-- dump date 20120504_152538 -- class Genbank::misc_feature -- table misc_feature_note -- id note 271065000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 271065000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 271065000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065000004 Walker A motif; other site 271065000005 ATP binding site [chemical binding]; other site 271065000006 Walker B motif; other site 271065000007 arginine finger; other site 271065000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 271065000009 DnaA box-binding interface [nucleotide binding]; other site 271065000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 271065000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 271065000012 putative DNA binding surface [nucleotide binding]; other site 271065000013 dimer interface [polypeptide binding]; other site 271065000014 beta-clamp/clamp loader binding surface; other site 271065000015 beta-clamp/translesion DNA polymerase binding surface; other site 271065000016 recombination protein F; Reviewed; Region: recF; PRK00064 271065000017 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065000018 Walker A/P-loop; other site 271065000019 ATP binding site [chemical binding]; other site 271065000020 Q-loop/lid; other site 271065000021 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065000022 ABC transporter signature motif; other site 271065000023 Walker B; other site 271065000024 D-loop; other site 271065000025 H-loop/switch region; other site 271065000026 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 271065000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065000028 Mg2+ binding site [ion binding]; other site 271065000029 G-X-G motif; other site 271065000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 271065000031 anchoring element; other site 271065000032 dimer interface [polypeptide binding]; other site 271065000033 ATP binding site [chemical binding]; other site 271065000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 271065000035 active site 271065000036 putative metal-binding site [ion binding]; other site 271065000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 271065000038 Protein of unknown function (DUF2283); Region: DUF2283; cl02251 271065000039 Outer membrane efflux protein; Region: OEP; pfam02321 271065000040 Outer membrane efflux protein; Region: OEP; pfam02321 271065000041 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271065000042 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 271065000043 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271065000044 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 271065000045 Nitrogen regulatory protein P-II; Region: P-II; cl00412 271065000046 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065000047 PAS fold; Region: PAS_3; pfam08447 271065000048 putative active site [active] 271065000049 heme pocket [chemical binding]; other site 271065000050 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065000051 PAS domain; Region: PAS_9; pfam13426 271065000052 putative active site [active] 271065000053 heme pocket [chemical binding]; other site 271065000054 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065000055 metal binding site [ion binding]; metal-binding site 271065000056 active site 271065000057 I-site; other site 271065000058 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065000059 Winged helix-turn helix; Region: HTH_29; pfam13551 271065000060 Helix-turn-helix domains; Region: HTH; cl00088 271065000061 Integrase core domain; Region: rve; cl01316 271065000062 Integrase core domain; Region: rve_3; cl15866 271065000063 rod shape-determining protein MreC; Provisional; Region: PRK13922 271065000064 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 271065000065 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 271065000066 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 271065000067 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 271065000068 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 271065000069 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 271065000070 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 271065000071 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 271065000072 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 271065000073 dimerization interface [polypeptide binding]; other site 271065000074 active site 271065000075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 271065000076 SEC-C motif; Region: SEC-C; pfam02810 271065000077 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 271065000078 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 271065000079 ligand binding site [chemical binding]; other site 271065000080 flexible hinge region; other site 271065000081 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 271065000082 putative switch regulator; other site 271065000083 non-specific DNA interactions [nucleotide binding]; other site 271065000084 DNA binding site [nucleotide binding] 271065000085 sequence specific DNA binding site [nucleotide binding]; other site 271065000086 putative cAMP binding site [chemical binding]; other site 271065000087 OsmC-like protein; Region: OsmC; cl00767 271065000088 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 271065000089 Sel1 repeat; Region: Sel1; cl02723 271065000090 Sel1 repeat; Region: Sel1; cl02723 271065000091 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 271065000092 linker region; other site 271065000093 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 271065000094 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 271065000095 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 271065000096 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271065000097 ligand binding site [chemical binding]; other site 271065000098 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 271065000099 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 271065000100 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 271065000101 substrate pocket [chemical binding]; other site 271065000102 active site 271065000103 dimer interface [polypeptide binding]; other site 271065000104 proteolytic cleavage site; other site 271065000105 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271065000106 transcriptional regulator NarL; Provisional; Region: PRK10651 271065000107 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 271065000108 Cation efflux family; Region: Cation_efflux; cl00316 271065000109 alpha-glucosidase; Provisional; Region: PRK10137 271065000110 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 271065000111 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 271065000112 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 271065000113 ligand binding site [chemical binding]; other site 271065000114 flexible hinge region; other site 271065000115 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 271065000116 putative switch regulator; other site 271065000117 non-specific DNA interactions [nucleotide binding]; other site 271065000118 DNA binding site [nucleotide binding] 271065000119 sequence specific DNA binding site [nucleotide binding]; other site 271065000120 putative cAMP binding site [chemical binding]; other site 271065000121 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 271065000122 cyclase homology domain; Region: CHD; cd07302 271065000123 nucleotidyl binding site; other site 271065000124 metal binding site [ion binding]; metal-binding site 271065000125 dimer interface [polypeptide binding]; other site 271065000126 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 271065000127 Catalytic domain of Protein Kinases; Region: PKc; cd00180 271065000128 active site 271065000129 ATP binding site [chemical binding]; other site 271065000130 substrate binding site [chemical binding]; other site 271065000131 activation loop (A-loop); other site 271065000132 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 271065000133 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 271065000134 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 271065000135 active site 271065000136 ATP binding site [chemical binding]; other site 271065000137 substrate binding site [chemical binding]; other site 271065000138 activation loop (A-loop); other site 271065000139 Predicted ATPase [General function prediction only]; Region: COG3899 271065000140 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065000141 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 271065000142 GAF domain; Region: GAF; cl15785 271065000143 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 271065000144 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065000145 dimer interface [polypeptide binding]; other site 271065000146 phosphorylation site [posttranslational modification] 271065000147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065000148 ATP binding site [chemical binding]; other site 271065000149 Mg2+ binding site [ion binding]; other site 271065000150 G-X-G motif; other site 271065000151 Response regulator receiver domain; Region: Response_reg; pfam00072 271065000152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065000153 active site 271065000154 phosphorylation site [posttranslational modification] 271065000155 intermolecular recognition site; other site 271065000156 dimerization interface [polypeptide binding]; other site 271065000157 Response regulator receiver domain; Region: Response_reg; pfam00072 271065000158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065000159 active site 271065000160 phosphorylation site [posttranslational modification] 271065000161 intermolecular recognition site; other site 271065000162 dimerization interface [polypeptide binding]; other site 271065000163 PAS fold; Region: PAS; pfam00989 271065000164 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065000165 putative active site [active] 271065000166 heme pocket [chemical binding]; other site 271065000167 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065000168 metal binding site [ion binding]; metal-binding site 271065000169 active site 271065000170 I-site; other site 271065000171 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065000172 CAAX protease self-immunity; Region: Abi; cl00558 271065000173 YcgL domain; Region: YcgL; cl01189 271065000174 MatE; Region: MatE; cl10513 271065000175 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 271065000176 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 271065000177 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 271065000178 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065000179 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271065000180 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 271065000181 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 271065000182 active site 271065000183 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 271065000184 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 271065000185 active site 271065000186 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271065000187 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 271065000188 putative ADP-binding pocket [chemical binding]; other site 271065000189 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 271065000190 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 271065000191 putative NAD(P) binding site [chemical binding]; other site 271065000192 active site 271065000193 putative substrate binding site [chemical binding]; other site 271065000194 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 271065000195 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 271065000196 Mg++ binding site [ion binding]; other site 271065000197 putative catalytic motif [active] 271065000198 putative substrate binding site [chemical binding]; other site 271065000199 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 271065000200 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 271065000201 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 271065000202 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065000203 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 271065000204 NAD(P) binding site [chemical binding]; other site 271065000205 homodimer interface [polypeptide binding]; other site 271065000206 substrate binding site [chemical binding]; other site 271065000207 active site 271065000208 transcriptional regulator; Provisional; Region: PRK10632 271065000209 Helix-turn-helix domains; Region: HTH; cl00088 271065000210 NPR1/NIM1 like defence protein C terminal; Region: NPR1_like_C; pfam12313 271065000211 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271065000212 putative effector binding pocket; other site 271065000213 dimerization interface [polypeptide binding]; other site 271065000214 tellurite resistance protein TehB; Provisional; Region: PRK12335 271065000215 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 271065000216 active site residue [active] 271065000217 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 271065000218 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 271065000219 G1 box; other site 271065000220 putative GEF interaction site [polypeptide binding]; other site 271065000221 GTP/Mg2+ binding site [chemical binding]; other site 271065000222 Switch I region; other site 271065000223 G2 box; other site 271065000224 G3 box; other site 271065000225 Switch II region; other site 271065000226 G4 box; other site 271065000227 G5 box; other site 271065000228 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 271065000229 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 271065000230 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 271065000231 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 271065000232 putative active site pocket [active] 271065000233 4-fold oligomerization interface [polypeptide binding]; other site 271065000234 metal binding residues [ion binding]; metal-binding site 271065000235 3-fold/trimer interface [polypeptide binding]; other site 271065000236 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 271065000237 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 271065000238 putative active site [active] 271065000239 oxyanion strand; other site 271065000240 catalytic triad [active] 271065000241 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 271065000242 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 271065000243 catalytic residues [active] 271065000244 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 271065000245 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 271065000246 substrate binding site [chemical binding]; other site 271065000247 glutamase interaction surface [polypeptide binding]; other site 271065000248 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 271065000249 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 271065000250 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 271065000251 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 271065000252 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 271065000253 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 271065000254 active site 271065000255 catalytic triad [active] 271065000256 oxyanion hole [active] 271065000257 switch loop; other site 271065000258 pteridine reductase; Provisional; Region: PRK09135 271065000259 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 271065000260 NADP binding site [chemical binding]; other site 271065000261 substrate binding pocket [chemical binding]; other site 271065000262 active site 271065000263 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 271065000264 active site 271065000265 ATP binding site [chemical binding]; other site 271065000266 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 271065000267 catalytic center binding site [active] 271065000268 ATP binding site [chemical binding]; other site 271065000269 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 271065000270 active site 271065000271 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 271065000272 UGMP family protein; Validated; Region: PRK09604 271065000273 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 271065000274 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 271065000275 GatB domain; Region: GatB_Yqey; cl11497 271065000276 DNA primase; Validated; Region: dnaG; PRK05667 271065000277 CHC2 zinc finger; Region: zf-CHC2; cl15369 271065000278 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 271065000279 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 271065000280 active site 271065000281 metal binding site [ion binding]; metal-binding site 271065000282 interdomain interaction site; other site 271065000283 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 271065000284 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 271065000285 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 271065000286 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 271065000287 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 271065000288 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 271065000289 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271065000290 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 271065000291 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 271065000292 DNA binding residues [nucleotide binding] 271065000293 S-adenosylmethionine synthetase; Validated; Region: PRK05250 271065000294 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 271065000295 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 271065000296 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 271065000297 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 271065000298 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401 271065000299 oligomerization interface [polypeptide binding]; other site 271065000300 active site 271065000301 NAD+ binding site [chemical binding]; other site 271065000302 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 271065000303 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 271065000304 FAD binding site [chemical binding]; other site 271065000305 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 271065000306 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 271065000307 CAAX protease self-immunity; Region: Abi; cl00558 271065000308 Protein of unknown function (DUF520); Region: DUF520; cl00723 271065000309 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 271065000310 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 271065000311 active site 271065000312 NTP binding site [chemical binding]; other site 271065000313 metal binding triad [ion binding]; metal-binding site 271065000314 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 271065000315 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 271065000316 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 271065000317 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 271065000318 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 271065000319 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 271065000320 active site 271065000321 GMP synthase; Reviewed; Region: guaA; PRK00074 271065000322 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 271065000323 AMP/PPi binding site [chemical binding]; other site 271065000324 candidate oxyanion hole; other site 271065000325 catalytic triad [active] 271065000326 potential glutamine specificity residues [chemical binding]; other site 271065000327 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 271065000328 ATP Binding subdomain [chemical binding]; other site 271065000329 Ligand Binding sites [chemical binding]; other site 271065000330 Dimerization subdomain; other site 271065000331 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 271065000332 nucleoside/Zn binding site; other site 271065000333 dimer interface [polypeptide binding]; other site 271065000334 catalytic motif [active] 271065000335 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 271065000336 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 271065000337 active site 271065000338 dimer interface [polypeptide binding]; other site 271065000339 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 271065000340 dimer interface [polypeptide binding]; other site 271065000341 active site 271065000342 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271065000343 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 271065000344 YceI-like domain; Region: YceI; cl01001 271065000345 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 271065000346 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 271065000347 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 271065000348 Walker A/P-loop; other site 271065000349 ATP binding site [chemical binding]; other site 271065000350 Q-loop/lid; other site 271065000351 ABC transporter signature motif; other site 271065000352 Walker B; other site 271065000353 D-loop; other site 271065000354 H-loop/switch region; other site 271065000355 Permease; Region: Permease; cl00510 271065000356 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 271065000357 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 271065000358 Walker A/P-loop; other site 271065000359 ATP binding site [chemical binding]; other site 271065000360 Q-loop/lid; other site 271065000361 ABC transporter signature motif; other site 271065000362 Walker B; other site 271065000363 D-loop; other site 271065000364 H-loop/switch region; other site 271065000365 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 271065000366 mce related protein; Region: MCE; pfam02470 271065000367 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 271065000368 Cu(I) binding site [ion binding]; other site 271065000369 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 271065000370 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 271065000371 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 271065000372 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271065000373 Helix-turn-helix domains; Region: HTH; cl00088 271065000374 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 271065000375 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 271065000376 catalytic residue [active] 271065000377 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 271065000378 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 271065000379 Walker A motif; other site 271065000380 ATP binding site [chemical binding]; other site 271065000381 Walker B motif; other site 271065000382 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 271065000383 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065000384 ATP binding site [chemical binding]; other site 271065000385 Walker B motif; other site 271065000386 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 271065000387 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 271065000388 putative metal binding site [ion binding]; other site 271065000389 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 271065000390 HSP70 interaction site [polypeptide binding]; other site 271065000391 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 271065000392 ATP binding site [chemical binding]; other site 271065000393 active site 271065000394 substrate binding site [chemical binding]; other site 271065000395 hypothetical protein; Reviewed; Region: PRK00024 271065000396 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 271065000397 MPN+ (JAMM) motif; other site 271065000398 Zinc-binding site [ion binding]; other site 271065000399 phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase, prokaryotic; Region: coaBC_dfp; TIGR00521 271065000400 Flavoprotein; Region: Flavoprotein; cl08021 271065000401 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 271065000402 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 271065000403 trimer interface [polypeptide binding]; other site 271065000404 active site 271065000405 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 271065000406 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 271065000407 active site 271065000408 substrate binding site [chemical binding]; other site 271065000409 metal binding site [ion binding]; metal-binding site 271065000410 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 271065000411 feedback inhibition sensing region; other site 271065000412 homohexameric interface [polypeptide binding]; other site 271065000413 nucleotide binding site [chemical binding]; other site 271065000414 N-acetyl-L-glutamate binding site [chemical binding]; other site 271065000415 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 271065000416 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 271065000417 YGGT family; Region: YGGT; cl00508 271065000418 YGGT family; Region: YGGT; cl00508 271065000419 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 271065000420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065000421 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 271065000422 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 271065000423 classical (c) SDRs; Region: SDR_c; cd05233 271065000424 NAD(P) binding site [chemical binding]; other site 271065000425 active site 271065000426 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 271065000427 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065000428 primosome assembly protein PriA; Validated; Region: PRK05580 271065000429 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271065000430 ATP binding site [chemical binding]; other site 271065000431 putative Mg++ binding site [ion binding]; other site 271065000432 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065000433 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 271065000434 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 271065000435 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 271065000436 active site 271065000437 HIGH motif; other site 271065000438 nucleotide binding site [chemical binding]; other site 271065000439 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 271065000440 KMSK motif region; other site 271065000441 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 271065000442 tRNA binding surface [nucleotide binding]; other site 271065000443 anticodon binding site; other site 271065000444 Sporulation related domain; Region: SPOR; cl10051 271065000445 Evidence 7 : Gene remnant 271065000446 Evidence 7 : Gene remnant 271065000447 Evidence 7 : Gene remnant 271065000448 Evidence 7 : Gene remnant 271065000449 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 271065000450 active site 271065000451 ribulose/triose binding site [chemical binding]; other site 271065000452 phosphate binding site [ion binding]; other site 271065000453 substrate (anthranilate) binding pocket [chemical binding]; other site 271065000454 product (indole) binding pocket [chemical binding]; other site 271065000455 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 271065000456 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 271065000457 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 271065000458 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 271065000459 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 271065000460 glutamine binding [chemical binding]; other site 271065000461 catalytic triad [active] 271065000462 anthranilate synthase component I; Provisional; Region: PRK13565 271065000463 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 271065000464 chorismate binding enzyme; Region: Chorismate_bind; cl10555 271065000465 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 271065000466 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 271065000467 sensor protein QseC; Provisional; Region: PRK10337 271065000468 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 271065000469 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065000470 dimer interface [polypeptide binding]; other site 271065000471 phosphorylation site [posttranslational modification] 271065000472 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065000473 ATP binding site [chemical binding]; other site 271065000474 Mg2+ binding site [ion binding]; other site 271065000475 G-X-G motif; other site 271065000476 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 271065000477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065000478 active site 271065000479 phosphorylation site [posttranslational modification] 271065000480 intermolecular recognition site; other site 271065000481 dimerization interface [polypeptide binding]; other site 271065000482 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271065000483 DNA binding site [nucleotide binding] 271065000484 HemN family oxidoreductase; Provisional; Region: PRK05660 271065000485 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271065000486 FeS/SAM binding site; other site 271065000487 HemN C-terminal domain; Region: HemN_C; pfam06969 271065000488 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 271065000489 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 271065000490 active site 271065000491 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065000492 Dynamin family; Region: Dynamin_N; pfam00350 271065000493 G1 box; other site 271065000494 GTP/Mg2+ binding site [chemical binding]; other site 271065000495 G2 box; other site 271065000496 Switch I region; other site 271065000497 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 271065000498 G3 box; other site 271065000499 Switch II region; other site 271065000500 GTP/Mg2+ binding site [chemical binding]; other site 271065000501 G4 box; other site 271065000502 G5 box; other site 271065000503 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 271065000504 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 271065000505 bifunctional sulfur carrier protein/thiazole synthase protein; Provisional; Region: PRK11840 271065000506 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 271065000507 thiS-thiF/thiG interaction site; other site 271065000508 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 271065000509 ThiS interaction site; other site 271065000510 putative active site [active] 271065000511 tetramer interface [polypeptide binding]; other site 271065000512 NeuB family; Region: NeuB; cl00496 271065000513 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 271065000514 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 271065000515 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 271065000516 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065000517 Walker A/P-loop; other site 271065000518 ATP binding site [chemical binding]; other site 271065000519 Q-loop/lid; other site 271065000520 ABC transporter signature motif; other site 271065000521 Walker B; other site 271065000522 D-loop; other site 271065000523 H-loop/switch region; other site 271065000524 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 271065000525 Domain of unknown function (DUF389); Region: DUF389; cl00781 271065000526 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 271065000527 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 271065000528 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 271065000529 Transposase; Region: DEDD_Tnp_IS110; pfam01548 271065000530 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 271065000531 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 271065000532 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 271065000533 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 271065000534 metal-binding site [ion binding] 271065000535 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 271065000536 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271065000537 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 271065000538 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 271065000539 putative acyl-acceptor binding pocket; other site 271065000540 Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538 271065000541 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 271065000542 Evidence 6 : Doubtful CDS 271065000543 Right handed beta helix region; Region: Beta_helix; pfam13229 271065000544 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 96094287, 99328963, 99448397; Product type t : transporter 271065000545 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 96094287, 99328963, 99448397; Product type t : transporter 271065000546 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 271065000547 potential frameshift: common BLAST hit: gi|333982446|ref|YP_004511656.1| family 2 glycosyl transferase 271065000548 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 271065000549 bacteriophage N4 adsorption protein B; Provisional; Region: PRK14716 271065000550 Glycosyl hydrolases family 17; Region: Glyco_hydro_17; cl02191 271065000551 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 271065000552 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 271065000553 active site 271065000554 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271065000555 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271065000556 active site 271065000557 DNA binding site [nucleotide binding] 271065000558 Int/Topo IB signature motif; other site 271065000559 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 271065000560 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 271065000561 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 271065000562 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 271065000563 Transposase; Region: DDE_Tnp_ISL3; pfam01610 271065000564 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 271065000565 Integrase core domain; Region: rve; cl01316 271065000566 transposase; Provisional; Region: PRK06526 271065000567 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065000568 Walker A motif; other site 271065000569 ATP binding site [chemical binding]; other site 271065000570 Walker B motif; other site 271065000571 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin 271065000572 Evidence 4 : Homologs of previously reported genes of unknown function 271065000573 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 271065000574 Antitoxin ParD; Region: ParD; pfam09386 271065000575 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 271065000576 catalytic residues [active] 271065000577 catalytic nucleophile [active] 271065000578 Presynaptic Site I dimer interface [polypeptide binding]; other site 271065000579 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 271065000580 Synaptic Flat tetramer interface [polypeptide binding]; other site 271065000581 Synaptic Site I dimer interface [polypeptide binding]; other site 271065000582 DNA binding site [nucleotide binding] 271065000583 DNA helicase IV; Provisional; Region: helD; PRK11054 271065000584 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 271065000585 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065000586 DNA helicase IV; Provisional; Region: helD; PRK11054 271065000587 Family description; Region: UvrD_C_2; cl15862 271065000588 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 271065000589 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 271065000590 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 271065000591 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271065000592 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 271065000593 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 271065000594 catalytic motif [active] 271065000595 Catalytic residue [active] 271065000596 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 271065000597 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 271065000598 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 271065000599 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 271065000600 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 271065000601 molybdopterin cofactor binding site; other site 271065000602 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 271065000603 molybdopterin cofactor binding site; other site 271065000604 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271065000605 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 271065000606 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 271065000607 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 271065000608 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 271065000609 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 271065000610 HlyD family secretion protein; Region: HlyD_2; pfam12700 271065000611 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271065000612 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 271065000613 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 271065000614 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271065000615 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 271065000616 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065000617 Walker A/P-loop; other site 271065000618 ATP binding site [chemical binding]; other site 271065000619 ABC transporter; Region: ABC_tran; pfam00005 271065000620 Q-loop/lid; other site 271065000621 ABC transporter signature motif; other site 271065000622 Walker B; other site 271065000623 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 271065000624 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 271065000625 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 271065000626 Walker A motif; other site 271065000627 ATP binding site [chemical binding]; other site 271065000628 Walker B motif; other site 271065000629 Uncharacterized conserved protein [Function unknown]; Region: COG3391 271065000630 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 271065000631 dimer interface [polypeptide binding]; other site 271065000632 substrate binding site [chemical binding]; other site 271065000633 metal binding sites [ion binding]; metal-binding site 271065000634 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 271065000635 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 271065000636 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 271065000637 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 271065000638 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 271065000639 active site 271065000640 Zn binding site [ion binding]; other site 271065000641 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 271065000642 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 271065000643 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 271065000644 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 271065000645 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 271065000646 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 271065000647 dimer interface [polypeptide binding]; other site 271065000648 active site residues [active] 271065000649 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 271065000650 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 271065000651 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12682 271065000652 Helix-turn-helix domains; Region: HTH; cl00088 271065000653 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 271065000654 substrate binding site [chemical binding]; other site 271065000655 dimerization interface [polypeptide binding]; other site 271065000656 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 271065000657 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271065000658 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 271065000659 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 271065000660 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296 271065000661 Walker A/P-loop; other site 271065000662 ATP binding site [chemical binding]; other site 271065000663 Q-loop/lid; other site 271065000664 ABC transporter signature motif; other site 271065000665 Walker B; other site 271065000666 D-loop; other site 271065000667 H-loop/switch region; other site 271065000668 sulfate transport protein; Provisional; Region: cysT; CHL00187 271065000669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271065000670 dimer interface [polypeptide binding]; other site 271065000671 conserved gate region; other site 271065000672 putative PBP binding loops; other site 271065000673 ABC-ATPase subunit interface; other site 271065000674 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 271065000675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271065000676 dimer interface [polypeptide binding]; other site 271065000677 conserved gate region; other site 271065000678 putative PBP binding loops; other site 271065000679 ABC-ATPase subunit interface; other site 271065000680 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271065000681 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 271065000682 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 271065000683 Uncharacterized small protein (DUF2292); Region: DUF2292; cl02371 271065000684 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 271065000685 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 271065000686 active site 271065000687 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 271065000688 AMP-binding enzyme; Region: AMP-binding; cl15778 271065000689 AMP-binding enzyme; Region: AMP-binding; cl15778 271065000690 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271065000691 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 271065000692 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065000693 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 271065000694 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 271065000695 dimer interface [polypeptide binding]; other site 271065000696 active site 271065000697 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 271065000698 putative active site 1 [active] 271065000699 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 271065000700 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 271065000701 NAD(P) binding site [chemical binding]; other site 271065000702 homotetramer interface [polypeptide binding]; other site 271065000703 homodimer interface [polypeptide binding]; other site 271065000704 active site 271065000705 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 271065000706 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 271065000707 dimer interface [polypeptide binding]; other site 271065000708 active site 271065000709 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 271065000710 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 271065000711 putative substrate binding site [chemical binding]; other site 271065000712 putative ATP binding site [chemical binding]; other site 271065000713 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 271065000714 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 271065000715 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065000716 metal binding site [ion binding]; metal-binding site 271065000717 active site 271065000718 I-site; other site 271065000719 Protein of unknown function DUF72; Region: DUF72; cl00777 271065000720 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 271065000721 hypothetical protein; Reviewed; Region: PRK09588 271065000722 Archease protein family (MTH1598/TM1083); Region: Archease; cl00606 271065000723 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 271065000724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065000725 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 271065000726 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 271065000727 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 271065000728 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 271065000729 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 271065000730 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 271065000731 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271065000732 substrate binding pocket [chemical binding]; other site 271065000733 membrane-bound complex binding site; other site 271065000734 hinge residues; other site 271065000735 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 271065000736 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 271065000737 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 271065000738 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 271065000739 iron binding site [ion binding]; other site 271065000740 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 271065000741 Domain of unknown function (DUF336); Region: DUF336; cl01249 271065000742 fumarate hydratase; Reviewed; Region: fumC; PRK00485 271065000743 Class II fumarases; Region: Fumarase_classII; cd01362 271065000744 active site 271065000745 tetramer interface [polypeptide binding]; other site 271065000746 Ferritin-like domain; Region: Ferritin; pfam00210 271065000747 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 271065000748 dinuclear metal binding motif [ion binding]; other site 271065000749 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 271065000750 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 271065000751 active site 271065000752 substrate binding site [chemical binding]; other site 271065000753 Mg2+ binding site [ion binding]; other site 271065000754 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 271065000755 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 271065000756 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate family; Region: PorB_KorB; TIGR02177 271065000757 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 271065000758 TPP-binding site [chemical binding]; other site 271065000759 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 271065000760 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 271065000761 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 271065000762 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 271065000763 dimer interface [polypeptide binding]; other site 271065000764 PYR/PP interface [polypeptide binding]; other site 271065000765 TPP binding site [chemical binding]; other site 271065000766 substrate binding site [chemical binding]; other site 271065000767 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 271065000768 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 271065000769 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 271065000770 Domain of unknown function (DUF4326); Region: DUF4326; pfam14216 271065000771 Protein of unknown function (DUF2283); Region: DUF2283; cl02251 271065000772 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271065000773 non-specific DNA binding site [nucleotide binding]; other site 271065000774 salt bridge; other site 271065000775 sequence-specific DNA binding site [nucleotide binding]; other site 271065000776 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 271065000777 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 271065000778 TSCPD domain; Region: TSCPD; cl14834 271065000779 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 271065000780 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 271065000781 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 271065000782 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 271065000783 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 271065000784 Homing endonuclease; Region: Hom_end; pfam05204 271065000785 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 271065000786 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 271065000787 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 271065000788 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 271065000789 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271065000790 ATP binding site [chemical binding]; other site 271065000791 putative Mg++ binding site [ion binding]; other site 271065000792 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271065000793 nucleotide binding region [chemical binding]; other site 271065000794 ATP-binding site [chemical binding]; other site 271065000795 Double zinc ribbon; Region: DZR; pfam12773 271065000796 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 271065000797 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 271065000798 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 271065000799 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 271065000800 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065000801 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 271065000802 Membrane fusogenic activity; Region: BMFP; cl01115 271065000803 Helix-turn-helix domains; Region: HTH; cl00088 271065000804 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cl02586 271065000805 aconitate hydratase; Validated; Region: PRK09277 271065000806 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 271065000807 substrate binding site [chemical binding]; other site 271065000808 ligand binding site [chemical binding]; other site 271065000809 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 271065000810 substrate binding site [chemical binding]; other site 271065000811 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 271065000812 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 271065000813 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271065000814 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 271065000815 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 271065000816 CreA protein; Region: CreA; pfam05981 271065000817 Predicted transcriptional regulator [Transcription]; Region: COG2345 271065000818 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 271065000819 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065000820 Walker A motif; other site 271065000821 ATP binding site [chemical binding]; other site 271065000822 Walker B motif; other site 271065000823 arginine finger; other site 271065000824 Helix-turn-helix domains; Region: HTH; cl00088 271065000825 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 271065000826 active site clefts [active] 271065000827 zinc binding site [ion binding]; other site 271065000828 dimer interface [polypeptide binding]; other site 271065000829 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271065000830 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271065000831 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 271065000832 Coenzyme A binding pocket [chemical binding]; other site 271065000833 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 271065000834 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 271065000835 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 271065000836 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 271065000837 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 271065000838 MoxR-like ATPases [General function prediction only]; Region: COG0714 271065000839 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065000840 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 271065000841 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 271065000842 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065000843 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065000844 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 271065000845 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065000846 S-adenosylmethionine binding site [chemical binding]; other site 271065000847 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 271065000848 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 271065000849 P-loop; other site 271065000850 Magnesium ion binding site [ion binding]; other site 271065000851 ParB-like partition proteins; Region: parB_part; TIGR00180 271065000852 ParB-like nuclease domain; Region: ParBc; cl02129 271065000853 ATP synthase I chain; Region: ATP_synt_I; cl09170 271065000854 ATP synthase A chain; Region: ATP-synt_A; cl00413 271065000855 ATP synthase subunit C; Region: ATP-synt_C; cl00466 271065000856 Plant ATP synthase F0; Region: YMF19; cl07975 271065000857 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 271065000858 Plant ATP synthase F0; Region: YMF19; cl07975 271065000859 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 271065000860 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 271065000861 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 271065000862 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 271065000863 beta subunit interaction interface [polypeptide binding]; other site 271065000864 Walker A motif; other site 271065000865 ATP binding site [chemical binding]; other site 271065000866 Walker B motif; other site 271065000867 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 271065000868 ATP synthase; Region: ATP-synt; cl00365 271065000869 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 271065000870 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 271065000871 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 271065000872 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 271065000873 alpha subunit interaction interface [polypeptide binding]; other site 271065000874 Walker A motif; other site 271065000875 ATP binding site [chemical binding]; other site 271065000876 Walker B motif; other site 271065000877 inhibitor binding site; inhibition site 271065000878 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 271065000879 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 271065000880 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 271065000881 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 271065000882 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 271065000883 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 271065000884 Substrate binding site; other site 271065000885 Mg++ binding site; other site 271065000886 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 271065000887 active site 271065000888 substrate binding site [chemical binding]; other site 271065000889 CoA binding site [chemical binding]; other site 271065000890 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 271065000891 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 271065000892 glutaminase active site [active] 271065000893 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 271065000894 dimer interface [polypeptide binding]; other site 271065000895 active site 271065000896 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 271065000897 dimer interface [polypeptide binding]; other site 271065000898 active site 271065000899 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 271065000900 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 271065000901 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 271065000902 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 271065000903 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 271065000904 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 271065000905 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 271065000906 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 271065000907 Uncharacterized conserved protein [Function unknown]; Region: COG3391 271065000908 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 271065000909 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 271065000910 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 271065000911 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 271065000912 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 271065000913 active site residue [active] 271065000914 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271065000915 Helix-turn-helix domains; Region: HTH; cl00088 271065000916 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 271065000917 Cytochrome C'; Region: Cytochrom_C_2; cl01610 271065000918 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 271065000919 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 271065000920 Walker A/P-loop; other site 271065000921 ATP binding site [chemical binding]; other site 271065000922 Q-loop/lid; other site 271065000923 ABC transporter signature motif; other site 271065000924 Walker B; other site 271065000925 D-loop; other site 271065000926 H-loop/switch region; other site 271065000927 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 271065000928 FtsX-like permease family; Region: FtsX; cl15850 271065000929 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 271065000930 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271065000931 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271065000932 division inhibitor protein; Provisional; Region: slmA; PRK09480 271065000933 Helix-turn-helix domains; Region: HTH; cl00088 271065000934 NlpE N-terminal domain; Region: NlpE; cl01138 271065000935 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 271065000936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065000937 S-adenosylmethionine binding site [chemical binding]; other site 271065000938 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 271065000939 Isochorismatase family; Region: Isochorismatase; pfam00857 271065000940 catalytic triad [active] 271065000941 metal binding site [ion binding]; metal-binding site 271065000942 conserved cis-peptide bond; other site 271065000943 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 271065000944 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 271065000945 active site 271065000946 Protein of unknown function (DUF2452); Region: DUF2452; pfam10504 271065000947 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 271065000948 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271065000949 ATP binding site [chemical binding]; other site 271065000950 putative Mg++ binding site [ion binding]; other site 271065000951 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271065000952 nucleotide binding region [chemical binding]; other site 271065000953 ATP-binding site [chemical binding]; other site 271065000954 DEAD/H associated; Region: DEAD_assoc; pfam08494 271065000955 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 271065000956 Smr domain; Region: Smr; cl02619 271065000957 Domain of unknown function (DUF697); Region: DUF697; cl12064 271065000958 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 271065000959 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 271065000960 ATP binding site [chemical binding]; other site 271065000961 Mg++ binding site [ion binding]; other site 271065000962 motif III; other site 271065000963 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271065000964 nucleotide binding region [chemical binding]; other site 271065000965 ATP-binding site [chemical binding]; other site 271065000966 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 271065000967 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 271065000968 catalytic site [active] 271065000969 G-X2-G-X-G-K; other site 271065000970 Phosphotransferase enzyme family; Region: APH; pfam01636 271065000971 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 271065000972 active site 271065000973 substrate binding site [chemical binding]; other site 271065000974 ATP binding site [chemical binding]; other site 271065000975 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 271065000976 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065000977 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 271065000978 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065000979 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 271065000980 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 271065000981 DNA photolyase; Region: DNA_photolyase; pfam00875 271065000982 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 271065000983 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 271065000984 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 271065000985 putative hydrophobic ligand binding site [chemical binding]; other site 271065000986 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 271065000987 Protein of unknown function (DUF523); Region: DUF523; cl00733 271065000988 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 271065000989 EamA-like transporter family; Region: EamA; cl01037 271065000990 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 271065000991 EamA-like transporter family; Region: EamA; cl01037 271065000992 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 271065000993 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 271065000994 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065000995 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 271065000996 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065000997 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 271065000998 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 271065000999 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 271065001000 synthetase active site [active] 271065001001 NTP binding site [chemical binding]; other site 271065001002 metal binding site [ion binding]; metal-binding site 271065001003 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 271065001004 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 271065001005 DNA polymerase I; Provisional; Region: PRK05755 271065001006 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 271065001007 active site 271065001008 metal binding site 1 [ion binding]; metal-binding site 271065001009 putative 5' ssDNA interaction site; other site 271065001010 metal binding site 3; metal-binding site 271065001011 metal binding site 2 [ion binding]; metal-binding site 271065001012 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 271065001013 putative DNA binding site [nucleotide binding]; other site 271065001014 putative metal binding site [ion binding]; other site 271065001015 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 271065001016 active site 271065001017 catalytic site [active] 271065001018 substrate binding site [chemical binding]; other site 271065001019 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 271065001020 active site 271065001021 DNA binding site [nucleotide binding] 271065001022 catalytic site [active] 271065001023 HDOD domain; Region: HDOD; pfam08668 271065001024 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 271065001025 Zn2+ binding site [ion binding]; other site 271065001026 Mg2+ binding site [ion binding]; other site 271065001027 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 271065001028 Predicted GTPase [General function prediction only]; Region: COG0218 271065001029 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 271065001030 G1 box; other site 271065001031 GTP/Mg2+ binding site [chemical binding]; other site 271065001032 Switch I region; other site 271065001033 G2 box; other site 271065001034 G3 box; other site 271065001035 Switch II region; other site 271065001036 G4 box; other site 271065001037 G5 box; other site 271065001038 Cytochrome c; Region: Cytochrom_C; cl11414 271065001039 Cytochrome c; Region: Cytochrom_C; cl11414 271065001040 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 271065001041 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 271065001042 catalytic residues [active] 271065001043 hinge region; other site 271065001044 alpha helical domain; other site 271065001045 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065001046 metal binding site [ion binding]; metal-binding site 271065001047 active site 271065001048 I-site; other site 271065001049 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 271065001050 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 271065001051 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 271065001052 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 271065001053 generic binding surface II; other site 271065001054 generic binding surface I; other site 271065001055 Flagellar regulator YcgR; Region: YcgR; pfam07317 271065001056 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 271065001057 PilZ domain; Region: PilZ; cl01260 271065001058 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 271065001059 DsrE/DsrF-like family; Region: DrsE; cl00672 271065001060 DsrC like protein; Region: DsrC; cl01101 271065001061 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 271065001062 RNA binding surface [nucleotide binding]; other site 271065001063 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 271065001064 active site residue [active] 271065001065 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065001066 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 271065001067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065001068 LytB protein; Region: LYTB; cl00507 271065001069 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 271065001070 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 271065001071 putative protease; Provisional; Region: PRK15452 271065001072 Peptidase family U32; Region: Peptidase_U32; cl03113 271065001073 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 271065001074 putative active site [active] 271065001075 dimerization interface [polypeptide binding]; other site 271065001076 putative tRNAtyr binding site [nucleotide binding]; other site 271065001077 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 271065001078 Staphylococcal nuclease homologues; Region: SNc; smart00318 271065001079 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 271065001080 Catalytic site; other site 271065001081 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 271065001082 Protein of unknown function (DUF692); Region: DUF692; cl01263 271065001083 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 271065001084 endonuclease III; Provisional; Region: PRK10702 271065001085 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 271065001086 minor groove reading motif; other site 271065001087 helix-hairpin-helix signature motif; other site 271065001088 substrate binding pocket [chemical binding]; other site 271065001089 active site 271065001090 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 271065001091 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 271065001092 FMN-binding domain; Region: FMN_bind; cl01081 271065001093 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 271065001094 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 271065001095 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 271065001096 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 271065001097 SLBB domain; Region: SLBB; pfam10531 271065001098 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 271065001099 electron transport complex protein RnfB; Provisional; Region: PRK05113 271065001100 Putative Fe-S cluster; Region: FeS; pfam04060 271065001101 4Fe-4S binding domain; Region: Fer4; cl02805 271065001102 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 271065001103 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 271065001104 Sulfate transporter family; Region: Sulfate_transp; cl15842 271065001105 Sulfate transporter family; Region: Sulfate_transp; cl15842 271065001106 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 271065001107 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 271065001108 active site clefts [active] 271065001109 zinc binding site [ion binding]; other site 271065001110 dimer interface [polypeptide binding]; other site 271065001111 GDP-mannose 4,6-dehydratase; Region: gmd; TIGR01472 271065001112 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 271065001113 NADP-binding site; other site 271065001114 homotetramer interface [polypeptide binding]; other site 271065001115 substrate binding site [chemical binding]; other site 271065001116 homodimer interface [polypeptide binding]; other site 271065001117 active site 271065001118 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 271065001119 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 271065001120 NADP binding site [chemical binding]; other site 271065001121 active site 271065001122 putative substrate binding site [chemical binding]; other site 271065001123 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 271065001124 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 271065001125 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065001126 nucleotide binding region [chemical binding]; other site 271065001127 ATP-binding site [chemical binding]; other site 271065001128 hypothetical protein; Provisional; Region: PRK10396 271065001129 SEC-C motif; Region: SEC-C; pfam02810 271065001130 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 271065001131 homodimer interface [polypeptide binding]; other site 271065001132 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 271065001133 active site pocket [active] 271065001134 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 271065001135 Transposase domain (DUF772); Region: DUF772; cl15789 271065001136 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 271065001137 Transposase domain (DUF772); Region: DUF772; cl15789 271065001138 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 271065001139 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065001140 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 271065001141 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 271065001142 SecA binding site; other site 271065001143 Preprotein binding site; other site 271065001144 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 271065001145 active site residue [active] 271065001146 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271065001147 dimerization interface [polypeptide binding]; other site 271065001148 putative DNA binding site [nucleotide binding]; other site 271065001149 putative Zn2+ binding site [ion binding]; other site 271065001150 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 271065001151 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 271065001152 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 271065001153 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 271065001154 protein binding site [polypeptide binding]; other site 271065001155 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 271065001156 Catalytic dyad [active] 271065001157 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 271065001158 NodB motif; other site 271065001159 putative active site [active] 271065001160 putative catalytic site [active] 271065001161 Zn binding site [ion binding]; other site 271065001162 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 271065001163 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271065001164 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271065001165 PAS domain; Region: PAS_9; pfam13426 271065001166 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065001167 PAS fold; Region: PAS_3; pfam08447 271065001168 putative active site [active] 271065001169 heme pocket [chemical binding]; other site 271065001170 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065001171 dimer interface [polypeptide binding]; other site 271065001172 phosphorylation site [posttranslational modification] 271065001173 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065001174 ATP binding site [chemical binding]; other site 271065001175 Mg2+ binding site [ion binding]; other site 271065001176 G-X-G motif; other site 271065001177 Response regulator receiver domain; Region: Response_reg; pfam00072 271065001178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 271065001179 active site 271065001180 phosphorylation site [posttranslational modification] 271065001181 intermolecular recognition site; other site 271065001182 dimerization interface [polypeptide binding]; other site 271065001183 Response regulator receiver domain; Region: Response_reg; pfam00072 271065001184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065001185 active site 271065001186 phosphorylation site [posttranslational modification] 271065001187 intermolecular recognition site; other site 271065001188 dimerization interface [polypeptide binding]; other site 271065001189 Response regulator receiver domain; Region: Response_reg; pfam00072 271065001190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065001191 active site 271065001192 phosphorylation site [posttranslational modification] 271065001193 intermolecular recognition site; other site 271065001194 dimerization interface [polypeptide binding]; other site 271065001195 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065001196 metal binding site [ion binding]; metal-binding site 271065001197 active site 271065001198 I-site; other site 271065001199 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 271065001200 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065001201 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 271065001202 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 271065001203 Protein of unknown function (DUF2956); Region: DUF2956; pfam11169 271065001204 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271065001205 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271065001206 Uncharacterized conserved protein [Function unknown]; Region: COG3391 271065001207 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 271065001208 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 271065001209 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 271065001210 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 271065001211 active site 271065001212 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 271065001213 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065001214 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 271065001215 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 271065001216 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271065001217 substrate binding site [chemical binding]; other site 271065001218 oxyanion hole (OAH) forming residues; other site 271065001219 trimer interface [polypeptide binding]; other site 271065001220 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 271065001221 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 271065001222 dimer interface [polypeptide binding]; other site 271065001223 active site 271065001224 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271065001225 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 271065001226 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 271065001227 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065001228 Walker A motif; other site 271065001229 ATP binding site [chemical binding]; other site 271065001230 Walker B motif; other site 271065001231 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 271065001232 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 271065001233 Ligand Binding Site [chemical binding]; other site 271065001234 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 271065001235 CPxP motif; other site 271065001236 Cation efflux family; Region: Cation_efflux; cl00316 271065001237 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 271065001238 heterotetramer interface [polypeptide binding]; other site 271065001239 active site pocket [active] 271065001240 cleavage site 271065001241 hypothetical protein; Provisional; Region: PRK08999 271065001242 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 271065001243 active site 271065001244 8-oxo-dGMP binding site [chemical binding]; other site 271065001245 nudix motif; other site 271065001246 metal binding site [ion binding]; metal-binding site 271065001247 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 271065001248 thiamine phosphate binding site [chemical binding]; other site 271065001249 active site 271065001250 pyrophosphate binding site [ion binding]; other site 271065001251 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 271065001252 catalytic residues [active] 271065001253 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 271065001254 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 271065001255 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 271065001256 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 271065001257 PilZ domain; Region: PilZ; cl01260 271065001258 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 271065001259 general secretory pathway protein E; Region: type_II_gspE; TIGR02533 271065001260 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065001261 Walker A motif; other site 271065001262 ATP binding site [chemical binding]; other site 271065001263 Walker B motif; other site 271065001264 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 271065001265 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 271065001266 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 271065001267 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 271065001268 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 271065001269 Protein of unknown function (DUF3438); Region: DUF3438; cl13372 271065001270 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 271065001271 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 271065001272 putative active site [active] 271065001273 putative catalytic triad [active] 271065001274 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 271065001275 catalytic residues [active] 271065001276 Transposase IS200 like; Region: Y1_Tnp; cl00848 271065001277 MoxR-like ATPases [General function prediction only]; Region: COG0714 271065001278 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065001279 Walker A motif; other site 271065001280 ATP binding site [chemical binding]; other site 271065001281 Walker B motif; other site 271065001282 arginine finger; other site 271065001283 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 271065001284 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 271065001285 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 271065001286 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 271065001287 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 271065001288 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 271065001289 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 271065001290 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 271065001291 active site 271065001292 catalytic tetrad [active] 271065001293 Macrophage migration inhibitory factor (MIF); Region: MIF; pfam01187 271065001294 Nitrogen regulatory protein P-II; Region: P-II; smart00938 271065001295 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 271065001296 putative cation:proton antiport protein; Provisional; Region: PRK10669 271065001297 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 271065001298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065001299 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 271065001300 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 271065001301 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 271065001302 Preprotein translocase subunit; Region: YajC; cl00806 271065001303 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 271065001304 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 271065001305 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 271065001306 Protein export membrane protein; Region: SecD_SecF; cl14618 271065001307 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 271065001308 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 271065001309 Protein export membrane protein; Region: SecD_SecF; cl14618 271065001310 Winged helix-turn helix; Region: HTH_29; pfam13551 271065001311 Helix-turn-helix domains; Region: HTH; cl00088 271065001312 Integrase core domain; Region: rve; cl01316 271065001313 Integrase core domain; Region: rve_3; cl15866 271065001314 Helix-turn-helix domains; Region: HTH; cl00088 271065001315 rod shape-determining protein MreC; Provisional; Region: PRK13922 271065001316 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 271065001317 active site 271065001318 multimer interface [polypeptide binding]; other site 271065001319 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 271065001320 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271065001321 FeS/SAM binding site; other site 271065001322 TPR repeat; Region: TPR_11; pfam13414 271065001323 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271065001324 binding surface 271065001325 TPR motif; other site 271065001326 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 271065001327 binding surface 271065001328 TPR motif; other site 271065001329 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 271065001330 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 271065001331 dimer interface [polypeptide binding]; other site 271065001332 motif 1; other site 271065001333 active site 271065001334 motif 2; other site 271065001335 motif 3; other site 271065001336 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 271065001337 anticodon binding site; other site 271065001338 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 271065001339 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 271065001340 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 271065001341 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 271065001342 Trp docking motif [polypeptide binding]; other site 271065001343 active site 271065001344 GTP-binding protein Der; Reviewed; Region: PRK00093 271065001345 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 271065001346 G1 box; other site 271065001347 GTP/Mg2+ binding site [chemical binding]; other site 271065001348 Switch I region; other site 271065001349 G2 box; other site 271065001350 Switch II region; other site 271065001351 G3 box; other site 271065001352 G4 box; other site 271065001353 G5 box; other site 271065001354 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 271065001355 G1 box; other site 271065001356 GTP/Mg2+ binding site [chemical binding]; other site 271065001357 Switch I region; other site 271065001358 G2 box; other site 271065001359 G3 box; other site 271065001360 Switch II region; other site 271065001361 G4 box; other site 271065001362 G5 box; other site 271065001363 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 271065001364 heme-binding site [chemical binding]; other site 271065001365 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 271065001366 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065001367 putative active site [active] 271065001368 heme pocket [chemical binding]; other site 271065001369 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065001370 dimer interface [polypeptide binding]; other site 271065001371 phosphorylation site [posttranslational modification] 271065001372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065001373 ATP binding site [chemical binding]; other site 271065001374 Mg2+ binding site [ion binding]; other site 271065001375 G-X-G motif; other site 271065001376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065001377 Response regulator receiver domain; Region: Response_reg; pfam00072 271065001378 active site 271065001379 phosphorylation site [posttranslational modification] 271065001380 intermolecular recognition site; other site 271065001381 dimerization interface [polypeptide binding]; other site 271065001382 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 271065001383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065001384 active site 271065001385 phosphorylation site [posttranslational modification] 271065001386 intermolecular recognition site; other site 271065001387 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065001388 metal binding site [ion binding]; metal-binding site 271065001389 active site 271065001390 I-site; other site 271065001391 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065001392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065001393 active site 271065001394 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 271065001395 phosphorylation site [posttranslational modification] 271065001396 intermolecular recognition site; other site 271065001397 dimerization interface [polypeptide binding]; other site 271065001398 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065001399 putative active site [active] 271065001400 heme pocket [chemical binding]; other site 271065001401 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065001402 metal binding site [ion binding]; metal-binding site 271065001403 active site 271065001404 I-site; other site 271065001405 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065001406 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 271065001407 Protein of unknown function, DUF; Region: DUF411; cl01142 271065001408 Ammonia monooxygenase/methane monooxygenase, subunit C; Region: AmoC; cl04829 271065001409 Ammonia monooxygenase; Region: AMO; cl03602 271065001410 methane monooxygenase/ammonia monooxygenase, subunit B; Region: CH4_NH3mon_ox_B; TIGR03079 271065001411 Monooxygenase subunit B protein; Region: Monooxygenase_B; pfam04744 271065001412 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 271065001413 Protein of unknown function, DUF393; Region: DUF393; cl01136 271065001414 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 271065001415 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 271065001416 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 271065001417 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 271065001418 substrate binding pocket [chemical binding]; other site 271065001419 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 271065001420 B12 binding site [chemical binding]; other site 271065001421 cobalt ligand [ion binding]; other site 271065001422 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 271065001423 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 271065001424 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 271065001425 Cupin domain; Region: Cupin_2; cl09118 271065001426 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 271065001427 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 271065001428 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 271065001429 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 271065001430 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 271065001431 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 271065001432 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065001433 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 271065001434 Septum formation initiator; Region: DivIC; cl11433 271065001435 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065001436 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 271065001437 NAD(P) binding site [chemical binding]; other site 271065001438 LDH/MDH dimer interface [polypeptide binding]; other site 271065001439 substrate binding site [chemical binding]; other site 271065001440 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 271065001441 MatE; Region: MatE; cl10513 271065001442 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 