-- dump date   	20120504_152648
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
449447000001	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
449447000002	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
449447000003	substrate binding pocket [chemical binding]; other site
449447000004	chain length determination region; other site
449447000005	substrate-Mg2+ binding site; other site
449447000006	catalytic residues [active]
449447000007	aspartate-rich region 1; other site
449447000008	active site lid residues [active]
449447000009	aspartate-rich region 2; other site
449447000010	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
449447000011	catalytic loop [active]
449447000012	iron binding site [ion binding]; other site
449447000013	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
449447000014	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
449447000015	active site
449447000016	catalytic residues [active]
449447000017	metal binding site [ion binding]; metal-binding site
449447000018	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
449447000019	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000020	binding surface
449447000021	TPR motif; other site
449447000022	TPR repeat; Region: TPR_11; pfam13414
449447000023	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000024	TPR repeat; Region: TPR_11; pfam13414
449447000025	binding surface
449447000026	TPR motif; other site
449447000027	Tetratricopeptide repeat; Region: TPR_16; pfam13432
449447000028	AIR carboxylase; Region: AIRC; cl00310
449447000029	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447000030	putative active site [active]
449447000031	H-NS histone family; Region: Histone_HNS; pfam00816
449447000032	acyl-CoA synthetase; Validated; Region: PRK05850
449447000033	AMP-binding enzyme; Region: AMP-binding; cl15778
449447000034	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
449447000035	active site
449447000036	YcfA-like protein; Region: YcfA; cl00752
449447000037	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
449447000038	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
449447000039	lipoprotein signal peptidase; Provisional; Region: PRK14787
449447000040	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942
449447000041	biotin synthase; Region: bioB; TIGR00433
449447000042	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447000043	FeS/SAM binding site; other site
449447000044	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
449447000045	Cupin domain; Region: Cupin_2; cl09118
449447000046	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
449447000047	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
449447000048	NADP binding site [chemical binding]; other site
449447000049	active site
449447000050	putative substrate binding site [chemical binding]; other site
449447000051	G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189
449447000052	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
449447000053	substrate binding site; other site
449447000054	metal-binding site
449447000055	Oligomer interface; other site
449447000056	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
449447000057	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
449447000058	tartrate dehydrogenase; Provisional; Region: PRK08194
449447000059	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
449447000060	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
449447000061	GIY-YIG motif/motif A; other site
449447000062	active site
449447000063	catalytic site [active]
449447000064	putative DNA binding site [nucleotide binding]; other site
449447000065	metal binding site [ion binding]; metal-binding site
449447000066	UvrB/uvrC motif; Region: UVR; pfam02151
449447000067	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
449447000068	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
449447000069	D1, D2 subunits of photosystem II  (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220
449447000070	Low molecular weight phosphatase family; Region: LMWPc; cd00115
449447000071	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
449447000072	active site
449447000073	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
449447000074	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447000075	active site
449447000076	phosphorylation site [posttranslational modification]
449447000077	intermolecular recognition site; other site
449447000078	dimerization interface [polypeptide binding]; other site
449447000079	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
449447000080	DNA binding residues [nucleotide binding]
449447000081	dimerization interface [polypeptide binding]; other site
449447000082	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
449447000083	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
449447000084	TM-ABC transporter signature motif; other site
449447000085	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
449447000086	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
449447000087	Walker A/P-loop; other site
449447000088	ATP binding site [chemical binding]; other site
449447000089	Q-loop/lid; other site
449447000090	ABC transporter signature motif; other site
449447000091	Walker B; other site
449447000092	D-loop; other site
449447000093	H-loop/switch region; other site
449447000094	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
449447000095	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
449447000096	putative active site [active]
449447000097	oxyanion strand; other site
449447000098	catalytic triad [active]
449447000099	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
449447000100	AAA domain; Region: AAA_21; pfam13304
449447000101	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447000102	putative active site [active]
449447000103	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447000104	putative active site [active]
449447000105	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447000106	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447000107	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
449447000108	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447000109	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447000110	YcfA-like protein; Region: YcfA; cl00752
449447000111	Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783
449447000112	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
449447000113	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
449447000114	active site
449447000115	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447000116	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447000117	putative active site [active]
449447000118	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447000119	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447000120	putative active site [active]
449447000121	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
449447000122	catalytic residues [active]
449447000123	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447000124	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447000125	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447000126	Peptidase S8 family domain in Thiazoline oxidase/subtilisin-like proteases; Region: Peptidases_S8_thiazoline_oxidase_subtilisin-like_p; cd07476
449447000127	putative active site [active]
449447000128	putative catalytic triad [active]
449447000129	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447000130	cyanobactin maturation protease, PatA/PatG family; Region: protease_PatA; TIGR03895
449447000131	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
449447000132	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
449447000133	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
449447000134	active site
449447000135	catalytic residues [active]
449447000136	cyanobactin maturation protease, PatA/PatG family; Region: protease_PatA; TIGR03895
449447000137	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
449447000138	catalytic residues [active]
449447000139	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
449447000140	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
449447000141	active site
449447000142	catalytic tetrad [active]
449447000143	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
449447000144	putative active site pocket [active]
449447000145	dimerization interface [polypeptide binding]; other site
449447000146	putative catalytic residue [active]
449447000147	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447000148	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447000149	Probable transposase; Region: OrfB_IS605; pfam01385
449447000150	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447000151	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
449447000152	DNA binding site [nucleotide binding]
449447000153	substrate interaction site [chemical binding]; other site
449447000154	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
449447000155	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
449447000156	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
449447000157	Integrase core domain; Region: rve; cl01316
449447000158	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
449447000159	non-specific DNA binding site [nucleotide binding]; other site
449447000160	salt bridge; other site
449447000161	sequence-specific DNA binding site [nucleotide binding]; other site
449447000162	GTP-binding protein Der; Reviewed; Region: PRK00093
449447000163	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
449447000164	G1 box; other site
449447000165	GTP/Mg2+ binding site [chemical binding]; other site
449447000166	Switch I region; other site
449447000167	G2 box; other site
449447000168	Switch II region; other site
449447000169	G3 box; other site
449447000170	G4 box; other site
449447000171	G5 box; other site
449447000172	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
449447000173	G1 box; other site
449447000174	GTP/Mg2+ binding site [chemical binding]; other site
449447000175	Switch I region; other site
449447000176	G2 box; other site
449447000177	G3 box; other site
449447000178	Switch II region; other site
449447000179	G4 box; other site
449447000180	G5 box; other site
449447000181	Cobalt transport protein; Region: CbiQ; cl00463
449447000182	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
449447000183	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
449447000184	Transposase; Region: DEDD_Tnp_IS110; pfam01548
449447000185	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
449447000186	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
449447000187	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
449447000188	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
449447000189	ATP binding site [chemical binding]; other site
449447000190	putative Mg++ binding site [ion binding]; other site
449447000191	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
449447000192	nucleotide binding region [chemical binding]; other site
449447000193	ATP-binding site [chemical binding]; other site
449447000194	RQC domain; Region: RQC; cl09632
449447000195	HRDC domain; Region: HRDC; cl02578
449447000196	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
449447000197	ATP synthase CF1 beta subunit; Region: atpB; CHL00060
449447000198	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
449447000199	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
449447000200	alpha subunit interaction interface [polypeptide binding]; other site
449447000201	Walker A motif; other site
449447000202	ATP binding site [chemical binding]; other site
449447000203	Walker B motif; other site
449447000204	inhibitor binding site; inhibition site
449447000205	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
449447000206	ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063
449447000207	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
449447000208	ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401
449447000209	Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65); Region: PSRP-3_Ycf65; cl04793
449447000210	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
449447000211	active site
449447000212	8-oxo-dGMP binding site [chemical binding]; other site
449447000213	nudix motif; other site
449447000214	metal binding site [ion binding]; metal-binding site
449447000215	Protein of unknown function (DUF3134); Region: DUF3134; pfam11332
449447000216	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
449447000217	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
449447000218	Mg++ binding site [ion binding]; other site
449447000219	putative catalytic motif [active]
449447000220	putative substrate binding site [chemical binding]; other site
449447000221	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
449447000222	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
449447000223	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
449447000224	Calx-beta domain; Region: Calx-beta; cl02522
449447000225	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519
449447000226	active site flap/lid [active]
449447000227	nucleophilic elbow; other site
449447000228	catalytic triad [active]
449447000229	Calx-beta domain; Region: Calx-beta; cl02522
449447000230	Calx-beta domain; Region: Calx-beta; cl02522
449447000231	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
449447000232	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
449447000233	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
449447000234	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
449447000235	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
449447000236	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
449447000237	Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085
449447000238	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
449447000239	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
449447000240	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
449447000241	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
449447000242	putative dimer interface [polypeptide binding]; other site
449447000243	[2Fe-2S] cluster binding site [ion binding]; other site
449447000244	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
449447000245	dimer interface [polypeptide binding]; other site
449447000246	[2Fe-2S] cluster binding site [ion binding]; other site
449447000247	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
449447000248	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
449447000249	SLBB domain; Region: SLBB; pfam10531
449447000250	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
449447000251	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447000252	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447000253	Probable transposase; Region: OrfB_IS605; pfam01385
449447000254	Transposase IS200 like; Region: Y1_Tnp; cl00848
449447000255	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
449447000256	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
449447000257	phosphate binding site [ion binding]; other site
449447000258	putative substrate binding pocket [chemical binding]; other site
449447000259	dimer interface [polypeptide binding]; other site
449447000260	Protein of unknown function (DUF3134); Region: DUF3134; pfam11332
449447000261	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
449447000262	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
449447000263	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
449447000264	active site
449447000265	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
449447000266	dimer interface [polypeptide binding]; other site
449447000267	substrate binding site [chemical binding]; other site
449447000268	catalytic residue [active]
449447000269	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
449447000270	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
449447000271	Walker A/P-loop; other site
449447000272	ATP binding site [chemical binding]; other site
449447000273	Q-loop/lid; other site
449447000274	ABC transporter signature motif; other site
449447000275	Walker B; other site
449447000276	D-loop; other site
449447000277	H-loop/switch region; other site
449447000278	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
449447000279	active site
449447000280	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
449447000281	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
449447000282	active site
449447000283	HIGH motif; other site
449447000284	dimer interface [polypeptide binding]; other site
449447000285	KMSKS motif; other site
449447000286	Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941
449447000287	Protein of unknown function (DUF422); Region: DUF422; cl00991
449447000288	hydrolase, alpha/beta fold family protein; Region: PLN02824
449447000289	Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
449447000290	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447000291	Walker A/P-loop; other site
449447000292	ATP binding site [chemical binding]; other site
449447000293	Q-loop/lid; other site
449447000294	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447000295	ABC transporter signature motif; other site
449447000296	Walker B; other site
449447000297	D-loop; other site
449447000298	H-loop/switch region; other site
449447000299	polyphosphate kinase; Provisional; Region: PRK05443
449447000300	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
449447000301	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
449447000302	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
449447000303	putative domain interface [polypeptide binding]; other site
449447000304	putative active site [active]
449447000305	catalytic site [active]
449447000306	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
449447000307	putative domain interface [polypeptide binding]; other site
449447000308	putative active site [active]
449447000309	catalytic site [active]
449447000310	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
449447000311	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
449447000312	Flavin Reductases; Region: FlaRed; cl00801
449447000313	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447000314	putative active site [active]
449447000315	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447000316	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
449447000317	Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783
449447000318	Helix-turn-helix domains; Region: HTH; cl00088
449447000319	Winged helix-turn helix; Region: HTH_29; pfam13551
449447000320	Helix-turn-helix domains; Region: HTH; cl00088
449447000321	Winged helix-turn helix; Region: HTH_33; pfam13592
449447000322	Integrase core domain; Region: rve; cl01316
449447000323	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
449447000324	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447000325	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
449447000326	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447000327	Winged helix-turn helix; Region: HTH_29; pfam13551
449447000328	Helix-turn-helix domains; Region: HTH; cl00088
449447000329	Helix-turn-helix domains; Region: HTH; cl00088
449447000330	Helix-turn-helix domains; Region: HTH; cl00088
449447000331	DNA binding site [nucleotide binding]
449447000332	Winged helix-turn helix; Region: HTH_29; pfam13551
449447000333	Helix-turn-helix domains; Region: HTH; cl00088
449447000334	Integrase core domain; Region: rve; cl01316
449447000335	Integrase core domain; Region: rve; cl01316
449447000336	Protein of unknown function (DUF2589); Region: DUF2589; pfam11655
449447000337	Beta/Gamma crystallin; Region: Crystall; cl02528
449447000338	Beta/Gamma crystallin; Region: Crystall; cl02528
449447000339	Protein of unknown function (DUF2589); Region: DUF2589; pfam11655
449447000340	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447000341	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447000342	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447000343	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447000344	PemK-like protein; Region: PemK; cl00995
449447000345	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447000346	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447000347	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
449447000348	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
449447000349	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447000350	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447000351	integral membrane protein MviN; Region: mviN; TIGR01695
449447000352	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
449447000353	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
449447000354	dimer interface [polypeptide binding]; other site
449447000355	motif 1; other site
449447000356	active site
449447000357	motif 2; other site
449447000358	motif 3; other site
449447000359	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
449447000360	anticodon binding site; other site
449447000361	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
449447000362	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
449447000363	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
449447000364	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447000365	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447000366	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447000367	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447000368	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000369	TPR repeat; Region: TPR_11; pfam13414
449447000370	binding surface
449447000371	TPR motif; other site
449447000372	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000373	binding surface
449447000374	TPR repeat; Region: TPR_11; pfam13414
449447000375	TPR motif; other site
449447000376	TPR repeat; Region: TPR_11; pfam13414
449447000377	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000378	binding surface
449447000379	TPR repeat; Region: TPR_11; pfam13414
449447000380	TPR motif; other site
449447000381	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000382	binding surface
449447000383	TPR repeat; Region: TPR_11; pfam13414
449447000384	TPR motif; other site
449447000385	TPR repeat; Region: TPR_11; pfam13414
449447000386	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000387	binding surface
449447000388	TPR repeat; Region: TPR_11; pfam13414
449447000389	TPR motif; other site
449447000390	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000391	binding surface
449447000392	TPR repeat; Region: TPR_11; pfam13414
449447000393	TPR motif; other site
449447000394	TPR repeat; Region: TPR_11; pfam13414
449447000395	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000396	TPR repeat; Region: TPR_11; pfam13414
449447000397	binding surface
449447000398	TPR motif; other site
449447000399	Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085
449447000400	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
449447000401	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
449447000402	NAD binding site [chemical binding]; other site
449447000403	homotetramer interface [polypeptide binding]; other site
449447000404	homodimer interface [polypeptide binding]; other site
449447000405	substrate binding site [chemical binding]; other site
449447000406	active site
449447000407	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
449447000408	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
449447000409	ligand binding site [chemical binding]; other site
449447000410	flexible hinge region; other site
449447000411	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
449447000412	putative switch regulator; other site
449447000413	non-specific DNA interactions [nucleotide binding]; other site
449447000414	DNA binding site [nucleotide binding]
449447000415	sequence specific DNA binding site [nucleotide binding]; other site
449447000416	putative cAMP binding site [chemical binding]; other site
449447000417	Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372
449447000418	Protein of unknown function (DUF3084); Region: DUF3084; pfam11283
449447000419	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447000420	putative active site [active]
449447000421	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447000422	putative active site [active]
449447000423	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
449447000424	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447000425	Protein kinase domain; Region: Pkinase; pfam00069
449447000426	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447000427	active site
449447000428	ATP binding site [chemical binding]; other site
449447000429	substrate binding site [chemical binding]; other site
449447000430	activation loop (A-loop); other site
449447000431	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
449447000432	Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909
449447000433	active site
449447000434	Zn binding site [ion binding]; other site
449447000435	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
449447000436	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
449447000437	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447000438	Walker A motif; other site
449447000439	ATP binding site [chemical binding]; other site
449447000440	Walker B motif; other site
449447000441	arginine finger; other site
449447000442	Peptidase family M41; Region: Peptidase_M41; pfam01434
449447000443	NIL domain; Region: NIL; cl09633
449447000444	4Fe-4S binding domain; Region: Fer4; cl02805
449447000445	hypothetical protein; Provisional; Region: PRK13795
449447000446	chorismate binding enzyme; Region: Chorismate_bind; cl10555
449447000447	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
449447000448	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
449447000449	NAD(P) binding site [chemical binding]; other site
449447000450	catalytic residues [active]
449447000451	Bacterial Ig-like domain; Region: Big_5; cl01012
449447000452	Domain of unknown function (DUF1980); Region: DUF1980; cl01492
449447000453	Predicted permease; Region: DUF318; pfam03773
449447000454	Predicted permeases [General function prediction only]; Region: COG0701
449447000455	TIGR00268 family protein; Region: TIGR00268
449447000456	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
449447000457	Ligand Binding Site [chemical binding]; other site
449447000458	Protein of unknown function (DUF433); Region: DUF433; cl01030
449447000459	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
449447000460	XisI protein; Region: XisI; pfam08869
449447000461	XisH protein; Region: XisH; pfam08814
449447000462	Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137
449447000463	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
449447000464	ANP binding site [chemical binding]; other site
449447000465	Substrate Binding Site II [chemical binding]; other site
449447000466	Substrate Binding Site I [chemical binding]; other site
449447000467	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731
449447000468	GAF domain; Region: GAF; cl15785
449447000469	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
449447000470	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447000471	dimer interface [polypeptide binding]; other site
449447000472	phosphorylation site [posttranslational modification]
449447000473	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447000474	ATP binding site [chemical binding]; other site
449447000475	Mg2+ binding site [ion binding]; other site
449447000476	G-X-G motif; other site
449447000477	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
449447000478	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
449447000479	ATP-grasp domain; Region: ATP-grasp_4; cl03087
449447000480	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447000481	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
449447000482	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447000483	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
449447000484	Methyltransferase domain; Region: Methyltransf_31; pfam13847
449447000485	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447000486	S-adenosylmethionine binding site [chemical binding]; other site
449447000487	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
449447000488	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
449447000489	TM-ABC transporter signature motif; other site
449447000490	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
449447000491	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088
449447000492	Sulfate transporter family; Region: Sulfate_transp; cl15842
449447000493	high affinity sulphate transporter 1; Region: sulP; TIGR00815
449447000494	Sulfate transporter family; Region: Sulfate_transp; cl15842
449447000495	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
449447000496	Transposase IS200 like; Region: Y1_Tnp; cl00848
449447000497	Transposase; Region: DEDD_Tnp_IS110; pfam01548
449447000498	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
449447000499	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447000500	Probable transposase; Region: OrfB_IS605; pfam01385
449447000501	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447000502	Ion channel; Region: Ion_trans_2; cl11596
449447000503	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
449447000504	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
449447000505	SNF2 Helicase protein; Region: DUF3670; pfam12419
449447000506	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
449447000507	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
449447000508	ATP binding site [chemical binding]; other site
449447000509	putative Mg++ binding site [ion binding]; other site
449447000510	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
449447000511	nucleotide binding region [chemical binding]; other site
449447000512	ATP-binding site [chemical binding]; other site
449447000513	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447000514	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
449447000515	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447000516	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447000517	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000518	binding surface
449447000519	TPR motif; other site
449447000520	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
449447000521	dimerization interface [polypeptide binding]; other site
449447000522	putative DNA binding site [nucleotide binding]; other site
449447000523	putative Zn2+ binding site [ion binding]; other site
449447000524	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447000525	putative active site [active]
449447000526	PemK-like protein; Region: PemK; cl00995
449447000527	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
449447000528	recombination protein F; Reviewed; Region: recF; PRK00064
449447000529	RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage.  When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242
449447000530	Walker A/P-loop; other site
449447000531	ATP binding site [chemical binding]; other site
449447000532	Q-loop/lid; other site
449447000533	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447000534	ABC transporter signature motif; other site
449447000535	Walker B; other site
449447000536	D-loop; other site
449447000537	H-loop/switch region; other site
449447000538	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
449447000539	tetramer (dimer of dimers) interface [polypeptide binding]; other site
449447000540	active site
449447000541	dimer interface [polypeptide binding]; other site
449447000542	RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590
449447000543	RNA/DNA binding site [nucleotide binding]; other site
449447000544	RRM dimerization site [polypeptide binding]; other site
449447000545	Phycobilisome degradation protein nblA; Region: NblA; pfam04485
449447000546	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
449447000547	Ligand Binding Site [chemical binding]; other site
449447000548	Low molecular weight phosphatase family; Region: LMWPc; cd00115
449447000549	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
449447000550	active site
449447000551	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
449447000552	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
449447000553	Membrane transport protein; Region: Mem_trans; cl09117
449447000554	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
449447000555	dimerization interface [polypeptide binding]; other site
449447000556	putative DNA binding site [nucleotide binding]; other site
449447000557	putative Zn2+ binding site [ion binding]; other site
449447000558	Photosystem II complex subunit Ycf12; Region: PSII_Ycf12; cl12139
449447000559	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
449447000560	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
449447000561	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
449447000562	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
449447000563	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
449447000564	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
449447000565	Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085
449447000566	phosphoenolpyruvate synthase; Validated; Region: PRK06464
449447000567	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
449447000568	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
449447000569	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
449447000570	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
449447000571	GUN4-like; Region: GUN4; pfam05419
449447000572	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
449447000573	putative active site [active]
449447000574	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447000575	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447000576	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
449447000577	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
449447000578	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09567
449447000579	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
449447000580	Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913
449447000581	Precorrin-8X methylmutase; Region: CbiC; pfam02570
449447000582	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
449447000583	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
449447000584	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
449447000585	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
449447000586	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
449447000587	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
449447000588	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
449447000589	catalytic residues [active]
449447000590	Acetokinase family; Region: Acetate_kinase; cl01029
449447000591	propionate/acetate kinase; Provisional; Region: PRK12379
449447000592	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
449447000593	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
449447000594	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
449447000595	DNA binding residues [nucleotide binding]
449447000596	PAP_fibrillin; Region: PAP_fibrillin; pfam04755
449447000597	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
449447000598	active site
449447000599	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
449447000600	protein binding site [polypeptide binding]; other site
449447000601	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
449447000602	putative substrate binding region [chemical binding]; other site
449447000603	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
449447000604	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
449447000605	minor groove reading motif; other site
449447000606	helix-hairpin-helix signature motif; other site
449447000607	substrate binding pocket [chemical binding]; other site
449447000608	active site
449447000609	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
449447000610	Rhomboid family; Region: Rhomboid; cl11446
449447000611	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
449447000612	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
449447000613	homooctamer interface [polypeptide binding]; other site
449447000614	active site
449447000615	Helix-turn-helix domains; Region: HTH; cl00088
449447000616	Winged helix-turn helix; Region: HTH_29; pfam13551
449447000617	Winged helix-turn helix; Region: HTH_33; pfam13592
449447000618	Integrase core domain; Region: rve; cl01316
449447000619	Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066
449447000620	nickel binding site [ion binding]; other site
449447000621	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447000622	putative active site [active]
449447000623	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447000624	putative active site [active]
449447000625	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
449447000626	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
449447000627	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
449447000628	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
449447000629	muropeptide transporter; Validated; Region: ampG; PRK11010
449447000630	AmpG-related permease; Region: 2A0125; TIGR00901
449447000631	GAF domain; Region: GAF; cl15785
449447000632	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
449447000633	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
449447000634	Probable transposase; Region: OrfB_IS605; pfam01385
449447000635	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447000636	Probable transposase; Region: OrfB_IS605; pfam01385
449447000637	NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370
449447000638	dimer interface [polypeptide binding]; other site
449447000639	FMN binding site [chemical binding]; other site
449447000640	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
449447000641	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
449447000642	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
449447000643	DNA binding residues [nucleotide binding]
449447000644	dimer interface [polypeptide binding]; other site
449447000645	CpeS-like protein; Region: CpeS; pfam09367
449447000646	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
449447000647	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
449447000648	Ligand binding site; other site
449447000649	Putative Catalytic site; other site
449447000650	DXD motif; other site
449447000651	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
449447000652	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
449447000653	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
449447000654	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
449447000655	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
449447000656	NADP-binding site; other site
449447000657	homotetramer interface [polypeptide binding]; other site
449447000658	substrate binding site [chemical binding]; other site
449447000659	homodimer interface [polypeptide binding]; other site
449447000660	active site
449447000661	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
449447000662	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
449447000663	active site
449447000664	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
449447000665	Mechanosensitive ion channel; Region: MS_channel; pfam00924
449447000666	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
449447000667	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447000668	NAD(P) binding site [chemical binding]; other site
449447000669	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
449447000670	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
449447000671	active site
449447000672	metal binding site [ion binding]; metal-binding site
449447000673	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
449447000674	Poxvirus A12 protein; Region: Pox_A12; pfam04651
449447000675	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
449447000676	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
449447000677	putative peptidoglycan binding site; other site
449447000678	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
449447000679	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447000680	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447000681	Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335
449447000682	Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776
449447000683	Helix-turn-helix domains; Region: HTH; cl00088
449447000684	Winged helix-turn helix; Region: HTH_29; pfam13551
449447000685	Winged helix-turn helix; Region: HTH_33; pfam13592
449447000686	Integrase core domain; Region: rve; cl01316
449447000687	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447000688	Probable transposase; Region: OrfB_IS605; pfam01385
449447000689	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447000690	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
449447000691	SNF2 Helicase protein; Region: DUF3670; pfam12419
449447000692	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
449447000693	ATP binding site [chemical binding]; other site
449447000694	putative Mg++ binding site [ion binding]; other site
449447000695	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
449447000696	nucleotide binding region [chemical binding]; other site
449447000697	ATP-binding site [chemical binding]; other site
449447000698	SWIM zinc finger; Region: SWIM; cl15408
449447000699	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447000700	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
449447000701	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447000702	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
449447000703	Septation ring formation regulator, EzrA; Region: EzrA; pfam06160
449447000704	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
449447000705	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
449447000706	ring oligomerisation interface [polypeptide binding]; other site
449447000707	ATP/Mg binding site [chemical binding]; other site
449447000708	stacking interactions; other site
449447000709	hinge regions; other site
449447000710	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
449447000711	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447000712	Walker A/P-loop; other site
449447000713	ATP binding site [chemical binding]; other site
449447000714	Q-loop/lid; other site
449447000715	ABC transporter signature motif; other site
449447000716	Walker B; other site
449447000717	D-loop; other site
449447000718	H-loop/switch region; other site
449447000719	ABC transporter; Region: ABC_tran_2; pfam12848
449447000720	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
449447000721	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
449447000722	Calx-beta domain; Region: Calx-beta; cl02522
449447000723	Calx-beta domain; Region: Calx-beta; cl02522
449447000724	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
449447000725	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
449447000726	putative active site [active]
449447000727	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
449447000728	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
449447000729	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
449447000730	HSP70 interaction site [polypeptide binding]; other site
449447000731	Protein of unknown function (DUF3611); Region: DUF3611; pfam12263
449447000732	Protein of unknown function (DUF565); Region: DUF565; pfam04483
449447000733	TPR repeat; Region: TPR_11; pfam13414
449447000734	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000735	binding surface
449447000736	TPR motif; other site
449447000737	TPR repeat; Region: TPR_11; pfam13414
449447000738	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000739	binding surface
449447000740	TPR motif; other site
449447000741	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000742	binding surface
449447000743	TPR motif; other site
449447000744	TPR repeat; Region: TPR_11; pfam13414
449447000745	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000746	binding surface
449447000747	TPR motif; other site
449447000748	TPR repeat; Region: TPR_11; pfam13414
449447000749	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447000750	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
449447000751	Protein of unknown function (Ytp1); Region: Ytp1; pfam10355
449447000752	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
449447000753	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
449447000754	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000755	TPR repeat; Region: TPR_11; pfam13414
449447000756	binding surface
449447000757	TPR motif; other site
449447000758	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
449447000759	binding surface
449447000760	TPR motif; other site
449447000761	TPR repeat; Region: TPR_11; pfam13414
449447000762	TPR repeat; Region: TPR_11; pfam13414
449447000763	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000764	binding surface
449447000765	TPR motif; other site
449447000766	TPR repeat; Region: TPR_11; pfam13414
449447000767	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000768	binding surface
449447000769	TPR motif; other site
449447000770	TPR repeat; Region: TPR_11; pfam13414
449447000771	TPR repeat; Region: TPR_11; pfam13414
449447000772	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
449447000773	TPR repeat; Region: TPR_11; pfam13414
449447000774	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000775	binding surface
449447000776	TPR motif; other site
449447000777	TPR repeat; Region: TPR_11; pfam13414
449447000778	TPR repeat; Region: TPR_11; pfam13414
449447000779	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000780	binding surface
449447000781	TPR motif; other site
449447000782	TPR repeat; Region: TPR_11; pfam13414
449447000783	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000784	binding surface
449447000785	TPR motif; other site
449447000786	TPR repeat; Region: TPR_11; pfam13414
449447000787	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000788	binding surface
449447000789	TPR motif; other site
449447000790	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
449447000791	TPR repeat; Region: TPR_11; pfam13414
449447000792	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000793	binding surface
449447000794	TPR motif; other site
449447000795	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447000796	putative active site [active]
449447000797	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
449447000798	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
449447000799	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447000800	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447000801	Transposase [DNA replication, recombination, and repair]; Region: COG5433
449447000802	Protein of unknown function DUF86; Region: DUF86; cl01031
449447000803	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
449447000804	active site
449447000805	NTP binding site [chemical binding]; other site
449447000806	metal binding triad [ion binding]; metal-binding site
449447000807	antibiotic binding site [chemical binding]; other site
449447000808	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
449447000809	YcfA-like protein; Region: YcfA; cl00752
449447000810	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
449447000811	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
449447000812	TPR repeat; Region: TPR_11; pfam13414
449447000813	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000814	TPR motif; other site
449447000815	binding surface
449447000816	TPR repeat; Region: TPR_11; pfam13414
449447000817	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000818	binding surface
449447000819	TPR motif; other site
449447000820	TPR repeat; Region: TPR_11; pfam13414
449447000821	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000822	binding surface
449447000823	TPR motif; other site
449447000824	TPR repeat; Region: TPR_11; pfam13414
449447000825	TPR repeat; Region: TPR_11; pfam13414
449447000826	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
449447000827	TPR repeat; Region: TPR_11; pfam13414
449447000828	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000829	binding surface
449447000830	TPR motif; other site
449447000831	TPR repeat; Region: TPR_11; pfam13414
449447000832	TPR repeat; Region: TPR_11; pfam13414
449447000833	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000834	binding surface
449447000835	TPR motif; other site
449447000836	TPR repeat; Region: TPR_11; pfam13414
449447000837	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000838	binding surface
449447000839	TPR motif; other site
449447000840	TPR repeat; Region: TPR_11; pfam13414
449447000841	TPR repeat; Region: TPR_11; pfam13414
449447000842	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
449447000843	TPR repeat; Region: TPR_11; pfam13414
449447000844	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000845	binding surface
449447000846	TPR motif; other site
449447000847	TPR repeat; Region: TPR_11; pfam13414
449447000848	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000849	binding surface
449447000850	TPR motif; other site
449447000851	Tetratricopeptide repeat; Region: TPR_16; pfam13432
449447000852	CHAT domain; Region: CHAT; pfam12770
449447000853	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
449447000854	CHASE2 domain; Region: CHASE2; cl01732
449447000855	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
449447000856	FtsH Extracellular; Region: FtsH_ext; pfam06480
449447000857	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
449447000858	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447000859	Walker A motif; other site
449447000860	ATP binding site [chemical binding]; other site
449447000861	Walker B motif; other site
449447000862	arginine finger; other site
449447000863	Peptidase family M41; Region: Peptidase_M41; pfam01434
449447000864	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447000865	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
449447000866	Predicted membrane protein [Function unknown]; Region: COG3463
449447000867	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
449447000868	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
449447000869	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
449447000870	substrate binding pocket [chemical binding]; other site
449447000871	membrane-bound complex binding site; other site
449447000872	hinge residues; other site
449447000873	Domain of unknown function DUF20; Region: UPF0118; pfam01594
449447000874	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
449447000875	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
449447000876	HSP70 interaction site [polypeptide binding]; other site
449447000877	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447000878	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447000879	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
449447000880	Magnesium ion binding site [ion binding]; other site
449447000881	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
449447000882	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
449447000883	GatB domain; Region: GatB_Yqey; cl11497
449447000884	pyruvate kinase; Validated; Region: PRK08187
449447000885	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
449447000886	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
449447000887	domain interfaces; other site
449447000888	active site
449447000889	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447000890	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
449447000891	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
449447000892	G-X-X-G motif; other site
449447000893	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
449447000894	RxxxH motif; other site
449447000895	putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654
449447000896	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
449447000897	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
449447000898	Bacterial PH domain; Region: DUF304; cl01348
449447000899	Ribonuclease P; Region: Ribonuclease_P; cl00457
449447000900	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
449447000901	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
449447000902	glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561
449447000903	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801
449447000904	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
449447000905	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
449447000906	motif II; other site
449447000907	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
449447000908	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
449447000909	dimer interface [polypeptide binding]; other site
449447000910	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
449447000911	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
449447000912	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
449447000913	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
449447000914	Walker A motif; other site
449447000915	ATP binding site [chemical binding]; other site
449447000916	Walker B motif; other site
449447000917	pilus retraction protein PilT; Region: pilT_fam; TIGR01420
449447000918	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
449447000919	Walker A motif; other site
449447000920	ATP binding site [chemical binding]; other site
449447000921	Walker B motif; other site
449447000922	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
449447000923	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
449447000924	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
449447000925	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
449447000926	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447000927	FeS/SAM binding site; other site
449447000928	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
449447000929	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090
449447000930	Helix-turn-helix domains; Region: HTH; cl00088
449447000931	Winged helix-turn helix; Region: HTH_29; pfam13551
449447000932	Helix-turn-helix domains; Region: HTH; cl00088
449447000933	Integrase core domain; Region: rve; cl01316
449447000934	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
449447000935	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
449447000936	Protein of unknown function (DUF3680); Region: DUF3680; cl02189
449447000937	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
449447000938	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
449447000939	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
449447000940	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
449447000941	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447000942	Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085
449447000943	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
449447000944	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
449447000945	Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085
449447000946	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
449447000947	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
449447000948	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
449447000949	Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085
449447000950	Integrase core domain; Region: rve; cl01316
449447000951	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447000952	Helix-turn-helix domains; Region: HTH; cl00088
449447000953	DNA binding site [nucleotide binding]
449447000954	Winged helix-turn helix; Region: HTH_29; pfam13551
