4; pfam01063 266835019193 catalytic residue [active] 266835019194 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 266835019195 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 266835019196 metal binding site [ion binding]; metal-binding site 266835019197 putative dimer interface [polypeptide binding]; other site 266835019198 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266835019199 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835019200 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835019201 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 266835019202 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835019203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835019204 dimer interface [polypeptide binding]; other site 266835019205 conserved gate region; other site 266835019206 ABC-ATPase subunit interface; other site 266835019207 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 266835019208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835019209 dimer interface [polypeptide binding]; other site 266835019210 conserved gate region; other site 266835019211 ABC-ATPase subunit interface; other site 266835019212 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266835019213 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835019214 Walker A/P-loop; other site 266835019215 ATP binding site [chemical binding]; other site 266835019216 Q-loop/lid; other site 266835019217 ABC transporter signature motif; other site 266835019218 Walker B; other site 266835019219 D-loop; other site 266835019220 H-loop/switch region; other site 266835019221 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835019222 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835019223 Walker A/P-loop; other site 266835019224 ATP binding site [chemical binding]; other site 266835019225 Q-loop/lid; other site 266835019226 ABC transporter signature motif; other site 266835019227 Walker B; other site 266835019228 D-loop; other site 266835019229 H-loop/switch region; other site 266835019230 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 266835019231 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266835019232 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266835019233 active site 266835019234 non-prolyl cis peptide bond; other site 266835019235 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 266835019236 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835019237 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266835019238 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835019239 DNA-binding site [nucleotide binding]; DNA binding site 266835019240 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835019241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835019242 homodimer interface [polypeptide binding]; other site 266835019243 catalytic residue [active] 266835019244 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266835019245 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266835019246 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835019247 Helix-turn-helix domains; Region: HTH; cl00088 266835019248 argininosuccinate lyase; Provisional; Region: PRK02186 266835019249 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 266835019250 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 266835019251 active sites [active] 266835019252 tetramer interface [polypeptide binding]; other site 266835019253 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 266835019254 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 266835019255 dimer interface [polypeptide binding]; other site 266835019256 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835019257 catalytic residue [active] 266835019258 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 266835019259 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 266835019260 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 266835019261 Integrase core domain; Region: rve; cl01316 266835019262 Integrase core domain; Region: rve; cl01316 266835019263 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835019264 non-specific DNA binding site [nucleotide binding]; other site 266835019265 salt bridge; other site 266835019266 sequence-specific DNA binding site [nucleotide binding]; other site 266835019267 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 266835019268 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 266835019269 Catalytic site; other site 266835019270 OpgC protein; Region: OpgC_C; cl00792 266835019271 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 266835019272 Helix-turn-helix domains; Region: HTH; cl00088 266835019273 Protein of unknown function (DUF1173); Region: DUF1173; pfam06666 266835019274 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 266835019275 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 266835019276 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266835019277 catalytic residue [active] 266835019278 TrbC/VIRB2 family; Region: TrbC; cl01583 266835019279 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 266835019280 Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451 266835019281 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 266835019282 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 266835019283 VirB8 protein; Region: VirB8; cl01500 266835019284 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 266835019285 VirB7 interaction site; other site 266835019286 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 266835019287 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 266835019288 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 266835019289 Walker A motif; other site 266835019290 hexamer interface [polypeptide binding]; other site 266835019291 ATP binding site [chemical binding]; other site 266835019292 Walker B motif; other site 266835019293 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 266835019294 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 266835019295 Walker A motif; other site 266835019296 ATP binding site [chemical binding]; other site 266835019297 Walker B motif; other site 266835019298 Uncharacterised protein family (UPF0156); Region: RHH_2; cl01448 266835019299 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 266835019300 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 266835019301 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 266835019302 catalytic residues [active] 266835019303 catalytic nucleophile [active] 266835019304 Presynaptic Site I dimer interface [polypeptide binding]; other site 