271065001443 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 271065001444 Walker A/P-loop; other site 271065001445 ATP binding site [chemical binding]; other site 271065001446 Q-loop/lid; other site 271065001447 ABC transporter signature motif; other site 271065001448 Walker B; other site 271065001449 D-loop; other site 271065001450 H-loop/switch region; other site 271065001451 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 271065001452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271065001453 dimer interface [polypeptide binding]; other site 271065001454 conserved gate region; other site 271065001455 putative PBP binding loops; other site 271065001456 ABC-ATPase subunit interface; other site 271065001457 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 271065001458 membrane-bound complex binding site; other site 271065001459 hinge residues; other site 271065001460 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 271065001461 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271065001462 FeS/SAM binding site; other site 271065001463 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 271065001464 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 271065001465 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 271065001466 ATP binding site [chemical binding]; other site 271065001467 Mg++ binding site [ion binding]; other site 271065001468 motif III; other site 271065001469 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271065001470 nucleotide binding region [chemical binding]; other site 271065001471 ATP-binding site [chemical binding]; other site 271065001472 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 271065001473 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 271065001474 oxaloacetate decarboxylase; Provisional; Region: PRK14040 271065001475 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 271065001476 active site 271065001477 catalytic residues [active] 271065001478 metal binding site [ion binding]; metal-binding site 271065001479 homodimer binding site [polypeptide binding]; other site 271065001480 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 271065001481 carboxyltransferase (CT) interaction site; other site 271065001482 biotinylation site [posttranslational modification]; other site 271065001483 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 271065001484 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 271065001485 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 271065001486 N-terminal plug; other site 271065001487 ligand-binding site [chemical binding]; other site 271065001488 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 271065001489 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 271065001490 HupE / UreJ protein; Region: HupE_UreJ; cl01011 271065001491 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 271065001492 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 271065001493 N-terminal plug; other site 271065001494 ligand-binding site [chemical binding]; other site 271065001495 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 271065001496 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065001497 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 271065001498 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 271065001499 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 271065001500 putative peptidase; Provisional; Region: PRK11649 271065001501 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 271065001502 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 271065001503 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 271065001504 active site 271065001505 HIGH motif; other site 271065001506 dimer interface [polypeptide binding]; other site 271065001507 KMSKS motif; other site 271065001508 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 271065001509 Evidence 7 : Gene remnant; Product type pr : regulator 271065001510 Evidence 7 : Gene remnant; Product type pr : regulator 271065001511 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 271065001512 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065001513 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 271065001514 Walker A motif; other site 271065001515 ATP binding site [chemical binding]; other site 271065001516 Walker B motif; other site 271065001517 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065001518 ABC transporter ATPase component; Reviewed; Region: PRK11147 271065001519 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 271065001520 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 271065001521 ABC transporter; Region: ABC_tran_2; pfam12848 271065001522 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 271065001523 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 271065001524 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 271065001525 putative MPT binding site; other site 271065001526 Membrane transport protein; Region: Mem_trans; cl09117 271065001527 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 271065001528 active site 271065001529 dimer interface [polypeptide binding]; other site 271065001530 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 271065001531 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 271065001532 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065001533 Walker A motif; other site 271065001534 ATP binding site [chemical binding]; other site 271065001535 Walker B motif; other site 271065001536 arginine finger; other site 271065001537 Helix-turn-helix domains; Region: HTH; cl00088 271065001538 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 271065001539 active site 271065001540 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 271065001541 active site 271065001542 hydrophilic channel; other site 271065001543 dimerization interface [polypeptide binding]; other site 271065001544 catalytic residues [active] 271065001545 active site lid [active] 271065001546 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 271065001547 Recombination protein O N terminal; Region: RecO_N; cl15812 271065001548 Recombination protein O C terminal; Region: RecO_C; pfam02565 271065001549 GTPase Era; Reviewed; Region: era; PRK00089 271065001550 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 271065001551 G1 box; other site 271065001552 GTP/Mg2+ binding site [chemical binding]; other site 271065001553 Switch I region; other site 271065001554 G2 box; other site 271065001555 Switch II region; other site 271065001556 G3 box; other site 271065001557 G4 box; other site 271065001558 G5 box; other site 271065001559 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 271065001560 ribonuclease III; Reviewed; Region: rnc; PRK00102 271065001561 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 271065001562 dimerization interface [polypeptide binding]; other site 271065001563 active site 271065001564 metal binding site [ion binding]; metal-binding site 271065001565 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 271065001566 dsRNA binding site [nucleotide binding]; other site 271065001567 signal peptidase I; Provisional; Region: PRK10861 271065001568 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 271065001569 Catalytic site [active] 271065001570 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 271065001571 GTP-binding protein LepA; Provisional; Region: PRK05433 271065001572 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 271065001573 G1 box; other site 271065001574 putative GEF interaction site [polypeptide binding]; other site 271065001575 GTP/Mg2+ binding site [chemical binding]; other site 271065001576 Switch I region; other site 271065001577 G2 box; other site 271065001578 G3 box; other site 271065001579 Switch II region; other site 271065001580 G4 box; other site 271065001581 G5 box; other site 271065001582 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 271065001583 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 271065001584 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 271065001585 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 271065001586 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 271065001587 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 271065001588 protein binding site [polypeptide binding]; other site 271065001589 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 271065001590 protein binding site [polypeptide binding]; other site 271065001591 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 271065001592 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 271065001593 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 271065001594 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 271065001595 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271065001596 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 271065001597 DNA binding residues [nucleotide binding] 271065001598 L-aspartate oxidase; Provisional; Region: PRK09077 271065001599 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065001600 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 271065001601 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065001602 G1 box; other site 271065001603 GTP/Mg2+ binding site [chemical binding]; other site 271065001604 G2 box; other site 271065001605 Switch I region; other site 271065001606 G3 box; other site 271065001607 Switch II region; other site 271065001608 putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073 271065001609 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271065001610 ligand binding site [chemical binding]; other site 271065001611 Cation efflux family; Region: Cation_efflux; cl00316 271065001612 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 271065001613 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 271065001614 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 271065001615 Serine carboxypeptidase S28; Region: Peptidase_S28; cl15279 271065001616 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 271065001617 Flavoprotein; Region: Flavoprotein; cl08021 271065001618 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 271065001619 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 271065001620 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271065001621 FeS/SAM binding site; other site 271065001622 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 271065001623 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 271065001624 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 271065001625 putative active site [active] 271065001626 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 271065001627 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 271065001628 PqqA family; Region: PqqA; cl15372 271065001629 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 271065001630 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 271065001631 quinone interaction residues [chemical binding]; other site 271065001632 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 271065001633 active site 271065001634 catalytic residues [active] 271065001635 FMN binding site [chemical binding]; other site 271065001636 substrate binding site [chemical binding]; other site 271065001637 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 271065001638 EamA-like transporter family; Region: EamA; cl01037 271065001639 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 271065001640 active site 271065001641 substrate binding site [chemical binding]; other site 271065001642 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271065001643 ATP binding site [chemical binding]; other site 271065001644 putative Mg++ binding site [ion binding]; other site 271065001645 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271065001646 nucleotide binding region [chemical binding]; other site 271065001647 ATP-binding site [chemical binding]; other site 271065001648 DNA helicase IV; Provisional; Region: helD; PRK11054 271065001649 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065001650 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 271065001651 Family description; Region: UvrD_C_2; cl15862 271065001652 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 271065001653 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 271065001654 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 271065001655 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 271065001656 Walker A/P-loop; other site 271065001657 ATP binding site [chemical binding]; other site 271065001658 Q-loop/lid; other site 271065001659 ABC transporter signature motif; other site 271065001660 Walker B; other site 271065001661 D-loop; other site 271065001662 H-loop/switch region; other site 271065001663 ABC transporter; Region: ABC_tran_2; pfam12848 271065001664 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 271065001665 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 271065001666 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 271065001667 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 271065001668 putative ADP-binding pocket [chemical binding]; other site 271065001669 sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial; Region: sucr_syn_bact_C; TIGR02471 271065001670 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 271065001671 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 271065001672 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 271065001673 putative substrate binding site [chemical binding]; other site 271065001674 putative ATP binding site [chemical binding]; other site 271065001675 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 271065001676 trehalose synthase; Region: treS_nterm; TIGR02456 271065001677 active site 271065001678 catalytic site [active] 271065001679 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 271065001680 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 271065001681 Walker A/P-loop; other site 271065001682 ATP binding site [chemical binding]; other site 271065001683 Q-loop/lid; other site 271065001684 ABC transporter signature motif; other site 271065001685 Walker B; other site 271065001686 D-loop; other site 271065001687 H-loop/switch region; other site 271065001688 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 271065001689 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 271065001690 PspA/IM30 family; Region: PspA_IM30; pfam04012 271065001691 Ion channel; Region: Ion_trans_2; cl11596 271065001692 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065001693 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 271065001694 Predicted membrane protein [Function unknown]; Region: COG3766 271065001695 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 271065001696 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 271065001697 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 271065001698 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 271065001699 Protein of unknown function (DUF2872); Region: DUF2872; cl11924 271065001700 Domain of unknown function (DUF1820); Region: DUF1820; cl11545 271065001701 Stringent starvation protein B; Region: SspB; cl01120 271065001702 stringent starvation protein A; Provisional; Region: sspA; PRK09481 271065001703 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 271065001704 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 271065001705 dimer interface [polypeptide binding]; other site 271065001706 N-terminal domain interface [polypeptide binding]; other site 271065001707 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 271065001708 cytochrome b; Provisional; Region: CYTB; MTH00145 271065001709 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 271065001710 Qi binding site; other site 271065001711 intrachain domain interface; other site 271065001712 interchain domain interface [polypeptide binding]; other site 271065001713 heme bH binding site [chemical binding]; other site 271065001714 heme bL binding site [chemical binding]; other site 271065001715 Qo binding site; other site 271065001716 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 271065001717 interchain domain interface [polypeptide binding]; other site 271065001718 intrachain domain interface; other site 271065001719 Qi binding site; other site 271065001720 Qo binding site; other site 271065001721 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 271065001722 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 271065001723 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 271065001724 [2Fe-2S] cluster binding site [ion binding]; other site 271065001725 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 271065001726 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271065001727 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271065001728 homodimer interface [polypeptide binding]; other site 271065001729 catalytic residue [active] 271065001730 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 271065001731 histidinol dehydrogenase; Region: hisD; TIGR00069 271065001732 NAD binding site [chemical binding]; other site 271065001733 dimerization interface [polypeptide binding]; other site 271065001734 product binding site; other site 271065001735 substrate binding site [chemical binding]; other site 271065001736 zinc binding site [ion binding]; other site 271065001737 catalytic residues [active] 271065001738 ATP phosphoribosyltransferase; Region: HisG; cl15266 271065001739 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 271065001740 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 271065001741 hinge; other site 271065001742 active site 271065001743 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 271065001744 anti sigma factor interaction site; other site 271065001745 regulatory phosphorylation site [posttranslational modification]; other site 271065001746 mce related protein; Region: MCE; pfam02470 271065001747 Permease; Region: Permease; cl00510 271065001748 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 271065001749 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 271065001750 Walker A/P-loop; other site 271065001751 ATP binding site [chemical binding]; other site 271065001752 Q-loop/lid; other site 271065001753 ABC transporter signature motif; other site 271065001754 Walker B; other site 271065001755 D-loop; other site 271065001756 H-loop/switch region; other site 271065001757 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 271065001758 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 271065001759 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 271065001760 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 271065001761 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 271065001762 putative active site [active] 271065001763 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 271065001764 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 271065001765 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271065001766 active site 271065001767 motif I; other site 271065001768 motif II; other site 271065001769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 271065001770 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 271065001771 OstA-like protein; Region: OstA; cl00844 271065001772 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 271065001773 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 271065001774 Walker A/P-loop; other site 271065001775 ATP binding site [chemical binding]; other site 271065001776 Q-loop/lid; other site 271065001777 ABC transporter signature motif; other site 271065001778 Walker B; other site 271065001779 D-loop; other site 271065001780 H-loop/switch region; other site 271065001781 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 271065001782 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 271065001783 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 271065001784 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 271065001785 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 271065001786 30S subunit binding site; other site 271065001787 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 271065001788 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 271065001789 Protein of unknown function (DUF2582); Region: DUF2582; pfam10771 271065001790 Septum formation topological specificity factor MinE; Region: MinE; cl00538 271065001791 cell division inhibitor MinD; Provisional; Region: PRK10818 271065001792 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 271065001793 Switch I; other site 271065001794 Switch II; other site 271065001795 septum formation inhibitor; Reviewed; Region: minC; PRK00339 271065001796 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 271065001797 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 271065001798 Phosphate transporter family; Region: PHO4; cl00396 271065001799 Phosphate transporter family; Region: PHO4; cl00396 271065001800 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 271065001801 ThiC-associated domain; Region: ThiC-associated; pfam13667 271065001802 ThiC family; Region: ThiC; cl08031 271065001803 Sensors of blue-light using FAD; Region: BLUF; cl04855 271065001804 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 271065001805 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 271065001806 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 271065001807 binding surface 271065001808 TPR motif; other site 271065001809 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 271065001810 metal ion-dependent adhesion site (MIDAS); other site 271065001811 FliW protein; Region: FliW; cl00740 271065001812 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 271065001813 tetramerization interface [polypeptide binding]; other site 271065001814 active site 271065001815 Pantoate-beta-alanine ligase; Region: PanC; cd00560 271065001816 pantoate--beta-alanine ligase; Region: panC; TIGR00018 271065001817 active site 271065001818 ATP-binding site [chemical binding]; other site 271065001819 pantoate-binding site; other site 271065001820 HXXH motif; other site 271065001821 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 271065001822 oligomerization interface [polypeptide binding]; other site 271065001823 active site 271065001824 metal binding site [ion binding]; metal-binding site 271065001825 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 271065001826 catalytic center binding site [active] 271065001827 ATP binding site [chemical binding]; other site 271065001828 poly(A) polymerase; Region: pcnB; TIGR01942 271065001829 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 271065001830 active site 271065001831 NTP binding site [chemical binding]; other site 271065001832 metal binding triad [ion binding]; metal-binding site 271065001833 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 271065001834 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 271065001835 RDD family; Region: RDD; cl00746 271065001836 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 271065001837 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 271065001838 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 271065001839 multifunctional aminopeptidase A; Provisional; Region: PRK00913 271065001840 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 271065001841 interface (dimer of trimers) [polypeptide binding]; other site 271065001842 Substrate-binding/catalytic site; other site 271065001843 Zn-binding sites [ion binding]; other site 271065001844 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 271065001845 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 271065001846 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 271065001847 HIGH motif; other site 271065001848 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 271065001849 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 271065001850 active site 271065001851 KMSKS motif; other site 271065001852 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 271065001853 tRNA binding surface [nucleotide binding]; other site 271065001854 anticodon binding site; other site 271065001855 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 271065001856 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 271065001857 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 271065001858 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 271065001859 Walker A motif; other site 271065001860 ATP binding site [chemical binding]; other site 271065001861 Walker B motif; other site 271065001862 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 271065001863 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 271065001864 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 271065001865 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 271065001866 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 271065001867 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 271065001868 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 271065001869 CoA-binding site [chemical binding]; other site 271065001870 ATP-binding [chemical binding]; other site 271065001871 Protein of unknown function (DUF1342); Region: DUF1342; cl01892 271065001872 Domain of unknown function (DUF329); Region: DUF329; cl01144 271065001873 Daxx Family; Region: Daxx; pfam03344 271065001874 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 271065001875 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 271065001876 ATP binding site [chemical binding]; other site 271065001877 profilin binding site; other site 271065001878 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 271065001879 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 271065001880 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 271065001881 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 271065001882 HSP70 interaction site [polypeptide binding]; other site 271065001883 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 271065001884 Transposase; Region: DDE_Tnp_ISL3; pfam01610 271065001885 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065001886 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 271065001887 PPIC-type PPIASE domain; Region: Rotamase; cl08278 271065001888 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 271065001889 Uncharacterized conserved protein [Function unknown]; Region: COG2308 271065001890 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 271065001891 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 271065001892 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 271065001893 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 271065001894 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 271065001895 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 271065001896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 271065001897 Plant specific mitochondrial import receptor subunit TOM20; Region: TOM20_plant; pfam06552 271065001898 Protein of unknown function (DUF2288); Region: DUF2288; cl02399 271065001899 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 271065001900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271065001901 Major Facilitator Superfamily; Region: MFS_1; pfam07690 271065001902 putative substrate translocation pore; other site 271065001903 Catalytic domain of Protein Kinases; Region: PKc; cd00180 271065001904 Protein kinase domain; Region: Pkinase; pfam00069 271065001905 active site 271065001906 ATP binding site [chemical binding]; other site 271065001907 substrate binding site [chemical binding]; other site 271065001908 activation loop (A-loop); other site 271065001909 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065001910 Predicted ATPase [General function prediction only]; Region: COG3899 271065001911 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 271065001912 GAF domain; Region: GAF; cl15785 271065001913 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065001914 metal binding site [ion binding]; metal-binding site 271065001915 active site 271065001916 I-site; other site 271065001917 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 271065001918 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 271065001919 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 271065001920 glucokinase, proteobacterial type; Region: glk; TIGR00749 271065001921 Late competence development protein ComFB; Region: ComFB; pfam10719 271065001922 Protein of unknown function (DUF721); Region: DUF721; cl02324 271065001923 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 271065001924 dimer interface [polypeptide binding]; other site 271065001925 motif 1; other site 271065001926 active site 271065001927 motif 2; other site 271065001928 motif 3; other site 271065001929 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 271065001930 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 271065001931 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 271065001932 putative acyl-acceptor binding pocket; other site 271065001933 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 271065001934 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 271065001935 putative active site [active] 271065001936 catalytic triad [active] 271065001937 putative dimer interface [polypeptide binding]; other site 271065001938 Helix-turn-helix domains; Region: HTH; cl00088 271065001939 rod shape-determining protein MreC; Provisional; Region: PRK13922 271065001940 Winged helix-turn helix; Region: HTH_29; pfam13551 271065001941 Helix-turn-helix domains; Region: HTH; cl00088 271065001942 Integrase core domain; Region: rve; cl01316 271065001943 Integrase core domain; Region: rve_3; cl15866 271065001944 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 271065001945 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 271065001946 putative ion selectivity filter; other site 271065001947 putative pore gating glutamate residue; other site 271065001948 putative H+/Cl- coupling transport residue; other site 271065001949 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 271065001950 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 271065001951 dimerization interface [polypeptide binding]; other site 271065001952 active site 271065001953 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 271065001954 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 271065001955 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065001956 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 271065001957 putative NAD(P) binding site [chemical binding]; other site 271065001958 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 271065001959 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065001960 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 271065001961 SWIM zinc finger; Region: SWIM; cl15408 271065001962 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 271065001963 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271065001964 ATP binding site [chemical binding]; other site 271065001965 putative Mg++ binding site [ion binding]; other site 271065001966 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271065001967 nucleotide binding region [chemical binding]; other site 271065001968 ATP-binding site [chemical binding]; other site 271065001969 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 271065001970 putative active site [active] 271065001971 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 271065001972 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 271065001973 Beta-Casp domain; Region: Beta-Casp; cl12567 271065001974 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 271065001975 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 271065001976 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 271065001977 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 271065001978 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 271065001979 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 271065001980 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 271065001981 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 271065001982 NAD(P) binding site [chemical binding]; other site 271065001983 homodimer interface [polypeptide binding]; other site 271065001984 substrate binding site [chemical binding]; other site 271065001985 active site 271065001986 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 271065001987 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 271065001988 inhibitor-cofactor binding pocket; inhibition site 271065001989 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271065001990 catalytic residue [active] 271065001991 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 271065001992 ligand binding site; other site 271065001993 tetramer interface; other site 271065001994 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 271065001995 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 271065001996 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 271065001997 active site 271065001998 nucleotide binding site [chemical binding]; other site 271065001999 HIGH motif; other site 271065002000 KMSKS motif; other site 271065002001 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 271065002002 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 271065002003 active site 271065002004 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 271065002005 metal-binding site 271065002006 Methyltransferase domain; Region: Methyltransf_31; pfam13847 271065002007 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 271065002008 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 271065002009 inhibitor-cofactor binding pocket; inhibition site 271065002010 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271065002011 catalytic residue [active] 271065002012 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 271065002013 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 271065002014 putative trimer interface [polypeptide binding]; other site 271065002015 putative CoA binding site [chemical binding]; other site 271065002016 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271065002017 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 271065002018 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 271065002019 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271065002020 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 271065002021 LicD family; Region: LicD; cl01378 271065002022 pseudaminic acid synthase; Region: PseI; TIGR03586 271065002023 NeuB family; Region: NeuB; cl00496 271065002024 SAF domain; Region: SAF; cl00555 271065002025 flagellin; Provisional; Region: PRK12802 271065002026 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 271065002027 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 271065002028 FlaG protein; Region: FlaG; cl00591 271065002029 flagellar capping protein; Reviewed; Region: fliD; PRK08032 271065002030 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 271065002031 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 271065002032 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 271065002033 Flagellar protein FliS; Region: FliS; cl00654 271065002034 Flagellar protein FliT; Region: FliT; cl05125 271065002035 Thiamin pyrophosphokinase, catalytic domain; Region: TPK_catalytic; cl09135 271065002036 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 271065002037 flagellin; Provisional; Region: PRK12802 271065002038 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 271065002039 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 271065002040 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 271065002041 signal recognition particle protein; Provisional; Region: PRK10867 271065002042 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 271065002043 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 271065002044 P loop; other site 271065002045 GTP binding site [chemical binding]; other site 271065002046 Signal peptide binding domain; Region: SRP_SPB; pfam02978 271065002047 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 271065002048 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 271065002049 RimM N-terminal domain; Region: RimM; pfam01782 271065002050 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 271065002051 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 271065002052 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 271065002053 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 271065002054 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 271065002055 DNA binding site [nucleotide binding] 271065002056 active site 271065002057 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 271065002058 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 271065002059 active site 271065002060 Int/Topo IB signature motif; other site 271065002061 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 271065002062 active site 271065002063 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 271065002064 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 271065002065 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 271065002066 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 271065002067 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 271065002068 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 271065002069 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271065002070 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065002071 Squalene epoxidase; Region: SE; pfam08491 271065002072 squalene/oxidosqualene cyclases; Region: squalene_cyclas; TIGR01787 271065002073 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 271065002074 Active site cavity [active] 271065002075 catalytic acid [active] 271065002076 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 271065002077 Cytochrome P450; Region: p450; pfam00067 271065002078 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 271065002079 ornithine cyclodeaminase; Validated; Region: PRK07589 271065002080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065002081 Ubiquitin-like proteins; Region: UBQ; cl00155 271065002082 charged pocket; other site 271065002083 hydrophobic patch; other site 271065002084 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 271065002085 NADP binding site [chemical binding]; other site 271065002086 homodimer interface [polypeptide binding]; other site 271065002087 active site 271065002088 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 271065002089 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065002090 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 271065002091 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 271065002092 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065002093 Predicted membrane protein (DUF2069); Region: DUF2069; cl01299 271065002094 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 271065002095 ArsC family; Region: ArsC; pfam03960 271065002096 catalytic residues [active] 271065002097 UbiA prenyltransferase family; Region: UbiA; cl00337 271065002098 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 271065002099 putative active site [active] 271065002100 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 271065002101 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 271065002102 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 271065002103 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 271065002104 RmuC family; Region: RmuC; pfam02646 271065002105 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 271065002106 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271065002107 ligand binding site [chemical binding]; other site 271065002108 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 271065002109 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271065002110 ATP binding site [chemical binding]; other site 271065002111 putative Mg++ binding site [ion binding]; other site 271065002112 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271065002113 nucleotide binding region [chemical binding]; other site 271065002114 ATP-binding site [chemical binding]; other site 271065002115 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 271065002116 Homo sapiens 239FB and related proteins, metallophosphatase domain; Region: MPP_239FB; cd07379 271065002117 putative active site [active] 271065002118 putative metal binding site [ion binding]; other site 271065002119 Homo sapiens 239FB and related proteins, metallophosphatase domain; Region: MPP_239FB; cd07379 271065002120 HipA N-terminal domain; Region: Couple_hipA; cl11853 271065002121 HipA-like N-terminal domain; Region: HipA_N; pfam07805 271065002122 HipA-like C-terminal domain; Region: HipA_C; pfam07804 271065002123 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 271065002124 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 271065002125 active site 271065002126 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271065002127 DNA binding site [nucleotide binding] 271065002128 active site 271065002129 Int/Topo IB signature motif; other site 271065002130 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 271065002131 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 271065002132 putative catalytic cysteine [active] 271065002133 HDOD domain; Region: HDOD; pfam08668 271065002134 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 271065002135 GAF domain; Region: GAF_2; pfam13185 271065002136 GAF domain; Region: GAF; cl15785 271065002137 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065002138 metal binding site [ion binding]; metal-binding site 271065002139 active site 271065002140 I-site; other site 271065002141 Ceramidase; Region: Ceramidase; pfam05875 271065002142 Transglycosylase SLT domain; Region: SLT_2; pfam13406 271065002143 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 271065002144 N-acetyl-D-glucosamine binding site [chemical binding]; other site 271065002145 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 271065002146 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 271065002147 catalytic residues [active] 271065002148 Domain of unknown function (DUF4266); Region: DUF4266; pfam14086 271065002149 Protein of unknown function (DUF3570); Region: DUF3570; pfam12094 271065002150 ApbE family; Region: ApbE; cl00643 271065002151 Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein [Cell envelope biogenesis, outer membrane]; Region: COG4623 271065002152 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271065002153 substrate binding pocket [chemical binding]; other site 271065002154 membrane-bound complex binding site; other site 271065002155 hinge residues; other site 271065002156 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 271065002157 N-acetyl-D-glucosamine binding site [chemical binding]; other site 271065002158 catalytic residue [active] 271065002159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 271065002160 AsmA-like C-terminal region; Region: AsmA_2; cl15864 271065002161 Family of unknown function (DUF490); Region: DUF490; pfam04357 271065002162 Family of unknown function (DUF490); Region: DUF490; pfam04357 271065002163 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 271065002164 Surface antigen; Region: Bac_surface_Ag; cl03097 271065002165 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 271065002166 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 271065002167 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065002168 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 271065002169 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 271065002170 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 271065002171 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 271065002172 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 271065002173 P-loop, Walker A motif; other site 271065002174 Base recognition motif; other site 271065002175 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 271065002176 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 271065002177 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 271065002178 putative active site [active] 271065002179 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 271065002180 formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121 271065002181 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 271065002182 active site 271065002183 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 271065002184 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065002185 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 271065002186 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 271065002187 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 271065002188 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 271065002189 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271065002190 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271065002191 thioredoxin reductase; Provisional; Region: PRK10262 271065002192 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271065002193 Protein of unknown function (DUF2959); Region: DUF2959; pfam11172 271065002194 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 271065002195 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 271065002196 G1 box; other site 271065002197 putative GEF interaction site [polypeptide binding]; other site 271065002198 GTP/Mg2+ binding site [chemical binding]; other site 271065002199 Switch I region; other site 271065002200 G2 box; other site 271065002201 G3 box; other site 271065002202 Switch II region; other site 271065002203 G4 box; other site 271065002204 G5 box; other site 271065002205 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 271065002206 DsrE/DsrF-like family; Region: DrsE; cl00672 271065002207 DsrE/DsrF-like family; Region: DrsE; cl00672 271065002208 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 271065002209 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065002210 Walker A/P-loop; other site 271065002211 ATP binding site [chemical binding]; other site 271065002212 Q-loop/lid; other site 271065002213 ABC transporter signature motif; other site 271065002214 Walker B; other site 271065002215 D-loop; other site 271065002216 H-loop/switch region; other site 271065002217 ABC transporter; Region: ABC_tran_2; pfam12848 271065002218 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 271065002219 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824 271065002220 putative hydrophobic ligand binding site [chemical binding]; other site 271065002221 Histidine kinase; Region: HisKA_3; pfam07730 271065002222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065002223 ATP binding site [chemical binding]; other site 271065002224 Mg2+ binding site [ion binding]; other site 271065002225 G-X-G motif; other site 271065002226 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 271065002227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065002228 active site 271065002229 phosphorylation site [posttranslational modification] 271065002230 intermolecular recognition site; other site 271065002231 dimerization interface [polypeptide binding]; other site 271065002232 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271065002233 DNA binding residues [nucleotide binding] 271065002234 dimerization interface [polypeptide binding]; other site 271065002235 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 271065002236 active site 271065002237 intersubunit interactions; other site 271065002238 catalytic residue [active] 271065002239 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 271065002240 Phosphotransferase enzyme family; Region: APH; pfam01636 271065002241 active site 271065002242 substrate binding site [chemical binding]; other site 271065002243 ATP binding site [chemical binding]; other site 271065002244 Formaldehyde-activating enzyme (Fae); Region: Fae; cl00774 271065002245 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 271065002246 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 271065002247 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 271065002248 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 271065002249 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 271065002250 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 271065002251 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 271065002252 Nitrogen regulatory protein P-II; Region: P-II; cl00412 271065002253 Nitrogen regulatory protein P-II; Region: P-II; smart00938 271065002254 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 271065002255 Nitrogen regulatory protein P-II; Region: P-II; cl00412 271065002256 Nitrogen regulatory protein P-II; Region: P-II; smart00938 271065002257 glutamine synthetase; Provisional; Region: glnA; PRK09469 271065002258 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 271065002259 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 271065002260 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271065002261 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 271065002262 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 271065002263 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065002264 ATP binding site [chemical binding]; other site 271065002265 Mg2+ binding site [ion binding]; other site 271065002266 G-X-G motif; other site 271065002267 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 271065002268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065002269 active site 271065002270 phosphorylation site [posttranslational modification] 271065002271 intermolecular recognition site; other site 271065002272 dimerization interface [polypeptide binding]; other site 271065002273 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065002274 Walker A motif; other site 271065002275 ATP binding site [chemical binding]; other site 271065002276 Walker B motif; other site 271065002277 arginine finger; other site 271065002278 Helix-turn-helix domains; Region: HTH; cl00088 271065002279 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 271065002280 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 271065002281 TPP-binding site [chemical binding]; other site 271065002282 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 271065002283 PYR/PP interface [polypeptide binding]; other site 271065002284 dimer interface [polypeptide binding]; other site 271065002285 TPP binding site [chemical binding]; other site 271065002286 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 271065002287 multidrug efflux protein; Reviewed; Region: PRK09579 271065002288 Protein export membrane protein; Region: SecD_SecF; cl14618 271065002289 Protein export membrane protein; Region: SecD_SecF; cl14618 271065002290 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 271065002291 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271065002292 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271065002293 Response regulator receiver domain; Region: Response_reg; pfam00072 271065002294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065002295 active site 271065002296 phosphorylation site [posttranslational modification] 271065002297 intermolecular recognition site; other site 271065002298 dimerization interface [polypeptide binding]; other site 271065002299 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065002300 PAS domain; Region: PAS_9; pfam13426 271065002301 putative active site [active] 271065002302 heme pocket [chemical binding]; other site 271065002303 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065002304 metal binding site [ion binding]; metal-binding site 271065002305 active site 271065002306 I-site; other site 271065002307 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065002308 Response regulator receiver domain; Region: Response_reg; pfam00072 271065002309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065002310 active site 271065002311 phosphorylation site [posttranslational modification] 271065002312 intermolecular recognition site; other site 271065002313 dimerization interface [polypeptide binding]; other site 271065002314 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 271065002315 PAS domain S-box; Region: sensory_box; TIGR00229 271065002316 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065002317 putative active site [active] 271065002318 heme pocket [chemical binding]; other site 271065002319 PAS domain S-box; Region: sensory_box; TIGR00229 271065002320 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065002321 putative active site [active] 271065002322 heme pocket [chemical binding]; other site 271065002323 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 271065002324 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065002325 dimer interface [polypeptide binding]; other site 271065002326 phosphorylation site [posttranslational modification] 271065002327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065002328 ATP binding site [chemical binding]; other site 271065002329 Mg2+ binding site [ion binding]; other site 271065002330 G-X-G motif; other site 271065002331 PAS domain S-box; Region: sensory_box; TIGR00229 271065002332 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065002333 putative active site [active] 271065002334 heme pocket [chemical binding]; other site 271065002335 GAF domain; Region: GAF_2; pfam13185 271065002336 GAF domain; Region: GAF; cl15785 271065002337 PAS fold; Region: PAS; pfam00989 271065002338 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065002339 putative active site [active] 271065002340 heme pocket [chemical binding]; other site 271065002341 GAF domain; Region: GAF_2; pfam13185 271065002342 GAF domain; Region: GAF; cl15785 271065002343 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 271065002344 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 271065002345 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 271065002346 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 271065002347 putative ligand binding site [chemical binding]; other site 271065002348 PAS domain S-box; Region: sensory_box; TIGR00229 271065002349 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065002350 putative active site [active] 271065002351 heme pocket [chemical binding]; other site 271065002352 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065002353 metal binding site [ion binding]; metal-binding site 271065002354 active site 271065002355 I-site; other site 271065002356 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065002357 Sensors of blue-light using FAD; Region: BLUF; cl04855 271065002358 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 271065002359 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 271065002360 NAD(P) binding site [chemical binding]; other site 271065002361 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 271065002362 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 271065002363 active site residue [active] 271065002364 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 271065002365 active site residue [active] 271065002366 NAD synthetase; Provisional; Region: PRK13981 271065002367 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 271065002368 multimer interface [polypeptide binding]; other site 271065002369 active site 271065002370 catalytic triad [active] 271065002371 protein interface 1 [polypeptide binding]; other site 271065002372 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 271065002373 homodimer interface [polypeptide binding]; other site 271065002374 NAD binding pocket [chemical binding]; other site 271065002375 ATP binding pocket [chemical binding]; other site 271065002376 Mg binding site [ion binding]; other site 271065002377 active-site loop [active] 271065002378 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 271065002379 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 271065002380 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 271065002381 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271065002382 FeS/SAM binding site; other site 271065002383 TRAM domain; Region: TRAM; cl01282 271065002384 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 271065002385 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065002386 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 271065002387 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 271065002388 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 271065002389 Transporter associated domain; Region: CorC_HlyC; cl08393 271065002390 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 271065002391 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271065002392 TPR motif; other site 271065002393 binding surface 271065002394 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271065002395 TPR motif; other site 271065002396 binding surface 271065002397 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271065002398 binding surface 271065002399 TPR motif; other site 271065002400 Nidogen-like; Region: NIDO; cl02648 271065002401 PEP-CTERM motif; Region: VPEP; cl15443 271065002402 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 271065002403 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 271065002404 META domain; Region: META; cl01245 271065002405 META domain; Region: META; cl01245 271065002406 aspartate aminotransferase; Provisional; Region: PRK05764 271065002407 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271065002408 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271065002409 homodimer interface [polypeptide binding]; other site 271065002410 catalytic residue [active] 271065002411 excinuclease ABC subunit B; Provisional; Region: PRK05298 271065002412 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271065002413 ATP binding site [chemical binding]; other site 271065002414 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271065002415 nucleotide binding region [chemical binding]; other site 271065002416 ATP-binding site [chemical binding]; other site 271065002417 Ultra-violet resistance protein B; Region: UvrB; pfam12344 271065002418 UvrB/uvrC motif; Region: UVR; pfam02151 271065002419 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 271065002420 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 271065002421 CheB methylesterase; Region: CheB_methylest; pfam01339 271065002422 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 271065002423 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 271065002424 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065002425 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271065002426 PAS fold; Region: PAS_4; pfam08448 271065002427 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065002428 PAS domain; Region: PAS_9; pfam13426 271065002429 putative active site [active] 271065002430 heme pocket [chemical binding]; other site 271065002431 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065002432 metal binding site [ion binding]; metal-binding site 271065002433 active site 271065002434 I-site; other site 271065002435 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065002436 PAS fold; Region: PAS_2; pfam08446 271065002437 GAF domain; Region: GAF; cl15785 271065002438 Phytochrome region; Region: PHY; pfam00360 271065002439 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 271065002440 heme binding pocket [chemical binding]; other site 271065002441 heme ligand [chemical binding]; other site 271065002442 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 271065002443 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 271065002444 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 271065002445 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 271065002446 active site 271065002447 dimer interface [polypeptide binding]; other site 271065002448 motif 1; other site 271065002449 motif 2; other site 271065002450 motif 3; other site 271065002451 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 271065002452 anticodon binding site; other site 271065002453 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 271065002454 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 271065002455 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 271065002456 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 271065002457 ribosomal protein L20; Region: rpl20; CHL00068 271065002458 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 271065002459 23S rRNA binding site [nucleotide binding]; other site 271065002460 L21 binding site [polypeptide binding]; other site 271065002461 L13 binding site [polypeptide binding]; other site 271065002462 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 271065002463 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 271065002464 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 271065002465 dimer interface [polypeptide binding]; other site 271065002466 motif 1; other site 271065002467 active site 271065002468 motif 2; other site 271065002469 motif 3; other site 271065002470 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 271065002471 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 271065002472 putative tRNA-binding site [nucleotide binding]; other site 271065002473 B3/4 domain; Region: B3_4; cl11458 271065002474 tRNA synthetase B5 domain; Region: B5; cl08394 271065002475 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 271065002476 dimer interface [polypeptide binding]; other site 271065002477 motif 1; other site 271065002478 motif 3; other site 271065002479 motif 2; other site 271065002480 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 271065002481 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 271065002482 IHF dimer interface [polypeptide binding]; other site 271065002483 IHF - DNA interface [nucleotide binding]; other site 271065002484 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 271065002485 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 271065002486 DNA binding residues [nucleotide binding] 271065002487 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 271065002488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 271065002489 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065002490 Walker A motif; other site 271065002491 ATP binding site [chemical binding]; other site 271065002492 Walker B motif; other site 271065002493 arginine finger; other site 271065002494 Helix-turn-helix domains; Region: HTH; cl00088 271065002495 sensory histidine kinase AtoS; Provisional; Region: PRK11360 271065002496 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065002497 dimer interface [polypeptide binding]; other site 271065002498 phosphorylation site [posttranslational modification] 271065002499 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065002500 ATP binding site [chemical binding]; other site 271065002501 Mg2+ binding site [ion binding]; other site 271065002502 G-X-G motif; other site 271065002503 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 271065002504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065002505 active site 271065002506 phosphorylation site [posttranslational modification] 271065002507 intermolecular recognition site; other site 271065002508 dimerization interface [polypeptide binding]; other site 271065002509 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065002510 Walker A motif; other site 271065002511 ATP binding site [chemical binding]; other site 271065002512 Walker B motif; other site 271065002513 arginine finger; other site 271065002514 Helix-turn-helix domains; Region: HTH; cl00088 271065002515 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 271065002516 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 271065002517 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 271065002518 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 271065002519 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 271065002520 MgtE intracellular N domain; Region: MgtE_N; cl15244 271065002521 FliG C-terminal domain; Region: FliG_C; pfam01706 271065002522 flagellar assembly protein H; Validated; Region: fliH; PRK05687 271065002523 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 271065002524 Flagellar assembly protein FliH; Region: FliH; pfam02108 271065002525 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 271065002526 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 271065002527 Walker A motif/ATP binding site; other site 271065002528 Walker B motif; other site 271065002529 flagellar biosynthesis chaperone; Validated; Region: fliJ; cl09161 271065002530 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 271065002531 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 271065002532 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 271065002533 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 271065002534 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 271065002535 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 271065002536 active site 271065002537 ATP binding site [chemical binding]; other site 271065002538 Cupin domain; Region: Cupin_2; cl09118 271065002539 DoxX; Region: DoxX; cl00976 271065002540 TMAO/DMSO reductase; Reviewed; Region: PRK05363 271065002541 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 271065002542 Moco binding site; other site 271065002543 metal coordination site [ion binding]; other site 271065002544 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 271065002545 octamerization interface [polypeptide binding]; other site 271065002546 diferric-oxygen binding site [ion binding]; other site 271065002547 PAS fold; Region: PAS; pfam00989 271065002548 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065002549 putative active site [active] 271065002550 heme pocket [chemical binding]; other site 271065002551 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 271065002552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065002553 ATP binding site [chemical binding]; other site 271065002554 Mg2+ binding site [ion binding]; other site 271065002555 G-X-G motif; other site 271065002556 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 271065002557 G1 box; other site 271065002558 GTP/Mg2+ binding site [chemical binding]; other site 271065002559 G2 box; other site 271065002560 Switch I region; other site 271065002561 G3 box; other site 271065002562 Switch II region; other site 271065002563 G4 box; other site 271065002564 G5 box; other site 271065002565 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 271065002566 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 271065002567 dimer interface [polypeptide binding]; other site 271065002568 phosphorylation site [posttranslational modification] 271065002569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065002570 ATP binding site [chemical binding]; other site 271065002571 Mg2+ binding site [ion binding]; other site 271065002572 G-X-G motif; other site 271065002573 Response regulator receiver domain; Region: Response_reg; pfam00072 271065002574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065002575 active site 271065002576 phosphorylation site [posttranslational modification] 271065002577 intermolecular recognition site; other site 271065002578 dimerization interface [polypeptide binding]; other site 271065002579 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 271065002580 general secretory pathway protein E; Region: type_II_gspE; TIGR02533 271065002581 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 271065002582 Walker A motif; other site 271065002583 ATP binding site [chemical binding]; other site 271065002584 Walker B motif; other site 271065002585 Transposase domain (DUF772); Region: DUF772; cl15789 271065002586 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 271065002587 Transposase domain (DUF772); Region: DUF772; cl15789 271065002588 Response regulator receiver domain; Region: Response_reg; pfam00072 271065002589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065002590 active site 271065002591 phosphorylation site [posttranslational modification] 271065002592 intermolecular recognition site; other site 271065002593 dimerization interface [polypeptide binding]; other site 271065002594 GAF domain; Region: GAF_2; pfam13185 271065002595 GAF domain; Region: GAF; cl15785 271065002596 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065002597 PAS fold; Region: PAS_3; pfam08447 271065002598 putative active site [active] 271065002599 heme pocket [chemical binding]; other site 271065002600 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065002601 dimer interface [polypeptide binding]; other site 271065002602 phosphorylation site [posttranslational modification] 271065002603 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065002604 ATP binding site [chemical binding]; other site 271065002605 Mg2+ binding site [ion binding]; other site 271065002606 G-X-G motif; other site 271065002607 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065002608 metal binding site [ion binding]; metal-binding site 271065002609 active site 271065002610 I-site; other site 271065002611 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 271065002612 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 271065002613 active site 271065002614 (T/H)XGH motif; other site 271065002615 ferredoxin; Validated; Region: PRK07118 271065002616 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 271065002617 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 271065002618 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271065002619 FeS/SAM binding site; other site 271065002620 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 271065002621 ribosome maturation protein RimP; Reviewed; Region: PRK00092 271065002622 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 271065002623 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 271065002624 Sm1 motif; other site 271065002625 D1 - D2 interaction site; other site 271065002626 D3 - B interaction site; other site 271065002627 Hfq - Hfq interaction site; other site 271065002628 RNA binding pocket [nucleotide binding]; other site 271065002629 Sm2 motif; other site 271065002630 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 271065002631 NusA N-terminal domain; Region: NusA_N; pfam08529 271065002632 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 271065002633 RNA binding site [nucleotide binding]; other site 271065002634 homodimer interface [polypeptide binding]; other site 271065002635 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 271065002636 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 271065002637 G-X-X-G motif; other site 271065002638 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 271065002639 translation initiation factor IF-2; Validated; Region: infB; PRK05306 271065002640 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 271065002641 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 271065002642 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 271065002643 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 271065002644 G1 box; other site 271065002645 putative GEF interaction site [polypeptide binding]; other site 271065002646 GTP/Mg2+ binding site [chemical binding]; other site 271065002647 Switch I region; other site 271065002648 G2 box; other site 271065002649 G3 box; other site 271065002650 Switch II region; other site 271065002651 G4 box; other site 271065002652 G5 box; other site 271065002653 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 271065002654 Translation-initiation factor 2; Region: IF-2; pfam11987 271065002655 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 271065002656 Ribosome-binding factor A; Region: RBFA; cl00542 271065002657 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 271065002658 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 271065002659 RNA binding site [nucleotide binding]; other site 271065002660 active site 271065002661 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 271065002662 16S/18S rRNA binding site [nucleotide binding]; other site 271065002663 S13e-L30e interaction site [polypeptide binding]; other site 271065002664 25S rRNA binding site [nucleotide binding]; other site 271065002665 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 271065002666 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 271065002667 RNase E interface [polypeptide binding]; other site 271065002668 trimer interface [polypeptide binding]; other site 271065002669 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 271065002670 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 271065002671 RNase E interface [polypeptide binding]; other site 271065002672 trimer interface [polypeptide binding]; other site 271065002673 active site 271065002674 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 271065002675 putative nucleic acid binding region [nucleotide binding]; other site 271065002676 G-X-X-G motif; other site 271065002677 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 271065002678 RNA binding site [nucleotide binding]; other site 271065002679 domain interface; other site 271065002680 Cytochrome c; Region: Cytochrom_C; cl11414 271065002681 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 271065002682 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 271065002683 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271065002684 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233 271065002685 putative active site [active] 271065002686 Zn binding site [ion binding]; other site 271065002687 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 271065002688 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271065002689 Coenzyme A binding pocket [chemical binding]; other site 271065002690 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 271065002691 Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751 271065002692 TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779 271065002693 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 271065002694 N-terminal plug; other site 271065002695 ligand-binding site [chemical binding]; other site 271065002696 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 271065002697 homotrimer interface [polypeptide binding]; other site 271065002698 Walker A motif; other site 271065002699 GTP binding site [chemical binding]; other site 271065002700 Walker B motif; other site 271065002701 cobyric acid synthase; Provisional; Region: PRK00784 271065002702 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065002703 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065002704 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 271065002705 catalytic triad [active] 271065002706 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 271065002707 catalytic core [active] 271065002708 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 271065002709 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 271065002710 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 271065002711 catalytic triad [active] 271065002712 integrase/recombinase; Provisional; Region: PRK15417 271065002713 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271065002714 Domain of unknown function DUF29; Region: DUF29; pfam01724 271065002715 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 271065002716 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 271065002717 putative dimer interface [polypeptide binding]; other site 271065002718 active site pocket [active] 271065002719 putative cataytic base [active] 271065002720 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 271065002721 FMN binding site [chemical binding]; other site 271065002722 dimer interface [polypeptide binding]; other site 271065002723 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 271065002724 putative active site [active] 271065002725 putative substrate binding site [chemical binding]; other site 271065002726 ATP binding site [chemical binding]; other site 271065002727 CobD/Cbib protein; Region: CobD_Cbib; cl00561 271065002728 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 271065002729 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271065002730 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271065002731 homodimer interface [polypeptide binding]; other site 271065002732 catalytic residue [active] 271065002733 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 271065002734 active site residue [active] 271065002735 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 271065002736 trehalose synthase; Region: treS_nterm; TIGR02456 271065002737 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 271065002738 active site 271065002739 catalytic site [active] 271065002740 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 271065002741 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 271065002742 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 271065002743 FAD binding domain; Region: FAD_binding_4; pfam01565 271065002744 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 271065002745 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 271065002746 Cysteine-rich domain; Region: CCG; pfam02754 271065002747 Cysteine-rich domain; Region: CCG; pfam02754 271065002748 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 271065002749 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 271065002750 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 271065002751 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 271065002752 This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export...; Region: ABCC_Protease_Secretion; cd03246 271065002753 Walker A/P-loop; other site 271065002754 ATP binding site [chemical binding]; other site 271065002755 Q-loop/lid; other site 271065002756 ABC transporter signature motif; other site 271065002757 Walker B; other site 271065002758 D-loop; other site 271065002759 H-loop/switch region; other site 271065002760 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 271065002761 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271065002762 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271065002763 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 271065002764 SapC; Region: SapC; pfam07277 271065002765 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 271065002766 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 271065002767 Integrase core domain; Region: rve; cl01316 271065002768 transposase; Provisional; Region: PRK06526 271065002769 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065002770 Walker A motif; other site 271065002771 ATP binding site [chemical binding]; other site 271065002772 Walker B motif; other site 271065002773 rod shape-determining protein MreC; Provisional; Region: PRK13922 271065002774 Integrase core domain; Region: rve; cl01316 271065002775 Integrase core domain; Region: rve_3; cl15866 271065002776 phosphodiesterase; Provisional; Region: PRK12704 271065002777 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 271065002778 Transposase; Region: DDE_Tnp_ISL3; pfam01610 271065002779 Transposase domain (DUF772); Region: DUF772; cl15789 271065002780 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 271065002781 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 271065002782 FlgN protein; Region: FlgN; cl09176 271065002783 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 271065002784 SAF domain; Region: SAF; cl00555 271065002785 SAF-like; Region: SAF_2; pfam13144 271065002786 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 271065002787 Response regulator receiver domain; Region: Response_reg; pfam00072 271065002788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065002789 active site 271065002790 phosphorylation site [posttranslational modification] 271065002791 intermolecular recognition site; other site 271065002792 dimerization interface [polypeptide binding]; other site 271065002793 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 271065002794 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 271065002795 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065002796 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 271065002797 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 271065002798 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 271065002799 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 271065002800 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 271065002801 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK12634 271065002802 FlgD Ig-like domain; Region: FlgD_ig; cl15790 271065002803 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 271065002804 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 271065002805 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 271065002806 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 271065002807 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 271065002808 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 271065002809 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 271065002810 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 271065002811 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 271065002812 Flagellar L-ring protein; Region: FlgH; cl00905 271065002813 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 271065002814 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 271065002815 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 271065002816 Rod binding protein; Region: Rod-binding; cl01626 271065002817 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 271065002818 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 271065002819 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 271065002820 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 271065002821 flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550 271065002822 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 271065002823 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 271065002824 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 271065002825 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 271065002826 MEKHLA domain; Region: MEKHLA; pfam08670 271065002827 Acylphosphatase; Region: Acylphosphatase; cl00551 271065002828 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 271065002829 THUMP domain; Region: THUMP; cl12076 271065002830 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065002831 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065002832 S-adenosylmethionine binding site [chemical binding]; other site 271065002833 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065002834 ribonuclease D; Region: rnd; TIGR01388 271065002835 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 271065002836 catalytic site [active] 271065002837 putative active site [active] 271065002838 putative substrate binding site [chemical binding]; other site 271065002839 HRDC domain; Region: HRDC; cl02578 271065002840 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 271065002841 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 271065002842 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 271065002843 dimerization interface [polypeptide binding]; other site 271065002844 two component system sensor kinase SsrA; Provisional; Region: PRK15347 271065002845 PAS domain S-box; Region: sensory_box; TIGR00229 271065002846 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065002847 putative active site [active] 271065002848 heme pocket [chemical binding]; other site 271065002849 PAS domain S-box; Region: sensory_box; TIGR00229 271065002850 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065002851 putative active site [active] 271065002852 heme pocket [chemical binding]; other site 271065002853 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065002854 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 271065002855 putative active site [active] 271065002856 heme pocket [chemical binding]; other site 271065002857 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065002858 dimer interface [polypeptide binding]; other site 271065002859 phosphorylation site [posttranslational modification] 271065002860 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065002861 ATP binding site [chemical binding]; other site 271065002862 Mg2+ binding site [ion binding]; other site 271065002863 G-X-G motif; other site 271065002864 Response regulator receiver domain; Region: Response_reg; pfam00072 271065002865 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065002866 active site 271065002867 phosphorylation site [posttranslational modification] 271065002868 intermolecular recognition site; other site 271065002869 dimerization interface [polypeptide binding]; other site 271065002870 Response regulator receiver domain; Region: Response_reg; pfam00072 271065002871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065002872 active site 271065002873 phosphorylation site [posttranslational modification] 271065002874 intermolecular recognition site; other site 271065002875 dimerization interface [polypeptide binding]; other site 271065002876 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 271065002877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065002878 active site 271065002879 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 271065002880 phosphorylation site [posttranslational modification] 271065002881 intermolecular recognition site; other site 271065002882 dimerization interface [polypeptide binding]; other site 271065002883 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065002884 putative active site [active] 271065002885 heme pocket [chemical binding]; other site 271065002886 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065002887 metal binding site [ion binding]; metal-binding site 271065002888 active site 271065002889 I-site; other site 271065002890 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065002891 glycine dehydrogenase; Provisional; Region: PRK05367 271065002892 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 271065002893 tetramer interface [polypeptide binding]; other site 271065002894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271065002895 catalytic residue [active] 271065002896 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 271065002897 tetramer interface [polypeptide binding]; other site 271065002898 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271065002899 catalytic residue [active] 271065002900 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 271065002901 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 271065002902 HDOD domain; Region: HDOD; pfam08668 271065002903 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 271065002904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065002905 