449447000955	Helix-turn-helix domains; Region: HTH; cl00088
449447000956	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
449447000957	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
449447000958	putative dimer interface [polypeptide binding]; other site
449447000959	putative anticodon binding site; other site
449447000960	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
449447000961	homodimer interface [polypeptide binding]; other site
449447000962	motif 1; other site
449447000963	motif 2; other site
449447000964	active site
449447000965	motif 3; other site
449447000966	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447000967	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447000968	Probable transposase; Region: OrfB_IS605; pfam01385
449447000969	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447000970	TM2 domain; Region: TM2; cl00984
449447000971	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
449447000972	DNA gyrase subunit A; Validated; Region: PRK05560
449447000973	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
449447000974	CAP-like domain; other site
449447000975	active site
449447000976	primary dimer interface [polypeptide binding]; other site
449447000977	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
449447000978	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
449447000979	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
449447000980	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
449447000981	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
449447000982	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
449447000983	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
449447000984	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
449447000985	cofactor binding site; other site
449447000986	DNA binding site [nucleotide binding]
449447000987	substrate interaction site [chemical binding]; other site
449447000988	ICEA Protein; Region: ICEA; pfam05315
449447000989	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
449447000990	non-specific DNA binding site [nucleotide binding]; other site
449447000991	salt bridge; other site
449447000992	sequence-specific DNA binding site [nucleotide binding]; other site
449447000993	UreD urease accessory protein; Region: UreD; cl00530
449447000994	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534
449447000995	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
449447000996	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447000997	S-adenosylmethionine binding site [chemical binding]; other site
449447000998	CrcB-like protein; Region: CRCB; cl09114
449447000999	CrcB-like protein; Region: CRCB; cl09114
449447001000	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
449447001001	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447001002	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
449447001003	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
449447001004	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
449447001005	Protein of unknown function (DUF3370); Region: DUF3370; pfam11850
449447001006	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
449447001007	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447001008	FeS/SAM binding site; other site
449447001009	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
449447001010	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
449447001011	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447001012	putative active site [active]
449447001013	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447001014	putative active site [active]
449447001015	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
449447001016	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
449447001017	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
449447001018	P loop; other site
449447001019	GTP binding site [chemical binding]; other site
449447001020	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
449447001021	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235
449447001022	Protein of unknown function (DUF3119); Region: DUF3119; pfam11317
449447001023	TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325
449447001024	Protein of unknown function (DUF3086); Region: DUF3086; pfam11285
449447001025	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447001026	putative active site [active]
449447001027	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447001028	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447001029	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447001030	Cyd operon protein YbgE (Cyd_oper_YbgE); Region: Cyd_oper_YbgE; cl11451
449447001031	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447001032	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
449447001033	Helix-turn-helix domains; Region: HTH; cl00088
449447001034	Helix-turn-helix domains; Region: HTH; cl00088
449447001035	Integrase core domain; Region: rve; cl01316
449447001036	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447001037	Transposase domain (DUF772); Region: DUF772; cl15789
449447001038	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
449447001039	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447001040	putative active site [active]
449447001041	Domain of unknown function (DUF927); Region: DUF927; cl12098
449447001042	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
449447001043	catalytic core [active]
449447001044	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
449447001045	DHH family; Region: DHH; pfam01368
449447001046	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447001047	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447001048	Uncharacterized protein family (UPF0257); Region: UPF0257; cl14672
449447001049	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447001050	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447001051	HsdM N-terminal domain; Region: HsdM_N; pfam12161
449447001052	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447001053	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
449447001054	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
449447001055	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
449447001056	putative active site [active]
449447001057	EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737
449447001058	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
449447001059	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
449447001060	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
449447001061	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447001062	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447001063	Integrase core domain; Region: rve; cl01316
449447001064	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
449447001065	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
449447001066	Helix-turn-helix domains; Region: HTH; cl00088
449447001067	Winged helix-turn helix; Region: HTH_29; pfam13551
449447001068	Winged helix-turn helix; Region: HTH_33; pfam13592
449447001069	Integrase core domain; Region: rve; cl01316
449447001070	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
449447001071	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447001072	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447001073	putative active site [active]
449447001074	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447001075	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447001076	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447001077	putative active site [active]
449447001078	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447001079	putative active site [active]
449447001080	citrate synthase; Provisional; Region: PRK14036
449447001081	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
449447001082	oxalacetate binding site [chemical binding]; other site
449447001083	citrylCoA binding site [chemical binding]; other site
449447001084	coenzyme A binding site [chemical binding]; other site
449447001085	catalytic triad [active]
449447001086	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
449447001087	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
449447001088	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
449447001089	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
449447001090	active site
449447001091	TDP-binding site; other site
449447001092	acceptor substrate-binding pocket; other site
449447001093	homodimer interface [polypeptide binding]; other site
449447001094	Protein of unknown function (DUF433); Region: DUF433; cl01030
449447001095	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447001096	Probable transposase; Region: OrfB_IS605; pfam01385
449447001097	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447001098	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
449447001099	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
449447001100	NAD binding site [chemical binding]; other site
449447001101	dimer interface [polypeptide binding]; other site
449447001102	substrate binding site [chemical binding]; other site
449447001103	tetramer (dimer of dimers) interface [polypeptide binding]; other site
449447001104	Protein of unknown function (DUF952); Region: DUF952; cl01393
449447001105	cytosine deaminase-like protein; Validated; Region: PRK07583
449447001106	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
449447001107	active site
449447001108	FO synthase subunit 1; Reviewed; Region: cofG; PRK06245
449447001109	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447001110	FeS/SAM binding site; other site
449447001111	FOG: WD40-like repeat [Function unknown]; Region: COG1520
449447001112	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
449447001113	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
449447001114	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912
449447001115	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
449447001116	putative active site [active]
449447001117	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
449447001118	putative active site [active]
449447001119	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
449447001120	catalytic center binding site [active]
449447001121	ATP binding site [chemical binding]; other site
449447001122	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
449447001123	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
449447001124	G1 box; other site
449447001125	GTP/Mg2+ binding site [chemical binding]; other site
449447001126	Switch I region; other site
449447001127	G2 box; other site
449447001128	Switch II region; other site
449447001129	G3 box; other site
449447001130	G4 box; other site
449447001131	G5 box; other site
449447001132	Domain of unknown function (DUF697); Region: DUF697; cl12064
449447001133	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
449447001134	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
449447001135	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
449447001136	Predicted ATPases [General function prediction only]; Region: COG1106
449447001137	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447001138	Walker A/P-loop; other site
449447001139	ATP binding site [chemical binding]; other site
449447001140	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
449447001141	L-asparaginase II; Region: Asparaginase_II; cl01842
449447001142	Protein of unknown function (DUF1230); Region: DUF1230; pfam06799
449447001143	Oligomerisation domain; Region: Oligomerisation; cl00519
449447001144	Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713
449447001145	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
449447001146	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
449447001147	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
449447001148	G1 box; other site
449447001149	GTP/Mg2+ binding site [chemical binding]; other site
449447001150	Switch I region; other site
449447001151	G2 box; other site
449447001152	Switch II region; other site
449447001153	G3 box; other site
449447001154	G4 box; other site
449447001155	G5 box; other site
449447001156	Domain of unknown function (DUF697); Region: DUF697; cl12064
449447001157	Probable transposase; Region: OrfB_IS605; pfam01385
449447001158	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447001159	pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144
449447001160	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
449447001161	alpha subunit interface [polypeptide binding]; other site
449447001162	TPP binding site [chemical binding]; other site
449447001163	heterodimer interface [polypeptide binding]; other site
449447001164	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
449447001165	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
449447001166	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
449447001167	Protein export membrane protein; Region: SecD_SecF; cl14618
449447001168	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
449447001169	Protein export membrane protein; Region: SecD_SecF; cl14618
449447001170	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
449447001171	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447001172	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447001173	Protein of unknown function (DUF497); Region: DUF497; cl01108
449447001174	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
449447001175	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
449447001176	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
449447001177	putative active site [active]
449447001178	putative NTP binding site [chemical binding]; other site
449447001179	putative nucleic acid binding site [nucleotide binding]; other site
449447001180	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
449447001181	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
449447001182	active site
449447001183	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
449447001184	active site
449447001185	putative DNA-binding cleft [nucleotide binding]; other site
449447001186	dimer interface [polypeptide binding]; other site
449447001187	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
449447001188	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
449447001189	active site
449447001190	homodimer interface [polypeptide binding]; other site
449447001191	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
449447001192	mce related protein; Region: MCE; pfam02470
449447001193	Substrate binding subunit of ER-derived-lipid transporter; Provisional; Region: PLN03094
449447001194	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
449447001195	ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261
449447001196	Walker A/P-loop; other site
449447001197	ATP binding site [chemical binding]; other site
449447001198	Q-loop/lid; other site
449447001199	ABC transporter signature motif; other site
449447001200	Walker B; other site
449447001201	D-loop; other site
449447001202	H-loop/switch region; other site
449447001203	C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733
449447001204	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447001205	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
449447001206	catalytic core [active]
449447001207	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
449447001208	catalytic core [active]
449447001209	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
449447001210	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
449447001211	acetolactate synthase; Reviewed; Region: PRK08322
449447001212	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
449447001213	PYR/PP interface [polypeptide binding]; other site
449447001214	dimer interface [polypeptide binding]; other site
449447001215	TPP binding site [chemical binding]; other site
449447001216	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
449447001217	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
449447001218	TPP-binding site [chemical binding]; other site
449447001219	dimer interface [polypeptide binding]; other site
449447001220	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447001221	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
449447001222	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
449447001223	Probable Catalytic site; other site
449447001224	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447001225	S-layer homology domain; Region: SLH; pfam00395
449447001226	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
449447001227	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
449447001228	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447001229	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
449447001230	catalytic triad [active]
449447001231	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447001232	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447001233	Winged helix-turn helix; Region: HTH_29; pfam13551
449447001234	Helix-turn-helix domains; Region: HTH; cl00088
449447001235	Helix-turn-helix domains; Region: HTH; cl00088
449447001236	Integrase core domain; Region: rve; cl01316
449447001237	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
449447001238	active site
449447001239	substrate-binding site [chemical binding]; other site
449447001240	metal-binding site [ion binding]
449447001241	ATP binding site [chemical binding]; other site
449447001242	flavoprotein, HI0933 family; Region: TIGR00275
449447001243	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447001244	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
449447001245	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
449447001246	Walker A/P-loop; other site
449447001247	ATP binding site [chemical binding]; other site
449447001248	Q-loop/lid; other site
449447001249	ABC transporter signature motif; other site
449447001250	Walker B; other site
449447001251	D-loop; other site
449447001252	H-loop/switch region; other site
449447001253	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
449447001254	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
449447001255	Walker A/P-loop; other site
449447001256	ATP binding site [chemical binding]; other site
449447001257	Q-loop/lid; other site
449447001258	ABC transporter signature motif; other site
449447001259	Walker B; other site
449447001260	D-loop; other site
449447001261	H-loop/switch region; other site
449447001262	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
449447001263	TM-ABC transporter signature motif; other site
449447001264	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
449447001265	TM-ABC transporter signature motif; other site
449447001266	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
449447001267	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
449447001268	putative ligand binding site [chemical binding]; other site
449447001269	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
449447001270	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
449447001271	VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457
449447001272	metal ion-dependent adhesion site (MIDAS); other site
449447001273	glycogen synthase; Provisional; Region: glgA; PRK00654
449447001274	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
449447001275	ADP-binding pocket [chemical binding]; other site
449447001276	homodimer interface [polypeptide binding]; other site
449447001277	Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664
449447001278	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
449447001279	16S/18S rRNA binding site [nucleotide binding]; other site
449447001280	S13e-L30e interaction site [polypeptide binding]; other site
449447001281	25S rRNA binding site [nucleotide binding]; other site
449447001282	Protein of unknown function (DUF3464); Region: DUF3464; pfam11947
449447001283	3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396
449447001284	NeuB family; Region: NeuB; cl00496
449447001285	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447001286	putative active site [active]
449447001287	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447001288	putative active site [active]
449447001289	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
449447001290	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
449447001291	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
449447001292	Dienelactone hydrolase family; Region: DLH; pfam01738
449447001293	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
449447001294	30S ribosomal protein S1; Reviewed; Region: PRK07400
449447001295	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
449447001296	RNA binding site [nucleotide binding]; other site
449447001297	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
449447001298	RNA binding site [nucleotide binding]; other site
449447001299	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
449447001300	RNA binding site [nucleotide binding]; other site
449447001301	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447001302	S-adenosylmethionine binding site [chemical binding]; other site
449447001303	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
449447001304	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447001305	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447001306	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447001307	Transposase [DNA replication, recombination, and repair]; Region: COG5433
449447001308	Protein of unknown function (DUF760); Region: DUF760; pfam05542
449447001309	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
449447001310	Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643
449447001311	active site
449447001312	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
449447001313	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
449447001314	Walker A/P-loop; other site
449447001315	ATP binding site [chemical binding]; other site
449447001316	Q-loop/lid; other site
449447001317	ABC transporter signature motif; other site
449447001318	Walker B; other site
449447001319	D-loop; other site
449447001320	H-loop/switch region; other site
449447001321	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
449447001322	Transposase domain (DUF772); Region: DUF772; cl15789
449447001323	Transposase domain (DUF772); Region: DUF772; cl15789
449447001324	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
449447001325	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
449447001326	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546
449447001327	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
449447001328	Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930
449447001329	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
449447001330	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
449447001331	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
449447001332	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
449447001333	YcfA-like protein; Region: YcfA; cl00752
449447001334	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
449447001335	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
449447001336	hydrophobic ligand binding site; other site
449447001337	Protein of unknown function (DUF1499); Region: DUF1499; cl01841
449447001338	Domain of unknown function (DUF427); Region: DUF427; cl00998
449447001339	UbiA prenyltransferase family; Region: UbiA; cl00337
449447001340	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
449447001341	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
449447001342	Ligand Binding Site [chemical binding]; other site
449447001343	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433
449447001344	Ion transport protein; Region: Ion_trans; pfam00520
449447001345	Ion channel; Region: Ion_trans_2; cl11596
449447001346	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
449447001347	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
449447001348	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
449447001349	Ycf39; Provisional; Region: ycf39; CHL00194
449447001350	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
449447001351	NAD(P) binding site [chemical binding]; other site
449447001352	putative active site [active]
449447001353	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
449447001354	dimer interface [polypeptide binding]; other site
449447001355	catalytic triad [active]
449447001356	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447001357	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447001358	Cupin domain; Region: Cupin_2; cl09118
449447001359	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
449447001360	dihydropteroate synthase; Region: DHPS; TIGR01496
449447001361	substrate binding pocket [chemical binding]; other site
449447001362	dimer interface [polypeptide binding]; other site
449447001363	inhibitor binding site; inhibition site
449447001364	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
449447001365	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
449447001366	active site
449447001367	(T/H)XGH motif; other site
449447001368	Domain of unknown function (DUF427); Region: DUF427; cl00998
449447001369	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
449447001370	catalytic residues [active]
449447001371	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
449447001372	methionine aminopeptidase; Provisional; Region: PRK08671
449447001373	active site
449447001374	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
449447001375	Ligand Binding Site [chemical binding]; other site
449447001376	Protein of unknown function (DUF2811); Region: DUF2811; pfam10929
449447001377	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
449447001378	putative active site [active]
449447001379	catalytic residue [active]
449447001380	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
449447001381	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
449447001382	VPS10 domain; Region: VPS10; smart00602
449447001383	fumarate hydratase; Reviewed; Region: fumC; PRK00485
449447001384	Class II fumarases; Region: Fumarase_classII; cd01362
449447001385	active site
449447001386	tetramer interface [polypeptide binding]; other site
449447001387	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
449447001388	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
449447001389	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
449447001390	Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085
449447001391	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447001392	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
449447001393	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
449447001394	Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651
449447001395	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
449447001396	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447001397	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
449447001398	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
449447001399	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
449447001400	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
449447001401	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
449447001402	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
449447001403	P-loop; other site
449447001404	Magnesium ion binding site [ion binding]; other site
449447001405	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
449447001406	Magnesium ion binding site [ion binding]; other site
449447001407	ParB-like partition proteins; Region: parB_part; TIGR00180
449447001408	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447001409	putative active site [active]
449447001410	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447001411	putative active site [active]
449447001412	deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556
449447001413	DNA photolyase; Region: DNA_photolyase; pfam00875
449447001414	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
449447001415	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
449447001416	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
449447001417	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
449447001418	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
449447001419	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
449447001420	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
449447001421	GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450
449447001422	GIY-YIG motif/motif A; other site
449447001423	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447001424	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447001425	Protein of unknown function (DUF3593); Region: DUF3593; pfam12159
449447001426	Protein of unknown function (DUF2499); Region: DUF2499; pfam10693
449447001427	glutathione synthetase; Provisional; Region: PRK05246
449447001428	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
449447001429	ATP-grasp domain; Region: ATP-grasp_4; cl03087
449447001430	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
449447001431	GSH binding site [chemical binding]; other site
449447001432	catalytic residues [active]
449447001433	YGGT family; Region: YGGT; cl00508
449447001434	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
449447001435	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
449447001436	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
449447001437	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
449447001438	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
449447001439	putative phosphate binding site [ion binding]; other site
449447001440	putative catalytic site [active]
449447001441	active site
449447001442	metal binding site A [ion binding]; metal-binding site
449447001443	DNA binding site [nucleotide binding]
449447001444	putative AP binding site [nucleotide binding]; other site
449447001445	putative metal binding site B [ion binding]; other site
449447001446	Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514
449447001447	Fatty acid desaturase; Region: FA_desaturase; pfam00487
449447001448	putative di-iron ligands [ion binding]; other site
449447001449	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
449447001450	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912
449447001451	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447001452	Helix-turn-helix domains; Region: HTH; cl00088
449447001453	Integrase core domain; Region: rve; cl01316
449447001454	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447001455	Helix-turn-helix domains; Region: HTH; cl00088
449447001456	Winged helix-turn helix; Region: HTH_29; pfam13551
449447001457	Winged helix-turn helix; Region: HTH_33; pfam13592
449447001458	Integrase core domain; Region: rve; cl01316
449447001459	Transposase domain (DUF772); Region: DUF772; cl15789
449447001460	Transposase domain (DUF772); Region: DUF772; cl15789
449447001461	PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855
449447001462	putative active site [active]
449447001463	Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136
449447001464	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
449447001465	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
449447001466	active site
449447001467	dimer interface [polypeptide binding]; other site
449447001468	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
449447001469	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
449447001470	active site
449447001471	FMN binding site [chemical binding]; other site
449447001472	substrate binding site [chemical binding]; other site
449447001473	3Fe-4S cluster binding site [ion binding]; other site
449447001474	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
449447001475	domain interface; other site
449447001476	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447001477	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447001478	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
449447001479	hypothetical protein; Region: PHA00733
449447001480	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447001481	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
449447001482	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883
449447001483	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
449447001484	nucleophilic elbow; other site
449447001485	catalytic triad; other site
449447001486	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
449447001487	Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327
449447001488	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
449447001489	Sporulation and spore germination; Region: Germane; cl11253
449447001490	Mechanosensitive ion channel; Region: MS_channel; pfam00924
449447001491	Cytochrome c; Region: Cytochrom_C; cl11414
449447001492	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
449447001493	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
449447001494	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
449447001495	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447001496	Transposase domain (DUF772); Region: DUF772; cl15789
449447001497	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
449447001498	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
449447001499	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
449447001500	Malic enzyme, N-terminal domain; Region: malic; pfam00390
449447001501	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
449447001502	putative NAD(P) binding site [chemical binding]; other site
449447001503	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
449447001504	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
449447001505	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447001506	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
449447001507	PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388
449447001508	PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388
449447001509	PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388
449447001510	PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388
449447001511	PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388
449447001512	PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388
449447001513	PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388
449447001514	PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388
449447001515	HEAT repeats; Region: HEAT_2; pfam13646
449447001516	PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388
449447001517	PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388
449447001518	HEAT repeat; Region: HEAT; pfam02985
449447001519	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447001520	TIR domain; Region: TIR_2; cl15770
449447001521	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
449447001522	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
449447001523	PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388
449447001524	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
449447001525	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
449447001526	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
449447001527	active site
449447001528	putative substrate binding region [chemical binding]; other site
449447001529	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
449447001530	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
449447001531	putative active site [active]
449447001532	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
449447001533	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
449447001534	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
449447001535	Protein of unknown function DUF86; Region: DUF86; cl01031
449447001536	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
449447001537	active site
449447001538	NTP binding site [chemical binding]; other site
449447001539	metal binding triad [ion binding]; metal-binding site
449447001540	antibiotic binding site [chemical binding]; other site
449447001541	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
449447001542	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
449447001543	spermine synthase; Region: PLN02823
449447001544	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447001545	S-adenosylmethionine binding site [chemical binding]; other site
449447001546	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
449447001547	DHH family; Region: DHH; pfam01368
449447001548	DHHA1 domain; Region: DHHA1; pfam02272
449447001549	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
449447001550	MoaE interaction surface [polypeptide binding]; other site
449447001551	MoeB interaction surface [polypeptide binding]; other site
449447001552	thiocarboxylated glycine; other site
449447001553	exonuclease SbcC; Region: sbcc; TIGR00618
449447001554	SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279
449447001555	Walker A/P-loop; other site
449447001556	ATP binding site [chemical binding]; other site
449447001557	Q-loop/lid; other site
449447001558	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447001559	ABC transporter signature motif; other site
449447001560	Walker B; other site
449447001561	D-loop; other site
449447001562	H-loop/switch region; other site
449447001563	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
449447001564	Member of the Rhodanese Homology Domain superfamily, subgroup 2. Subgroup 2 includes uncharacterized putative rhodanese-related domains; Region: RHOD_2; cd01528
449447001565	active site residue [active]
449447001566	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
449447001567	HrcA protein C terminal domain; Region: HrcA; pfam01628
449447001568	Winged helix-turn helix; Region: HTH_29; pfam13551
449447001569	Helix-turn-helix domains; Region: HTH; cl00088
449447001570	Predicted helicase [General function prediction only]; Region: COG4889
449447001571	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447001572	lipoyl synthase; Provisional; Region: PRK05481
449447001573	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447001574	FeS/SAM binding site; other site
449447001575	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
449447001576	active site
449447001577	dimerization interface [polypeptide binding]; other site
449447001578	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
449447001579	MoaE homodimer interface [polypeptide binding]; other site
449447001580	MoaD interaction [polypeptide binding]; other site
449447001581	active site residues [active]
449447001582	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
449447001583	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
449447001584	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447001585	FeS/SAM binding site; other site
449447001586	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
449447001587	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
449447001588	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
449447001589	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
449447001590	NAD(P) binding site [chemical binding]; other site
449447001591	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
449447001592	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
449447001593	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
449447001594	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
449447001595	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
449447001596	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
449447001597	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
449447001598	active site
449447001599	substrate binding pocket [chemical binding]; other site
449447001600	dimer interface [polypeptide binding]; other site
449447001601	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447001602	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447001603	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447001604	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447001605	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447001606	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
449447001607	Restriction endonuclease; Region: Mrr_cat; cl00516
449447001608	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447001609	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
449447001610	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447001611	putative active site [active]
449447001612	Protein of unknown function (DUF3326); Region: DUF3326; pfam11805
449447001613	CAAX protease self-immunity; Region: Abi; cl00558
449447001614	Protein of unknown function (DUF3531); Region: DUF3531; pfam12049
449447001615	Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354
449447001616	beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215
449447001617	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801
449447001618	Protein of unknown function (DUF563); Region: DUF563; cl15705
449447001619	putative oxidoreductase; Provisional; Region: PRK12831
449447001620	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
449447001621	dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062
449447001622	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
449447001623	iron-sulfur cluster [ion binding]; other site
449447001624	[2Fe-2S] cluster binding site [ion binding]; other site
449447001625	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
449447001626	Protein of unknown function (DUF1361); Region: DUF1361; cl01784
449447001627	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
449447001628	active site
449447001629	Protein of unknown function (DUF3529); Region: DUF3529; pfam12046
449447001630	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
449447001631	ABC-ATPase subunit  interface; other site
449447001632	dimer interface [polypeptide binding]; other site
449447001633	putative PBP binding regions; other site
449447001634	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
449447001635	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
449447001636	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
449447001637	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
449447001638	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
449447001639	Hexamer interface [polypeptide binding]; other site
449447001640	Hexagonal pore residue; other site
449447001641	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
449447001642	Hexamer interface [polypeptide binding]; other site
449447001643	Hexagonal pore residue; other site
449447001644	Restriction endonuclease EcoRI; Region: EcoRI; pfam02963
449447001645	Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651
449447001646	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
449447001647	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447001648	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447001649	PemK-like protein; Region: PemK; cl00995
449447001650	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447001651	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447001652	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
449447001653	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
449447001654	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
449447001655	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668
449447001656	UTRA domain; Region: UTRA; cl01230
449447001657	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
449447001658	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
449447001659	C-terminal domain interface [polypeptide binding]; other site
449447001660	GSH binding site (G-site) [chemical binding]; other site
449447001661	dimer interface [polypeptide binding]; other site
449447001662	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
449447001663	N-terminal domain interface [polypeptide binding]; other site
449447001664	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
449447001665	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
449447001666	Catalytic site [active]
449447001667	Domain of unknown function (DUF1818); Region: DUF1818; pfam08848
449447001668	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
449447001669	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
449447001670	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
449447001671	putative substrate binding site [chemical binding]; other site
449447001672	putative ATP binding site [chemical binding]; other site
449447001673	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
449447001674	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
449447001675	Coenzyme A binding pocket [chemical binding]; other site
449447001676	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
449447001677	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447001678	dimer interface [polypeptide binding]; other site
449447001679	phosphorylation site [posttranslational modification]
449447001680	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
449447001681	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447001682	Transposase domain (DUF772); Region: DUF772; cl15789
449447001683	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
449447001684	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
449447001685	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
449447001686	Ligand binding site; other site
449447001687	Putative Catalytic site; other site
449447001688	DXD motif; other site
449447001689	Protein of unknown function (DUF1092); Region: DUF1092; pfam06485
449447001690	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
449447001691	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
449447001692	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
449447001693	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
449447001694	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
449447001695	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
449447001696	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
449447001697	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
449447001698	YcfA-like protein; Region: YcfA; cl00752
449447001699	RelB antitoxin; Region: RelB; cl01171
449447001700	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
449447001701	YcfA-like protein; Region: YcfA; cl00752
449447001702	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
449447001703	BT1 family; Region: BT1; pfam03092
449447001704	putative substrate translocation pore; other site
449447001705	Probable transposase; Region: OrfB_IS605; pfam01385
449447001706	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
449447001707	Cadmium resistance transporter; Region: Cad; cl04177
449447001708	calcium/proton exchanger (cax); Region: cax; TIGR00378
449447001709	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
449447001710	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
449447001711	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14265
449447001712	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
449447001713	Walker A/P-loop; other site
449447001714	ATP binding site [chemical binding]; other site
449447001715	Q-loop/lid; other site
449447001716	ABC transporter signature motif; other site
449447001717	Walker B; other site
449447001718	D-loop; other site
449447001719	H-loop/switch region; other site
449447001720	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447001721	dimer interface [polypeptide binding]; other site
449447001722	conserved gate region; other site
449447001723	putative PBP binding loops; other site
449447001724	ABC-ATPase subunit interface; other site
449447001725	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
449447001726	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447001727	dimer interface [polypeptide binding]; other site
449447001728	conserved gate region; other site
449447001729	putative PBP binding loops; other site
449447001730	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
449447001731	ABC-ATPase subunit interface; other site
449447001732	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
449447001733	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447001734	Transposase domain (DUF772); Region: DUF772; cl15789
449447001735	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
449447001736	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
449447001737	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
449447001738	Cadmium resistance transporter; Region: Cad; cl04177
449447001739	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
449447001740	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
449447001741	substrate binding pocket [chemical binding]; other site
449447001742	membrane-bound complex binding site; other site
449447001743	hinge residues; other site
449447001744	Probable transposase; Region: OrfB_IS605; pfam01385
449447001745	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447001746	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
449447001747	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
449447001748	DNA binding residues [nucleotide binding]
449447001749	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
449447001750	catalytic residues [active]
449447001751	catalytic nucleophile [active]
449447001752	RNA polymerase sigma factor SigC; Validated; Region: PRK07598
449447001753	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
449447001754	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
449447001755	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
449447001756	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
449447001757	DNA binding residues [nucleotide binding]
449447001758	hypothetical protein; Provisional; Region: PRK07394
449447001759	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
449447001760	Transcriptional regulator [Transcription]; Region: LysR; COG0583
449447001761	Helix-turn-helix domains; Region: HTH; cl00088
449447001762	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
449447001763	dimerization interface [polypeptide binding]; other site
449447001764	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
449447001765	putative catalytic site [active]
449447001766	putative metal binding site [ion binding]; other site
449447001767	putative phosphate binding site [ion binding]; other site
449447001768	Fibronectin type III-like domain; Region: Fn3-like; cl15273
449447001769	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
449447001770	active site
449447001771	Protein of unknown function, DUF393; Region: DUF393; cl01136
449447001772	Integral membrane protein TerC family; Region: TerC; cl10468
449447001773	Photosystem I protein M (PsaM); Region: PsaM; cl15374
449447001774	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447001775	Helix-turn-helix domains; Region: HTH; cl00088
449447001776	Integrase core domain; Region: rve; cl01316
449447001777	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
449447001778	THUMP domain; Region: THUMP; cl12076
449447001779	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447001780	malate dehydrogenase; Reviewed; Region: PRK06223
449447001781	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
449447001782	NAD(P) binding site [chemical binding]; other site
449447001783	dimer interface [polypeptide binding]; other site
449447001784	tetramer (dimer of dimers) interface [polypeptide binding]; other site
449447001785	substrate binding site [chemical binding]; other site
449447001786	Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910
449447001787	Uncharacterized BCR, COG1649; Region: DUF187; cl15398
449447001788	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705
449447001789	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447001790	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
449447001791	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
449447001792	Protein of unknown function (DUF3747); Region: DUF3747; pfam12565
449447001793	peptide chain release factor 2; Provisional; Region: PRK05589
449447001794	RF-1 domain; Region: RF-1; cl02875
449447001795	RF-1 domain; Region: RF-1; cl02875
449447001796	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
449447001797	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
449447001798	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
449447001799	Divergent AAA domain; Region: AAA_4; pfam04326
449447001800	ferrochelatase; Reviewed; Region: hemH; PRK00035
449447001801	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
449447001802	active site
449447001803	C-terminal domain interface [polypeptide binding]; other site
449447001804	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
449447001805	active site
449447001806	N-terminal domain interface [polypeptide binding]; other site
449447001807	Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879
449447001808	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447001809	S-adenosylmethionine binding site [chemical binding]; other site
449447001810	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
449447001811	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
449447001812	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447001813	S-adenosylmethionine binding site [chemical binding]; other site
449447001814	ketol-acid reductoisomerase; Provisional; Region: PRK05479
449447001815	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447001816	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
449447001817	type IV pilus assembly protein PilM; Region: pilM; TIGR01175
449447001818	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
449447001819	Pilus assembly protein, PilO; Region: PilO; cl01234
449447001820	Secretin and TonB N terminus short domain; Region: STN; cl06624
449447001821	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
449447001822	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
449447001823	Protein of unknown function (DUF751); Region: DUF751; pfam05421
449447001824	Ribosome-binding factor A; Region: RBFA; cl00542
449447001825	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
449447001826	conserved hypothetical protein; Region: TIGR03492
449447001827	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
449447001828	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
449447001829	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
449447001830	amphipathic channel; other site
449447001831	Asn-Pro-Ala signature motifs; other site
449447001832	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
449447001833	Helix-turn-helix domains; Region: HTH; cl00088
449447001834	Winged helix-turn helix; Region: HTH_29; pfam13551
449447001835	Winged helix-turn helix; Region: HTH_33; pfam13592
449447001836	Integrase core domain; Region: rve; cl01316
449447001837	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447001838	Integrase core domain; Region: rve; cl01316
449447001839	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447001840	Helix-turn-helix domains; Region: HTH; cl00088
449447001841	DNA binding site [nucleotide binding]
449447001842	Winged helix-turn helix; Region: HTH_29; pfam13551
449447001843	Helix-turn-helix domains; Region: HTH; cl00088
449447001844	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447001845	Transposase domain (DUF772); Region: DUF772; cl15789
449447001846	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
449447001847	Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085
449447001848	Domain of unknown function (DUF4415); Region: DUF4415; cl01401
449447001849	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
449447001850	Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085
449447001851	S-layer homology domain; Region: SLH; pfam00395
449447001852	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
449447001853	Transposase domain (DUF772); Region: DUF772; cl15789
449447001854	Transposase domain (DUF772); Region: DUF772; cl15789
449447001855	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