266835019305 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 266835019306 Synaptic Flat tetramer interface [polypeptide binding]; other site 266835019307 Synaptic Site I dimer interface [polypeptide binding]; other site 266835019308 DNA binding site [nucleotide binding] 266835019309 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 266835019310 DNA-binding interface [nucleotide binding]; DNA binding site 266835019311 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266835019312 Helix-turn-helix domains; Region: HTH; cl00088 266835019313 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 266835019314 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835019315 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 266835019316 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 266835019317 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835019318 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266835019319 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835019320 Walker A/P-loop; other site 266835019321 ATP binding site [chemical binding]; other site 266835019322 Q-loop/lid; other site 266835019323 ABC transporter signature motif; other site 266835019324 Walker B; other site 266835019325 D-loop; other site 266835019326 H-loop/switch region; other site 266835019327 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835019328 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 266835019329 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835019330 Walker A/P-loop; other site 266835019331 ATP binding site [chemical binding]; other site 266835019332 Q-loop/lid; other site 266835019333 ABC transporter signature motif; other site 266835019334 Walker B; other site 266835019335 D-loop; other site 266835019336 H-loop/switch region; other site 266835019337 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835019338 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835019339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835019340 dimer interface [polypeptide binding]; other site 266835019341 conserved gate region; other site 266835019342 putative PBP binding loops; other site 266835019343 ABC-ATPase subunit interface; other site 266835019344 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266835019345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835019346 dimer interface [polypeptide binding]; other site 266835019347 conserved gate region; other site 266835019348 putative PBP binding loops; other site 266835019349 ABC-ATPase subunit interface; other site 266835019350 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 266835019351 Sulfatase; Region: Sulfatase; cl10460 266835019352 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266835019353 phosphonate metabolism protein PhnM; Region: phosphono_phnM; TIGR02318 266835019354 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 266835019355 active site 266835019356 Phosphonate metabolism protein PhnG; Region: PhnG; cl01454 266835019357 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; cl01455 266835019358 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; cl01456 266835019359 Phosphonate metabolism protein PhnJ; Region: PhnJ; cl01457 266835019360 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 266835019361 Walker A/P-loop; other site 266835019362 ATP binding site [chemical binding]; other site 266835019363 ABC transporter; Region: ABC_tran; pfam00005 266835019364 Q-loop/lid; other site 266835019365 ABC transporter signature motif; other site 266835019366 Walker B; other site 266835019367 D-loop; other site 266835019368 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835019369 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 266835019370 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 266835019371 Walker A/P-loop; other site 266835019372 ATP binding site [chemical binding]; other site 266835019373 Q-loop/lid; other site 266835019374 ABC transporter signature motif; other site 266835019375 Walker B; other site 266835019376 D-loop; other site 266835019377 H-loop/switch region; other site 266835019378 Protein of unknown function (DUF1045); Region: DUF1045; cl15435 266835019379 Guanylate kinase; Region: Guanylate_kin; pfam00625 266835019380 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835019381 active site 266835019382 Integrase core domain; Region: rve; cl01316 266835019383 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835019384 binding surface 266835019385 TPR motif; other site 266835019386 TPR repeat; Region: TPR_11; pfam13414 266835019387 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835019388 binding surface 266835019389 TPR motif; other site 266835019390 TPR repeat; Region: TPR_11; pfam13414 266835019391 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584 266835019392 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 266835019393 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 266835019394 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266835019395 P-loop; other site 266835019396 Magnesium ion binding site [ion binding]; other site 266835019397 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 266835019398 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 266835019399 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 266835019400 Protein of unknown function (DUF736); Region: DUF736; cl02303 266835019401 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 266835019402 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 266835019403 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 266835019404 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 266835019405 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 266835019406 plasmid partitioning protein; Provisional; Region: PRK13832 266835019407 ParB-like nuclease domain; Region: ParBc; cl02129 266835019408 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; cl11561 266835019409 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835019410 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 266835019411 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 266835019412 Int/Topo IB signature motif; other site 266835019413 INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187 266835019414 Phage integrase family; Region: Phage_integrase; pfam00589 266835019415 Int/Topo IB signature motif; other site 266835019416 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 266835019417 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 266835019418 Int/Topo IB signature motif; other site 266835019419 Putative