active site 271065002906 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 271065002907 phosphorylation site [posttranslational modification] 271065002908 intermolecular recognition site; other site 271065002909 dimerization interface [polypeptide binding]; other site 271065002910 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271065002911 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065002912 metal binding site [ion binding]; metal-binding site 271065002913 active site 271065002914 I-site; other site 271065002915 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065002916 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271065002917 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 271065002918 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271065002919 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271065002920 Protein of unknown function (DUF502); Region: DUF502; cl01107 271065002921 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 271065002922 GTPase RsgA; Reviewed; Region: PRK00098 271065002923 RNA binding site [nucleotide binding]; other site 271065002924 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 271065002925 GTPase/Zn-binding domain interface [polypeptide binding]; other site 271065002926 GTP/Mg2+ binding site [chemical binding]; other site 271065002927 G4 box; other site 271065002928 G5 box; other site 271065002929 G1 box; other site 271065002930 Switch I region; other site 271065002931 G2 box; other site 271065002932 G3 box; other site 271065002933 Switch II region; other site 271065002934 Peptidase family M48; Region: Peptidase_M48; cl12018 271065002935 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 271065002936 catalytic site [active] 271065002937 putative active site [active] 271065002938 putative substrate binding site [chemical binding]; other site 271065002939 dimer interface [polypeptide binding]; other site 271065002940 CrcB-like protein; Region: CRCB; cl09114 271065002941 CrcB-like protein; Region: CRCB; cl09114 271065002942 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 271065002943 seryl-tRNA synthetase; Provisional; Region: PRK05431 271065002944 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 271065002945 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 271065002946 dimer interface [polypeptide binding]; other site 271065002947 active site 271065002948 motif 1; other site 271065002949 motif 2; other site 271065002950 motif 3; other site 271065002951 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271065002952 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 271065002953 CheB methylesterase; Region: CheB_methylest; pfam01339 271065002954 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 271065002955 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 271065002956 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065002957 PAS domain; Region: PAS_10; pfam13596 271065002958 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065002959 PAS domain; Region: PAS_9; pfam13426 271065002960 putative active site [active] 271065002961 heme pocket [chemical binding]; other site 271065002962 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065002963 metal binding site [ion binding]; metal-binding site 271065002964 active site 271065002965 I-site; other site 271065002966 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065002967 Cytochrome c; Region: Cytochrom_C; cl11414 271065002968 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 271065002969 thiamine phosphate binding site [chemical binding]; other site 271065002970 active site 271065002971 pyrophosphate binding site [ion binding]; other site 271065002972 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 271065002973 dimer interface [polypeptide binding]; other site 271065002974 substrate binding site [chemical binding]; other site 271065002975 ATP binding site [chemical binding]; other site 271065002976 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 271065002977 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 271065002978 catalytic residues [active] 271065002979 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 271065002980 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065002981 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 271065002982 putative L-serine binding site [chemical binding]; other site 271065002983 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271065002984 phosphoserine phosphatase SerB; Region: serB; TIGR00338 271065002985 Transcriptional regulator; Region: Transcrip_reg; cl00361 271065002986 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 271065002987 active site 271065002988 putative DNA-binding cleft [nucleotide binding]; other site 271065002989 dimer interface [polypeptide binding]; other site 271065002990 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 271065002991 RuvA N terminal domain; Region: RuvA_N; pfam01330 271065002992 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 271065002993 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 271065002994 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065002995 Walker A motif; other site 271065002996 ATP binding site [chemical binding]; other site 271065002997 Walker B motif; other site 271065002998 arginine finger; other site 271065002999 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 271065003000 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 271065003001 active site 271065003002 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 271065003003 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 271065003004 Gram-negative bacterial tonB protein; Region: TonB; cl10048 271065003005 translocation protein TolB; Provisional; Region: tolB; PRK04922 271065003006 TolB amino-terminal domain; Region: TolB_N; cl00639 271065003007 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 271065003008 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 271065003009 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 271065003010 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271065003011 ligand binding site [chemical binding]; other site 271065003012 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 271065003013 Tetratricopeptide repeat; Region: TPR_6; pfam13174 271065003014 Tetratricopeptide repeat; Region: TPR_6; pfam13174 271065003015 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963 271065003016 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271065003017 FeS/SAM binding site; other site 271065003018 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 271065003019 Ligand Binding Site [chemical binding]; other site 271065003020 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 271065003021 Int/Topo IB signature motif; other site 271065003022 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 271065003023 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 271065003024 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271065003025 FeS/SAM binding site; other site 271065003026 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 271065003027 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 271065003028 catalytic motif [active] 271065003029 Catalytic residue [active] 271065003030 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 271065003031 Type II transport protein GspH; Region: GspH; pfam12019 271065003032 hypothetical protein; Provisional; Region: PRK10557 271065003033 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 271065003034 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065003035 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 271065003036 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 271065003037 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 271065003038 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 271065003039 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 271065003040 active site 271065003041 DNA binding site [nucleotide binding] 271065003042 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 271065003043 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 271065003044 Catalytic site [active] 271065003045 Cupin domain; Region: Cupin_2; cl09118 271065003046 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 271065003047 Catalytic site [active] 271065003048 LexA repressor; Validated; Region: PRK00215 271065003049 Helix-turn-helix domains; Region: HTH; cl00088 271065003050 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 271065003051 Catalytic site [active] 271065003052 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 271065003053 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 271065003054 Helix-turn-helix domains; Region: HTH; cl00088 271065003055 Cupin domain; Region: Cupin_2; cl09118 271065003056 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 271065003057 Transposase; Region: DDE_Tnp_ISL3; pfam01610 271065003058 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723 271065003059 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723 271065003060 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 271065003061 dimer interface [polypeptide binding]; other site 271065003062 substrate binding site [chemical binding]; other site 271065003063 metal binding sites [ion binding]; metal-binding site 271065003064 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 271065003065 MgtE intracellular N domain; Region: MgtE_N; cl15244 271065003066 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 271065003067 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 271065003068 Divalent cation transporter; Region: MgtE; cl00786 271065003069 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 271065003070 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 271065003071 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 271065003072 NADPH bind site [chemical binding]; other site 271065003073 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 271065003074 putative FMN binding site [chemical binding]; other site 271065003075 NADPH bind site [chemical binding]; other site 271065003076 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 271065003077 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 271065003078 HDOD domain; Region: HDOD; pfam08668 271065003079 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 271065003080 GAF domain; Region: GAF; cl15785 271065003081 Transposase; Region: DEDD_Tnp_IS110; pfam01548 271065003082 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 271065003083 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 271065003084 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065003085 CoA-ligase; Region: Ligase_CoA; cl02894 271065003086 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271065003087 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 271065003088 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271065003089 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 271065003090 Uncharacterized conserved protein [Function unknown]; Region: COG2308 271065003091 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 271065003092 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 271065003093 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065003094 metal binding site [ion binding]; metal-binding site 271065003095 active site 271065003096 I-site; other site 271065003097 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065003098 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 271065003099 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192 271065003100 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271065003101 active site 271065003102 motif I; other site 271065003103 motif II; other site 271065003104 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065003105 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 271065003106 Predicted membrane protein [Function unknown]; Region: COG2119 271065003107 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 271065003108 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 271065003109 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 271065003110 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 271065003111 G1 box; other site 271065003112 GTP/Mg2+ binding site [chemical binding]; other site 271065003113 G2 box; other site 271065003114 Switch I region; other site 271065003115 G3 box; other site 271065003116 Switch II region; other site 271065003117 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 271065003118 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065003119 GTP/Mg2+ binding site [chemical binding]; other site 271065003120 G4 box; other site 271065003121 G5 box; other site 271065003122 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065003123 G1 box; other site 271065003124 G1 box; other site 271065003125 GTP/Mg2+ binding site [chemical binding]; other site 271065003126 Switch I region; other site 271065003127 G2 box; other site 271065003128 G2 box; other site 271065003129 Switch I region; other site 271065003130 G3 box; other site 271065003131 G3 box; other site 271065003132 Switch II region; other site 271065003133 Switch II region; other site 271065003134 G4 box; other site 271065003135 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 271065003136 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 271065003137 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 271065003138 ligand binding site [chemical binding]; other site 271065003139 flexible hinge region; other site 271065003140 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 271065003141 phosphopeptide binding site; other site 271065003142 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065003143 metal binding site [ion binding]; metal-binding site 271065003144 active site 271065003145 I-site; other site 271065003146 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 271065003147 nudix motif; other site 271065003148 Cytochrome c; Region: Cytochrom_C; cl11414 271065003149 Cytochrome c; Region: Cytochrom_C; cl11414 271065003150 malate dehydrogenase; Provisional; Region: PRK13529 271065003151 Malic enzyme, N-terminal domain; Region: malic; pfam00390 271065003152 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 271065003153 NAD(P) binding site [chemical binding]; other site 271065003154 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 271065003155 homodimer interface [polypeptide binding]; other site 271065003156 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 271065003157 active site pocket [active] 271065003158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065003159 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 271065003160 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 271065003161 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 271065003162 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 271065003163 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 271065003164 DNA-K related protein; Region: DUF3731; pfam12531 271065003165 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 271065003166 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 271065003167 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 271065003168 MutS domain I; Region: MutS_I; pfam01624 271065003169 MutS domain II; Region: MutS_II; pfam05188 271065003170 MutS family domain IV; Region: MutS_IV; pfam05190 271065003171 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 271065003172 Walker A/P-loop; other site 271065003173 ATP binding site [chemical binding]; other site 271065003174 Q-loop/lid; other site 271065003175 ABC transporter signature motif; other site 271065003176 Walker B; other site 271065003177 D-loop; other site 271065003178 H-loop/switch region; other site 271065003179 Competence-damaged protein; Region: CinA; cl00666 271065003180 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 271065003181 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065003182 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 271065003183 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 271065003184 NMT1-like family; Region: NMT1_2; cl15260 271065003185 Winged helix-turn helix; Region: HTH_29; pfam13551 271065003186 Helix-turn-helix domains; Region: HTH; cl00088 271065003187 Integrase core domain; Region: rve; cl01316 271065003188 Integrase core domain; Region: rve_3; cl15866 271065003189 Helix-turn-helix domains; Region: HTH; cl00088 271065003190 rod shape-determining protein MreC; Provisional; Region: PRK13922 271065003191 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 271065003192 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065003193 Walker A/P-loop; other site 271065003194 ATP binding site [chemical binding]; other site 271065003195 Q-loop/lid; other site 271065003196 ABC transporter signature motif; other site 271065003197 Walker B; other site 271065003198 D-loop; other site 271065003199 H-loop/switch region; other site 271065003200 TOBE domain; Region: TOBE_2; cl01440 271065003201 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 271065003202 Sel1 repeat; Region: Sel1; cl02723 271065003203 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 271065003204 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 271065003205 active site 271065003206 HIGH motif; other site 271065003207 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 271065003208 active site 271065003209 KMSKS motif; other site 271065003210 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 271065003211 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 271065003212 heme binding site [chemical binding]; other site 271065003213 ferroxidase pore; other site 271065003214 ferroxidase diiron center [ion binding]; other site 271065003215 putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073 271065003216 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 271065003217 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 271065003218 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 271065003219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271065003220 glutathione reductase; Validated; Region: PRK06116 271065003221 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271065003222 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 271065003223 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 271065003224 catalytic triad [active] 271065003225 dimer interface [polypeptide binding]; other site 271065003226 Uncharacterized conserved protein [Function unknown]; Region: COG3461 271065003227 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 271065003228 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 271065003229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 271065003230 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065003231 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 271065003232 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 271065003233 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 271065003234 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 271065003235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 271065003236 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 271065003237 Sulfate transporter family; Region: Sulfate_transp; cl15842 271065003238 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 271065003239 Sulfate transporter family; Region: Sulfate_transp; cl15842 271065003240 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 271065003241 Predicted transcriptional regulator [Transcription]; Region: COG2345 271065003242 Heme NO binding; Region: HNOB; cl15268 271065003243 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 271065003244 apolar tunnel; other site 271065003245 heme binding site [chemical binding]; other site 271065003246 dimerization interface [polypeptide binding]; other site 271065003247 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 271065003248 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 271065003249 catalytic loop [active] 271065003250 iron binding site [ion binding]; other site 271065003251 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 271065003252 FAD binding pocket [chemical binding]; other site 271065003253 FAD binding motif [chemical binding]; other site 271065003254 phosphate binding motif [ion binding]; other site 271065003255 beta-alpha-beta structure motif; other site 271065003256 NAD binding pocket [chemical binding]; other site 271065003257 Cytochrome c; Region: Cytochrom_C; cl11414 271065003258 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 271065003259 Low-spin heme binding site [chemical binding]; other site 271065003260 D-pathway; other site 271065003261 Putative water exit pathway; other site 271065003262 Binuclear center (active site) [active] 271065003263 K-pathway; other site 271065003264 Putative proton exit pathway; other site 271065003265 Protein of unknown function DUF45; Region: DUF45; cl00636 271065003266 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 271065003267 catalytic residues [active] 271065003268 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 271065003269 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 271065003270 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 271065003271 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 271065003272 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 271065003273 putative active site [active] 271065003274 metal binding site [ion binding]; metal-binding site 271065003275 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 271065003276 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 271065003277 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 271065003278 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 271065003279 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271065003280 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 271065003281 cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007 271065003282 D-pathway; other site 271065003283 Putative ubiquinol binding site [chemical binding]; other site 271065003284 Low-spin heme (heme b) binding site [chemical binding]; other site 271065003285 Putative water exit pathway; other site 271065003286 Binuclear center (heme o3/CuB) [ion binding]; other site 271065003287 K-pathway; other site 271065003288 Putative proton exit pathway; other site 271065003289 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 271065003290 Subunit I/III interface [polypeptide binding]; other site 271065003291 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 271065003292 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 271065003293 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 271065003294 active site 271065003295 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 271065003296 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 271065003297 active site 271065003298 NTP binding site [chemical binding]; other site 271065003299 metal binding triad [ion binding]; metal-binding site 271065003300 antibiotic binding site [chemical binding]; other site 271065003301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065003302 S-adenosylmethionine binding site [chemical binding]; other site 271065003303 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 271065003304 PLD-like domain; Region: PLDc_2; pfam13091 271065003305 putative active site [active] 271065003306 catalytic site [active] 271065003307 DEAD-like helicases superfamily; Region: DEXDc; smart00487 271065003308 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271065003309 ATP binding site [chemical binding]; other site 271065003310 putative Mg++ binding site [ion binding]; other site 271065003311 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271065003312 nucleotide binding region [chemical binding]; other site 271065003313 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 271065003314 Catalytic site [active] 271065003315 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271065003316 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271065003317 Restriction endonuclease; Region: Mrr_cat; cl00516 271065003318 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271065003319 ATP binding site [chemical binding]; other site 271065003320 putative Mg++ binding site [ion binding]; other site 271065003321 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271065003322 nucleotide binding region [chemical binding]; other site 271065003323 Helicase subunit of the DNA excision repair complex [DNA replication, recombination, and repair]; Region: UvrB; COG0556 271065003324 ATP-binding site [chemical binding]; other site 271065003325 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 271065003326 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 271065003327 active site 271065003328 NTP binding site [chemical binding]; other site 271065003329 metal binding triad [ion binding]; metal-binding site 271065003330 antibiotic binding site [chemical binding]; other site 271065003331 Protein of unknown function DUF86; Region: DUF86; cl01031 271065003332 Transposase domain (DUF772); Region: DUF772; cl15789 271065003333 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 271065003334 Transposase domain (DUF772); Region: DUF772; cl15789 271065003335 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 271065003336 putative active site [active] 271065003337 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 271065003338 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 271065003339 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 271065003340 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 271065003341 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 271065003342 Protein of unknown function (DUF3680); Region: DUF3680; cl02189 271065003343 TolB amino-terminal domain; Region: TolB_N; cl00639 271065003344 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 271065003345 Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813 271065003346 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271065003347 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 271065003348 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 271065003349 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 271065003350 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065003351 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 271065003352 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 271065003353 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271065003354 catalytic residue [active] 271065003355 Short C-terminal domain; Region: SHOCT; cl01373 271065003356 SWIM zinc finger; Region: SWIM; cl15408 271065003357 Methyltransferase domain; Region: Methyltransf_31; pfam13847 271065003358 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065003359 S-adenosylmethionine binding site [chemical binding]; other site 271065003360 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 271065003361 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 271065003362 catalytic residues [active] 271065003363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 271065003364 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 271065003365 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 271065003366 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 271065003367 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 271065003368 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 271065003369 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 271065003370 Tetratricopeptide repeat; Region: TPR_6; pfam13174 271065003371 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 271065003372 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 271065003373 RNA binding surface [nucleotide binding]; other site 271065003374 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 271065003375 active site 271065003376 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 271065003377 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 271065003378 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 271065003379 ZIP Zinc transporter; Region: Zip; pfam02535 271065003380 phosphoglucomutase; Region: PLN02307 271065003381 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 271065003382 active site 271065003383 substrate binding site [chemical binding]; other site 271065003384 metal binding site [ion binding]; metal-binding site 271065003385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 271065003386 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 271065003387 L,D-transpeptidase; Provisional; Region: PRK10260 271065003388 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 271065003389 putative peptidoglycan binding site; other site 271065003390 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 271065003391 Putative exonuclease, RdgC; Region: RdgC; cl01122 271065003392 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 271065003393 putative active site [active] 271065003394 Protein of unknown function (DUF615); Region: DUF615; cl01147 271065003395 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 271065003396 active site 271065003397 DNA polymerase IV; Validated; Region: PRK02406 271065003398 DNA binding site [nucleotide binding] 271065003399 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 271065003400 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; cl11978 271065003401 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 271065003402 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 271065003403 active site 271065003404 Int/Topo IB signature motif; other site 271065003405 GAF domain; Region: GAF; cl15785 271065003406 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 271065003407 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 271065003408 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 271065003409 diaminopimelate decarboxylase; Region: lysA; TIGR01048 271065003410 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 271065003411 active site 271065003412 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 271065003413 substrate binding site [chemical binding]; other site 271065003414 catalytic residues [active] 271065003415 dimer interface [polypeptide binding]; other site 271065003416 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 271065003417 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 271065003418 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 271065003419 DctM-like transporters; Region: DctM; pfam06808 271065003420 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 271065003421 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 271065003422 N-acetyl-D-glucosamine binding site [chemical binding]; other site 271065003423 catalytic residue [active] 271065003424 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 271065003425 active site 271065003426 NTP binding site [chemical binding]; other site 271065003427 metal binding triad [ion binding]; metal-binding site 271065003428 antibiotic binding site [chemical binding]; other site 271065003429 Peptidase family M23; Region: Peptidase_M23; pfam01551 271065003430 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 271065003431 hypothetical protein; Provisional; Region: PRK10557 271065003432 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 271065003433 Type II transport protein GspH; Region: GspH; pfam12019 271065003434 Type II transport protein GspH; Region: GspH; pfam12019 271065003435 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 271065003436 Transposase IS200 like; Region: Y1_Tnp; cl00848 271065003437 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 271065003438 putative active site [active] 271065003439 Haemagglutinin; Region: Hemagglutinin; pfam00509 271065003440 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 271065003441 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 271065003442 metal binding site [ion binding]; metal-binding site 271065003443 dimer interface [polypeptide binding]; other site 271065003444 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 271065003445 ArsC family; Region: ArsC; pfam03960 271065003446 putative catalytic residues [active] 271065003447 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 271065003448 putative active site [active] 271065003449 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 271065003450 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 271065003451 trimer interface [polypeptide binding]; other site 271065003452 active site 271065003453 substrate binding site [chemical binding]; other site 271065003454 CoA binding site [chemical binding]; other site 271065003455 succinyldiaminopimelate transaminase; Region: DapC_gpp; TIGR03538 271065003456 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271065003457 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271065003458 homodimer interface [polypeptide binding]; other site 271065003459 catalytic residue [active] 271065003460 Peptidase family M48; Region: Peptidase_M48; cl12018 271065003461 formylmethanofuran dehydrogenase subunit B; Region: one_C_dehyd_B; TIGR03129 271065003462 The MopB_FmdB-FwdB CD contains the molybdenum/tungsten formylmethanofuran dehydrogenases, subunit B (FmdB/FwdB), and other related proteins. Formylmethanofuran dehydrogenase catalyzes the first step in methane formation from CO2 in methanogenic archaea...; Region: MopB_FmdB-FwdB; cd02761 271065003463 putative [4Fe-4S] binding site [ion binding]; other site 271065003464 putative molybdopterin cofactor binding site [chemical binding]; other site 271065003465 formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121 271065003466 Formylmethanofuran dehydrogenase (FMDH) subunit A; Methanogenic bacteria and archea derive the energy for autotrophic growth from methanogenesis, the reduction of CO2 with molecular hydrogen as the electron donor. FMDH catalyzes the first step in...; Region: FMDH_A; cd01304 271065003467 active site 271065003468 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 271065003469 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 271065003470 Protein of unknown function (DUF433); Region: DUF433; cl01030 271065003471 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 271065003472 formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114 271065003473 Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913 271065003474 FTR, proximal lobe; Region: FTR_C; pfam02741 271065003475 FwdC/FmdC. This domain of unknown function is found in the subunit C of formylmethanofuran dehydrogenase, an enzyme that catalyzes the first step in methane formation from CO2 in methanogenic archaea, hyperthermophiles and bacteria. There are two...; Region: FwdC/FmdC; cd00980 271065003476 putative subunit interface; other site 271065003477 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 271065003478 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 271065003479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 271065003480 active site 271065003481 phosphorylation site [posttranslational modification] 271065003482 intermolecular recognition site; other site 271065003483 dimerization interface [polypeptide binding]; other site 271065003484 ANTAR domain; Region: ANTAR; cl04297 271065003485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271065003486 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 271065003487 putative substrate translocation pore; other site 271065003488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271065003489 nitrite reductase subunit NirD; Provisional; Region: PRK14989 271065003490 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271065003491 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 271065003492 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 271065003493 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 271065003494 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 271065003495 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 271065003496 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 271065003497 cyanate hydratase; Validated; Region: PRK02866 271065003498 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 271065003499 oligomer interface [polypeptide binding]; other site 271065003500 active site 271065003501 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 271065003502 active site 271065003503 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 271065003504 Catalytic domain of Protein Kinases; Region: PKc; cd00180 271065003505 active site 271065003506 ATP binding site [chemical binding]; other site 271065003507 substrate binding site [chemical binding]; other site 271065003508 activation loop (A-loop); other site 271065003509 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 271065003510 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 271065003511 Domain of unknown function (DUF389); Region: DUF389; cl00781 271065003512 TM2 domain; Region: TM2; cl00984 271065003513 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 271065003514 Ligand Binding Site [chemical binding]; other site 271065003515 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 271065003516 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 271065003517 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 271065003518 ABC transporter; Region: ABC_tran_2; pfam12848 271065003519 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 271065003520 YcxB-like protein; Region: YcxB; pfam14317 271065003521 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 271065003522 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271065003523 Transposase; Region: DEDD_Tnp_IS110; pfam01548 271065003524 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 271065003525 Response regulator receiver domain; Region: Response_reg; pfam00072 271065003526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065003527 active site 271065003528 phosphorylation site [posttranslational modification] 271065003529 intermolecular recognition site; other site 271065003530 dimerization interface [polypeptide binding]; other site 271065003531 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065003532 metal binding site [ion binding]; metal-binding site 271065003533 active site 271065003534 I-site; other site 271065003535 Predicted nucleotidyltransferase [General function prediction only]; Region: COG1665 271065003536 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 271065003537 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271065003538 motif II; other site 271065003539 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271065003540 ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660 271065003541 Putative D-pathway homolog; other site 271065003542 Low-spin heme binding site [chemical binding]; other site 271065003543 Subunit I/II interface [polypeptide binding]; other site 271065003544 Putative Q-pathway; other site 271065003545 Putative alternate electron transfer pathway; other site 271065003546 Putative water exit pathway; other site 271065003547 Binuclear center (active site) [active] 271065003548 Putative K-pathway homolog; other site 271065003549 Putative proton exit pathway; other site 271065003550 Subunit I/IIa interface [polypeptide binding]; other site 271065003551 Electron transfer pathway; other site 271065003552 Cytochrome c; Region: Cytochrom_C; cl11414 271065003553 Cytochrome c; Region: Cytochrom_C; cl11414 271065003554 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 271065003555 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 271065003556 ATP binding site [chemical binding]; other site 271065003557 substrate interface [chemical binding]; other site 271065003558 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 271065003559 oligomerisation interface [polypeptide binding]; other site 271065003560 mobile loop; other site 271065003561 roof hairpin; other site 271065003562 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 271065003563 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 271065003564 ring oligomerisation interface [polypeptide binding]; other site 271065003565 ATP/Mg binding site [chemical binding]; other site 271065003566 stacking interactions; other site 271065003567 hinge regions; other site 271065003568 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 271065003569 Protein required for attachment to host cells; Region: Host_attach; cl02398 271065003570 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 271065003571 Integrase core domain; Region: rve; cl01316 271065003572 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065003573 Walker A motif; other site 271065003574 ATP binding site [chemical binding]; other site 271065003575 Walker B motif; other site 271065003576 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 271065003577 Transposase; Region: DDE_Tnp_ISL3; pfam01610 271065003578 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 271065003579 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 271065003580 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 271065003581 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 271065003582 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 271065003583 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 271065003584 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 271065003585 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 271065003586 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 271065003587 SLBB domain; Region: SLBB; pfam10531 271065003588 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 271065003589 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 271065003590 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271065003591 ligand binding site [chemical binding]; other site 271065003592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 271065003593 ERG2 and Sigma1 receptor like protein; Region: ERG2_Sigma1R; pfam04622 271065003594 Phospholipid methyltransferase; Region: PEMT; cl00763 271065003595 Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; cl11574 271065003596 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 271065003597 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271065003598 Radical SAM superfamily; Region: Radical_SAM; pfam04055 271065003599 FeS/SAM binding site; other site 271065003600 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 271065003601 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 271065003602 dimer interface [polypeptide binding]; other site 271065003603 putative functional site; other site 271065003604 putative MPT binding site; other site 271065003605 Cytochrome c [Energy production and conversion]; Region: COG3258 271065003606 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 271065003607 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 271065003608 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 271065003609 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 271065003610 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 271065003611 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 271065003612 TPP-binding site; other site 271065003613 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 271065003614 PYR/PP interface [polypeptide binding]; other site 271065003615 dimer interface [polypeptide binding]; other site 271065003616 TPP binding site [chemical binding]; other site 271065003617 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 271065003618 Copper resistance protein D; Region: CopD; cl00563 271065003619 Bacterial Ig-like domain; Region: Big_5; cl01012 271065003620 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 271065003621 Protein export membrane protein; Region: SecD_SecF; cl14618 271065003622 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 271065003623 Helix-turn-helix domains; Region: HTH; cl00088 271065003624 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 271065003625 Sulfate transporter family; Region: Sulfate_transp; cl15842 271065003626 Sulfate transporter family; Region: Sulfate_transp; cl15842 271065003627 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 271065003628 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 271065003629 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 271065003630 Ligand Binding Site [chemical binding]; other site 271065003631 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 271065003632 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 271065003633 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 271065003634 inhibitor-cofactor binding pocket; inhibition site 271065003635 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271065003636 catalytic residue [active] 271065003637 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 271065003638 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065003639 NAD(P) binding site [chemical binding]; other site 271065003640 active site 271065003641 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 271065003642 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 271065003643 P-loop; other site 271065003644 Magnesium ion binding site [ion binding]; other site 271065003645 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 271065003646 Magnesium ion binding site [ion binding]; other site 271065003647 Uncharacterized conserved protein [Function unknown]; Region: COG3025 271065003648 CHAD domain; Region: CHAD; cl10506 271065003649 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 271065003650 catalytic core [active] 271065003651 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271065003652 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 271065003653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271065003654 dimer interface [polypeptide binding]; other site 271065003655 conserved gate region; other site 271065003656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271065003657 dimer interface [polypeptide binding]; other site 271065003658 conserved gate region; other site 271065003659 putative PBP binding loops; other site 271065003660 ABC-ATPase subunit interface; other site 271065003661 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 271065003662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271065003663 dimer interface [polypeptide binding]; other site 271065003664 conserved gate region; other site 271065003665 putative PBP binding loops; other site 271065003666 ABC-ATPase subunit interface; other site 271065003667 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 271065003668 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 271065003669 Walker A/P-loop; other site 271065003670 ATP binding site [chemical binding]; other site 271065003671 Q-loop/lid; other site 271065003672 ABC transporter signature motif; other site 271065003673 Walker B; other site 271065003674 D-loop; other site 271065003675 H-loop/switch region; other site 271065003676 transcriptional regulator PhoU; Provisional; Region: PRK11115 271065003677 PhoU domain; Region: PhoU; pfam01895 271065003678 PhoU domain; Region: PhoU; pfam01895 271065003679 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 271065003680 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271065003681 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 271065003682 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 271065003683 Predicted transcriptional regulator [Transcription]; Region: COG2378 271065003684 WYL domain; Region: WYL; cl14852 271065003685 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 271065003686 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 271065003687 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065003688 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 271065003689 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 271065003690 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 271065003691 CRISPR-associated protein Cas8c/Csd1, subtype I-C/DVULG; Region: cas_Csd1; TIGR01863 271065003692 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 271065003693 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 271065003694 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 271065003695 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 271065003696 L,D-transpeptidase; Provisional; Region: PRK10260 271065003697 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 271065003698 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 271065003699 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 271065003700 active site 271065003701 substrate binding site [chemical binding]; other site 271065003702 cosubstrate binding site; other site 271065003703 catalytic site [active] 271065003704 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 271065003705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065003706 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271065003707 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 271065003708 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 271065003709 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 271065003710 E3 interaction surface; other site 271065003711 lipoyl attachment site [posttranslational modification]; other site 271065003712 e3 binding domain; Region: E3_binding; pfam02817 271065003713 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 271065003714 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 271065003715 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 271065003716 dimer interface [polypeptide binding]; other site 271065003717 TPP-binding site [chemical binding]; other site 271065003718 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 271065003719 dimer interface [polypeptide binding]; other site 271065003720 Citrate synthase; Region: Citrate_synt; pfam00285 271065003721 active site 271065003722 citrylCoA binding site [chemical binding]; other site 271065003723 NADH binding [chemical binding]; other site 271065003724 cationic pore residues; other site 271065003725 oxalacetate/citrate binding site [chemical binding]; other site 271065003726 coenzyme A binding site [chemical binding]; other site 271065003727 catalytic triad [active] 271065003728 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 271065003729 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 271065003730 active site 271065003731 intersubunit interface [polypeptide binding]; other site 271065003732 catalytic residue [active] 271065003733 Dehydratase family; Region: ILVD_EDD; cl00340 271065003734 6-phosphogluconate dehydratase; Region: edd; TIGR01196 271065003735 AIR carboxylase; Region: AIRC; cl00310 271065003736 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 271065003737 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271065003738 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 271065003739 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 271065003740 active site 271065003741 flagellar motor protein MotD; Reviewed; Region: PRK09038 271065003742 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271065003743 ligand binding site [chemical binding]; other site 271065003744 flagellar motor protein MotP; Reviewed; Region: PRK06926 271065003745 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 271065003746 response regulator; Provisional; Region: PRK09483 271065003747 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065003748 active site 271065003749 phosphorylation site [posttranslational modification] 271065003750 intermolecular recognition site; other site 271065003751 dimerization interface [polypeptide binding]; other site 271065003752 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271065003753 DNA binding residues [nucleotide binding] 271065003754 dimerization interface [polypeptide binding]; other site 271065003755 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 271065003756 NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078 271065003757 NADP binding site [chemical binding]; other site 271065003758 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 271065003759 NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078 271065003760 NADP binding site [chemical binding]; other site 271065003761 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 271065003762 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 271065003763 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 271065003764 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 271065003765 catalytic residue [active] 271065003766 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 271065003767 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 271065003768 putative NAD(P) binding site [chemical binding]; other site 271065003769 HDOD domain; Region: HDOD; pfam08668 271065003770 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 271065003771 Zn2+ binding site [ion binding]; other site 271065003772 Mg2+ binding site [ion binding]; other site 271065003773 hypothetical protein; Provisional; Region: PRK00106 271065003774 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 271065003775 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065003776 metal binding site [ion binding]; metal-binding site 271065003777 active site 271065003778 I-site; other site 271065003779 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065003780 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 271065003781 Transglycosylase; Region: Transgly; cl07896 271065003782 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 271065003783 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 271065003784 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 271065003785 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 271065003786 Cupin domain; Region: Cupin_2; cl09118 271065003787 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271065003788 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271065003789 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 271065003790 mercuric reductase; Validated; Region: PRK06370 271065003791 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065003792 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271065003793 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 271065003794 Methyltransferase domain; Region: Methyltransf_31; pfam13847 271065003795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065003796 S-adenosylmethionine binding site [chemical binding]; other site 271065003797 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 271065003798 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 271065003799 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271065003800 FeS/SAM binding site; other site 271065003801 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 271065003802 HsdM N-terminal domain; Region: HsdM_N; pfam12161 271065003803 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 271065003804 Abi-like protein; Region: Abi_2; cl01988 271065003805 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 271065003806 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 271065003807 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 271065003808 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271065003809 non-specific DNA binding site [nucleotide binding]; other site 271065003810 salt bridge; other site 271065003811 sequence-specific DNA binding site [nucleotide binding]; other site 271065003812 potential frameshift: common BLAST hit: gi|310830284|ref|YP_003965384.1| type I restriction-modification system endonuclease 271065003813 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 271065003814 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 271065003815 potential frameshift: common BLAST hit: gi|110681178|ref|YP_684185.1| type I restriction-modification system endonuclease 271065003816 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 271065003817 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065003818 ATP binding site [chemical binding]; other site 271065003819 putative Mg++ binding site [ion binding]; other site 271065003820 potential frameshift: common BLAST hit: gi|110681178|ref|YP_684185.1| type I restriction-modification system endonuclease 271065003821 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 271065003822 His-Xaa-Ser system putative quinone modification maturase; Region: SAM_quin_mod; TIGR03981 271065003823 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 271065003824 substrate pocket [chemical binding]; other site 271065003825 active site 271065003826 proteolytic cleavage site; other site 271065003827 dimer interface [polypeptide binding]; other site 271065003828 Sel1 repeat; Region: Sel1; cl02723 271065003829 RNA polymerase sigma factor; Provisional; Region: PRK12515 271065003830 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271065003831 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 271065003832 DNA binding residues [nucleotide binding] 271065003833 CHASE2 domain; Region: CHASE2; cl01732 271065003834 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 271065003835 Peptidase family M48; Region: Peptidase_M48; cl12018 271065003836 Predicted transcriptional regulator [Transcription]; Region: COG2345 271065003837 Helix-turn-helix domains; Region: HTH; cl00088 271065003838 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 271065003839 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 271065003840 FAD binding pocket [chemical binding]; other site 271065003841 conserved FAD binding motif [chemical binding]; other site 271065003842 phosphate binding motif [ion binding]; other site 271065003843 beta-alpha-beta structure motif; other site 271065003844 NAD binding pocket [chemical binding]; other site 271065003845 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 271065003846 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 271065003847 active site 271065003848 metal binding site [ion binding]; metal-binding site 271065003849 ribonuclease R; Region: RNase_R; TIGR02063 271065003850 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 271065003851 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 271065003852 RNB domain; Region: RNB; pfam00773 271065003853 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 271065003854 RNA binding site [nucleotide binding]; other site 271065003855 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 271065003856 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 271065003857 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 271065003858 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 271065003859 Sel1 repeat; Region: Sel1; cl02723 271065003860 Sel1 repeat; Region: Sel1; cl02723 271065003861 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 271065003862 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 271065003863 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 271065003864 Sel1 repeat; Region: Sel1; cl02723 271065003865 Sel1 repeat; Region: Sel1; cl02723 271065003866 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 271065003867 N-acetyl-D-glucosamine binding site [chemical binding]; other site 271065003868 catalytic residue [active] 271065003869 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 271065003870 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 271065003871 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 271065003872 CAP-like domain; other site 271065003873 active site 271065003874 primary dimer interface [polypeptide binding]; other site 271065003875 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 271065003876 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 271065003877 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 271065003878 homodimer interface [polypeptide binding]; other site 271065003879 NADP binding site [chemical binding]; other site 271065003880 substrate binding site [chemical binding]; other site 271065003881 PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915 271065003882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065003883 active site 271065003884 phosphorylation site [posttranslational modification] 271065003885 intermolecular recognition site; other site 271065003886 dimerization interface [polypeptide binding]; other site 271065003887 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065003888 Walker A motif; other site 271065003889 ATP binding site [chemical binding]; other site 271065003890 Walker B motif; other site 271065003891 arginine finger; other site 271065003892 Helix-turn-helix domains; Region: HTH; cl00088 271065003893 putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916 271065003894 GAF domain; Region: GAF; cl15785 271065003895 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065003896 dimer interface [polypeptide binding]; other site 271065003897 phosphorylation site [posttranslational modification] 271065003898 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065003899 ATP binding site [chemical binding]; other site 271065003900 Mg2+ binding site [ion binding]; other site 271065003901 G-X-G motif; other site 271065003902 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 271065003903 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271065003904 TPR motif; other site 271065003905 binding surface 271065003906 tetratricopeptide repeat protein; Provisional; Region: PRK11788 271065003907 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271065003908 binding surface 271065003909 TPR motif; other site 271065003910 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271065003911 binding surface 271065003912 TPR motif; other site 271065003913 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 271065003914 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271065003915 binding surface 271065003916 TPR motif; other site 271065003917 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271065003918 TPR motif; other site 271065003919 TPR repeat; Region: TPR_11; pfam13414 271065003920 binding surface 271065003921 TPR repeat; Region: TPR_11; pfam13414 271065003922 Integrase core domain; Region: rve; cl01316 271065003923 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 271065003924 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 271065003925 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 271065003926 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 271065003927 Chain length determinant protein; Region: Wzz; cl15801 271065003928 exopolysaccharide/PEPCTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 271065003929 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065003930 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065003931 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; cl12051 271065003932 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 271065003933 polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 271065003934 putative active site [active] 271065003935 putative catalytic site [active] 271065003936 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271065003937 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 271065003938 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 271065003939 Domain of unknown function DUF21; Region: DUF21; pfam01595 271065003940 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 271065003941 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 271065003942 FAD binding pocket [chemical binding]; other site 271065003943 FAD binding motif [chemical binding]; other site 271065003944 phosphate binding motif [ion binding]; other site 271065003945 beta-alpha-beta structure motif; other site 271065003946 NAD binding pocket [chemical binding]; other site 271065003947 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 271065003948 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 271065003949 XdhC Rossmann domain; Region: XdhC_C; pfam13478 271065003950 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 271065003951 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 271065003952 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 271065003953 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 271065003954 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 271065003955 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 271065003956 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 271065003957 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 271065003958 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 271065003959 active site 271065003960 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 271065003961 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 271065003962 Mechanosensitive ion channel; Region: MS_channel; pfam00924 271065003963 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 271065003964 Response regulator receiver domain; Region: Response_reg; pfam00072 271065003965 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065003966 active site 271065003967 phosphorylation site [posttranslational modification] 271065003968 intermolecular recognition site; other site 271065003969 dimerization interface [polypeptide binding]; other site 271065003970 sensory histidine kinase AtoS; Provisional; Region: PRK11360 271065003971 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065003972 ATP binding site [chemical binding]; other site 271065003973 Mg2+ binding site [ion binding]; other site 271065003974 G-X-G motif; other site 271065003975 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 271065003976 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 271065003977 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 271065003978 B12 binding site [chemical binding]; other site 271065003979 methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463 271065003980 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 271065003981 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 271065003982 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 271065003983 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065003984 dimer interface [polypeptide binding]; other site 271065003985 phosphorylation site [posttranslational modification] 271065003986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065003987 ATP binding site [chemical binding]; other site 271065003988 Mg2+ binding site [ion binding]; other site 271065003989 G-X-G motif; other site 271065003990 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 271065003991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065003992 active site 271065003993 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 271065003994 phosphorylation site [posttranslational modification] 271065003995 intermolecular recognition site; other site 271065003996 dimerization interface [polypeptide binding]; other site 271065003997 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065003998 putative active site [active] 271065003999 heme pocket [chemical binding]; other site 271065004000 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065004001 metal binding site [ion binding]; metal-binding site 271065004002 active site 271065004003 I-site; other site 271065004004 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065004005 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 271065004006 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 271065004007 inhibitor-cofactor binding pocket; inhibition site 271065004008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271065004009 catalytic residue [active] 271065004010 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 271065004011 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 271065004012 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 271065004013 protein binding site [polypeptide binding]; other site 271065004014 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 271065004015 protein binding site [polypeptide binding]; other site 271065004016 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 271065004017 Predicted transporter component [General function prediction only]; Region: COG2391 271065004018 Predicted transporter component [General function prediction only]; Region: COG2391 271065004019 Sulphur transport; Region: Sulf_transp; cl01018 271065004020 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 271065004021 Moco binding site; other site 271065004022 metal coordination site [ion binding]; other site 271065004023 Cytochrome c; Region: Cytochrom_C; cl11414 271065004024 Response regulator receiver domain; Region: Response_reg; pfam00072 271065004025 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065004026 active site 271065004027 phosphorylation site [posttranslational modification] 271065004028 intermolecular recognition site; other site 271065004029 dimerization interface [polypeptide binding]; other site 271065004030 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 271065004031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065004032 active site 271065004033 phosphorylation site [posttranslational modification] 271065004034 intermolecular recognition site; other site 271065004035 dimerization interface [polypeptide binding]; other site 271065004036 Formaldehyde-activating enzyme (Fae); Region: Fae; cl00774 271065004037 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271065004038 FeS/SAM binding site; other site 271065004039 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 271065004040 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 271065004041 Ligand Binding Site [chemical binding]; other site 271065004042 TilS substrate binding domain; Region: TilS; pfam09179 271065004043 B3/4 domain; Region: B3_4; cl11458 271065004044 CTP synthetase; Validated; Region: pyrG; PRK05380 271065004045 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 271065004046 Catalytic site [active] 271065004047 active site 271065004048 UTP binding site [chemical binding]; other site 271065004049 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 271065004050 active site 271065004051 putative oxyanion hole; other site 271065004052 catalytic triad [active] 271065004053 NeuB family; Region: NeuB; cl00496 271065004054 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 271065004055 enolase; Provisional; Region: eno; PRK00077 271065004056 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 271065004057 dimer interface [polypeptide binding]; other site 271065004058 metal binding site [ion binding]; metal-binding site 271065004059 substrate binding pocket [chemical binding]; other site 271065004060 Septum formation initiator; Region: DivIC; cl11433 271065004061 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 271065004062 substrate binding site; other site 271065004063 dimer interface; other site 271065004064 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 271065004065 homotrimer interaction site [polypeptide binding]; other site 271065004066 zinc binding site [ion binding]; other site 271065004067 CDP-binding sites; other site 271065004068 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 271065004069 PseudoU_synth_EcTruD: Pseudouridine synthase, TruD family. This group consists of bacterial pseudouridine synthases similar to Escherichia coli TruD. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_EcTruD; cd02575 271065004070 Permutation of conserved domain; other site 271065004071 active site 271065004072 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cd01291 271065004073 Bacitracin resistance protein BacA; Region: BacA; cl00858 271065004074 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 271065004075 Smr domain; Region: Smr; cl02619 271065004076 Survival protein SurE; Region: SurE; cl00448 271065004077 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 271065004078 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065004079 S-adenosylmethionine binding site [chemical binding]; other site 271065004080 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 271065004081 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 271065004082 tetramer (dimer of dimers) interface [polypeptide binding]; other site 271065004083 active site 271065004084 dimer interface [polypeptide binding]; other site 271065004085 Transposase; Region: DEDD_Tnp_IS110; pfam01548 271065004086 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 271065004087 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 271065004088 dimer interface [polypeptide binding]; other site 271065004089 [2Fe-2S] cluster binding site [ion binding]; other site 271065004090 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 271065004091 DEAD-like helicases superfamily; Region: DEXDc; smart00487 271065004092 ATP binding site [chemical binding]; other site 271065004093 Mg++ binding site [ion binding]; other site 271065004094 motif III; other site 271065004095 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271065004096 nucleotide binding region [chemical binding]; other site 271065004097 ATP-binding site [chemical binding]; other site 271065004098 intramembrane serine protease GlpG; Provisional; Region: PRK10907 271065004099 Rhomboid family; Region: Rhomboid; cl11446 271065004100 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 271065004101 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 271065004102 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 271065004103 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 271065004104 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 271065004105 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 271065004106 active site 271065004107 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 271065004108 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 271065004109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271065004110 catalytic residue [active] 271065004111 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 271065004112 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 271065004113 substrate binding site [chemical binding]; other site 271065004114 active site 271065004115 catalytic residues [active] 271065004116 heterodimer interface [polypeptide binding]; other site 271065004117 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 271065004118 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 271065004119 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 271065004120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 271065004121 Sporulation related domain; Region: SPOR; cl10051 271065004122 Sporulation related domain; Region: SPOR; cl10051 271065004123 Colicin V production protein; Region: Colicin_V; cl00567 271065004124 amidophosphoribosyltransferase; Provisional; Region: PRK09246 271065004125 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 271065004126 active site 271065004127 tetramer interface [polypeptide binding]; other site 271065004128 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 271065004129 active site 271065004130 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 271065004131 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 271065004132 homodimer interface [polypeptide binding]; other site 271065004133 substrate-cofactor binding pocket; other site 271065004134 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271065004135 catalytic residue [active] 271065004136 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 271065004137 putative hydrophobic ligand binding site [chemical binding]; other site 271065004138 protein interface [polypeptide binding]; other site 271065004139 gate; other site 271065004140 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 271065004141 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 271065004142 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 271065004143 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 271065004144 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 271065004145 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 271065004146 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 271065004147 Domain of unknown function DUF59; Region: DUF59; cl00941 271065004148 short chain dehydrogenase; Provisional; Region: PRK06138 271065004149 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065004150 NAD(P) binding site [chemical binding]; other site 271065004151 active site 271065004152 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271065004153 phosphoglycolate phosphatase; Provisional; Region: PRK13222 271065004154 motif I; other site 271065004155 active site 271065004156 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271065004157 motif II; other site 271065004158 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 271065004159 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065004160 S-adenosylmethionine binding site [chemical binding]; other site 271065004161 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 271065004162 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 271065004163 active site 271065004164 putative substrate binding pocket [chemical binding]; other site 271065004165 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 271065004166 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 271065004167 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 271065004168 NMT1-like family; Region: NMT1_2; cl15260 271065004169 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 271065004170 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271065004171 PAS domain; Region: PAS_9; pfam13426 271065004172 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271065004173 PAS domain; Region: PAS_9; pfam13426 271065004174 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 271065004175 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065004176 PAS fold; Region: PAS_3; pfam08447 271065004177 putative active site [active] 271065004178 heme pocket [chemical binding]; other site 271065004179 GAF domain; Region: GAF_2; pfam13185 271065004180 GAF domain; Region: GAF; cl15785 271065004181 PAS domain S-box; Region: sensory_box; TIGR00229 271065004182 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065004183 putative active site [active] 271065004184 heme pocket [chemical binding]; other site 271065004185 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 271065004186 Zn2+ binding site [ion binding]; other site 271065004187 Mg2+ binding site [ion binding]; other site 271065004188 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 271065004189 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 271065004190 active site 271065004191 catalytic site [active] 271065004192 tartrate dehydrogenase; Provisional; Region: PRK08194 271065004193 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 271065004194 (R)-citramalate synthase; Provisional; Region: PRK09389 271065004195 Leptospira interrogans citramalate synthase (CMS) and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_CMS; cd07945 271065004196 active site 271065004197 catalytic residues [active] 271065004198 metal binding site [ion binding]; metal-binding site 271065004199 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 271065004200 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 271065004201 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 271065004202 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 271065004203 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065004204 putative active site [active] 271065004205 heme pocket [chemical binding]; other site 271065004206 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065004207 dimer interface [polypeptide binding]; other site 271065004208 phosphorylation site [posttranslational modification] 271065004209 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065004210 ATP binding site [chemical binding]; other site 271065004211 Mg2+ binding site [ion binding]; other site 271065004212 G-X-G motif; other site 271065004213 Response regulator receiver domain; Region: Response_reg; pfam00072 271065004214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065004215 active site 271065004216 phosphorylation site [posttranslational modification] 271065004217 intermolecular recognition site; other site 271065004218 dimerization interface [polypeptide binding]; other site 271065004219 Response regulator receiver domain; Region: Response_reg; pfam00072 271065004220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065004221 active site 271065004222 phosphorylation site [posttranslational modification] 271065004223 intermolecular recognition site; other site 271065004224 dimerization interface [polypeptide binding]; other site 271065004225 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 271065004226 siroheme synthase; Provisional; Region: cysG; PRK10637 271065004227 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065004228 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 271065004229 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 271065004230 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 271065004231 dimer interface [polypeptide binding]; other site 271065004232 [2Fe-2S] cluster binding site [ion binding]; other site 271065004233 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 271065004234 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 271065004235 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 271065004236 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 271065004237 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 271065004238 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 271065004239 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 271065004240 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 271065004241 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 271065004242 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 271065004243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065004244 S-adenosylmethionine binding site [chemical binding]; other site 271065004245 CbiD; Region: CbiD; cl00828 271065004246 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 271065004247 Precorrin-8X methylmutase; Region: CbiC; pfam02570 271065004248 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 271065004249 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 271065004250 putative active site [active] 271065004251 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 271065004252 putative active site [active] 271065004253 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 271065004254 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 271065004255 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 271065004256 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065004257 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 271065004258 catalytic triad [active] 271065004259 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 271065004260 acyl-CoA synthetase; Validated; Region: PRK05850 271065004261 AMP-binding enzyme; Region: AMP-binding; cl15778 271065004262 peptide synthase; Provisional; Region: PRK12316 271065004263 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271065004264 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 271065004265 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 271065004266 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 271065004267 AMP-binding enzyme; Region: AMP-binding; cl15778 271065004268 AMP-binding enzyme; Region: AMP-binding; cl15778 271065004269 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271065004270 Condensation domain; Region: Condensation; pfam00668 271065004271 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 271065004272 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 271065004273 AMP-binding enzyme; Region: AMP-binding; cl15778 271065004274 acyl-CoA synthetase; Validated; Region: PRK08308 271065004275 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271065004276 peptide synthase; Provisional; Region: PRK12467 271065004277 AMP-binding enzyme; Region: AMP-binding; cl15778 271065004278 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271065004279 thioester reductase domain; Region: Thioester-redct; TIGR01746 271065004280 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 271065004281 putative NAD(P) binding site [chemical binding]; other site 271065004282 active site 271065004283 putative substrate binding site [chemical binding]; other site 271065004284 Secretin and TonB N terminus short domain; Region: STN; cl06624 271065004285 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 271065004286 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 271065004287 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 271065004288 N-terminal plug; other site 271065004289 ligand-binding site [chemical binding]; other site 271065004290 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 271065004291 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 271065004292 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 271065004293 JmjC domain, hydroxylase; Region: JmjC; cl15814 271065004294 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 271065004295 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 271065004296 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 271065004297 Predicted transcriptional regulator [Transcription]; Region: COG4190 271065004298 Helix-turn-helix domains; Region: HTH; cl00088 271065004299 MbtH-like protein; Region: MbtH; cl01279 271065004300 RNA polymerase sigma factor; Provisional; Region: PRK12528 271065004301 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271065004302 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 271065004303 DNA binding residues [nucleotide binding] 271065004304 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 271065004305 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 271065004306 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 271065004307 Walker A/P-loop; other site 271065004308 ATP binding site [chemical binding]; other site 271065004309 Q-loop/lid; other site 271065004310 ABC transporter signature motif; other site 271065004311 Walker B; other site 271065004312 D-loop; other site 271065004313 H-loop/switch region; other site 271065004314 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 271065004315 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 271065004316 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 271065004317 active site 271065004318 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 271065004319 FecR protein; Region: FecR; pfam04773 271065004320 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 271065004321 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 271065004322 