449447001856	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
449447001857	HSP70 interaction site [polypeptide binding]; other site
449447001858	Protein of unknown function (DUF3143); Region: DUF3143; pfam11341
449447001859	radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167
449447001860	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447001861	FeS/SAM binding site; other site
449447001862	Protein of unknown function (DUF3641); Region: DUF3641; pfam12345
449447001863	Methyltransferase domain; Region: Methyltransf_31; pfam13847
449447001864	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447001865	S-adenosylmethionine binding site [chemical binding]; other site
449447001866	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447001867	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447001868	Integrase core domain; Region: rve; cl01316
449447001869	Helix-turn-helix domains; Region: HTH; cl00088
449447001870	DNA binding site [nucleotide binding]
449447001871	Winged helix-turn helix; Region: HTH_29; pfam13551
449447001872	Helix-turn-helix domains; Region: HTH; cl00088
449447001873	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447001874	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447001875	Probable transposase; Region: OrfB_IS605; pfam01385
449447001876	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447001877	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
449447001878	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
449447001879	protein I interface; other site
449447001880	D2 interface; other site
449447001881	protein T interface; other site
449447001882	chlorophyll binding site; other site
449447001883	beta carotene binding site; other site
449447001884	pheophytin binding site; other site
449447001885	manganese-stabilizing polypeptide interface; other site
449447001886	CP43 interface; other site
449447001887	protein L interface; other site
449447001888	oxygen evolving complex binding site; other site
449447001889	bromide binding site; other site
449447001890	quinone binding site; other site
449447001891	Fe binding site [ion binding]; other site
449447001892	core light harvesting interface; other site
449447001893	cytochrome b559 alpha subunit interface; other site
449447001894	cytochrome c-550 interface; other site
449447001895	protein J interface; other site
449447001896	methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841
449447001897	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
449447001898	CpcD/allophycocyanin linker domain; Region: CpcD; cl03191
449447001899	Phycobilisome protein; Region: Phycobilisome; cl08227
449447001900	Phycobilisome protein; Region: Phycobilisome; cl08227
449447001901	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
449447001902	RuvA N terminal domain; Region: RuvA_N; pfam01330
449447001903	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
449447001904	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
449447001905	active site
449447001906	putative substrate binding region [chemical binding]; other site
449447001907	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50.  CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801
449447001908	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
449447001909	Helix-turn-helix domains; Region: HTH; cl00088
449447001910	Winged helix-turn helix; Region: HTH_29; pfam13551
449447001911	Winged helix-turn helix; Region: HTH_33; pfam13592
449447001912	Integrase core domain; Region: rve; cl01316
449447001913	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
449447001914	proposed catalytic triad [active]
449447001915	active site nucleophile [active]
449447001916	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
449447001917	Sodium:solute symporter family; Region: SSF; cl00456
449447001918	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
449447001919	cyanate hydratase; Validated; Region: PRK02866
449447001920	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
449447001921	oligomer interface [polypeptide binding]; other site
449447001922	active site
449447001923	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
449447001924	protein I interface; other site
449447001925	D2 interface; other site
449447001926	protein T interface; other site
449447001927	chlorophyll binding site; other site
449447001928	beta carotene binding site; other site
449447001929	pheophytin binding site; other site
449447001930	manganese-stabilizing polypeptide interface; other site
449447001931	CP43 interface; other site
449447001932	protein L interface; other site
449447001933	oxygen evolving complex binding site; other site
449447001934	bromide binding site; other site
449447001935	quinone binding site; other site
449447001936	Fe binding site [ion binding]; other site
449447001937	core light harvesting interface; other site
449447001938	cytochrome b559 alpha subunit interface; other site
449447001939	cytochrome c-550 interface; other site
449447001940	protein J interface; other site
449447001941	PemK-like protein; Region: PemK; cl00995
449447001942	D1, D2 subunits of photosystem II  (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220
449447001943	Protein of unknown function (DUF433); Region: DUF433; cl01030
449447001944	Helix-turn-helix domains; Region: HTH; cl00088
449447001945	Winged helix-turn helix; Region: HTH_29; pfam13551
449447001946	Helix-turn-helix domains; Region: HTH; cl00088
449447001947	Integrase core domain; Region: rve; cl01316
449447001948	Helix-turn-helix domains; Region: HTH; cl00088
449447001949	DNA binding site [nucleotide binding]
449447001950	Winged helix-turn helix; Region: HTH_29; pfam13551
449447001951	Helix-turn-helix domains; Region: HTH; cl00088
449447001952	Integrase core domain; Region: rve; cl01316
449447001953	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447001954	NB-ARC domain; Region: NB-ARC; pfam00931
449447001955	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
449447001956	protein I interface; other site
449447001957	D2 interface; other site
449447001958	protein T interface; other site
449447001959	chlorophyll binding site; other site
449447001960	beta carotene binding site; other site
449447001961	pheophytin binding site; other site
449447001962	manganese-stabilizing polypeptide interface; other site
449447001963	CP43 interface; other site
449447001964	protein L interface; other site
449447001965	oxygen evolving complex binding site; other site
449447001966	bromide binding site; other site
449447001967	quinone binding site; other site
449447001968	Fe binding site [ion binding]; other site
449447001969	core light harvesting interface; other site
449447001970	cytochrome b559 alpha subunit interface; other site
449447001971	cytochrome c-550 interface; other site
449447001972	protein J interface; other site
449447001973	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447001974	putative active site [active]
449447001975	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
449447001976	Archaeal ATPase; Region: Arch_ATPase; pfam01637
449447001977	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447001978	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
449447001979	metal ion-dependent adhesion site (MIDAS); other site
449447001980	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
449447001981	active site
449447001982	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
449447001983	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447001984	Helix-turn-helix domains; Region: HTH; cl00088
449447001985	DNA binding site [nucleotide binding]
449447001986	Winged helix-turn helix; Region: HTH_29; pfam13551
449447001987	Helix-turn-helix domains; Region: HTH; cl00088
449447001988	Integrase core domain; Region: rve; cl01316
449447001989	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447001990	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447001991	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447001992	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
449447001993	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
449447001994	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
449447001995	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447001996	Helix-turn-helix domains; Region: HTH; cl00088
449447001997	Winged helix-turn helix; Region: HTH_29; pfam13551
449447001998	Helix-turn-helix domains; Region: HTH; cl00088
449447001999	Integrase core domain; Region: rve; cl01316
449447002000	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447002001	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447002002	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447002003	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
449447002004	protein I interface; other site
449447002005	D2 interface; other site
449447002006	protein T interface; other site
449447002007	chlorophyll binding site; other site
449447002008	beta carotene binding site; other site
449447002009	pheophytin binding site; other site
449447002010	manganese-stabilizing polypeptide interface; other site
449447002011	CP43 interface; other site
449447002012	protein L interface; other site
449447002013	oxygen evolving complex binding site; other site
449447002014	bromide binding site; other site
449447002015	quinone binding site; other site
449447002016	Fe binding site [ion binding]; other site
449447002017	core light harvesting interface; other site
449447002018	cytochrome b559 alpha subunit interface; other site
449447002019	cytochrome c-550 interface; other site
449447002020	protein J interface; other site
449447002021	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
449447002022	substrate binding site; other site
449447002023	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447002024	Transposase domain (DUF772); Region: DUF772; cl15789
449447002025	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
449447002026	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
449447002027	NAD binding site [chemical binding]; other site
449447002028	homotetramer interface [polypeptide binding]; other site
449447002029	homodimer interface [polypeptide binding]; other site
449447002030	substrate binding site [chemical binding]; other site
449447002031	active site
449447002032	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
449447002033	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
449447002034	inhibitor-cofactor binding pocket; inhibition site
449447002035	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447002036	catalytic residue [active]
449447002037	Cupin domain; Region: Cupin_2; cl09118
449447002038	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
449447002039	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447002040	NAD(P) binding site [chemical binding]; other site
449447002041	active site
449447002042	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
449447002043	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
449447002044	Ligand binding site; other site
449447002045	Putative Catalytic site; other site
449447002046	DXD motif; other site
449447002047	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447002048	putative active site [active]
449447002049	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
449447002050	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
449447002051	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
449447002052	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
449447002053	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
449447002054	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447002055	NAD(P) binding site [chemical binding]; other site
449447002056	active site
449447002057	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
449447002058	TPP-binding site [chemical binding]; other site
449447002059	dimer interface [polypeptide binding]; other site
449447002060	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
449447002061	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
449447002062	PYR/PP interface [polypeptide binding]; other site
449447002063	dimer interface [polypeptide binding]; other site
449447002064	TPP binding site [chemical binding]; other site
449447002065	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
449447002066	GtrA-like protein; Region: GtrA; cl00971
449447002067	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
449447002068	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
449447002069	Ligand binding site; other site
449447002070	Putative Catalytic site; other site
449447002071	DXD motif; other site
449447002072	YCII-related domain; Region: YCII; cl00999
449447002073	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
449447002074	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
449447002075	Walker A/P-loop; other site
449447002076	ATP binding site [chemical binding]; other site
449447002077	Q-loop/lid; other site
449447002078	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
449447002079	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
449447002080	ABC transporter signature motif; other site
449447002081	Walker B; other site
449447002082	D-loop; other site
449447002083	H-loop/switch region; other site
449447002084	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
449447002085	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
449447002086	B12 binding site [chemical binding]; other site
449447002087	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447002088	FeS/SAM binding site; other site
449447002089	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447002090	structural tetrad; other site
449447002091	DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625
449447002092	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
449447002093	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
449447002094	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
449447002095	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
449447002096	homotrimer interaction site [polypeptide binding]; other site
449447002097	putative active site [active]
449447002098	Protein of unknown function DUF262; Region: DUF262; cl14890
449447002099	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
449447002100	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
449447002101	P-loop; other site
449447002102	Magnesium ion binding site [ion binding]; other site
449447002103	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
449447002104	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
449447002105	HIGH motif; other site
449447002106	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
449447002107	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
449447002108	active site
449447002109	KMSKS motif; other site
449447002110	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
449447002111	tRNA binding surface [nucleotide binding]; other site
449447002112	anticodon binding site; other site
449447002113	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
449447002114	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447002115	putative active site [active]
449447002116	Bacterial sugar transferase; Region: Bac_transf; cl00939
449447002117	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447002118	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447002119	Transposase [DNA replication, recombination, and repair]; Region: COG5433
449447002120	RRXRR protein; Region: RRXRR; pfam14239
449447002121	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
449447002122	putative active site [active]
449447002123	Double zinc ribbon; Region: DZR; pfam12773
449447002124	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
449447002125	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
449447002126	phosphopeptide binding site; other site
449447002127	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
449447002128	active site
449447002129	putative substrate binding region [chemical binding]; other site
449447002130	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
449447002131	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
449447002132	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
449447002133	active site
449447002134	metal binding site [ion binding]; metal-binding site
449447002135	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
449447002136	dimer interface [polypeptide binding]; other site
449447002137	substrate binding site [chemical binding]; other site
449447002138	catalytic triad [active]
449447002139	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
449447002140	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
449447002141	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
449447002142	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447002143	putative active site [active]
449447002144	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
449447002145	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447002146	putative active site [active]
449447002147	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447002148	putative active site [active]
449447002149	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552
449447002150	30S subunit binding site; other site
449447002151	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
449447002152	putative dimer interface [polypeptide binding]; other site
449447002153	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
449447002154	Protein of unknown function DUF111; Region: DUF111; cl03398
449447002155	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447002156	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447002157	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102
449447002158	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
449447002159	active site
449447002160	NTP binding site [chemical binding]; other site
449447002161	metal binding triad [ion binding]; metal-binding site
449447002162	antibiotic binding site [chemical binding]; other site
449447002163	AAA domain; Region: AAA_13; pfam13166
449447002164	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447002165	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447002166	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447002167	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447002168	Transposase domain (DUF772); Region: DUF772; cl15789
449447002169	Peptidase family M48; Region: Peptidase_M48; cl12018
449447002170	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
449447002171	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
449447002172	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
449447002173	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
449447002174	metal ion-dependent adhesion site (MIDAS); other site
449447002175	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447002176	Probable transposase; Region: OrfB_IS605; pfam01385
449447002177	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447002178	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
449447002179	NADH dehydrogenase subunit B; Validated; Region: PRK06411
449447002180	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
449447002181	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771
449447002182	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
449447002183	Predicted ATPases [General function prediction only]; Region: COG1106
449447002184	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447002185	Walker A/P-loop; other site
449447002186	ATP binding site [chemical binding]; other site
449447002187	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447002188	Q-loop/lid; other site
449447002189	ABC transporter signature motif; other site
449447002190	Walker B; other site
449447002191	D-loop; other site
449447002192	H-loop/switch region; other site
449447002193	Cytochrome c; Region: Cytochrom_C; cl11414
449447002194	Domain of unknown function (DUF370); Region: DUF370; cl00898
449447002195	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
449447002196	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
449447002197	catalytic site [active]
449447002198	G-X2-G-X-G-K; other site
449447002199	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447002200	Probable transposase; Region: OrfB_IS605; pfam01385
449447002201	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447002202	Clp protease; Region: CLP_protease; pfam00574
449447002203	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
449447002204	oligomer interface [polypeptide binding]; other site
449447002205	active site residues [active]
449447002206	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
449447002207	tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449
449447002208	Photosystem II 4 kDa reaction centre component; Region: PsbK; cl03641
449447002209	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447002210	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
449447002211	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447002212	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447002213	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
449447002214	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447002215	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447002216	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
449447002217	dimerization interface [polypeptide binding]; other site
449447002218	putative DNA binding site [nucleotide binding]; other site
449447002219	putative Zn2+ binding site [ion binding]; other site
449447002220	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
449447002221	Amidase; Region: Amidase; cl11426
449447002222	Fic/DOC family; Region: Fic; cl00960
449447002223	Protein of unknown function DUF91; Region: DUF91; cl00709
449447002224	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447002225	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
449447002226	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
449447002227	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136
449447002228	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
449447002229	Protein of unknown function (DUF512); Region: DUF512; pfam04459
449447002230	Permease; Region: Permease; cl00510
449447002231	PUA domain; Region: PUA; cl00607
449447002232	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
449447002233	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
449447002234	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
449447002235	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
449447002236	active site
449447002237	metal binding site [ion binding]; metal-binding site
449447002238	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
449447002239	classical (c) SDRs; Region: SDR_c; cd05233
449447002240	NAD(P) binding site [chemical binding]; other site
449447002241	active site
449447002242	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
449447002243	active site
449447002244	reticulocyte binding protein 2-like protein; Provisional; Region: PTZ00440
449447002245	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
449447002246	magnesium chelatase subunit H; Provisional; Region: PRK12493
449447002247	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
449447002248	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
449447002249	HEPN domain; Region: HEPN; cl00824
449447002250	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
449447002251	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447002252	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
449447002253	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
449447002254	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447002255	active site
449447002256	phosphorylation site [posttranslational modification]
449447002257	intermolecular recognition site; other site
449447002258	dimerization interface [polypeptide binding]; other site
449447002259	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447002260	dimer interface [polypeptide binding]; other site
449447002261	phosphorylation site [posttranslational modification]
449447002262	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447002263	ATP binding site [chemical binding]; other site
449447002264	Mg2+ binding site [ion binding]; other site
449447002265	G-X-G motif; other site
449447002266	Response regulator receiver domain; Region: Response_reg; pfam00072
449447002267	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447002268	active site
449447002269	phosphorylation site [posttranslational modification]
449447002270	intermolecular recognition site; other site
449447002271	dimerization interface [polypeptide binding]; other site
449447002272	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
449447002273	GAF domain; Region: GAF; cl15785
449447002274	Phytochrome region; Region: PHY; pfam00360
449447002275	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447002276	dimer interface [polypeptide binding]; other site
449447002277	phosphorylation site [posttranslational modification]
449447002278	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447002279	ATP binding site [chemical binding]; other site
449447002280	Mg2+ binding site [ion binding]; other site
449447002281	G-X-G motif; other site
449447002282	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
449447002283	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
449447002284	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
449447002285	active site
449447002286	Zn binding site [ion binding]; other site
449447002287	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
449447002288	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447002289	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
449447002290	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
449447002291	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
449447002292	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
449447002293	NAD(P) binding site [chemical binding]; other site
449447002294	homodimer interface [polypeptide binding]; other site
449447002295	substrate binding site [chemical binding]; other site
449447002296	active site
449447002297	carotene isomerase; Region: carot_isom; TIGR02730
449447002298	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447002299	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
449447002300	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
449447002301	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
449447002302	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
449447002303	putative active site [active]
449447002304	catalytic triad [active]
449447002305	Calx-beta domain; Region: Calx-beta; cl02522
449447002306	Calx-beta domain; Region: Calx-beta; cl02522
449447002307	Calx-beta domain; Region: Calx-beta; cl02522
449447002308	Calx-beta domain; Region: Calx-beta; cl02522
449447002309	Calx-beta domain; Region: Calx-beta; cl02522
449447002310	Calx-beta domain; Region: Calx-beta; cl02522
449447002311	Calx-beta domain; Region: Calx-beta; cl02522
449447002312	Calx-beta domain; Region: Calx-beta; cl02522
449447002313	Calx-beta domain; Region: Calx-beta; cl02522
449447002314	Calx-beta domain; Region: Calx-beta; cl02522
449447002315	Calx-beta domain; Region: Calx-beta; cl02522
449447002316	Calx-beta domain; Region: Calx-beta; cl02522
449447002317	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
449447002318	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
449447002319	Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498
449447002320	active site
449447002321	catalytic triad [active]
449447002322	Calx-beta domain; Region: Calx-beta; cl02522
449447002323	Calx-beta domain; Region: Calx-beta; cl02522
449447002324	Calx-beta domain; Region: Calx-beta; cl02522
449447002325	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
449447002326	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
449447002327	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447002328	Walker A/P-loop; other site
449447002329	ATP binding site [chemical binding]; other site
449447002330	Q-loop/lid; other site
449447002331	ABC transporter signature motif; other site
449447002332	Walker B; other site
449447002333	D-loop; other site
449447002334	H-loop/switch region; other site
449447002335	TOBE domain; Region: TOBE_2; cl01440
449447002336	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
449447002337	ATP-grasp domain; Region: ATP-grasp_4; cl03087
449447002338	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447002339	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
449447002340	CHAT domain; Region: CHAT; pfam12770
449447002341	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447002342	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
449447002343	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457
449447002344	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447002345	FeS/SAM binding site; other site
449447002346	CpcD/allophycocyanin linker domain; Region: CpcD; cl03191
449447002347	CpcD/allophycocyanin linker domain; Region: CpcD; cl03191
449447002348	ferredoxin--NADP+ reductase; Provisional; Region: PLN03116
449447002349	These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208
449447002350	dimerization interface [polypeptide binding]; other site
449447002351	FAD binding pocket [chemical binding]; other site
449447002352	FAD binding motif [chemical binding]; other site
449447002353	catalytic residues [active]
449447002354	NAD binding pocket [chemical binding]; other site
449447002355	phosphate binding motif [ion binding]; other site
449447002356	beta-alpha-beta structure motif; other site
449447002357	Protein of unknown function, DUF399; Region: DUF399; cl01139
449447002358	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638
449447002359	active site
449447002360	Predicted GTPase [General function prediction only]; Region: COG3596
449447002361	YfjP GTPase; Region: YfjP; cd11383
449447002362	G1 box; other site
449447002363	GTP/Mg2+ binding site [chemical binding]; other site
449447002364	Switch I region; other site
449447002365	G2 box; other site
449447002366	Switch II region; other site
449447002367	G3 box; other site
449447002368	G4 box; other site
449447002369	Protein of unknown function (DUF497); Region: DUF497; cl01108
449447002370	alpha/beta hydrolase fold protein; Provisional; Region: PLN03084
449447002371	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
449447002372	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
449447002373	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
449447002374	Active Sites [active]
449447002375	Family description; Region: VCBS; pfam13517
449447002376	Family description; Region: VCBS; pfam13517
449447002377	Family description; Region: VCBS; pfam13517
449447002378	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
449447002379	Protein of unknown function (DUF1702); Region: DUF1702; pfam08012
449447002380	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
449447002381	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
449447002382	DevC protein; Region: devC; TIGR01185
449447002383	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
449447002384	FtsX-like permease family; Region: FtsX; cl15850
449447002385	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
449447002386	active site
449447002387	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
449447002388	putative active site [active]
449447002389	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
449447002390	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
449447002391	active site
449447002392	Acyl transferase domain; Region: Acyl_transf_1; cl08282
449447002393	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
449447002394	active site
449447002395	NAD binding site [chemical binding]; other site
449447002396	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
449447002397	putative NADP binding site [chemical binding]; other site
449447002398	active site
449447002399	FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493
449447002400	active site 2 [active]
449447002401	dimer interface [polypeptide binding]; other site
449447002402	active site 1 [active]
449447002403	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
449447002404	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
449447002405	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447002406	putative active site [active]
449447002407	Cupin domain; Region: Cupin_2; cl09118
449447002408	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
449447002409	active site lid residues [active]
449447002410	substrate binding pocket [chemical binding]; other site
449447002411	catalytic residues [active]
449447002412	substrate-Mg2+ binding site; other site
449447002413	aspartate-rich region 1; other site
449447002414	aspartate-rich region 2; other site
449447002415	phytoene desaturase; Region: phytoene_desat; TIGR02731
449447002416	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447002417	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
449447002418	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
449447002419	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
449447002420	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
449447002421	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
449447002422	motif II; other site
449447002423	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
449447002424	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
449447002425	transmembrane helices; other site
449447002426	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
449447002427	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
449447002428	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
449447002429	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
449447002430	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447002431	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447002432	binding surface
449447002433	TPR motif; other site
449447002434	TPR repeat; Region: TPR_11; pfam13414
449447002435	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
449447002436	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
449447002437	substrate binding pocket [chemical binding]; other site
449447002438	membrane-bound complex binding site; other site
449447002439	hinge residues; other site
449447002440	Response regulator receiver domain; Region: Response_reg; pfam00072
449447002441	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447002442	active site
449447002443	phosphorylation site [posttranslational modification]
449447002444	intermolecular recognition site; other site
449447002445	dimerization interface [polypeptide binding]; other site
449447002446	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
449447002447	metal binding site [ion binding]; metal-binding site
449447002448	active site
449447002449	I-site; other site
449447002450	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
449447002451	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
449447002452	ATP binding site [chemical binding]; other site
449447002453	putative Mg++ binding site [ion binding]; other site
449447002454	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
449447002455	nucleotide binding region [chemical binding]; other site
449447002456	ATP-binding site [chemical binding]; other site
449447002457	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
449447002458	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447002459	binding surface
449447002460	TPR motif; other site
449447002461	TPR repeat; Region: TPR_11; pfam13414
449447002462	TPR repeat; Region: TPR_11; pfam13414
449447002463	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447002464	binding surface
449447002465	TPR motif; other site
449447002466	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
449447002467	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
449447002468	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
449447002469	Peptidase family M23; Region: Peptidase_M23; pfam01551
449447002470	seryl-tRNA synthetase; Provisional; Region: PRK05431
449447002471	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
449447002472	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770
449447002473	dimer interface [polypeptide binding]; other site
449447002474	active site
449447002475	motif 1; other site
449447002476	motif 2; other site
449447002477	motif 3; other site
449447002478	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549
449447002479	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209
449447002480	dimer interface [polypeptide binding]; other site
449447002481	active site
449447002482	catalytic residue [active]
449447002483	metal binding site [ion binding]; metal-binding site
449447002484	cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924
449447002485	active site
449447002486	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
449447002487	active site
449447002488	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
449447002489	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
449447002490	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447002491	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447002492	Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119
449447002493	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
449447002494	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
449447002495	Exonuclease VII, large subunit; Region: Exonuc_VII_L; pfam02601
449447002496	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
449447002497	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447002498	S-adenosylmethionine binding site [chemical binding]; other site
449447002499	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447002500	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
449447002501	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447002502	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
449447002503	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
449447002504	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
449447002505	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
449447002506	proline aminopeptidase P II; Provisional; Region: PRK10879
449447002507	Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433
449447002508	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
449447002509	active site
449447002510	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447002511	putative active site [active]
449447002512	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447002513	putative active site [active]
449447002514	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
449447002515	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
449447002516	nucleotide binding pocket [chemical binding]; other site
449447002517	K-X-D-G motif; other site
449447002518	catalytic site [active]
449447002519	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
449447002520	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
449447002521	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
449447002522	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
449447002523	Dimer interface [polypeptide binding]; other site
449447002524	BRCT sequence motif; other site
449447002525	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447002526	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447002527	Protein of unknown function (DUF2996); Region: DUF2996; pfam11210
449447002528	Protein of unknown function (DUF3110); Region: DUF3110; pfam11360
449447002529	Restriction endonuclease; Region: Mrr_cat; cl00516
449447002530	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
449447002531	catalytic core [active]
449447002532	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
449447002533	catalytic core [active]
449447002534	birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121
449447002535	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
449447002536	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
449447002537	Peptidase family M23; Region: Peptidase_M23; pfam01551
449447002538	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
449447002539	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
449447002540	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
449447002541	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
449447002542	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447002543	Walker A/P-loop; other site
449447002544	ATP binding site [chemical binding]; other site
449447002545	Q-loop/lid; other site
449447002546	ABC transporter signature motif; other site
449447002547	Walker B; other site
449447002548	D-loop; other site
449447002549	H-loop/switch region; other site
449447002550	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
449447002551	active site
449447002552	metal binding site [ion binding]; metal-binding site
449447002553	Helix-turn-helix domains; Region: HTH; cl00088
449447002554	Helix-turn-helix domains; Region: HTH; cl00088
449447002555	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
449447002556	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447002557	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447002558	putative active site [active]
449447002559	GUN4-like; Region: GUN4; pfam05419
449447002560	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447002561	Transglycosylase; Region: Transgly; cl07896
449447002562	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
449447002563	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
449447002564	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
449447002565	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447002566	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447002567	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447002568	Transcriptional regulator; Region: Transcrip_reg; cl00361
449447002569	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
449447002570	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
449447002571	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780
449447002572	hypothetical protein; Reviewed; Region: PRK09588
449447002573	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
449447002574	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
449447002575	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447002576	NAD(P) binding site [chemical binding]; other site
449447002577	active site
449447002578	TolB amino-terminal domain; Region: TolB_N; cl00639
449447002579	succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577
449447002580	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
449447002581	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
449447002582	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
449447002583	CAAX protease self-immunity; Region: Abi; cl00558
449447002584	Protein of unknown function (DUF1092); Region: DUF1092; pfam06485
449447002585	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
449447002586	RimM N-terminal domain; Region: RimM; pfam01782
449447002587	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
449447002588	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447002589	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447002590	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447002591	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447002592	putative active site [active]
449447002593	Helix-turn-helix domains; Region: HTH; cl00088
449447002594	Integrase core domain; Region: rve; cl01316
449447002595	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
449447002596	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447002597	Helix-turn-helix domains; Region: HTH; cl00088
449447002598	Helix-turn-helix domains; Region: HTH; cl00088
449447002599	Integrase core domain; Region: rve; cl01316
449447002600	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
449447002601	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
449447002602	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
449447002603	catalytic residue [active]
449447002604	serine O-acetyltransferase; Region: cysE; TIGR01172
449447002605	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
449447002606	trimer interface [polypeptide binding]; other site
449447002607	active site
449447002608	substrate binding site [chemical binding]; other site
449447002609	CoA binding site [chemical binding]; other site
449447002610	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
449447002611	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
449447002612	dimer interface [polypeptide binding]; other site
449447002613	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447002614	catalytic residue [active]
449447002615	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447002616	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447002617	Probable transposase; Region: OrfB_IS605; pfam01385
449447002618	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447002619	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447002620	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447002621	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447002622	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447002623	Probable transposase; Region: OrfB_IS605; pfam01385
449447002624	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447002625	PemK-like protein; Region: PemK; cl00995
449447002626	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447002627	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447002628	NHL repeat; Region: NHL; pfam01436
449447002629	NHL repeat; Region: NHL; pfam01436
449447002630	NHL repeat; Region: NHL; pfam01436
449447002631	NHL repeat; Region: NHL; pfam01436
449447002632	NHL repeat; Region: NHL; pfam01436
449447002633	NHL repeat; Region: NHL; pfam01436
449447002634	putative transposase; Provisional; Region: PRK09857
449447002635	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447002636	Helix-turn-helix domains; Region: HTH; cl00088
449447002637	Integrase core domain; Region: rve; cl01316
449447002638	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447002639	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447002640	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447002641	dihydroorotase; Provisional; Region: PRK07369
449447002642	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
449447002643	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
449447002644	active site
449447002645	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
449447002646	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447002647	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447002648	putative active site [active]
449447002649	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
449447002650	RNA polymerase sigma factor; Validated; Region: PRK05949
449447002651	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
449447002652	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
449447002653	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
449447002654	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
449447002655	DNA binding residues [nucleotide binding]
449447002656	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
449447002657	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
449447002658	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
449447002659	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447002660	TPR repeat; Region: TPR_11; pfam13414
449447002661	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447002662	binding surface
449447002663	TPR motif; other site
449447002664	TPR repeat; Region: TPR_11; pfam13414
449447002665	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447002666	binding surface
449447002667	TPR motif; other site
449447002668	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447002669	binding surface
449447002670	TPR motif; other site
449447002671	TPR repeat; Region: TPR_11; pfam13414
449447002672	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
449447002673	PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388
449447002674	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447002675	TPR motif; other site
449447002676	binding surface
449447002677	TPR repeat; Region: TPR_11; pfam13414
449447002678	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447002679	binding surface
449447002680	TPR motif; other site
449447002681	Tetratricopeptide repeat; Region: TPR_16; pfam13432
449447002682	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
449447002683	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447002684	Walker A/P-loop; other site
449447002685	ATP binding site [chemical binding]; other site
449447002686	Q-loop/lid; other site
449447002687	ABC transporter signature motif; other site
449447002688	Walker B; other site
449447002689	D-loop; other site
449447002690	H-loop/switch region; other site
449447002691	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
449447002692	active site
449447002693	zinc binding site [ion binding]; other site
449447002694	translation initiation factor IF-2; Validated; Region: infB; PRK05306
449447002695	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
449447002696	translation initiation factor IF-2; Region: IF-2; TIGR00487
449447002697	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
449447002698	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
449447002699	G1 box; other site
449447002700	putative GEF interaction site [polypeptide binding]; other site
449447002701	GTP/Mg2+ binding site [chemical binding]; other site
449447002702	Switch I region; other site
449447002703	G2 box; other site
449447002704	G3 box; other site
449447002705	Switch II region; other site
449447002706	G4 box; other site
449447002707	G5 box; other site
449447002708	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
449447002709	Translation-initiation factor 2; Region: IF-2; pfam11987
449447002710	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
449447002711	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189
449447002712	putative RNA binding cleft [nucleotide binding]; other site
449447002713	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
449447002714	NusA N-terminal domain; Region: NusA_N; pfam08529
449447002715	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
449447002716	RNA binding site [nucleotide binding]; other site
449447002717	homodimer interface [polypeptide binding]; other site
449447002718	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
449447002719	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
449447002720	G-X-X-G motif; other site
449447002721	ribosome maturation protein RimP; Reviewed; Region: PRK00092
449447002722	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
449447002723	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
449447002724	Sm1 motif; other site
449447002725	D3 - B interaction site; other site
449447002726	D1 - D2 interaction site; other site
449447002727	Hfq - Hfq interaction site; other site
449447002728	RNA binding pocket [nucleotide binding]; other site
449447002729	Sm2 motif; other site
449447002730	cell division protein; Validated; Region: ftsH; CHL00176
449447002731	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447002732	Walker A motif; other site
449447002733	ATP binding site [chemical binding]; other site
449447002734	Walker B motif; other site
449447002735	arginine finger; other site
449447002736	Peptidase family M41; Region: Peptidase_M41; pfam01434
449447002737	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
449447002738	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447002739	active site
449447002740	phosphorylation site [posttranslational modification]
449447002741	intermolecular recognition site; other site
449447002742	dimerization interface [polypeptide binding]; other site
449447002743	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
449447002744	DNA binding site [nucleotide binding]
449447002745	Protein of unknown function (DUF3155); Region: DUF3155; pfam11352
449447002746	GAF domain; Region: GAF; cl15785
449447002747	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447002748	phosphorylation site [posttranslational modification]
449447002749	dimer interface [polypeptide binding]; other site
449447002750	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447002751	ATP binding site [chemical binding]; other site
449447002752	Mg2+ binding site [ion binding]; other site
449447002753	G-X-G motif; other site
449447002754	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447002755	Helix-turn-helix domains; Region: HTH; cl00088
449447002756	Integrase core domain; Region: rve; cl01316
449447002757	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
449447002758	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447002759	DRTGG domain; Region: DRTGG; cl12147
449447002760	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
449447002761	Glucan exporter ATP-binding protein.  In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor.  This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254
449447002762	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
449447002763	Walker A/P-loop; other site
449447002764	ATP binding site [chemical binding]; other site
449447002765	Q-loop/lid; other site
449447002766	ABC transporter signature motif; other site
449447002767	Walker B; other site
449447002768	D-loop; other site
449447002769	H-loop/switch region; other site
449447002770	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
449447002771	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
449447002772	homodimer interface [polypeptide binding]; other site
449447002773	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447002774	catalytic residue [active]
449447002775	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
449447002776	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447002777	active site
449447002778	ATP binding site [chemical binding]; other site
449447002779	substrate binding site [chemical binding]; other site
449447002780	activation loop (A-loop); other site
449447002781	CTP synthetase; Validated; Region: pyrG; PRK05380
449447002782	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
449447002783	Catalytic site [active]
449447002784	active site
449447002785	UTP binding site [chemical binding]; other site
449447002786	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
449447002787	active site
449447002788	putative oxyanion hole; other site
449447002789	catalytic triad [active]
449447002790	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
449447002791	catalytic loop [active]
449447002792	iron binding site [ion binding]; other site
449447002793	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
449447002794	active site
449447002795	catalytic residues [active]
449447002796	metal binding site [ion binding]; metal-binding site
449447002797	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
449447002798	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447002799	active site
449447002800	ATP binding site [chemical binding]; other site
449447002801	substrate binding site [chemical binding]; other site
449447002802	activation loop (A-loop); other site
449447002803	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
449447002804	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
449447002805	substrate binding pocket [chemical binding]; other site
449447002806	chain length determination region; other site
449447002807	substrate-Mg2+ binding site; other site
449447002808	catalytic residues [active]
449447002809	aspartate-rich region 1; other site
449447002810	active site lid residues [active]
449447002811	aspartate-rich region 2; other site