transposase; Region: Y2_Tnp; pfam04986 266835019420 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 266835019421 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 266835019422 Int/Topo IB signature motif; other site 266835019423 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 266835019424 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 266835019425 Int/Topo IB signature motif; other site 266835019426 INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187 266835019427 Phage integrase family; Region: Phage_integrase; pfam00589 266835019428 Int/Topo IB signature motif; other site 266835019429 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 266835019430 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 266835019431 Int/Topo IB signature motif; other site 266835019432 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835019433 S-adenosylmethionine binding site [chemical binding]; other site 266835019434 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835019435 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 266835019436 Protein of unknown function (DUF1419); Region: DUF1419; pfam07215 266835019437 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 266835019438 active site 266835019439 metal binding site [ion binding]; metal-binding site 266835019440 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 266835019441 oligomerisation interface [polypeptide binding]; other site 266835019442 mobile loop; other site 266835019443 roof hairpin; other site 266835019444 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 266835019445 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 266835019446 ring oligomerisation interface [polypeptide binding]; other site 266835019447 ATP/Mg binding site [chemical binding]; other site 266835019448 stacking interactions; other site 266835019449 hinge regions; other site 266835019450 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 266835019451 Protein of unknown function (DUF1403); Region: DUF1403; pfam07183 266835019452 Protein of unknown function (DUF1403); Region: DUF1403; pfam07183 266835019453 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 266835019454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835019455 Walker A motif; other site 266835019456 ATP binding site [chemical binding]; other site 266835019457 Walker B motif; other site 266835019458 arginine finger; other site 266835019459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835019460 replication initiation protein RepC; Provisional; Region: PRK13824 266835019461 Helix-turn-helix domains; Region: HTH; cl00088 266835019462 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 266835019463 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 266835019464 ParB-like nuclease domain; Region: ParBc; cl02129 266835019465 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 266835019466 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 266835019467 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266835019468 P-loop; other site 266835019469 Magnesium ion binding site [ion binding]; other site 266835019470 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266835019471 Magnesium ion binding site [ion binding]; other site 266835019472 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 266835019473 DNA binding site [nucleotide binding] 266835019474 dimer interface [polypeptide binding]; other site 266835019475 Int/Topo IB signature motif; other site 266835019476 active site 266835019477 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 266835019478 putative active site [active] 266835019479 Rv0623-like transcription factor; Region: PSK_trans_fac; cl01834 266835019480 Protein of unknown function (DUF1403); Region: DUF1403; pfam07183 266835019481 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 266835019482 TniQ; Region: TniQ; pfam06527 266835019483 Integrase core domain; Region: rve; cl01316 266835019484 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 266835019485 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 266835019486 HTH DNA binding domain; Region: HTH_13; pfam11972 266835019487 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835019488 ATP binding site [chemical binding]; other site 266835019489 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 266835019490 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 266835019491 active site 266835019492 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266835019493 dimer interface [polypeptide binding]; other site 266835019494 substrate binding site [chemical binding]; other site 266835019495 catalytic residues [active] 266835019496 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266835019497 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266835019498 active site pocket [active] 266835019499 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 266835019500 active site 266835019501 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 266835019502 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835019503 non-specific DNA binding site [nucleotide binding]; other site 266835019504 salt bridge; other site 266835019505 sequence-specific DNA binding site [nucleotide binding]; other site 266835019506 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 266835019507 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 266835019508 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266835019509 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266835019510 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266835019511 active site 266835019512 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 266835019513 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 266835019514 active site 266835019515 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835019516 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835019517 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835019518 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835019519 Walker A/P-loop; other site 266835019520 ATP binding site [chemical binding]; other site 266835019521 Q-loop/lid; other site 266835019522 ABC transporter signature motif; other site 266835019523 Walker B; other site 266835019524 D-loop; other site 266835019525 H-loop/switch region; other site 266835019526 TOBE domain; Region: TOBE_2; cl01440 266835019527 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835019528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835019529 dimer interface [polypeptide binding]; other site 266835019530 conserved gate