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 271065004323 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271065004324 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 271065004325 Protein export membrane protein; Region: SecD_SecF; cl14618 271065004326 Gram-negative bacterial tonB protein; Region: TonB; cl10048 271065004327 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 271065004328 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 271065004329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271065004330 Major Facilitator Superfamily; Region: MFS_1; pfam07690 271065004331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271065004332 HDOD domain; Region: HDOD; pfam08668 271065004333 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 271065004334 HemK family putative methylases; Region: hemK_fam; TIGR00536 271065004335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065004336 S-adenosylmethionine binding site [chemical binding]; other site 271065004337 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 271065004338 Tetramer interface [polypeptide binding]; other site 271065004339 active site 271065004340 FMN-binding site [chemical binding]; other site 271065004341 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 271065004342 MFS_1 like family; Region: MFS_1_like; pfam12832 271065004343 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 271065004344 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 271065004345 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 271065004346 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 271065004347 Trm112p-like protein; Region: Trm112p; cl01066 271065004348 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 271065004349 Ligand binding site; other site 271065004350 oligomer interface; other site 271065004351 aminotransferase; Validated; Region: PRK08175 271065004352 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271065004353 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271065004354 homodimer interface [polypeptide binding]; other site 271065004355 catalytic residue [active] 271065004356 homoserine dehydrogenase; Provisional; Region: PRK06349 271065004357 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065004358 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 271065004359 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 271065004360 threonine synthase; Reviewed; Region: PRK06721 271065004361 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 271065004362 homodimer interface [polypeptide binding]; other site 271065004363 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271065004364 catalytic residue [active] 271065004365 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 271065004366 DHH family; Region: DHH; pfam01368 271065004367 DHHA1 domain; Region: DHHA1; pfam02272 271065004368 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 271065004369 Zn2+ binding site [ion binding]; other site 271065004370 Mg2+ binding site [ion binding]; other site 271065004371 putative carbohydrate kinase; Provisional; Region: PRK10565 271065004372 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 271065004373 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 271065004374 putative substrate binding site [chemical binding]; other site 271065004375 putative ATP binding site [chemical binding]; other site 271065004376 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 271065004377 AMIN domain; Region: AMIN; pfam11741 271065004378 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 271065004379 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 271065004380 active site 271065004381 metal binding site [ion binding]; metal-binding site 271065004382 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 271065004383 putative peptidoglycan binding site; other site 271065004384 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 271065004385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065004386 ATP binding site [chemical binding]; other site 271065004387 Mg2+ binding site [ion binding]; other site 271065004388 G-X-G motif; other site 271065004389 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 271065004390 ATP binding site [chemical binding]; other site 271065004391 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 271065004392 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 271065004393 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065004394 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776 271065004395 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 271065004396 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 271065004397 GTP/Mg2+ binding site [chemical binding]; other site 271065004398 G4 box; other site 271065004399 G5 box; other site 271065004400 G1 box; other site 271065004401 Switch I region; other site 271065004402 G2 box; other site 271065004403 G3 box; other site 271065004404 Switch II region; other site 271065004405 Uncharacterized conserved protein [Function unknown]; Region: COG1739 271065004406 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 271065004407 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 271065004408 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 271065004409 YcfA-like protein; Region: YcfA; cl00752 271065004410 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 271065004411 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 271065004412 NAD(P) binding site [chemical binding]; other site 271065004413 catalytic residues [active] 271065004414 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 271065004415 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271065004416 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 271065004417 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 271065004418 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 271065004419 E3 interaction surface; other site 271065004420 lipoyl attachment site [posttranslational modification]; other site 271065004421 e3 binding domain; Region: E3_binding; pfam02817 271065004422 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 271065004423 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 271065004424 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 271065004425 TPP-binding site [chemical binding]; other site 271065004426 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 271065004427 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 271065004428 H-NS histone family; Region: Histone_HNS; pfam00816 271065004429 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 271065004430 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 271065004431 active site residue [active] 271065004432 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 271065004433 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 271065004434 dimer interface [polypeptide binding]; other site 271065004435 putative functional site; other site 271065004436 putative MPT binding site; other site 271065004437 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 271065004438 Walker A motif; other site 271065004439 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 271065004440 HSP70 interaction site [polypeptide binding]; other site 271065004441 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 271065004442 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 271065004443 putative peptidoglycan binding site; other site 271065004444 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 271065004445 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 271065004446 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271065004447 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 271065004448 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 271065004449 DNA binding residues [nucleotide binding] 271065004450 Predicted amidohydrolase [General function prediction only]; Region: COG0388 271065004451 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 271065004452 putative active site [active] 271065004453 catalytic triad [active] 271065004454 putative dimer interface [polypeptide binding]; other site 271065004455 VanZ like family; Region: VanZ; cl01971 271065004456 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 271065004457 dinuclear metal binding motif [ion binding]; other site 271065004458 NnrS protein; Region: NnrS; cl01258 271065004459 hypothetical protein; Provisional; Region: PRK11281 271065004460 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 271065004461 Mechanosensitive ion channel; Region: MS_channel; pfam00924 271065004462 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 271065004463 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 271065004464 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 271065004465 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 271065004466 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 271065004467 active site 271065004468 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 271065004469 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271065004470 active site 271065004471 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 271065004472 Acyl transferase domain; Region: Acyl_transf_1; cl08282 271065004473 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 271065004474 putative NADP binding site [chemical binding]; other site 271065004475 active site 271065004476 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 271065004477 Family description; Region: VCBS; pfam13517 271065004478 FG-GAP repeat; Region: FG-GAP; cl15299 271065004479 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 271065004480 Protein of unknown function (DUF1702); Region: DUF1702; pfam08012 271065004481 PEP-CTERM motif; Region: VPEP; cl15443 271065004482 Helix-turn-helix domains; Region: HTH; cl00088 271065004483 Winged helix-turn helix; Region: HTH_29; pfam13551 271065004484 Helix-turn-helix domains; Region: HTH; cl00088 271065004485 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 271065004486 Protein export membrane protein; Region: SecD_SecF; cl14618 271065004487 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 271065004488 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 271065004489 DNA binding site [nucleotide binding] 271065004490 catalytic residue [active] 271065004491 H2TH interface [polypeptide binding]; other site 271065004492 putative catalytic residues [active] 271065004493 turnover-facilitating residue; other site 271065004494 intercalation triad [nucleotide binding]; other site 271065004495 8OG recognition residue [nucleotide binding]; other site 271065004496 putative reading head residues; other site 271065004497 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 271065004498 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 271065004499 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 271065004500 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 271065004501 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225 271065004502 ABC-2 type transporter; Region: ABC2_membrane; cl11417 271065004503 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 271065004504 transmembrane helices; other site 271065004505 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 271065004506 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 271065004507 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 271065004508 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 271065004509 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 271065004510 Walker A/P-loop; other site 271065004511 ATP binding site [chemical binding]; other site 271065004512 Q-loop/lid; other site 271065004513 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 271065004514 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 271065004515 Q-loop/lid; other site 271065004516 ABC transporter signature motif; other site 271065004517 Walker B; other site 271065004518 D-loop; other site 271065004519 H-loop/switch region; other site 271065004520 Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115 271065004521 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 271065004522 FtsZ protein binding site [polypeptide binding]; other site 271065004523 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 271065004524 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 271065004525 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 271065004526 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271065004527 catalytic residue [active] 271065004528 Methyltransferase domain; Region: Methyltransf_31; pfam13847 271065004529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065004530 S-adenosylmethionine binding site [chemical binding]; other site 271065004531 polyphosphate kinase; Provisional; Region: PRK05443 271065004532 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 271065004533 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 271065004534 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 271065004535 putative active site [active] 271065004536 catalytic site [active] 271065004537 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 271065004538 putative domain interface [polypeptide binding]; other site 271065004539 putative active site [active] 271065004540 catalytic site [active] 271065004541 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 271065004542 dihydropteroate synthase; Region: DHPS; TIGR01496 271065004543 substrate binding pocket [chemical binding]; other site 271065004544 dimer interface [polypeptide binding]; other site 271065004545 inhibitor binding site; inhibition site 271065004546 Archaeal flavoproteins [Energy production and conversion]; Region: COG1036 271065004547 Flavoprotein; Region: Flavoprotein; cl08021 271065004548 dihydropteroate synthase-related protein; Region: TIGR00284 271065004549 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 271065004550 substrate binding pocket [chemical binding]; other site 271065004551 dimer interface [polypeptide binding]; other site 271065004552 inhibitor binding site; inhibition site 271065004553 Flavin Reductases; Region: FlaRed; cl00801 271065004554 Protein of unknown function (DUF556); Region: DUF556; cl00822 271065004555 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 271065004556 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 271065004557 Sulfatase; Region: Sulfatase; cl10460 271065004558 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 271065004559 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 271065004560 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 271065004561 nucleotide binding pocket [chemical binding]; other site 271065004562 K-X-D-G motif; other site 271065004563 catalytic site [active] 271065004564 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 271065004565 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 271065004566 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 271065004567 Dimer interface [polypeptide binding]; other site 271065004568 BRCT sequence motif; other site 271065004569 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 271065004570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065004571 active site 271065004572 phosphorylation site [posttranslational modification] 271065004573 intermolecular recognition site; other site 271065004574 dimerization interface [polypeptide binding]; other site 271065004575 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 271065004576 Zn2+ binding site [ion binding]; other site 271065004577 Mg2+ binding site [ion binding]; other site 271065004578 PAS fold; Region: PAS_4; pfam08448 271065004579 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065004580 putative active site [active] 271065004581 heme pocket [chemical binding]; other site 271065004582 PAS domain S-box; Region: sensory_box; TIGR00229 271065004583 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271065004584 PAS domain S-box; Region: sensory_box; TIGR00229 271065004585 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065004586 putative active site [active] 271065004587 heme pocket [chemical binding]; other site 271065004588 PAS fold; Region: PAS_4; pfam08448 271065004589 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065004590 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 271065004591 putative active site [active] 271065004592 heme pocket [chemical binding]; other site 271065004593 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065004594 dimer interface [polypeptide binding]; other site 271065004595 phosphorylation site [posttranslational modification] 271065004596 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065004597 ATP binding site [chemical binding]; other site 271065004598 Mg2+ binding site [ion binding]; other site 271065004599 G-X-G motif; other site 271065004600 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 271065004601 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065004602 active site 271065004603 phosphorylation site [posttranslational modification] 271065004604 intermolecular recognition site; other site 271065004605 dimerization interface [polypeptide binding]; other site 271065004606 PAS domain S-box; Region: sensory_box; TIGR00229 271065004607 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065004608 putative active site [active] 271065004609 heme pocket [chemical binding]; other site 271065004610 PAS domain S-box; Region: sensory_box; TIGR00229 271065004611 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065004612 putative active site [active] 271065004613 heme pocket [chemical binding]; other site 271065004614 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 271065004615 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065004616 putative active site [active] 271065004617 heme pocket [chemical binding]; other site 271065004618 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065004619 dimer interface [polypeptide binding]; other site 271065004620 phosphorylation site [posttranslational modification] 271065004621 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065004622 ATP binding site [chemical binding]; other site 271065004623 Mg2+ binding site [ion binding]; other site 271065004624 G-X-G motif; other site 271065004625 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065004626 Response regulator receiver domain; Region: Response_reg; pfam00072 271065004627 active site 271065004628 phosphorylation site [posttranslational modification] 271065004629 intermolecular recognition site; other site 271065004630 dimerization interface [polypeptide binding]; other site 271065004631 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 271065004632 Response regulator receiver domain; Region: Response_reg; pfam00072 271065004633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065004634 active site 271065004635 phosphorylation site [posttranslational modification] 271065004636 intermolecular recognition site; other site 271065004637 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 271065004638 dimerization interface [polypeptide binding]; other site 271065004639 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065004640 dimer interface [polypeptide binding]; other site 271065004641 phosphorylation site [posttranslational modification] 271065004642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065004643 ATP binding site [chemical binding]; other site 271065004644 Mg2+ binding site [ion binding]; other site 271065004645 G-X-G motif; other site 271065004646 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 271065004647 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065004648 Walker A/P-loop; other site 271065004649 ATP binding site [chemical binding]; other site 271065004650 Q-loop/lid; other site 271065004651 ABC transporter signature motif; other site 271065004652 Walker B; other site 271065004653 D-loop; other site 271065004654 H-loop/switch region; other site 271065004655 Protein of unknown function (DUF489); Region: DUF489; cl01097 271065004656 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 271065004657 active site residue [active] 271065004658 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 271065004659 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065004660 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 271065004661 metal-binding site [ion binding] 271065004662 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 271065004663 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 271065004664 metal-binding site [ion binding] 271065004665 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 271065004666 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271065004667 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271065004668 PAS fold; Region: PAS; pfam00989 271065004669 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065004670 metal binding site [ion binding]; metal-binding site 271065004671 active site 271065004672 I-site; other site 271065004673 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065004674 GAF domain; Region: GAF; cl15785 271065004675 GAF domain; Region: GAF_2; pfam13185 271065004676 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065004677 metal binding site [ion binding]; metal-binding site 271065004678 active site 271065004679 I-site; other site 271065004680 V-type ATP synthase subunit B; Provisional; Region: PRK02118 271065004681 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 271065004682 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 271065004683 Walker A motif homologous position; other site 271065004684 Walker B motif; other site 271065004685 ATP synthase subunit D; Region: ATP-synt_D; cl00613 271065004686 V-type ATP synthase subunit I; Validated; Region: PRK05771 271065004687 V-type ATP synthase subunit K; Provisional; Region: PRK09621 271065004688 Plant ATP synthase F0; Region: YMF19; cl07975 271065004689 V-type ATP synthase subunit A; Provisional; Region: PRK04192 271065004690 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 271065004691 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 271065004692 Walker A motif/ATP binding site; other site 271065004693 Walker B motif; other site 271065004694 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 271065004695 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 271065004696 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 271065004697 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271065004698 dimer interface [polypeptide binding]; other site 271065004699 putative CheW interface [polypeptide binding]; other site 271065004700 Low molecular weight phosphatase family; Region: LMWPc; cd00115 271065004701 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 271065004702 active site 271065004703 Dienelactone hydrolase family; Region: DLH; pfam01738 271065004704 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271065004705 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 271065004706 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 271065004707 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 271065004708 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 271065004709 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 271065004710 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 271065004711 NlpC/P60 family; Region: NLPC_P60; cl11438 271065004712 Phospholipid methyltransferase; Region: PEMT; cl00763 271065004713 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 271065004714 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271065004715 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271065004716 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271065004717 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 271065004718 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 271065004719 AMP-binding enzyme; Region: AMP-binding; cl15778 271065004720 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 271065004721 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271065004722 dimer interface [polypeptide binding]; other site 271065004723 putative CheW interface [polypeptide binding]; other site 271065004724 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271065004725 Sensors of blue-light using FAD; Region: BLUF; cl04855 271065004726 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 271065004727 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 271065004728 Cysteine-rich domain; Region: CCG; pfam02754 271065004729 Cysteine-rich domain; Region: CCG; pfam02754 271065004730 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 271065004731 FAD binding domain; Region: FAD_binding_4; pfam01565 271065004732 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 271065004733 FAD binding domain; Region: FAD_binding_4; pfam01565 271065004734 Cupin domain; Region: Cupin_2; cl09118 271065004735 Sensors of blue-light using FAD; Region: BLUF; cl04855 271065004736 Phosphate-starvation-inducible E; Region: PsiE; cl01264 271065004737 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271065004738 ligand binding site [chemical binding]; other site 271065004739 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 271065004740 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 271065004741 Domain of unknown function (DUF389); Region: DUF389; cl00781 271065004742 Mechanosensitive ion channel; Region: MS_channel; pfam00924 271065004743 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 271065004744 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 271065004745 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 271065004746 putative active site [active] 271065004747 putative active site [active] 271065004748 catalytic site [active] 271065004749 catalytic site [active] 271065004750 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 271065004751 putative active site [active] 271065004752 catalytic site [active] 271065004753 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 271065004754 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 271065004755 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 271065004756 putative catalytic site [active] 271065004757 putative metal binding site [ion binding]; other site 271065004758 putative phosphate binding site [ion binding]; other site 271065004759 BON domain; Region: BON; cl02771 271065004760 Mechanosensitive ion channel; Region: MS_channel; pfam00924 271065004761 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 271065004762 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347 271065004763 active site 271065004764 catalytic site [active] 271065004765 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 271065004766 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 271065004767 ATP-binding site [chemical binding]; other site 271065004768 Gluconate-6-phosphate binding site [chemical binding]; other site 271065004769 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 271065004770 Strictosidine synthase; Region: Str_synth; pfam03088 271065004771 Protein of unknown function (DUF3680); Region: DUF3680; cl02189 271065004772 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 271065004773 circadian clock protein KaiC; Reviewed; Region: PRK09302 271065004774 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065004775 ATP binding site [chemical binding]; other site 271065004776 Walker A motif; other site 271065004777 Walker B motif; other site 271065004778 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065004779 Walker A motif; other site 271065004780 ATP binding site [chemical binding]; other site 271065004781 Walker B motif; other site 271065004782 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 271065004783 tetramer interface [polypeptide binding]; other site 271065004784 dimer interface [polypeptide binding]; other site 271065004785 PAS domain S-box; Region: sensory_box; TIGR00229 271065004786 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065004787 putative active site [active] 271065004788 heme pocket [chemical binding]; other site 271065004789 GAF domain; Region: GAF_2; pfam13185 271065004790 GAF domain; Region: GAF; cl15785 271065004791 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065004792 metal binding site [ion binding]; metal-binding site 271065004793 active site 271065004794 I-site; other site 271065004795 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065004796 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 271065004797 NAD binding site [chemical binding]; other site 271065004798 homodimer interface [polypeptide binding]; other site 271065004799 active site 271065004800 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 271065004801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065004802 active site 271065004803 phosphorylation site [posttranslational modification] 271065004804 intermolecular recognition site; other site 271065004805 dimerization interface [polypeptide binding]; other site 271065004806 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271065004807 DNA binding site [nucleotide binding] 271065004808 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 271065004809 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 271065004810 dimerization interface [polypeptide binding]; other site 271065004811 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065004812 dimer interface [polypeptide binding]; other site 271065004813 phosphorylation site [posttranslational modification] 271065004814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065004815 ATP binding site [chemical binding]; other site 271065004816 Mg2+ binding site [ion binding]; other site 271065004817 G-X-G motif; other site 271065004818 pyruvate phosphate dikinase; Provisional; Region: PRK09279 271065004819 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 271065004820 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 271065004821 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 271065004822 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 271065004823 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 271065004824 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 271065004825 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 271065004826 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 271065004827 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 271065004828 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 271065004829 active site 271065004830 metal binding site [ion binding]; metal-binding site 271065004831 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 271065004832 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065004833 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 271065004834 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 271065004835 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 271065004836 Tetratricopeptide repeat; Region: TPR_12; pfam13424 271065004837 HDOD domain; Region: HDOD; pfam08668 271065004838 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 271065004839 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271065004840 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 271065004841 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 271065004842 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065004843 S-adenosylmethionine binding site [chemical binding]; other site 271065004844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 271065004845 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 271065004846 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271065004847 FeS/SAM binding site; other site 271065004848 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 271065004849 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 271065004850 GSH binding site [chemical binding]; other site 271065004851 catalytic residues [active] 271065004852 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 271065004853 active site 271065004854 intersubunit interface [polypeptide binding]; other site 271065004855 Zn2+ binding site [ion binding]; other site 271065004856 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 271065004857 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 271065004858 heme binding site [chemical binding]; other site 271065004859 ferroxidase pore; other site 271065004860 ferroxidase diiron center [ion binding]; other site 271065004861 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 271065004862 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 271065004863 Proline dehydrogenase; Region: Pro_dh; cl03282 271065004864 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 271065004865 Glutamate binding site [chemical binding]; other site 271065004866 NAD binding site [chemical binding]; other site 271065004867 catalytic residues [active] 271065004868 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 271065004869 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271065004870 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 271065004871 Erythromycin esterase; Region: Erythro_esteras; pfam05139 271065004872 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 271065004873 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 271065004874 Nucleoside recognition; Region: Gate; cl00486 271065004875 Nucleoside recognition; Region: Gate; cl00486 271065004876 Response regulator receiver domain; Region: Response_reg; pfam00072 271065004877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065004878 active site 271065004879 phosphorylation site [posttranslational modification] 271065004880 intermolecular recognition site; other site 271065004881 dimerization interface [polypeptide binding]; other site 271065004882 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 271065004883 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271065004884 DNA binding residues [nucleotide binding] 271065004885 Sodium:solute symporter family; Region: SSF; cl00456 271065004886 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 271065004887 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065004888 dimer interface [polypeptide binding]; other site 271065004889 phosphorylation site [posttranslational modification] 271065004890 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065004891 ATP binding site [chemical binding]; other site 271065004892 Mg2+ binding site [ion binding]; other site 271065004893 G-X-G motif; other site 271065004894 Response regulator receiver domain; Region: Response_reg; pfam00072 271065004895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065004896 active site 271065004897 phosphorylation site [posttranslational modification] 271065004898 intermolecular recognition site; other site 271065004899 dimerization interface [polypeptide binding]; other site 271065004900 SdiA-regulated; Region: SdiA-regulated; pfam06977 271065004901 SdiA-regulated; Region: SdiA-regulated; cd09971 271065004902 putative active site [active] 271065004903 CheB methylesterase; Region: CheB_methylest; pfam01339 271065004904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065004905 active site 271065004906 phosphorylation site [posttranslational modification] 271065004907 intermolecular recognition site; other site 271065004908 dimerization interface [polypeptide binding]; other site 271065004909 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271065004910 DNA binding residues [nucleotide binding] 271065004911 dimerization interface [polypeptide binding]; other site 271065004912 Sodium:solute symporter family; Region: SSF; cl00456 271065004913 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065004914 dimer interface [polypeptide binding]; other site 271065004915 phosphorylation site [posttranslational modification] 271065004916 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065004917 ATP binding site [chemical binding]; other site 271065004918 Mg2+ binding site [ion binding]; other site 271065004919 G-X-G motif; other site 271065004920 Response regulator receiver domain; Region: Response_reg; pfam00072 271065004921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065004922 active site 271065004923 phosphorylation site [posttranslational modification] 271065004924 intermolecular recognition site; other site 271065004925 dimerization interface [polypeptide binding]; other site 271065004926 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 271065004927 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 271065004928 putative ligand binding site [chemical binding]; other site 271065004929 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 271065004930 TM-ABC transporter signature motif; other site 271065004931 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 271065004932 TM-ABC transporter signature motif; other site 271065004933 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 271065004934 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 271065004935 Walker A/P-loop; other site 271065004936 ATP binding site [chemical binding]; other site 271065004937 Q-loop/lid; other site 271065004938 ABC transporter signature motif; other site 271065004939 Walker B; other site 271065004940 D-loop; other site 271065004941 H-loop/switch region; other site 271065004942 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 271065004943 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 271065004944 Walker A/P-loop; other site 271065004945 ATP binding site [chemical binding]; other site 271065004946 Q-loop/lid; other site 271065004947 ABC transporter signature motif; other site 271065004948 Walker B; other site 271065004949 D-loop; other site 271065004950 H-loop/switch region; other site 271065004951 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 271065004952 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 271065004953 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 271065004954 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271065004955 non-specific DNA binding site [nucleotide binding]; other site 271065004956 salt bridge; other site 271065004957 sequence-specific DNA binding site [nucleotide binding]; other site 271065004958 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 271065004959 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271065004960 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 271065004961 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 271065004962 potential frameshift: common BLAST hit: gi|344200426|ref|YP_004784752.1| transposase IS204/IS1001/IS1096/IS1165 family protein 271065004963 Transposase; Region: DDE_Tnp_ISL3; pfam01610 271065004964 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 271065004965 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 271065004966 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 271065004967 TM-ABC transporter signature motif; other site 271065004968 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 271065004969 TM-ABC transporter signature motif; other site 271065004970 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 271065004971 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 271065004972 Walker A/P-loop; other site 271065004973 ATP binding site [chemical binding]; other site 271065004974 Q-loop/lid; other site 271065004975 ABC transporter signature motif; other site 271065004976 Walker B; other site 271065004977 D-loop; other site 271065004978 H-loop/switch region; other site 271065004979 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 271065004980 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 271065004981 Walker A/P-loop; other site 271065004982 ATP binding site [chemical binding]; other site 271065004983 Q-loop/lid; other site 271065004984 ABC transporter signature motif; other site 271065004985 Walker B; other site 271065004986 D-loop; other site 271065004987 H-loop/switch region; other site 271065004988 HupE / UreJ protein; Region: HupE_UreJ; cl01011 271065004989 UreD urease accessory protein; Region: UreD; cl00530 271065004990 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 271065004991 alpha-gamma subunit interface [polypeptide binding]; other site 271065004992 beta-gamma subunit interface [polypeptide binding]; other site 271065004993 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 271065004994 gamma-beta subunit interface [polypeptide binding]; other site 271065004995 alpha-beta subunit interface [polypeptide binding]; other site 271065004996 urease subunit alpha; Reviewed; Region: ureC; PRK13207 271065004997 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 271065004998 subunit interactions [polypeptide binding]; other site 271065004999 active site 271065005000 flap region; other site 271065005001 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 271065005002 dimer interface [polypeptide binding]; other site 271065005003 catalytic residues [active] 271065005004 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 271065005005 UreF; Region: UreF; pfam01730 271065005006 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065005007 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 271065005008 dihydrodipicolinate synthase; Region: dapA; TIGR00674 271065005009 dimer interface [polypeptide binding]; other site 271065005010 active site 271065005011 catalytic residue [active] 271065005012 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 271065005013 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 271065005014 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 271065005015 dimerization interface [polypeptide binding]; other site 271065005016 ATP binding site [chemical binding]; other site 271065005017 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 271065005018 dimerization interface [polypeptide binding]; other site 271065005019 ATP binding site [chemical binding]; other site 271065005020 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 271065005021 putative active site [active] 271065005022 catalytic triad [active] 271065005023 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 271065005024 putative dimer interface [polypeptide binding]; other site 271065005025 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 271065005026 integron integrase; Region: integrase_gron; TIGR02249 271065005027 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 271065005028 Int/Topo IB signature motif; other site 271065005029 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 271065005030 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 271065005031 Catalytic domain of Protein Kinases; Region: PKc; cd00180 271065005032 active site 271065005033 ATP binding site [chemical binding]; other site 271065005034 substrate binding site [chemical binding]; other site 271065005035 activation loop (A-loop); other site 271065005036 Protein of unknown function (DUF3680); Region: DUF3680; cl02189 271065005037 Haem-binding domain; Region: Haem_bd; pfam14376 271065005038 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 271065005039 Transposase IS200 like; Region: Y1_Tnp; cl00848 271065005040 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 271065005041 putative active site pocket [active] 271065005042 dimerization interface [polypeptide binding]; other site 271065005043 putative catalytic residue [active] 271065005044 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 271065005045 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271065005046 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 271065005047 putative active site [active] 271065005048 Ap4A binding site [chemical binding]; other site 271065005049 nudix motif; other site 271065005050 putative metal binding site [ion binding]; other site 271065005051 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 271065005052 hexamer interface [polypeptide binding]; other site 271065005053 active site 271065005054 metal binding site [ion binding]; metal-binding site 271065005055 N-acetylglutamate synthase; Validated; Region: PRK05279 271065005056 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 271065005057 putative feedback inhibition sensing region; other site 271065005058 putative nucleotide binding site [chemical binding]; other site 271065005059 putative substrate binding site [chemical binding]; other site 271065005060 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271065005061 Coenzyme A binding pocket [chemical binding]; other site 271065005062 Dehydratase family; Region: ILVD_EDD; cl00340 271065005063 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 271065005064 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 271065005065 ornithine carbamoyltransferase; Provisional; Region: PRK00779 271065005066 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 271065005067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065005068 acetylornithine aminotransferase; Provisional; Region: PRK02627 271065005069 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 271065005070 inhibitor-cofactor binding pocket; inhibition site 271065005071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271065005072 catalytic residue [active] 271065005073 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 271065005074 putative GSH binding site [chemical binding]; other site 271065005075 catalytic residues [active] 271065005076 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 271065005077 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 271065005078 dimer interface [polypeptide binding]; other site 271065005079 catalytic site [active] 271065005080 putative active site [active] 271065005081 putative substrate binding site [chemical binding]; other site 271065005082 VacJ like lipoprotein; Region: VacJ; cl01073 271065005083 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 271065005084 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 271065005085 Transglycosylase; Region: Transgly; cl07896 271065005086 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 271065005087 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 271065005088 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 271065005089 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 271065005090 catalytic site [active] 271065005091 subunit interface [polypeptide binding]; other site 271065005092 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 271065005093 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 271065005094 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271065005095 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 271065005096 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 271065005097 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271065005098 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 271065005099 IMP binding site; other site 271065005100 dimer interface [polypeptide binding]; other site 271065005101 interdomain contacts; other site 271065005102 partial ornithine binding site; other site 271065005103 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 271065005104 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 271065005105 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 271065005106 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 271065005107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 271065005108 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 271065005109 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 271065005110 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065005111 Walker A motif; other site 271065005112 ATP binding site [chemical binding]; other site 271065005113 Walker B motif; other site 271065005114 arginine finger; other site 271065005115 Peptidase family M41; Region: Peptidase_M41; pfam01434 271065005116 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 271065005117 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 271065005118 active site 271065005119 substrate binding site [chemical binding]; other site 271065005120 metal binding site [ion binding]; metal-binding site 271065005121 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 271065005122 substrate binding site [chemical binding]; other site 271065005123 dimer interface [polypeptide binding]; other site 271065005124 catalytic triad [active] 271065005125 Preprotein translocase SecG subunit; Region: SecG; cl09123 271065005126 Protein of unknown function (DUF2582); Region: DUF2582; pfam10771 271065005127 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 271065005128 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 271065005129 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271065005130 Helix-turn-helix domains; Region: HTH; cl00088 271065005131 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 271065005132 dimerization interface [polypeptide binding]; other site 271065005133 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 271065005134 active site 271065005135 catalytic residues [active] 271065005136 metal binding site [ion binding]; metal-binding site 271065005137 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 271065005138 Transglycosylase; Region: Transgly; cl07896 271065005139 Cytochrome c; Region: Cytochrom_C; cl11414 271065005140 Cytochrome c; Region: Cytochrom_C; cl11414 271065005141 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 271065005142 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 271065005143 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 271065005144 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065005145 S-adenosylmethionine binding site [chemical binding]; other site 271065005146 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 271065005147 Fumarase C-terminus; Region: Fumerase_C; cl00795 271065005148 Response regulator receiver domain; Region: Response_reg; pfam00072 271065005149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065005150 active site 271065005151 phosphorylation site [posttranslational modification] 271065005152 intermolecular recognition site; other site 271065005153 dimerization interface [polypeptide binding]; other site 271065005154 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 271065005155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065005156 active site 271065005157 phosphorylation site [posttranslational modification] 271065005158 intermolecular recognition site; other site 271065005159 dimerization interface [polypeptide binding]; other site 271065005160 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271065005161 PAS fold; Region: PAS_3; pfam08447 271065005162 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 271065005163 Herpesvirus UL51 protein; Region: Herpes_UL51; pfam04540 271065005164 PAS domain; Region: PAS_9; pfam13426 271065005165 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065005166 PAS domain; Region: PAS_9; pfam13426 271065005167 putative active site [active] 271065005168 heme pocket [chemical binding]; other site 271065005169 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065005170 metal binding site [ion binding]; metal-binding site 271065005171 active site 271065005172 I-site; other site 271065005173 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 271065005174 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 271065005175 aromatic arch; other site 271065005176 DCoH dimer interaction site [polypeptide binding]; other site 271065005177 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 271065005178 DCoH tetramer interaction site [polypeptide binding]; other site 271065005179 substrate binding site [chemical binding]; other site 271065005180 phosphoenolpyruvate synthase; Validated; Region: PRK06464 271065005181 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 271065005182 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 271065005183 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 271065005184 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 271065005185 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 271065005186 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 271065005187 PPIC-type PPIASE domain; Region: Rotamase; cl08278 271065005188 BolA-like protein; Region: BolA; cl00386 271065005189 YCII-related domain; Region: YCII; cl00999 271065005190 Intracellular septation protein A; Region: IspA; cl01098 271065005191 Protein of unknown function (DUF1244); Region: DUF1244; cl01385 271065005192 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065005193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065005194 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 271065005195 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 271065005196 putative catalytic cysteine [active] 271065005197 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 271065005198 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 271065005199 active site 271065005200 (T/H)XGH motif; other site 271065005201 Oligomerisation domain; Region: Oligomerisation; cl00519 271065005202 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 271065005203 putative deacylase active site [active] 271065005204 peptide chain release factor 1; Provisional; Region: PRK04011 271065005205 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 271065005206 putative active site [active] 271065005207 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 271065005208 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271065005209 dimerization interface [polypeptide binding]; other site 271065005210 putative DNA binding site [nucleotide binding]; other site 271065005211 putative Zn2+ binding site [ion binding]; other site 271065005212 Low molecular weight phosphatase family; Region: LMWPc; cd00115 271065005213 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 271065005214 active site 271065005215 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 271065005216 Membrane transport protein; Region: Mem_trans; cl09117 271065005217 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 271065005218 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 271065005219 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 271065005220 P loop; other site 271065005221 Nucleotide binding site [chemical binding]; other site 271065005222 DTAP/Switch II; other site 271065005223 Switch I; other site 271065005224 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 271065005225 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 271065005226 P loop; other site 271065005227 Nucleotide binding site [chemical binding]; other site 271065005228 DTAP/Switch II; other site 271065005229 Switch I; other site 271065005230 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 271065005231 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 271065005232 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 271065005233 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 271065005234 protein binding site [polypeptide binding]; other site 271065005235 pyruvate kinase; Validated; Region: PRK08187 271065005236 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 271065005237 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 271065005238 domain interfaces; other site 271065005239 active site 271065005240 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271065005241 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 271065005242 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 271065005243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271065005244 dimer interface [polypeptide binding]; other site 271065005245 conserved gate region; other site 271065005246 putative PBP binding loops; other site 271065005247 ABC-ATPase subunit interface; other site 271065005248 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 271065005249 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 271065005250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271065005251 dimer interface [polypeptide binding]; other site 271065005252 conserved gate region; other site 271065005253 putative PBP binding loops; other site 271065005254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 271065005255 ABC-ATPase subunit interface; other site 271065005256 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 271065005257 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 271065005258 Walker A/P-loop; other site 271065005259 ATP binding site [chemical binding]; other site 271065005260 Q-loop/lid; other site 271065005261 ABC transporter signature motif; other site 271065005262 Walker B; other site 271065005263 D-loop; other site 271065005264 H-loop/switch region; other site 271065005265 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 271065005266 PhoU domain; Region: PhoU; pfam01895 271065005267 PhoU domain; Region: PhoU; pfam01895 271065005268 Predicted GTPase [General function prediction only]; Region: COG2403 271065005269 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 271065005270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271065005271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 271065005272 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 271065005273 Helix-turn-helix domains; Region: HTH; cl00088 271065005274 Protein of unknown function (DUF3422); Region: DUF3422; cl02073 271065005275 N-carbamolyputrescine amidase; Region: PLN02747 271065005276 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 271065005277 putative active site; other site 271065005278 catalytic triad [active] 271065005279 putative dimer interface [polypeptide binding]; other site 271065005280 agmatine deiminase; Region: agmatine_aguA; TIGR03380 271065005281 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 271065005282 recombination and repair protein; Provisional; Region: PRK10869 271065005283 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 271065005284 Walker A/P-loop; other site 271065005285 ATP binding site [chemical binding]; other site 271065005286 Q-loop/lid; other site 271065005287 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 271065005288 ABC transporter signature motif; other site 271065005289 Walker B; other site 271065005290 D-loop; other site 271065005291 H-loop/switch region; other site 271065005292 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 271065005293 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 271065005294 Helix-turn-helix domains; Region: HTH; cl00088 271065005295 HrcA protein C terminal domain; Region: HrcA; pfam01628 271065005296 heat shock protein GrpE; Provisional; Region: PRK14140 271065005297 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 271065005298 dimer interface [polypeptide binding]; other site 271065005299 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 271065005300 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 271065005301 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 271065005302 chaperone protein DnaJ; Provisional; Region: PRK10767 271065005303 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 271065005304 HSP70 interaction site [polypeptide binding]; other site 271065005305 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 271065005306 substrate binding site [polypeptide binding]; other site 271065005307 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 271065005308 Zn binding sites [ion binding]; other site 271065005309 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 271065005310 dimer interface [polypeptide binding]; other site 271065005311 dihydrodipicolinate reductase; Provisional; Region: PRK00048 271065005312 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065005313 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 271065005314 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 271065005315 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 271065005316 catalytic loop [active] 271065005317 iron binding site [ion binding]; other site 271065005318 4Fe-4S binding domain; Region: Fer4; cl02805 271065005319 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 271065005320 [4Fe-4S] binding site [ion binding]; other site 271065005321 molybdopterin cofactor binding site; other site 271065005322 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 271065005323 molybdopterin cofactor binding site; other site 271065005324 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 271065005325 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082 271065005326 putative dimer interface [polypeptide binding]; other site 271065005327 [2Fe-2S] cluster binding site [ion binding]; other site 271065005328 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 271065005329 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 271065005330 SLBB domain; Region: SLBB; pfam10531 271065005331 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 271065005332 Helix-turn-helix domains; Region: HTH; cl00088 271065005333 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 271065005334 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 271065005335 putative dimerization interface [polypeptide binding]; other site 271065005336 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 271065005337 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 271065005338 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 271065005339 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 271065005340 putative active site [active] 271065005341 Domain of unknown function DUF302; Region: DUF302; cl01364 271065005342 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 271065005343 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 271065005344 GTP binding site; other site 271065005345 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 271065005346 Protein of unknown function (DUF2835); Region: DUF2835; pfam11197 271065005347 Peptidase family M48; Region: Peptidase_M48; cl12018 271065005348 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 271065005349 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 271065005350 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 271065005351 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 271065005352 dimer interface [polypeptide binding]; other site 271065005353 ADP-ribose binding site [chemical binding]; other site 271065005354 active site 271065005355 nudix motif; other site 271065005356 metal binding site [ion binding]; metal-binding site 271065005357 Predicted membrane protein [Function unknown]; Region: COG3671 271065005358 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 271065005359 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 271065005360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065005361 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 271065005362 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 271065005363 putative NAD(P) binding site [chemical binding]; other site 271065005364 active site 271065005365 putative substrate binding site [chemical binding]; other site 271065005366 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 271065005367 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 271065005368 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 271065005369 putative ADP-binding pocket [chemical binding]; other site 271065005370 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 271065005371 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 271065005372 active site 271065005373 dimer interface [polypeptide binding]; other site 271065005374 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 271065005375 Ligand Binding Site [chemical binding]; other site 271065005376 Molecular Tunnel; other site 271065005377 PilZ domain; Region: PilZ; cl01260 271065005378 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 271065005379 MASE1; Region: MASE1; pfam05231 271065005380 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065005381 dimer interface [polypeptide binding]; other site 271065005382 phosphorylation site [posttranslational modification] 271065005383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065005384 ATP binding site [chemical binding]; other site 271065005385 Mg2+ binding site [ion binding]; other site 271065005386 G-X-G motif; other site 271065005387 Response regulator receiver domain; Region: Response_reg; pfam00072 271065005388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065005389 active site 271065005390 phosphorylation site [posttranslational modification] 271065005391 intermolecular recognition site; other site 271065005392 dimerization interface [polypeptide binding]; other site 271065005393 Cytochrome c; Region: Cytochrom_C; cl11414 271065005394 MASE1; Region: MASE1; pfam05231 271065005395 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065005396 PAS domain; Region: PAS_9; pfam13426 271065005397 putative active site [active] 271065005398 heme pocket [chemical binding]; other site 271065005399 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065005400 metal binding site [ion binding]; metal-binding site 271065005401 active site 271065005402 I-site; other site 271065005403 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065005404 prolyl-tRNA synthetase; Provisional; Region: PRK09194 271065005405 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 271065005406 dimer interface [polypeptide binding]; other site 271065005407 motif 1; other site 271065005408 active site 271065005409 motif 2; other site 271065005410 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 271065005411 putative deacylase active site [active] 271065005412 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 271065005413 active site 271065005414 motif 3; other site 271065005415 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 271065005416 anticodon binding site; other site 271065005417 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 271065005418 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 271065005419 active site 271065005420 dimer interface [polypeptide binding]; other site 271065005421 magnesium binding site [ion binding]; other site 271065005422 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 271065005423 tetramer interface [polypeptide binding]; other site 271065005424 active site 271065005425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271065005426 Major Facilitator Superfamily; Region: MFS_1; pfam07690 271065005427 putative substrate translocation pore; other site 271065005428 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 271065005429 dimer interface [polypeptide binding]; other site 271065005430 ssDNA binding site [nucleotide binding]; other site 271065005431 tetramer (dimer of dimers) interface [polypeptide binding]; other site 271065005432 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 271065005433 flagellar motor protein MotB; Reviewed; Region: motB; PRK08944 271065005434 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 271065005435 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271065005436 ligand binding site [chemical binding]; other site 271065005437 PilZ domain; Region: PilZ; cl01260 271065005438 Helix-turn-helix domains; Region: HTH; cl00088 271065005439 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 271065005440 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 271065005441 Type III pantothenate kinase; Region: Pan_kinase; cl09130 271065005442 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 271065005443 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 271065005444 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 271065005445 Sporulation related domain; Region: SPOR; cl10051 271065005446 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 271065005447 Protein of unknown function (DUF541); Region: SIMPL; cl01077 271065005448 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 271065005449 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 271065005450 phosphopeptide binding site; other site 271065005451 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 271065005452 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 271065005453 hypothetical protein; Provisional; Region: PRK07033 271065005454 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 271065005455 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271065005456 ligand binding site [chemical binding]; other site 271065005457 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 271065005458 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 271065005459 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 271065005460 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 271065005461 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 271065005462 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 271065005463 active site 271065005464 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 271065005465 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 271065005466 Protein of unknown function (DUF770); Region: DUF770; cl01402 271065005467 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 271065005468 Protein of unknown function (DUF877); Region: DUF877; pfam05943 271065005469 Protein of unknown function (DUF796); Region: DUF796; cl01226 271065005470 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 271065005471 ImpE protein; Region: ImpE; pfam07024 271065005472 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 271065005473 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 271065005474 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 271065005475 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 271065005476 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 271065005477 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065005478 Walker A motif; other site 271065005479 ATP binding site [chemical binding]; other site 271065005480 Walker B motif; other site 271065005481 arginine finger; other site 271065005482 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065005483 Walker A motif; other site 271065005484 ATP binding site [chemical binding]; other site 271065005485 Walker B motif; other site 271065005486 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 271065005487 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 271065005488 putative active site [active] 271065005489 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 271065005490 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 271065005491 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 271065005492 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 271065005493 PAAR motif; Region: PAAR_motif; cl15808 271065005494 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 271065005495 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 271065005496 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 271065005497 baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596 271065005498 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 271065005499 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 271065005500 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 271065005501 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 271065005502 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 271065005503 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 271065005504 active site 271065005505 PAAR motif; Region: PAAR_motif; cl15808 271065005506 Helix-turn-helix domains; Region: HTH; cl00088 271065005507 rod shape-determining protein MreC; Provisional; Region: PRK13922 271065005508 putative transposase OrfB; Reviewed; Region: PHA02517 271065005509 Helix-turn-helix domains; Region: HTH; cl00088 271065005510 Integrase core domain; Region: rve; cl01316 271065005511 Integrase core domain; Region: rve_3; cl15866 271065005512 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 271065005513 putative active site [active] 271065005514 conserved hypothetical protein; Region: TIGR02270 271065005515 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 271065005516 Catalytic domain of Protein Kinases; Region: PKc; cd00180 271065005517 active site 271065005518 ATP binding site [chemical binding]; other site 271065005519 substrate binding site [chemical binding]; other site 271065005520 activation loop (A-loop); other site 271065005521 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 271065005522 Catalytic domain of Protein Kinases; Region: PKc; cd00180 271065005523 active site 271065005524 ATP binding site [chemical binding]; other site 271065005525 substrate binding site [chemical binding]; other site 271065005526 activation loop (A-loop); other site 271065005527 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 271065005528 binding surface 271065005529 TPR motif; other site 271065005530 PAS domain; Region: PAS_9; pfam13426 271065005531 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065005532 PAS domain; Region: PAS_9; pfam13426 271065005533 putative active site [active] 271065005534 heme pocket [chemical binding]; other site 271065005535 PAS domain S-box; Region: sensory_box; TIGR00229 271065005536 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065005537 putative active site [active] 271065005538 heme pocket [chemical binding]; other site 271065005539 PAS domain S-box; Region: sensory_box; TIGR00229 271065005540 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065005541 putative active site [active] 271065005542 heme pocket [chemical binding]; other site 271065005543 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 271065005544 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 271065005545 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 271065005546 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271065005547 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271065005548 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 271065005549 Rubredoxin; Region: Rubredoxin; pfam00301 271065005550 iron binding site [ion binding]; other site 271065005551 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 271065005552 hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418 271065005553 HupF/HypC family; Region: HupF_HypC; cl00394 271065005554 HupE / UreJ protein; Region: HupE_UreJ; cl01011 271065005555 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 271065005556 dimerization interface [polypeptide binding]; other site 271065005557 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 271065005558 ATP binding site [chemical binding]; other site 271065005559 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 271065005560 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065005561 active site 271065005562 phosphorylation site [posttranslational modification] 271065005563 intermolecular recognition site; other site 271065005564 dimerization interface [polypeptide binding]; other site 271065005565 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271065005566 DNA binding site [nucleotide binding] 271065005567 Sulfate transporter family; Region: Sulfate_transp; cl15842 271065005568 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 271065005569 Ligand Binding Site [chemical binding]; other site 271065005570 Acylphosphatase; Region: Acylphosphatase; cl00551 271065005571 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 271065005572 HypF finger; Region: zf-HYPF; pfam07503 271065005573 HypF finger; Region: zf-HYPF; pfam07503 271065005574 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 271065005575 Hydrogenase formation hypA family; Region: HypD; cl12072 271065005576 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409 271065005577 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065005578 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 271065005579 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 271065005580 dimer interface [polypeptide binding]; other site 271065005581 active site 271065005582 metal binding site [ion binding]; metal-binding site 271065005583 glutathione binding site [chemical binding]; other site 271065005584 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 271065005585 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 271065005586 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 271065005587 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271065005588 catalytic residue [active] 271065005589 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 271065005590 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 271065005591 active site 271065005592 metal binding site [ion binding]; metal-binding site 271065005593 Protein of unknown function (DUF1255); Region: DUF1255; cl01202 271065005594 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 271065005595 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271065005596 ATP binding site [chemical binding]; other site 271065005597 putative Mg++ binding site [ion binding]; other site 271065005598 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271065005599 nucleotide binding region [chemical binding]; other site 271065005600 ATP-binding site [chemical binding]; other site 271065005601 Helicase associated domain (HA2); Region: HA2; cl04503 271065005602 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 271065005603 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 271065005604 putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073 271065005605 hypothetical protein; Provisional; Region: PRK08317 271065005606 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065005607 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 271065005608 HopJ type III effector protein; Region: HopJ; pfam08888 271065005609 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 271065005610 SmpB-tmRNA interface; other site 271065005611 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 271065005612 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 271065005613 putative coenzyme Q binding site [chemical binding]; other site 271065005614 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 271065005615 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 271065005616 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 271065005617 metal binding site 2 [ion binding]; metal-binding site 271065005618 putative DNA binding helix; other site 271065005619 metal binding site 1 [ion binding]; metal-binding site 271065005620 dimer interface [polypeptide binding]; other site 271065005621 structural Zn2+ binding site [ion binding]; other site 271065005622 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 271065005623 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 271065005624 FtsX-like permease family; Region: FtsX; cl15850 271065005625 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 271065005626 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 271065005627 Walker A/P-loop; other site 271065005628 ATP binding site [chemical binding]; other site 271065005629 Q-loop/lid; other site 271065005630 ABC transporter signature motif; other site 271065005631 Walker B; other site 271065005632 D-loop; other site 271065005633 H-loop/switch region; other site 271065005634 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 271065005635 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 271065005636 ComEC family competence protein; Provisional; Region: PRK11539 271065005637 Competence protein; Region: Competence; cl00471 271065005638 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 271065005639 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 271065005640 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271065005641 putative Zn2+ binding site [ion binding]; other site 271065005642 putative DNA binding site [nucleotide binding]; other site 271065005643 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 271065005644 putative ABC transporter; Region: ycf24; CHL00085 271065005645 YcfA-like protein; Region: YcfA; cl00752 271065005646 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 271065005647 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 271065005648 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 271065005649 Walker A/P-loop; other site 271065005650 ATP binding site [chemical binding]; other site 271065005651 Q-loop/lid; other site 271065005652 ABC transporter signature motif; other site 271065005653 Walker B; other site 271065005654 D-loop; other site 271065005655 H-loop/switch region; other site 271065005656 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 271065005657 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 271065005658 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 271065005659 putative active site [active] 271065005660 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 271065005661 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 271065005662 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271065005663 catalytic residue [active] 271065005664 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 271065005665 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 271065005666 trimerization site [polypeptide binding]; other site 271065005667 active site 271065005668 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065005669 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 271065005670 [2Fe-2S] cluster binding site [ion binding]; other site 271065005671 peptide chain release factor 2; Validated; Region: prfB; PRK00578 271065005672 RF-1 domain; Region: RF-1; cl02875 271065005673 RF-1 domain; Region: RF-1; cl02875 271065005674 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 271065005675 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 271065005676 dimer interface [polypeptide binding]; other site 271065005677 putative anticodon binding site; other site 271065005678 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 271065005679 motif 1; other site 271065005680 active site 271065005681 motif 2; other site 271065005682 motif 3; other site 271065005683 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 271065005684 putative active site [active] 271065005685 VanZ like family; Region: VanZ; cl01971 271065005686 Phosphate-selective porin O and P; Region: Porin_O_P; cl01524 271065005687 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271065005688 PAS domain S-box; Region: sensory_box; TIGR00229 271065005689 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065005690 metal binding site [ion binding]; metal-binding site 271065005691 active site 271065005692 I-site; other site 271065005693 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065005694 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271065005695 hypothetical protein; Provisional; Region: PRK08317 271065005696 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065005697 S-adenosylmethionine binding site [chemical binding]; other site 271065005698 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 271065005699 active site 271065005700 PilZ domain; Region: PilZ; cl01260 271065005701 DNA polymerase III subunit delta'; Validated; Region: PRK05707 271065005702 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065005703 thymidylate kinase; Validated; Region: tmk; PRK00698 271065005704 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 271065005705 TMP-binding site; other site 271065005706 ATP-binding site [chemical binding]; other site 271065005707 YceG-like family; Region: YceG; pfam02618 271065005708 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 271065005709 dimerization interface [polypeptide binding]; other site 271065005710 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 271065005711 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271065005712 catalytic residue [active] 271065005713 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 271065005714 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 271065005715 dimer interface [polypeptide binding]; other site 271065005716 active site 271065005717 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271065005718 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 271065005719 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 271065005720 NAD(P) binding site [chemical binding]; other site 271065005721 homotetramer interface [polypeptide binding]; other site 271065005722 homodimer interface [polypeptide binding]; other site 271065005723 active site 271065005724 Acyl transferase domain; Region: Acyl_transf_1; cl08282 271065005725 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 271065005726 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 271065005727 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 271065005728 dimer interface [polypeptide binding]; other site 271065005729 active site 271065005730 CoA binding pocket [chemical binding]; other site 271065005731 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 271065005732 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 271065005733 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 271065005734 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 271065005735 active site 271065005736 dimer interface [polypeptide binding]; other site 271065005737 HDOD domain; Region: HDOD; pfam08668 271065005738 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 271065005739 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 271065005740 N-acetyl-D-glucosamine binding site [chemical binding]; other site 271065005741 catalytic residue [active] 271065005742 The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also possess a conserved ATPase activity that...; Region: ABC_MutS_homologs; cd03243 271065005743 Walker A/P-loop; other site 271065005744 ATP binding site [chemical binding]; other site 271065005745 Q-loop/lid; other site 271065005746 ABC transporter signature motif; other site 271065005747 Walker B; other site 271065005748 D-loop; other site 271065005749 H-loop/switch region; other site 271065005750 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 271065005751 GTP cyclohydrolase I; Provisional; Region: PLN03044 271065005752 homodecamer interface [polypeptide binding]; other site 271065005753 active site 271065005754 putative catalytic site residues [active] 271065005755 zinc binding site [ion binding]; other site 271065005756 GTP-CH-I/GFRP interaction surface; other site 271065005757 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 271065005758 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 271065005759 FMN binding site [chemical binding]; other site 271065005760 active site 271065005761 catalytic residues [active] 271065005762 substrate binding site [chemical binding]; other site 271065005763 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 271065005764 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 271065005765 trimer interface [polypeptide binding]; other site 271065005766 