449447002812	Divergent PAP2 family; Region: DUF212; cl00855
449447002813	dihydrodipicolinate reductase; Provisional; Region: PRK00048
449447002814	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447002815	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
449447002816	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
449447002817	active site
449447002818	NTP binding site [chemical binding]; other site
449447002819	metal binding triad [ion binding]; metal-binding site
449447002820	antibiotic binding site [chemical binding]; other site
449447002821	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
449447002822	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
449447002823	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447002824	NAD(P) binding site [chemical binding]; other site
449447002825	active site
449447002826	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447002827	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
449447002828	Walker A/P-loop; other site
449447002829	ATP binding site [chemical binding]; other site
449447002830	Q-loop/lid; other site
449447002831	ABC transporter signature motif; other site
449447002832	Walker B; other site
449447002833	D-loop; other site
449447002834	H-loop/switch region; other site
449447002835	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
449447002836	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
449447002837	P-loop; other site
449447002838	Magnesium ion binding site [ion binding]; other site
449447002839	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447002840	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
449447002841	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
449447002842	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
449447002843	trimer interface [polypeptide binding]; other site
449447002844	active site
449447002845	UDP-GlcNAc binding site [chemical binding]; other site
449447002846	lipid binding site [chemical binding]; lipid-binding site
449447002847	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
449447002848	gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066
449447002849	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
449447002850	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
449447002851	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
449447002852	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447002853	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
449447002854	ThiS interaction site; other site
449447002855	putative active site [active]
449447002856	tetramer interface [polypeptide binding]; other site
449447002857	Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241
449447002858	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
449447002859	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
449447002860	Walker A/P-loop; other site
449447002861	ATP binding site [chemical binding]; other site
449447002862	Q-loop/lid; other site
449447002863	ABC transporter signature motif; other site
449447002864	Walker B; other site
449447002865	D-loop; other site
449447002866	H-loop/switch region; other site
449447002867	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
449447002868	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
449447002869	Walker A/P-loop; other site
449447002870	ATP binding site [chemical binding]; other site
449447002871	Q-loop/lid; other site
449447002872	ABC transporter signature motif; other site
449447002873	Walker B; other site
449447002874	D-loop; other site
449447002875	H-loop/switch region; other site
449447002876	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
449447002877	NMT1-like family; Region: NMT1_2; cl15260
449447002878	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
449447002879	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447002880	dimer interface [polypeptide binding]; other site
449447002881	conserved gate region; other site
449447002882	putative PBP binding loops; other site
449447002883	ABC-ATPase subunit interface; other site
449447002884	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
449447002885	NMT1-like family; Region: NMT1_2; cl15260
449447002886	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447002887	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
449447002888	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
449447002889	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
449447002890	catalytic residue [active]
449447002891	Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397
449447002892	putative active site [active]
449447002893	putative metal binding site [ion binding]; other site
449447002894	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
449447002895	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
449447002896	dimer interface [polypeptide binding]; other site
449447002897	ADP-ribose binding site [chemical binding]; other site
449447002898	active site
449447002899	nudix motif; other site
449447002900	metal binding site [ion binding]; metal-binding site
449447002901	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
449447002902	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
449447002903	GTP/Mg2+ binding site [chemical binding]; other site
449447002904	G4 box; other site
449447002905	G5 box; other site
449447002906	G1 box; other site
449447002907	Switch I region; other site
449447002908	G2 box; other site
449447002909	G3 box; other site
449447002910	Switch II region; other site
449447002911	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
449447002912	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447002913	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
449447002914	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447002915	active site
449447002916	phosphorylation site [posttranslational modification]
449447002917	intermolecular recognition site; other site
449447002918	dimerization interface [polypeptide binding]; other site
449447002919	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
449447002920	DNA binding site [nucleotide binding]
449447002921	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
449447002922	heme binding pocket [chemical binding]; other site
449447002923	heme ligand [chemical binding]; other site
449447002924	Phosphopantetheine attachment site; Region: PP-binding; cl09936
449447002925	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
449447002926	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
449447002927	dimer interface [polypeptide binding]; other site
449447002928	active site
449447002929	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
449447002930	transketolase; Region: PLN02790
449447002931	TPP-binding site [chemical binding]; other site
449447002932	dimer interface [polypeptide binding]; other site
449447002933	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
449447002934	PYR/PP interface [polypeptide binding]; other site
449447002935	dimer interface [polypeptide binding]; other site
449447002936	TPP binding site [chemical binding]; other site
449447002937	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
449447002938	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
449447002939	non-specific DNA binding site [nucleotide binding]; other site
449447002940	salt bridge; other site
449447002941	sequence-specific DNA binding site [nucleotide binding]; other site
449447002942	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447002943	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
449447002944	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
449447002945	Domain of unknown function DUF21; Region: DUF21; pfam01595
449447002946	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
449447002947	Transporter associated domain; Region: CorC_HlyC; cl08393
449447002948	MltA specific insert domain; Region: MltA; cl08398
449447002949	3D domain; Region: 3D; cl01439
449447002950	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
449447002951	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447002952	FeS/SAM binding site; other site
449447002953	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
449447002954	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447002955	putative active site [active]
449447002956	Helix-turn-helix domains; Region: HTH; cl00088
449447002957	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
449447002958	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
449447002959	putative dimerization interface [polypeptide binding]; other site
449447002960	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
449447002961	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
449447002962	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
449447002963	active site clefts [active]
449447002964	zinc binding site [ion binding]; other site
449447002965	dimer interface [polypeptide binding]; other site
449447002966	NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363
449447002967	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
449447002968	CO2 hydration protein (ChpXY); Region: ChpXY; cl10905
449447002969	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447002970	putative active site [active]
449447002971	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447002972	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
449447002973	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
449447002974	homodimer interface [polypeptide binding]; other site
449447002975	oligonucleotide binding site [chemical binding]; other site
449447002976	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
449447002977	RNA/DNA hybrid binding site [nucleotide binding]; other site
449447002978	active site
449447002979	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447002980	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
449447002981	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
449447002982	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
449447002983	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447002984	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
449447002985	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447002986	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
449447002987	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447002988	structural tetrad; other site
449447002989	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447002990	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447002991	Transposase [DNA replication, recombination, and repair]; Region: COG5433
449447002992	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
449447002993	catalytic triad [active]
449447002994	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447002995	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447002996	Probable transposase; Region: OrfB_IS605; pfam01385
449447002997	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447002998	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
449447002999	3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356
449447003000	hinge; other site
449447003001	active site
449447003002	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
449447003003	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
449447003004	Walker A/P-loop; other site
449447003005	ATP binding site [chemical binding]; other site
449447003006	Q-loop/lid; other site
449447003007	ABC transporter signature motif; other site
449447003008	Walker B; other site
449447003009	D-loop; other site
449447003010	H-loop/switch region; other site
449447003011	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
449447003012	Walker A/P-loop; other site
449447003013	ATP binding site [chemical binding]; other site
449447003014	Q-loop/lid; other site
449447003015	ABC transporter signature motif; other site
449447003016	Walker B; other site
449447003017	D-loop; other site
449447003018	H-loop/switch region; other site
449447003019	amidophosphoribosyltransferase; Provisional; Region: PRK07349
449447003020	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
449447003021	active site
449447003022	tetramer interface [polypeptide binding]; other site
449447003023	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
449447003024	active site
449447003025	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
449447003026	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
449447003027	dimerization interface [polypeptide binding]; other site
449447003028	ATP binding site [chemical binding]; other site
449447003029	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
449447003030	dimerization interface [polypeptide binding]; other site
449447003031	ATP binding site [chemical binding]; other site
449447003032	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
449447003033	YcfA-like protein; Region: YcfA; cl00752
449447003034	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447003035	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447003036	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
449447003037	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
449447003038	Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783
449447003039	Integrase core domain; Region: rve; cl01316
449447003040	Helix-turn-helix domains; Region: HTH; cl00088
449447003041	Winged helix-turn helix; Region: HTH_29; pfam13551
449447003042	Helix-turn-helix domains; Region: HTH; cl00088
449447003043	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
449447003044	Transposase; Region: DEDD_Tnp_IS110; pfam01548
449447003045	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
449447003046	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
449447003047	Uncharacterized conserved protein [Function unknown]; Region: COG1262
449447003048	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
449447003049	Protein of unknown function (DUF3386); Region: DUF3386; pfam11866
449447003050	NifU-like domain; Region: NifU; cl00484
449447003051	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
449447003052	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447003053	Circadian oscillating protein COP23; Region: COP23; pfam14218
449447003054	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
449447003055	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
449447003056	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
449447003057	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447003058	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
449447003059	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
449447003060	acetylornithine aminotransferase; Provisional; Region: PRK02627
449447003061	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
449447003062	inhibitor-cofactor binding pocket; inhibition site
449447003063	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447003064	catalytic residue [active]
449447003065	Ion channel; Region: Ion_trans_2; cl11596
449447003066	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
449447003067	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447003068	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
449447003069	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447003070	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447003071	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447003072	Probable transposase; Region: OrfB_IS605; pfam01385
449447003073	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447003074	pilus retraction protein PilT; Region: pilT_fam; TIGR01420
449447003075	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
449447003076	Walker A motif; other site
449447003077	ATP binding site [chemical binding]; other site
449447003078	Walker B motif; other site
449447003079	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
449447003080	tetramer interface [polypeptide binding]; other site
449447003081	dimer interface [polypeptide binding]; other site
449447003082	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_8; cd06905
449447003083	putative active site [active]
449447003084	Zn binding site [ion binding]; other site
449447003085	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
449447003086	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
449447003087	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447003088	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
449447003089	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447003090	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
449447003091	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447003092	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447003093	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447003094	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447003095	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447003096	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447003097	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
449447003098	C-terminal domain interface [polypeptide binding]; other site
449447003099	GSH binding site (G-site) [chemical binding]; other site
449447003100	dimer interface [polypeptide binding]; other site
449447003101	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
449447003102	N-terminal domain interface [polypeptide binding]; other site
449447003103	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
449447003104	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447003105	active site
449447003106	phosphorylation site [posttranslational modification]
449447003107	intermolecular recognition site; other site
449447003108	dimerization interface [polypeptide binding]; other site
449447003109	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
449447003110	DNA binding site [nucleotide binding]
449447003111	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
449447003112	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
449447003113	active site
449447003114	molecular chaperone DnaK; Provisional; Region: PRK13410
449447003115	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
449447003116	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
449447003117	HSP70 interaction site [polypeptide binding]; other site
449447003118	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
449447003119	dimer interface [polypeptide binding]; other site
449447003120	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
449447003121	Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167
449447003122	active site
449447003123	catalytic residues [active]
449447003124	FMN binding site [chemical binding]; other site
449447003125	quinone interaction residues [chemical binding]; other site
449447003126	substrate binding site [chemical binding]; other site
449447003127	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
449447003128	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
449447003129	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
449447003130	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
449447003131	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895
449447003132	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
449447003133	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447003134	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447003135	Probable transposase; Region: OrfB_IS605; pfam01385
449447003136	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447003137	XisH protein; Region: XisH; pfam08814
449447003138	XisI protein; Region: XisI; pfam08869
449447003139	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447003140	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447003141	Transposase [DNA replication, recombination, and repair]; Region: COG5433
449447003142	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
449447003143	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
449447003144	active site
449447003145	catalytic tetrad [active]
449447003146	recombinase A; Provisional; Region: recA; PRK09354
449447003147	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
449447003148	hexamer interface [polypeptide binding]; other site
449447003149	Walker A motif; other site
449447003150	ATP binding site [chemical binding]; other site
449447003151	Walker B motif; other site
449447003152	NlpC/P60 family; Region: NLPC_P60; cl11438
449447003153	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
449447003154	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
449447003155	N-acetyl-D-glucosamine binding site [chemical binding]; other site
449447003156	catalytic residue [active]
449447003157	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
449447003158	Domain of unknown function (DUF1817); Region: DUF1817; cl02292
449447003159	LytB protein; Region: LYTB; cl00507
449447003160	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
449447003161	photochlorophyllide reductase subunit L; Region: chlL; CHL00072
449447003162	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
449447003163	P-loop; other site
449447003164	Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
449447003165	Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979
449447003166	AAA domain; Region: AAA_21; pfam13304
449447003167	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447003168	ABC transporter signature motif; other site
449447003169	Walker B; other site
449447003170	D-loop; other site
449447003171	H-loop/switch region; other site
449447003172	RloB-like protein; Region: RloB; pfam13707
449447003173	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
449447003174	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
449447003175	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447003176	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447003177	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447003178	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
449447003179	CHAT domain; Region: CHAT; pfam12770
449447003180	YcfA-like protein; Region: YcfA; cl00752
449447003181	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
449447003182	non-specific DNA binding site [nucleotide binding]; other site
449447003183	salt bridge; other site
449447003184	sequence-specific DNA binding site [nucleotide binding]; other site
449447003185	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
449447003186	YcfA-like protein; Region: YcfA; cl00752
449447003187	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
449447003188	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
449447003189	putative active site [active]
449447003190	Predicted transcriptional regulator [Transcription]; Region: COG4190
449447003191	YcfA-like protein; Region: YcfA; cl00752
449447003192	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
449447003193	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447003194	Helix-turn-helix domains; Region: HTH; cl00088
449447003195	Helix-turn-helix domains; Region: HTH; cl00088
449447003196	Winged helix-turn helix; Region: HTH_29; pfam13551
449447003197	Winged helix-turn helix; Region: HTH_33; pfam13592
449447003198	Integrase core domain; Region: rve; cl01316
449447003199	Helix-turn-helix domains; Region: HTH; cl00088
449447003200	Winged helix-turn helix; Region: HTH_29; pfam13551
449447003201	Winged helix-turn helix; Region: HTH_33; pfam13592
449447003202	Integrase core domain; Region: rve; cl01316
449447003203	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447003204	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447003205	Probable transposase; Region: OrfB_IS605; pfam01385
449447003206	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447003207	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
449447003208	FMN binding site [chemical binding]; other site
449447003209	active site
449447003210	catalytic residues [active]
449447003211	substrate binding site [chemical binding]; other site
449447003212	Helix-turn-helix domains; Region: HTH; cl00088
449447003213	Winged helix-turn helix; Region: HTH_29; pfam13551
449447003214	Winged helix-turn helix; Region: HTH_33; pfam13592
449447003215	Integrase core domain; Region: rve; cl01316
449447003216	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
449447003217	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096
449447003218	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
449447003219	active site
449447003220	dimer interface [polypeptide binding]; other site
449447003221	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
449447003222	dimer interface [polypeptide binding]; other site
449447003223	active site
449447003224	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
449447003225	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
449447003226	FtsX-like permease family; Region: FtsX; cl15850
449447003227	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
449447003228	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447003229	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
449447003230	histidinol dehydrogenase; Region: hisD; TIGR00069
449447003231	NAD binding site [chemical binding]; other site
449447003232	dimerization interface [polypeptide binding]; other site
449447003233	product binding site; other site
449447003234	substrate binding site [chemical binding]; other site
449447003235	zinc binding site [ion binding]; other site
449447003236	catalytic residues [active]
449447003237	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
449447003238	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
449447003239	ATP-grasp domain; Region: ATP-grasp_4; cl03087
449447003240	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
449447003241	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447003242	putative active site [active]
449447003243	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447003244	putative active site [active]
449447003245	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447003246	putative active site [active]
449447003247	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447003248	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447003249	putative active site [active]
449447003250	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
449447003251	competence damage-inducible protein A; Provisional; Region: PRK00549
449447003252	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
449447003253	putative MPT binding site; other site
449447003254	Competence-damaged protein; Region: CinA; cl00666
449447003255	large terminase protein; Provisional; Region: 17; PHA02533
449447003256	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447003257	Transposase IS200 like; Region: Y1_Tnp; cl00848
449447003258	Probable transposase; Region: OrfB_IS605; pfam01385
449447003259	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447003260	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
449447003261	Taspase1_like domains; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A...; Region: Taspase1_like; cd04514
449447003262	active site
449447003263	dimer interface [polypeptide binding]; other site
449447003264	catalytic nucleophile [active]
449447003265	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
449447003266	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
449447003267	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447003268	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447003269	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
449447003270	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
449447003271	homoserine kinase; Provisional; Region: PRK01212
449447003272	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
449447003273	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
449447003274	Helix-turn-helix domains; Region: HTH; cl00088
449447003275	Winged helix-turn helix; Region: HTH_29; pfam13551
449447003276	Winged helix-turn helix; Region: HTH_33; pfam13592
449447003277	Integrase core domain; Region: rve; cl01316
449447003278	Winged helix-turn helix; Region: HTH_33; pfam13592
449447003279	Integrase core domain; Region: rve; cl01316
449447003280	Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042
449447003281	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
449447003282	MoaE interaction surface [polypeptide binding]; other site
449447003283	MoeB interaction surface [polypeptide binding]; other site
449447003284	thiocarboxylated glycine; other site
449447003285	threonine synthase; Validated; Region: PRK07591
449447003286	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
449447003287	homodimer interface [polypeptide binding]; other site
449447003288	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447003289	catalytic residue [active]
449447003290	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447003291	S-adenosylmethionine binding site [chemical binding]; other site
449447003292	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
449447003293	active site
449447003294	Fe-S cluster binding site [ion binding]; other site
449447003295	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
449447003296	GTPase Era; Reviewed; Region: era; PRK00089
449447003297	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
449447003298	G1 box; other site
449447003299	GTP/Mg2+ binding site [chemical binding]; other site
449447003300	Switch I region; other site
449447003301	G2 box; other site
449447003302	Switch II region; other site
449447003303	G3 box; other site
449447003304	G4 box; other site
449447003305	G5 box; other site
449447003306	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
449447003307	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
449447003308	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447003309	active site
449447003310	ATP binding site [chemical binding]; other site
449447003311	substrate binding site [chemical binding]; other site
449447003312	activation loop (A-loop); other site
449447003313	Transposase IS200 like; Region: Y1_Tnp; cl00848
449447003314	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447003315	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447003316	Probable transposase; Region: OrfB_IS605; pfam01385
449447003317	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447003318	CbiD; Region: CbiD; cl00828
449447003319	GMP synthase; Reviewed; Region: guaA; PRK00074
449447003320	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
449447003321	AMP/PPi binding site [chemical binding]; other site
449447003322	candidate oxyanion hole; other site
449447003323	catalytic triad [active]
449447003324	potential glutamine specificity residues [chemical binding]; other site
449447003325	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
449447003326	ATP Binding subdomain [chemical binding]; other site
449447003327	Ligand Binding sites [chemical binding]; other site
449447003328	Dimerization subdomain; other site
449447003329	Protein of unknown function DUF262; Region: DUF262; cl14890
449447003330	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
449447003331	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
449447003332	cofactor binding site; other site
449447003333	DNA binding site [nucleotide binding]
449447003334	substrate interaction site [chemical binding]; other site
449447003335	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
449447003336	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
449447003337	active site
449447003338	catalytic residues [active]
449447003339	calcium/proton exchanger (cax); Region: cax; TIGR00378
449447003340	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
449447003341	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
449447003342	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
449447003343	Protein of unknown function DUF262; Region: DUF262; cl14890
449447003344	sulfite reductase subunit beta; Provisional; Region: PRK13504
449447003345	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
449447003346	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
449447003347	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
449447003348	phosphopeptide binding site; other site
449447003349	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
449447003350	phosphopeptide binding site; other site
449447003351	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
449447003352	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447003353	Walker A/P-loop; other site
449447003354	ATP binding site [chemical binding]; other site
449447003355	Q-loop/lid; other site
449447003356	ABC transporter signature motif; other site
449447003357	Walker B; other site
449447003358	D-loop; other site
449447003359	H-loop/switch region; other site
449447003360	ABC-2 type transporter; Region: ABC2_membrane; cl11417
449447003361	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
449447003362	von Willebrand factor type D domain; Region: VWD; cl02516
449447003363	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
449447003364	Calx-beta domain; Region: Calx-beta; cl02522
449447003365	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
449447003366	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
449447003367	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447003368	AAA domain; Region: AAA_21; pfam13304
449447003369	Walker A/P-loop; other site
449447003370	ATP binding site [chemical binding]; other site
449447003371	Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042
449447003372	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
449447003373	ATP-sulfurylase; Region: ATPS; cd00517
449447003374	active site
449447003375	HXXH motif; other site
449447003376	flexible loop; other site
449447003377	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
449447003378	classical (c) SDRs; Region: SDR_c; cd05233
449447003379	NAD(P) binding site [chemical binding]; other site
449447003380	active site
449447003381	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
449447003382	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
449447003383	dimer interface [polypeptide binding]; other site
449447003384	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
449447003385	active site
449447003386	Fe binding site [ion binding]; other site
449447003387	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
449447003388	catalytic motif [active]
449447003389	Catalytic residue [active]
449447003390	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
449447003391	nucleotide binding site/active site [active]
449447003392	HIT family signature motif; other site
449447003393	catalytic residue [active]
449447003394	Mg chelatase-related protein; Region: TIGR00368
449447003395	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
449447003396	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447003397	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
449447003398	AAA domain; Region: AAA_21; pfam13304
449447003399	ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules.  The...; Region: ABC_ATPase; cd00267
449447003400	Walker B; other site
449447003401	D-loop; other site
449447003402	H-loop/switch region; other site
449447003403	PseudoU_synth:  Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families.  This group consists of...; Region: PseudoU_synth; cl00130
449447003404	pseudouridine synthase; Region: TIGR00093
449447003405	active site
449447003406	ABC-2 type transporter; Region: ABC2_membrane; cl11417
449447003407	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447003408	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
449447003409	active site
449447003410	substrate binding site [chemical binding]; other site
449447003411	ATP binding site [chemical binding]; other site
449447003412	activation loop (A-loop); other site
449447003413	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447003414	structural tetrad; other site
449447003415	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270
449447003416	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
449447003417	putative active site [active]
449447003418	Protein of unknown function (DUF433); Region: DUF433; cl01030
449447003419	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
449447003420	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447003421	active site
449447003422	phosphorylation site [posttranslational modification]
449447003423	intermolecular recognition site; other site
449447003424	dimerization interface [polypeptide binding]; other site
449447003425	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
449447003426	DNA binding residues [nucleotide binding]
449447003427	dimerization interface [polypeptide binding]; other site
449447003428	phosphoenolpyruvate synthase; Region: PEP_synth; TIGR01418
449447003429	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
449447003430	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
449447003431	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
449447003432	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
449447003433	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
449447003434	phosphoenolpyruvate synthase; Validated; Region: PRK06241
449447003435	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
449447003436	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447003437	putative active site [active]
449447003438	transcriptional regulator EutR; Provisional; Region: PRK10130
449447003439	HupE / UreJ protein; Region: HupE_UreJ; cl01011
449447003440	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
449447003441	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447003442	Methyltransferase domain; Region: Methyltransf_31; pfam13847
449447003443	S-adenosylmethionine binding site [chemical binding]; other site
449447003444	Domain of unknown function DUF39; Region: DUF39; cl14897
449447003445	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
449447003446	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
449447003447	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447003448	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447003449	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447003450	Probable transposase; Region: OrfB_IS605; pfam01385
449447003451	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447003452	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
449447003453	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447003454	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
449447003455	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
449447003456	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
449447003457	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
449447003458	active site
449447003459	metal binding site [ion binding]; metal-binding site
449447003460	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
449447003461	putative ADP-binding pocket [chemical binding]; other site
449447003462	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447003463	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
449447003464	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
449447003465	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447003466	catalytic residue [active]
449447003467	Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449
449447003468	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
449447003469	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
449447003470	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
449447003471	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
449447003472	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
449447003473	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
449447003474	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
449447003475	putative sugar binding sites [chemical binding]; other site
449447003476	Q-X-W motif; other site
449447003477	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
449447003478	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
449447003479	YcfA-like protein; Region: YcfA; cl00752
449447003480	Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651
449447003481	Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651
449447003482	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447003483	D2 subunit  of photosystem II (PS II); Region: Photosystem-II_D2; cd09288
449447003484	D1 interface; other site
449447003485	chlorophyll binding site; other site
449447003486	pheophytin binding site; other site
449447003487	beta carotene binding site; other site
449447003488	cytochrome b559 beta interface; other site
449447003489	quinone binding site; other site
449447003490	cytochrome b559 alpha interface; other site
449447003491	protein J interface; other site
449447003492	protein H interface; other site
449447003493	protein X interface; other site
449447003494	core light harvesting protein interface; other site
449447003495	protein L interface; other site
449447003496	CP43 interface; other site
449447003497	protein T interface; other site
449447003498	Fe binding site [ion binding]; other site
449447003499	protein M interface; other site
449447003500	Mn-stabilizing polypeptide interface; other site
449447003501	bromide binding site; other site
449447003502	cytochrome c-550 interface; other site
449447003503	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
449447003504	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447003505	CAAX protease self-immunity; Region: Abi; cl00558
449447003506	Transposase [DNA replication, recombination, and repair]; Region: COG5433
449447003507	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447003508	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447003509	Transposase domain (DUF772); Region: DUF772; cl15789
449447003510	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
449447003511	metal-binding site [ion binding]
449447003512	DNA polymerase I; Provisional; Region: PRK05755
449447003513	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
449447003514	active site
449447003515	metal binding site 1 [ion binding]; metal-binding site
449447003516	putative 5' ssDNA interaction site; other site
449447003517	metal binding site 3; metal-binding site
449447003518	metal binding site 2 [ion binding]; metal-binding site
449447003519	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
449447003520	putative DNA binding site [nucleotide binding]; other site
449447003521	putative metal binding site [ion binding]; other site
449447003522	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
449447003523	active site
449447003524	catalytic site [active]
449447003525	substrate binding site [chemical binding]; other site
449447003526	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
449447003527	active site
449447003528	DNA binding site [nucleotide binding]
449447003529	catalytic site [active]
449447003530	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447003531	putative active site [active]
449447003532	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
449447003533	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
449447003534	NAD binding site [chemical binding]; other site
449447003535	putative substrate binding site 2 [chemical binding]; other site
449447003536	putative substrate binding site 1 [chemical binding]; other site
449447003537	active site
449447003538	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
449447003539	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447003540	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
449447003541	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447003542	tellurium resistance terB-like protein; Region: terB_like; cd07177
449447003543	metal binding site [ion binding]; metal-binding site
449447003544	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
449447003545	Sulfate transporter family; Region: Sulfate_transp; cl15842
449447003546	high affinity sulphate transporter 1; Region: sulP; TIGR00815
449447003547	Sulfate transporter family; Region: Sulfate_transp; cl15842
449447003548	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
449447003549	Protein of unknown function (DUF433); Region: DUF433; cl01030
449447003550	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447003551	putative active site [active]
449447003552	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447003553	putative active site [active]
449447003554	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
449447003555	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
449447003556	homodimer interface [polypeptide binding]; other site
449447003557	Walker A motif; other site
449447003558	ATP binding site [chemical binding]; other site
449447003559	hydroxycobalamin binding site [chemical binding]; other site
449447003560	Walker B motif; other site
449447003561	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
449447003562	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
449447003563	active site
449447003564	catalytic tetrad [active]
449447003565	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
449447003566	active site
449447003567	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
449447003568	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
449447003569	Walker A/P-loop; other site
449447003570	ATP binding site [chemical binding]; other site
449447003571	Q-loop/lid; other site
449447003572	ABC transporter signature motif; other site
449447003573	Walker B; other site
449447003574	D-loop; other site
449447003575	H-loop/switch region; other site
449447003576	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447003577	dimer interface [polypeptide binding]; other site
449447003578	conserved gate region; other site
449447003579	putative PBP binding loops; other site
449447003580	ABC-ATPase subunit interface; other site
449447003581	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
449447003582	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
449447003583	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
449447003584	phosphate transporter ATP-binding protein; Provisional; Region: PRK14243
449447003585	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
449447003586	Walker A/P-loop; other site
449447003587	ATP binding site [chemical binding]; other site
449447003588	Q-loop/lid; other site
449447003589	ABC transporter signature motif; other site
449447003590	Walker B; other site
449447003591	D-loop; other site
449447003592	H-loop/switch region; other site
449447003593	phosphate transporter ATP-binding protein; Provisional; Region: PRK14243
449447003594	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
449447003595	Walker A/P-loop; other site
449447003596	ATP binding site [chemical binding]; other site
449447003597	Q-loop/lid; other site
449447003598	ABC transporter signature motif; other site
449447003599	Walker B; other site
449447003600	D-loop; other site
449447003601	H-loop/switch region; other site
449447003602	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
449447003603	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447003604	dimer interface [polypeptide binding]; other site
449447003605	conserved gate region; other site
449447003606	putative PBP binding loops; other site
449447003607	ABC-ATPase subunit interface; other site
449447003608	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447003609	dimer interface [polypeptide binding]; other site
449447003610	conserved gate region; other site
449447003611	putative PBP binding loops; other site
449447003612	ABC-ATPase subunit interface; other site
449447003613	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
449447003614	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
449447003615	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566
449447003616	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
449447003617	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
449447003618	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
449447003619	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
449447003620	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
449447003621	non-specific DNA interactions [nucleotide binding]; other site
449447003622	DNA binding site [nucleotide binding]
449447003623	sequence specific DNA binding site [nucleotide binding]; other site
449447003624	putative cAMP binding site [chemical binding]; other site
449447003625	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
449447003626	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
449447003627	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447003628	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447003629	Phosphotransferase enzyme family; Region: APH; pfam01636
449447003630	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
449447003631	active site
449447003632	ATP binding site [chemical binding]; other site
449447003633	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
449447003634	dimer interface [polypeptide binding]; other site
449447003635	catalytic triad [active]
449447003636	Haemolysin XhlA; Region: XhlA; pfam10779
449447003637	FOG: CBS domain [General function prediction only]; Region: COG0517
449447003638	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
449447003639	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447003640	putative active site [active]
449447003641	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428
449447003642	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
449447003643	dimerization interface [polypeptide binding]; other site
449447003644	active site
449447003645	Uncharacterized conserved protein [Function unknown]; Region: COG1912
449447003646	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
449447003647	Predicted acetyltransferase [General function prediction only]; Region: COG3393
449447003648	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
449447003649	Coenzyme A binding pocket [chemical binding]; other site
449447003650	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
449447003651	active site
449447003652	Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385
449447003653	Stage II sporulation protein; Region: SpoIID; pfam08486
449447003654	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
449447003655	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447003656	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
449447003657	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
449447003658	Cation transport protein; Region: TrkH; cl10514
449447003659	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447003660	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
449447003661	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; cl01792
449447003662	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
449447003663	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
449447003664	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
449447003665	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
449447003666	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447003667	putative active site [active]
449447003668	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
449447003669	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
449447003670	P-loop; other site
449447003671	Magnesium ion binding site [ion binding]; other site
449447003672	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
449447003673	Magnesium ion binding site [ion binding]; other site
449447003674	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
449447003675	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
449447003676	anthranilate synthase component I-like protein; Validated; Region: PRK05940
449447003677	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
449447003678	chorismate binding enzyme; Region: Chorismate_bind; cl10555
449447003679	Predicted permease; Region: DUF318; pfam03773
449447003680	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
449447003681	Arginase family; Region: Arginase; cl00306
449447003682	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
449447003683	hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418
449447003684	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447003685	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447003686	G4 box; other site
449447003687	G5 box; other site
449447003688	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
449447003689	NMT1-like family; Region: NMT1_2; cl15260
449447003690	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
449447003691	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
449447003692	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
449447003693	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
449447003694	Walker A/P-loop; other site
449447003695	ATP binding site [chemical binding]; other site
449447003696	Q-loop/lid; other site
449447003697	ABC transporter signature motif; other site
449447003698	Walker B; other site
449447003699	D-loop; other site
449447003700	H-loop/switch region; other site
449447003701	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
449447003702	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
449447003703	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
449447003704	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447003705	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
449447003706	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
449447003707	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
449447003708	anticodon binding site; other site
449447003709	tRNA binding surface [nucleotide binding]; other site
449447003710	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
449447003711	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
449447003712	large terminase protein; Provisional; Region: 17; PHA02533
449447003713	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447003714	putative active site [active]
449447003715	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447003716	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
449447003717	putative ADP-binding pocket [chemical binding]; other site
449447003718	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
449447003719	Tetramer interface [polypeptide binding]; other site
449447003720	active site
449447003721	FMN-binding site [chemical binding]; other site
449447003722	Sugar fermentation stimulation protein; Region: SfsA; cl00647
449447003723	YacP-like NYN domain; Region: NYN_YacP; cl01491
449447003724	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
449447003725	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
449447003726	Walker A/P-loop; other site
449447003727	ATP binding site [chemical binding]; other site
449447003728	Q-loop/lid; other site
449447003729	ABC transporter signature motif; other site
449447003730	Walker B; other site
449447003731	D-loop; other site
449447003732	H-loop/switch region; other site
449447003733	hypothetical protein; Provisional; Region: PRK13683
449447003734	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447003735	S-adenosylmethionine binding site [chemical binding]; other site
449447003736	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447003737	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447003738	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
449447003739	cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474
449447003740	Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802
449447003741	Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471
449447003742	cytochrome b subunit interaction site [polypeptide binding]; other site
449447003743	[2Fe-2S] cluster binding site [ion binding]; other site
449447003744	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
449447003745	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
449447003746	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
449447003747	Substrate binding site; other site
449447003748	Cupin domain; Region: Cupin_2; cl09118