region; other site 266835019531 putative PBP binding loops; other site 266835019532 ABC-ATPase subunit interface; other site 266835019533 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835019534 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835019535 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 266835019536 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 266835019537 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835019538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835019539 dimer interface [polypeptide binding]; other site 266835019540 conserved gate region; other site 266835019541 putative PBP binding loops; other site 266835019542 ABC-ATPase subunit interface; other site 266835019543 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424 266835019544 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835019545 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266835019546 Walker A motif; other site 266835019547 ATP binding site [chemical binding]; other site 266835019548 Walker B motif; other site 266835019549 arginine finger; other site 266835019550 Helix-turn-helix domains; Region: HTH; cl00088 266835019551 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835019552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835019553 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 266835019554 Cupin domain; Region: Cupin_2; cl09118 266835019555 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424 266835019556 Uncharacterised protein family (UPF0261); Region: UPF0261; cl02262 266835019557 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424 266835019558 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 266835019559 hypothetical protein; Validated; Region: PRK08238 266835019560 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 266835019561 UbiA prenyltransferase family; Region: UbiA; cl00337 266835019562 Transposase domain (DUF772); Region: DUF772; cl15789 266835019563 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 266835019564 Response regulator receiver domain; Region: Response_reg; pfam00072 266835019565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835019566 active site 266835019567 phosphorylation site [posttranslational modification] 266835019568 intermolecular recognition site; other site 266835019569 dimerization interface [polypeptide binding]; other site 266835019570 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835019571 metal binding site [ion binding]; metal-binding site 266835019572 active site 266835019573 I-site; other site 266835019574 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 266835019575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835019576 active site 266835019577 phosphorylation site [posttranslational modification] 266835019578 intermolecular recognition site; other site 266835019579 CheB methylesterase; Region: CheB_methylest; pfam01339 266835019580 putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916 266835019581 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 266835019582 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 266835019583 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 266835019584 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 266835019585 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 266835019586 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835019587 binding surface 266835019588 TPR motif; other site 266835019589 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 266835019590 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 266835019591 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266835019592 dimerization interface [polypeptide binding]; other site 266835019593 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266835019594 dimer interface [polypeptide binding]; other site 266835019595 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 266835019596 putative CheW interface [polypeptide binding]; other site 266835019597 Predicted membrane protein [Function unknown]; Region: COG2860 266835019598 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 266835019599 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 266835019600 active site 266835019601 DNA binding site [nucleotide binding] 266835019602 The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424 266835019603 DNA binding site [nucleotide binding] 266835019604 Protein of unknown function (DUF768); Region: DUF768; pfam05589 266835019605 Protein of unknown function (DUF768); Region: DUF768; pfam05589 266835019606 Protein of unknown function (DUF768); Region: DUF768; pfam05589 266835019607 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 266835019608 Int/Topo IB signature motif; other site 266835019609 DNA binding site [nucleotide binding] 266835019610 active site 266835019611 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835019612 Helix-turn-helix domains; Region: HTH; cl00088 266835019613 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 266835019614 dimer interface [polypeptide binding]; other site 266835019615 TPP-binding site [chemical binding]; other site 266835019616 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 266835019617 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 266835019618 dimer interface [polypeptide binding]; other site 266835019619 PYR/PP interface [polypeptide binding]; other site 266835019620 TPP binding site [chemical binding]; other site 266835019621 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 266835019622 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 266835019623 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 266835019624 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835019625 catalytic residue [active] 266835019626 dimer interface [polypeptide binding]; other site 266835019627 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 266835019628 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 266835019629 homodimer interface [polypeptide binding]; other site 266835019630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835019631 catalytic residue [active] 266835019632 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 266835019633 Autoinducer binding domain; Region: Autoind_bind; pfam03472 266835019634 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835019635 DNA binding residues [nucleotide binding] 266835019636 dimerization interface [polypeptide binding]; other site 266835019637 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 266835019638 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 