putative metal binding site [ion binding]; other site 271065005767 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 271065005768 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 271065005769 Short C-terminal domain; Region: SHOCT; cl01373 271065005770 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 271065005771 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 271065005772 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 271065005773 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065005774 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 271065005775 ligand binding site [chemical binding]; other site 271065005776 HDOD domain; Region: HDOD; pfam08668 271065005777 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 271065005778 ligand binding site [chemical binding]; other site 271065005779 HDOD domain; Region: HDOD; pfam08668 271065005780 HDOD domain; Region: HDOD; pfam08668 271065005781 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 271065005782 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 271065005783 active site 271065005784 Zn binding site [ion binding]; other site 271065005785 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 271065005786 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 271065005787 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 271065005788 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 271065005789 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 271065005790 putative CheA interaction surface; other site 271065005791 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 271065005792 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271065005793 dimer interface [polypeptide binding]; other site 271065005794 putative CheW interface [polypeptide binding]; other site 271065005795 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 271065005796 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 271065005797 Histidine kinase; Region: HisKA_3; pfam07730 271065005798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 271065005799 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 271065005800 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065005801 active site 271065005802 phosphorylation site [posttranslational modification] 271065005803 intermolecular recognition site; other site 271065005804 dimerization interface [polypeptide binding]; other site 271065005805 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271065005806 DNA binding residues [nucleotide binding] 271065005807 dimerization interface [polypeptide binding]; other site 271065005808 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 271065005809 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065005810 Walker A motif; other site 271065005811 ATP binding site [chemical binding]; other site 271065005812 Walker B motif; other site 271065005813 arginine finger; other site 271065005814 Peptidase family M41; Region: Peptidase_M41; pfam01434 271065005815 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme 271065005816 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme 271065005817 Protein of unknown function DUF45; Region: DUF45; cl00636 271065005818 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 271065005819 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 271065005820 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271065005821 ATP binding site [chemical binding]; other site 271065005822 putative Mg++ binding site [ion binding]; other site 271065005823 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 271065005824 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 271065005825 Fic family protein [Function unknown]; Region: COG3177 271065005826 Fic/DOC family; Region: Fic; cl00960 271065005827 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 271065005828 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 271065005829 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 271065005830 putative active site [active] 271065005831 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 271065005832 HsdM N-terminal domain; Region: HsdM_N; pfam12161 271065005833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065005834 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 271065005835 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 271065005836 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 271065005837 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 271065005838 oligomeric interface; other site 271065005839 putative active site [active] 271065005840 homodimer interface [polypeptide binding]; other site 271065005841 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 271065005842 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 271065005843 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 271065005844 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 271065005845 Protein of unknown function (DUF3262); Region: DUF3262; cl13160 271065005846 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 271065005847 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 271065005848 Domain of unknown function (DUF4400); Region: DUF4400; cl14023 271065005849 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 271065005850 Domain of unknown function DUF87; Region: DUF87; pfam01935 271065005851 HrcA protein C terminal domain; Region: HrcA; pfam01628 271065005852 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 271065005853 Protein of unknown function (DUF2859); Region: DUF2859; cl12633 271065005854 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 271065005855 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 271065005856 LabA_like proteins; Region: LabA_like; cd06167 271065005857 putative metal binding site [ion binding]; other site 271065005858 RES domain; Region: RES; cl02411 271065005859 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 271065005860 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 271065005861 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 271065005862 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 271065005863 metal ion-dependent adhesion site (MIDAS); other site 271065005864 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 271065005865 phosphopeptide binding site; other site 271065005866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 271065005867 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 271065005868 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 271065005869 phosphopeptide binding site; other site 271065005870 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 271065005871 active site 271065005872 Protein kinase domain; Region: Pkinase; pfam00069 271065005873 Catalytic domain of Protein Kinases; Region: PKc; cd00180 271065005874 active site 271065005875 ATP binding site [chemical binding]; other site 271065005876 substrate binding site [chemical binding]; other site 271065005877 activation loop (A-loop); other site 271065005878 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 271065005879 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 271065005880 Protein kinase domain; Region: Pkinase; pfam00069 271065005881 Catalytic domain of Protein Kinases; Region: PKc; cd00180 271065005882 active site 271065005883 ATP binding site [chemical binding]; other site 271065005884 substrate binding site [chemical binding]; other site 271065005885 activation loop (A-loop); other site 271065005886 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 271065005887 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 271065005888 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 271065005889 Protein kinase domain; Region: Pkinase; pfam00069 271065005890 Catalytic domain of Protein Kinases; Region: PKc; cd00180 271065005891 active site 271065005892 ATP binding site [chemical binding]; other site 271065005893 substrate binding site [chemical binding]; other site 271065005894 activation loop (A-loop); other site 271065005895 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 271065005896 phosphopeptide binding site; other site 271065005897 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 271065005898 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 271065005899 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 271065005900 Protein of unknown function (DUF3262); Region: DUF3262; cl13160 271065005901 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 271065005902 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 271065005903 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 271065005904 Helix-turn-helix domains; Region: HTH; cl00088 271065005905 rod shape-determining protein MreC; Provisional; Region: PRK13922 271065005906 Winged helix-turn helix; Region: HTH_29; pfam13551 271065005907 Helix-turn-helix domains; Region: HTH; cl00088 271065005908 Integrase core domain; Region: rve; cl01316 271065005909 Integrase core domain; Region: rve_3; cl15866 271065005910 Protein of unknown function (DUF429); Region: DUF429; cl12046 271065005911 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 271065005912 Presynaptic Site I dimer interface [polypeptide binding]; other site 271065005913 catalytic residues [active] 271065005914 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 271065005915 Synaptic Flat tetramer interface [polypeptide binding]; other site 271065005916 Synaptic Site I dimer interface [polypeptide binding]; other site 271065005917 DNA binding site [nucleotide binding] 271065005918 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 271065005919 DNA-binding interface [nucleotide binding]; DNA binding site 271065005920 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 271065005921 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 271065005922 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271065005923 active site 271065005924 DNA binding site [nucleotide binding] 271065005925 Int/Topo IB signature motif; other site 271065005926 GTP-binding protein YchF; Reviewed; Region: PRK09601 271065005927 YchF GTPase; Region: YchF; cd01900 271065005928 G1 box; other site 271065005929 GTP/Mg2+ binding site [chemical binding]; other site 271065005930 Switch I region; other site 271065005931 G2 box; other site 271065005932 Switch II region; other site 271065005933 G3 box; other site 271065005934 G4 box; other site 271065005935 G5 box; other site 271065005936 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 271065005937 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 271065005938 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 271065005939 HDOD domain; Region: HDOD; pfam08668 271065005940 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 271065005941 Zn2+ binding site [ion binding]; other site 271065005942 Mg2+ binding site [ion binding]; other site 271065005943 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 271065005944 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 271065005945 nucleoside/Zn binding site; other site 271065005946 dimer interface [polypeptide binding]; other site 271065005947 catalytic motif [active] 271065005948 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271065005949 Helix-turn-helix domains; Region: HTH; cl00088 271065005950 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 271065005951 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271065005952 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271065005953 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 271065005954 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 271065005955 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 271065005956 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 271065005957 Fic/DOC family; Region: Fic; cl00960 271065005958 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 271065005959 putative active site [active] 271065005960 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 271065005961 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 271065005962 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 271065005963 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 271065005964 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 271065005965 CRISPR-associated protein Cas8c/Csd1, subtype I-C/DVULG; Region: cas_Csd1; TIGR01863 271065005966 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 271065005967 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09651 271065005968 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 271065005969 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 271065005970 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065005971 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 271065005972 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 271065005973 putative active site [active] 271065005974 putative NTP binding site [chemical binding]; other site 271065005975 putative nucleic acid binding site [nucleotide binding]; other site 271065005976 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 271065005977 Protein of unknown function (DUF1489); Region: DUF1489; cl11570 271065005978 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 271065005979 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065005980 MAEBL; Provisional; Region: PTZ00121 271065005981 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 271065005982 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 271065005983 Baseplate J-like protein; Region: Baseplate_J; cl01294 271065005984 Baseplate J-like protein; Region: Baseplate_J; cl01294 271065005985 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 271065005986 PAAR motif; Region: PAAR_motif; cl15808 271065005987 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 271065005988 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 271065005989 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 271065005990 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 271065005991 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 271065005992 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 271065005993 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 271065005994 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 271065005995 SpoVR family protein; Provisional; Region: PRK11767 271065005996 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 271065005997 Uncharacterized conserved protein [Function unknown]; Region: COG2718 271065005998 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 271065005999 PrkA family serine protein kinase; Provisional; Region: PRK15455 271065006000 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065006001 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 271065006002 Pirin-related protein [General function prediction only]; Region: COG1741 271065006003 Cupin domain; Region: Cupin_2; cl09118 271065006004 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 271065006005 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 271065006006 putative effector binding pocket; other site 271065006007 putative dimerization interface [polypeptide binding]; other site 271065006008 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 271065006009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065006010 intermolecular recognition site; other site 271065006011 active site 271065006012 dimerization interface [polypeptide binding]; other site 271065006013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065006014 Walker A motif; other site 271065006015 ATP binding site [chemical binding]; other site 271065006016 Walker B motif; other site 271065006017 arginine finger; other site 271065006018 Helix-turn-helix domains; Region: HTH; cl00088 271065006019 murein transglycosylase C; Provisional; Region: mltC; PRK11671 271065006020 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 271065006021 N-acetyl-D-glucosamine binding site [chemical binding]; other site 271065006022 catalytic residue [active] 271065006023 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 271065006024 ligand binding site [chemical binding]; other site 271065006025 flexible hinge region; other site 271065006026 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 271065006027 sulfate transport protein; Provisional; Region: cysT; CHL00187 271065006028 hypothetical protein; Provisional; Region: PRK02250 271065006029 SEC-C motif; Region: SEC-C; pfam02810 271065006030 TIGR03440 family protein; Region: unchr_TIGR03440 271065006031 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 271065006032 probable methyltransferase; Region: TIGR03438 271065006033 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 271065006034 Domain of unknown function (DUF427); Region: DUF427; cl00998 271065006035 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 271065006036 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 271065006037 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 271065006038 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 271065006039 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 271065006040 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 271065006041 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 271065006042 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 271065006043 Ligand binding site; other site 271065006044 metal-binding site 271065006045 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 271065006046 XdhC Rossmann domain; Region: XdhC_C; pfam13478 271065006047 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 271065006048 metal binding site 2 [ion binding]; metal-binding site 271065006049 putative DNA binding helix; other site 271065006050 metal binding site 1 [ion binding]; metal-binding site 271065006051 dimer interface [polypeptide binding]; other site 271065006052 structural Zn2+ binding site [ion binding]; other site 271065006053 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 271065006054 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 271065006055 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065006056 active site 271065006057 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 271065006058 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 271065006059 putative acyl-acceptor binding pocket; other site 271065006060 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271065006061 PAS domain S-box; Region: sensory_box; TIGR00229 271065006062 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271065006063 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065006064 PAS domain; Region: PAS_9; pfam13426 271065006065 putative active site [active] 271065006066 heme pocket [chemical binding]; other site 271065006067 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065006068 metal binding site [ion binding]; metal-binding site 271065006069 active site 271065006070 I-site; other site 271065006071 Sodium:solute symporter family; Region: SSF; cl00456 271065006072 Protein of unknown function (DUF2459); Region: DUF2459; cl09819 271065006073 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 271065006074 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065006075 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 271065006076 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 271065006077 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 271065006078 anti sigma factor interaction site; other site 271065006079 regulatory phosphorylation site [posttranslational modification]; other site 271065006080 Chromate transporter; Region: Chromate_transp; pfam02417 271065006081 Chromate transporter; Region: Chromate_transp; pfam02417 271065006082 NlpC/P60 family; Region: NLPC_P60; cl11438 271065006083 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 271065006084 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 271065006085 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271065006086 ATP binding site [chemical binding]; other site 271065006087 putative Mg++ binding site [ion binding]; other site 271065006088 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271065006089 nucleotide binding region [chemical binding]; other site 271065006090 ATP-binding site [chemical binding]; other site 271065006091 TRCF domain; Region: TRCF; cl04088 271065006092 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 271065006093 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 271065006094 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 271065006095 catalytic site [active] 271065006096 active site 271065006097 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 271065006098 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 271065006099 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 271065006100 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 271065006101 active site 271065006102 catalytic site [active] 271065006103 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 271065006104 Predicted membrane protein [Function unknown]; Region: COG3174 271065006105 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 271065006106 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 271065006107 dimer interface [polypeptide binding]; other site 271065006108 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 271065006109 metal binding site [ion binding]; metal-binding site 271065006110 exonuclease I; Provisional; Region: sbcB; PRK11779 271065006111 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 271065006112 active site 271065006113 catalytic site [active] 271065006114 substrate binding site [chemical binding]; other site 271065006115 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 271065006116 FOG: CBS domain [General function prediction only]; Region: COG0517 271065006117 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 271065006118 ApbE family; Region: ApbE; cl00643 271065006119 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 271065006120 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 271065006121 catalytic loop [active] 271065006122 iron binding site [ion binding]; other site 271065006123 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 271065006124 FAD binding pocket [chemical binding]; other site 271065006125 FAD binding motif [chemical binding]; other site 271065006126 phosphate binding motif [ion binding]; other site 271065006127 beta-alpha-beta structure motif; other site 271065006128 NAD binding pocket [chemical binding]; other site 271065006129 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 271065006130 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 271065006131 FMN-binding domain; Region: FMN_bind; cl01081 271065006132 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 271065006133 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 271065006134 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 271065006135 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 271065006136 E3 interaction surface; other site 271065006137 lipoyl attachment site [posttranslational modification]; other site 271065006138 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 271065006139 Quinolinate synthetase A protein; Region: NadA; cl00420 271065006140 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 271065006141 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 271065006142 dimer interface [polypeptide binding]; other site 271065006143 anticodon binding site; other site 271065006144 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 271065006145 homodimer interface [polypeptide binding]; other site 271065006146 motif 1; other site 271065006147 active site 271065006148 motif 2; other site 271065006149 GAD domain; Region: GAD; pfam02938 271065006150 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 271065006151 active site 271065006152 motif 3; other site 271065006153 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 271065006154 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 271065006155 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 271065006156 active site 271065006157 substrate binding pocket [chemical binding]; other site 271065006158 dimer interface [polypeptide binding]; other site 271065006159 Protein of unknown function (DUF502); Region: DUF502; cl01107 271065006160 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 271065006161 nucleotide binding site [chemical binding]; other site 271065006162 substrate binding site [chemical binding]; other site 271065006163 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 271065006164 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 271065006165 chorismate binding enzyme; Region: Chorismate_bind; cl10555 271065006166 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 271065006167 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 271065006168 dimerization interface 3.5A [polypeptide binding]; other site 271065006169 active site 271065006170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 271065006171 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 271065006172 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 271065006173 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 271065006174 TRAM domain; Region: TRAM; cl01282 271065006175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065006176 S-adenosylmethionine binding site [chemical binding]; other site 271065006177 Protein of unknown function (DUF1318); Region: DUF1318; cl01547 271065006178 cysteine synthase B; Region: cysM; TIGR01138 271065006179 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 271065006180 dimer interface [polypeptide binding]; other site 271065006181 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271065006182 catalytic residue [active] 271065006183 NMT1-like family; Region: NMT1_2; cl15260 271065006184 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 271065006185 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 271065006186 GAF domain; Region: GAF; cl15785 271065006187 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065006188 dimer interface [polypeptide binding]; other site 271065006189 phosphorylation site [posttranslational modification] 271065006190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065006191 ATP binding site [chemical binding]; other site 271065006192 Mg2+ binding site [ion binding]; other site 271065006193 G-X-G motif; other site 271065006194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065006195 Response regulator receiver domain; Region: Response_reg; pfam00072 271065006196 active site 271065006197 phosphorylation site [posttranslational modification] 271065006198 intermolecular recognition site; other site 271065006199 dimerization interface [polypeptide binding]; other site 271065006200 PAS domain S-box; Region: sensory_box; TIGR00229 271065006201 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271065006202 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065006203 PAS domain; Region: PAS_9; pfam13426 271065006204 putative active site [active] 271065006205 heme pocket [chemical binding]; other site 271065006206 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065006207 metal binding site [ion binding]; metal-binding site 271065006208 active site 271065006209 I-site; other site 271065006210 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065006211 Protein of unknown function (DUF745); Region: DUF745; pfam05335 271065006212 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065006213 metal binding site [ion binding]; metal-binding site 271065006214 active site 271065006215 I-site; other site 271065006216 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cd00562 271065006217 Haem-binding domain; Region: Haem_bd; pfam14376 271065006218 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 271065006219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065006220 active site 271065006221 ABC-2 type transporter; Region: ABC2_membrane; cl11417 271065006222 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 271065006223 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 271065006224 Walker A/P-loop; other site 271065006225 ATP binding site [chemical binding]; other site 271065006226 Q-loop/lid; other site 271065006227 ABC transporter signature motif; other site 271065006228 Walker B; other site 271065006229 D-loop; other site 271065006230 H-loop/switch region; other site 271065006231 Evidence 4 : Homologs of previously reported genes of unknown function 271065006232 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 271065006233 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 271065006234 Evidence 7 : Gene remnant; Product type e : enzyme 271065006235 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 271065006236 Integrase core domain; Region: rve; cl01316 271065006237 transposase; Provisional; Region: PRK06526 271065006238 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065006239 Walker A motif; other site 271065006240 ATP binding site [chemical binding]; other site 271065006241 Walker B motif; other site 271065006242 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 271065006243 active site 271065006244 catalytic residues [active] 271065006245 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 271065006246 Transposase; Region: DDE_Tnp_ISL3; pfam01610 271065006247 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271065006248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065006249 short chain dehydrogenase; Provisional; Region: PRK06198 271065006250 NAD(P) binding site [chemical binding]; other site 271065006251 active site 271065006252 Methyltransferase domain; Region: Methyltransf_31; pfam13847 271065006253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065006254 S-adenosylmethionine binding site [chemical binding]; other site 271065006255 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048 271065006256 diiron binding motif [ion binding]; other site 271065006257 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 271065006258 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065006259 Walker A/P-loop; other site 271065006260 ATP binding site [chemical binding]; other site 271065006261 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 271065006262 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 271065006263 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271065006264 FeoA domain; Region: FeoA; cl00838 271065006265 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 271065006266 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 271065006267 G1 box; other site 271065006268 GTP/Mg2+ binding site [chemical binding]; other site 271065006269 Switch I region; other site 271065006270 G2 box; other site 271065006271 G3 box; other site 271065006272 Switch II region; other site 271065006273 G4 box; other site 271065006274 G5 box; other site 271065006275 Nucleoside recognition; Region: Gate; cl00486 271065006276 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 271065006277 Nucleoside recognition; Region: Gate; cl00486 271065006278 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 271065006279 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271065006280 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 271065006281 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 271065006282 active site residue [active] 271065006283 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 271065006284 NMT1-like family; Region: NMT1_2; cl15260 271065006285 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 271065006286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271065006287 dimer interface [polypeptide binding]; other site 271065006288 conserved gate region; other site 271065006289 putative PBP binding loops; other site 271065006290 ABC-ATPase subunit interface; other site 271065006291 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 271065006292 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 271065006293 Walker A/P-loop; other site 271065006294 ATP binding site [chemical binding]; other site 271065006295 Q-loop/lid; other site 271065006296 ABC transporter signature motif; other site 271065006297 Walker B; other site 271065006298 D-loop; other site 271065006299 H-loop/switch region; other site 271065006300 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 271065006301 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 271065006302 Walker A/P-loop; other site 271065006303 ATP binding site [chemical binding]; other site 271065006304 Q-loop/lid; other site 271065006305 ABC transporter signature motif; other site 271065006306 Walker B; other site 271065006307 D-loop; other site 271065006308 H-loop/switch region; other site 271065006309 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 271065006310 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271065006311 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 271065006312 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 271065006313 [4Fe-4S] binding site [ion binding]; other site 271065006314 molybdopterin cofactor binding site; other site 271065006315 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 271065006316 molybdopterin cofactor binding site; other site 271065006317 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 271065006318 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 271065006319 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 271065006320 active site 271065006321 barstar interaction site; other site 271065006322 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 271065006323 putative RNAase interaction site [polypeptide binding]; other site 271065006324 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 271065006325 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065006326 Family description; Region: UvrD_C_2; cl15862 271065006327 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 271065006328 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 271065006329 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 271065006330 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 271065006331 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 271065006332 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 271065006333 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 271065006334 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 271065006335 DsbD alpha interface [polypeptide binding]; other site 271065006336 catalytic residues [active] 271065006337 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 271065006338 catalytic residues [active] 271065006339 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 271065006340 trimer interface [polypeptide binding]; other site 271065006341 active site 271065006342 dimer interface [polypeptide binding]; other site 271065006343 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 271065006344 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 271065006345 carboxyltransferase (CT) interaction site; other site 271065006346 biotinylation site [posttranslational modification]; other site 271065006347 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 271065006348 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 271065006349 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271065006350 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 271065006351 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 271065006352 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065006353 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 271065006354 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 271065006355 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 271065006356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065006357 S-adenosylmethionine binding site [chemical binding]; other site 271065006358 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 271065006359 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 271065006360 FMN binding site [chemical binding]; other site 271065006361 active site 271065006362 catalytic residues [active] 271065006363 substrate binding site [chemical binding]; other site 271065006364 Helix-turn-helix domains; Region: HTH; cl00088 271065006365 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 271065006366 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 271065006367 purine monophosphate binding site [chemical binding]; other site 271065006368 dimer interface [polypeptide binding]; other site 271065006369 putative catalytic residues [active] 271065006370 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 271065006371 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 271065006372 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 271065006373 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 271065006374 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271065006375 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 271065006376 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 271065006377 FtsX-like permease family; Region: FtsX; cl15850 271065006378 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 271065006379 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065006380 Walker A/P-loop; other site 271065006381 ATP binding site [chemical binding]; other site 271065006382 Q-loop/lid; other site 271065006383 ABC transporter signature motif; other site 271065006384 Walker B; other site 271065006385 D-loop; other site 271065006386 H-loop/switch region; other site 271065006387 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 271065006388 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 271065006389 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 271065006390 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 271065006391 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 271065006392 P loop; other site 271065006393 GTP binding site [chemical binding]; other site 271065006394 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 271065006395 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 271065006396 Subunit III/VIIa interface [polypeptide binding]; other site 271065006397 Phospholipid binding site [chemical binding]; other site 271065006398 Subunit I/III interface [polypeptide binding]; other site 271065006399 Subunit III/VIb interface [polypeptide binding]; other site 271065006400 Subunit III/VIa interface; other site 271065006401 Subunit III/Vb interface [polypeptide binding]; other site 271065006402 Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; cl01240 271065006403 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 271065006404 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 271065006405 Subunit I/III interface [polypeptide binding]; other site 271065006406 D-pathway; other site 271065006407 Subunit I/VIIc interface [polypeptide binding]; other site 271065006408 Subunit I/IV interface [polypeptide binding]; other site 271065006409 Subunit I/II interface [polypeptide binding]; other site 271065006410 Low-spin heme (heme a) binding site [chemical binding]; other site 271065006411 Subunit I/VIIa interface [polypeptide binding]; other site 271065006412 Subunit I/VIa interface [polypeptide binding]; other site 271065006413 Dimer interface; other site 271065006414 Putative water exit pathway; other site 271065006415 Binuclear center (heme a3/CuB) [ion binding]; other site 271065006416 K-pathway; other site 271065006417 Subunit I/Vb interface [polypeptide binding]; other site 271065006418 Putative proton exit pathway; other site 271065006419 Subunit I/VIb interface; other site 271065006420 Subunit I/VIc interface [polypeptide binding]; other site 271065006421 Electron transfer pathway; other site 271065006422 Subunit I/VIIIb interface [polypeptide binding]; other site 271065006423 Subunit I/VIIb interface [polypeptide binding]; other site 271065006424 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 271065006425 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271065006426 Cytochrome c; Region: Cytochrom_C; cl11414 271065006427 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 271065006428 octamerization interface [polypeptide binding]; other site 271065006429 diferric-oxygen binding site [ion binding]; other site 271065006430 AAA domain; Region: AAA_26; pfam13500 271065006431 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065006432 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065006433 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 271065006434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065006435 S-adenosylmethionine binding site [chemical binding]; other site 271065006436 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271065006437 putative pimeloyl-BioC--CoA transferase BioH; Region: bioH; TIGR01738 271065006438 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 271065006439 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 271065006440 substrate-cofactor binding pocket; other site 271065006441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271065006442 catalytic residue [active] 271065006443 biotin synthase; Region: bioB; TIGR00433 271065006444 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271065006445 FeS/SAM binding site; other site 271065006446 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 271065006447 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 271065006448 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 271065006449 active site 271065006450 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 271065006451 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065006452 Walker A motif; other site 271065006453 ATP binding site [chemical binding]; other site 271065006454 Walker B motif; other site 271065006455 arginine finger; other site 271065006456 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 271065006457 HSP70 interaction site [polypeptide binding]; other site 271065006458 Sel1 repeat; Region: Sel1; cl02723 271065006459 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 271065006460 Sel1 repeat; Region: Sel1; cl02723 271065006461 Sel1 repeat; Region: Sel1; cl02723 271065006462 Sel1 repeat; Region: Sel1; cl02723 271065006463 Sel1 repeat; Region: Sel1; cl02723 271065006464 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 271065006465 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 271065006466 NAD binding site [chemical binding]; other site 271065006467 substrate binding site [chemical binding]; other site 271065006468 homodimer interface [polypeptide binding]; other site 271065006469 active site 271065006470 ABC-2 type transporter; Region: ABC2_membrane; cl11417 271065006471 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 271065006472 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065006473 Walker A/P-loop; other site 271065006474 ATP binding site [chemical binding]; other site 271065006475 Q-loop/lid; other site 271065006476 ABC transporter signature motif; other site 271065006477 Walker B; other site 271065006478 D-loop; other site 271065006479 H-loop/switch region; other site 271065006480 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 271065006481 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 271065006482 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 271065006483 structural tetrad; other site 271065006484 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 271065006485 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 271065006486 ligand binding site [chemical binding]; other site 271065006487 PilZ domain; Region: PilZ; cl01260 271065006488 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 271065006489 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 271065006490 MOSC domain; Region: MOSC; pfam03473 271065006491 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 271065006492 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 271065006493 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 271065006494 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 271065006495 active site 271065006496 HIGH motif; other site 271065006497 nucleotide binding site [chemical binding]; other site 271065006498 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 271065006499 KMSKS motif; other site 271065006500 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 271065006501 CHASE domain; Region: CHASE; cl01369 271065006502 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271065006503 PAS domain S-box; Region: sensory_box; TIGR00229 271065006504 GAF domain; Region: GAF_2; pfam13185 271065006505 GAF domain; Region: GAF; cl15785 271065006506 putative diguanylate cyclase; Provisional; Region: PRK09776 271065006507 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 271065006508 PAS domain S-box; Region: sensory_box; TIGR00229 271065006509 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065006510 putative active site [active] 271065006511 heme pocket [chemical binding]; other site 271065006512 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065006513 PAS domain; Region: PAS_9; pfam13426 271065006514 putative active site [active] 271065006515 heme pocket [chemical binding]; other site 271065006516 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065006517 metal binding site [ion binding]; metal-binding site 271065006518 active site 271065006519 I-site; other site 271065006520 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065006521 pyruvate carboxylase subunit A; Validated; Region: PRK07178 271065006522 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 271065006523 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271065006524 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 271065006525 pyruvate carboxylase subunit B; Validated; Region: PRK09282 271065006526 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 271065006527 active site 271065006528 catalytic residues [active] 271065006529 metal binding site [ion binding]; metal-binding site 271065006530 homodimer binding site [polypeptide binding]; other site 271065006531 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 271065006532 carboxyltransferase (CT) interaction site; other site 271065006533 biotinylation site [posttranslational modification]; other site 271065006534 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 271065006535 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 271065006536 phosphate acetyltransferase; Reviewed; Region: PRK05632 271065006537 DRTGG domain; Region: DRTGG; cl12147 271065006538 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 271065006539 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 271065006540 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 271065006541 Protein export membrane protein; Region: SecD_SecF; cl14618 271065006542 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 271065006543 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271065006544 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271065006545 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 271065006546 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 271065006547 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 271065006548 putative active site [active] 271065006549 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 271065006550 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 271065006551 Domain of unknown function (DUF4071); Region: DUF4071; pfam13281 271065006552 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 271065006553 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 271065006554 active site 271065006555 nucleophile elbow; other site 271065006556 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 271065006557 Domain of unknown function (DUF4071); Region: DUF4071; pfam13281 271065006558 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 271065006559 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 271065006560 Transposase IS200 like; Region: Y1_Tnp; cl00848 271065006561 AIPR protein; Region: AIPR; pfam10592 271065006562 Winged helix-turn helix; Region: HTH_29; pfam13551 271065006563 Helix-turn-helix domains; Region: HTH; cl00088 271065006564 Integrase core domain; Region: rve; cl01316 271065006565 Integrase core domain; Region: rve_3; cl15866 271065006566 Helix-turn-helix domains; Region: HTH; cl00088 271065006567 rod shape-determining protein MreC; Provisional; Region: PRK13922 271065006568 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10393315, 12549933, 12860127, 20068850, 10739946, 20245547, 20347927; Product type e : enzyme 271065006569 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10393315, 12549933, 12860127, 20068850, 10739946, 20245547, 20347927; Product type e : enzyme 271065006570 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 271065006571 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 271065006572 trimerization site [polypeptide binding]; other site 271065006573 active site 271065006574 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 271065006575 NifU-like domain; Region: NifU; cl00484 271065006576 NifZ domain; Region: NifZ; pfam04319 271065006577 Helix-turn-helix domains; Region: HTH; cl00088 271065006578 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 271065006579 TOBE domain; Region: TOBE_2; cl01440 271065006580 TOBE domain; Region: TOBE_2; cl01440 271065006581 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 271065006582 Helix-turn-helix domains; Region: HTH; cl00088 271065006583 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 271065006584 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271065006585 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 271065006586 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271065006587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271065006588 dimer interface [polypeptide binding]; other site 271065006589 conserved gate region; other site 271065006590 putative PBP binding loops; other site 271065006591 ABC-ATPase subunit interface; other site 271065006592 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 271065006593 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065006594 Walker A/P-loop; other site 271065006595 ATP binding site [chemical binding]; other site 271065006596 Q-loop/lid; other site 271065006597 ABC transporter signature motif; other site 271065006598 Walker B; other site 271065006599 D-loop; other site 271065006600 H-loop/switch region; other site 271065006601 TOBE domain; Region: TOBE_2; cl01440 271065006602 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 271065006603 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 271065006604 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 271065006605 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 271065006606 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 271065006607 substrate binding site [chemical binding]; other site 271065006608 ATP binding site [chemical binding]; other site 271065006609 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 271065006610 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 271065006611 lipoyl attachment site [posttranslational modification]; other site 271065006612 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 271065006613 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 271065006614 Protein export membrane protein; Region: SecD_SecF; cl14618 271065006615 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 271065006616 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 271065006617 methyl-accepting protein IV; Provisional; Region: PRK09793 271065006618 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271065006619 dimer interface [polypeptide binding]; other site 271065006620 putative CheW interface [polypeptide binding]; other site 271065006621 NMT1/THI5 like; Region: NMT1; pfam09084 271065006622 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 271065006623 substrate binding pocket [chemical binding]; other site 271065006624 membrane-bound complex binding site; other site 271065006625 hinge residues; other site 271065006626 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 271065006627 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271065006628 substrate binding pocket [chemical binding]; other site 271065006629 membrane-bound complex binding site; other site 271065006630 hinge residues; other site 271065006631 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271065006632 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 271065006633 substrate binding pocket [chemical binding]; other site 271065006634 membrane-bound complex binding site; other site 271065006635 hinge residues; other site 271065006636 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065006637 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 271065006638 putative active site [active] 271065006639 heme pocket [chemical binding]; other site 271065006640 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065006641 dimer interface [polypeptide binding]; other site 271065006642 phosphorylation site [posttranslational modification] 271065006643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065006644 ATP binding site [chemical binding]; other site 271065006645 Mg2+ binding site [ion binding]; other site 271065006646 G-X-G motif; other site 271065006647 Response regulator receiver domain; Region: Response_reg; pfam00072 271065006648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065006649 active site 271065006650 phosphorylation site [posttranslational modification] 271065006651 intermolecular recognition site; other site 271065006652 dimerization interface [polypeptide binding]; other site 271065006653 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 271065006654 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065006655 active site 271065006656 phosphorylation site [posttranslational modification] 271065006657 intermolecular recognition site; other site 271065006658 dimerization interface [polypeptide binding]; other site 271065006659 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 271065006660 Zn2+ binding site [ion binding]; other site 271065006661 Mg2+ binding site [ion binding]; other site 271065006662 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 271065006663 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271065006664 substrate binding pocket [chemical binding]; other site 271065006665 membrane-bound complex binding site; other site 271065006666 hinge residues; other site 271065006667 PAS domain S-box; Region: sensory_box; TIGR00229 271065006668 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065006669 putative active site [active] 271065006670 heme pocket [chemical binding]; other site 271065006671 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065006672 metal binding site [ion binding]; metal-binding site 271065006673 active site 271065006674 I-site; other site 271065006675 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065006676 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 271065006677 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 271065006678 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 271065006679 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 271065006680 transmembrane helices; other site 271065006681 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 271065006682 putative transporter; Validated; Region: PRK03818 271065006683 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 271065006684 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 271065006685 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 271065006686 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 271065006687 Peptidase family M48; Region: Peptidase_M48; cl12018 271065006688 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 271065006689 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 271065006690 putative ATP binding site [chemical binding]; other site 271065006691 putative substrate interface [chemical binding]; other site 271065006692 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 271065006693 active site 271065006694 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 271065006695 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 271065006696 dimer interface [polypeptide binding]; other site 271065006697 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271065006698 catalytic residue [active] 271065006699 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 271065006700 nucleotide binding site/active site [active] 271065006701 HIT family signature motif; other site 271065006702 catalytic residue [active] 271065006703 recombination protein RecR; Reviewed; Region: recR; PRK00076 271065006704 RecR protein; Region: RecR; pfam02132 271065006705 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 271065006706 putative active site [active] 271065006707 putative metal-binding site [ion binding]; other site 271065006708 tetramer interface [polypeptide binding]; other site 271065006709 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 271065006710 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14969 271065006711 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065006712 Walker A motif; other site 271065006713 ATP binding site [chemical binding]; other site 271065006714 Walker B motif; other site 271065006715 arginine finger; other site 271065006716 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 271065006717 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 271065006718 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 271065006719 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 271065006720 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065006721 dimer interface [polypeptide binding]; other site 271065006722 phosphorylation site [posttranslational modification] 271065006723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065006724 ATP binding site [chemical binding]; other site 271065006725 Mg2+ binding site [ion binding]; other site 271065006726 G-X-G motif; other site 271065006727 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 271065006728 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271065006729 DNA binding residues [nucleotide binding] 271065006730 dimerization interface [polypeptide binding]; other site 271065006731 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271065006732 Helix-turn-helix domains; Region: HTH; cl00088 271065006733 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 271065006734 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 271065006735 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 271065006736 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271065006737 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271065006738 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 271065006739 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 271065006740 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 271065006741 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 271065006742 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065006743 dimer interface [polypeptide binding]; other site 271065006744 phosphorylation site [posttranslational modification] 271065006745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065006746 ATP binding site [chemical binding]; other site 271065006747 Mg2+ binding site [ion binding]; other site 271065006748 G-X-G motif; other site 271065006749 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 271065006750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065006751 active site 271065006752 phosphorylation site [posttranslational modification] 271065006753 intermolecular recognition site; other site 271065006754 dimerization interface [polypeptide binding]; other site 271065006755 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271065006756 DNA binding site [nucleotide binding] 271065006757 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 271065006758 active site clefts [active] 271065006759 zinc binding site [ion binding]; other site 271065006760 dimer interface [polypeptide binding]; other site 271065006761 Sulfate transporter family; Region: Sulfate_transp; cl15842 271065006762 Sulfate transporter family; Region: Sulfate_transp; cl15842 271065006763 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 271065006764 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 271065006765 Ligand Binding Site [chemical binding]; other site 271065006766 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 271065006767 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 271065006768 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 271065006769 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 271065006770 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271065006771 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 271065006772 Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907 271065006773 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 271065006774 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 271065006775 Predicted ATP-dependent carboligase related to biotin carboxylase [General function prediction only]; Region: COG2232 271065006776 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271065006777 N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264 271065006778 Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria. It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545 271065006779 trimer interface I [polypeptide binding]; other site 271065006780 putative substrate binding pocket [chemical binding]; other site 271065006781 trimer interface II [polypeptide binding]; other site 271065006782 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 271065006783 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271065006784 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 271065006785 Formaldehyde-activating enzyme (Fae); Region: Fae; cl00774 271065006786 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 271065006787 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 271065006788 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 271065006789 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 271065006790 active site 271065006791 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723 271065006792 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 271065006793 active site 271065006794 Predicted ATP-utilizing enzyme (ATP-grasp superfamily) [General function prediction only]; Region: COG1821 271065006795 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271065006796 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 271065006797 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 271065006798 alanine racemase; Reviewed; Region: alr; PRK00053 271065006799 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 271065006800 active site 271065006801 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 271065006802 substrate binding site [chemical binding]; other site 271065006803 catalytic residues [active] 271065006804 dimer interface [polypeptide binding]; other site 271065006805 replicative DNA helicase; Region: DnaB; TIGR00665 271065006806 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 271065006807 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 271065006808 Walker A motif; other site 271065006809 ATP binding site [chemical binding]; other site 271065006810 Walker B motif; other site 271065006811 DNA binding loops [nucleotide binding] 271065006812 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 271065006813 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 271065006814 active site 271065006815 HIGH motif; other site 271065006816 dimer interface [polypeptide binding]; other site 271065006817 KMSKS motif; other site 271065006818 PilZ domain; Region: PilZ; cl01260 271065006819 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 271065006820 active site 271065006821 Protein of unknown function (DUF1249); Region: DUF1249; cl01223 271065006822 Helix-turn-helix domains; Region: HTH; cl00088 271065006823 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 271065006824 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 271065006825 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 271065006826 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271065006827 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271065006828 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 271065006829 AAA domain; Region: AAA_32; pfam13654 271065006830 lon-related putative ATP-dependent protease; Region: lon_rel; TIGR00764 271065006831 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 271065006832 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065006833 PAS domain; Region: PAS_9; pfam13426 271065006834 putative active site [active] 271065006835 heme pocket [chemical binding]; other site 271065006836 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065006837 metal binding site [ion binding]; metal-binding site 271065006838 active site 271065006839 I-site; other site 271065006840 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065006841 PAS fold; Region: PAS_3; pfam08447 271065006842 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065006843 putative active site [active] 271065006844 heme pocket [chemical binding]; other site 271065006845 PAS domain; Region: PAS_9; pfam13426 271065006846 Histidine kinase; Region: HisKA_2; cl06527 271065006847 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065006848 ATP binding site [chemical binding]; other site 271065006849 Mg2+ binding site [ion binding]; other site 271065006850 G-X-G motif; other site 271065006851 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 271065006852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065006853 active site 271065006854 phosphorylation site [posttranslational modification] 271065006855 intermolecular recognition site; other site 271065006856 dimerization interface [polypeptide binding]; other site 271065006857 ANTAR domain; Region: ANTAR; cl04297 271065006858 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271065006859 PAS fold; Region: PAS_4; pfam08448 271065006860 PAS domain S-box; Region: sensory_box; TIGR00229 271065006861 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065006862 putative active site [active] 271065006863 heme pocket [chemical binding]; other site 271065006864 GAF domain; Region: GAF; cl15785 271065006865 GAF domain; Region: GAF_2; pfam13185 271065006866 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065006867 PAS domain; Region: PAS_9; pfam13426 271065006868 putative active site [active] 271065006869 heme pocket [chemical binding]; other site 271065006870 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065006871 metal binding site [ion binding]; metal-binding site 271065006872 active site 271065006873 I-site; other site 271065006874 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065006875 CheB methylesterase; Region: CheB_methylest; pfam01339 271065006876 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 271065006877 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 271065006878 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065006879 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 271065006880 PAS domain; Region: PAS_10; pfam13596 271065006881 PAS fold; Region: PAS_4; pfam08448 271065006882 PAS fold; Region: PAS; pfam00989 271065006883 CHASE domain; Region: CHASE; cl01369 271065006884 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271065006885 PAS fold; Region: PAS_3; pfam08447 271065006886 putative active site [active] 271065006887 heme pocket [chemical binding]; other site 271065006888 PAS domain S-box; Region: sensory_box; TIGR00229 271065006889 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065006890 putative active site [active] 271065006891 heme pocket [chemical binding]; other site 271065006892 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065006893 PAS fold; Region: PAS_4; pfam08448 271065006894 putative active site [active] 271065006895 heme pocket [chemical binding]; other site 271065006896 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065006897 PAS domain; Region: PAS_9; pfam13426 271065006898 putative active site [active] 271065006899 heme pocket [chemical binding]; other site 271065006900 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065006901 dimer interface [polypeptide binding]; other site 271065006902 phosphorylation site [posttranslational modification] 271065006903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065006904 ATP binding site [chemical binding]; other site 271065006905 Mg2+ binding site [ion binding]; other site 271065006906 G-X-G motif; other site 271065006907 Response regulator receiver domain; Region: Response_reg; pfam00072 271065006908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065006909 active site 271065006910 phosphorylation site [posttranslational modification] 271065006911 intermolecular recognition site; other site 271065006912 dimerization interface [polypeptide binding]; other site 271065006913 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 271065006914 putative binding surface; other site 271065006915 active site 271065006916 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 271065006917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065006918 active site 271065006919 phosphorylation site [posttranslational modification] 271065006920 intermolecular recognition site; other site 271065006921 dimerization interface [polypeptide binding]; other site 271065006922 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 271065006923 Zn2+ binding site [ion binding]; other site 271065006924 Mg2+ binding site [ion binding]; other site 271065006925 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 271065006926 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 271065006927 NAD binding site [chemical binding]; other site 271065006928 homodimer interface [polypeptide binding]; other site 271065006929 active site 271065006930 putative substrate binding site [chemical binding]; other site 271065006931 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 271065006932 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 271065006933 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271065006934 catalytic residue [active] 271065006935 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 271065006936 homodimer interface [polypeptide binding]; other site 271065006937 Walker A motif; other site 271065006938 ATP binding site [chemical binding]; other site 271065006939 hydroxycobalamin binding site [chemical binding]; other site 271065006940 Walker B motif; other site 271065006941 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271065006942 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 271065006943 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271065006944 Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066 271065006945 nickel binding site [ion binding]; other site 271065006946 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 271065006947 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065006948 PAS domain; Region: PAS_9; pfam13426 271065006949 putative active site [active] 271065006950 heme pocket [chemical binding]; other site 271065006951 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 271065006952 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 271065006953 G1 box; other site 271065006954 GTP/Mg2+ binding site [chemical binding]; other site 271065006955 G2 box; other site 271065006956 Switch I region; other site 271065006957 G3 box; other site 271065006958 Switch II region; other site 271065006959 G4 box; other site 271065006960 G5 box; other site 271065006961 Sporulation related domain; Region: SPOR; cl10051 271065006962 Late embryogenesis abundant protein; Region: LEA_2; cl12118 271065006963 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 271065006964 intersubunit interface [polypeptide binding]; other site 271065006965 active site 271065006966 Zn2+ binding site [ion binding]; other site 271065006967 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 271065006968 Cupin domain; Region: Cupin_2; cl09118 271065006969 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 271065006970 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271065006971 motif II; other site 271065006972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 271065006973 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 271065006974 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 271065006975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 271065006976 Peptidase M15; Region: Peptidase_M15_3; cl01194 271065006977 MarC family integral membrane protein; Region: MarC; cl00919 271065006978 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 271065006979 Cation transport protein; Region: TrkH; cl10514 271065006980 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 271065006981 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065006982 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 271065006983 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 271065006984 Cation transport protein; Region: TrkH; cl10514 271065006985 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 271065006986 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065006987 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 271065006988 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065006989 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 271065006990 Response regulator receiver domain; Region: Response_reg; pfam00072 271065006991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065006992 active site 271065006993 phosphorylation site [posttranslational modification] 271065006994 intermolecular recognition site; other site 271065006995 dimerization interface [polypeptide binding]; other site 271065006996 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 271065006997 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 271065006998 SprA-related family; Region: SprA-related; pfam12118 271065006999 HerA helicase [Replication, recombination, and repair]; Region: COG0433 271065007000 Domain of unknown function DUF87; Region: DUF87; pfam01935 271065007001 Helix-turn-helix domains; Region: HTH; cl00088 271065007002 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 271065007003 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 271065007004 G1 box; other site 271065007005 GTP/Mg2+ binding site [chemical binding]; other site 271065007006 Switch I region; other site 271065007007 G2 box; other site 271065007008 G3 box; other site 271065007009 Switch II region; other site 271065007010 G4 box; other site 271065007011 G5 box; other site 271065007012 Nucleoside recognition; Region: Gate; cl00486 271065007013 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 271065007014 Nucleoside recognition; Region: Gate; cl00486 271065007015 FeoA domain; Region: FeoA; cl00838 271065007016 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 271065007017 IHF dimer interface [polypeptide binding]; other site 271065007018 IHF - DNA interface [nucleotide binding]; other site 271065007019 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 271065007020 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 271065007021 RNA binding site [nucleotide binding]; other site 271065007022 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 271065007023 RNA binding site [nucleotide binding]; other site 271065007024 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 271065007025 RNA binding site [nucleotide binding]; other site 271065007026 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec4; cd05689 271065007027 RNA binding site [nucleotide binding]; other site 271065007028 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 271065007029 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691 271065007030 RNA binding site [nucleotide binding]; other site 271065007031 cytidylate kinase; Provisional; Region: cmk; PRK00023 271065007032 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 271065007033 CMP-binding site; other site 271065007034 The sites determining sugar specificity; other site 271065007035 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 271065007036 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 271065007037 hinge; other site 271065007038 active site 271065007039 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 271065007040 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065007041 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 271065007042 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271065007043 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271065007044 homodimer interface [polypeptide binding]; other site 271065007045 catalytic residue [active] 271065007046 Chorismate mutase type II; Region: CM_2; cl00693 271065007047 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 271065007048 Prephenate dehydratase; Region: PDT; pfam00800 271065007049 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 271065007050 putative L-Phe binding site [chemical binding]; other site 271065007051 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 271065007052 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 271065007053 homodimer interface [polypeptide binding]; other site 271065007054 substrate-cofactor binding pocket; other site 271065007055 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271065007056 catalytic residue [active] 271065007057 DNA gyrase subunit A; Validated; Region: PRK05560 271065007058 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 271065007059 CAP-like domain; other site 271065007060 active site 271065007061 primary dimer interface [polypeptide binding]; other site 271065007062 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 271065007063 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 271065007064 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 271065007065 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 271065007066 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 271065007067 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 271065007068 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 271065007069 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271065007070 FeS/SAM binding site; other site 271065007071 HemN C-terminal domain; Region: HemN_C; pfam06969 271065007072 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 271065007073 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 271065007074 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271065007075 binding surface 271065007076 TPR motif; other site 271065007077 Cytochrome C biogenesis protein; Region: CcmH; cl01179 271065007078 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 271065007079 catalytic residues [active] 271065007080 central insert; other site 271065007081 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 271065007082 CcmE; Region: CcmE; cl00994 271065007083 Heme exporter protein D (CcmD); Region: CcmD; cl11475 271065007084 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 271065007085 CcmB protein; Region: CcmB; cl01016 271065007086 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065007087 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 271065007088 Walker A/P-loop; other site 271065007089 ATP binding site [chemical binding]; other site 271065007090 Q-loop/lid; other site 271065007091 ABC transporter signature motif; other site 271065007092 Walker B; other site 271065007093 D-loop; other site 271065007094 H-loop/switch region; other site 271065007095 Putative glucoamylase; Region: Glycoamylase; pfam10091 271065007096 Putative carbohydrate binding domain; Region: CBM_X; cl05621 271065007097 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 271065007098 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 271065007099 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 271065007100 Putative carbohydrate binding domain; Region: CBM_X; cl05621 271065007101 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 271065007102 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 271065007103 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 271065007104 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 271065007105 NodB motif; other site 271065007106 active site 271065007107 catalytic site [active] 271065007108 metal binding site [ion binding]; metal-binding site 271065007109 TRL-like protein family; Region: TRL; pfam13146 271065007110 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 271065007111 putative acyl-acceptor binding pocket; other site 271065007112 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 271065007113 Ligand binding site; other site 271065007114 Putative Catalytic site; other site 271065007115 DXD motif; other site 271065007116 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 271065007117 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 271065007118 Active site cavity [active] 271065007119 catalytic acid [active] 271065007120 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 271065007121 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 271065007122 ligand binding site [chemical binding]; other site 271065007123 Helix-turn-helix domains; Region: HTH; cl00088 271065007124 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 271065007125 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 271065007126 ligand binding site [chemical binding]; other site 271065007127 flexible hinge region; other site 271065007128 Helix-turn-helix domains; Region: HTH; cl00088 271065007129 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271065007130 PAS domain; Region: PAS_9; pfam13426 271065007131 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 271065007132 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271065007133 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271065007134 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 271065007135 CsbD-like; Region: CsbD; cl15799 271065007136 CsbD-like; Region: CsbD; cl15799 271065007137 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 271065007138 flagellar motor protein MotB; Validated; Region: motB; PRK05996 271065007139 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271065007140 ligand binding site [chemical binding]; other site 271065007141 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 271065007142 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 271065007143 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 271065007144 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 271065007145 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 271065007146 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 271065007147 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065007148 PAS domain; Region: PAS_9; pfam13426 271065007149 putative active site [active] 271065007150 heme pocket [chemical binding]; other site 271065007151 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065007152 metal binding site [ion binding]; metal-binding site 271065007153 active site 271065007154 I-site; other site 271065007155 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065007156 CheB methylesterase; Region: CheB_methylest; pfam01339 271065007157 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 271065007158 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 271065007159 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065007160 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 271065007161 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 271065007162 PAS domain; Region: PAS_10; pfam13596 271065007163 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 271065007164 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 271065007165 Plant ATP synthase F0; Region: YMF19; cl07975 271065007166 BON domain; Region: BON; cl02771 271065007167 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 271065007168 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271065007169 ligand binding site [chemical binding]; other site 271065007170 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cl00250 271065007171 30S subunit binding site; other site 271065007172 BON domain; Region: BON; cl02771 271065007173 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 271065007174 dinuclear metal binding motif [ion binding]; other site 271065007175 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl08302 271065007176 EF-hand domain pair; Region: EF_hand_5; pfam13499 271065007177 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 271065007178 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 271065007179 Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; cl01558 271065007180 Winged helix-turn helix; Region: HTH_29; pfam13551 271065007181 Helix-turn-helix domains; Region: HTH; cl00088 271065007182 Integrase core domain; Region: rve; cl01316 271065007183 Integrase core domain; Region: rve_3; cl15866 271065007184 Helix-turn-helix domains; Region: HTH; cl00088 271065007185 rod shape-determining protein MreC; Provisional; Region: PRK13922 271065007186 Protein of unknown function (DUF502); Region: DUF502; cl01107 271065007187 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065007188 metal binding site [ion binding]; metal-binding site 271065007189 active site 271065007190 I-site; other site 271065007191 hydroperoxidase II; Provisional; Region: katE; PRK11249 271065007192 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 271065007193 tetramer interface [polypeptide binding]; other site 271065007194 heme binding pocket [chemical binding]; other site 271065007195 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 271065007196 domain interactions; other site 271065007197 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 271065007198 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 271065007199 periplasmic protein; Provisional; Region: PRK10568 271065007200 BON domain; Region: BON; cl02771 271065007201 putative phosphoketolase; Provisional; Region: PRK05261 271065007202 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 271065007203 TPP-binding site; other site 271065007204 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 271065007205 XFP C-terminal domain; Region: XFP_C; pfam09363 271065007206 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 271065007207 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 271065007208 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 271065007209 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 