449447003749	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
449447003750	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
449447003751	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
449447003752	active site
449447003753	ATP binding site [chemical binding]; other site
449447003754	glutamine synthetase, type I; Region: GlnA; TIGR00653
449447003755	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
449447003756	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
449447003757	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
449447003758	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
449447003759	tandem repeat interface [polypeptide binding]; other site
449447003760	oligomer interface [polypeptide binding]; other site
449447003761	active site residues [active]
449447003762	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
449447003763	homotrimer interaction site [polypeptide binding]; other site
449447003764	active site
449447003765	hydrolase, alpha/beta fold family protein; Region: PLN02679
449447003766	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
449447003767	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
449447003768	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
449447003769	Peptidase family M48; Region: Peptidase_M48; cl12018
449447003770	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447003771	Probable transposase; Region: OrfB_IS605; pfam01385
449447003772	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447003773	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
449447003774	Helix-turn-helix domains; Region: HTH; cl00088
449447003775	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
449447003776	putative dimerization interface [polypeptide binding]; other site
449447003777	Domain of unknown function (DUF955); Region: DUF955; cl01076
449447003778	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
449447003779	non-specific DNA binding site [nucleotide binding]; other site
449447003780	salt bridge; other site
449447003781	sequence-specific DNA binding site [nucleotide binding]; other site
449447003782	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
449447003783	Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628
449447003784	5' RNA guide strand anchoring site; other site
449447003785	active site
449447003786	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
449447003787	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
449447003788	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
449447003789	active site
449447003790	catalytic site [active]
449447003791	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
449447003792	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447003793	Acyl transferase domain; Region: Acyl_transf_1; cl08282
449447003794	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
449447003795	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
449447003796	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
449447003797	dimer interface [polypeptide binding]; other site
449447003798	active site
449447003799	CoA binding pocket [chemical binding]; other site
449447003800	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
449447003801	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
449447003802	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
449447003803	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
449447003804	Protein of unknown function (DUF497); Region: DUF497; cl01108
449447003805	Protein of unknown function (DUF3680); Region: DUF3680; cl02189
449447003806	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
449447003807	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447003808	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
449447003809	Protein of unknown function (DUF3146); Region: DUF3146; pfam11344
449447003810	Domain of unknown function (DUF389); Region: DUF389; cl00781
449447003811	Probable transposase; Region: OrfB_IS605; pfam01385
449447003812	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447003813	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
449447003814	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
449447003815	5S rRNA interface [nucleotide binding]; other site
449447003816	CTC domain interface [polypeptide binding]; other site
449447003817	L16 interface [polypeptide binding]; other site
449447003818	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
449447003819	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
449447003820	GDP-binding site [chemical binding]; other site
449447003821	ACT binding site; other site
449447003822	IMP binding site; other site
449447003823	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
449447003824	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
449447003825	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
449447003826	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
449447003827	active site
449447003828	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
449447003829	chaperone protein DnaJ; Provisional; Region: PRK14299
449447003830	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
449447003831	HSP70 interaction site [polypeptide binding]; other site
449447003832	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
449447003833	substrate binding site [polypeptide binding]; other site
449447003834	dimer interface [polypeptide binding]; other site
449447003835	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
449447003836	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447003837	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447003838	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447003839	secreted effector protein PipB; Provisional; Region: PRK15197
449447003840	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
449447003841	MASE1; Region: MASE1; pfam05231
449447003842	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
449447003843	GAF domain; Region: GAF; cl15785
449447003844	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447003845	dimer interface [polypeptide binding]; other site
449447003846	phosphorylation site [posttranslational modification]
449447003847	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447003848	ATP binding site [chemical binding]; other site
449447003849	Mg2+ binding site [ion binding]; other site
449447003850	G-X-G motif; other site
449447003851	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
449447003852	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447003853	active site
449447003854	phosphorylation site [posttranslational modification]
449447003855	intermolecular recognition site; other site
449447003856	dimerization interface [polypeptide binding]; other site
449447003857	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
449447003858	DNA binding residues [nucleotide binding]
449447003859	dimerization interface [polypeptide binding]; other site
449447003860	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
449447003861	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447003862	putative active site [active]
449447003863	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447003864	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
449447003865	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447003866	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447003867	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447003868	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
449447003869	dinuclear metal binding motif [ion binding]; other site
449447003870	Helix-turn-helix domains; Region: HTH; cl00088
449447003871	Winged helix-turn helix; Region: HTH_29; pfam13551
449447003872	Helix-turn-helix domains; Region: HTH; cl00088
449447003873	Integrase core domain; Region: rve; cl01316
449447003874	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
449447003875	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
449447003876	argininosuccinate lyase; Provisional; Region: PRK00855
449447003877	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
449447003878	active sites [active]
449447003879	tetramer interface [polypeptide binding]; other site
449447003880	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
449447003881	nudix motif; other site
449447003882	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
449447003883	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
449447003884	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
449447003885	active site
449447003886	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
449447003887	Small T antigen; Reviewed; Region: PHA03102
449447003888	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
449447003889	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
449447003890	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
449447003891	putative active site [active]
449447003892	putative NTP binding site [chemical binding]; other site
449447003893	putative nucleic acid binding site [nucleotide binding]; other site
449447003894	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
449447003895	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
449447003896	active site
449447003897	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
449447003898	NMT1-like family; Region: NMT1_2; cl15260
449447003899	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
449447003900	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
449447003901	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
449447003902	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
449447003903	Walker A/P-loop; other site
449447003904	ATP binding site [chemical binding]; other site
449447003905	Q-loop/lid; other site
449447003906	ABC transporter signature motif; other site
449447003907	Walker B; other site
449447003908	D-loop; other site
449447003909	H-loop/switch region; other site
449447003910	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
449447003911	NMT1-like family; Region: NMT1_2; cl15260
449447003912	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
449447003913	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
449447003914	Walker A/P-loop; other site
449447003915	ATP binding site [chemical binding]; other site
449447003916	Q-loop/lid; other site
449447003917	ABC transporter signature motif; other site
449447003918	Walker B; other site
449447003919	D-loop; other site
449447003920	H-loop/switch region; other site
449447003921	Phosphate-starvation-inducible E; Region: PsiE; cl01264
449447003922	Bacterial SH3 domain; Region: SH3_3; cl02551
449447003923	Ycf46; Provisional; Region: ycf46; CHL00195
449447003924	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447003925	Walker A motif; other site
449447003926	ATP binding site [chemical binding]; other site
449447003927	Walker B motif; other site
449447003928	arginine finger; other site
449447003929	Cupin domain; Region: Cupin_2; cl09118
449447003930	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
449447003931	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
449447003932	inhibitor-cofactor binding pocket; inhibition site
449447003933	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447003934	catalytic residue [active]
449447003935	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
449447003936	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
449447003937	Ligand binding site; other site
449447003938	Putative Catalytic site; other site
449447003939	DXD motif; other site
449447003940	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
449447003941	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
449447003942	Protein of unknown function (DUF3493); Region: DUF3493; pfam11998
449447003943	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
449447003944	homodimer interface [polypeptide binding]; other site
449447003945	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
449447003946	active site pocket [active]
449447003947	Protein of unknown function (DUF1349); Region: DUF1349; cl01397
449447003948	XisH protein; Region: XisH; pfam08814
449447003949	XisI protein; Region: XisI; pfam08869
449447003950	Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136
449447003951	Helix-turn-helix domains; Region: HTH; cl00088
449447003952	Winged helix-turn helix; Region: HTH_29; pfam13551
449447003953	Helix-turn-helix domains; Region: HTH; cl00088
449447003954	Integrase core domain; Region: rve; cl01316
449447003955	Uncharacterized conserved protein [Function unknown]; Region: COG1432
449447003956	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
449447003957	putative metal binding site [ion binding]; other site
449447003958	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
449447003959	Helix-turn-helix domains; Region: HTH; cl00088
449447003960	Helix-turn-helix domains; Region: HTH; cl00088
449447003961	Integrase core domain; Region: rve; cl01316
449447003962	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447003963	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
449447003964	HSP70 interaction site [polypeptide binding]; other site
449447003965	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
449447003966	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447003967	active site
449447003968	ATP binding site [chemical binding]; other site
449447003969	substrate binding site [chemical binding]; other site
449447003970	activation loop (A-loop); other site
449447003971	Probable transposase; Region: OrfB_IS605; pfam01385
449447003972	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447003973	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447003974	putative active site [active]
449447003975	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447003976	Putative addiction module component; Region: Unstab_antitox; cl09921
449447003977	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447003978	Helix-turn-helix domains; Region: HTH; cl00088
449447003979	Integrase core domain; Region: rve; cl01316
449447003980	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
449447003981	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447003982	putative active site [active]
449447003983	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447003984	putative active site [active]
449447003985	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
449447003986	ABC-2 type transporter; Region: ABC2_membrane; cl11417
449447003987	gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522
449447003988	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447003989	Walker A/P-loop; other site
449447003990	ATP binding site [chemical binding]; other site
449447003991	Q-loop/lid; other site
449447003992	ABC transporter signature motif; other site
449447003993	Walker B; other site
449447003994	D-loop; other site
449447003995	H-loop/switch region; other site
449447003996	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
449447003997	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447003998	active site
449447003999	hydrolase; Region: PLN02578
449447004000	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
449447004001	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447004002	Protein of unknown function (DUF2283); Region: DUF2283; cl02251
449447004003	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447004004	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447004005	Walker A/P-loop; other site
449447004006	ATP binding site [chemical binding]; other site
449447004007	AAA domain; Region: AAA_21; pfam13304
449447004008	Integrase core domain; Region: rve; cl01316
449447004009	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447004010	Helix-turn-helix domains; Region: HTH; cl00088
449447004011	DNA binding site [nucleotide binding]
449447004012	Winged helix-turn helix; Region: HTH_29; pfam13551
449447004013	Helix-turn-helix domains; Region: HTH; cl00088
449447004014	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
449447004015	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447004016	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447004017	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447004018	Transposase domain (DUF772); Region: DUF772; cl15789
449447004019	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
449447004020	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
449447004021	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235
449447004022	Metal binding protein ZntC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018
449447004023	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
449447004024	putative metal binding residues [ion binding]; other site
449447004025	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
449447004026	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
449447004027	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
449447004028	ATP binding site [chemical binding]; other site
449447004029	putative Mg++ binding site [ion binding]; other site
449447004030	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
449447004031	nucleotide binding region [chemical binding]; other site
449447004032	ATP-binding site [chemical binding]; other site
449447004033	TRCF domain; Region: TRCF; cl04088
449447004034	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447004035	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
449447004036	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817
449447004037	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447004038	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447004039	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447004040	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
449447004041	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
449447004042	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
449447004043	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
449447004044	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
449447004045	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
449447004046	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
449447004047	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
449447004048	Integrase core domain; Region: rve; cl01316
449447004049	Integrase core domain; Region: rve; cl01316
449447004050	Winged helix-turn helix; Region: HTH_29; pfam13551
449447004051	Helix-turn-helix domains; Region: HTH; cl00088
449447004052	Helix-turn-helix domains; Region: HTH; cl00088
449447004053	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447004054	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447004055	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447004056	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
449447004057	tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111
449447004058	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
449447004059	substrate binding site [chemical binding]; other site
449447004060	active site
449447004061	catalytic residues [active]
449447004062	heterodimer interface [polypeptide binding]; other site
449447004063	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
449447004064	putative metal binding site; other site
449447004065	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
449447004066	Helix-turn-helix domains; Region: HTH; cl00088
449447004067	Helix-turn-helix domains; Region: HTH; cl00088
449447004068	Integrase core domain; Region: rve; cl01316
449447004069	Transposase domain (DUF772); Region: DUF772; cl15789
449447004070	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447004071	Integrase core domain; Region: rve; cl01316
449447004072	Helix-turn-helix domains; Region: HTH; cl00088
449447004073	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447004074	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447004075	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447004076	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
449447004077	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
449447004078	Protein of unknown function (DUF2288); Region: DUF2288; cl02399
449447004079	peptide synthase; Validated; Region: PRK05691
449447004080	AMP-binding enzyme; Region: AMP-binding; cl15778
449447004081	AMP-binding enzyme; Region: AMP-binding; cl15778
449447004082	Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008
449447004083	Phosphopantetheine attachment site; Region: PP-binding; cl09936
449447004084	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
449447004085	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
449447004086	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
449447004087	catalytic residue [active]
449447004088	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
449447004089	Amidinotransferase; Region: Amidinotransf; cl12043
449447004090	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
449447004091	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447004092	short chain dehydrogenase; Validated; Region: PRK06182
449447004093	NAD(P) binding site [chemical binding]; other site
449447004094	active site
449447004095	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
449447004096	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
449447004097	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
449447004098	DevC protein; Region: devC; TIGR01185
449447004099	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
449447004100	FtsX-like permease family; Region: FtsX; cl15850
449447004101	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
449447004102	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
449447004103	Walker A/P-loop; other site
449447004104	ATP binding site [chemical binding]; other site
449447004105	Q-loop/lid; other site
449447004106	ABC transporter signature motif; other site
449447004107	Walker B; other site
449447004108	D-loop; other site
449447004109	H-loop/switch region; other site
449447004110	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447004111	Radical SAM superfamily; Region: Radical_SAM; pfam04055
449447004112	FeS/SAM binding site; other site
449447004113	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
449447004114	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
449447004115	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
449447004116	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
449447004117	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
449447004118	substrate binding site [chemical binding]; other site
449447004119	catalytic Zn binding site [ion binding]; other site
449447004120	NAD binding site [chemical binding]; other site
449447004121	structural Zn binding site [ion binding]; other site
449447004122	dimer interface [polypeptide binding]; other site
449447004123	CHAT domain; Region: CHAT; pfam12770
449447004124	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447004125	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447004126	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447004127	binding surface
449447004128	TPR motif; other site
449447004129	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447004130	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447004131	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447004132	TIR domain; Region: TIR_2; cl15770
449447004133	TIR domain; Region: TIR_2; cl15770
449447004134	Protein of unknown function (DUF433); Region: DUF433; cl01030
449447004135	Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385
449447004136	Stage II sporulation protein; Region: SpoIID; pfam08486
449447004137	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
449447004138	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
449447004139	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
449447004140	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
449447004141	substrate binding pocket [chemical binding]; other site
449447004142	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
449447004143	B12 binding site [chemical binding]; other site
449447004144	cobalt ligand [ion binding]; other site
449447004145	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
449447004146	Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815
449447004147	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
449447004148	NAD binding site [chemical binding]; other site
449447004149	dimerization interface [polypeptide binding]; other site
449447004150	product binding site; other site
449447004151	substrate binding site [chemical binding]; other site
449447004152	zinc binding site [ion binding]; other site
449447004153	catalytic residues [active]
449447004154	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
449447004155	Excalibur calcium-binding domain; Region: Excalibur; cl05460
449447004156	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
449447004157	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447004158	shikimate kinase; Reviewed; Region: aroK; PRK00131
449447004159	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
449447004160	ADP binding site [chemical binding]; other site
449447004161	magnesium binding site [ion binding]; other site
449447004162	putative shikimate binding site; other site
449447004163	Cupin domain; Region: Cupin_2; cl09118
449447004164	coproporphyrinogen III oxidase; Provisional; Region: PRK07379
449447004165	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447004166	FeS/SAM binding site; other site
449447004167	HemN C-terminal domain; Region: HemN_C; pfam06969
449447004168	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
449447004169	von Willebrand factor type D domain; Region: VWD; cl02516
449447004170	Calx-beta domain; Region: Calx-beta; cl02522
449447004171	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
449447004172	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
449447004173	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
449447004174	putative active site [active]
449447004175	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
449447004176	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447004177	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
449447004178	MutS domain I; Region: MutS_I; pfam01624
449447004179	MutS domain II; Region: MutS_II; pfam05188
449447004180	MutS family domain IV; Region: MutS_IV; pfam05190
449447004181	MutS1 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284
449447004182	Walker A/P-loop; other site
449447004183	ATP binding site [chemical binding]; other site
449447004184	Q-loop/lid; other site
449447004185	ABC transporter signature motif; other site
449447004186	Walker B; other site
449447004187	D-loop; other site
449447004188	H-loop/switch region; other site
449447004189	Phycobilisome protein; Region: Phycobilisome; cl08227
449447004190	gamma-glutamyl kinase; Provisional; Region: PRK05429
449447004191	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
449447004192	nucleotide binding site [chemical binding]; other site
449447004193	homotetrameric interface [polypeptide binding]; other site
449447004194	putative phosphate binding site [ion binding]; other site
449447004195	putative allosteric binding site; other site
449447004196	PUA domain; Region: PUA; cl00607
449447004197	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
449447004198	DHH family; Region: DHH; pfam01368
449447004199	DHHA1 domain; Region: DHHA1; pfam02272
449447004200	GAF domain; Region: GAF_2; pfam13185
449447004201	GAF domain; Region: GAF; cl15785
449447004202	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447004203	dimer interface [polypeptide binding]; other site
449447004204	phosphorylation site [posttranslational modification]
449447004205	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447004206	ATP binding site [chemical binding]; other site
449447004207	Mg2+ binding site [ion binding]; other site
449447004208	G-X-G motif; other site
449447004209	Response regulator receiver domain; Region: Response_reg; pfam00072
449447004210	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447004211	active site
449447004212	phosphorylation site [posttranslational modification]
449447004213	intermolecular recognition site; other site
449447004214	dimerization interface [polypeptide binding]; other site
449447004215	Repair protein; Region: Repair_PSII; cl01535
449447004216	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
449447004217	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
449447004218	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
449447004219	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
449447004220	active site
449447004221	homodimer interface [polypeptide binding]; other site
449447004222	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447004223	putative active site [active]
449447004224	Phosphotransferase enzyme family; Region: APH; pfam01636
449447004225	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
449447004226	active site
449447004227	ATP binding site [chemical binding]; other site
449447004228	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
449447004229	substrate binding site [chemical binding]; other site
449447004230	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
449447004231	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
449447004232	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
449447004233	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447004234	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
449447004235	XisI protein; Region: XisI; pfam08869
449447004236	XisH protein; Region: XisH; pfam08814
449447004237	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
449447004238	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447004239	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
449447004240	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
449447004241	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447004242	putative active site [active]
449447004243	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
449447004244	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
449447004245	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447004246	putative active site [active]
449447004247	ABC-2 type transporter; Region: ABC2_membrane; cl11417
449447004248	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
449447004249	P loop; other site
449447004250	Nucleotide binding site [chemical binding]; other site
449447004251	DTAP/Switch II; other site
449447004252	Switch I; other site
449447004253	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447004254	This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins.  sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298
449447004255	UbiA prenyltransferase family; Region: UbiA; cl00337
449447004256	BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473
449447004257	light-harvesting-like protein 3; Provisional; Region: PLN00014
449447004258	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988
449447004259	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447004260	putative active site [active]
449447004261	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447004262	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447004263	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447004264	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447004265	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447004266	DNA repair protein RadA; Provisional; Region: PRK11823
449447004267	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
449447004268	Walker A motif/ATP binding site; other site
449447004269	ATP binding site [chemical binding]; other site
449447004270	Walker B motif; other site
449447004271	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
449447004272	Ycf27; Reviewed; Region: orf27; CHL00148
449447004273	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447004274	active site
449447004275	phosphorylation site [posttranslational modification]
449447004276	intermolecular recognition site; other site
449447004277	dimerization interface [polypeptide binding]; other site
449447004278	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
449447004279	DNA binding site [nucleotide binding]
449447004280	Protein of unknown function (DUF2930); Region: DUF2930; pfam11152
449447004281	Helix-turn-helix domains; Region: HTH; cl00088
449447004282	Winged helix-turn helix; Region: HTH_29; pfam13551
449447004283	Winged helix-turn helix; Region: HTH_33; pfam13592
449447004284	Integrase core domain; Region: rve; cl01316
449447004285	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447004286	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447004287	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447004288	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447004289	Transposase domain (DUF772); Region: DUF772; cl15789
449447004290	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447004291	Helix-turn-helix domains; Region: HTH; cl00088
449447004292	Helix-turn-helix domains; Region: HTH; cl00088
449447004293	Integrase core domain; Region: rve; cl01316
449447004294	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
449447004295	Helix-turn-helix domains; Region: HTH; cl00088
449447004296	Helix-turn-helix domains; Region: HTH; cl00088
449447004297	Integrase core domain; Region: rve; cl01316
449447004298	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
449447004299	Helix-turn-helix domains; Region: HTH; cl00088
449447004300	Winged helix-turn helix; Region: HTH_29; pfam13551
449447004301	Winged helix-turn helix; Region: HTH_33; pfam13592
449447004302	Integrase core domain; Region: rve; cl01316
449447004303	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447004304	Integrase core domain; Region: rve; cl01316
449447004305	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447004306	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
449447004307	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
449447004308	Helix-turn-helix domains; Region: HTH; cl00088
449447004309	Winged helix-turn helix; Region: HTH_29; pfam13551
449447004310	Winged helix-turn helix; Region: HTH_33; pfam13592
449447004311	Integrase core domain; Region: rve; cl01316
449447004312	Helix-turn-helix domains; Region: HTH; cl00088
449447004313	Helix-turn-helix domains; Region: HTH; cl00088
449447004314	Integrase core domain; Region: rve; cl01316
449447004315	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447004316	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
449447004317	Integrase core domain; Region: rve; cl01316
449447004318	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447004319	Integrase core domain; Region: rve; cl01316
449447004320	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
449447004321	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
449447004322	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447004323	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
449447004324	putative acyl-acceptor binding pocket; other site
449447004325	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
449447004326	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
449447004327	Protein of unknown function (DUF433); Region: DUF433; cl01030
449447004328	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447004329	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447004330	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447004331	TMAO/DMSO reductase; Reviewed; Region: PRK05363
449447004332	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
449447004333	Moco binding site; other site
449447004334	metal coordination site [ion binding]; other site
449447004335	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
449447004336	Cytochrome P450; Region: p450; pfam00067
449447004337	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
449447004338	mercuric reductase; Validated; Region: PRK06370
449447004339	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
449447004340	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
449447004341	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447004342	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447004343	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447004344	Helix-turn-helix domains; Region: HTH; cl00088
449447004345	Winged helix-turn helix; Region: HTH_29; pfam13551
449447004346	Helix-turn-helix domains; Region: HTH; cl00088
449447004347	Integrase core domain; Region: rve; cl01316
449447004348	YcfA-like protein; Region: YcfA; cl00752
449447004349	YcfA-like protein; Region: YcfA; cl00752
449447004350	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
449447004351	PemK-like protein; Region: PemK; cl00995
449447004352	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
449447004353	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
449447004354	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
449447004355	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
449447004356	Protein kinase domain; Region: Pkinase; pfam00069
449447004357	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447004358	active site
449447004359	ATP binding site [chemical binding]; other site
449447004360	substrate binding site [chemical binding]; other site
449447004361	activation loop (A-loop); other site
449447004362	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447004363	Predicted ATPase [General function prediction only]; Region: COG3899
449447004364	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
449447004365	GAF domain; Region: GAF; cl15785
449447004366	PAS fold; Region: PAS_4; pfam08448
449447004367	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
449447004368	putative active site [active]
449447004369	heme pocket [chemical binding]; other site
449447004370	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
449447004371	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
449447004372	catalytic residues [active]
449447004373	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
449447004374	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447004375	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447004376	Probable transposase; Region: OrfB_IS605; pfam01385
449447004377	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447004378	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
449447004379	dimer interface [polypeptide binding]; other site
449447004380	allosteric magnesium binding site [ion binding]; other site
449447004381	active site
449447004382	aspartate-rich active site metal binding site; other site
449447004383	Schiff base residues; other site
449447004384	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
449447004385	homodecamer interface [polypeptide binding]; other site
449447004386	GTP cyclohydrolase I; Provisional; Region: PLN03044
449447004387	active site
449447004388	putative catalytic site residues [active]
449447004389	zinc binding site [ion binding]; other site
449447004390	GTP-CH-I/GFRP interaction surface; other site
449447004391	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
449447004392	active site
449447004393	catalytic residues [active]
449447004394	metal binding site [ion binding]; metal-binding site
449447004395	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
449447004396	DnaA N-terminal domain; Region: DnaA_N; pfam11638
449447004397	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447004398	Walker A motif; other site
449447004399	ATP binding site [chemical binding]; other site
449447004400	Walker B motif; other site
449447004401	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447004402	arginine finger; other site
449447004403	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
449447004404	DnaA box-binding interface [nucleotide binding]; other site
449447004405	UbiA prenyltransferase family; Region: UbiA; cl00337
449447004406	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
449447004407	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
449447004408	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
449447004409	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
449447004410	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
449447004411	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
449447004412	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
449447004413	D-pathway; other site
449447004414	Low-spin heme binding site [chemical binding]; other site
449447004415	Putative water exit pathway; other site
449447004416	Binuclear center (active site) [active]
449447004417	K-pathway; other site
449447004418	Putative proton exit pathway; other site
449447004419	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
449447004420	Subunit I/III interface [polypeptide binding]; other site
449447004421	Phosphopantetheine attachment site; Region: PP-binding; cl09936
449447004422	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
449447004423	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
449447004424	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
449447004425	active site
449447004426	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
449447004427	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
449447004428	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447004429	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447004430	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
449447004431	active site
449447004432	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
449447004433	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
449447004434	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
449447004435	catalytic residue [active]
449447004436	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
449447004437	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
449447004438	sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131
449447004439	ABC-type transport system involved in Fe-S cluster assembly, ATPase component.  Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems.  The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217
449447004440	Walker A/P-loop; other site
449447004441	ATP binding site [chemical binding]; other site
449447004442	Q-loop/lid; other site
449447004443	ABC transporter signature motif; other site
449447004444	Walker B; other site
449447004445	D-loop; other site
449447004446	H-loop/switch region; other site
449447004447	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
449447004448	putative ABC transporter; Region: ycf24; CHL00085
449447004449	iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702
449447004450	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
449447004451	putative DNA binding site [nucleotide binding]; other site
449447004452	putative Zn2+ binding site [ion binding]; other site
449447004453	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447004454	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447004455	Probable transposase; Region: OrfB_IS605; pfam01385
449447004456	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447004457	Sulfotransferase family; Region: Sulfotransfer_3; cl14559
449447004458	CAAX protease self-immunity; Region: Abi; cl00558
449447004459	putative glycosyl transferase; Provisional; Region: PRK10307
449447004460	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
449447004461	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
449447004462	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
449447004463	ATP-grasp domain; Region: ATP-grasp_4; cl03087
449447004464	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
449447004465	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447004466	Probable transposase; Region: OrfB_IS605; pfam01385
449447004467	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447004468	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
449447004469	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
449447004470	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
449447004471	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
449447004472	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447004473	Transposase domain (DUF772); Region: DUF772; cl15789
449447004474	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
449447004475	DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095
449447004476	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
449447004477	ATP binding site [chemical binding]; other site
449447004478	putative Mg++ binding site [ion binding]; other site
449447004479	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
449447004480	nucleotide binding region [chemical binding]; other site
449447004481	ATP-binding site [chemical binding]; other site
449447004482	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
449447004483	putative RNA binding site [nucleotide binding]; other site
449447004484	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
449447004485	putative active site [active]
449447004486	putative metal binding residues [ion binding]; other site
449447004487	signature motif; other site
449447004488	putative dimer interface [polypeptide binding]; other site
449447004489	putative phosphate binding site [ion binding]; other site
449447004490	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
449447004491	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
449447004492	dimer interface [polypeptide binding]; other site
449447004493	active site
449447004494	glutathione binding site [chemical binding]; other site
449447004495	metal binding site [ion binding]; metal-binding site
449447004496	Integrase core domain; Region: rve; cl01316
449447004497	Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795
449447004498	anthranilate synthase component I; Provisional; Region: PRK13565
449447004499	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
449447004500	chorismate binding enzyme; Region: Chorismate_bind; cl10555
449447004501	PsaD; Region: PsaD; cl03639
449447004502	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
449447004503	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447004504	ABC-ATPase subunit interface; other site
449447004505	putative PBP binding loops; other site
449447004506	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447004507	dimer interface [polypeptide binding]; other site
449447004508	conserved gate region; other site
449447004509	putative PBP binding loops; other site
449447004510	ABC-ATPase subunit interface; other site
449447004511	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
449447004512	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
449447004513	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
449447004514	glutamine binding [chemical binding]; other site
449447004515	catalytic triad [active]
449447004516	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447004517	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447004518	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
449447004519	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
449447004520	NlpC/P60 family; Region: NLPC_P60; cl11438
449447004521	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
449447004522	Probable transposase; Region: OrfB_IS605; pfam01385
449447004523	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447004524	Helix-turn-helix domains; Region: HTH; cl00088
449447004525	Winged helix-turn helix; Region: HTH_29; pfam13551
449447004526	Helix-turn-helix domains; Region: HTH; cl00088
449447004527	Integrase core domain; Region: rve; cl01316
449447004528	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447004529	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447004530	Transposase [DNA replication, recombination, and repair]; Region: COG5433
449447004531	Calx-beta domain; Region: Calx-beta; cl02522
449447004532	Calx-beta domain; Region: Calx-beta; cl02522
449447004533	Calx-beta domain; Region: Calx-beta; cl02522
449447004534	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
449447004535	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
449447004536	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447004537	Walker A/P-loop; other site
449447004538	ATP binding site [chemical binding]; other site
449447004539	Q-loop/lid; other site
449447004540	ABC transporter signature motif; other site
449447004541	Walker B; other site
449447004542	D-loop; other site
449447004543	H-loop/switch region; other site
449447004544	Smr domain; Region: Smr; cl02619
449447004545	Photosystem II Pbs27; Region: PSII_Pbs27; cl11841
449447004546	CHASE3 domain; Region: CHASE3; cl05000
449447004547	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447004548	dimer interface [polypeptide binding]; other site
449447004549	phosphorylation site [posttranslational modification]
449447004550	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447004551	ATP binding site [chemical binding]; other site
449447004552	G-X-G motif; other site
449447004553	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447004554	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447004555	Probable transposase; Region: OrfB_IS605; pfam01385
449447004556	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447004557	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
449447004558	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447004559	active site
449447004560	phosphorylation site [posttranslational modification]
449447004561	intermolecular recognition site; other site
449447004562	dimerization interface [polypeptide binding]; other site
449447004563	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
449447004564	DNA binding site [nucleotide binding]
449447004565	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447004566	putative active site [active]
449447004567	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
449447004568	NADH(P)-binding; Region: NAD_binding_10; pfam13460
449447004569	NAD(P) binding site [chemical binding]; other site
449447004570	putative active site [active]
449447004571	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
449447004572	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
449447004573	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
449447004574	G1 box; other site
449447004575	putative GEF interaction site [polypeptide binding]; other site
449447004576	GTP/Mg2+ binding site [chemical binding]; other site
449447004577	Switch I region; other site
449447004578	G2 box; other site
449447004579	G3 box; other site
449447004580	Switch II region; other site
449447004581	G4 box; other site
449447004582	G5 box; other site
449447004583	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
449447004584	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
449447004585	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812
449447004586	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
449447004587	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
449447004588	active site
449447004589	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
449447004590	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
449447004591	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
449447004592	Catalytic site [active]
449447004593	4Fe-4S binding domain; Region: Fer4_5; pfam12801
449447004594	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
449447004595	EF-hand domain pair; Region: EF_hand_5; pfam13499
449447004596	Ca2+ binding site [ion binding]; other site
449447004597	Uncharacterized conserved protein (DUF2290); Region: DUF2290; cl02396
449447004598	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972
449447004599	Family description; Region: UvrD_C_2; cl15862
449447004600	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
449447004601	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
449447004602	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583
449447004603	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234
449447004604	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
449447004605	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
449447004606	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234
449447004607	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
449447004608	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
449447004609	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234
449447004610	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
449447004611	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
449447004612	putative active site [active]
449447004613	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
449447004614	Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
449447004615	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447004616	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447004617	Walker A/P-loop; other site
449447004618	ATP binding site [chemical binding]; other site
449447004619	Q-loop/lid; other site
449447004620	ABC transporter signature motif; other site
449447004621	Walker B; other site
449447004622	D-loop; other site
449447004623	H-loop/switch region; other site
449447004624	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
449447004625	AMP binding site [chemical binding]; other site
449447004626	metal binding site [ion binding]; metal-binding site
449447004627	active site
449447004628	Protein of unknown function (DUF3153); Region: DUF3153; pfam11353
449447004629	Exoribonuclease R [Transcription]; Region: VacB; COG0557
449447004630	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
449447004631	RNB domain; Region: RNB; pfam00773
449447004632	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471
449447004633	RNA binding site [nucleotide binding]; other site
449447004634	Domain of unknown function (DUF4377); Region: DUF4377; pfam14302
449447004635	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
449447004636	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494
449447004637	Protein of unknown function (DUF2488); Region: Ycf54; pfam10674
449447004638	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
449447004639	PLD-like domain; Region: PLDc_2; pfam13091
449447004640	putative active site [active]
449447004641	catalytic site [active]
449447004642	Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173
449447004643	PLD-like domain; Region: PLDc_2; pfam13091
449447004644	putative active site [active]
449447004645	catalytic site [active]
449447004646	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
449447004647	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
449447004648	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
449447004649	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447004650	G1 box; other site
449447004651	GTP/Mg2+ binding site [chemical binding]; other site
449447004652	G2 box; other site
449447004653	Switch I region; other site
449447004654	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447004655	G3 box; other site
449447004656	Switch II region; other site
449447004657	G4 box; other site
449447004658	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
449447004659	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447004660	putative active site [active]
449447004661	Membrane transport protein; Region: Mem_trans; cl09117
449447004662	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447004663	Helix-turn-helix domains; Region: HTH; cl00088
449447004664	Integrase core domain; Region: rve; cl01316
449447004665	O-Antigen ligase; Region: Wzy_C; cl04850
449447004666	O-Antigen ligase; Region: Wzy_C; cl04850
449447004667	Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045
449447004668	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
449447004669	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447004670	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
449447004671	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
449447004672	Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome.  The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223