266835019639 Domain of unknown function (DUF427); Region: DUF427; cl00998 266835019640 CsbD-like; Region: CsbD; cl01888 266835019641 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 266835019642 active site 266835019643 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 266835019644 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 266835019645 catalytic residues [active] 266835019646 catalytic nucleophile [active] 266835019647 Recombinase; Region: Recombinase; pfam07508 266835019648 RepB plasmid partitioning protein; Region: RepB; pfam07506 266835019649 Protein of unknown function (DUF768); Region: DUF768; pfam05589 266835019650 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 266835019651 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 266835019652 ATP-dependent DNA ligase [DNA replication, recombination, and repair]; Region: CDC9; COG1793 266835019653 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 266835019654 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 266835019655 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 266835019656 DNA-binding site [nucleotide binding]; DNA binding site 266835019657 RNA-binding motif; other site 266835019658 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 266835019659 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 266835019660 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 266835019661 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 266835019662 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 266835019663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 266835019664 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 266835019665 Protein required for attachment to host cells; Region: Host_attach; cl02398 266835019666 Protein of unknown function (DUF982); Region: DUF982; pfam06169 266835019667 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 266835019668 PAS fold; Region: PAS_3; pfam08447 266835019669 putative active site [active] 266835019670 heme pocket [chemical binding]; other site 266835019671 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266835019672 Histidine kinase; Region: HisKA_2; cl06527 266835019673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835019674 active site 266835019675 phosphorylation site [posttranslational modification] 266835019676 intermolecular recognition site; other site 266835019677 dimerization interface [polypeptide binding]; other site 266835019678 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 266835019679 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266835019680 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 266835019681 homotetramer interface [polypeptide binding]; other site 266835019682 Transposase domain (DUF772); Region: DUF772; cl15789 266835019683 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 266835019684 PAS domain; Region: PAS_9; pfam13426 266835019685 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 266835019686 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266835019687 Histidine kinase; Region: HisKA_2; cl06527 266835019688 Protein of unknown function (DUF768); Region: DUF768; pfam05589 266835019689 Protein of unknown function (DUF2274); Region: DUF2274; cl02406 266835019690 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 266835019691 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 266835019692 VirB7 interaction site; other site 266835019693 VirB8 protein; Region: VirB8; cl01500 266835019694 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 266835019695 conjugal transfer protein TrbL; Provisional; Region: PRK13875 266835019696 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314; cl02193 266835019697 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 266835019698 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 266835019699 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835019700 Walker B; other site 266835019701 D-loop; other site 266835019702 H-loop/switch region; other site 266835019703 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 266835019704 TrbC/VIRB2 family; Region: TrbC; cl01583 266835019705 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 266835019706 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835019707 Walker A motif; other site 266835019708 ATP binding site [chemical binding]; other site 266835019709 Walker B motif; other site 266835019710 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266835019711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835019712 dimer interface [polypeptide binding]; other site 266835019713 conserved gate region; other site 266835019714 putative PBP binding loops; other site 266835019715 ABC-ATPase subunit interface; other site 266835019716 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266835019717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835019718 dimer interface [polypeptide binding]; other site 266835019719 conserved gate region; other site 266835019720 putative PBP binding loops; other site 266835019721 ABC-ATPase subunit interface; other site 266835019722 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266835019723 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 266835019724 Walker A/P-loop; other site 266835019725 ATP binding site [chemical binding]; other site 266835019726 Q-loop/lid; other site 266835019727 ABC transporter signature motif; other site 266835019728 Walker B; other site 266835019729 D-loop; other site 266835019730 H-loop/switch region; other site 266835019731 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835019732 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835019733 DNA binding site [nucleotide binding] 266835019734 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 266835019735 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835019736 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 266835019737 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 266835019738 putative DNA binding site [nucleotide binding]; other site 266835019739 putative homodimer interface [polypeptide binding]; other site 266835019740 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 266835019741 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 266835019742 putative DNA binding site [nucleotide binding]; other site 266835019743 putative homodimer interface [polypeptide binding]; other site 266835019744 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 266835019745 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 266835019746 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 