271065007210 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271065007211 active site 271065007212 motif I; other site 271065007213 motif II; other site 271065007214 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 271065007215 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 271065007216 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 271065007217 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 271065007218 Domain of unknown function DUF302; Region: DUF302; cl01364 271065007219 Helix-turn-helix domains; Region: HTH; cl00088 271065007220 rod shape-determining protein MreC; Provisional; Region: PRK13922 271065007221 Winged helix-turn helix; Region: HTH_29; pfam13551 271065007222 Helix-turn-helix domains; Region: HTH; cl00088 271065007223 Integrase core domain; Region: rve; cl01316 271065007224 Integrase core domain; Region: rve_3; cl15866 271065007225 CsbD-like; Region: CsbD; cl15799 271065007226 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065007227 metal binding site [ion binding]; metal-binding site 271065007228 active site 271065007229 I-site; other site 271065007230 BON domain; Region: BON; cl02771 271065007231 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 271065007232 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 271065007233 CsbD-like; Region: CsbD; cl15799 271065007234 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 271065007235 rRNA binding site [nucleotide binding]; other site 271065007236 predicted 30S ribosome binding site; other site 271065007237 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 271065007238 Clp amino terminal domain; Region: Clp_N; pfam02861 271065007239 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065007240 Walker A motif; other site 271065007241 ATP binding site [chemical binding]; other site 271065007242 Walker B motif; other site 271065007243 arginine finger; other site 271065007244 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065007245 Walker A motif; other site 271065007246 ATP binding site [chemical binding]; other site 271065007247 Walker B motif; other site 271065007248 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 271065007249 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 271065007250 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 271065007251 nudix motif; other site 271065007252 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 271065007253 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 271065007254 Ligand Binding Site [chemical binding]; other site 271065007255 adenylosuccinate lyase; Provisional; Region: PRK09285 271065007256 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 271065007257 tetramer interface [polypeptide binding]; other site 271065007258 active site 271065007259 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 271065007260 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 271065007261 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 271065007262 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 271065007263 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 271065007264 Evidence 7 : Gene remnant 271065007265 Evidence 7 : Gene remnant 271065007266 Evidence 7 : Gene remnant 271065007267 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 271065007268 G1 box; other site 271065007269 GTP/Mg2+ binding site [chemical binding]; other site 271065007270 G2 box; other site 271065007271 Switch I region; other site 271065007272 G3 box; other site 271065007273 Switch II region; other site 271065007274 G4 box; other site 271065007275 G5 box; other site 271065007276 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065007277 GTP/Mg2+ binding site [chemical binding]; other site 271065007278 G5 box; other site 271065007279 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065007280 G1 box; other site 271065007281 G1 box; other site 271065007282 GTP/Mg2+ binding site [chemical binding]; other site 271065007283 Switch I region; other site 271065007284 G2 box; other site 271065007285 G2 box; other site 271065007286 Switch I region; other site 271065007287 G3 box; other site 271065007288 Switch II region; other site 271065007289 G4 box; other site 271065007290 Protein of unknown function (DUF2959); Region: DUF2959; pfam11172 271065007291 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 271065007292 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 271065007293 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271065007294 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 271065007295 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 271065007296 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 271065007297 inhibitor site; inhibition site 271065007298 active site 271065007299 dimer interface [polypeptide binding]; other site 271065007300 catalytic residue [active] 271065007301 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 271065007302 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 271065007303 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 271065007304 5-oxoprolinase; Region: PLN02666 271065007305 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 271065007306 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 271065007307 Uncharacterized conserved protein [Function unknown]; Region: COG1912 271065007308 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 271065007309 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 271065007310 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 271065007311 Ligand Binding Site [chemical binding]; other site 271065007312 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 271065007313 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 271065007314 dimer interface [polypeptide binding]; other site 271065007315 active site 271065007316 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 271065007317 active site 1 [active] 271065007318 dimer interface [polypeptide binding]; other site 271065007319 active site 2 [active] 271065007320 lytic murein transglycosylase; Provisional; Region: PRK11619 271065007321 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 271065007322 N-acetyl-D-glucosamine binding site [chemical binding]; other site 271065007323 catalytic residue [active] 271065007324 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 271065007325 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065007326 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 271065007327 Walker A/P-loop; other site 271065007328 ATP binding site [chemical binding]; other site 271065007329 Q-loop/lid; other site 271065007330 ABC transporter signature motif; other site 271065007331 Walker B; other site 271065007332 D-loop; other site 271065007333 H-loop/switch region; other site 271065007334 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 271065007335 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 271065007336 active site 271065007337 Zn binding site [ion binding]; other site 271065007338 Flagellin N-methylase; Region: FliB; cl00497 271065007339 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 271065007340 active site 271065007341 putative catalytic site [active] 271065007342 DNA binding site [nucleotide binding] 271065007343 putative phosphate binding site [ion binding]; other site 271065007344 metal binding site A [ion binding]; metal-binding site 271065007345 AP binding site [nucleotide binding]; other site 271065007346 metal binding site B [ion binding]; metal-binding site 271065007347 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cd09593 271065007348 ligand binding site [chemical binding]; other site 271065007349 active site 271065007350 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 271065007351 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 271065007352 Helix-turn-helix domains; Region: HTH; cl00088 271065007353 rod shape-determining protein MreC; Provisional; Region: PRK13922 271065007354 Winged helix-turn helix; Region: HTH_29; pfam13551 271065007355 Helix-turn-helix domains; Region: HTH; cl00088 271065007356 Integrase core domain; Region: rve; cl01316 271065007357 Integrase core domain; Region: rve_3; cl15866 271065007358 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 271065007359 MASE1; Region: MASE1; pfam05231 271065007360 PAS fold; Region: PAS_4; pfam08448 271065007361 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065007362 putative active site [active] 271065007363 heme pocket [chemical binding]; other site 271065007364 PAS domain S-box; Region: sensory_box; TIGR00229 271065007365 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271065007366 PAS domain S-box; Region: sensory_box; TIGR00229 271065007367 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271065007368 putative active site [active] 271065007369 heme pocket [chemical binding]; other site 271065007370 PAS domain S-box; Region: sensory_box; TIGR00229 271065007371 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065007372 putative active site [active] 271065007373 heme pocket [chemical binding]; other site 271065007374 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 271065007375 dimer interface [polypeptide binding]; other site 271065007376 phosphorylation site [posttranslational modification] 271065007377 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065007378 ATP binding site [chemical binding]; other site 271065007379 Mg2+ binding site [ion binding]; other site 271065007380 G-X-G motif; other site 271065007381 Response regulator receiver domain; Region: Response_reg; pfam00072 271065007382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065007383 active site 271065007384 phosphorylation site [posttranslational modification] 271065007385 intermolecular recognition site; other site 271065007386 dimerization interface [polypeptide binding]; other site 271065007387 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 271065007388 Response regulator receiver domain; Region: Response_reg; pfam00072 271065007389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065007390 active site 271065007391 phosphorylation site [posttranslational modification] 271065007392 intermolecular recognition site; other site 271065007393 dimerization interface [polypeptide binding]; other site 271065007394 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065007395 PAS domain; Region: PAS_9; pfam13426 271065007396 putative active site [active] 271065007397 heme pocket [chemical binding]; other site 271065007398 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065007399 metal binding site [ion binding]; metal-binding site 271065007400 active site 271065007401 I-site; other site 271065007402 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065007403 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 271065007404 CPxP motif; other site 271065007405 siroheme synthase; Provisional; Region: cysG; PRK10637 271065007406 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065007407 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 271065007408 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 271065007409 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 271065007410 structural tetrad; other site 271065007411 Cytochrome c; Region: Cytochrom_C; cl11414 271065007412 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 271065007413 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 271065007414 ANP binding site [chemical binding]; other site 271065007415 Substrate Binding Site II [chemical binding]; other site 271065007416 Substrate Binding Site I [chemical binding]; other site 271065007417 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 271065007418 GIY-YIG motif/motif A; other site 271065007419 putative active site [active] 271065007420 putative metal binding site [ion binding]; other site 271065007421 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 271065007422 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 271065007423 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 271065007424 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 271065007425 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065007426 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 271065007427 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 271065007428 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 271065007429 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 271065007430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065007431 active site 271065007432 phosphorylation site [posttranslational modification] 271065007433 intermolecular recognition site; other site 271065007434 dimerization interface [polypeptide binding]; other site 271065007435 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 271065007436 Zn2+ binding site [ion binding]; other site 271065007437 Mg2+ binding site [ion binding]; other site 271065007438 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 271065007439 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 271065007440 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 271065007441 substrate binding pocket [chemical binding]; other site 271065007442 membrane-bound complex binding site; other site 271065007443 hinge residues; other site 271065007444 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 271065007445 substrate binding pocket [chemical binding]; other site 271065007446 membrane-bound complex binding site; other site 271065007447 hinge residues; other site 271065007448 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 271065007449 dimerization interface [polypeptide binding]; other site 271065007450 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 271065007451 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065007452 dimer interface [polypeptide binding]; other site 271065007453 phosphorylation site [posttranslational modification] 271065007454 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065007455 ATP binding site [chemical binding]; other site 271065007456 Mg2+ binding site [ion binding]; other site 271065007457 G-X-G motif; other site 271065007458 Response regulator receiver domain; Region: Response_reg; pfam00072 271065007459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065007460 active site 271065007461 phosphorylation site [posttranslational modification] 271065007462 intermolecular recognition site; other site 271065007463 dimerization interface [polypeptide binding]; other site 271065007464 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 271065007465 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 271065007466 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 271065007467 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 271065007468 PAS domain S-box; Region: sensory_box; TIGR00229 271065007469 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065007470 putative active site [active] 271065007471 heme pocket [chemical binding]; other site 271065007472 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065007473 metal binding site [ion binding]; metal-binding site 271065007474 active site 271065007475 I-site; other site 271065007476 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065007477 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 271065007478 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 271065007479 active site 271065007480 metal binding site [ion binding]; metal-binding site 271065007481 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 271065007482 SelR domain; Region: SelR; pfam01641 271065007483 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 271065007484 putative ADP-ribose binding site [chemical binding]; other site 271065007485 putative active site [active] 271065007486 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; cl01458 271065007487 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 271065007488 O-Antigen ligase; Region: Wzy_C; cl04850 271065007489 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 271065007490 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 271065007491 homodimer interface [polypeptide binding]; other site 271065007492 substrate-cofactor binding pocket; other site 271065007493 catalytic residue [active] 271065007494 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 271065007495 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 271065007496 metal binding triad; other site 271065007497 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 271065007498 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 271065007499 metal binding triad; other site 271065007500 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 271065007501 ABC-2 type transporter; Region: ABC2_membrane; cl11417 271065007502 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 271065007503 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065007504 Walker A/P-loop; other site 271065007505 ATP binding site [chemical binding]; other site 271065007506 Q-loop/lid; other site 271065007507 ABC transporter signature motif; other site 271065007508 Walker B; other site 271065007509 D-loop; other site 271065007510 H-loop/switch region; other site 271065007511 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 271065007512 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 271065007513 Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; cl11574 271065007514 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 271065007515 Flavin Reductases; Region: FlaRed; cl00801 271065007516 Helix-turn-helix domains; Region: HTH; cl00088 271065007517 rod shape-determining protein MreC; Provisional; Region: PRK13922 271065007518 Winged helix-turn helix; Region: HTH_29; pfam13551 271065007519 Helix-turn-helix domains; Region: HTH; cl00088 271065007520 Integrase core domain; Region: rve; cl01316 271065007521 Integrase core domain; Region: rve_3; cl15866 271065007522 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 271065007523 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 271065007524 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 271065007525 HSP70 interaction site [polypeptide binding]; other site 271065007526 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 271065007527 substrate binding site [polypeptide binding]; other site 271065007528 dimer interface [polypeptide binding]; other site 271065007529 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 271065007530 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 271065007531 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 271065007532 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 271065007533 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065007534 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 271065007535 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 271065007536 putative SdhC subunit interface [polypeptide binding]; other site 271065007537 putative proximal heme binding site [chemical binding]; other site 271065007538 putative Iron-sulfur protein interface [polypeptide binding]; other site 271065007539 putative proximal quinone binding site; other site 271065007540 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 271065007541 Iron-sulfur protein interface; other site 271065007542 proximal quinone binding site [chemical binding]; other site 271065007543 SdhD (CybS) interface [polypeptide binding]; other site 271065007544 proximal heme binding site [chemical binding]; other site 271065007545 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 271065007546 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065007547 metal binding site [ion binding]; metal-binding site 271065007548 active site 271065007549 I-site; other site 271065007550 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 271065007551 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 271065007552 Ligand Binding Site [chemical binding]; other site 271065007553 Molecular Tunnel; other site 271065007554 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 271065007555 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 271065007556 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 271065007557 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 271065007558 active site 271065007559 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 271065007560 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 271065007561 Uncharacterized conserved protein containing a coiled-coil domain [Function unknown]; Region: COG5493 271065007562 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 271065007563 putative active site [active] 271065007564 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 271065007565 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 271065007566 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 271065007567 active site 271065007568 NTP binding site [chemical binding]; other site 271065007569 metal binding triad [ion binding]; metal-binding site 271065007570 antibiotic binding site [chemical binding]; other site 271065007571 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 271065007572 Protein of unknown function DUF86; Region: DUF86; cl01031 271065007573 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065007574 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 271065007575 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 271065007576 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 271065007577 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 271065007578 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653 271065007579 putative active site [active] 271065007580 putative cosubstrate binding site; other site 271065007581 putative substrate binding site [chemical binding]; other site 271065007582 catalytic site [active] 271065007583 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 271065007584 AMP-binding enzyme; Region: AMP-binding; cl15778 271065007585 AMP-binding enzyme; Region: AMP-binding; cl15778 271065007586 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 271065007587 AMP-binding enzyme; Region: AMP-binding; cl15778 271065007588 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 271065007589 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 271065007590 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 271065007591 dimer interface [polypeptide binding]; other site 271065007592 active site 271065007593 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 271065007594 catalytic residues [active] 271065007595 substrate binding site [chemical binding]; other site 271065007596 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 271065007597 MatE; Region: MatE; cl10513 271065007598 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 271065007599 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065007600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065007601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065007602 S-adenosylmethionine binding site [chemical binding]; other site 271065007603 Helix-turn-helix domains; Region: HTH; cl00088 271065007604 potential frameshift: common BLAST hit: gi|344201234|ref|YP_004785560.1| integrase catalytic subunit 271065007605 HTH-like domain; Region: HTH_21; pfam13276 271065007606 Integrase core domain; Region: rve; cl01316 271065007607 Integrase core domain; Region: rve_3; cl15866 271065007608 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 271065007609 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 271065007610 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271065007611 TPR repeat; Region: TPR_11; pfam13414 271065007612 binding surface 271065007613 TPR motif; other site 271065007614 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 271065007615 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 271065007616 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271065007617 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 271065007618 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 271065007619 MatE; Region: MatE; cl10513 271065007620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065007621 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 271065007622 putative homodimer interface [polypeptide binding]; other site 271065007623 O-Antigen ligase; Region: Wzy_C; cl04850 271065007624 potential frameshift: common BLAST hit: gi|30248800|ref|NP_840870.1| capsular polysaccharide biosynthesis protein CapK 271065007625 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 271065007626 AMP-binding enzyme; Region: AMP-binding; cl15778 271065007627 AMP-binding enzyme; Region: AMP-binding; cl15778 271065007628 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 271065007629 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271065007630 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 271065007631 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 271065007632 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 271065007633 putative ADP-binding pocket [chemical binding]; other site 271065007634 Sulfatase; Region: Sulfatase; cl10460 271065007635 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 271065007636 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 271065007637 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 271065007638 inhibitor-cofactor binding pocket; inhibition site 271065007639 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271065007640 catalytic residue [active] 271065007641 Predicted integral membrane protein [Function unknown]; Region: COG0392 271065007642 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 271065007643 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065007644 argininosuccinate lyase; Provisional; Region: PRK02186 271065007645 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271065007646 WbqC-like protein family; Region: WbqC; pfam08889 271065007647 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 271065007648 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 271065007649 Ligand binding site; other site 271065007650 Putative Catalytic site; other site 271065007651 DXD motif; other site 271065007652 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 271065007653 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 271065007654 substrate binding site; other site 271065007655 tetramer interface; other site 271065007656 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 271065007657 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 271065007658 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 271065007659 putative active site [active] 271065007660 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 271065007661 Sulfatase; Region: Sulfatase; cl10460 271065007662 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 271065007663 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 271065007664 Walker A/P-loop; other site 271065007665 ATP binding site [chemical binding]; other site 271065007666 Q-loop/lid; other site 271065007667 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 271065007668 ABC transporter signature motif; other site 271065007669 Walker B; other site 271065007670 D-loop; other site 271065007671 H-loop/switch region; other site 271065007672 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 271065007673 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 271065007674 active site 271065007675 metal binding site [ion binding]; metal-binding site 271065007676 DNA binding site [nucleotide binding] 271065007677 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 271065007678 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 271065007679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065007680 active site 271065007681 phosphorylation site [posttranslational modification] 271065007682 intermolecular recognition site; other site 271065007683 dimerization interface [polypeptide binding]; other site 271065007684 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 271065007685 Response regulator receiver domain; Region: Response_reg; pfam00072 271065007686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065007687 active site 271065007688 phosphorylation site [posttranslational modification] 271065007689 intermolecular recognition site; other site 271065007690 dimerization interface [polypeptide binding]; other site 271065007691 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 271065007692 active site 271065007693 tetramer interface; other site 271065007694 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 271065007695 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 271065007696 Substrate binding site; other site 271065007697 Cupin domain; Region: Cupin_2; cl09118 271065007698 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 271065007699 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 271065007700 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 271065007701 ligand-binding site [chemical binding]; other site 271065007702 UDP-glucose 4-epimerase; Region: PLN02240 271065007703 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 271065007704 NAD binding site [chemical binding]; other site 271065007705 homodimer interface [polypeptide binding]; other site 271065007706 active site 271065007707 substrate binding site [chemical binding]; other site 271065007708 sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013 271065007709 Bacterial sugar transferase; Region: Bac_transf; cl00939 271065007710 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 271065007711 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 271065007712 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 271065007713 Phosphate-selective porin O and P; Region: Porin_O_P; cl01524 271065007714 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 271065007715 MgtE intracellular N domain; Region: MgtE_N; cl15244 271065007716 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 271065007717 Divalent cation transporter; Region: MgtE; cl00786 271065007718 HI0933-like protein; Region: HI0933_like; pfam03486 271065007719 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065007720 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065007721 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 271065007722 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 271065007723 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 271065007724 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271065007725 catalytic residue [active] 271065007726 Helix-turn-helix domains; Region: HTH; cl00088 271065007727 Rrf2 family protein; Region: rrf2_super; TIGR00738 271065007728 serine O-acetyltransferase; Region: cysE; TIGR01172 271065007729 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 271065007730 trimer interface [polypeptide binding]; other site 271065007731 active site 271065007732 substrate binding site [chemical binding]; other site 271065007733 CoA binding site [chemical binding]; other site 271065007734 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 271065007735 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 271065007736 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 271065007737 active site 271065007738 dimerization interface [polypeptide binding]; other site 271065007739 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 271065007740 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 271065007741 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 271065007742 dimer interface [polypeptide binding]; other site 271065007743 active site residues [active] 271065007744 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 271065007745 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 271065007746 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 271065007747 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 271065007748 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 271065007749 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 271065007750 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 271065007751 putative catalytic site [active] 271065007752 putative metal binding site [ion binding]; other site 271065007753 putative phosphate binding site [ion binding]; other site 271065007754 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 271065007755 nudix motif; other site 271065007756 elongation factor P; Provisional; Region: PRK04542 271065007757 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 271065007758 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 271065007759 RNA binding site [nucleotide binding]; other site 271065007760 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 271065007761 RNA binding site [nucleotide binding]; other site 271065007762 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 271065007763 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271065007764 ATP binding site [chemical binding]; other site 271065007765 putative Mg++ binding site [ion binding]; other site 271065007766 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271065007767 nucleotide binding region [chemical binding]; other site 271065007768 ATP-binding site [chemical binding]; other site 271065007769 RQC domain; Region: RQC; cl09632 271065007770 HRDC domain; Region: HRDC; cl02578 271065007771 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl15791 271065007772 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 271065007773 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 271065007774 Active Sites [active] 271065007775 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 271065007776 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 271065007777 dimerization interface [polypeptide binding]; other site 271065007778 domain crossover interface; other site 271065007779 redox-dependent activation switch; other site 271065007780 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 271065007781 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 271065007782 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 271065007783 dimer interface [polypeptide binding]; other site 271065007784 phosphorylation site [posttranslational modification] 271065007785 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065007786 ATP binding site [chemical binding]; other site 271065007787 Mg2+ binding site [ion binding]; other site 271065007788 G-X-G motif; other site 271065007789 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 271065007790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065007791 active site 271065007792 phosphorylation site [posttranslational modification] 271065007793 intermolecular recognition site; other site 271065007794 dimerization interface [polypeptide binding]; other site 271065007795 Helix-turn-helix domains; Region: HTH; cl00088 271065007796 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271065007797 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271065007798 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 271065007799 hypothetical protein; Validated; Region: PRK08223 271065007800 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 271065007801 ATP binding site [chemical binding]; other site 271065007802 substrate interface [chemical binding]; other site 271065007803 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 271065007804 hydrolase; Region: PLN02578 271065007805 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 271065007806 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271065007807 TPR motif; other site 271065007808 TPR repeat; Region: TPR_11; pfam13414 271065007809 binding surface 271065007810 tetratricopeptide repeat protein; Provisional; Region: PRK11788 271065007811 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271065007812 TPR motif; other site 271065007813 binding surface 271065007814 TPR repeat; Region: TPR_11; pfam13414 271065007815 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271065007816 binding surface 271065007817 TPR motif; other site 271065007818 Tetratricopeptide repeat; Region: TPR_16; pfam13432 271065007819 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 271065007820 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 271065007821 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 271065007822 Putative addiction module component; Region: Unstab_antitox; cl09921 271065007823 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 271065007824 putative active site [active] 271065007825 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 271065007826 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 271065007827 Protein of unknown function DUF86; Region: DUF86; cl01031 271065007828 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 271065007829 active site 271065007830 NTP binding site [chemical binding]; other site 271065007831 metal binding triad [ion binding]; metal-binding site 271065007832 antibiotic binding site [chemical binding]; other site 271065007833 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 271065007834 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 271065007835 Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498 271065007836 active site 271065007837 catalytic triad [active] 271065007838 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 271065007839 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 271065007840 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271065007841 binding surface 271065007842 TPR motif; other site 271065007843 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271065007844 binding surface 271065007845 TPR motif; other site 271065007846 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 271065007847 RelB antitoxin; Region: RelB; cl01171 271065007848 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 271065007849 AMIN domain; Region: AMIN; pfam11741 271065007850 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 271065007851 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 271065007852 active site 271065007853 homodimer interface [polypeptide binding]; other site 271065007854 exonuclease subunit SbcC; Provisional; Region: PRK10246 271065007855 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065007856 Walker A/P-loop; other site 271065007857 ATP binding site [chemical binding]; other site 271065007858 Q-loop/lid; other site 271065007859 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065007860 ABC transporter signature motif; other site 271065007861 Walker B; other site 271065007862 D-loop; other site 271065007863 H-loop/switch region; other site 271065007864 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 271065007865 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 271065007866 putative acyl-acceptor binding pocket; other site 271065007867 AMP-binding enzyme; Region: AMP-binding; cl15778 271065007868 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 271065007869 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 271065007870 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 271065007871 polyphosphate kinase; Provisional; Region: PRK05443 271065007872 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 271065007873 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 271065007874 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 271065007875 putative domain interface [polypeptide binding]; other site 271065007876 putative active site [active] 271065007877 catalytic site [active] 271065007878 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 271065007879 putative domain interface [polypeptide binding]; other site 271065007880 putative active site [active] 271065007881 catalytic site [active] 271065007882 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 271065007883 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 271065007884 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065007885 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271065007886 nucleotide binding region [chemical binding]; other site 271065007887 ATP-binding site [chemical binding]; other site 271065007888 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 271065007889 Putative addiction module component; Region: Unstab_antitox; cl09921 271065007890 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 271065007891 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 271065007892 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 271065007893 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 271065007894 HsdM N-terminal domain; Region: HsdM_N; pfam12161 271065007895 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 271065007896 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065007897 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271065007898 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 271065007899 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 271065007900 Global regulator protein family; Region: CsrA; cl00670 271065007901 aspartate kinase; Reviewed; Region: PRK06635 271065007902 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 271065007903 putative nucleotide binding site [chemical binding]; other site 271065007904 putative catalytic residues [active] 271065007905 putative Mg ion binding site [ion binding]; other site 271065007906 putative aspartate binding site [chemical binding]; other site 271065007907 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 271065007908 putative allosteric regulatory site; other site 271065007909 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 271065007910 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 271065007911 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 271065007912 motif 1; other site 271065007913 active site 271065007914 motif 2; other site 271065007915 motif 3; other site 271065007916 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 271065007917 DHHA1 domain; Region: DHHA1; pfam02272 271065007918 RecX family; Region: RecX; cl00936 271065007919 recombinase A; Provisional; Region: recA; PRK09354 271065007920 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 271065007921 hexamer interface [polypeptide binding]; other site 271065007922 Walker A motif; other site 271065007923 ATP binding site [chemical binding]; other site 271065007924 Walker B motif; other site 271065007925 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 271065007926 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 271065007927 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 271065007928 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 271065007929 inhibitor-cofactor binding pocket; inhibition site 271065007930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271065007931 catalytic residue [active] 271065007932 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 271065007933 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065007934 putative phosphoketolase; Provisional; Region: PRK05261 271065007935 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 271065007936 TPP-binding site; other site 271065007937 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 271065007938 XFP C-terminal domain; Region: XFP_C; pfam09363 271065007939 Acetokinase family; Region: Acetate_kinase; cl01029 271065007940 propionate/acetate kinase; Provisional; Region: PRK12379 271065007941 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 271065007942 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 271065007943 putative NAD(P) binding site [chemical binding]; other site 271065007944 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 271065007945 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 271065007946 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 271065007947 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 271065007948 active site 271065007949 homodimer interface [polypeptide binding]; other site 271065007950 catalytic site [active] 271065007951 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 271065007952 fructose-1,6-bisphosphatase family protein; Region: PLN02628 271065007953 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 271065007954 AMP binding site [chemical binding]; other site 271065007955 metal binding site [ion binding]; metal-binding site 271065007956 active site 271065007957 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 271065007958 catalytic triad [active] 271065007959 aminotransferase; Validated; Region: PRK07337 271065007960 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271065007961 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271065007962 homodimer interface [polypeptide binding]; other site 271065007963 catalytic residue [active] 271065007964 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 271065007965 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 271065007966 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 271065007967 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 271065007968 KMSKS motif; other site 271065007969 acetyl-CoA synthetase; Provisional; Region: PRK00174 271065007970 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 271065007971 AMP-binding enzyme; Region: AMP-binding; cl15778 271065007972 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 271065007973 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 271065007974 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 271065007975 Active Sites [active] 271065007976 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 271065007977 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 271065007978 CysD dimerization site [polypeptide binding]; other site 271065007979 G1 box; other site 271065007980 putative GEF interaction site [polypeptide binding]; other site 271065007981 GTP/Mg2+ binding site [chemical binding]; other site 271065007982 Switch I region; other site 271065007983 G2 box; other site 271065007984 G3 box; other site 271065007985 Switch II region; other site 271065007986 G4 box; other site 271065007987 G5 box; other site 271065007988 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 271065007989 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 271065007990 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065007991 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065007992 metal binding site [ion binding]; metal-binding site 271065007993 active site 271065007994 I-site; other site 271065007995 Response regulator receiver domain; Region: Response_reg; pfam00072 271065007996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065007997 active site 271065007998 phosphorylation site [posttranslational modification] 271065007999 intermolecular recognition site; other site 271065008000 dimerization interface [polypeptide binding]; other site 271065008001 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 271065008002 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 271065008003 putative binding surface; other site 271065008004 active site 271065008005 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 271065008006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065008007 ATP binding site [chemical binding]; other site 271065008008 Mg2+ binding site [ion binding]; other site 271065008009 G-X-G motif; other site 271065008010 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 271065008011 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 271065008012 putative CheA interaction surface; other site 271065008013 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065008014 PAS domain; Region: PAS_9; pfam13426 271065008015 putative active site [active] 271065008016 heme pocket [chemical binding]; other site 271065008017 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 271065008018 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271065008019 dimer interface [polypeptide binding]; other site 271065008020 putative CheW interface [polypeptide binding]; other site 271065008021 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 271065008022 putative CheA interaction surface; other site 271065008023 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 271065008024 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 271065008025 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 271065008026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065008027 CheD chemotactic sensory transduction; Region: CheD; cl00810 271065008028 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 271065008029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065008030 active site 271065008031 phosphorylation site [posttranslational modification] 271065008032 intermolecular recognition site; other site 271065008033 dimerization interface [polypeptide binding]; other site 271065008034 CheB methylesterase; Region: CheB_methylest; pfam01339 271065008035 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 271065008036 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271065008037 dimer interface [polypeptide binding]; other site 271065008038 putative CheW interface [polypeptide binding]; other site 271065008039 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 271065008040 anti sigma factor interaction site; other site 271065008041 regulatory phosphorylation site [posttranslational modification]; other site 271065008042 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 271065008043 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 271065008044 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 271065008045 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 271065008046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065008047 Response regulator receiver domain; Region: Response_reg; pfam00072 271065008048 active site 271065008049 phosphorylation site [posttranslational modification] 271065008050 intermolecular recognition site; other site 271065008051 dimerization interface [polypeptide binding]; other site 271065008052 Response regulator receiver domain; Region: Response_reg; pfam00072 271065008053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065008054 active site 271065008055 phosphorylation site [posttranslational modification] 271065008056 intermolecular recognition site; other site 271065008057 dimerization interface [polypeptide binding]; other site 271065008058 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065008059 PAS domain; Region: PAS_9; pfam13426 271065008060 putative active site [active] 271065008061 heme pocket [chemical binding]; other site 271065008062 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065008063 PAS domain; Region: PAS_9; pfam13426 271065008064 putative active site [active] 271065008065 heme pocket [chemical binding]; other site 271065008066 PAS fold; Region: PAS_7; pfam12860 271065008067 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065008068 PAS fold; Region: PAS_3; pfam08447 271065008069 putative active site [active] 271065008070 heme pocket [chemical binding]; other site 271065008071 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 271065008072 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065008073 putative active site [active] 271065008074 heme pocket [chemical binding]; other site 271065008075 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065008076 dimer interface [polypeptide binding]; other site 271065008077 phosphorylation site [posttranslational modification] 271065008078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065008079 ATP binding site [chemical binding]; other site 271065008080 Mg2+ binding site [ion binding]; other site 271065008081 G-X-G motif; other site 271065008082 Response regulator receiver domain; Region: Response_reg; pfam00072 271065008083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065008084 active site 271065008085 phosphorylation site [posttranslational modification] 271065008086 intermolecular recognition site; other site 271065008087 dimerization interface [polypeptide binding]; other site 271065008088 PAS fold; Region: PAS_3; pfam08447 271065008089 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065008090 putative active site [active] 271065008091 heme pocket [chemical binding]; other site 271065008092 PAS domain; Region: PAS_9; pfam13426 271065008093 PAS domain S-box; Region: sensory_box; TIGR00229 271065008094 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065008095 putative active site [active] 271065008096 heme pocket [chemical binding]; other site 271065008097 PAS domain; Region: PAS_9; pfam13426 271065008098 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065008099 putative active site [active] 271065008100 heme pocket [chemical binding]; other site 271065008101 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 271065008102 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065008103 putative active site [active] 271065008104 heme pocket [chemical binding]; other site 271065008105 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065008106 dimer interface [polypeptide binding]; other site 271065008107 phosphorylation site [posttranslational modification] 271065008108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065008109 ATP binding site [chemical binding]; other site 271065008110 Mg2+ binding site [ion binding]; other site 271065008111 G-X-G motif; other site 271065008112 Response regulator receiver domain; Region: Response_reg; pfam00072 271065008113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065008114 active site 271065008115 phosphorylation site [posttranslational modification] 271065008116 intermolecular recognition site; other site 271065008117 dimerization interface [polypeptide binding]; other site 271065008118 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 271065008119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065008120 active site 271065008121 phosphorylation site [posttranslational modification] 271065008122 intermolecular recognition site; other site 271065008123 dimerization interface [polypeptide binding]; other site 271065008124 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 271065008125 Zn2+ binding site [ion binding]; other site 271065008126 Mg2+ binding site [ion binding]; other site 271065008127 GAF domain; Region: GAF_2; pfam13185 271065008128 GAF domain; Region: GAF; cl15785 271065008129 GAF domain; Region: GAF_2; pfam13185 271065008130 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065008131 PAS domain; Region: PAS_9; pfam13426 271065008132 putative active site [active] 271065008133 heme pocket [chemical binding]; other site 271065008134 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271065008135 PAS fold; Region: PAS_3; pfam08447 271065008136 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 271065008137 PAS domain S-box; Region: sensory_box; TIGR00229 271065008138 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065008139 putative active site [active] 271065008140 heme pocket [chemical binding]; other site 271065008141 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065008142 dimer interface [polypeptide binding]; other site 271065008143 phosphorylation site [posttranslational modification] 271065008144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065008145 ATP binding site [chemical binding]; other site 271065008146 Mg2+ binding site [ion binding]; other site 271065008147 G-X-G motif; other site 271065008148 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 271065008149 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 271065008150 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 271065008151 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065008152 PAS fold; Region: PAS_3; pfam08447 271065008153 putative active site [active] 271065008154 heme pocket [chemical binding]; other site 271065008155 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065008156 PAS fold; Region: PAS_3; pfam08447 271065008157 putative active site [active] 271065008158 heme pocket [chemical binding]; other site 271065008159 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065008160 PAS domain; Region: PAS_9; pfam13426 271065008161 putative active site [active] 271065008162 heme pocket [chemical binding]; other site 271065008163 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 271065008164 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065008165 putative active site [active] 271065008166 heme pocket [chemical binding]; other site 271065008167 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065008168 phosphorylation site [posttranslational modification] 271065008169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065008170 ATP binding site [chemical binding]; other site 271065008171 Mg2+ binding site [ion binding]; other site 271065008172 G-X-G motif; other site 271065008173 Response regulator receiver domain; Region: Response_reg; pfam00072 271065008174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065008175 active site 271065008176 phosphorylation site [posttranslational modification] 271065008177 intermolecular recognition site; other site 271065008178 dimerization interface [polypeptide binding]; other site 271065008179 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 271065008180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065008181 active site 271065008182 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 271065008183 phosphorylation site [posttranslational modification] 271065008184 intermolecular recognition site; other site 271065008185 dimerization interface [polypeptide binding]; other site 271065008186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065008187 active site 271065008188 phosphorylation site [posttranslational modification] 271065008189 intermolecular recognition site; other site 271065008190 dimerization interface [polypeptide binding]; other site 271065008191 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065008192 metal binding site [ion binding]; metal-binding site 271065008193 active site 271065008194 I-site; other site 271065008195 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271065008196 Helix-turn-helix domains; Region: HTH; cl00088 271065008197 WHG domain; Region: WHG; pfam13305 271065008198 Helix-turn-helix domains; Region: HTH; cl00088 271065008199 transcriptional activator TtdR; Provisional; Region: PRK09801 271065008200 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271065008201 putative effector binding pocket; other site 271065008202 dimerization interface [polypeptide binding]; other site 271065008203 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 271065008204 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 271065008205 nudix motif; other site 271065008206 Uncharacterized conserved protein [Function unknown]; Region: COG0327 271065008207 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 271065008208 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065008209 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 271065008210 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 271065008211 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 271065008212 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 271065008213 Transcriptional regulators [Transcription]; Region: MarR; COG1846 271065008214 Helix-turn-helix domains; Region: HTH; cl00088 271065008215 Domain of unknown function (DUF2024); Region: DUF2024; pfam09630 271065008216 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 271065008217 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 271065008218 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 271065008219 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 271065008220 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 271065008221 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 271065008222 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065008223 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 271065008224 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 271065008225 Metal-binding active site; metal-binding site 271065008226 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 271065008227 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 271065008228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065008229 ATP binding site [chemical binding]; other site 271065008230 Mg2+ binding site [ion binding]; other site 271065008231 G-X-G motif; other site 271065008232 PAS fold; Region: PAS_3; pfam08447 271065008233 sensory histidine kinase AtoS; Provisional; Region: PRK11360 271065008234 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065008235 dimer interface [polypeptide binding]; other site 271065008236 phosphorylation site [posttranslational modification] 271065008237 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065008238 ATP binding site [chemical binding]; other site 271065008239 Mg2+ binding site [ion binding]; other site 271065008240 G-X-G motif; other site 271065008241 CHASE domain; Region: CHASE; cl01369 271065008242 PAS domain S-box; Region: sensory_box; TIGR00229 271065008243 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065008244 putative active site [active] 271065008245 heme pocket [chemical binding]; other site 271065008246 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065008247 dimer interface [polypeptide binding]; other site 271065008248 phosphorylation site [posttranslational modification] 271065008249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065008250 ATP binding site [chemical binding]; other site 271065008251 Mg2+ binding site [ion binding]; other site 271065008252 G-X-G motif; other site 271065008253 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 271065008254 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 271065008255 HEAT repeats; Region: HEAT_2; pfam13646 271065008256 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 271065008257 tetramer interfaces [polypeptide binding]; other site 271065008258 binuclear metal-binding site [ion binding]; other site 271065008259 thiamine monophosphate kinase; Provisional; Region: PRK05731 271065008260 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 271065008261 ATP binding site [chemical binding]; other site 271065008262 dimerization interface [polypeptide binding]; other site 271065008263 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 271065008264 putative RNA binding site [nucleotide binding]; other site 271065008265 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 271065008266 homopentamer interface [polypeptide binding]; other site 271065008267 active site 271065008268 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 271065008269 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 271065008270 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 271065008271 dimerization interface [polypeptide binding]; other site 271065008272 active site 271065008273 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 271065008274 Lumazine binding domain; Region: Lum_binding; pfam00677 271065008275 Lumazine binding domain; Region: Lum_binding; pfam00677 271065008276 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 271065008277 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 271065008278 catalytic motif [active] 271065008279 Zn binding site [ion binding]; other site 271065008280 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 271065008281 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 271065008282 ATP cone domain; Region: ATP-cone; pfam03477 271065008283 general secretion pathway protein D; Region: type_II_gspD; TIGR02517 271065008284 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 271065008285 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 271065008286 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 271065008287 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 271065008288 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 271065008289 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 271065008290 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 271065008291 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 271065008292 general secretion pathway protein J; Validated; Region: PRK08808 271065008293 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 271065008294 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 271065008295 general secretion pathway protein I; Region: gspI; TIGR01707 271065008296 general secretion pathway protein H; Region: typeII_sec_gspH; TIGR01708 271065008297 Type II transport protein GspH; Region: GspH; pfam12019 271065008298 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 271065008299 general secretion pathway protein G; Region: typeII_sec_gspG; TIGR01710 271065008300 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 271065008301 general secretion pathway protein F; Region: GspF; TIGR02120 271065008302 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 271065008303 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 271065008304 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 271065008305 general secretory pathway protein E; Region: type_II_gspE; TIGR02533 271065008306 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 271065008307 Walker A motif; other site 271065008308 ATP binding site [chemical binding]; other site 271065008309 Walker B motif; other site 271065008310 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271065008311 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 271065008312 putative ADP-binding pocket [chemical binding]; other site 271065008313 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 271065008314 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 271065008315 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 271065008316 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271065008317 Protein of unknown function, DUF482; Region: DUF482; pfam04339 271065008318 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 271065008319 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 271065008320 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271065008321 dimer interface [polypeptide binding]; other site 271065008322 putative CheW interface [polypeptide binding]; other site 271065008323 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 271065008324 putative CheA interaction surface; other site 271065008325 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 271065008326 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 271065008327 putative binding surface; other site 271065008328 active site 271065008329 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 271065008330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065008331 ATP binding site [chemical binding]; other site 271065008332 Mg2+ binding site [ion binding]; other site 271065008333 G-X-G motif; other site 271065008334 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 271065008335 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 271065008336 anti sigma factor interaction site; other site 271065008337 regulatory phosphorylation site [posttranslational modification]; other site 271065008338 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 271065008339 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 271065008340 AAA domain; Region: AAA_33; pfam13671 271065008341 ATP-binding site [chemical binding]; other site 271065008342 Gluconate-6-phosphate binding site [chemical binding]; other site 271065008343 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 271065008344 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 271065008345 active site 271065008346 Peptidase family M48; Region: Peptidase_M48; cl12018 271065008347 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 271065008348 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 271065008349 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 271065008350 active site 271065008351 ATP binding site [chemical binding]; other site 271065008352 substrate binding site [chemical binding]; other site 271065008353 activation loop (A-loop); other site 271065008354 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 271065008355 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 271065008356 phosphopeptide binding site; other site 271065008357 ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with processes...; Region: ABCG_EPDR; cd03213 271065008358 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 271065008359 Walker A/P-loop; other site 271065008360 ATP binding site [chemical binding]; other site 271065008361 Q-loop/lid; other site 271065008362 ABC transporter signature motif; other site 271065008363 Walker B; other site 271065008364 D-loop; other site 271065008365 H-loop/switch region; other site 271065008366 ABC-2 type transporter; Region: ABC2_membrane; cl11417 271065008367 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271065008368 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271065008369 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271065008370 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 271065008371 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 271065008372 dimerization domain [polypeptide binding]; other site 271065008373 dimer interface [polypeptide binding]; other site 271065008374 catalytic residues [active] 271065008375 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 271065008376 zinc metallopeptidase RseP; Provisional; Region: PRK10779 271065008377 active site 271065008378 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 271065008379 protein binding site [polypeptide binding]; other site 271065008380 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 271065008381 putative substrate binding region [chemical binding]; other site 271065008382 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 271065008383 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 271065008384 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 271065008385 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 271065008386 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 271065008387 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 271065008388 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 271065008389 catalytic residue [active] 271065008390 putative FPP diphosphate binding site; other site 271065008391 putative FPP binding hydrophobic cleft; other site 271065008392 dimer interface [polypeptide binding]; other site 271065008393 putative IPP diphosphate binding site; other site 271065008394 ribosome recycling factor; Reviewed; Region: frr; PRK00083 271065008395 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 271065008396 hinge region; other site 271065008397 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 271065008398 putative nucleotide binding site [chemical binding]; other site 271065008399 uridine monophosphate binding site [chemical binding]; other site 271065008400 homohexameric interface [polypeptide binding]; other site 271065008401 elongation factor Ts; Provisional; Region: tsf; PRK09377 271065008402 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 271065008403 Elongation factor TS; Region: EF_TS; pfam00889 271065008404 Elongation factor TS; Region: EF_TS; pfam00889 271065008405 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 271065008406 rRNA interaction site [nucleotide binding]; other site 271065008407 S8 interaction site; other site 271065008408 putative laminin-1 binding site; other site 271065008409 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 271065008410 active site 271065008411 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 271065008412 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 271065008413 metal binding triad; other site 271065008414 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 271065008415 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 271065008416 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 271065008417 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 271065008418 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 271065008419 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271065008420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065008421 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 271065008422 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 271065008423 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 271065008424 active site 271065008425 dimer interface [polypeptide binding]; other site 271065008426 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 271065008427 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 271065008428 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 271065008429 active site 271065008430 FMN binding site [chemical binding]; other site 271065008431 substrate binding site [chemical binding]; other site 271065008432 3Fe-4S cluster binding site [ion binding]; other site 271065008433 Formylmethanofuran dehydrogenase subunit C [Energy production and conversion]; Region: FwdC; COG2218 271065008434 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 271065008435 domain_subunit interface; other site 271065008436 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 271065008437 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 271065008438 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 271065008439 FAD binding pocket [chemical binding]; other site 271065008440 FAD binding motif [chemical binding]; other site 271065008441 catalytic residues [active] 271065008442 NAD binding pocket [chemical binding]; other site 271065008443 phosphate binding motif [ion binding]; other site 271065008444 beta-alpha-beta structure motif; other site 271065008445 ATP-dependent helicase HepA; Validated; Region: PRK04914 271065008446 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271065008447 ATP binding site [chemical binding]; other site 271065008448 putative Mg++ binding site [ion binding]; other site 271065008449 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271065008450 nucleotide binding region [chemical binding]; other site 271065008451 ATP-binding site [chemical binding]; other site 271065008452 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 271065008453 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 271065008454 motif 1; other site 271065008455 dimer interface [polypeptide binding]; other site 271065008456 active site 271065008457 motif 2; other site 271065008458 motif 3; other site 271065008459 elongation factor P; Validated; Region: PRK00529 271065008460 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 271065008461 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 271065008462 RNA binding site [nucleotide binding]; other site 271065008463 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 271065008464 RNA binding site [nucleotide binding]; other site 271065008465 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 271065008466 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 271065008467 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 271065008468 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 271065008469 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 271065008470 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 271065008471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271065008472 putative substrate translocation pore; other site 271065008473 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 271065008474 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271065008475 binding surface 271065008476 TPR motif; other site 271065008477 Tetratricopeptide repeat; Region: TPR_16; pfam13432 271065008478 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271065008479 TPR motif; other site 271065008480 binding surface 271065008481 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271065008482 binding surface 271065008483 TPR motif; other site 271065008484 Tetratricopeptide repeat; Region: TPR_16; pfam13432 271065008485 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 271065008486 binding surface 271065008487 TPR motif; other site 271065008488 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271065008489 binding surface 271065008490 TPR motif; other site 271065008491 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271065008492 binding surface 271065008493 TPR motif; other site 271065008494 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271065008495 Tetratricopeptide repeat; Region: TPR_16; pfam13432 271065008496 binding surface 271065008497 TPR motif; other site 271065008498 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 271065008499 Gram-negative bacterial tonB protein; Region: TonB; cl10048 271065008500 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 271065008501 Domain of unknown function (DUF2341); Region: DUF2341; pfam10102 271065008502 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 271065008503 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 271065008504 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271065008505 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 271065008506 Surface antigen; Region: Bac_surface_Ag; cl03097 271065008507 haemagglutination activity domain; Region: Haemagg_act; cl05436 271065008508 Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545 271065008509 polycystin cation channel protein; Region: PCC; TIGR00864 271065008510 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 271065008511 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 271065008512 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065008513 dimer interface [polypeptide binding]; other site 271065008514 phosphorylation site [posttranslational modification] 271065008515 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065008516 ATP binding site [chemical binding]; other site 271065008517 Mg2+ binding site [ion binding]; other site 271065008518 G-X-G motif; other site 271065008519 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 271065008520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065008521 active site 271065008522 phosphorylation site [posttranslational modification] 271065008523 intermolecular recognition site; other site 271065008524 dimerization interface [polypeptide binding]; other site 271065008525 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271065008526 DNA binding site [nucleotide binding] 271065008527 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 271065008528 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 271065008529 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 271065008530 Clp amino terminal domain; Region: Clp_N; pfam02861 271065008531 Clp amino terminal domain; Region: Clp_N; pfam02861 271065008532 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065008533 Walker A motif; other site 271065008534 ATP binding site [chemical binding]; other site 271065008535 Walker B motif; other site 271065008536 arginine finger; other site 271065008537 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065008538 Walker A motif; other site 271065008539 ATP binding site [chemical binding]; other site 271065008540 Walker B motif; other site 271065008541 arginine finger; other site 271065008542 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 271065008543 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 271065008544 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 271065008545 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 271065008546 Transposase [DNA replication, recombination, and repair]; Region: COG5433 271065008547 Transposase [DNA replication, recombination, and repair]; Region: COG5433 271065008548 Transposase domain (DUF772); Region: DUF772; cl15789 271065008549 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 271065008550 Transposase domain (DUF772); Region: DUF772; cl15789 271065008551 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 271065008552 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 271065008553 Nitrogen regulatory protein P-II; Region: P-II; smart00938 271065008554 FOG: CBS domain [General function prediction only]; Region: COG0517 271065008555 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 271065008556 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 271065008557 DNA-binding site [nucleotide binding]; DNA binding site 271065008558 RNA-binding motif; other site 271065008559 Kelch motif; Region: Kelch_1; cl02701 271065008560 kelch-like protein; Provisional; Region: PHA03098 271065008561 Kelch motif; Region: Kelch_1; cl02701 271065008562 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 271065008563 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 271065008564 N-terminal plug; other site 271065008565 ligand-binding site [chemical binding]; other site 271065008566 Major Facilitator Superfamily; Region: MFS_1; pfam07690 271065008567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 271065008568 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 271065008569 DNA-binding site [nucleotide binding]; DNA binding site 271065008570 RNA-binding motif; other site 271065008571 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 271065008572 Protein of unknown function (DUF3299); Region: DUF3299; cl01387 271065008573 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 271065008574 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 271065008575 Walker A/P-loop; other site 271065008576 ATP binding site [chemical binding]; other site 271065008577 Q-loop/lid; other site 271065008578 ABC transporter signature motif; other site 271065008579 Walker B; other site 271065008580 D-loop; other site 271065008581 H-loop/switch region; other site 271065008582 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 271065008583 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 271065008584 FtsX-like permease family; Region: FtsX; cl15850 271065008585 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 271065008586 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 271065008587 Gram-negative bacterial tonB protein; Region: TonB; cl10048 271065008588 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 271065008589 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 271065008590 alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321 271065008591 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 271065008592 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 271065008593 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 271065008594 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271065008595 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 271065008596 dimer interface [polypeptide binding]; other site 271065008597 Citrate synthase; Region: Citrate_synt; pfam00285 271065008598 active site 271065008599 citrylCoA binding site [chemical binding]; other site 271065008600 NADH binding [chemical binding]; other site 271065008601 cationic pore residues; other site 271065008602 oxalacetate/citrate binding site [chemical binding]; other site 271065008603 coenzyme A binding site [chemical binding]; other site 271065008604 catalytic triad [active] 271065008605 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 271065008606 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 271065008607 substrate binding site [chemical binding]; other site 271065008608 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 271065008609 substrate binding site [chemical binding]; other site 271065008610 ligand binding site [chemical binding]; other site 271065008611 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 271065008612 isocitrate dehydrogenase; Validated; Region: PRK06451 271065008613 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 271065008614 putative active site [active] 271065008615 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 271065008616 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 271065008617 putative hydrolase; Provisional; Region: PRK10985 271065008618 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 271065008619 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 271065008620 ATP binding site [chemical binding]; other site 271065008621 Mg++ binding site [ion binding]; other site 271065008622 motif III; other site 271065008623 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271065008624 nucleotide binding region [chemical binding]; other site 271065008625 ATP-binding site [chemical binding]; other site 271065008626 DbpA RNA binding domain; Region: DbpA; pfam03880 271065008627 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 271065008628 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 271065008629 active site 271065008630 catalytic site [active] 271065008631 substrate binding site [chemical binding]; other site 271065008632 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 271065008633 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271065008634 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 271065008635 Transposase; Region: DDE_Tnp_ISL3; pfam01610 271065008636 MASE1; Region: MASE1; pfam05231 271065008637 CHASE domain; Region: CHASE; cl01369 271065008638 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065008639 PAS domain; Region: PAS_9; pfam13426 271065008640 putative active site [active] 271065008641 heme pocket [chemical binding]; other site 271065008642 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065008643 metal binding site [ion binding]; metal-binding site 271065008644 active site 271065008645 I-site; other site 271065008646 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065008647 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 271065008648 RNA/DNA hybrid binding site [nucleotide binding]; other site 271065008649 active site 271065008650 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065008651 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 271065008652 N-acetyl-D-glucosamine binding site [chemical binding]; other site 271065008653 catalytic residue [active] 271065008654 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 271065008655 putative peptidoglycan binding site; other site 271065008656 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 271065008657 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 271065008658 putative peptidoglycan binding site; other site 271065008659 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 271065008660 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 271065008661 putative peptidoglycan binding site; other site 271065008662 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 271065008663 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 271065008664 Walker A/P-loop; other site 271065008665 ATP binding site [chemical binding]; other site 271065008666 