449447004673	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
449447004674	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
449447004675	ATP-grasp domain; Region: ATP-grasp_4; cl03087
449447004676	ATP-grasp domain; Region: ATP-grasp_4; cl03087
449447004677	Serine endopeptidase inhibitors; Region: Inhibitor_I10; pfam12559
449447004678	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
449447004679	antiporter inner membrane protein; Provisional; Region: PRK11670
449447004680	Domain of unknown function DUF59; Region: DUF59; cl00941
449447004681	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
449447004682	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
449447004683	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
449447004684	MOSC domain; Region: MOSC; pfam03473
449447004685	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447004686	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
449447004687	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447004688	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
449447004689	amidase; Provisional; Region: PRK09201
449447004690	Amidase; Region: Amidase; cl11426
449447004691	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
449447004692	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
449447004693	B12 binding site [chemical binding]; other site
449447004694	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447004695	FeS/SAM binding site; other site
449447004696	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
449447004697	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
449447004698	putative ligand binding site [chemical binding]; other site
449447004699	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
449447004700	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447004701	Maf-like protein; Region: Maf; pfam02545
449447004702	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
449447004703	active site
449447004704	dimer interface [polypeptide binding]; other site
449447004705	PsbP; Region: PsbP; cl03356
449447004706	TPR repeat; Region: TPR_11; pfam13414
449447004707	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447004708	binding surface
449447004709	TPR motif; other site
449447004710	TPR repeat; Region: TPR_11; pfam13414
449447004711	TPR repeat; Region: TPR_11; pfam13414
449447004712	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447004713	binding surface
449447004714	TPR motif; other site
449447004715	TPR repeat; Region: TPR_11; pfam13414
449447004716	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447004717	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
449447004718	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
449447004719	active site
449447004720	HIGH motif; other site
449447004721	dimer interface [polypeptide binding]; other site
449447004722	KMSKS motif; other site
449447004723	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
449447004724	Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928
449447004725	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447004726	putative active site [active]
449447004727	DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096
449447004728	DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096
449447004729	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447004730	photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069
449447004731	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
449447004732	RNA binding surface [nucleotide binding]; other site
449447004733	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
449447004734	YcfA-like protein; Region: YcfA; cl00752
449447004735	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
449447004736	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
449447004737	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
449447004738	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
449447004739	feedback inhibition sensing region; other site
449447004740	homohexameric interface [polypeptide binding]; other site
449447004741	nucleotide binding site [chemical binding]; other site
449447004742	N-acetyl-L-glutamate binding site [chemical binding]; other site
449447004743	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
449447004744	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
449447004745	metal binding site [ion binding]; metal-binding site
449447004746	dimer interface [polypeptide binding]; other site
449447004747	Phycobilisome protein; Region: Phycobilisome; cl08227
449447004748	Phycobilisome protein; Region: Phycobilisome; cl08227
449447004749	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
449447004750	CpcD/allophycocyanin linker domain; Region: CpcD; cl03191
449447004751	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
449447004752	CpcD/allophycocyanin linker domain; Region: CpcD; cl03191
449447004753	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319
449447004754	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
449447004755	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
449447004756	dimerization interface [polypeptide binding]; other site
449447004757	active site
449447004758	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447004759	putative active site [active]
449447004760	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
449447004761	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
449447004762	ATP-grasp domain; Region: ATP-grasp_4; cl03087
449447004763	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
449447004764	chaperone protein DnaJ; Provisional; Region: PRK14300
449447004765	transcriptional regulator EutR; Provisional; Region: PRK10130
449447004766	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
449447004767	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
449447004768	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364
449447004769	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447004770	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
449447004771	TPR motif; other site
449447004772	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447004773	binding surface
449447004774	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447004775	binding surface
449447004776	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447004777	Helix-turn-helix domains; Region: HTH; cl00088
449447004778	Integrase core domain; Region: rve; cl01316
449447004779	PemK-like protein; Region: PemK; cl00995
449447004780	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
449447004781	TPR repeat; Region: TPR_11; pfam13414
449447004782	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447004783	binding surface
449447004784	TPR motif; other site
449447004785	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447004786	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447004787	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447004788	binding surface
449447004789	TPR motif; other site
449447004790	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447004791	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447004792	binding surface
449447004793	TPR motif; other site
449447004794	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447004795	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447004796	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
449447004797	CHAT domain; Region: CHAT; pfam12770
449447004798	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
449447004799	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447004800	Protein of unknown function (DUF433); Region: DUF433; cl01030
449447004801	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
449447004802	active site
449447004803	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447004804	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447004805	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447004806	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447004807	binding surface
449447004808	TPR motif; other site
449447004809	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447004810	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447004811	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447004812	binding surface
449447004813	TPR motif; other site
449447004814	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447004815	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447004816	CHAT domain; Region: CHAT; pfam12770
449447004817	haemagglutination activity domain; Region: Haemagg_act; cl05436
449447004818	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447004819	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447004820	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
449447004821	Surface antigen; Region: Bac_surface_Ag; cl03097
449447004822	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
449447004823	Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042
449447004824	tocopherol O-methyltransferase; Region: PLN02244
449447004825	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447004826	S-adenosylmethionine binding site [chemical binding]; other site
449447004827	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
449447004828	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
449447004829	putative peptidoglycan binding site; other site
449447004830	cell division protein DedD; Provisional; Region: PRK11633
449447004831	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
449447004832	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
449447004833	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
449447004834	putative peptidoglycan binding site; other site
449447004835	Peptidase family M23; Region: Peptidase_M23; pfam01551
449447004836	Helix-turn-helix domains; Region: HTH; cl00088
449447004837	Integrase core domain; Region: rve; cl01316
449447004838	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
449447004839	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
449447004840	Integrase core domain; Region: rve; cl01316
449447004841	Integrase core domain; Region: rve; cl01316
449447004842	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
449447004843	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
449447004844	HflX GTPase family; Region: HflX; cd01878
449447004845	G1 box; other site
449447004846	GTP/Mg2+ binding site [chemical binding]; other site
449447004847	Switch I region; other site
449447004848	G2 box; other site
449447004849	G3 box; other site
449447004850	Switch II region; other site
449447004851	G4 box; other site
449447004852	G5 box; other site
449447004853	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
449447004854	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
449447004855	inhibitor-cofactor binding pocket; inhibition site
449447004856	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447004857	catalytic residue [active]
449447004858	Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424
449447004859	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403
449447004860	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447004861	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
449447004862	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
449447004863	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
449447004864	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
449447004865	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
449447004866	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
449447004867	FAD binding domain; Region: FAD_binding_4; pfam01565
449447004868	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
449447004869	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
449447004870	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
449447004871	peptide binding site [polypeptide binding]; other site
449447004872	dimer interface [polypeptide binding]; other site
449447004873	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
449447004874	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447004875	dimer interface [polypeptide binding]; other site
449447004876	conserved gate region; other site
449447004877	putative PBP binding loops; other site
449447004878	ABC-ATPase subunit interface; other site
449447004879	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
449447004880	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
449447004881	dimer interface [polypeptide binding]; other site
449447004882	putative metal binding site [ion binding]; other site
449447004883	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
449447004884	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
449447004885	ResB-like family; Region: ResB; pfam05140
449447004886	formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945
449447004887	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
449447004888	DNA binding site [nucleotide binding]
449447004889	catalytic residue [active]
449447004890	H2TH interface [polypeptide binding]; other site
449447004891	putative catalytic residues [active]
449447004892	turnover-facilitating residue; other site
449447004893	intercalation triad [nucleotide binding]; other site
449447004894	8OG recognition residue [nucleotide binding]; other site
449447004895	putative reading head residues; other site
449447004896	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
449447004897	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
449447004898	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447004899	binding surface
449447004900	TPR motif; other site
449447004901	TPR repeat; Region: TPR_11; pfam13414
449447004902	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447004903	binding surface
449447004904	TPR motif; other site
449447004905	Predicted integral membrane protein [Function unknown]; Region: COG0392
449447004906	FOG: WD40 repeat [General function prediction only]; Region: COG2319
449447004907	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447004908	structural tetrad; other site
449447004909	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447004910	structural tetrad; other site
449447004911	DNA polymerase III subunit delta; Validated; Region: PRK07452
449447004912	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
449447004913	CHAT domain; Region: CHAT; pfam12770
449447004914	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
449447004915	phosphopeptide binding site; other site
449447004916	magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383
449447004917	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
449447004918	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
449447004919	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
449447004920	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
449447004921	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
449447004922	NAD(P) binding site [chemical binding]; other site
449447004923	catalytic residues [active]
449447004924	Domain of unknown function (DUF1825); Region: DUF1825; pfam08855
449447004925	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
449447004926	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
449447004927	catalytic residue [active]
449447004928	putative FPP diphosphate  binding site; other site
449447004929	putative FPP binding hydrophobic cleft; other site
449447004930	dimer interface [polypeptide binding]; other site
449447004931	putative IPP diphosphate binding site; other site
449447004932	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
449447004933	diaminopimelate decarboxylase; Region: lysA; TIGR01048
449447004934	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
449447004935	active site
449447004936	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
449447004937	substrate binding site [chemical binding]; other site
449447004938	catalytic residues [active]
449447004939	dimer interface [polypeptide binding]; other site
449447004940	GUN4-like; Region: GUN4; pfam05419
449447004941	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
449447004942	TIGR01777 family protein; Region: yfcH
449447004943	putative NAD(P) binding site [chemical binding]; other site
449447004944	putative active site [active]
449447004945	Psb28 protein; Region: Psb28; cl04326
449447004946	Uncharacterized ACR, COG1430; Region: DUF192; cl00627
449447004947	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
449447004948	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
449447004949	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
449447004950	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447004951	Helix-turn-helix domains; Region: HTH; cl00088
449447004952	Integrase core domain; Region: rve; cl01316
449447004953	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
449447004954	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
449447004955	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447004956	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447004957	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
449447004958	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
449447004959	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
449447004960	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673
449447004961	motif 1; other site
449447004962	active site
449447004963	motif 2; other site
449447004964	motif 3; other site
449447004965	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
449447004966	Protein of unknown function (DUF497); Region: DUF497; cl01108
449447004967	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
449447004968	Uncharacterized BCR, COG1649; Region: DUF187; cl15398
449447004969	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
449447004970	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
449447004971	DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796
449447004972	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
449447004973	Walker A motif; other site
449447004974	ATP binding site [chemical binding]; other site
449447004975	Walker B motif; other site
449447004976	DNA binding loops [nucleotide binding]
449447004977	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
449447004978	protein-splicing catalytic site; other site
449447004979	thioester formation/cholesterol transfer; other site
449447004980	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447004981	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
449447004982	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
449447004983	TspO/MBR family; Region: TspO_MBR; cl01379
449447004984	The SUI1/eIF1 (eukaryotic initiation factor 1) fold is found in eukaryotes, archaea, and some bacteria and is thought to play an important role in accurate initiator codon recognition during translation initiation. This fold, which includes two...; Region: SUI1_eIF1; cd00474
449447004985	Predicted RNA interaction site [nucleotide binding]; other site
449447004986	putative binding site; other site
449447004987	Mutations affecting start-site selection; other site
449447004988	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
449447004989	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
449447004990	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
449447004991	RNA polymerase factor sigma-70; Validated; Region: PRK08295
449447004992	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912
449447004993	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
449447004994	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
449447004995	putative active site [active]
449447004996	metal binding site [ion binding]; metal-binding site
449447004997	Protein of function (DUF2518); Region: DUF2518; pfam10726
449447004998	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
449447004999	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
449447005000	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
449447005001	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
449447005002	Ligand Binding Site [chemical binding]; other site
449447005003	Domain of unknown function DUF; Region: DUF204; pfam02659
449447005004	Domain of unknown function DUF; Region: DUF204; pfam02659
449447005005	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
449447005006	TM-ABC transporter signature motif; other site
449447005007	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
449447005008	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
449447005009	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
449447005010	Clp protease ATP binding subunit; Region: clpC; CHL00095
449447005011	Clp amino terminal domain; Region: Clp_N; pfam02861
449447005012	Clp amino terminal domain; Region: Clp_N; pfam02861
449447005013	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447005014	Walker A motif; other site
449447005015	ATP binding site [chemical binding]; other site
449447005016	Walker B motif; other site
449447005017	arginine finger; other site
449447005018	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447005019	Walker A motif; other site
449447005020	ATP binding site [chemical binding]; other site
449447005021	Walker B motif; other site
449447005022	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
449447005023	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
449447005024	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
449447005025	putative active site [active]
449447005026	catalytic triad [active]
449447005027	putative dimer interface [polypeptide binding]; other site
449447005028	GAF domain; Region: GAF; cl15785
449447005029	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447005030	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
449447005031	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
449447005032	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
449447005033	putative active site [active]
449447005034	catalytic site [active]
449447005035	putative substrate binding site [chemical binding]; other site
449447005036	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
449447005037	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
449447005038	anti sigma factor interaction site; other site
449447005039	regulatory phosphorylation site [posttranslational modification]; other site
449447005040	Bacterial sugar transferase; Region: Bac_transf; cl00939
449447005041	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
449447005042	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447005043	Transposase domain (DUF772); Region: DUF772; cl15789
449447005044	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
449447005045	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447005046	active site
449447005047	ATP binding site [chemical binding]; other site
449447005048	substrate binding site [chemical binding]; other site
449447005049	activation loop (A-loop); other site
449447005050	GUN4-like; Region: GUN4; pfam05419
449447005051	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
449447005052	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
449447005053	active site
449447005054	metal binding site [ion binding]; metal-binding site
449447005055	DNA binding site [nucleotide binding]
449447005056	PetN; Region: PetN; cl15376
449447005057	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
449447005058	active site
449447005059	dimer interface [polypeptide binding]; other site
449447005060	metal binding site [ion binding]; metal-binding site
449447005061	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
449447005062	Predicted ATPase [General function prediction only]; Region: COG4637
449447005063	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447005064	Walker A/P-loop; other site
449447005065	ATP binding site [chemical binding]; other site
449447005066	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
449447005067	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
449447005068	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
449447005069	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447005070	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
449447005071	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
449447005072	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
449447005073	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
449447005074	active site
449447005075	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519
449447005076	active site flap/lid [active]
449447005077	nucleophilic elbow; other site
449447005078	catalytic triad [active]
449447005079	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
449447005080	active site
449447005081	Jacalin-like lectin domain of griffithsin and related proteins; Region: griffithsin_like; cd09614
449447005082	sugar binding site [chemical binding]; other site
449447005083	Jacalin-like lectin domain of griffithsin and related proteins; Region: griffithsin_like; cd09614
449447005084	sugar binding site [chemical binding]; other site
449447005085	Uncharacterized conserved protein containing a coiled-coil domain [Function unknown]; Region: COG5493
449447005086	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519
449447005087	nucleophilic elbow; other site
449447005088	catalytic triad [active]
449447005089	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
449447005090	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
449447005091	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
449447005092	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
449447005093	phosphopeptide binding site; other site
449447005094	Domain of unknown function DUF20; Region: UPF0118; pfam01594
449447005095	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
449447005096	C-terminal peptidase (prc); Region: prc; TIGR00225
449447005097	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
449447005098	protein binding site [polypeptide binding]; other site
449447005099	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
449447005100	Catalytic dyad [active]
449447005101	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
449447005102	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
449447005103	Cell division protein FtsQ; Region: FtsQ; pfam03799
449447005104	cell division protein FtsZ; Validated; Region: PRK09330
449447005105	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
449447005106	nucleotide binding site [chemical binding]; other site
449447005107	SulA interaction site; other site
449447005108	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
449447005109	dimer interface [polypeptide binding]; other site
449447005110	substrate binding site [chemical binding]; other site
449447005111	ATP binding site [chemical binding]; other site
449447005112	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447005113	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447005114	Probable transposase; Region: OrfB_IS605; pfam01385
449447005115	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447005116	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
449447005117	Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042
449447005118	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447005119	Helix-turn-helix domains; Region: HTH; cl00088
449447005120	Winged helix-turn helix; Region: HTH_29; pfam13551
449447005121	Winged helix-turn helix; Region: HTH_33; pfam13592
449447005122	Integrase core domain; Region: rve; cl01316
449447005123	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447005124	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447005125	Group XII secretory phospholipase A2 precursor (PLA2G12); Region: PLA2G12; pfam06951
449447005126	Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428
449447005127	Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696
449447005128	Protein of unknown function (DUF3571); Region: DUF3571; pfam12095
449447005129	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
449447005130	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
449447005131	dimer interface [polypeptide binding]; other site
449447005132	tetramer interface [polypeptide binding]; other site
449447005133	PYR/PP interface [polypeptide binding]; other site
449447005134	TPP binding site [chemical binding]; other site
449447005135	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
449447005136	TPP-binding site; other site
449447005137	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
449447005138	MPN+ (JAMM) motif; other site
449447005139	Zinc-binding site [ion binding]; other site
449447005140	Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133
449447005141	conserved hypothetical protein; Region: TIGR03492
449447005142	Nucleopolyhedrovirus P10 protein; Region: NPV_P10; pfam05531
449447005143	Haemolysin XhlA; Region: XhlA; pfam10779
449447005144	Haemolysin XhlA; Region: XhlA; pfam10779
449447005145	conserved hypothetical protein YmdA/YtgF; Region: YmdA_YtgF; TIGR03319
449447005146	Haemolysin XhlA; Region: XhlA; pfam10779
449447005147	Haemolysin XhlA; Region: XhlA; pfam10779
449447005148	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447005149	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447005150	binding surface
449447005151	TPR motif; other site
449447005152	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447005153	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447005154	binding surface
449447005155	TPR motif; other site
449447005156	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447005157	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447005158	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447005159	binding surface
449447005160	TPR motif; other site
449447005161	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447005162	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447005163	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447005164	binding surface
449447005165	TPR motif; other site
449447005166	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447005167	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447005168	Lysyl-tRNA synthetase (class I) [Translation, ribosomal structure and biogenesis]; Region: LysS; COG1384
449447005169	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
449447005170	active site
449447005171	nucleotide binding site [chemical binding]; other site
449447005172	HIGH motif; other site
449447005173	KMSKS motif; other site
449447005174	Protein of unknown function (DUF1257); Region: DUF1257; cl06088
449447005175	Ycf46; Provisional; Region: ycf46; CHL00195
449447005176	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447005177	Walker A motif; other site
449447005178	ATP binding site [chemical binding]; other site
449447005179	Walker B motif; other site
449447005180	arginine finger; other site
449447005181	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
449447005182	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
449447005183	Walker A/P-loop; other site
449447005184	ATP binding site [chemical binding]; other site
449447005185	Q-loop/lid; other site
449447005186	ABC transporter signature motif; other site
449447005187	Walker B; other site
449447005188	D-loop; other site
449447005189	H-loop/switch region; other site
449447005190	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
449447005191	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
449447005192	substrate binding pocket [chemical binding]; other site
449447005193	membrane-bound complex binding site; other site
449447005194	hinge residues; other site
449447005195	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447005196	dimer interface [polypeptide binding]; other site
449447005197	conserved gate region; other site
449447005198	putative PBP binding loops; other site
449447005199	ABC-ATPase subunit interface; other site
449447005200	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447005201	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447005202	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
449447005203	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
449447005204	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
449447005205	catalytic residues [active]
449447005206	catalytic nucleophile [active]
449447005207	Probable transposase; Region: OrfB_IS605; pfam01385
449447005208	Probable transposase; Region: OrfB_IS605; pfam01385
449447005209	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447005210	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447005211	PemK-like protein; Region: PemK; cl00995
449447005212	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447005213	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447005214	Probable transposase; Region: OrfB_IS605; pfam01385
449447005215	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447005216	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447005217	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447005218	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447005219	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447005220	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447005221	Transposase domain (DUF772); Region: DUF772; cl15789
449447005222	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
449447005223	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
449447005224	glutaminase active site [active]
449447005225	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
449447005226	dimer interface [polypeptide binding]; other site
449447005227	active site
449447005228	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
449447005229	dimer interface [polypeptide binding]; other site
449447005230	active site
449447005231	Probable transposase; Region: OrfB_IS605; pfam01385
449447005232	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447005233	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447005234	Protein of unknown function (DUF3067); Region: DUF3067; pfam11267
449447005235	PEP-CTERM motif; Region: VPEP; cl15443
449447005236	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447005237	Transposase domain (DUF772); Region: DUF772; cl15789
449447005238	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447005239	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447005240	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
449447005241	glucokinase, proteobacterial type; Region: glk; TIGR00749
449447005242	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051
449447005243	putative hexamer interface [polypeptide binding]; other site
449447005244	putative hexagonal pore; other site
449447005245	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052
449447005246	putative hexamer interface [polypeptide binding]; other site
449447005247	putative hexagonal pore; other site
449447005248	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
449447005249	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
449447005250	Transposase; Region: DEDD_Tnp_IS110; pfam01548
449447005251	Helix-turn-helix domains; Region: HTH; cl00088
449447005252	Helix-turn-helix domains; Region: HTH; cl00088
449447005253	Integrase core domain; Region: rve; cl01316
449447005254	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447005255	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
449447005256	Ribosomal protein S21; Region: Ribosomal_S21; cl00529
449447005257	Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158
449447005258	putative homotetramer interface [polypeptide binding]; other site
449447005259	putative homodimer interface [polypeptide binding]; other site
449447005260	putative metal binding site [ion binding]; other site
449447005261	putative homodimer-homodimer interface [polypeptide binding]; other site
449447005262	putative allosteric switch controlling residues; other site
449447005263	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
449447005264	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
449447005265	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
449447005266	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
449447005267	Helix-turn-helix domains; Region: HTH; cl00088
449447005268	Winged helix-turn helix; Region: HTH_29; pfam13551
449447005269	Winged helix-turn helix; Region: HTH_33; pfam13592
449447005270	Integrase core domain; Region: rve; cl01316
449447005271	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447005272	Probable transposase; Region: OrfB_IS605; pfam01385
449447005273	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447005274	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447005275	Integrase core domain; Region: rve; cl01316
449447005276	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
449447005277	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
449447005278	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
449447005279	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447005280	active site
449447005281	ATP binding site [chemical binding]; other site
449447005282	substrate binding site [chemical binding]; other site
449447005283	activation loop (A-loop); other site
449447005284	TPR repeat; Region: TPR_11; pfam13414
449447005285	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447005286	binding surface
449447005287	TPR motif; other site
449447005288	TPR repeat; Region: TPR_11; pfam13414
449447005289	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447005290	binding surface
449447005291	TPR motif; other site
449447005292	TPR repeat; Region: TPR_11; pfam13414
449447005293	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
449447005294	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
449447005295	proposed catalytic triad [active]
449447005296	active site nucleophile [active]
449447005297	cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068
449447005298	ATP-grasp domain; Region: ATP-grasp_4; cl03087
449447005299	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
449447005300	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
449447005301	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447005302	Helix-turn-helix domains; Region: HTH; cl00088
449447005303	Winged helix-turn helix; Region: HTH_29; pfam13551
449447005304	Helix-turn-helix domains; Region: HTH; cl00088
449447005305	Integrase core domain; Region: rve; cl01316
449447005306	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine...; Region: adenosine_kinase; cd01168
449447005307	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
449447005308	substrate binding site [chemical binding]; other site
449447005309	ATP binding site [chemical binding]; other site
449447005310	Protein of unknown function (DUF2555); Region: DUF2555; pfam10742
449447005311	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447005312	NAD(P) binding site [chemical binding]; other site
449447005313	active site
449447005314	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
449447005315	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
449447005316	TM2 domain; Region: TM2; cl00984
449447005317	Short C-terminal domain; Region: SHOCT; cl01373
449447005318	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
449447005319	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
449447005320	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447005321	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447005322	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447005323	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447005324	Probable transposase; Region: OrfB_IS605; pfam01385
449447005325	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447005326	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
449447005327	Protein export membrane protein; Region: SecD_SecF; cl14618
449447005328	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
449447005329	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
449447005330	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447005331	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
449447005332	PAS domain; Region: PAS_9; pfam13426
449447005333	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
449447005334	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
449447005335	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
449447005336	MutS2 family protein; Region: mutS2; TIGR01069
449447005337	Phosphopantetheine attachment site; Region: PP-binding; cl09936
449447005338	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
449447005339	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447005340	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447005341	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
449447005342	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
449447005343	active site
449447005344	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
449447005345	Acyl transferase domain; Region: Acyl_transf_1; cl08282
449447005346	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
449447005347	putative NADP binding site [chemical binding]; other site
449447005348	active site
449447005349	Phosphopantetheine attachment site; Region: PP-binding; cl09936
449447005350	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
449447005351	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
449447005352	active site
449447005353	Acyl transferase domain; Region: Acyl_transf_1; cl08282
449447005354	Phosphopantetheine attachment site; Region: PP-binding; cl09936
449447005355	Condensation domain; Region: Condensation; pfam00668
449447005356	Phosphopantetheine attachment site; Region: PP-binding; cl09936
449447005357	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
449447005358	AMP-binding enzyme; Region: AMP-binding; cl15778
449447005359	Condensation domain; Region: Condensation; pfam00668
449447005360	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
449447005361	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
449447005362	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
449447005363	active site
449447005364	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
449447005365	Acyl transferase domain; Region: Acyl_transf_1; cl08282
449447005366	Phosphopantetheine attachment site; Region: PP-binding; cl09936
449447005367	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447005368	polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813
449447005369	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
449447005370	putative NADP binding site [chemical binding]; other site
449447005371	active site
449447005372	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
449447005373	active site
449447005374	Acyl transferase domain; Region: Acyl_transf_1; cl08282
449447005375	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
449447005376	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
449447005377	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
449447005378	active site 1 [active]
449447005379	dimer interface [polypeptide binding]; other site
449447005380	active site 2 [active]
449447005381	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
449447005382	active site 1 [active]
449447005383	dimer interface [polypeptide binding]; other site
449447005384	active site 2 [active]
449447005385	2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase  FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742
449447005386	FMN binding site [chemical binding]; other site
449447005387	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
449447005388	substrate binding site [chemical binding]; other site
449447005389	putative catalytic residue [active]
449447005390	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
449447005391	Major Facilitator Superfamily; Region: MFS_1; pfam07690
449447005392	putative substrate translocation pore; other site
449447005393	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447005394	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
449447005395	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
449447005396	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447005397	Walker A/P-loop; other site
449447005398	ATP binding site [chemical binding]; other site
449447005399	Q-loop/lid; other site
449447005400	ABC transporter signature motif; other site
449447005401	Walker B; other site
449447005402	D-loop; other site
449447005403	H-loop/switch region; other site
449447005404	ABC-2 type transporter; Region: ABC2_membrane; cl11417
449447005405	HEAT repeats; Region: HEAT_2; pfam13646
449447005406	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447005407	PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388
449447005408	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
449447005409	pyruvate kinase; Provisional; Region: PRK06354
449447005410	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
449447005411	domain interfaces; other site
449447005412	active site
449447005413	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
449447005414	S-layer homology domain; Region: SLH; pfam00395
449447005415	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
449447005416	Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444
449447005417	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
449447005418	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
449447005419	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
449447005420	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
449447005421	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
449447005422	active site
449447005423	nucleophile elbow; other site
449447005424	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862
449447005425	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
449447005426	ligand binding site; other site
449447005427	oligomer interface; other site
449447005428	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
449447005429	dimer interface [polypeptide binding]; other site
449447005430	N-terminal domain interface [polypeptide binding]; other site
449447005431	sulfate 1 binding site; other site
449447005432	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
449447005433	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
449447005434	FMN binding site [chemical binding]; other site
449447005435	active site
449447005436	catalytic residues [active]
449447005437	substrate binding site [chemical binding]; other site
449447005438	Domain of unknown function (DUF362); Region: DUF362; pfam04015
449447005439	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
449447005440	[2Fe-2S] cluster binding site [ion binding]; other site
449447005441	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
449447005442	Response regulator receiver domain; Region: Response_reg; pfam00072
449447005443	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447005444	active site
449447005445	phosphorylation site [posttranslational modification]
449447005446	intermolecular recognition site; other site
449447005447	dimerization interface [polypeptide binding]; other site
449447005448	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
449447005449	UGMP family protein; Validated; Region: PRK09604
449447005450	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
449447005451	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755
449447005452	PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573
449447005453	RNA binding site [nucleotide binding]; other site
449447005454	active site
449447005455	RNA polymerase Rpc34 subunit; Region: RNA_pol_Rpc34; cl02127
449447005456	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
449447005457	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
449447005458	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447005459	homodimer interface [polypeptide binding]; other site
449447005460	catalytic residue [active]
449447005461	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
449447005462	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
449447005463	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
449447005464	hydrolase, alpha/beta fold family protein; Region: PLN02679
449447005465	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
449447005466	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447005467	Helix-turn-helix domains; Region: HTH; cl00088
449447005468	Integrase core domain; Region: rve; cl01316
449447005469	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
449447005470	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
449447005471	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
449447005472	putative anticodon binding site; other site
449447005473	dimer interface [polypeptide binding]; other site
449447005474	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
449447005475	motif 1; other site
449447005476	active site
449447005477	motif 2; other site
449447005478	motif 3; other site
449447005479	KTSC domain; Region: KTSC; pfam13619
449447005480	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
449447005481	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447005482	active site
449447005483	phosphorylation site [posttranslational modification]
449447005484	intermolecular recognition site; other site
449447005485	dimerization interface [polypeptide binding]; other site
449447005486	Protein of unknown function (DUF3685); Region: DUF3685; pfam12452
449447005487	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
449447005488	metal binding site 2 [ion binding]; metal-binding site
449447005489	putative DNA binding helix; other site
449447005490	metal binding site 1 [ion binding]; metal-binding site
449447005491	dimer interface [polypeptide binding]; other site
449447005492	structural Zn2+ binding site [ion binding]; other site
449447005493	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447005494	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
449447005495	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447005496	active site
449447005497	phosphorylation site [posttranslational modification]
449447005498	intermolecular recognition site; other site
449447005499	dimerization interface [polypeptide binding]; other site
449447005500	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
449447005501	DNA binding site [nucleotide binding]
449447005502	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
449447005503	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
449447005504	Walker A/P-loop; other site
449447005505	ATP binding site [chemical binding]; other site
449447005506	Q-loop/lid; other site
449447005507	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
449447005508	ABC transporter signature motif; other site
449447005509	Walker B; other site
449447005510	D-loop; other site
449447005511	H-loop/switch region; other site
449447005512	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447005513	putative active site [active]
449447005514	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447005515	putative active site [active]
449447005516	FAD dependent oxidoreductase; Region: DAO; pfam01266
449447005517	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
449447005518	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
449447005519	active site
449447005520	HIGH motif; other site
449447005521	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
449447005522	KMSKS motif; other site
449447005523	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
449447005524	tRNA binding surface [nucleotide binding]; other site
449447005525	anticodon binding site; other site
449447005526	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447005527	ABC-ATPase subunit interface; other site
449447005528	NMT1-like family; Region: NMT1_2; cl15260
449447005529	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
449447005530	CHAD domain; Region: CHAD; cl10506
449447005531	bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500
449447005532	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
449447005533	active site
449447005534	dimer interface [polypeptide binding]; other site
449447005535	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
449447005536	active site
449447005537	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
449447005538	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
449447005539	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
449447005540	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
449447005541	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258
449447005542	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
449447005543	anti sigma factor interaction site; other site
449447005544	regulatory phosphorylation site [posttranslational modification]; other site
449447005545	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
449447005546	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
449447005547	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
449447005548	catalytic site [active]
449447005549	subunit interface [polypeptide binding]; other site
449447005550	Helix-turn-helix domains; Region: HTH; cl00088
449447005551	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
449447005552	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447005553	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447005554	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
449447005555	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447005556	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447005557	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447005558	V-type ATP synthase subunit I; Validated; Region: PRK05771
449447005559	Protein of unknown function (DUF2730); Region: DUF2730; pfam10805
449447005560	polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132
449447005561	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
449447005562	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447005563	active site
449447005564	ATP binding site [chemical binding]; other site
449447005565	substrate binding site [chemical binding]; other site
449447005566	activation loop (A-loop); other site
449447005567	RDD family; Region: RDD; cl00746
449447005568	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
449447005569	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
449447005570	active site residue [active]
449447005571	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
449447005572	Recombination protein O N terminal; Region: RecO_N; cl15812
449447005573	Recombination protein O C terminal; Region: RecO_C; pfam02565
449447005574	H+ Antiporter protein; Region: 2A0121; TIGR00900
449447005575	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
449447005576	putative substrate translocation pore; other site
449447005577	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
449447005578	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
449447005579	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
449447005580	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
449447005581	Calx-beta domain; Region: Calx-beta; cl02522
449447005582	Calx-beta domain; Region: Calx-beta; cl02522
449447005583	Calx-beta domain; Region: Calx-beta; cl02522
449447005584	Helix-turn-helix domains; Region: HTH; cl00088
449447005585	Winged helix-turn helix; Region: HTH_29; pfam13551
449447005586	Winged helix-turn helix; Region: HTH_33; pfam13592
449447005587	Integrase core domain; Region: rve; cl01316
449447005588	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447005589	Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042
449447005590	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
449447005591	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
449447005592	Dehydratase family; Region: ILVD_EDD; cl00340
449447005593	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447005594	binding surface
449447005595	Tetratricopeptide repeat; Region: TPR_16; pfam13432
449447005596	TPR motif; other site
449447005597	TPR repeat; Region: TPR_11; pfam13414