266835019747 active site 266835019748 DNA binding site [nucleotide binding] 266835019749 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 266835019750 DNA binding site [nucleotide binding] 266835019751 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 266835019752 nucleotide binding site [chemical binding]; other site 266835019753 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266835019754 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 266835019755 putative dimer interface [polypeptide binding]; other site 266835019756 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 266835019757 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 266835019758 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 266835019759 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 266835019760 D-pathway; other site 266835019761 Putative ubiquinol binding site [chemical binding]; other site 266835019762 Low-spin heme (heme b) binding site [chemical binding]; other site 266835019763 Putative water exit pathway; other site 266835019764 Binuclear center (heme o3/CuB) [ion binding]; other site 266835019765 K-pathway; other site 266835019766 Putative proton exit pathway; other site 266835019767 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 266835019768 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 266835019769 Cytochrome c; Region: Cytochrom_C; cl11414 266835019770 Cytochrome c; Region: Cytochrom_C; cl11414 266835019771 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 266835019772 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 266835019773 putative molybdopterin cofactor binding site [chemical binding]; other site 266835019774 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 266835019775 putative molybdopterin cofactor binding site; other site 266835019776 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 266835019777 SpoVR family protein; Provisional; Region: PRK11767 266835019778 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 266835019779 Uncharacterized conserved protein [Function unknown]; Region: COG2718 266835019780 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 266835019781 PrkA family serine protein kinase; Provisional; Region: PRK15455 266835019782 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835019783 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 266835019784 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 266835019785 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 266835019786 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 266835019787 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 266835019788 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 266835019789 Ca2+ binding site [ion binding]; other site 266835019790 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 266835019791 Protein of unknown function (DUF1403); Region: DUF1403; pfam07183 266835019792 Protein of unknown function (DUF3620); Region: DUF3620; cl02233 266835019793 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 266835019794 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 266835019795 DNA binding site [nucleotide binding] 266835019796 dimer interface [polypeptide binding]; other site 266835019797 Int/Topo IB signature motif; other site 266835019798 active site 266835019799 RES domain; Region: RES; cl02411 266835019800 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 266835019801 replication initiation protein RepC; Provisional; Region: PRK13824 266835019802 Replication protein C N-terminal domain; Region: RP-C; pfam03428 266835019803 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 266835019804 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 266835019805 ParB-like nuclease domain; Region: ParBc; cl02129 266835019806 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 266835019807 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 266835019808 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266835019809 P-loop; other site 266835019810 Magnesium ion binding site [ion binding]; other site 266835019811 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266835019812 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 266835019813 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835019814 putative active site [active] 266835019815 heme pocket [chemical binding]; other site 266835019816 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 266835019817 PAS domain S-box; Region: sensory_box; TIGR00229 266835019818 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835019819 putative active site [active] 266835019820 heme pocket [chemical binding]; other site 266835019821 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266835019822 Histidine kinase; Region: HisKA_2; cl06527 266835019823 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 266835019824 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 266835019825 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 266835019826 dimerization interface [polypeptide binding]; other site 266835019827 metal binding site [ion binding]; metal-binding site 266835019828 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266835019829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835019830 active site 266835019831 phosphorylation site [posttranslational modification] 266835019832 intermolecular recognition site; other site 266835019833 dimerization interface [polypeptide binding]; other site 266835019834 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835019835 DNA binding residues [nucleotide binding] 266835019836 dimerization interface [polypeptide binding]; other site 266835019837 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 266835019838 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 266835019839 Low affinity iron permease; Region: Iron_permease; cl12096 266835019840 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 266835019841 putative active site [active] 266835019842 catalytic site [active] 266835019843 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 266835019844 putative active site [active] 266835019845 catalytic site [active] 266835019846 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266835019847 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 266835019848 putative active site [active] 266835019849 putative metal binding site [ion binding]; other site 266835019850 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266835019851 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 266835019852 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 