Q-loop/lid; other site 271065008667 ABC transporter signature motif; other site 271065008668 Walker B; other site 271065008669 D-loop; other site 271065008670 H-loop/switch region; other site 271065008671 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 271065008672 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 271065008673 Walker A/P-loop; other site 271065008674 ATP binding site [chemical binding]; other site 271065008675 Q-loop/lid; other site 271065008676 ABC transporter signature motif; other site 271065008677 Walker B; other site 271065008678 D-loop; other site 271065008679 H-loop/switch region; other site 271065008680 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 271065008681 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 271065008682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271065008683 dimer interface [polypeptide binding]; other site 271065008684 conserved gate region; other site 271065008685 putative PBP binding loops; other site 271065008686 ABC-ATPase subunit interface; other site 271065008687 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 271065008688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271065008689 dimer interface [polypeptide binding]; other site 271065008690 conserved gate region; other site 271065008691 putative PBP binding loops; other site 271065008692 ABC-ATPase subunit interface; other site 271065008693 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 271065008694 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 271065008695 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 271065008696 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 271065008697 NAD binding site [chemical binding]; other site 271065008698 homotetramer interface [polypeptide binding]; other site 271065008699 homodimer interface [polypeptide binding]; other site 271065008700 substrate binding site [chemical binding]; other site 271065008701 active site 271065008702 periplasmic folding chaperone; Provisional; Region: PRK10788 271065008703 SurA N-terminal domain; Region: SurA_N_3; cl07813 271065008704 PPIC-type PPIASE domain; Region: Rotamase; cl08278 271065008705 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 271065008706 IHF dimer interface [polypeptide binding]; other site 271065008707 IHF - DNA interface [nucleotide binding]; other site 271065008708 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 271065008709 Found in ATP-dependent protease La (LON); Region: LON; smart00464 271065008710 Found in ATP-dependent protease La (LON); Region: LON; smart00464 271065008711 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065008712 Walker A motif; other site 271065008713 ATP binding site [chemical binding]; other site 271065008714 Walker B motif; other site 271065008715 arginine finger; other site 271065008716 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 271065008717 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 271065008718 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 271065008719 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065008720 Walker A motif; other site 271065008721 ATP binding site [chemical binding]; other site 271065008722 Walker B motif; other site 271065008723 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 271065008724 Clp protease; Region: CLP_protease; pfam00574 271065008725 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 271065008726 oligomer interface [polypeptide binding]; other site 271065008727 active site residues [active] 271065008728 trigger factor; Provisional; Region: tig; PRK01490 271065008729 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 271065008730 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 271065008731 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 271065008732 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 271065008733 GAF domain; Region: GAF; cl15785 271065008734 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065008735 Walker B motif; other site 271065008736 arginine finger; other site 271065008737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271065008738 putative substrate translocation pore; other site 271065008739 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 271065008740 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 271065008741 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 271065008742 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271065008743 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271065008744 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 271065008745 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 271065008746 GDP-binding site [chemical binding]; other site 271065008747 ACT binding site; other site 271065008748 IMP binding site; other site 271065008749 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 271065008750 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 271065008751 dimer interface [polypeptide binding]; other site 271065008752 motif 1; other site 271065008753 active site 271065008754 motif 2; other site 271065008755 motif 3; other site 271065008756 FtsH protease regulator HflC; Provisional; Region: PRK11029 271065008757 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 271065008758 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 271065008759 HflK protein; Region: hflK; TIGR01933 271065008760 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 271065008761 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 271065008762 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 271065008763 HflX GTPase family; Region: HflX; cd01878 271065008764 G1 box; other site 271065008765 GTP/Mg2+ binding site [chemical binding]; other site 271065008766 Switch I region; other site 271065008767 G2 box; other site 271065008768 G3 box; other site 271065008769 Switch II region; other site 271065008770 G4 box; other site 271065008771 G5 box; other site 271065008772 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 271065008773 Sm1 motif; other site 271065008774 D1 - D2 interaction site; other site 271065008775 D3 - B interaction site; other site 271065008776 Hfq - Hfq interaction site; other site 271065008777 RNA binding pocket [nucleotide binding]; other site 271065008778 Sm2 motif; other site 271065008779 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271065008780 acyl-CoA esterase; Provisional; Region: PRK10673 271065008781 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271065008782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 271065008783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065008784 HI0933-like protein; Region: HI0933_like; pfam03486 271065008785 Phosphate-starvation-inducible E; Region: PsiE; cl01264 271065008786 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 271065008787 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 271065008788 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 271065008789 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 271065008790 HemY protein N-terminus; Region: HemY_N; pfam07219 271065008791 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271065008792 binding surface 271065008793 TPR motif; other site 271065008794 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271065008795 binding surface 271065008796 TPR motif; other site 271065008797 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 271065008798 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 271065008799 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 271065008800 active site 271065008801 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 271065008802 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 271065008803 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 271065008804 domain interfaces; other site 271065008805 active site 271065008806 argininosuccinate lyase; Provisional; Region: PRK00855 271065008807 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 271065008808 active sites [active] 271065008809 tetramer interface [polypeptide binding]; other site 271065008810 adenylate cyclase; Provisional; Region: cyaA; PRK09450 271065008811 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 271065008812 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 271065008813 PilZ domain; Region: PilZ; cl01260 271065008814 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 271065008815 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 271065008816 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065008817 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 271065008818 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 271065008819 pyruvate kinase; Provisional; Region: PRK05826 271065008820 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 271065008821 domain interfaces; other site 271065008822 active site 271065008823 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 271065008824 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065008825 PAS domain; Region: PAS_9; pfam13426 271065008826 putative active site [active] 271065008827 heme pocket [chemical binding]; other site 271065008828 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 271065008829 hydrophobic ligand binding site; other site 271065008830 PAS domain; Region: PAS_9; pfam13426 271065008831 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065008832 putative active site [active] 271065008833 heme pocket [chemical binding]; other site 271065008834 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 271065008835 hydrophobic ligand binding site; other site 271065008836 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 271065008837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 271065008838 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 271065008839 anchoring element; other site 271065008840 dimer interface [polypeptide binding]; other site 271065008841 ATP binding site [chemical binding]; other site 271065008842 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 271065008843 active site 271065008844 metal binding site [ion binding]; metal-binding site 271065008845 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 271065008846 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 271065008847 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 271065008848 substrate binding pocket [chemical binding]; other site 271065008849 chain length determination region; other site 271065008850 substrate-Mg2+ binding site; other site 271065008851 catalytic residues [active] 271065008852 aspartate-rich region 1; other site 271065008853 active site lid residues [active] 271065008854 aspartate-rich region 2; other site 271065008855 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 271065008856 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 271065008857 TPP-binding site; other site 271065008858 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 271065008859 PYR/PP interface [polypeptide binding]; other site 271065008860 dimer interface [polypeptide binding]; other site 271065008861 TPP binding site [chemical binding]; other site 271065008862 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 271065008863 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 271065008864 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 271065008865 active site 271065008866 VacJ like lipoprotein; Region: VacJ; cl01073 271065008867 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 271065008868 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 271065008869 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271065008870 FeS/SAM binding site; other site 271065008871 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 271065008872 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 271065008873 active site lid residues [active] 271065008874 substrate binding pocket [chemical binding]; other site 271065008875 catalytic residues [active] 271065008876 substrate-Mg2+ binding site; other site 271065008877 aspartate-rich region 1; other site 271065008878 aspartate-rich region 2; other site 271065008879 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 271065008880 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 271065008881 Active site cavity [active] 271065008882 catalytic acid [active] 271065008883 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 271065008884 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 271065008885 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 271065008886 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 271065008887 inhibitor-cofactor binding pocket; inhibition site 271065008888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271065008889 catalytic residue [active] 271065008890 PemK-like protein; Region: PemK; cl00995 271065008891 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065008892 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 271065008893 apolar tunnel; other site 271065008894 heme binding site [chemical binding]; other site 271065008895 dimerization interface [polypeptide binding]; other site 271065008896 YccA-like proteins; Region: YccA_like; cd10433 271065008897 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 271065008898 putative active site [active] 271065008899 catalytic residue [active] 271065008900 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 271065008901 Domain of unknown function DUF21; Region: DUF21; pfam01595 271065008902 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 271065008903 Transporter associated domain; Region: CorC_HlyC; cl08393 271065008904 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 271065008905 PilZ domain; Region: PilZ; cl01260 271065008906 DNA repair protein RadA; Provisional; Region: PRK11823 271065008907 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065008908 Walker A motif; other site 271065008909 ATP binding site [chemical binding]; other site 271065008910 Walker B motif; other site 271065008911 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 271065008912 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 271065008913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065008914 active site 271065008915 phosphorylation site [posttranslational modification] 271065008916 intermolecular recognition site; other site 271065008917 dimerization interface [polypeptide binding]; other site 271065008918 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271065008919 DNA binding site [nucleotide binding] 271065008920 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 271065008921 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 271065008922 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 271065008923 tandem repeat interface [polypeptide binding]; other site 271065008924 oligomer interface [polypeptide binding]; other site 271065008925 active site residues [active] 271065008926 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 271065008927 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271065008928 motif II; other site 271065008929 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 271065008930 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 271065008931 RNA binding surface [nucleotide binding]; other site 271065008932 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 271065008933 active site 271065008934 ribonuclease E; Reviewed; Region: rne; PRK10811 271065008935 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 271065008936 homodimer interface [polypeptide binding]; other site 271065008937 oligonucleotide binding site [chemical binding]; other site 271065008938 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 271065008939 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 271065008940 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 271065008941 generic binding surface II; other site 271065008942 generic binding surface I; other site 271065008943 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 271065008944 RNA/DNA hybrid binding site [nucleotide binding]; other site 271065008945 active site 271065008946 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 271065008947 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 271065008948 active site 271065008949 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 271065008950 periplasmic chaperone; Provisional; Region: PRK10780 271065008951 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 271065008952 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 271065008953 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 271065008954 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 271065008955 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 271065008956 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 271065008957 Surface antigen; Region: Bac_surface_Ag; cl03097 271065008958 Predicted ATPase [General function prediction only]; Region: COG1485 271065008959 hypothetical protein; Provisional; Region: PRK11295 271065008960 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 271065008961 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199 271065008962 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 271065008963 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 271065008964 active site 271065008965 thymidine phosphorylase; Provisional; Region: PRK04350 271065008966 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 271065008967 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 271065008968 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 271065008969 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 271065008970 Response regulator receiver domain; Region: Response_reg; pfam00072 271065008971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065008972 active site 271065008973 phosphorylation site [posttranslational modification] 271065008974 intermolecular recognition site; other site 271065008975 dimerization interface [polypeptide binding]; other site 271065008976 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271065008977 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 271065008978 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065008979 CheD chemotactic sensory transduction; Region: CheD; cl00810 271065008980 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 271065008981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065008982 active site 271065008983 phosphorylation site [posttranslational modification] 271065008984 intermolecular recognition site; other site 271065008985 dimerization interface [polypeptide binding]; other site 271065008986 CheB methylesterase; Region: CheB_methylest; pfam01339 271065008987 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065008988 Methyltransferase domain; Region: Methyltransf_31; pfam13847 271065008989 S-adenosylmethionine binding site [chemical binding]; other site 271065008990 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 271065008991 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 271065008992 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 271065008993 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 271065008994 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 271065008995 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 271065008996 UbiA prenyltransferase family; Region: UbiA; cl00337 271065008997 hypothetical protein; Validated; Region: PRK09071 271065008998 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 271065008999 PilZ domain; Region: PilZ; cl01260 271065009000 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 271065009001 N-acetyl-D-glucosamine binding site [chemical binding]; other site 271065009002 catalytic residue [active] 271065009003 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 271065009004 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 271065009005 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 271065009006 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 271065009007 putative CheA interaction surface; other site 271065009008 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 271065009009 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 271065009010 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 271065009011 Magnesium ion binding site [ion binding]; other site 271065009012 flagellar motor protein MotB; Reviewed; Region: motB; PRK08944 271065009013 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 271065009014 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271065009015 ligand binding site [chemical binding]; other site 271065009016 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 271065009017 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 271065009018 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 271065009019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065009020 active site 271065009021 phosphorylation site [posttranslational modification] 271065009022 intermolecular recognition site; other site 271065009023 CheB methylesterase; Region: CheB_methylest; pfam01339 271065009024 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 271065009025 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 271065009026 putative binding surface; other site 271065009027 active site 271065009028 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 271065009029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065009030 ATP binding site [chemical binding]; other site 271065009031 Mg2+ binding site [ion binding]; other site 271065009032 G-X-G motif; other site 271065009033 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 271065009034 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 271065009035 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 271065009036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065009037 active site 271065009038 phosphorylation site [posttranslational modification] 271065009039 intermolecular recognition site; other site 271065009040 dimerization interface [polypeptide binding]; other site 271065009041 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 271065009042 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271065009043 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 271065009044 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 271065009045 DNA binding residues [nucleotide binding] 271065009046 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 271065009047 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 271065009048 P-loop; other site 271065009049 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 271065009050 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 271065009051 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065009052 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 271065009053 FHIPEP family; Region: FHIPEP; pfam00771 271065009054 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 271065009055 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 271065009056 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 271065009057 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 271065009058 FliP family; Region: FliP; cl00593 271065009059 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 271065009060 flagellar motor switch protein; Validated; Region: fliN; PRK05698 271065009061 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 271065009062 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 271065009063 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 271065009064 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 271065009065 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065009066 metal binding site [ion binding]; metal-binding site 271065009067 active site 271065009068 I-site; other site 271065009069 Predicted membrane protein [Function unknown]; Region: COG4655 271065009070 TadE-like protein; Region: TadE; cl10688 271065009071 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 271065009072 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 271065009073 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271065009074 binding surface 271065009075 TPR motif; other site 271065009076 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 271065009077 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 271065009078 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 271065009079 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 271065009080 ATP binding site [chemical binding]; other site 271065009081 Walker A motif; other site 271065009082 hexamer interface [polypeptide binding]; other site 271065009083 Walker B motif; other site 271065009084 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 271065009085 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065009086 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 271065009087 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 271065009088 SAF domain; Region: SAF; cl00555 271065009089 TadE-like protein; Region: TadE; cl10688 271065009090 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 271065009091 Flp/Fap pilin component; Region: Flp_Fap; cl01585 271065009092 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 271065009093 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 271065009094 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 271065009095 DNA-binding site [nucleotide binding]; DNA binding site 271065009096 RNA-binding motif; other site 271065009097 Protein of unknown function (DUF770); Region: DUF770; cl01402 271065009098 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 271065009099 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271065009100 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 271065009101 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 271065009102 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 271065009103 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 271065009104 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 271065009105 active site 271065009106 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 271065009107 ScpA/B protein; Region: ScpA_ScpB; cl00598 271065009108 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 271065009109 active site 271065009110 putative substrate binding region [chemical binding]; other site 271065009111 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 271065009112 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 271065009113 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 271065009114 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065009115 DEAD_2; Region: DEAD_2; pfam06733 271065009116 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065009117 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 271065009118 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 271065009119 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 271065009120 trimer interface [polypeptide binding]; other site 271065009121 active site 271065009122 UDP-GlcNAc binding site [chemical binding]; other site 271065009123 lipid binding site [chemical binding]; lipid-binding site 271065009124 elongation factor G; Reviewed; Region: PRK00007 271065009125 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 271065009126 G1 box; other site 271065009127 putative GEF interaction site [polypeptide binding]; other site 271065009128 GTP/Mg2+ binding site [chemical binding]; other site 271065009129 Switch I region; other site 271065009130 G2 box; other site 271065009131 G3 box; other site 271065009132 Switch II region; other site 271065009133 G4 box; other site 271065009134 G5 box; other site 271065009135 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 271065009136 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 271065009137 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 271065009138 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 271065009139 conserved hypothetical protein; Region: QEGLA; TIGR02421 271065009140 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 271065009141 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 271065009142 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 271065009143 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 271065009144 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 271065009145 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 271065009146 catalytic triad [active] 271065009147 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 271065009148 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 271065009149 putative active site [active] 271065009150 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065009151 Domain of unknown function DUF20; Region: UPF0118; pfam01594 271065009152 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 271065009153 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 271065009154 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 271065009155 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 271065009156 active site 271065009157 catalytic site [active] 271065009158 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 271065009159 Peptidase family M48; Region: Peptidase_M48; cl12018 271065009160 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 271065009161 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 271065009162 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 271065009163 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 271065009164 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065009165 CoA-ligase; Region: Ligase_CoA; cl02894 271065009166 malate--CoA ligase subunit beta; Provisional; Region: PRK14046 271065009167 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271065009168 CoA-ligase; Region: Ligase_CoA; cl02894 271065009169 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 271065009170 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 271065009171 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 271065009172 homodimer interface [polypeptide binding]; other site 271065009173 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271065009174 catalytic residue [active] 271065009175 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 271065009176 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065009177 malate dehydrogenase; Provisional; Region: PRK05442 271065009178 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 271065009179 NAD(P) binding site [chemical binding]; other site 271065009180 dimer interface [polypeptide binding]; other site 271065009181 malate binding site [chemical binding]; other site 271065009182 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 271065009183 NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078 271065009184 NADP binding site [chemical binding]; other site 271065009185 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 271065009186 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 271065009187 MOFRL family; Region: MOFRL; pfam05161 271065009188 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 271065009189 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 271065009190 dimer interface [polypeptide binding]; other site 271065009191 active site 271065009192 glycine-pyridoxal phosphate binding site [chemical binding]; other site 271065009193 folate binding site [chemical binding]; other site 271065009194 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 271065009195 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 271065009196 Potassium binding sites [ion binding]; other site 271065009197 Cesium cation binding sites [ion binding]; other site 271065009198 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 271065009199 putative active site [active] 271065009200 phosphomannomutase CpsG; Provisional; Region: PRK15414 271065009201 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 271065009202 active site 271065009203 substrate binding site [chemical binding]; other site 271065009204 metal binding site [ion binding]; metal-binding site 271065009205 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 271065009206 dimer interface [polypeptide binding]; other site 271065009207 catalytic triad [active] 271065009208 peroxidatic and resolving cysteines [active] 271065009209 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 271065009210 methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463 271065009211 substrate binding site [chemical binding]; other site 271065009212 active site 271065009213 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 271065009214 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065009215 Sporulation related domain; Region: SPOR; cl10051 271065009216 Evidence 2b : Function of strongly homologous gene; PubMedId : 15103156, 7901733; Product type e : enzyme 271065009217 Evidence 2b : Function of strongly homologous gene; PubMedId : 15103156, 7901733; Product type e : enzyme 271065009218 AMIN domain; Region: AMIN; pfam11741 271065009219 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 271065009220 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 271065009221 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 271065009222 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 271065009223 Pilus assembly protein, PilP; Region: PilP; cl01235 271065009224 Pilus assembly protein, PilO; Region: PilO; cl01234 271065009225 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 271065009226 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 271065009227 Cell division protein FtsA; Region: FtsA; cl11496 271065009228 Competence protein A; Region: Competence_A; pfam11104 271065009229 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 271065009230 Transglycosylase; Region: Transgly; cl07896 271065009231 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 271065009232 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 271065009233 Sodium:solute symporter family; Region: SSF; cl00456 271065009234 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271065009235 TPR motif; other site 271065009236 TPR repeat; Region: TPR_11; pfam13414 271065009237 binding surface 271065009238 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 271065009239 aspartate kinase; Validated; Region: PRK09181 271065009240 AAK_AK-Ectoine: Amino Acid Kinase Superfamily (AAK), AK-Ectoine; this CD includes the N-terminal catalytic domain of the aspartokinase of the ectoine (1,4,5,6-tetrahydro-2-methyl pyrimidine-4-carboxylate) biosynthetic pathway found in Methylomicrobium...; Region: AAK_AK-Ectoine; cd04248 271065009241 putative catalytic residues [active] 271065009242 putative nucleotide binding site [chemical binding]; other site 271065009243 putative aspartate binding site [chemical binding]; other site 271065009244 ACT domains located C-terminal to the catalytic domain of the aspartokinase of the ectoine (1,4,5,6-tetrahydro-2-methyl pyrimidine-4-carboxylate) biosynthetic pathway; Region: ACT_AK-Ectoine_1; cd04910 271065009245 allosteric regulatory residue; other site 271065009246 ACT domains located C-terminal to the catalytic domain of the aspartokinase of the ectoine (1,4,5,6-tetrahydro-2-methyl pyrimidine-4-carboxylate) biosynthetic pathway; Region: ACT_AK-Ectoine_2; cd04915 271065009247 Cupin domain; Region: Cupin_2; cl09118 271065009248 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 271065009249 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 271065009250 inhibitor-cofactor binding pocket; inhibition site 271065009251 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271065009252 catalytic residue [active] 271065009253 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271065009254 Coenzyme A binding pocket [chemical binding]; other site 271065009255 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 271065009256 Helix-turn-helix domains; Region: HTH; cl00088 271065009257 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 271065009258 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 271065009259 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 271065009260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065009261 S-adenosylmethionine binding site [chemical binding]; other site 271065009262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065009263 Sulfate transporter family; Region: Sulfate_transp; cl15842 271065009264 Sulfate transporter family; Region: Sulfate_transp; cl15842 271065009265 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 271065009266 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 271065009267 Helix-turn-helix domains; Region: HTH; cl00088 271065009268 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271065009269 dimerization interface [polypeptide binding]; other site 271065009270 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065009271 S-adenosylmethionine binding site [chemical binding]; other site 271065009272 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 271065009273 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 271065009274 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 271065009275 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 271065009276 putative active site [active] 271065009277 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 271065009278 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 271065009279 oligomeric interface; other site 271065009280 putative active site [active] 271065009281 homodimer interface [polypeptide binding]; other site 271065009282 ABC-2 type transporter; Region: ABC2_membrane; cl11417 271065009283 Methyltransferase domain; Region: Methyltransf_31; pfam13847 271065009284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065009285 S-adenosylmethionine binding site [chemical binding]; other site 271065009286 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 271065009287 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 271065009288 putative active site [active] 271065009289 Protein of unknown function (DUF497); Region: DUF497; cl01108 271065009290 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 271065009291 Predicted transcriptional regulator [Transcription]; Region: COG2944 271065009292 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 271065009293 putative major pilin subunit; Provisional; Region: PRK10574 271065009294 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 271065009295 Transposase [DNA replication, recombination, and repair]; Region: COG5433 271065009296 Transposase [DNA replication, recombination, and repair]; Region: COG5433 271065009297 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 271065009298 Helix-turn-helix domains; Region: HTH; cl00088 271065009299 rod shape-determining protein MreC; Provisional; Region: PRK13922 271065009300 Winged helix-turn helix; Region: HTH_29; pfam13551 271065009301 Helix-turn-helix domains; Region: HTH; cl00088 271065009302 Integrase core domain; Region: rve; cl01316 271065009303 Integrase core domain; Region: rve_3; cl15866 271065009304 Domain of unknown function (DUF1902); Region: DUF1902; pfam08972 271065009305 muropeptide transporter; Validated; Region: ampG; PRK11010 271065009306 AmpG-related permease; Region: 2A0125; TIGR00901 271065009307 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 271065009308 transmembrane helices; other site 271065009309 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 271065009310 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 271065009311 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 271065009312 Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526 271065009313 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 271065009314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065009315 CoA-ligase; Region: Ligase_CoA; cl02894 271065009316 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 271065009317 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271065009318 CoA-ligase; Region: Ligase_CoA; cl02894 271065009319 sensory histidine kinase AtoS; Provisional; Region: PRK11360 271065009320 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065009321 dimer interface [polypeptide binding]; other site 271065009322 phosphorylation site [posttranslational modification] 271065009323 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065009324 ATP binding site [chemical binding]; other site 271065009325 Mg2+ binding site [ion binding]; other site 271065009326 G-X-G motif; other site 271065009327 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 271065009328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065009329 active site 271065009330 phosphorylation site [posttranslational modification] 271065009331 intermolecular recognition site; other site 271065009332 dimerization interface [polypeptide binding]; other site 271065009333 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065009334 Walker A motif; other site 271065009335 ATP binding site [chemical binding]; other site 271065009336 Walker B motif; other site 271065009337 arginine finger; other site 271065009338 Helix-turn-helix domains; Region: HTH; cl00088 271065009339 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 271065009340 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065009341 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 271065009342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065009343 proline aminopeptidase P II; Provisional; Region: PRK10879 271065009344 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 271065009345 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 271065009346 active site 271065009347 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 271065009348 Cell division protein ZapA; Region: ZapA; cl01146 271065009349 EVE domain; Region: EVE; cl00728 271065009350 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 271065009351 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 271065009352 active site 271065009353 ADP/pyrophosphate binding site [chemical binding]; other site 271065009354 dimerization interface [polypeptide binding]; other site 271065009355 allosteric effector site; other site 271065009356 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 271065009357 fructose-1,6-bisphosphate binding site; other site 271065009358 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 271065009359 hypothetical protein; Provisional; Region: PRK01254 271065009360 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 271065009361 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 271065009362 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 271065009363 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 271065009364 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 271065009365 Porin subfamily; Region: Porin_2; pfam02530 271065009366 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 271065009367 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271065009368 Coenzyme A binding pocket [chemical binding]; other site 271065009369 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 271065009370 Fe-S cluster binding site [ion binding]; other site 271065009371 active site 271065009372 2-isopropylmalate synthase; Validated; Region: PRK00915 271065009373 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 271065009374 active site 271065009375 catalytic residues [active] 271065009376 metal binding site [ion binding]; metal-binding site 271065009377 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 271065009378 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 271065009379 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 271065009380 ketol-acid reductoisomerase; Provisional; Region: PRK05479 271065009381 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065009382 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 271065009383 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 271065009384 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 271065009385 putative valine binding site [chemical binding]; other site 271065009386 dimer interface [polypeptide binding]; other site 271065009387 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 271065009388 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 271065009389 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 271065009390 PYR/PP interface [polypeptide binding]; other site 271065009391 dimer interface [polypeptide binding]; other site 271065009392 TPP binding site [chemical binding]; other site 271065009393 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 271065009394 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 271065009395 TPP-binding site [chemical binding]; other site 271065009396 dimer interface [polypeptide binding]; other site 271065009397 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 271065009398 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 271065009399 tetramer interface [polypeptide binding]; other site 271065009400 active site 271065009401 Mg2+/Mn2+ binding site [ion binding]; other site 271065009402 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 271065009403 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 271065009404 MoaE homodimer interface [polypeptide binding]; other site 271065009405 MoaD interaction [polypeptide binding]; other site 271065009406 active site residues [active] 271065009407 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 271065009408 MoaE interaction surface [polypeptide binding]; other site 271065009409 MoeB interaction surface [polypeptide binding]; other site 271065009410 thiocarboxylated glycine; other site 271065009411 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 271065009412 trimer interface [polypeptide binding]; other site 271065009413 dimer interface [polypeptide binding]; other site 271065009414 putative active site [active] 271065009415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271065009416 dimer interface [polypeptide binding]; other site 271065009417 conserved gate region; other site 271065009418 putative PBP binding loops; other site 271065009419 ABC-ATPase subunit interface; other site 271065009420 superoxide dismutase; Provisional; Region: PRK10543 271065009421 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 271065009422 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 271065009423 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 271065009424 putative active site [active] 271065009425 putative metal binding residues [ion binding]; other site 271065009426 signature motif; other site 271065009427 putative dimer interface [polypeptide binding]; other site 271065009428 putative phosphate binding site [ion binding]; other site 271065009429 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 271065009430 TPR motif; other site 271065009431 binding surface 271065009432 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 271065009433 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 271065009434 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 271065009435 alphaNTD homodimer interface [polypeptide binding]; other site 271065009436 alphaNTD - beta interaction site [polypeptide binding]; other site 271065009437 alphaNTD - beta' interaction site [polypeptide binding]; other site 271065009438 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 271065009439 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 271065009440 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 271065009441 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 271065009442 RNA binding surface [nucleotide binding]; other site 271065009443 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 271065009444 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 271065009445 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 271065009446 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 271065009447 SecY translocase; Region: SecY; pfam00344 271065009448 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 271065009449 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 271065009450 23S rRNA binding site [nucleotide binding]; other site 271065009451 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 271065009452 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 271065009453 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 271065009454 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 271065009455 5S rRNA interface [nucleotide binding]; other site 271065009456 23S rRNA interface [nucleotide binding]; other site 271065009457 L5 interface [polypeptide binding]; other site 271065009458 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 271065009459 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 271065009460 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 271065009461 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 271065009462 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 271065009463 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 271065009464 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 271065009465 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 271065009466 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 271065009467 KOW motif; Region: KOW; cl00354 271065009468 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 271065009469 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 271065009470 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 271065009471 23S rRNA interface [nucleotide binding]; other site 271065009472 putative translocon interaction site; other site 271065009473 signal recognition particle (SRP54) interaction site; other site 271065009474 L23 interface [polypeptide binding]; other site 271065009475 trigger factor interaction site; other site 271065009476 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 271065009477 23S rRNA interface [nucleotide binding]; other site 271065009478 5S rRNA interface [nucleotide binding]; other site 271065009479 putative antibiotic binding site [chemical binding]; other site 271065009480 L25 interface [polypeptide binding]; other site 271065009481 L27 interface [polypeptide binding]; other site 271065009482 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 271065009483 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 271065009484 G-X-X-G motif; other site 271065009485 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 271065009486 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 271065009487 putative translocon binding site; other site 271065009488 protein-rRNA interface [nucleotide binding]; other site 271065009489 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 271065009490 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 271065009491 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 271065009492 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 271065009493 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 271065009494 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 271065009495 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 271065009496 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 271065009497 elongation factor Tu; Reviewed; Region: PRK00049 271065009498 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 271065009499 G1 box; other site 271065009500 GEF interaction site [polypeptide binding]; other site 271065009501 GTP/Mg2+ binding site [chemical binding]; other site 271065009502 Switch I region; other site 271065009503 G2 box; other site 271065009504 G3 box; other site 271065009505 Switch II region; other site 271065009506 G4 box; other site 271065009507 G5 box; other site 271065009508 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 271065009509 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 271065009510 Antibiotic Binding Site [chemical binding]; other site 271065009511 elongation factor G; Reviewed; Region: PRK00007 271065009512 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 271065009513 G1 box; other site 271065009514 putative GEF interaction site [polypeptide binding]; other site 271065009515 GTP/Mg2+ binding site [chemical binding]; other site 271065009516 Switch I region; other site 271065009517 G2 box; other site 271065009518 G3 box; other site 271065009519 Switch II region; other site 271065009520 G4 box; other site 271065009521 G5 box; other site 271065009522 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 271065009523 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 271065009524 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 271065009525 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 271065009526 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 271065009527 S17 interaction site [polypeptide binding]; other site 271065009528 S8 interaction site; other site 271065009529 16S rRNA interaction site [nucleotide binding]; other site 271065009530 streptomycin interaction site [chemical binding]; other site 271065009531 23S rRNA interaction site [nucleotide binding]; other site 271065009532 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 271065009533 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 271065009534 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 271065009535 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 271065009536 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 271065009537 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 271065009538 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 271065009539 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 271065009540 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 271065009541 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 271065009542 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 271065009543 DNA binding site [nucleotide binding] 271065009544 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 271065009545 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 271065009546 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 271065009547 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 271065009548 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 271065009549 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 271065009550 RPB11 interaction site [polypeptide binding]; other site 271065009551 RPB12 interaction site [polypeptide binding]; other site 271065009552 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 271065009553 RPB3 interaction site [polypeptide binding]; other site 271065009554 RPB1 interaction site [polypeptide binding]; other site 271065009555 RPB11 interaction site [polypeptide binding]; other site 271065009556 RPB10 interaction site [polypeptide binding]; other site 271065009557 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 271065009558 peripheral dimer interface [polypeptide binding]; other site 271065009559 core dimer interface [polypeptide binding]; other site 271065009560 L10 interface [polypeptide binding]; other site 271065009561 L11 interface [polypeptide binding]; other site 271065009562 putative EF-Tu interaction site [polypeptide binding]; other site 271065009563 putative EF-G interaction site [polypeptide binding]; other site 271065009564 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 271065009565 23S rRNA interface [nucleotide binding]; other site 271065009566 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 271065009567 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 271065009568 mRNA/rRNA interface [nucleotide binding]; other site 271065009569 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 271065009570 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 271065009571 23S rRNA interface [nucleotide binding]; other site 271065009572 L7/L12 interface [polypeptide binding]; other site 271065009573 putative thiostrepton binding site; other site 271065009574 L25 interface [polypeptide binding]; other site 271065009575 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 271065009576 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 271065009577 putative homodimer interface [polypeptide binding]; other site 271065009578 KOW motif; Region: KOW; cl00354 271065009579 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 271065009580 elongation factor Tu; Reviewed; Region: PRK00049 271065009581 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 271065009582 G1 box; other site 271065009583 GEF interaction site [polypeptide binding]; other site 271065009584 GTP/Mg2+ binding site [chemical binding]; other site 271065009585 Switch I region; other site 271065009586 G2 box; other site 271065009587 G3 box; other site 271065009588 Switch II region; other site 271065009589 G4 box; other site 271065009590 G5 box; other site 271065009591 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 271065009592 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 271065009593 Antibiotic Binding Site [chemical binding]; other site 271065009594 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 271065009595 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 271065009596 5S rRNA interface [nucleotide binding]; other site 271065009597 CTC domain interface [polypeptide binding]; other site 271065009598 L16 interface [polypeptide binding]; other site 271065009599 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 271065009600 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 271065009601 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 271065009602 active site 271065009603 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 271065009604 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 271065009605 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 271065009606 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 271065009607 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 271065009608 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 271065009609 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271065009610 binding surface 271065009611 TPR motif; other site 271065009612 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271065009613 binding surface 271065009614 TPR motif; other site 271065009615 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 271065009616 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 271065009617 tRNA; other site 271065009618 putative tRNA binding site [nucleotide binding]; other site 271065009619 putative NADP binding site [chemical binding]; other site 271065009620 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 271065009621 peptide chain release factor 1; Validated; Region: prfA; PRK00591 271065009622 RF-1 domain; Region: RF-1; cl02875 271065009623 RF-1 domain; Region: RF-1; cl02875 271065009624 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 271065009625 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 271065009626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065009627 S-adenosylmethionine binding site [chemical binding]; other site 271065009628 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 271065009629 MPN+ (JAMM) motif; other site 271065009630 Zinc-binding site [ion binding]; other site 271065009631 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 271065009632 putative active site [active] 271065009633 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 271065009634 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 271065009635 GatB domain; Region: GatB_Yqey; cl11497 271065009636 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 271065009637 putative active site [active] 271065009638 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 271065009639 Amidase; Region: Amidase; cl11426 271065009640 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 271065009641 rod shape-determining protein MreB; Provisional; Region: PRK13927 271065009642 Cell division protein FtsA; Region: FtsA; cl11496 271065009643 rod shape-determining protein MreC; Provisional; Region: PRK13922 271065009644 rod shape-determining protein MreC; Region: MreC; pfam04085 271065009645 rod shape-determining protein MreD; Region: MreD; cl01087 271065009646 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 271065009647 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 271065009648 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 271065009649 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 271065009650 Transglycosylase SLT domain; Region: SLT_2; pfam13406 271065009651 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 271065009652 N-acetyl-D-glucosamine binding site [chemical binding]; other site 271065009653 Sporulation related domain; Region: SPOR; cl10051 271065009654 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 271065009655 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 271065009656 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 271065009657 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 271065009658 homodimer interface [polypeptide binding]; other site 271065009659 substrate-cofactor binding pocket; other site 271065009660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271065009661 catalytic residue [active] 271065009662 Protein of unknown function (DUF493); Region: DUF493; cl01102 271065009663 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 271065009664 lipoyl synthase; Provisional; Region: PRK05481 271065009665 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271065009666 FeS/SAM binding site; other site 271065009667 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 271065009668 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 271065009669 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 271065009670 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 271065009671 RNA binding site [nucleotide binding]; other site 271065009672 putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073 271065009673 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 271065009674 active site 271065009675 metal binding site [ion binding]; metal-binding site 271065009676 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 271065009677 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 271065009678 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 271065009679 putative active site [active] 271065009680 catalytic triad [active] 271065009681 putative dimer interface [polypeptide binding]; other site 271065009682 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 271065009683 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 271065009684 Zn2+ binding site [ion binding]; other site 271065009685 Mg2+ binding site [ion binding]; other site 271065009686 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 271065009687 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 271065009688 P-loop; other site 271065009689 Magnesium ion binding site [ion binding]; other site 271065009690 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 271065009691 Magnesium ion binding site [ion binding]; other site 271065009692 Protein of unknown function (DUF1451); Region: DUF1451; pfam07295 271065009693 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 271065009694 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 271065009695 HIGH motif; other site 271065009696 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 271065009697 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 271065009698 active site 271065009699 KMSKS motif; other site 271065009700 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 271065009701 tRNA binding surface [nucleotide binding]; other site 271065009702 Lipopolysaccharide-assembly; Region: LptE; cl01125 271065009703 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 271065009704 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 271065009705 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 271065009706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065009707 ATP binding site [chemical binding]; other site 271065009708 Mg2+ binding site [ion binding]; other site 271065009709 G-X-G motif; other site 271065009710 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 271065009711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065009712 active site 271065009713 phosphorylation site [posttranslational modification] 271065009714 intermolecular recognition site; other site 271065009715 dimerization interface [polypeptide binding]; other site 271065009716 Tetratricopeptide repeat; Region: TPR_16; pfam13432 271065009717 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271065009718 binding surface 271065009719 Tetratricopeptide repeat; Region: TPR_16; pfam13432 271065009720 TPR motif; other site 271065009721 heat shock protein 90; Provisional; Region: PRK05218 271065009722 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065009723 ATP binding site [chemical binding]; other site 271065009724 Mg2+ binding site [ion binding]; other site 271065009725 G-X-G motif; other site 271065009726 Post-segregation antitoxin CcdA; Region: CcdA; cl02188 271065009727 spermidine synthase; Provisional; Region: PRK00811 271065009728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 271065009729 arginine decarboxylase; Provisional; Region: PRK05354 271065009730 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 271065009731 dimer interface [polypeptide binding]; other site 271065009732 active site 271065009733 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 271065009734 catalytic residues [active] 271065009735 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 271065009736 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 271065009737 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065009738 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065009739 Walker A/P-loop; other site 271065009740 ATP binding site [chemical binding]; other site 271065009741 Q-loop/lid; other site 271065009742 homoserine O-succinyltransferase; Provisional; Region: PRK05368 271065009743 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 271065009744 proposed active site lysine [active] 271065009745 conserved cys residue [active] 271065009746 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 271065009747 nucleoside/Zn binding site; other site 271065009748 dimer interface [polypeptide binding]; other site 271065009749 catalytic motif [active] 271065009750 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 271065009751 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 271065009752 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 271065009753 dimerization interface [polypeptide binding]; other site 271065009754 putative ATP binding site [chemical binding]; other site 271065009755 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 271065009756 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 271065009757 active site 271065009758 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 271065009759 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 271065009760 PhnA protein; Region: PhnA; pfam03831 271065009761 DNA topoisomerase I; Validated; Region: PRK06599 271065009762 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 271065009763 active site 271065009764 interdomain interaction site; other site 271065009765 putative metal-binding site [ion binding]; other site 271065009766 nucleotide binding site [chemical binding]; other site 271065009767 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 271065009768 domain I; other site 271065009769 DNA binding groove [nucleotide binding] 271065009770 phosphate binding site [ion binding]; other site 271065009771 domain II; other site 271065009772 domain III; other site 271065009773 nucleotide binding site [chemical binding]; other site 271065009774 catalytic site [active] 271065009775 domain IV; other site 271065009776 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 271065009777 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 271065009778 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 271065009779 Protein of unknown function (DUF494); Region: DUF494; cl01103 271065009780 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 271065009781 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 271065009782 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 271065009783 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 271065009784 active site 271065009785 catalytic residues [active] 271065009786 metal binding site [ion binding]; metal-binding site 271065009787 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 271065009788 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 271065009789 putative active site [active] 271065009790 substrate binding site [chemical binding]; other site 271065009791 putative cosubstrate binding site; other site 271065009792 catalytic site [active] 271065009793 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 271065009794 substrate binding site [chemical binding]; other site 271065009795 16S rRNA methyltransferase B; Provisional; Region: PRK10901 271065009796 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 271065009797 putative RNA binding site [nucleotide binding]; other site 271065009798 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065009799 S-adenosylmethionine binding site [chemical binding]; other site 271065009800 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 271065009801 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 271065009802 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 271065009803 dimerization interface [polypeptide binding]; other site 271065009804 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271065009805 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065009806 dimer interface [polypeptide binding]; other site 271065009807 phosphorylation site [posttranslational modification] 271065009808 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065009809 ATP binding site [chemical binding]; other site 271065009810 Mg2+ binding site [ion binding]; other site 271065009811 G-X-G motif; other site 271065009812 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 271065009813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065009814 active site 271065009815 phosphorylation site [posttranslational modification] 271065009816 intermolecular recognition site; other site 271065009817 dimerization interface [polypeptide binding]; other site 271065009818 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065009819 Walker A motif; other site 271065009820 ATP binding site [chemical binding]; other site 271065009821 Walker B motif; other site 271065009822 arginine finger; other site 271065009823 Helix-turn-helix domains; Region: HTH; cl00088 271065009824 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 271065009825 23S rRNA interface [nucleotide binding]; other site 271065009826 L3 interface [polypeptide binding]; other site 271065009827 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 271065009828 threonine dehydratase; Reviewed; Region: PRK09224 271065009829 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 271065009830 tetramer interface [polypeptide binding]; other site 271065009831 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271065009832 catalytic residue [active] 271065009833 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 271065009834 putative Ile/Val binding site [chemical binding]; other site 271065009835 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 271065009836 putative Ile/Val binding site [chemical binding]; other site 271065009837 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 271065009838 tetramer (dimer of dimers) interface [polypeptide binding]; other site 271065009839 active site 271065009840 dimer interface [polypeptide binding]; other site 271065009841 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 271065009842 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 271065009843 metal ion-dependent adhesion site (MIDAS); other site 271065009844 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 271065009845 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 271065009846 MoxR-like ATPases [General function prediction only]; Region: COG0714 271065009847 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065009848 Walker A motif; other site 271065009849 ATP binding site [chemical binding]; other site 271065009850 Walker B motif; other site 271065009851 arginine finger; other site 271065009852 Methanol dehydrogenase beta subunit; Region: MDH; pfam02315 271065009853 Cytochrome c; Region: Cytochrom_C; cl11414 271065009854 methanol oxidation system protein MoxJ; Region: ABC_MoxJ; TIGR03870 271065009855 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271065009856 membrane-bound complex binding site; other site 271065009857 hinge residues; other site 271065009858 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 271065009859 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 271065009860 Trp docking motif [polypeptide binding]; other site 271065009861 dimer interface [polypeptide binding]; other site 271065009862 active site 271065009863 small subunit binding site [polypeptide binding]; other site 271065009864 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 271065009865 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065009866 active site 271065009867 phosphorylation site [posttranslational modification] 271065009868 intermolecular recognition site; other site 271065009869 dimerization interface [polypeptide binding]; other site 271065009870 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271065009871 DNA binding residues [nucleotide binding] 271065009872 dimerization interface [polypeptide binding]; other site 271065009873 Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA; cl00012 271065009874 active site 271065009875 zinc binding site [ion binding]; other site 271065009876 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 271065009877 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 271065009878 Transposase [DNA replication, recombination, and repair]; Region: COG5433 271065009879 Transposase [DNA replication, recombination, and repair]; Region: COG5433 271065009880 Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA; cd00326 271065009881 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 271065009882 putative hydrophobic ligand binding site [chemical binding]; other site 271065009883 protein interface [polypeptide binding]; other site 271065009884 gate; other site 271065009885 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 271065009886 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 271065009887 Beta-Casp domain; Region: Beta-Casp; cl12567 271065009888 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 271065009889 magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383 271065009890 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 271065009891 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065009892 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 271065009893 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 271065009894 putative active site [active] 271065009895 Zn binding site [ion binding]; other site 271065009896 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 271065009897 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271065009898 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 271065009899 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 271065009900 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271065009901 FeS/SAM binding site; other site 271065009902 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 271065009903 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 271065009904 recombination factor protein RarA; Reviewed; Region: PRK13342 271065009905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065009906 Walker A motif; other site 271065009907 ATP binding site [chemical binding]; other site 271065009908 Walker B motif; other site 271065009909 arginine finger; other site 271065009910 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 271065009911 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 271065009912 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 271065009913 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 271065009914 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 271065009915 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 271065009916 shikimate binding site; other site 271065009917 NAD(P) binding site [chemical binding]; other site 271065009918 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 271065009919 dimer interface [polypeptide binding]; other site 271065009920 allosteric magnesium binding site [ion binding]; other site 271065009921 active site 271065009922 aspartate-rich active site metal binding site; other site 271065009923 Schiff base residues; other site 271065009924 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 271065009925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065009926 S-adenosylmethionine binding site [chemical binding]; other site 271065009927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065009928 S-adenosylmethionine binding site [chemical binding]; other site 271065009929 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271065009930 Helix-turn-helix domains; Region: HTH; cl00088 271065009931 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 271065009932 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 271065009933 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 271065009934 GIY-YIG motif/motif A; other site 271065009935 active site 271065009936 catalytic site [active] 271065009937 putative DNA binding site [nucleotide binding]; other site 271065009938 metal binding site [ion binding]; metal-binding site 271065009939 UvrB/uvrC motif; Region: UVR; pfam02151 271065009940 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 271065009941 potential frameshift: common BLAST hit: gi|333982988|ref|YP_004512198.1| uracil-DNA glycosylase superfamily protein 271065009942 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 271065009943 active site 271065009944 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 271065009945 ligand binding site [chemical binding]; other site 271065009946 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 271065009947 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 271065009948 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 271065009949 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 271065009950 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 271065009951 Predicted amidohydrolase [General function prediction only]; Region: COG0388 271065009952 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 271065009953 putative active site [active] 271065009954 catalytic triad [active] 271065009955 dimer interface [polypeptide binding]; other site 271065009956 TIGR02099 family protein; Region: TIGR02099 271065009957 AsmA-like C-terminal region; Region: AsmA_2; cl15864 271065009958 ribonuclease G; Provisional; Region: PRK11712 271065009959 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 271065009960 homodimer interface [polypeptide binding]; other site 271065009961 oligonucleotide binding site [chemical binding]; other site 271065009962 Maf-like protein; Region: Maf; pfam02545 271065009963 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 271065009964 active site 271065009965 dimer interface [polypeptide binding]; other site 271065009966 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 271065009967 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 271065009968 MoxR-like ATPases [General function prediction only]; Region: COG0714 271065009969 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065009970 Walker A motif; other site 271065009971 ATP binding site [chemical binding]; other site 271065009972 Walker B motif; other site 271065009973 arginine finger; other site 271065009974 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 271065009975 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 271065009976 metal ion-dependent adhesion site (MIDAS); other site 271065009977 Ion transport protein; Region: Ion_trans; pfam00520 271065009978 Ion channel; Region: Ion_trans_2; cl11596 271065009979 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 271065009980 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 271065009981 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 271065009982 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 271065009983 active site 271065009984 HIGH motif; other site 271065009985 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 271065009986 KMSKS motif; other site 271065009987 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 271065009988 tRNA binding surface [nucleotide binding]; other site 271065009989 anticodon binding site; other site 271065009990 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 271065009991 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 271065009992 substrate binding site [chemical binding]; other site 271065009993 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 271065009994 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 271065009995 putative active site [active] 271065009996 putative metal binding site [ion binding]; other site 271065009997 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 271065009998 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 271065009999 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 271065010000 ligand binding site [chemical binding]; other site 271065010001 flexible hinge region; other site 271065010002 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 271065010003 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 271065010004 Trp docking motif [polypeptide binding]; other site 271065010005 dimer interface [polypeptide binding]; other site 271065010006 active site 271065010007 small subunit binding site [polypeptide binding]; other site 271065010008 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 271065010009 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 271065010010 substrate binding pocket [chemical binding]; other site 271065010011 membrane-bound complex binding site; other site 271065010012 hinge residues; other site 271065010013 glycogen branching enzyme; Provisional; Region: PRK05402 271065010014 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 271065010015 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 271065010016 active site 271065010017 catalytic site [active] 271065010018 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 271065010019 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 271065010020 active site 271065010021 catalytic site [active] 271065010022 glycogen synthase; Provisional; Region: glgA; PRK00654 271065010023 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 271065010024 ADP-binding pocket [chemical binding]; other site 271065010025 homodimer interface [polypeptide binding]; other site 271065010026 Uncharacterized conserved protein [Function unknown]; Region: COG1543 271065010027 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 271065010028 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 271065010029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 271065010030 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 271065010031 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 271065010032 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 271065010033 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 271065010034 ligand binding site; other site 271065010035 oligomer interface; other site 271065010036 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 271065010037 dimer interface [polypeptide binding]; other site 271065010038 N-terminal domain interface [polypeptide binding]; other site 271065010039 sulfate 1 binding site; other site 271065010040 glycogen branching enzyme; Provisional; Region: PRK05402 271065010041 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 271065010042 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 271065010043 active site 271065010044 catalytic site [active] 271065010045 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 271065010046 glycogen synthase; Provisional; Region: glgA; PRK00654 271065010047 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 271065010048 ADP-binding pocket [chemical binding]; other site 271065010049 homodimer interface [polypeptide binding]; other site 271065010050 DbpA RNA binding domain; Region: DbpA; pfam03880 271065010051 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 271065010052 SurA N-terminal domain; Region: SurA_N_3; cl07813 271065010053 PPIC-type PPIASE domain; Region: Rotamase; cl08278 271065010054 PPIC-type PPIASE domain; Region: Rotamase; cl08278 271065010055 organic solvent tolerance protein; Provisional; Region: PRK04423 271065010056 Organic solvent tolerance protein; Region: OstA_C; pfam04453 271065010057 Phosphotransferase enzyme family; Region: APH; pfam01636 271065010058 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 271065010059 substrate binding site [chemical binding]; other site 271065010060 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 271065010061 Substrate binding site; other site 271065010062 metal-binding site 271065010063 Dodecin; Region: Dodecin; cl01328 271065010064 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 271065010065 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 271065010066 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 271065010067 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 271065010068 active site 271065010069 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 271065010070 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 271065010071 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 271065010072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065010073 Response regulator receiver domain; Region: Response_reg; pfam00072 271065010074 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065010075 active site 271065010076 phosphorylation site [posttranslational modification] 271065010077 intermolecular recognition site; other site 271065010078 dimerization interface [polypeptide binding]; other site 271065010079 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 271065010080 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 271065010081 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 271065010082 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 271065010083 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 271065010084 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 271065010085 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065010086 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 271065010087 Low affinity iron permease; Region: Iron_permease; cl12096 