449447005598	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447005599	binding surface
449447005600	TPR repeat; Region: TPR_11; pfam13414
449447005601	TPR motif; other site
449447005602	TPR repeat; Region: TPR_11; pfam13414
449447005603	Ferritin-like domain; Region: Ferritin; pfam00210
449447005604	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
449447005605	dinuclear metal binding motif [ion binding]; other site
449447005606	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
449447005607	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
449447005608	putative ligand binding site [chemical binding]; other site
449447005609	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447005610	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
449447005611	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
449447005612	cofactor binding site; other site
449447005613	DNA binding site [nucleotide binding]
449447005614	substrate interaction site [chemical binding]; other site
449447005615	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447005616	Integrase core domain; Region: rve; cl01316
449447005617	Helix-turn-helix domains; Region: HTH; cl00088
449447005618	DNA binding site [nucleotide binding]
449447005619	Winged helix-turn helix; Region: HTH_29; pfam13551
449447005620	Helix-turn-helix domains; Region: HTH; cl00088
449447005621	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447005622	Transposase IS200 like; Region: Y1_Tnp; cl00848
449447005623	Helix-turn-helix domains; Region: HTH; cl00088
449447005624	Winged helix-turn helix; Region: HTH_29; pfam13551
449447005625	Helix-turn-helix domains; Region: HTH; cl00088
449447005626	Integrase core domain; Region: rve; cl01316
449447005627	Helix-turn-helix domains; Region: HTH; cl00088
449447005628	Helix-turn-helix domains; Region: HTH; cl00088
449447005629	Integrase core domain; Region: rve; cl01316
449447005630	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447005631	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447005632	putative active site [active]
449447005633	Vitamin K epoxide reductase family; Region: VKOR; cl01729
449447005634	Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI...; Region: PDI_a_family; cd02961
449447005635	catalytic residues [active]
449447005636	BtpA family; Region: BtpA; cl00440
449447005637	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
449447005638	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
449447005639	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447005640	FeS/SAM binding site; other site
449447005641	TRAM domain; Region: TRAM; cl01282
449447005642	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
449447005643	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
449447005644	ATP binding site [chemical binding]; other site
449447005645	Mg++ binding site [ion binding]; other site
449447005646	motif III; other site
449447005647	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
449447005648	nucleotide binding region [chemical binding]; other site
449447005649	ATP-binding site [chemical binding]; other site
449447005650	Protein of unknown function DUF262; Region: DUF262; cl14890
449447005651	Macrophage migration inhibitory factor (MIF); Region: MIF; pfam01187
449447005652	Predicted helicase [General function prediction only]; Region: COG4889
449447005653	Family description; Region: VCBS; pfam13517
449447005654	Family description; Region: VCBS; pfam13517
449447005655	Family description; Region: VCBS; pfam13517
449447005656	Family description; Region: VCBS; pfam13517
449447005657	Family description; Region: VCBS; pfam13517
449447005658	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
449447005659	iron-sulfur cluster [ion binding]; other site
449447005660	[2Fe-2S] cluster binding site [ion binding]; other site
449447005661	Family description; Region: VCBS; pfam13517
449447005662	Family description; Region: VCBS; pfam13517
449447005663	Family description; Region: VCBS; pfam13517
449447005664	Family description; Region: VCBS; pfam13517
449447005665	Family description; Region: VCBS; pfam13517
449447005666	Family description; Region: VCBS; pfam13517
449447005667	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
449447005668	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
449447005669	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
449447005670	active site
449447005671	dimer interface [polypeptide binding]; other site
449447005672	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
449447005673	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
449447005674	active site
449447005675	FMN binding site [chemical binding]; other site
449447005676	substrate binding site [chemical binding]; other site
449447005677	3Fe-4S cluster binding site [ion binding]; other site
449447005678	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
449447005679	domain interface; other site
449447005680	Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074
449447005681	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447005682	CoA-ligase; Region: Ligase_CoA; cl02894
449447005683	YGGT family; Region: YGGT; cl00508
449447005684	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
449447005685	proposed catalytic triad [active]
449447005686	active site nucleophile [active]
449447005687	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447005688	CsbD-like; Region: CsbD; cl15799
449447005689	CsbD-like; Region: CsbD; cl15799
449447005690	CsbD-like; Region: CsbD; cl15799
449447005691	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447005692	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447005693	Probable transposase; Region: OrfB_IS605; pfam01385
449447005694	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447005695	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
449447005696	BON domain; Region: BON; cl02771
449447005697	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
449447005698	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
449447005699	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447005700	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447005701	Helix-turn-helix domains; Region: HTH; cl00088
449447005702	Winged helix-turn helix; Region: HTH_29; pfam13551
449447005703	Winged helix-turn helix; Region: HTH_33; pfam13592
449447005704	Integrase core domain; Region: rve; cl01316
449447005705	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
449447005706	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
449447005707	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
449447005708	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447005709	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
449447005710	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447005711	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447005712	Probable transposase; Region: OrfB_IS605; pfam01385
449447005713	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447005714	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
449447005715	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
449447005716	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447005717	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
449447005718	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
449447005719	B12 binding site [chemical binding]; other site
449447005720	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447005721	FeS/SAM binding site; other site
449447005722	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
449447005723	RRXRR protein; Region: RRXRR; pfam14239
449447005724	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
449447005725	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
449447005726	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
449447005727	DXD motif; other site
449447005728	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447005729	MgtC family; Region: MgtC; pfam02308
449447005730	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447005731	Probable transposase; Region: OrfB_IS605; pfam01385
449447005732	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447005733	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447005734	Transposase domain (DUF772); Region: DUF772; cl15789
449447005735	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447005736	Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561
449447005737	Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_2; cd09821
449447005738	putative heme binding site [chemical binding]; other site
449447005739	putative substrate binding site [chemical binding]; other site
449447005740	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
449447005741	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447005742	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
449447005743	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
449447005744	active site
449447005745	dimer interface [polypeptide binding]; other site
449447005746	non-prolyl cis peptide bond; other site
449447005747	insertion regions; other site
449447005748	Transcriptional regulator [Transcription]; Region: LysR; COG0583
449447005749	Helix-turn-helix domains; Region: HTH; cl00088
449447005750	NMT1-like family; Region: NMT1_2; cl15260
449447005751	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
449447005752	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
449447005753	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
449447005754	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
449447005755	active site
449447005756	dimer interface [polypeptide binding]; other site
449447005757	non-prolyl cis peptide bond; other site
449447005758	insertion regions; other site
449447005759	Sodium:solute symporter family; Region: SSF; cl00456
449447005760	Protein of unknown function (DUF3098); Region: DUF3098; pfam11297
449447005761	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
449447005762	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
449447005763	Flavin binding site [chemical binding]; other site
449447005764	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
449447005765	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
449447005766	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
449447005767	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
449447005768	dimerization interface [polypeptide binding]; other site
449447005769	active site
449447005770	S-layer homology domain; Region: SLH; pfam00395
449447005771	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
449447005772	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
449447005773	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
449447005774	Flavin binding site [chemical binding]; other site
449447005775	Transposase IS200 like; Region: Y1_Tnp; cl00848
449447005776	ATP-grasp domain; Region: ATP-grasp_4; cl03087
449447005777	Double zinc ribbon; Region: DZR; pfam12773
449447005778	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
449447005779	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
449447005780	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
449447005781	NADP binding site [chemical binding]; other site
449447005782	active site
449447005783	putative substrate binding site [chemical binding]; other site
449447005784	GDP-mannose 4,6-dehydratase; Region: PLN02653
449447005785	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
449447005786	NADP-binding site; other site
449447005787	homotetramer interface [polypeptide binding]; other site
449447005788	substrate binding site [chemical binding]; other site
449447005789	homodimer interface [polypeptide binding]; other site
449447005790	active site
449447005791	uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792
449447005792	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
449447005793	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
449447005794	P-loop; other site
449447005795	Magnesium ion binding site [ion binding]; other site
449447005796	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
449447005797	Magnesium ion binding site [ion binding]; other site
449447005798	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
449447005799	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
449447005800	active site
449447005801	metal binding site [ion binding]; metal-binding site
449447005802	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237
449447005803	putative substrate binding pocket [chemical binding]; other site
449447005804	catalytic triad [active]
449447005805	AB domain interface; other site
449447005806	type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987
449447005807	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447005808	BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616
449447005809	Probable transposase; Region: OrfB_IS605; pfam01385
449447005810	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447005811	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447005812	Probable transposase; Region: OrfB_IS605; pfam01385
449447005813	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
449447005814	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
449447005815	catalytic residues [active]
449447005816	catalytic nucleophile [active]
449447005817	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
449447005818	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
449447005819	tRNA; other site
449447005820	putative tRNA binding site [nucleotide binding]; other site
449447005821	putative NADP binding site [chemical binding]; other site
449447005822	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
449447005823	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
449447005824	putative active site [active]
449447005825	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
449447005826	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
449447005827	active site
449447005828	metal binding site [ion binding]; metal-binding site
449447005829	Protein of unknown function (DUF2396); Region: DUF2396; cl09868
449447005830	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
449447005831	trimer interface [polypeptide binding]; other site
449447005832	putative metal binding site [ion binding]; other site
449447005833	Photosystem II protein Y (PsbY); Region: PsbY; cl05675
449447005834	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
449447005835	FAD binding domain; Region: FAD_binding_4; pfam01565
449447005836	adenylosuccinate lyase; Provisional; Region: PRK07380
449447005837	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
449447005838	tetramer interface [polypeptide binding]; other site
449447005839	active site
449447005840	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
449447005841	Helix-turn-helix domains; Region: HTH; cl00088
449447005842	Helix-turn-helix domains; Region: HTH; cl00088
449447005843	Integrase core domain; Region: rve; cl01316
449447005844	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447005845	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447005846	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
449447005847	non-specific DNA binding site [nucleotide binding]; other site
449447005848	salt bridge; other site
449447005849	sequence-specific DNA binding site [nucleotide binding]; other site
449447005850	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
449447005851	Predicted ATPase [General function prediction only]; Region: COG4637
449447005852	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
449447005853	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
449447005854	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
449447005855	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
449447005856	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
449447005857	Ion channel; Region: Ion_trans_2; cl11596
449447005858	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
449447005859	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447005860	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
449447005861	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
449447005862	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
449447005863	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
449447005864	Protein of unknown function (DUF497); Region: DUF497; cl01108
449447005865	Protein of unknown function (DUF433); Region: DUF433; cl01030
449447005866	tail fiber protein; Region: PHA00430
449447005867	Helix-turn-helix domains; Region: HTH; cl00088
449447005868	Winged helix-turn helix; Region: HTH_29; pfam13551
449447005869	Winged helix-turn helix; Region: HTH_33; pfam13592
449447005870	Integrase core domain; Region: rve; cl01316
449447005871	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447005872	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447005873	Transposase domain (DUF772); Region: DUF772; cl15789
449447005874	Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136
449447005875	Protein of unknown function (DUF433); Region: DUF433; cl01030
449447005876	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447005877	threonine dehydratase; Reviewed; Region: PRK09224
449447005878	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
449447005879	tetramer interface [polypeptide binding]; other site
449447005880	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447005881	catalytic residue [active]
449447005882	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
449447005883	putative Ile/Val binding site [chemical binding]; other site
449447005884	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
449447005885	putative Ile/Val binding site [chemical binding]; other site
449447005886	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
449447005887	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447005888	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
449447005889	aspartate aminotransferase; Provisional; Region: PRK05957
449447005890	aspartate aminotransferase; Provisional; Region: PRK05957
449447005891	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
449447005892	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447005893	homodimer interface [polypeptide binding]; other site
449447005894	catalytic residue [active]
449447005895	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447005896	structural tetrad; other site
449447005897	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
449447005898	HSP70 interaction site [polypeptide binding]; other site
449447005899	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
449447005900	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
449447005901	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
449447005902	protein binding site [polypeptide binding]; other site
449447005903	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
449447005904	ribosome recycling factor; Reviewed; Region: frr; PRK00083
449447005905	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
449447005906	hinge region; other site
449447005907	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
449447005908	putative nucleotide binding site [chemical binding]; other site
449447005909	uridine monophosphate binding site [chemical binding]; other site
449447005910	homohexameric interface [polypeptide binding]; other site
449447005911	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
449447005912	trimer interface [polypeptide binding]; other site
449447005913	active site
449447005914	dimer interface [polypeptide binding]; other site
449447005915	Rieske non-heme iron oxygenase (RO) family, Pheophorbide a oxygenase (PaO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of a small subfamily of enzymes found in plants as well as oxygenic...; Region: Rieske_RO_Alpha_PaO; cd03480
449447005916	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
449447005917	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
449447005918	hydrophobic ligand binding site; other site
449447005919	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
449447005920	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447005921	active site
449447005922	ATP binding site [chemical binding]; other site
449447005923	substrate binding site [chemical binding]; other site
449447005924	activation loop (A-loop); other site
449447005925	TPR repeat; Region: TPR_11; pfam13414
449447005926	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447005927	binding surface
449447005928	TPR motif; other site
449447005929	TPR repeat; Region: TPR_11; pfam13414
449447005930	TPR repeat; Region: TPR_11; pfam13414
449447005931	TPR repeat; Region: TPR_11; pfam13414
449447005932	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447005933	binding surface
449447005934	TPR motif; other site
449447005935	TPR repeat; Region: TPR_11; pfam13414
449447005936	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447005937	binding surface
449447005938	TPR motif; other site
449447005939	TPR repeat; Region: TPR_11; pfam13414
449447005940	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
449447005941	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
449447005942	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
449447005943	protein binding site [polypeptide binding]; other site
449447005944	WYL domain; Region: WYL; cl14852
449447005945	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447005946	CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158
449447005947	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
449447005948	active site
449447005949	NTP binding site [chemical binding]; other site
449447005950	metal binding triad [ion binding]; metal-binding site
449447005951	antibiotic binding site [chemical binding]; other site
449447005952	Protein of unknown function DUF86; Region: DUF86; cl01031
449447005953	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
449447005954	active site
449447005955	NTP binding site [chemical binding]; other site
449447005956	metal binding triad [ion binding]; metal-binding site
449447005957	antibiotic binding site [chemical binding]; other site
449447005958	Protein of unknown function DUF86; Region: DUF86; cl01031
449447005959	CRISPR/Cas system-associated protein Cas10d; Region: Cas10d_I-D; cd09712
449447005960	CRISPR type I-D/CYANO-associated protein Csc3/Cas10d; Region: cas_Csc3; TIGR03174
449447005961	CRISPR/Cas system-associated protein Csc2; Region: Csc2_I-D; cd09709
449447005962	CRISPR/Cas system-associated protein Csc1; Region: Csc1_I-D; cd09711
449447005963	WYL domain; Region: WYL; cl14852
449447005964	conserved hypothetical protein YmdA/YtgF; Region: YmdA_YtgF; TIGR03319
449447005965	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
449447005966	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447005967	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
449447005968	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447005969	putative active site [active]
449447005970	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447005971	putative active site [active]
449447005972	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
449447005973	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637
449447005974	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
449447005975	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
449447005976	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
449447005977	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
449447005978	Integrase core domain; Region: rve; cl01316
449447005979	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619
449447005980	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447005981	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
449447005982	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
449447005983	nudix motif; other site
449447005984	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
449447005985	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
449447005986	FtsX-like permease family; Region: FtsX; cl15850
449447005987	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
449447005988	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
449447005989	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
449447005990	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447005991	TPR motif; other site
449447005992	TPR repeat; Region: TPR_11; pfam13414
449447005993	binding surface
449447005994	TPR repeat; Region: TPR_11; pfam13414
449447005995	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447005996	binding surface
449447005997	TPR motif; other site
449447005998	TPR repeat; Region: TPR_11; pfam13414
449447005999	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447006000	TPR repeat; Region: TPR_11; pfam13414
449447006001	binding surface
449447006002	TPR motif; other site
449447006003	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447006004	Transposase domain (DUF772); Region: DUF772; cl15789
449447006005	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
449447006006	oligomeric interface; other site
449447006007	putative active site [active]
449447006008	homodimer interface [polypeptide binding]; other site
449447006009	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
449447006010	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
449447006011	active site
449447006012	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
449447006013	S-layer homology domain; Region: SLH; pfam00395
449447006014	S-layer homology domain; Region: SLH; pfam00395
449447006015	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
449447006016	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
449447006017	metal-binding site [ion binding]
449447006018	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
449447006019	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
449447006020	methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463
449447006021	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
449447006022	substrate binding site [chemical binding]; other site
449447006023	active site
449447006024	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
449447006025	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447006026	NAD(P) binding site [chemical binding]; other site
449447006027	active site
449447006028	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
449447006029	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
449447006030	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
449447006031	Walker A/P-loop; other site
449447006032	ATP binding site [chemical binding]; other site
449447006033	Q-loop/lid; other site
449447006034	ABC transporter signature motif; other site
449447006035	Walker B; other site
449447006036	D-loop; other site
449447006037	H-loop/switch region; other site
449447006038	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027
449447006039	Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265
449447006040	ligand-binding site [chemical binding]; other site
449447006041	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
449447006042	Tetratricopeptide repeat; Region: TPR_6; pfam13174
449447006043	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
449447006044	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
449447006045	N-acetyl-D-glucosamine binding site [chemical binding]; other site
449447006046	catalytic residue [active]
449447006047	Cobalt transport protein; Region: CbiQ; cl00463
449447006048	dephospho-CoA kinase; Region: TIGR00152
449447006049	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
449447006050	CoA-binding site [chemical binding]; other site
449447006051	ATP-binding [chemical binding]; other site
449447006052	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
449447006053	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
449447006054	ATP binding site [chemical binding]; other site
449447006055	active site
449447006056	substrate binding site [chemical binding]; other site
449447006057	Helix-turn-helix domains; Region: HTH; cl00088
449447006058	Winged helix-turn helix; Region: HTH_29; pfam13551
449447006059	Winged helix-turn helix; Region: HTH_33; pfam13592
449447006060	Integrase core domain; Region: rve; cl01316
449447006061	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
449447006062	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
449447006063	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
449447006064	active site
449447006065	dimer interface [polypeptide binding]; other site
449447006066	motif 1; other site
449447006067	motif 2; other site
449447006068	motif 3; other site
449447006069	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
449447006070	anticodon binding site; other site
449447006071	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
449447006072	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
449447006073	metal binding site [ion binding]; metal-binding site
449447006074	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
449447006075	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447006076	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
449447006077	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
449447006078	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
449447006079	Zn binding site [ion binding]; other site
449447006080	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
449447006081	Predicted ATPase [General function prediction only]; Region: COG4637
449447006082	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447006083	Immunoglobulin domain; Region: Ig; cl11960
449447006084	Part of the ABC transporter complex cysAWTP involved in sulfate import.  Responsible for energy coupling to the transport system.  The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296
449447006085	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
449447006086	Walker A/P-loop; other site
449447006087	ATP binding site [chemical binding]; other site
449447006088	Q-loop/lid; other site
449447006089	ABC transporter signature motif; other site
449447006090	Walker B; other site
449447006091	D-loop; other site
449447006092	H-loop/switch region; other site
449447006093	TOBE domain; Region: TOBE_2; cl01440
449447006094	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447006095	dimer interface [polypeptide binding]; other site
449447006096	conserved gate region; other site
449447006097	putative PBP binding loops; other site
449447006098	ABC-ATPase subunit interface; other site
449447006099	sulfate transport protein; Provisional; Region: cysT; CHL00187
449447006100	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447006101	dimer interface [polypeptide binding]; other site
449447006102	conserved gate region; other site
449447006103	putative PBP binding loops; other site
449447006104	ABC-ATPase subunit interface; other site
449447006105	NIL domain; Region: NIL; cl09633
449447006106	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
449447006107	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
449447006108	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
449447006109	Helix-turn-helix domains; Region: HTH; cl00088
449447006110	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
449447006111	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
449447006112	dimerization interface [polypeptide binding]; other site
449447006113	active site
449447006114	metal binding site [ion binding]; metal-binding site
449447006115	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
449447006116	dsRNA binding site [nucleotide binding]; other site
449447006117	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
449447006118	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
449447006119	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
449447006120	active site
449447006121	dimer interface [polypeptide binding]; other site
449447006122	motif 1; other site
449447006123	motif 2; other site
449447006124	motif 3; other site
449447006125	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
449447006126	anticodon binding site; other site
449447006127	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
449447006128	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447006129	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
449447006130	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447006131	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447006132	Transposase [DNA replication, recombination, and repair]; Region: COG5433
449447006133	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
449447006134	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
449447006135	active site
449447006136	metal binding site [ion binding]; metal-binding site
449447006137	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
449447006138	metal binding site [ion binding]; metal-binding site
449447006139	tocopherol O-methyltransferase; Region: PLN02244
449447006140	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447006141	S-adenosylmethionine binding site [chemical binding]; other site
449447006142	Helix-turn-helix domains; Region: HTH; cl00088
449447006143	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
449447006144	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
449447006145	G1 box; other site
449447006146	GTP/Mg2+ binding site [chemical binding]; other site
449447006147	Switch I region; other site
449447006148	G2 box; other site
449447006149	G3 box; other site
449447006150	Switch II region; other site
449447006151	G4 box; other site
449447006152	G5 box; other site
449447006153	Nucleoside recognition; Region: Gate; cl00486
449447006154	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
449447006155	FeoA domain; Region: FeoA; cl00838
449447006156	FeoA domain; Region: FeoA; cl00838
449447006157	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
449447006158	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447006159	dimer interface [polypeptide binding]; other site
449447006160	phosphorylation site [posttranslational modification]
449447006161	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447006162	ATP binding site [chemical binding]; other site
449447006163	Mg2+ binding site [ion binding]; other site
449447006164	G-X-G motif; other site
449447006165	Response regulator receiver domain; Region: Response_reg; pfam00072
449447006166	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447006167	active site
449447006168	phosphorylation site [posttranslational modification]
449447006169	intermolecular recognition site; other site
449447006170	dimerization interface [polypeptide binding]; other site
449447006171	KaiA domain; Region: KaiA; pfam07688
449447006172	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
449447006173	tetramer interface [polypeptide binding]; other site
449447006174	dimer interface [polypeptide binding]; other site
449447006175	circadian clock protein KaiC; Reviewed; Region: PRK09302
449447006176	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
449447006177	Walker A motif; other site
449447006178	ATP binding site [chemical binding]; other site
449447006179	Walker B motif; other site
449447006180	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447006181	ATP binding site [chemical binding]; other site
449447006182	Walker B motif; other site
449447006183	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
449447006184	Sulfotransferase family; Region: Sulfotransfer_3; cl14559
449447006185	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
449447006186	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
449447006187	inhibitor-cofactor binding pocket; inhibition site
449447006188	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447006189	catalytic residue [active]
449447006190	Photosystem I reaction centre subunit IV / PsaE; Region: PSI_PsaE; cl03585
449447006191	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611
449447006192	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
449447006193	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447006194	Walker A/P-loop; other site
449447006195	ATP binding site [chemical binding]; other site
449447006196	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
449447006197	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447006198	ABC transporter signature motif; other site
449447006199	Walker B; other site
449447006200	D-loop; other site
449447006201	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
449447006202	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
449447006203	arginine-tRNA ligase; Region: PLN02286
449447006204	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104
449447006205	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
449447006206	active site
449447006207	HIGH motif; other site
449447006208	KMSK motif region; other site
449447006209	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
449447006210	tRNA binding surface [nucleotide binding]; other site
449447006211	anticodon binding site; other site
449447006212	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
449447006213	YcfA-like protein; Region: YcfA; cl00752
449447006214	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
449447006215	homotrimer interaction site [polypeptide binding]; other site
449447006216	zinc binding site [ion binding]; other site
449447006217	CDP-binding sites; other site
449447006218	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
449447006219	Predicted ATPase [General function prediction only]; Region: COG4637
449447006220	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447006221	Immunoglobulin domain; Region: Ig; cl11960
449447006222	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902
449447006223	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447006224	ATP binding site [chemical binding]; other site
449447006225	putative Mg++ binding site [ion binding]; other site
449447006226	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
449447006227	Predicted helicase [General function prediction only]; Region: COG4889
449447006228	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
449447006229	Photosystem I psaG / psaK; Region: PSI_PSAK; cl11425
449447006230	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
449447006231	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447006232	putative PBP binding loops; other site
449447006233	dimer interface [polypeptide binding]; other site
449447006234	ABC-ATPase subunit interface; other site
449447006235	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
449447006236	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447006237	Domain of unknown function (DUF697); Region: DUF697; cl12064
449447006238	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
449447006239	active site
449447006240	catalytic motif [active]
449447006241	Zn binding site [ion binding]; other site
449447006242	Helix-turn-helix domains; Region: HTH; cl00088
449447006243	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
449447006244	Divergent AAA domain; Region: AAA_4; pfam04326
449447006245	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
449447006246	FAD dependent oxidoreductase; Region: DAO; pfam01266
449447006247	Tic20-like protein; Region: Tic20; pfam09685
449447006248	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
449447006249	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
449447006250	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
449447006251	dimer interface [polypeptide binding]; other site
449447006252	motif 1; other site
449447006253	active site
449447006254	motif 2; other site
449447006255	motif 3; other site
449447006256	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447006257	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
449447006258	RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590
449447006259	RNA/DNA binding site [nucleotide binding]; other site
449447006260	RRM dimerization site [polypeptide binding]; other site
449447006261	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
449447006262	DHH family; Region: DHH; pfam01368
449447006263	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_8; cd04621
449447006264	FOG: CBS domain [General function prediction only]; Region: COG0517
449447006265	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
449447006266	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
449447006267	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
449447006268	active site
449447006269	NTP binding site [chemical binding]; other site
449447006270	metal binding triad [ion binding]; metal-binding site
449447006271	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
449447006272	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
449447006273	YCF9; Region: Ycf9; cl09269
449447006274	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
449447006275	homopentamer interface [polypeptide binding]; other site
449447006276	active site
449447006277	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447006278	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447006279	Probable transposase; Region: OrfB_IS605; pfam01385
449447006280	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447006281	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
449447006282	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
449447006283	putative catalytic cysteine [active]
449447006284	Permease; Region: Permease; cl00510
449447006285	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447006286	Helix-turn-helix domains; Region: HTH; cl00088
449447006287	Integrase core domain; Region: rve; cl01316
449447006288	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376
449447006289	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
449447006290	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
449447006291	NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010
449447006292	Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279
449447006293	active site
449447006294	Preprotein translocase SecG subunit; Region: SecG; cl09123
449447006295	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
449447006296	Sulfatase; Region: Sulfatase; cl10460
449447006297	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
449447006298	dimerization interface [polypeptide binding]; other site
449447006299	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
449447006300	Domain of unknown function (DUF4415); Region: DUF4415; cl01401
449447006301	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
449447006302	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
449447006303	RNA binding surface [nucleotide binding]; other site
449447006304	Bifunctional nuclease; Region: DNase-RNase; cl00553
449447006305	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
449447006306	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
449447006307	active site
449447006308	catalytic tetrad [active]
449447006309	hypothetical protein; Provisional; Region: PRK08185
449447006310	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
449447006311	intersubunit interface [polypeptide binding]; other site
449447006312	active site
449447006313	zinc binding site [ion binding]; other site
449447006314	Na+ binding site [ion binding]; other site
449447006315	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
449447006316	C-terminal peptidase (prc); Region: prc; TIGR00225
449447006317	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
449447006318	protein binding site [polypeptide binding]; other site
449447006319	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
449447006320	Catalytic dyad [active]
449447006321	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
449447006322	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346
449447006323	putative ligand binding site [chemical binding]; other site
449447006324	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447006325	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447006326	Probable transposase; Region: OrfB_IS605; pfam01385
449447006327	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447006328	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447006329	Protein of unknown function (DUF433); Region: DUF433; cl01030
449447006330	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
449447006331	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447006332	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447006333	hypothetical protein; Validated; Region: PRK07411
449447006334	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
449447006335	ATP binding site [chemical binding]; other site
449447006336	substrate interface [chemical binding]; other site
449447006337	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
449447006338	active site residue [active]
449447006339	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
449447006340	lipoyl attachment site [posttranslational modification]; other site
449447006341	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
449447006342	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447006343	CoA-ligase; Region: Ligase_CoA; cl02894
449447006344	ATP-grasp domain; Region: ATP-grasp_4; cl03087
449447006345	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
449447006346	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
449447006347	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
449447006348	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447006349	NAD(P) binding site [chemical binding]; other site
449447006350	active site
449447006351	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447006352	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
449447006353	putative ADP-binding pocket [chemical binding]; other site
449447006354	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447006355	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
449447006356	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
449447006357	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447006358	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447006359	S-adenosylmethionine binding site [chemical binding]; other site
449447006360	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
449447006361	metal-binding site
449447006362	Transposase domain (DUF772); Region: DUF772; cl15789
449447006363	Transposase domain (DUF772); Region: DUF772; cl15789
449447006364	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447006365	Transposase domain (DUF772); Region: DUF772; cl15789
449447006366	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447006367	putative active site [active]
449447006368	Protein of unknown function (DUF433); Region: DUF433; cl01030
449447006369	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
449447006370	Helix-turn-helix domains; Region: HTH; cl00088
449447006371	DNA binding site [nucleotide binding]
449447006372	Winged helix-turn helix; Region: HTH_29; pfam13551
449447006373	Helix-turn-helix domains; Region: HTH; cl00088
449447006374	Integrase core domain; Region: rve; cl01316
449447006375	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447006376	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
449447006377	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447006378	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447006379	NAD(P) binding site [chemical binding]; other site
449447006380	active site
449447006381	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
449447006382	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
449447006383	MatE; Region: MatE; cl10513
449447006384	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
449447006385	Putative capsular polysaccharide synthesis protein; Region: NKWYS; pfam10364
449447006386	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
449447006387	Chain length determinant protein; Region: Wzz; cl15801
449447006388	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
449447006389	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
449447006390	Nucleotide binding site [chemical binding]; other site
449447006391	P loop; other site
449447006392	DTAP/Switch II; other site
449447006393	Switch I; other site
449447006394	cryptochrome, DASH family; Region: crypto_DASH; TIGR02765
449447006395	DNA photolyase; Region: DNA_photolyase; pfam00875
449447006396	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
449447006397	Quinolinate synthetase A protein; Region: NadA; cl00420
449447006398	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
449447006399	Photosystem II protein; Region: PSII; cl08223
449447006400	PsbJ; Region: PsbJ; cl09469
449447006401	PsbL protein; Region: PsbL; cl03581
449447006402	Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; cl02834
449447006403	cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557
449447006404	Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; cl02834
449447006405	Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284
449447006406	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
449447006407	Rubredoxin; Region: Rubredoxin; pfam00301
449447006408	iron binding site [ion binding]; other site
449447006409	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
449447006410	Helix-turn-helix domains; Region: HTH; cl00088
449447006411	Winged helix-turn helix; Region: HTH_29; pfam13551
449447006412	Winged helix-turn helix; Region: HTH_33; pfam13592
449447006413	Integrase core domain; Region: rve; cl01316
449447006414	MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816
449447006415	YcaO-like family; Region: YcaO; pfam02624
449447006416	Uncharacterized conserved protein [Function unknown]; Region: COG1944; cl09146
449447006417	Mannan-binding protein; Region: MVL; pfam12151
449447006418	Mannan-binding protein; Region: MVL; pfam12151
449447006419	Uncharacterized conserved protein [Function unknown]; Region: COG1944; cl09146
449447006420	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
449447006421	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
449447006422	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
449447006423	putative active site [active]
449447006424	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
449447006425	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
449447006426	Transposase; Region: DEDD_Tnp_IS110; pfam01548
449447006427	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
449447006428	Protein of unknown function (DUF497); Region: DUF497; cl01108
449447006429	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447006430	Transposase domain (DUF772); Region: DUF772; cl15789
449447006431	Domain of unknown function (DUF4415); Region: DUF4415; cl01401
449447006432	Protein of unknown function (DUF497); Region: DUF497; cl01108
449447006433	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
449447006434	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
449447006435	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
449447006436	active site
449447006437	Helix-turn-helix domains; Region: HTH; cl00088
449447006438	Winged helix-turn helix; Region: HTH_29; pfam13551
449447006439	Winged helix-turn helix; Region: HTH_33; pfam13592
449447006440	Integrase core domain; Region: rve; cl01316
449447006441	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
449447006442	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
449447006443	putative active site [active]
449447006444	putative NTP binding site [chemical binding]; other site
449447006445	putative nucleic acid binding site [nucleotide binding]; other site
449447006446	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
449447006447	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
449447006448	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
449447006449	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
449447006450	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447006451	active site
449447006452	ATP binding site [chemical binding]; other site
449447006453	substrate binding site [chemical binding]; other site
449447006454	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
449447006455	substrate binding site [chemical binding]; other site
449447006456	activation loop (A-loop); other site
449447006457	activation loop (A-loop); other site
449447006458	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447006459	Predicted ATPase [General function prediction only]; Region: COG3899
449447006460	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
449447006461	GAF domain; Region: GAF; cl15785
449447006462	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
449447006463	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
449447006464	putative metal binding site; other site
449447006465	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447006466	binding surface
449447006467	TPR repeat; Region: TPR_11; pfam13414
449447006468	TPR motif; other site
449447006469	TPR repeat; Region: TPR_11; pfam13414
449447006470	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447006471	binding surface
449447006472	TPR motif; other site
449447006473	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
449447006474	dimerization interface [polypeptide binding]; other site
449447006475	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
449447006476	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
449447006477	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
449447006478	dimer interface [polypeptide binding]; other site
449447006479	putative CheW interface [polypeptide binding]; other site
449447006480	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
449447006481	Response regulator receiver domain; Region: Response_reg; pfam00072
449447006482	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447006483	active site
449447006484	phosphorylation site [posttranslational modification]
449447006485	intermolecular recognition site; other site
449447006486	dimerization interface [polypeptide binding]; other site
449447006487	Probable transposase; Region: OrfB_IS605; pfam01385
449447006488	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447006489	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
449447006490	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
449447006491	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
449447006492	substrate binding pocket [chemical binding]; other site
449447006493	substrate-Mg2+ binding site; other site
449447006494	aspartate-rich region 1; other site
449447006495	aspartate-rich region 2; other site
449447006496	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
449447006497	interchain domain interface [polypeptide binding]; other site
449447006498	intrachain domain interface; other site
449447006499	Qi binding site; other site
449447006500	Qo binding site; other site
449447006501	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
449447006502	Qi binding site; other site
449447006503	intrachain domain interface; other site
449447006504	interchain domain interface [polypeptide binding]; other site
449447006505	heme bH binding site [chemical binding]; other site
449447006506	heme bL binding site [chemical binding]; other site
449447006507	Qo binding site; other site
449447006508	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447006509	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447006510	Probable transposase; Region: OrfB_IS605; pfam01385
449447006511	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447006512	Uncharacterized conserved protein [Function unknown]; Region: COG2308
449447006513	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503
449447006514	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503
449447006515	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980
449447006516	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
449447006517	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