266835019853 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 266835019854 active site 266835019855 RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467 266835019856 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 266835019857 Walker A motif; other site 266835019858 ATP binding site [chemical binding]; other site 266835019859 Walker B motif; other site 266835019860 DNA repair and recombination protein RadB; Provisional; Region: radB; PRK09361 266835019861 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 266835019862 Walker A motif; other site 266835019863 ATP binding site [chemical binding]; other site 266835019864 Walker B motif; other site 266835019865 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 266835019866 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266835019867 Histidine kinase; Region: HisKA_2; cl06527 266835019868 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 266835019869 PAS domain; Region: PAS_9; pfam13426 266835019870 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266835019871 Histidine kinase; Region: HisKA_2; cl06527 266835019872 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835019873 ATP binding site [chemical binding]; other site 266835019874 Mg2+ binding site [ion binding]; other site 266835019875 G-X-G motif; other site 266835019876 Protein required for attachment to host cells; Region: Host_attach; cl02398 266835019877 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 266835019878 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 266835019879 active site 266835019880 DNA binding site [nucleotide binding] 266835019881 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 266835019882 DNA binding site [nucleotide binding] 266835019883 Isochorismatase family; Region: Isochorismatase; pfam00857 266835019884 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 266835019885 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 266835019886 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 266835019887 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 266835019888 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 266835019889 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 266835019890 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 266835019891 ParB-like nuclease domain; Region: ParBc; cl02129 266835019892 plasmid partitioning protein; Provisional; Region: PRK13832 266835019893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835019894 S-adenosylmethionine binding site [chemical binding]; other site 266835019895 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 266835019896 ATP binding site [chemical binding]; other site 266835019897 putative Mg++ binding site [ion binding]; other site 266835019898 conjugative transfer relaxase protein TraI; Region: TraI_TIGR; TIGR02760 266835019899 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 266835019900 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 266835019901 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 266835019902 active site 266835019903 DNA polymerase IV; Validated; Region: PRK02406 266835019904 DNA binding site [nucleotide binding] 266835019905 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 266835019906 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 266835019907 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 266835019908 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 266835019909 CGNR zinc finger; Region: zf-CGNR; pfam11706 266835019910 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 266835019911 EamA-like transporter family; Region: EamA; cl01037 266835019912 EamA-like transporter family; Region: EamA; cl01037 266835019913 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 266835019914 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 266835019915 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 266835019916 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835019917 active site 266835019918 catalytic tetrad [active] 266835019919 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266835019920 AMP-binding enzyme; Region: AMP-binding; cl15778 266835019921 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 266835019922 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835019923 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 266835019924 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266835019925 active site 266835019926 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 266835019927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835019928 S-adenosylmethionine binding site [chemical binding]; other site 266835019929 Protein of unknown function (DUF768); Region: DUF768; pfam05589 266835019930 Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246 266835019931 Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246 266835019932 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 266835019933 Protein of unknown function (DUF736); Region: DUF736; cl02303 266835019934 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 266835019935 Replication initiator protein A; Region: RPA; cl02339 266835019936 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 266835019937 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 266835019938 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 266835019939 Protein of unknown function (DUF736); Region: DUF736; cl02303 266835019940 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 266835019941 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266835019942 catalytic residue [active] 266835019943 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584 266835019944 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 266835019945 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 266835019946 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 266835019947 Walker A motif; other site 266835019948 ATP binding site [chemical binding]; other site 266835019949 Walker B motif; other site 266835019950 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 266835019951 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 266835019952 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835019953 substrate binding pocket [chemical binding]; other site 266835019954 membrane-bound complex binding site; other site 266835019955 hinge residues; other site 266835019956 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 266835019957 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 266835019958 Protein of unknown function (DUF1515); Region: DUF1515; pfam07439