271065010088 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 271065010089 substrate binding site [chemical binding]; other site 271065010090 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 271065010091 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 271065010092 substrate binding site [chemical binding]; other site 271065010093 ligand binding site [chemical binding]; other site 271065010094 adenylate kinase; Reviewed; Region: adk; PRK00279 271065010095 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 271065010096 AMP-binding site [chemical binding]; other site 271065010097 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 271065010098 FOG: CBS domain [General function prediction only]; Region: COG0517 271065010099 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 271065010100 Protein of unknown function (DUF1415); Region: DUF1415; cl01301 271065010101 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 271065010102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 271065010103 TraB family; Region: TraB; cl12050 271065010104 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 271065010105 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 271065010106 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 271065010107 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 271065010108 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 271065010109 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 271065010110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065010111 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 271065010112 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065010113 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 271065010114 active site 271065010115 HslU subunit interaction site [polypeptide binding]; other site 271065010116 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 271065010117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065010118 Walker A motif; other site 271065010119 ATP binding site [chemical binding]; other site 271065010120 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065010121 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 271065010122 Protein of unknown function (DUF971); Region: DUF971; cl01414 271065010123 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 271065010124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065010125 S-adenosylmethionine binding site [chemical binding]; other site 271065010126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065010127 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 271065010128 SCP-2 sterol transfer family; Region: SCP2; cl01225 271065010129 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 271065010130 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 271065010131 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 271065010132 Phosphoglycerate kinase; Region: PGK; pfam00162 271065010133 substrate binding site [chemical binding]; other site 271065010134 hinge regions; other site 271065010135 ADP binding site [chemical binding]; other site 271065010136 catalytic site [active] 271065010137 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 271065010138 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 271065010139 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 271065010140 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 271065010141 synthetase active site [active] 271065010142 NTP binding site [chemical binding]; other site 271065010143 metal binding site [ion binding]; metal-binding site 271065010144 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 271065010145 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 271065010146 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 271065010147 homotrimer interaction site [polypeptide binding]; other site 271065010148 putative active site [active] 271065010149 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 271065010150 Y-family of DNA polymerases; Region: PolY; cl12025 271065010151 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 271065010152 ssDNA binding site; other site 271065010153 generic binding surface II; other site 271065010154 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271065010155 ATP binding site [chemical binding]; other site 271065010156 putative Mg++ binding site [ion binding]; other site 271065010157 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271065010158 nucleotide binding region [chemical binding]; other site 271065010159 ATP-binding site [chemical binding]; other site 271065010160 UTRA domain; Region: UTRA; cl01230 271065010161 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 271065010162 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 271065010163 inhibitor-cofactor binding pocket; inhibition site 271065010164 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271065010165 catalytic residue [active] 271065010166 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065010167 S-adenosylmethionine binding site [chemical binding]; other site 271065010168 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; cl01548 271065010169 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 271065010170 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 271065010171 dimerization interface [polypeptide binding]; other site 271065010172 active site 271065010173 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 271065010174 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 271065010175 metal binding site [ion binding]; metal-binding site 271065010176 putative dimer interface [polypeptide binding]; other site 271065010177 LexA repressor; Validated; Region: PRK00215 271065010178 Helix-turn-helix domains; Region: HTH; cl00088 271065010179 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 271065010180 Catalytic site [active] 271065010181 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 271065010182 Response regulator receiver domain; Region: Response_reg; pfam00072 271065010183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065010184 active site 271065010185 phosphorylation site [posttranslational modification] 271065010186 intermolecular recognition site; other site 271065010187 dimerization interface [polypeptide binding]; other site 271065010188 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065010189 PAS domain; Region: PAS_9; pfam13426 271065010190 putative active site [active] 271065010191 heme pocket [chemical binding]; other site 271065010192 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065010193 metal binding site [ion binding]; metal-binding site 271065010194 active site 271065010195 I-site; other site 271065010196 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065010197 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 271065010198 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 271065010199 dimerization interface [polypeptide binding]; other site 271065010200 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065010201 dimer interface [polypeptide binding]; other site 271065010202 phosphorylation site [posttranslational modification] 271065010203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065010204 ATP binding site [chemical binding]; other site 271065010205 Mg2+ binding site [ion binding]; other site 271065010206 G-X-G motif; other site 271065010207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065010208 active site 271065010209 phosphorylation site [posttranslational modification] 271065010210 intermolecular recognition site; other site 271065010211 dimerization interface [polypeptide binding]; other site 271065010212 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 271065010213 putative binding surface; other site 271065010214 active site 271065010215 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 271065010216 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 271065010217 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 271065010218 N-terminal plug; other site 271065010219 ligand-binding site [chemical binding]; other site 271065010220 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 271065010221 active site 271065010222 dimerization interface [polypeptide binding]; other site 271065010223 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 271065010224 dimer interface [polypeptide binding]; other site 271065010225 active site 271065010226 HDOD domain; Region: HDOD; pfam08668 271065010227 GAF domain; Region: GAF; cl15785 271065010228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065010229 ATP binding site [chemical binding]; other site 271065010230 Mg2+ binding site [ion binding]; other site 271065010231 G-X-G motif; other site 271065010232 Response regulator receiver domain; Region: Response_reg; pfam00072 271065010233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065010234 active site 271065010235 phosphorylation site [posttranslational modification] 271065010236 intermolecular recognition site; other site 271065010237 dimerization interface [polypeptide binding]; other site 271065010238 PAS domain S-box; Region: sensory_box; TIGR00229 271065010239 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271065010240 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065010241 PAS domain; Region: PAS_9; pfam13426 271065010242 putative active site [active] 271065010243 heme pocket [chemical binding]; other site 271065010244 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065010245 metal binding site [ion binding]; metal-binding site 271065010246 active site 271065010247 I-site; other site 271065010248 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065010249 Zeta toxin; Region: Zeta_toxin; pfam06414 271065010250 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 271065010251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065010252 active site 271065010253 phosphorylation site [posttranslational modification] 271065010254 intermolecular recognition site; other site 271065010255 dimerization interface [polypeptide binding]; other site 271065010256 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271065010257 DNA binding residues [nucleotide binding] 271065010258 dimerization interface [polypeptide binding]; other site 271065010259 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065010260 PAS fold; Region: PAS_3; pfam08447 271065010261 putative active site [active] 271065010262 heme pocket [chemical binding]; other site 271065010263 PAS domain S-box; Region: sensory_box; TIGR00229 271065010264 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065010265 putative active site [active] 271065010266 heme pocket [chemical binding]; other site 271065010267 hypothetical protein; Provisional; Region: PRK13560 271065010268 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065010269 putative active site [active] 271065010270 heme pocket [chemical binding]; other site 271065010271 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 271065010272 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065010273 putative active site [active] 271065010274 heme pocket [chemical binding]; other site 271065010275 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065010276 dimer interface [polypeptide binding]; other site 271065010277 phosphorylation site [posttranslational modification] 271065010278 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065010279 G4 box; other site 271065010280 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065010281 ATP binding site [chemical binding]; other site 271065010282 Mg2+ binding site [ion binding]; other site 271065010283 G-X-G motif; other site 271065010284 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065010285 PAS domain; Region: PAS_9; pfam13426 271065010286 putative active site [active] 271065010287 heme pocket [chemical binding]; other site 271065010288 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065010289 PAS domain; Region: PAS_9; pfam13426 271065010290 putative active site [active] 271065010291 heme pocket [chemical binding]; other site 271065010292 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065010293 metal binding site [ion binding]; metal-binding site 271065010294 active site 271065010295 I-site; other site 271065010296 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065010297 Flavin Reductases; Region: FlaRed; cl00801 271065010298 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 271065010299 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 271065010300 dimerization interface [polypeptide binding]; other site 271065010301 active site 271065010302 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 271065010303 amidase catalytic site [active] 271065010304 Zn binding residues [ion binding]; other site 271065010305 substrate binding site [chemical binding]; other site 271065010306 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 271065010307 lipoprotein signal peptidase; Provisional; Region: PRK14787 271065010308 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 271065010309 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 271065010310 active site 271065010311 HIGH motif; other site 271065010312 nucleotide binding site [chemical binding]; other site 271065010313 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 271065010314 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 271065010315 active site 271065010316 KMSKS motif; other site 271065010317 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 271065010318 tRNA binding surface [nucleotide binding]; other site 271065010319 anticodon binding site; other site 271065010320 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 271065010321 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 271065010322 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 271065010323 active site 271065010324 Riboflavin kinase; Region: Flavokinase; cl03312 271065010325 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 271065010326 gamma-glutamyl kinase; Provisional; Region: PRK05429 271065010327 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 271065010328 nucleotide binding site [chemical binding]; other site 271065010329 homotetrameric interface [polypeptide binding]; other site 271065010330 putative phosphate binding site [ion binding]; other site 271065010331 putative allosteric binding site; other site 271065010332 PUA domain; Region: PUA; cl00607 271065010333 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 271065010334 GTP1/OBG; Region: GTP1_OBG; pfam01018 271065010335 Obg GTPase; Region: Obg; cd01898 271065010336 G1 box; other site 271065010337 GTP/Mg2+ binding site [chemical binding]; other site 271065010338 Switch I region; other site 271065010339 G2 box; other site 271065010340 G3 box; other site 271065010341 Switch II region; other site 271065010342 G4 box; other site 271065010343 G5 box; other site 271065010344 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 271065010345 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 271065010346 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 271065010347 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 271065010348 substrate binding pocket [chemical binding]; other site 271065010349 chain length determination region; other site 271065010350 substrate-Mg2+ binding site; other site 271065010351 catalytic residues [active] 271065010352 aspartate-rich region 1; other site 271065010353 active site lid residues [active] 271065010354 aspartate-rich region 2; other site 271065010355 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 271065010356 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065010357 Walker A motif; other site 271065010358 ATP binding site [chemical binding]; other site 271065010359 Walker B motif; other site 271065010360 arginine finger; other site 271065010361 Helix-turn-helix domains; Region: HTH; cl00088 271065010362 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 271065010363 active site clefts [active] 271065010364 zinc binding site [ion binding]; other site 271065010365 dimer interface [polypeptide binding]; other site 271065010366 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065010367 active site 271065010368 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 271065010369 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 271065010370 cell division protein FtsZ; Validated; Region: PRK09330 271065010371 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 271065010372 nucleotide binding site [chemical binding]; other site 271065010373 SulA interaction site; other site 271065010374 cell division protein FtsA; Region: ftsA; TIGR01174 271065010375 Cell division protein FtsA; Region: FtsA; cl11496 271065010376 Cell division protein FtsA; Region: FtsA; cl11496 271065010377 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 271065010378 Cell division protein FtsQ; Region: FtsQ; pfam03799 271065010379 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 271065010380 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 271065010381 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271065010382 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 271065010383 FAD binding domain; Region: FAD_binding_4; pfam01565 271065010384 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 271065010385 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 271065010386 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 271065010387 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 271065010388 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 271065010389 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 271065010390 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 271065010391 active site 271065010392 homodimer interface [polypeptide binding]; other site 271065010393 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 271065010394 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 271065010395 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 271065010396 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 271065010397 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 271065010398 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 271065010399 Mg++ binding site [ion binding]; other site 271065010400 putative catalytic motif [active] 271065010401 putative substrate binding site [chemical binding]; other site 271065010402 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 271065010403 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 271065010404 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 271065010405 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 271065010406 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 271065010407 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 271065010408 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 271065010409 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 271065010410 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 271065010411 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 271065010412 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 271065010413 Septum formation initiator; Region: DivIC; cl11433 271065010414 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065010415 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 271065010416 MraZ protein; Region: MraZ; pfam02381 271065010417 MraZ protein; Region: MraZ; pfam02381 271065010418 Predicted methyltransferases [General function prediction only]; Region: COG0313 271065010419 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 271065010420 LppC putative lipoprotein; Region: LppC; pfam04348 271065010421 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 271065010422 putative ligand binding site [chemical binding]; other site 271065010423 Restriction endonuclease; Region: Mrr_cat; cl00516 271065010424 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 271065010425 dimer interface [polypeptide binding]; other site 271065010426 active site 271065010427 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 271065010428 RmuC family; Region: RmuC; pfam02646 271065010429 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065010430 Family description; Region: UvrD_C_2; cl15862 271065010431 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 271065010432 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 271065010433 Family description; Region: UvrD_C_2; cl15862 271065010434 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 271065010435 Sporulation related domain; Region: SPOR; cl10051 271065010436 FtsH Extracellular; Region: FtsH_ext; pfam06480 271065010437 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 271065010438 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065010439 Walker A motif; other site 271065010440 ATP binding site [chemical binding]; other site 271065010441 Walker B motif; other site 271065010442 arginine finger; other site 271065010443 Peptidase family M41; Region: Peptidase_M41; pfam01434 271065010444 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 271065010445 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 271065010446 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 271065010447 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 271065010448 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065010449 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 271065010450 active site 271065010451 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 271065010452 active sites [active] 271065010453 tetramer interface [polypeptide binding]; other site 271065010454 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 271065010455 putative active site [active] 271065010456 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 271065010457 putative acyl-acceptor binding pocket; other site 271065010458 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 271065010459 Ligand binding site; other site 271065010460 Putative Catalytic site; other site 271065010461 DXD motif; other site 271065010462 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 271065010463 AMP-binding enzyme; Region: AMP-binding; cl15778 271065010464 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 271065010465 active site 2 [active] 271065010466 dimer interface [polypeptide binding]; other site 271065010467 active site 1 [active] 271065010468 Predicted membrane protein [Function unknown]; Region: COG4648 271065010469 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271065010470 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271065010471 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 271065010472 hypothetical protein; Provisional; Region: PRK11820 271065010473 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 271065010474 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 271065010475 Catalytic domain of Protein Kinases; Region: PKc; cd00180 271065010476 active site 271065010477 ATP binding site [chemical binding]; other site 271065010478 substrate binding site [chemical binding]; other site 271065010479 activation loop (A-loop); other site 271065010480 ribonuclease PH; Reviewed; Region: rph; PRK00173 271065010481 Ribonuclease PH; Region: RNase_PH_bact; cd11362 271065010482 hexamer interface [polypeptide binding]; other site 271065010483 active site 271065010484 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 271065010485 active site 271065010486 dimerization interface [polypeptide binding]; other site 271065010487 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 271065010488 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 271065010489 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 271065010490 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 271065010491 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 271065010492 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 271065010493 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 271065010494 ferrochelatase; Reviewed; Region: hemH; PRK00035 271065010495 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 271065010496 C-terminal domain interface [polypeptide binding]; other site 271065010497 active site 271065010498 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 271065010499 active site 271065010500 N-terminal domain interface [polypeptide binding]; other site 271065010501 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 271065010502 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 271065010503 N-terminal plug; other site 271065010504 ligand-binding site [chemical binding]; other site 271065010505 Predicted membrane protein [Function unknown]; Region: COG3212 271065010506 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 271065010507 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 271065010508 VacJ like lipoprotein; Region: VacJ; cl01073 271065010509 Membrane transport protein; Region: Mem_trans; cl09117 271065010510 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 271065010511 active site 271065010512 Cytochrome c; Region: Cytochrom_C; cl11414 271065010513 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 271065010514 AMMECR1; Region: AMMECR1; cl00911 271065010515 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 271065010516 putative ligand binding pocket/active site [active] 271065010517 putative metal binding site [ion binding]; other site 271065010518 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 271065010519 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271065010520 FeS/SAM binding site; other site 271065010521 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 271065010522 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 271065010523 FtsX-like permease family; Region: FtsX; cl15850 271065010524 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 271065010525 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 271065010526 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271065010527 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 271065010528 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 271065010529 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 271065010530 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065010531 Family description; Region: UvrD_C_2; cl15862 271065010532 Rhomboid family; Region: Rhomboid; cl11446 271065010533 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 271065010534 putative active site [active] 271065010535 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 271065010536 Putative addiction module component; Region: Unstab_antitox; cl09921 271065010537 Predicted membrane protein [Function unknown]; Region: COG4648 271065010538 Predicted exporter [General function prediction only]; Region: COG4258 271065010539 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 271065010540 HsdM N-terminal domain; Region: HsdM_N; pfam12161 271065010541 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065010542 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 271065010543 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 271065010544 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 271065010545 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 271065010546 Protein of unknown function DUF91; Region: DUF91; cl00709 271065010547 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 271065010548 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 271065010549 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 271065010550 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 271065010551 Integrase core domain; Region: rve; cl01316 271065010552 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 271065010553 Fic/DOC family; Region: Fic; cl00960 271065010554 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 271065010555 Helix-turn-helix domains; Region: HTH; cl00088 271065010556 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 271065010557 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 271065010558 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271065010559 ATP binding site [chemical binding]; other site 271065010560 putative Mg++ binding site [ion binding]; other site 271065010561 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 271065010562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065010563 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065010564 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 271065010565 dimerization interface [polypeptide binding]; other site 271065010566 GAF domain; Region: GAF_2; pfam13185 271065010567 GAF domain; Region: GAF; cl15785 271065010568 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065010569 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 271065010570 putative active site [active] 271065010571 heme pocket [chemical binding]; other site 271065010572 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065010573 dimer interface [polypeptide binding]; other site 271065010574 phosphorylation site [posttranslational modification] 271065010575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065010576 ATP binding site [chemical binding]; other site 271065010577 Mg2+ binding site [ion binding]; other site 271065010578 G-X-G motif; other site 271065010579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065010580 Response regulator receiver domain; Region: Response_reg; pfam00072 271065010581 active site 271065010582 phosphorylation site [posttranslational modification] 271065010583 intermolecular recognition site; other site 271065010584 dimerization interface [polypeptide binding]; other site 271065010585 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 271065010586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065010587 active site 271065010588 phosphorylation site [posttranslational modification] 271065010589 intermolecular recognition site; other site 271065010590 dimerization interface [polypeptide binding]; other site 271065010591 Response regulator receiver domain; Region: Response_reg; pfam00072 271065010592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065010593 active site 271065010594 phosphorylation site [posttranslational modification] 271065010595 intermolecular recognition site; other site 271065010596 dimerization interface [polypeptide binding]; other site 271065010597 Response regulator receiver domain; Region: Response_reg; pfam00072 271065010598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065010599 active site 271065010600 phosphorylation site [posttranslational modification] 271065010601 intermolecular recognition site; other site 271065010602 dimerization interface [polypeptide binding]; other site 271065010603 GAF domain; Region: GAF_2; pfam13185 271065010604 GAF domain; Region: GAF; cl15785 271065010605 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065010606 metal binding site [ion binding]; metal-binding site 271065010607 active site 271065010608 I-site; other site 271065010609 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065010610 Response regulator receiver domain; Region: Response_reg; pfam00072 271065010611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065010612 active site 271065010613 phosphorylation site [posttranslational modification] 271065010614 intermolecular recognition site; other site 271065010615 dimerization interface [polypeptide binding]; other site 271065010616 putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073 271065010617 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 271065010618 Sel1 repeat; Region: Sel1; cl02723 271065010619 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 271065010620 N-acetyl-D-glucosamine binding site [chemical binding]; other site 271065010621 catalytic residue [active] 271065010622 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065010623 metal binding site [ion binding]; metal-binding site 271065010624 active site 271065010625 I-site; other site 271065010626 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065010627 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 271065010628 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 271065010629 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 271065010630 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 271065010631 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39_likeD; cd02421 271065010632 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 271065010633 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 271065010634 ABC-type bacteriocin exporters. Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors which have N-terminal leader peptides that share similarities in amino acid sequence and contain a conserved processing site of two...; Region: ABCC_bacteriocin_exporters; cd03245 271065010635 Walker A/P-loop; other site 271065010636 ATP binding site [chemical binding]; other site 271065010637 Q-loop/lid; other site 271065010638 ABC transporter signature motif; other site 271065010639 Walker B; other site 271065010640 D-loop; other site 271065010641 H-loop/switch region; other site 271065010642 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 271065010643 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271065010644 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271065010645 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 271065010646 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271065010647 DNA binding residues [nucleotide binding] 271065010648 dimerization interface [polypeptide binding]; other site 271065010649 transposase; Provisional; Region: PRK06526 271065010650 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065010651 Walker A motif; other site 271065010652 ATP binding site [chemical binding]; other site 271065010653 Walker B motif; other site 271065010654 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 271065010655 Integrase core domain; Region: rve; cl01316 271065010656 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 271065010657 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065010658 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271065010659 binding surface 271065010660 Tetratricopeptide repeat; Region: TPR_16; pfam13432 271065010661 TPR motif; other site 271065010662 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 271065010663 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 271065010664 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 271065010665 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 271065010666 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 271065010667 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 271065010668 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 271065010669 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 271065010670 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 271065010671 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 271065010672 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 271065010673 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 271065010674 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 271065010675 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 271065010676 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 271065010677 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 271065010678 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cl09719 271065010679 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 271065010680 helicase Cas3; Provisional; Region: PRK09694 271065010681 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 271065010682 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065010683 Predicted transcriptional regulator [Transcription]; Region: COG2378 271065010684 WYL domain; Region: WYL; cl14852 271065010685 PAS domain S-box; Region: sensory_box; TIGR00229 271065010686 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065010687 putative active site [active] 271065010688 heme pocket [chemical binding]; other site 271065010689 PAS fold; Region: PAS_3; pfam08447 271065010690 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 271065010691 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065010692 PAS domain; Region: PAS_9; pfam13426 271065010693 putative active site [active] 271065010694 heme pocket [chemical binding]; other site 271065010695 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065010696 metal binding site [ion binding]; metal-binding site 271065010697 active site 271065010698 I-site; other site 271065010699 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065010700 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 271065010701 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 271065010702 nickel binding site [ion binding]; other site 271065010703 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 271065010704 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 271065010705 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 271065010706 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 271065010707 Domain of unknown function (DUF336); Region: DUF336; cl01249 271065010708 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 271065010709 active site 271065010710 catalytic triad [active] 271065010711 oxyanion hole [active] 271065010712 switch loop; other site 271065010713 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 271065010714 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 271065010715 Walker A/P-loop; other site 271065010716 ATP binding site [chemical binding]; other site 271065010717 Q-loop/lid; other site 271065010718 ABC transporter signature motif; other site 271065010719 Walker B; other site 271065010720 D-loop; other site 271065010721 H-loop/switch region; other site 271065010722 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 271065010723 FtsX-like permease family; Region: FtsX; cl15850 271065010724 FtsX-like permease family; Region: FtsX; cl15850 271065010725 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065010726 PAS fold; Region: PAS_3; pfam08447 271065010727 putative active site [active] 271065010728 heme pocket [chemical binding]; other site 271065010729 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 271065010730 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271065010731 dimer interface [polypeptide binding]; other site 271065010732 putative CheW interface [polypeptide binding]; other site 271065010733 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 271065010734 alternate F1F0 ATPase, F1 subunit beta; Region: alt_F1F0_F1_bet; TIGR03305 271065010735 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 271065010736 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 271065010737 alpha subunit interaction interface [polypeptide binding]; other site 271065010738 Walker A motif; other site 271065010739 ATP binding site [chemical binding]; other site 271065010740 Walker B motif; other site 271065010741 inhibitor binding site; inhibition site 271065010742 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 271065010743 F0F1 ATP synthase subunit epsilon; Validated; Region: PRK06228 271065010744 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 271065010745 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 271065010746 N-ATPase, AtpR subunit; Region: AtpR; cl11871 271065010747 ATP synthase A chain; Region: ATP-synt_A; cl00413 271065010748 ATP synthase subunit C; Region: ATP-synt_C; cl00466 271065010749 alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321 271065010750 Plant ATP synthase F0; Region: YMF19; cl07975 271065010751 alternate F1F0 ATPase, F1 subunit alpha; Region: alt_F1F0_F1_al; TIGR03324 271065010752 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 271065010753 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 271065010754 beta subunit interaction interface [polypeptide binding]; other site 271065010755 Walker A motif; other site 271065010756 ATP binding site [chemical binding]; other site 271065010757 Walker B motif; other site 271065010758 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 271065010759 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 271065010760 ATP synthase; Region: ATP-synt; cl00365 271065010761 Winged helix-turn helix; Region: HTH_29; pfam13551 271065010762 Helix-turn-helix domains; Region: HTH; cl00088 271065010763 Integrase core domain; Region: rve; cl01316 271065010764 Integrase core domain; Region: rve_3; cl15866 271065010765 Helix-turn-helix domains; Region: HTH; cl00088 271065010766 rod shape-determining protein MreC; Provisional; Region: PRK13922 271065010767 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 271065010768 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 271065010769 nucleoside/Zn binding site; other site 271065010770 dimer interface [polypeptide binding]; other site 271065010771 catalytic motif [active] 271065010772 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 271065010773 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 271065010774 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 271065010775 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 271065010776 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 271065010777 FMN binding site [chemical binding]; other site 271065010778 active site 271065010779 substrate binding site [chemical binding]; other site 271065010780 catalytic residue [active] 271065010781 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065010782 PAS fold; Region: PAS_3; pfam08447 271065010783 putative active site [active] 271065010784 heme pocket [chemical binding]; other site 271065010785 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 271065010786 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271065010787 dimer interface [polypeptide binding]; other site 271065010788 putative CheW interface [polypeptide binding]; other site 271065010789 AAA domain; Region: AAA_32; pfam13654 271065010790 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 271065010791 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271065010792 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 271065010793 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065010794 Walker A motif; other site 271065010795 ATP binding site [chemical binding]; other site 271065010796 Walker B motif; other site 271065010797 Helix-turn-helix domains; Region: HTH; cl00088 271065010798 HDOD domain; Region: HDOD; pfam08668 271065010799 Transposase domain (DUF772); Region: DUF772; cl15789 271065010800 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 271065010801 Transposase domain (DUF772); Region: DUF772; cl15789 271065010802 antiporter inner membrane protein; Provisional; Region: PRK11670 271065010803 Domain of unknown function DUF59; Region: DUF59; cl00941 271065010804 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 271065010805 Walker A motif; other site 271065010806 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 271065010807 trimer interface [polypeptide binding]; other site 271065010808 active site 271065010809 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 271065010810 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 271065010811 Walker A/P-loop; other site 271065010812 ATP binding site [chemical binding]; other site 271065010813 Q-loop/lid; other site 271065010814 ABC transporter signature motif; other site 271065010815 Walker B; other site 271065010816 D-loop; other site 271065010817 H-loop/switch region; other site 271065010818 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 271065010819 ABC-ATPase subunit interface; other site 271065010820 dimer interface [polypeptide binding]; other site 271065010821 putative PBP binding regions; other site 271065010822 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 271065010823 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 271065010824 putative hemin binding site; other site 271065010825 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 271065010826 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 271065010827 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 271065010828 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 271065010829 kelch-like protein; Provisional; Region: PHA03098 271065010830 Kelch motif; Region: Kelch_1; cl02701 271065010831 Kelch motif; Region: Kelch_1; cl02701 271065010832 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 271065010833 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 271065010834 N-terminal plug; other site 271065010835 ligand-binding site [chemical binding]; other site 271065010836 Reovirus core-spike protein lambda-2 (L2); Region: Reovirus_L2; pfam06016 271065010837 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 271065010838 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 271065010839 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271065010840 DNA binding residues [nucleotide binding] 271065010841 dimerization interface [polypeptide binding]; other site 271065010842 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 271065010843 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 271065010844 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 271065010845 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 271065010846 Probable Catalytic site; other site 271065010847 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 271065010848 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271065010849 active site 271065010850 Int/Topo IB signature motif; other site 271065010851 DNA binding site [nucleotide binding] 271065010852 Uncharacterized conserved protein [Function unknown]; Region: COG4715 271065010853 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 271065010854 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271065010855 ATP binding site [chemical binding]; other site 271065010856 putative Mg++ binding site [ion binding]; other site 271065010857 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271065010858 nucleotide binding region [chemical binding]; other site 271065010859 ATP-binding site [chemical binding]; other site 271065010860 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 271065010861 integrase; Provisional; Region: int; PHA02601 271065010862 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271065010863 active site 271065010864 DNA binding site [nucleotide binding] 271065010865 Int/Topo IB signature motif; other site 271065010866 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 271065010867 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 271065010868 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 271065010869 active site 271065010870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065010871 S-adenosylmethionine binding site [chemical binding]; other site 271065010872 hypothetical protein; Provisional; Region: PRK08185 271065010873 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 271065010874 intersubunit interface [polypeptide binding]; other site 271065010875 active site 271065010876 zinc binding site [ion binding]; other site 271065010877 Na+ binding site [ion binding]; other site 271065010878 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 271065010879 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 271065010880 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 271065010881 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 271065010882 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 271065010883 Transposase IS200 like; Region: Y1_Tnp; cl00848 271065010884 OpgC protein; Region: OpgC_C; cl00792 271065010885 Acyltransferase family; Region: Acyl_transf_3; pfam01757 271065010886 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 271065010887 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 271065010888 Protein of unknown function, DUF393; Region: DUF393; cl01136 271065010889 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 271065010890 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 271065010891 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 271065010892 FAD binding pocket [chemical binding]; other site 271065010893 FAD binding motif [chemical binding]; other site 271065010894 catalytic residues [active] 271065010895 NAD binding pocket [chemical binding]; other site 271065010896 phosphate binding motif [ion binding]; other site 271065010897 beta-alpha-beta structure motif; other site 271065010898 sulfite reductase subunit beta; Provisional; Region: PRK13504 271065010899 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 271065010900 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 271065010901 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 271065010902 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 271065010903 active site 271065010904 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 271065010905 putative active site [active] 271065010906 putative metal binding site [ion binding]; other site 271065010907 Protein of unknown function (DUF3014); Region: DUF3014; pfam11219 271065010908 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 271065010909 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 271065010910 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 271065010911 PAS fold; Region: PAS_3; pfam08447 271065010912 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 271065010913 PAS domain; Region: PAS_9; pfam13426 271065010914 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065010915 metal binding site [ion binding]; metal-binding site 271065010916 active site 271065010917 I-site; other site 271065010918 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065010919 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 271065010920 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 271065010921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 271065010922 Protein of unknown function (DUF330); Region: DUF330; cl01135 271065010923 mce related protein; Region: MCE; pfam02470 271065010924 paraquat-inducible protein B; Provisional; Region: PRK10807 271065010925 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 271065010926 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 271065010927 Walker A/P-loop; other site 271065010928 ATP binding site [chemical binding]; other site 271065010929 Q-loop/lid; other site 271065010930 ABC transporter signature motif; other site 271065010931 Walker B; other site 271065010932 D-loop; other site 271065010933 H-loop/switch region; other site 271065010934 Permease; Region: Permease; cl00510 271065010935 Cytochrome c [Energy production and conversion]; Region: COG3258 271065010936 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 271065010937 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 271065010938 active site 271065010939 metal binding site [ion binding]; metal-binding site 271065010940 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 271065010941 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 271065010942 PAS domain S-box; Region: sensory_box; TIGR00229 271065010943 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065010944 putative active site [active] 271065010945 heme pocket [chemical binding]; other site 271065010946 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065010947 PAS domain; Region: PAS_9; pfam13426 271065010948 putative active site [active] 271065010949 heme pocket [chemical binding]; other site 271065010950 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065010951 metal binding site [ion binding]; metal-binding site 271065010952 active site 271065010953 I-site; other site 271065010954 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271065010955 CheB methylesterase; Region: CheB_methylest; pfam01339 271065010956 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 271065010957 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 271065010958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065010959 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 271065010960 PAS domain; Region: PAS_10; pfam13596 271065010961 PAS domain S-box; Region: sensory_box; TIGR00229 271065010962 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065010963 putative active site [active] 271065010964 heme pocket [chemical binding]; other site 271065010965 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271065010966 PAS domain; Region: PAS_9; pfam13426 271065010967 putative active site [active] 271065010968 heme pocket [chemical binding]; other site 271065010969 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 271065010970 active site 271065010971 homodimer interface [polypeptide binding]; other site 271065010972 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 271065010973 NADP+ binding site [chemical binding]; other site 271065010974 folate binding site [chemical binding]; other site 271065010975 multicopper oxidase; Provisional; Region: PRK10965 271065010976 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271065010977 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271065010978 Divergent AAA domain; Region: AAA_4; pfam04326 271065010979 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 271065010980 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 271065010981 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 271065010982 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 271065010983 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 271065010984 active site 271065010985 metal binding site [ion binding]; metal-binding site 271065010986 Protein of unknown function (DUF525); Region: DUF525; cl01119 271065010987 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 271065010988 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 271065010989 Helix-turn-helix domains; Region: HTH; cl00088 271065010990 rod shape-determining protein MreC; Provisional; Region: PRK13922 271065010991 Winged helix-turn helix; Region: HTH_29; pfam13551 271065010992 Helix-turn-helix domains; Region: HTH; cl00088 271065010993 Integrase core domain; Region: rve; cl01316 271065010994 Integrase core domain; Region: rve_3; cl15866 271065010995 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 271065010996 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 271065010997 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271065010998 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271065010999 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 271065011000 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 271065011001 Walker A/P-loop; other site 271065011002 ATP binding site [chemical binding]; other site 271065011003 Q-loop/lid; other site 271065011004 ABC transporter signature motif; other site 271065011005 Walker B; other site 271065011006 D-loop; other site 271065011007 H-loop/switch region; other site 271065011008 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 271065011009 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 271065011010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065011011 active site 271065011012 phosphorylation site [posttranslational modification] 271065011013 intermolecular recognition site; other site 271065011014 dimerization interface [polypeptide binding]; other site 271065011015 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 271065011016 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065011017 active site 271065011018 phosphorylation site [posttranslational modification] 271065011019 intermolecular recognition site; other site 271065011020 dimerization interface [polypeptide binding]; other site 271065011021 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 271065011022 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 271065011023 dimerization interface [polypeptide binding]; other site 271065011024 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065011025 dimer interface [polypeptide binding]; other site 271065011026 phosphorylation site [posttranslational modification] 271065011027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065011028 ATP binding site [chemical binding]; other site 271065011029 Mg2+ binding site [ion binding]; other site 271065011030 G-X-G motif; other site 271065011031 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 271065011032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065011033 active site 271065011034 phosphorylation site [posttranslational modification] 271065011035 intermolecular recognition site; other site 271065011036 dimerization interface [polypeptide binding]; other site 271065011037 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271065011038 DNA binding site [nucleotide binding] 271065011039 Winged helix-turn helix; Region: HTH_29; pfam13551 271065011040 Helix-turn-helix domains; Region: HTH; cl00088 271065011041 Integrase core domain; Region: rve; cl01316 271065011042 Integrase core domain; Region: rve_3; cl15866 271065011043 Helix-turn-helix domains; Region: HTH; cl00088 271065011044 rod shape-determining protein MreC; Provisional; Region: PRK13922 271065011045 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 271065011046 putative active site [active] 271065011047 M28 Zn-Peptidases; Region: M28_like_1; cd05640 271065011048 metal binding site [ion binding]; metal-binding site 271065011049 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 271065011050 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 271065011051 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 271065011052 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 271065011053 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 271065011054 translocation protein TolB; Provisional; Region: tolB; PRK01742 271065011055 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 271065011056 Carbon starvation protein CstA; Region: CstA; pfam02554 271065011057 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 271065011058 arsenite-activated ATPase ArsA; Region: arsA; TIGR00345 271065011059 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 271065011060 DTAP/Switch II; other site 271065011061 Switch I; other site 271065011062 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 271065011063 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 271065011064 DNA ligase; Provisional; Region: PRK09125 271065011065 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 271065011066 DNA binding site [nucleotide binding] 271065011067 active site 271065011068 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 271065011069 DNA binding site [nucleotide binding] 271065011070 AsmA-like C-terminal region; Region: AsmA_2; cl15864 271065011071 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271065011072 metal binding site [ion binding]; metal-binding site 271065011073 active site 271065011074 I-site; other site 271065011075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065011076 S-adenosylmethionine binding site [chemical binding]; other site 271065011077 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ; Region: Rsd_AlgQ; cl11478 271065011078 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 271065011079 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 271065011080 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 271065011081 aminopeptidase N; Provisional; Region: pepN; PRK14015 271065011082 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 271065011083 active site 271065011084 Zn binding site [ion binding]; other site 271065011085 Protein of unknown function (DUF423); Region: DUF423; cl01008 271065011086 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 271065011087 MPT binding site; other site 271065011088 trimer interface [polypeptide binding]; other site 271065011089 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 271065011090 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 271065011091 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 271065011092 protein binding site [polypeptide binding]; other site 271065011093 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 271065011094 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 271065011095 ligand binding site [chemical binding]; other site 271065011096 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 271065011097 ligand binding site [chemical binding]; other site 271065011098 flexible hinge region; other site 271065011099 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 271065011100 active site residue [active] 271065011101 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 271065011102 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 271065011103 glutathione synthetase; Provisional; Region: PRK05246 271065011104 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 271065011105 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271065011106 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 271065011107 Gram-negative bacterial tonB protein; Region: TonB; cl10048 271065011108 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 271065011109 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 271065011110 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 271065011111 active site 271065011112 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 271065011113 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 271065011114 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065011115 dihydroorotase; Validated; Region: pyrC; PRK09357 271065011116 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 271065011117 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 271065011118 active site 271065011119 Cytochrome c; Region: Cytochrom_C; cl11414 271065011120 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 271065011121 galactonolactone dehydrogenase; Region: GLDHase; TIGR01676 271065011122 FAD binding domain; Region: FAD_binding_4; pfam01565 271065011123 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 271065011124 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271065011125 two-component sensor protein; Provisional; Region: cpxA; PRK09470 271065011126 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271065011127 dimer interface [polypeptide binding]; other site 271065011128 phosphorylation site [posttranslational modification] 271065011129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271065011130 ATP binding site [chemical binding]; other site 271065011131 Mg2+ binding site [ion binding]; other site 271065011132 G-X-G motif; other site 271065011133 Phospholipid methyltransferase; Region: PEMT; cl00763 271065011134 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 271065011135 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065011136 S-adenosylmethionine binding site [chemical binding]; other site 271065011137 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 271065011138 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 271065011139 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065011140 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065011141 S-adenosylmethionine binding site [chemical binding]; other site 271065011142 Uncharacterized conserved protein [Function unknown]; Region: COG3496 271065011143 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 271065011144 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 271065011145 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065011146 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 271065011147 Di-iron ligands [ion binding]; other site 271065011148 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 271065011149 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 271065011150 Protein of unknown function (DUF497); Region: DUF497; cl01108 271065011151 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 271065011152 Mechanosensitive ion channel; Region: MS_channel; pfam00924 271065011153 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 271065011154 PemK-like protein; Region: PemK; cl00995 271065011155 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 271065011156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271065011157 S-adenosylmethionine binding site [chemical binding]; other site 271065011158 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 271065011159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271065011160 active site 271065011161 phosphorylation site [posttranslational modification] 271065011162 intermolecular recognition site; other site 271065011163 dimerization interface [polypeptide binding]; other site 271065011164 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271065011165 DNA binding site [nucleotide binding] 271065011166 Tim44-like domain; Region: Tim44; cl09208 271065011167 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 271065011168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271065011169 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 271065011170 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 271065011171 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 271065011172 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 271065011173 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 271065011174 classical (c) SDRs; Region: SDR_c; cd05233 271065011175 NAD(P) binding site [chemical binding]; other site 271065011176 active site 271065011177 FAD dependent oxidoreductase; Region: DAO; pfam01266 271065011178 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 271065011179 Protein of unknown function (DUF497); Region: DUF497; cl01108 271065011180 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271065011181 non-specific DNA binding site [nucleotide binding]; other site 271065011182 salt bridge; other site 271065011183 sequence-specific DNA binding site [nucleotide binding]; other site 271065011184 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 271065011185 Predicted membrane protein [Function unknown]; Region: COG3748 271065011186 Protein of unknown function (DUF989); Region: DUF989; pfam06181 271065011187 ferredoxin; Validated; Region: PRK07118 271065011188 Putative Fe-S cluster; Region: FeS; pfam04060 271065011189 4Fe-4S binding domain; Region: Fer4; cl02805 271065011190 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 271065011191 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 271065011192 FAD binding pocket [chemical binding]; other site 271065011193 conserved FAD binding motif [chemical binding]; other site 271065011194 phosphate binding motif [ion binding]; other site 271065011195 beta-alpha-beta structure motif; other site 271065011196 NAD binding pocket [chemical binding]; other site 271065011197 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 271065011198 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 271065011199 FMN-binding domain; Region: FMN_bind; cl01081 271065011200 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 271065011201 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 271065011202 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 271065011203 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 271065011204 SLBB domain; Region: SLBB; pfam10531 271065011205 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 271065011206 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 271065011207 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 271065011208 dimer interface [polypeptide binding]; other site 271065011209 PYR/PP interface [polypeptide binding]; other site 271065011210 TPP binding site [chemical binding]; other site 271065011211 substrate binding site [chemical binding]; other site 271065011212 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 271065011213 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 271065011214 TPP-binding site [chemical binding]; other site 271065011215 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 271065011216 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 271065011217 Sodium:solute symporter family; Region: SSF; cl00456 271065011218 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 271065011219 Cupin domain; Region: Cupin_2; cl09118 271065011220 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 271065011221 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 271065011222 metal-binding site [ion binding] 271065011223 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 271065011224 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271065011225 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 271065011226 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271065011227 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 271065011228 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 271065011229 active site residue [active] 271065011230 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 271065011231 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 271065011232 active site 271065011233 intersubunit interface [polypeptide binding]; other site 271065011234 zinc binding site [ion binding]; other site 271065011235 Na+ binding site [ion binding]; other site 271065011236 transaldolase-like protein; Provisional; Region: PTZ00411 271065011237 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 271065011238 active site 271065011239 dimer interface [polypeptide binding]; other site 271065011240 catalytic residue [active] 271065011241 transketolase; Reviewed; Region: PRK12753 271065011242 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 271065011243 TPP-binding site [chemical binding]; other site 271065011244 dimer interface [polypeptide binding]; other site 271065011245 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 271065011246 PYR/PP interface [polypeptide binding]; other site 271065011247 dimer interface [polypeptide binding]; other site 271065011248 TPP binding site [chemical binding]; other site 271065011249 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 271065011250 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 271065011251 tetramer interface [polypeptide binding]; other site 271065011252 active site 271065011253 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 271065011254 active site 271065011255 dimer interface [polypeptide binding]; other site 271065011256 magnesium binding site [ion binding]; other site 271065011257 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 271065011258 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271065011259 active site 271065011260 motif I; other site 271065011261 motif II; other site 271065011262 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271065011263 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 271065011264 Dak1 domain; Region: Dak1; pfam02733 271065011265 DAK2 domain; Region: Dak2; cl03685 271065011266 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 271065011267 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 271065011268 dimer interface [polypeptide binding]; other site 271065011269 ADP-ribose binding site [chemical binding]; other site 271065011270 active site 271065011271 nudix motif; other site 271065011272 metal binding site [ion binding]; metal-binding site 271065011273 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271065011274 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 271065011275 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 271065011276 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 271065011277 ATP binding site [chemical binding]; other site 271065011278 Mg++ binding site [ion binding]; other site 271065011279 motif III; other site 271065011280 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271065011281 nucleotide binding region [chemical binding]; other site 271065011282 ATP-binding site [chemical binding]; other site 271065011283 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 271065011284 catalytic residues [active] 271065011285 transcription termination factor Rho; Provisional; Region: rho; PRK09376 271065011286 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 271065011287 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 271065011288 RNA binding site [nucleotide binding]; other site 271065011289 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 271065011290 multimer interface [polypeptide binding]; other site 271065011291 Walker A motif; other site 271065011292 ATP binding site [chemical binding]; other site 271065011293 Walker B motif; other site 271065011294 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104 271065011295 adenine DNA glycosylase; Provisional; Region: PRK10880 271065011296 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 271065011297 minor groove reading motif; other site 271065011298 helix-hairpin-helix signature motif; other site 271065011299 substrate binding pocket [chemical binding]; other site 271065011300 active site 271065011301 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 271065011302 DNA binding and oxoG recognition site [nucleotide binding] 271065011303 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 271065011304 Rubredoxin; Region: Rubredoxin; pfam00301 271065011305 iron binding site [ion binding]; other site 271065011306 AsmA family; Region: AsmA; pfam05170 271065011307 AsmA-like C-terminal region; Region: AsmA_2; cl15864 271065011308 peroxidase; Provisional; Region: PRK15000 271065011309 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 271065011310 dimer interface [polypeptide binding]; other site 271065011311 decamer (pentamer of dimers) interface [polypeptide binding]; other site 271065011312 catalytic triad [active] 271065011313 peroxidatic and resolving cysteines [active] 271065011314 Tetratricopeptide repeat; Region: TPR_12; pfam13424 271065011315 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271065011316 binding surface 271065011317 TPR motif; other site 271065011318 TPR repeat; Region: TPR_11; pfam13414 271065011319 Gram-negative bacterial tonB protein; Region: TonB; cl10048 271065011320 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 271065011321 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 271065011322 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 271065011323 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 271065011324 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 271065011325 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 271065011326 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 271065011327 metal binding site [ion binding]; metal-binding site 271065011328 dimer interface [polypeptide binding]; other site 271065011329 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 271065011330 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 271065011331 inhibitor-cofactor binding pocket; inhibition site 271065011332 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271065011333 catalytic residue [active] 271065011334 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 271065011335 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 271065011336 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 271065011337 active site 271065011338 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 271065011339 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 271065011340 NAD(P) binding site [chemical binding]; other site 271065011341 catalytic residues [active] 271065011342 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 271065011343 Transposase IS200 like; Region: Y1_Tnp; cl00848 271065011344 Gram-negative bacterial tonB protein; Region: TonB; cl10048 271065011345 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 271065011346 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 271065011347 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 271065011348 hypothetical protein; Provisional; Region: PRK11281 271065011349 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 271065011350 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 271065011351 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 271065011352 Winged helix-turn helix; Region: HTH_29; pfam13551 271065011353 Helix-turn-helix domains; Region: HTH; cl00088 271065011354 Integrase core domain; Region: rve; cl01316 271065011355 Integrase core domain; Region: rve_3; cl15866 271065011356 Helix-turn-helix domains; Region: HTH; cl00088 271065011357 rod shape-determining protein MreC; Provisional; Region: PRK13922 271065011358 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 271065011359 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 271065011360 substrate binding site [chemical binding]; other site 271065011361 hexamer interface [polypeptide binding]; other site 271065011362 metal binding site [ion binding]; metal-binding site 271065011363 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 271065011364 putative homodimer interface [polypeptide binding]; other site 271065011365 putative active site pocket [active] 271065011366 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 271065011367 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 271065011368 MgtE intracellular N domain; Region: MgtE_N; cl15244 271065011369 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 271065011370 Divalent cation transporter; Region: MgtE; cl00786 271065011371 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 271065011372 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 271065011373 DNA binding residues [nucleotide binding] 271065011374 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 271065011375 B12 binding site [chemical binding]; other site 271065011376 chemotaxis protein; Reviewed; Region: PRK12798 271065011377 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 271065011378 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271065011379 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 271065011380 DNA binding residues [nucleotide binding] 271065011381 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 271065011382 HflK protein; Region: hflK; TIGR01933 271065011383 FtsH protease regulator HflC; Provisional; Region: PRK11029 271065011384 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 271065011385 FtsH Extracellular; Region: FtsH_ext; pfam06480 271065011386 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 271065011387 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271065011388 Walker A motif; other site 271065011389 ATP binding site [chemical binding]; other site 271065011390 Walker B motif; other site 271065011391 arginine finger; other site 271065011392 Peptidase family M41; Region: Peptidase_M41; pfam01434 271065011393 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 271065011394 TIGR01777 family protein; Region: yfcH 271065011395 putative NAD(P) binding site [chemical binding]; other site 271065011396 putative active site [active] 271065011397 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 271065011398 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 271065011399 active site 271065011400 HIGH motif; other site 271065011401 KMSKS motif; other site 271065011402 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 271065011403 anticodon binding site; other site 271065011404 tRNA binding surface [nucleotide binding]; other site 271065011405 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 271065011406 dimer interface [polypeptide binding]; other site 271065011407 putative tRNA-binding site [nucleotide binding]; other site 271065011408 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 271065011409 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 271065011410 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271065011411 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 271065011412 FtsX-like permease family; Region: FtsX; cl15850 271065011413 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 271065011414 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 271065011415 FtsX-like permease family; Region: FtsX; cl15850 271065011416 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 271065011417 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 271065011418 Walker A/P-loop; other site 271065011419 ATP binding site [chemical binding]; other site 271065011420 Q-loop/lid; other site 271065011421 ABC transporter signature motif; other site 271065011422 Walker B; other site 271065011423 D-loop; other site 271065011424 H-loop/switch region; other site 271065011425 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 271065011426 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 271065011427 substrate binding site [chemical binding]; other site 271065011428 ATP binding site [chemical binding]; other site 271065011429 Predicted solute binding protein [General function prediction only]; Region: COG3889 271065011430 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 271065011431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 271065011432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271065011433 dimer interface [polypeptide binding]; other site 271065011434 conserved gate region; other site 271065011435 putative PBP binding loops; other site 271065011436 ABC-ATPase subunit interface; other site 271065011437 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 271065011438 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 271065011439 Walker A/P-loop; other site 271065011440 ATP binding site [chemical binding]; other site 271065011441 Q-loop/lid; other site 271065011442 ABC transporter signature motif; other site 271065011443 Walker B; other site 271065011444 D-loop; other site 271065011445 H-loop/switch region; other site 271065011446 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 271065011447 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 271065011448 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 271065011449 Walker A/P-loop; other site 271065011450 ATP binding site [chemical binding]; other site 271065011451 Q-loop/lid; other site 271065011452 ABC transporter signature motif; other site 271065011453 Walker B; other site 271065011454 D-loop; other site 271065011455 H-loop/switch region; other site 271065011456 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 271065011457 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 271065011458 putative substrate binding pocket [chemical binding]; other site 271065011459 AC domain interface; other site 271065011460 catalytic triad [active] 271065011461 AB domain interface; other site 271065011462 interchain disulfide; other site 271065011463 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 271065011464 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 271065011465 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 271065011466 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 271065011467 putative catalytic residue [active] 271065011468 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 271065011469 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 271065011470 ligand binding site [chemical binding]; other site 271065011471 flexible hinge region; other site 271065011472 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 271065011473 putative switch regulator; other site 271065011474 non-specific DNA interactions [nucleotide binding]; other site 271065011475 DNA binding site [nucleotide binding] 271065011476 sequence specific DNA binding site [nucleotide binding]; other site 271065011477 putative cAMP binding site [chemical binding]; other site 271065011478 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271065011479 dimerization interface [polypeptide binding]; other site 271065011480 putative DNA binding site [nucleotide binding]; other site 271065011481 putative Zn2+ binding site [ion binding]; other site 271065011482 Oxygen tolerance; Region: BatD; pfam13584 271065011483 hypothetical protein; Provisional; Region: PRK13685 271065011484 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 271065011485 metal ion-dependent adhesion site (MIDAS); other site 271065011486 Tetratricopeptide repeat; Region: TPR_16; pfam13432 271065011487 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271065011488 TPR motif; other site 271065011489 binding surface 271065011490 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 271065011491 metal ion-dependent adhesion site (MIDAS); other site 271065011492 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 271065011493 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 271065011494 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 271065011495 MoxR-like ATPases [General function prediction only]; Region: COG0714 271065011496 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271065011497 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 271065011498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271065011499 putative substrate translocation pore; other site 271065011500 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 271065011501 short chain dehydrogenase; Validated; Region: PRK06182 271065011502 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 271065011503 NADP binding site [chemical binding]; other site 271065011504 active site 271065011505 steroid binding site; other site 271065011506 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 271065011507 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 271065011508 HNH endonuclease; Region: HNH_3; pfam13392 271065011509 DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor...; Region: AP2; cl00033 271065011510 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 271065011511 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cl00148 271065011512 primary dimer interface [polypeptide binding]; other site 271065011513 YcfA-like protein; Region: YcfA; cl00752 271065011514 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 271065011515 integrase; Provisional; Region: PRK09692 271065011516 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 271065011517 active site 271065011518 Int/Topo IB signature motif; other site 271065011519 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 271065011520 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 271065011521 trmE is a tRNA modification GTPase; Region: trmE; cd04164 271065011522 G1 box; other site 271065011523 GTP/Mg2+ binding site [chemical binding]; other site 271065011524 Switch I region; other site 271065011525 G2 box; other site 271065011526 Switch II region; other site 271065011527 G3 box; other site 271065011528 G4 box; other site 271065011529 G5 box; other site 271065011530 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 271065011531 membrane protein insertase; Provisional; Region: PRK01318 271065011532 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 271065011533 Ribonuclease P; Region: Ribonuclease_P; cl00457