449447006518	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447006519	Probable transposase; Region: OrfB_IS605; pfam01385
449447006520	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447006521	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447006522	Transposase domain (DUF772); Region: DUF772; cl15789
449447006523	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447006524	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
449447006525	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
449447006526	Protein of unknown function (DUF456); Region: DUF456; cl01069
449447006527	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
449447006528	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
449447006529	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
449447006530	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
449447006531	cofactor binding site; other site
449447006532	DNA binding site [nucleotide binding]
449447006533	substrate interaction site [chemical binding]; other site
449447006534	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447006535	Probable transposase; Region: OrfB_IS605; pfam01385
449447006536	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447006537	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447006538	Transposase IS200 like; Region: Y1_Tnp; cl00848
449447006539	Transposase IS200 like; Region: Y1_Tnp; cl00848
449447006540	Peptidase family M48; Region: Peptidase_M48; cl12018
449447006541	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
449447006542	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
449447006543	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
449447006544	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
449447006545	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
449447006546	NAD(P) binding site [chemical binding]; other site
449447006547	homotetramer interface [polypeptide binding]; other site
449447006548	homodimer interface [polypeptide binding]; other site
449447006549	active site
449447006550	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
449447006551	putative acyl-acceptor binding pocket; other site
449447006552	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447006553	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
449447006554	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447006555	S-adenosylmethionine binding site [chemical binding]; other site
449447006556	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
449447006557	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
449447006558	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
449447006559	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
449447006560	serine O-acetyltransferase; Region: cysE; TIGR01172
449447006561	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
449447006562	trimer interface [polypeptide binding]; other site
449447006563	active site
449447006564	substrate binding site [chemical binding]; other site
449447006565	CoA binding site [chemical binding]; other site
449447006566	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
449447006567	Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017
449447006568	Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025
449447006569	active site
449447006570	catalytic residues [active]
449447006571	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
449447006572	Haemolytic domain; Region: Haemolytic; cl00506
449447006573	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
449447006574	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
449447006575	DNA binding site [nucleotide binding]
449447006576	Int/Topo IB signature motif; other site
449447006577	active site
449447006578	catalytic residues [active]
449447006579	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447006580	Integrase core domain; Region: rve; cl01316
449447006581	Helix-turn-helix domains; Region: HTH; cl00088
449447006582	DNA binding site [nucleotide binding]
449447006583	Winged helix-turn helix; Region: HTH_29; pfam13551
449447006584	Helix-turn-helix domains; Region: HTH; cl00088
449447006585	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447006586	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447006587	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447006588	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447006589	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447006590	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
449447006591	non-specific DNA binding site [nucleotide binding]; other site
449447006592	salt bridge; other site
449447006593	sequence-specific DNA binding site [nucleotide binding]; other site
449447006594	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
449447006595	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
449447006596	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
449447006597	active site
449447006598	metal binding site [ion binding]; metal-binding site
449447006599	Helix-turn-helix domains; Region: HTH; cl00088
449447006600	Winged helix-turn helix; Region: HTH_29; pfam13551
449447006601	Winged helix-turn helix; Region: HTH_33; pfam13592
449447006602	Integrase core domain; Region: rve; cl01316
449447006603	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447006604	Transposase domain (DUF772); Region: DUF772; cl15789
449447006605	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
449447006606	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
449447006607	Integrase core domain; Region: rve; cl01316
449447006608	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
449447006609	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
449447006610	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447006611	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447006612	Transposase [DNA replication, recombination, and repair]; Region: COG5433
449447006613	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447006614	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447006615	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447006616	Transposase domain (DUF772); Region: DUF772; cl15789
449447006617	Transposase [DNA replication, recombination, and repair]; Region: COG5433
449447006618	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447006619	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447006620	Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276
449447006621	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
449447006622	C-terminal domain interface [polypeptide binding]; other site
449447006623	active site
449447006624	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
449447006625	active site
449447006626	N-terminal domain interface [polypeptide binding]; other site
449447006627	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447006628	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447006629	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
449447006630	non-specific DNA binding site [nucleotide binding]; other site
449447006631	salt bridge; other site
449447006632	sequence-specific DNA binding site [nucleotide binding]; other site
449447006633	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447006634	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
449447006635	PemK-like protein; Region: PemK; cl00995
449447006636	PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874
449447006637	putative active site [active]
449447006638	omega-6 fatty acid desaturase; Region: PLN02505
449447006639	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
449447006640	putative di-iron ligands [ion binding]; other site
449447006641	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
449447006642	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
449447006643	cofactor binding site; other site
449447006644	DNA binding site [nucleotide binding]
449447006645	substrate interaction site [chemical binding]; other site
449447006646	Helix-turn-helix domains; Region: HTH; cl00088
449447006647	Winged helix-turn helix; Region: HTH_29; pfam13551
449447006648	Winged helix-turn helix; Region: HTH_33; pfam13592
449447006649	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
449447006650	Integrase core domain; Region: rve; cl01316
449447006651	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
449447006652	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447006653	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447006654	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447006655	G1 box; other site
449447006656	Walker A/P-loop; other site
449447006657	GTP/Mg2+ binding site [chemical binding]; other site
449447006658	ATP binding site [chemical binding]; other site
449447006659	G2 box; other site
449447006660	Switch I region; other site
449447006661	G3 box; other site
449447006662	Switch II region; other site
449447006663	G4 box; other site
449447006664	Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136
449447006665	Protein of unknown function (DUF433); Region: DUF433; cl01030
449447006666	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
449447006667	Protein of unknown function (DUF433); Region: DUF433; cl01030
449447006668	Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136
449447006669	putative phosphoketolase; Provisional; Region: PRK05261
449447006670	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
449447006671	TPP-binding site; other site
449447006672	D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894
449447006673	XFP C-terminal domain; Region: XFP_C; pfam09363
449447006674	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447006675	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
449447006676	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
449447006677	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
449447006678	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
449447006679	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
449447006680	NAD synthetase; Provisional; Region: PRK13981
449447006681	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
449447006682	multimer interface [polypeptide binding]; other site
449447006683	active site
449447006684	catalytic triad [active]
449447006685	protein interface 1 [polypeptide binding]; other site
449447006686	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
449447006687	homodimer interface [polypeptide binding]; other site
449447006688	NAD binding pocket [chemical binding]; other site
449447006689	ATP binding pocket [chemical binding]; other site
449447006690	Mg binding site [ion binding]; other site
449447006691	active-site loop [active]
449447006692	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
449447006693	nudix motif; other site
449447006694	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
449447006695	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
449447006696	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
449447006697	active site
449447006698	(T/H)XGH motif; other site
449447006699	RES domain; Region: RES; cl02411
449447006700	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
449447006701	HEAT repeats; Region: HEAT_2; pfam13646
449447006702	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
449447006703	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
449447006704	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447006705	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447006706	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447006707	putative active site [active]
449447006708	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447006709	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
449447006710	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447006711	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447006712	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
449447006713	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
449447006714	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
449447006715	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
449447006716	active site
449447006717	catalytic site [active]
449447006718	enolase; Provisional; Region: eno; PRK00077
449447006719	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
449447006720	dimer interface [polypeptide binding]; other site
449447006721	metal binding site [ion binding]; metal-binding site
449447006722	substrate binding pocket [chemical binding]; other site
449447006723	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447006724	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447006725	Probable transposase; Region: OrfB_IS605; pfam01385
449447006726	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447006727	Proteolipid membrane potential modulator; Region: Pmp3; cl00431
449447006728	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
449447006729	Rrf2 family protein; Region: rrf2_super; TIGR00738
449447006730	Helix-turn-helix domains; Region: HTH; cl00088
449447006731	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
449447006732	CobD/Cbib protein; Region: CobD_Cbib; cl00561
449447006733	Transposase domain (DUF772); Region: DUF772; cl15789
449447006734	Transposase domain (DUF772); Region: DUF772; cl15789
449447006735	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
449447006736	putative acyl-acceptor binding pocket; other site
449447006737	Helix-turn-helix domains; Region: HTH; cl00088
449447006738	DNA binding site [nucleotide binding]
449447006739	Winged helix-turn helix; Region: HTH_29; pfam13551
449447006740	Helix-turn-helix domains; Region: HTH; cl00088
449447006741	Integrase core domain; Region: rve; cl01316
449447006742	Integrase core domain; Region: rve; cl01316
449447006743	Winged helix-turn helix; Region: HTH_29; pfam13551
449447006744	Helix-turn-helix domains; Region: HTH; cl00088
449447006745	Winged helix-turn helix; Region: HTH_29; pfam13551
449447006746	Helix-turn-helix domains; Region: HTH; cl00088
449447006747	Helix-turn-helix domains; Region: HTH; cl00088
449447006748	Integrase core domain; Region: rve; cl01316
449447006749	aspartate aminotransferase; Provisional; Region: PRK05764
449447006750	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
449447006751	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447006752	homodimer interface [polypeptide binding]; other site
449447006753	catalytic residue [active]
449447006754	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
449447006755	Helix-turn-helix domains; Region: HTH; cl00088
449447006756	Helix-turn-helix domains; Region: HTH; cl00088
449447006757	Integrase core domain; Region: rve; cl01316
449447006758	ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]; Region: RPT1; COG1222
449447006759	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447006760	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
449447006761	Helix-turn-helix domains; Region: HTH; cl00088
449447006762	Helix-turn-helix domains; Region: HTH; cl00088
449447006763	Integrase core domain; Region: rve; cl01316
449447006764	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447006765	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447006766	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447006767	Transposase [DNA replication, recombination, and repair]; Region: COG5433
449447006768	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
449447006769	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
449447006770	putative tRNA-binding site [nucleotide binding]; other site
449447006771	B3/4 domain; Region: B3_4; cl11458
449447006772	tRNA synthetase B5 domain; Region: B5; cl08394
449447006773	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
449447006774	dimer interface [polypeptide binding]; other site
449447006775	motif 1; other site
449447006776	motif 3; other site
449447006777	motif 2; other site
449447006778	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386
449447006779	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447006780	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
449447006781	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
449447006782	ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261
449447006783	Walker A/P-loop; other site
449447006784	ATP binding site [chemical binding]; other site
449447006785	Q-loop/lid; other site
449447006786	ABC transporter signature motif; other site
449447006787	Walker B; other site
449447006788	D-loop; other site
449447006789	H-loop/switch region; other site
449447006790	Substrate binding subunit of ER-derived-lipid transporter; Provisional; Region: PLN03094
449447006791	mce related protein; Region: MCE; pfam02470
449447006792	Substrate binding subunit of ER-derived-lipid transporter; Provisional; Region: PLN03094
449447006793	Protein of unknown function (DUF433); Region: DUF433; cl01030
449447006794	hypothetical protein; Provisional; Region: PLN03089
449447006795	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447006796	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447006797	structural tetrad; other site
449447006798	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447006799	putative active site [active]
449447006800	UbiA prenyltransferase family; Region: UbiA; cl00337
449447006801	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
449447006802	HerA helicase [Replication, recombination, and repair]; Region: COG0433
449447006803	Domain of unknown function DUF87; Region: DUF87; pfam01935
449447006804	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447006805	TRAM domain; Region: TRAM; cl01282
449447006806	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
449447006807	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447006808	S-adenosylmethionine binding site [chemical binding]; other site
449447006809	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
449447006810	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
449447006811	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
449447006812	EamA-like transporter family; Region: EamA; cl01037
449447006813	EamA-like transporter family; Region: EamA; cl01037
449447006814	Domain of unknown function (DUF1823); Region: DUF1823; pfam08853
449447006815	CO2 hydration protein (ChpXY); Region: ChpXY; cl10905
449447006816	GUN4-like; Region: GUN4; pfam05419
449447006817	Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890
449447006818	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
449447006819	putative substrate translocation pore; other site
449447006820	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
449447006821	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
449447006822	dimer interface [polypeptide binding]; other site
449447006823	decamer (pentamer of dimers) interface [polypeptide binding]; other site
449447006824	catalytic triad [active]
449447006825	peroxidatic and resolving cysteines [active]
449447006826	Helix-turn-helix domains; Region: HTH; cl00088
449447006827	Winged helix-turn helix; Region: HTH_29; pfam13551
449447006828	Winged helix-turn helix; Region: HTH_33; pfam13592
449447006829	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
449447006830	ligand binding site [chemical binding]; other site
449447006831	flexible hinge region; other site
449447006832	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
449447006833	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39B; cd02418
449447006834	putative active site [active]
449447006835	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
449447006836	MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1.  In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249
449447006837	Walker A/P-loop; other site
449447006838	ATP binding site [chemical binding]; other site
449447006839	Q-loop/lid; other site
449447006840	ABC transporter signature motif; other site
449447006841	Walker B; other site
449447006842	D-loop; other site
449447006843	H-loop/switch region; other site
449447006844	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
449447006845	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
449447006846	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
449447006847	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
449447006848	PPIC-type PPIASE domain; Region: Rotamase; cl08278
449447006849	YokU-like protein; Region: YokU; cl15819
449447006850	Transposase; Region: DEDD_Tnp_IS110; pfam01548
449447006851	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
449447006852	YokU-like protein; Region: YokU; cl15819
449447006853	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447006854	YokU-like protein; Region: YokU; cl15819
449447006855	TPR repeat; Region: TPR_11; pfam13414
449447006856	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447006857	binding surface
449447006858	TPR motif; other site
449447006859	Photosystem I psaG / psaK; Region: PSI_PSAK; cl11425
449447006860	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405
449447006861	active site
449447006862	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
449447006863	homodecamer interface [polypeptide binding]; other site
449447006864	GTP cyclohydrolase I; Provisional; Region: PLN03044
449447006865	active site
449447006866	putative catalytic site residues [active]
449447006867	zinc binding site [ion binding]; other site
449447006868	GTP-CH-I/GFRP interaction surface; other site
449447006869	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
449447006870	classical (c) SDRs; Region: SDR_c; cd05233
449447006871	NAD(P) binding site [chemical binding]; other site
449447006872	active site
449447006873	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
449447006874	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
449447006875	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
449447006876	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447006877	dimer interface [polypeptide binding]; other site
449447006878	phosphorylation site [posttranslational modification]
449447006879	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447006880	ATP binding site [chemical binding]; other site
449447006881	Mg2+ binding site [ion binding]; other site
449447006882	G-X-G motif; other site
449447006883	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
449447006884	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447006885	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
449447006886	putative ADP-binding pocket [chemical binding]; other site
449447006887	CemA family; Region: CemA; cl03855
449447006888	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
449447006889	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
449447006890	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
449447006891	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
449447006892	Walker A/P-loop; other site
449447006893	ATP binding site [chemical binding]; other site
449447006894	Q-loop/lid; other site
449447006895	ABC transporter signature motif; other site
449447006896	Walker B; other site
449447006897	D-loop; other site
449447006898	H-loop/switch region; other site
449447006899	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447006900	Uncharacterized conserved protein [Function unknown]; Region: COG4748
449447006901	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
449447006902	Integrase core domain; Region: rve; cl01316
449447006903	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
449447006904	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
449447006905	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
449447006906	active site
449447006907	Nodulation protein Z (NodZ); Region: NodZ; pfam05830
449447006908	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
449447006909	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447006910	Probable transposase; Region: OrfB_IS605; pfam01385
449447006911	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447006912	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
449447006913	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
449447006914	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
449447006915	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
449447006916	substrate binding pocket [chemical binding]; other site
449447006917	membrane-bound complex binding site; other site
449447006918	hinge residues; other site
449447006919	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447006920	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447006921	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447006922	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447006923	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447006924	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447006925	Helix-turn-helix domains; Region: HTH; cl00088
449447006926	Integrase core domain; Region: rve; cl01316
449447006927	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447006928	Helix-turn-helix domains; Region: HTH; cl00088
449447006929	Winged helix-turn helix; Region: HTH_29; pfam13551
449447006930	Helix-turn-helix domains; Region: HTH; cl00088
449447006931	Integrase core domain; Region: rve; cl01316
449447006932	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
449447006933	FMN binding site [chemical binding]; other site
449447006934	active site
449447006935	substrate binding site [chemical binding]; other site
449447006936	catalytic residue [active]
449447006937	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447006938	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
449447006939	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
449447006940	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447006941	FeS/SAM binding site; other site
449447006942	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
449447006943	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447006944	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447006945	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
449447006946	putative ADP-binding pocket [chemical binding]; other site
449447006947	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
449447006948	binding surface
449447006949	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
449447006950	protein binding surface [polypeptide binding]; other site
449447006951	L-aspartate oxidase; Provisional; Region: PRK07395
449447006952	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447006953	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
449447006954	photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515
449447006955	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
449447006956	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
449447006957	dimer interface [polypeptide binding]; other site
449447006958	decamer (pentamer of dimers) interface [polypeptide binding]; other site
449447006959	catalytic triad [active]
449447006960	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447006961	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447006962	Probable transposase; Region: OrfB_IS605; pfam01385
449447006963	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447006964	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
449447006965	catalytic loop [active]
449447006966	iron binding site [ion binding]; other site
449447006967	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
449447006968	Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074
449447006969	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
449447006970	Photosystem II reaction centre N protein (psbN); Region: PsbN; cl03605
449447006971	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
449447006972	active site clefts [active]
449447006973	zinc binding site [ion binding]; other site
449447006974	dimer interface [polypeptide binding]; other site
449447006975	Photosystem II reaction centre N protein (psbN); Region: PsbN; cl03605
449447006976	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
449447006977	active site clefts [active]
449447006978	zinc binding site [ion binding]; other site
449447006979	dimer interface [polypeptide binding]; other site
449447006980	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
449447006981	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
449447006982	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
449447006983	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
449447006984	putative homodimer interface [polypeptide binding]; other site
449447006985	KOW motif; Region: KOW; cl00354
449447006986	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
449447006987	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
449447006988	23S rRNA interface [nucleotide binding]; other site
449447006989	L7/L12 interface [polypeptide binding]; other site
449447006990	putative thiostrepton binding site; other site
449447006991	L25 interface [polypeptide binding]; other site
449447006992	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
449447006993	mRNA/rRNA interface [nucleotide binding]; other site
449447006994	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447006995	Protein of unknown function (DUF497); Region: DUF497; cl01108
449447006996	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
449447006997	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
449447006998	active site
449447006999	Riboflavin kinase; Region: Flavokinase; cl03312
449447007000	MoxR-like ATPases [General function prediction only]; Region: COG0714
449447007001	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447007002	Walker A motif; other site
449447007003	ATP binding site [chemical binding]; other site
449447007004	Walker B motif; other site
449447007005	arginine finger; other site
449447007006	Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335
449447007007	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
449447007008	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
449447007009	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
449447007010	active site
449447007011	metal binding site [ion binding]; metal-binding site
449447007012	O-Antigen ligase; Region: Wzy_C; cl04850
449447007013	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
449447007014	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
449447007015	dimer interface [polypeptide binding]; other site
449447007016	PYR/PP interface [polypeptide binding]; other site
449447007017	TPP binding site [chemical binding]; other site
449447007018	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
449447007019	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
449447007020	TPP-binding site [chemical binding]; other site
449447007021	dimer interface [polypeptide binding]; other site
449447007022	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
449447007023	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447007024	Walker A/P-loop; other site
449447007025	ATP binding site [chemical binding]; other site
449447007026	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447007027	ABC transporter signature motif; other site
449447007028	Walker B; other site
449447007029	D-loop; other site
449447007030	H-loop/switch region; other site
449447007031	Domain of unknown function (DUF1832); Region: DUF1832; cl07463
449447007032	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243
449447007033	Cupin domain; Region: Cupin_2; cl09118
449447007034	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447007035	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447007036	S-adenosylmethionine binding site [chemical binding]; other site
449447007037	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
449447007038	active site
449447007039	iron coordination sites [ion binding]; other site
449447007040	substrate binding pocket [chemical binding]; other site
449447007041	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
449447007042	NADPH bind site [chemical binding]; other site
449447007043	putative FMN binding site [chemical binding]; other site
449447007044	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
449447007045	putative FMN binding site [chemical binding]; other site
449447007046	NADPH bind site [chemical binding]; other site
449447007047	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
449447007048	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447007049	putative active site [active]
449447007050	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
449447007051	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
449447007052	Cupin domain; Region: Cupin_2; cl09118
449447007053	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
449447007054	homotrimer interface [polypeptide binding]; other site
449447007055	Walker A motif; other site
449447007056	GTP binding site [chemical binding]; other site
449447007057	Walker B motif; other site
449447007058	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447007059	S-adenosylmethionine binding site [chemical binding]; other site
449447007060	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
449447007061	substrate binding site [chemical binding]; other site
449447007062	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
449447007063	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447007064	Walker A/P-loop; other site
449447007065	ATP binding site [chemical binding]; other site
449447007066	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
449447007067	Fusaric acid resistance protein-like; Region: FUSC_2; cl15844
449447007068	Bacterial Ig-like domain; Region: Big_5; cl01012
449447007069	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
449447007070	Low molecular weight phosphatase family; Region: LMWPc; cl00105
449447007071	PemK-like protein; Region: PemK; cl00995
449447007072	Fe-S metabolism associated domain; Region: SufE; cl00951
449447007073	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
449447007074	metal binding site 2 [ion binding]; metal-binding site
449447007075	putative DNA binding helix; other site
449447007076	metal binding site 1 [ion binding]; metal-binding site
449447007077	dimer interface [polypeptide binding]; other site
449447007078	structural Zn2+ binding site [ion binding]; other site
449447007079	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
449447007080	HSP70 interaction site [polypeptide binding]; other site
449447007081	TPR repeat; Region: TPR_11; pfam13414
449447007082	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447007083	binding surface
449447007084	TPR motif; other site
449447007085	TPR repeat; Region: TPR_11; pfam13414
449447007086	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
449447007087	binding surface
449447007088	TPR motif; other site
449447007089	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
449447007090	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
449447007091	inhibitor-cofactor binding pocket; inhibition site
449447007092	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447007093	catalytic residue [active]
449447007094	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
449447007095	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
449447007096	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
449447007097	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
449447007098	SLBB domain; Region: SLBB; pfam10531
449447007099	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
449447007100	tyrosine kinase; Provisional; Region: PRK11519
449447007101	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
449447007102	Nucleotide binding site [chemical binding]; other site
449447007103	DTAP/Switch II; other site
449447007104	Uncharacterized BCR, COG1649; Region: DUF187; cl15398
449447007105	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922
449447007106	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
449447007107	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
449447007108	P loop; other site
449447007109	Nucleotide binding site [chemical binding]; other site
449447007110	DTAP/Switch II; other site
449447007111	Switch I; other site
449447007112	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
449447007113	This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins.  sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298
449447007114	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
449447007115	tetramerization interface [polypeptide binding]; other site
449447007116	active site
449447007117	Domain of unknown function (DUF3598); Region: DUF3598; pfam12204
449447007118	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
449447007119	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
449447007120	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
449447007121	dimer interface [polypeptide binding]; other site
449447007122	anticodon binding site; other site
449447007123	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
449447007124	homodimer interface [polypeptide binding]; other site
449447007125	motif 1; other site
449447007126	active site
449447007127	motif 2; other site
449447007128	GAD domain; Region: GAD; pfam02938
449447007129	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
449447007130	active site
449447007131	motif 3; other site
449447007132	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
449447007133	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
449447007134	TIR domain; Region: TIR_2; cl15770
449447007135	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
449447007136	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
449447007137	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
449447007138	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
449447007139	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
449447007140	active site
449447007141	catalytic tetrad [active]
449447007142	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
449447007143	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
449447007144	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
449447007145	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
449447007146	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
449447007147	RNA binding surface [nucleotide binding]; other site
449447007148	Pseudouridine synthases  are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870
449447007149	active site
449447007150	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
449447007151	homotetrameric interface [polypeptide binding]; other site
449447007152	putative active site [active]
449447007153	metal binding site [ion binding]; metal-binding site
449447007154	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447007155	structural tetrad; other site
449447007156	FOG: WD40 repeat [General function prediction only]; Region: COG2319
449447007157	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447007158	structural tetrad; other site
449447007159	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
449447007160	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
449447007161	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
449447007162	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
449447007163	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
449447007164	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
449447007165	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447007166	active site
449447007167	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
449447007168	phosphorylation site [posttranslational modification]
449447007169	intermolecular recognition site; other site
449447007170	dimerization interface [polypeptide binding]; other site
449447007171	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447007172	dimer interface [polypeptide binding]; other site
449447007173	phosphorylation site [posttranslational modification]
449447007174	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447007175	ATP binding site [chemical binding]; other site
449447007176	Mg2+ binding site [ion binding]; other site
449447007177	G-X-G motif; other site
449447007178	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
449447007179	O-Antigen ligase; Region: Wzy_C; cl04850
449447007180	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
449447007181	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
449447007182	metal binding site [ion binding]; metal-binding site
449447007183	DNA polymerase III subunit alpha; Reviewed; Region: PRK07373
449447007184	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780
449447007185	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
449447007186	generic binding surface I; other site
449447007187	generic binding surface II; other site
449447007188	Gas vesicle protein; Region: Gas_vesicle; cl02954
449447007189	Gas vesicle protein; Region: Gas_vesicle; cl02954
449447007190	Gas vesicle protein; Region: Gas_vesicle; cl02954
449447007191	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
449447007192	type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448
449447007193	gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640
449447007194	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447007195	Walker A motif; other site
449447007196	ATP binding site [chemical binding]; other site
449447007197	Walker B motif; other site
449447007198	arginine finger; other site
449447007199	Gas vesicle protein; Region: Gas_vesicle; cl02954
449447007200	Gas vesicle protein K; Region: GvpK; pfam05121
449447007201	Gas vesicle protein; Region: Gas_vesicle; cl02954
449447007202	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
449447007203	Gas vesicle protein G; Region: GvpG; pfam05120
449447007204	Protein of unknown function (DUF342); Region: DUF342; pfam03961
449447007205	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
449447007206	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
449447007207	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
449447007208	P loop; other site
449447007209	Nucleotide binding site [chemical binding]; other site
449447007210	DTAP/Switch II; other site
449447007211	Switch I; other site
449447007212	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
449447007213	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
449447007214	DTAP/Switch II; other site
449447007215	Switch I; other site
449447007216	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447007217	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
449447007218	Walker A motif; other site
449447007219	ATP binding site [chemical binding]; other site
449447007220	Walker B motif; other site
449447007221	arginine finger; other site
449447007222	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447007223	Walker A motif; other site
449447007224	ATP binding site [chemical binding]; other site
449447007225	Walker B motif; other site
449447007226	arginine finger; other site
449447007227	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
449447007228	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
449447007229	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
449447007230	Glutaminase; Region: Glutaminase; cl00907
449447007231	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
449447007232	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
449447007233	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
449447007234	shikimate binding site; other site
449447007235	NAD(P) binding site [chemical binding]; other site
449447007236	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
449447007237	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
449447007238	EamA-like transporter family; Region: EamA; cl01037
449447007239	EamA-like transporter family; Region: EamA; cl01037
449447007240	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447007241	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
449447007242	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
449447007243	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
449447007244	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447007245	S-adenosylmethionine binding site [chemical binding]; other site
449447007246	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
449447007247	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
449447007248	Repair protein; Region: Repair_PSII; cl01535
449447007249	YtxH-like protein; Region: YtxH; cl02079
449447007250	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447007251	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447007252	Probable transposase; Region: OrfB_IS605; pfam01385
449447007253	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447007254	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447007255	Transposase [DNA replication, recombination, and repair]; Region: COG5433
449447007256	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447007257	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447007258	dimer interface [polypeptide binding]; other site
449447007259	conserved gate region; other site
449447007260	putative PBP binding loops; other site
449447007261	ABC-ATPase subunit interface; other site
449447007262	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
449447007263	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
449447007264	dimer interface [polypeptide binding]; other site
449447007265	ssDNA binding site [nucleotide binding]; other site
449447007266	tetramer (dimer of dimers) interface [polypeptide binding]; other site
449447007267	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447007268	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
449447007269	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447007270	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447007271	Probable transposase; Region: OrfB_IS605; pfam01385
449447007272	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447007273	Protein of unknown function (DUF3038); Region: DUF3038; pfam11237
449447007274	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
449447007275	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447007276	Probable transposase; Region: OrfB_IS605; pfam01385
449447007277	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447007278	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447007279	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
449447007280	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447007281	Probable transposase; Region: OrfB_IS605; pfam01385
449447007282	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447007283	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
449447007284	Tryptophan-rich protein (DUF2389); Region: DUF2389; cl09726
449447007285	SOS regulatory protein LexA; Region: lexA; TIGR00498
449447007286	Helix-turn-helix domains; Region: HTH; cl00088
449447007287	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
449447007288	Catalytic site [active]
449447007289	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
449447007290	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
449447007291	dimer interface [polypeptide binding]; other site
449447007292	PYR/PP interface [polypeptide binding]; other site
449447007293	TPP binding site [chemical binding]; other site
449447007294	substrate binding site [chemical binding]; other site
449447007295	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
449447007296	Domain of unknown function; Region: EKR; cl11037
449447007297	4Fe-4S binding domain; Region: Fer4; cl02805
449447007298	4Fe-4S binding domain; Region: Fer4; cl02805
449447007299	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
449447007300	TPP-binding site [chemical binding]; other site
449447007301	dimer interface [polypeptide binding]; other site
449447007302	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
449447007303	Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739
449447007304	putative active site [active]
449447007305	putative FMN binding site [chemical binding]; other site
449447007306	putative substrate binding site [chemical binding]; other site
449447007307	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
449447007308	active site
449447007309	ADP/pyrophosphate binding site [chemical binding]; other site
449447007310	dimerization interface [polypeptide binding]; other site
449447007311	allosteric effector site; other site
449447007312	fructose-1,6-bisphosphate binding site; other site
449447007313	YcfA-like protein; Region: YcfA; cl00752
449447007314	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
449447007315	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447007316	structural tetrad; other site
449447007317	PQQ-like domain; Region: PQQ_2; pfam13360
449447007318	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
449447007319	Axonemal dynein light chain; Region: Ax_dynein_light; pfam10211
449447007320	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447007321	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
449447007322	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
449447007323	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
449447007324	amidohydrolase; Region: amidohydrolases; TIGR01891
449447007325	metal binding site [ion binding]; metal-binding site
449447007326	dimer interface [polypeptide binding]; other site
449447007327	MEKHLA domain; Region: MEKHLA; pfam08670
449447007328	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
449447007329	active site
449447007330	dimer interface [polypeptide binding]; other site
449447007331	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
449447007332	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447007333	S-adenosylmethionine binding site [chemical binding]; other site
449447007334	Tic22-like family; Region: Tic22; cl04468
449447007335	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
449447007336	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
449447007337	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447007338	Helix-turn-helix domains; Region: HTH; cl00088
449447007339	Integrase core domain; Region: rve; cl01316
449447007340	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447007341	Transposase domain (DUF772); Region: DUF772; cl15789
449447007342	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
449447007343	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447007344	active site
449447007345	phosphorylation site [posttranslational modification]
449447007346	intermolecular recognition site; other site
449447007347	dimerization interface [polypeptide binding]; other site
449447007348	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
449447007349	DNA binding residues [nucleotide binding]
449447007350	dimerization interface [polypeptide binding]; other site
449447007351	phosphoribulokinase; Provisional; Region: PRK07429
449447007352	Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026
449447007353	active site
449447007354	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447007355	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447007356	Probable transposase; Region: OrfB_IS605; pfam01385
449447007357	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447007358	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
449447007359	phosphopeptide binding site; other site
449447007360	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
449447007361	metal binding site [ion binding]; metal-binding site
449447007362	active site
449447007363	I-site; other site
449447007364	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
449447007365	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
449447007366	Predicted kinase [General function prediction only]; Region: COG0645
449447007367	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
449447007368	ATP-binding site [chemical binding]; other site
449447007369	Gluconate-6-phosphate binding site [chemical binding]; other site
449447007370	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447007371	putative active site [active]
449447007372	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447007373	putative active site [active]
449447007374	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
449447007375	Condensation domain; Region: Condensation; pfam00668
449447007376	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
449447007377	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
449447007378	AMP-binding enzyme; Region: AMP-binding; cl15778
449447007379	AMP-binding enzyme; Region: AMP-binding; cl15778
449447007380	Phosphopantetheine attachment site; Region: PP-binding; cl09936
449447007381	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
449447007382	peptide synthase; Provisional; Region: PRK12316
449447007383	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
449447007384	AMP-binding enzyme; Region: AMP-binding; cl15778
449447007385	AMP-binding enzyme; Region: AMP-binding; cl15778
449447007386	Phosphopantetheine attachment site; Region: PP-binding; cl09936
449447007387	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
449447007388	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
449447007389	AMP-binding enzyme; Region: AMP-binding; cl15778
449447007390	acyl-CoA synthetase; Validated; Region: PRK08308
449447007391	Phosphopantetheine attachment site; Region: PP-binding; cl09936
449447007392	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
449447007393	AMP-binding enzyme; Region: AMP-binding; cl15778
449447007394	Methyltransferase domain; Region: Methyltransf_31; pfam13847
449447007395	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447007396	S-adenosylmethionine binding site [chemical binding]; other site
449447007397	Microcystin synthetase C terminal; Region: McyA_C; pfam12593
449447007398	peptide synthase; Provisional; Region: PRK12467
449447007399	Phosphopantetheine attachment site; Region: PP-binding; cl09936
449447007400	AMP-binding enzyme; Region: AMP-binding; cl15778
449447007401	Phosphopantetheine attachment site; Region: PP-binding; cl09936
449447007402	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
449447007403	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
449447007404	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
449447007405	active site
449447007406	Acyl transferase domain; Region: Acyl_transf_1; cl08282
449447007407	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
449447007408	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
449447007409	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447007410	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
449447007411	putative NADP binding site [chemical binding]; other site
449447007412	active site
449447007413	Phosphopantetheine attachment site; Region: PP-binding; cl09936
449447007414	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
449447007415	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
449447007416	active site
449447007417	Acyl transferase domain; Region: Acyl_transf_1; cl08282
449447007418	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
449447007419	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
449447007420	putative NADP binding site [chemical binding]; other site
449447007421	active site
449447007422	Phosphopantetheine attachment site; Region: PP-binding; cl09936
449447007423	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
449447007424	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
449447007425	active site
449447007426	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
449447007427	Acyl transferase domain; Region: Acyl_transf_1; cl08282
449447007428	Phosphopantetheine attachment site; Region: PP-binding; cl09936
449447007429	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447007430	S-adenosylmethionine binding site [chemical binding]; other site
449447007431	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
449447007432	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
449447007433	inhibitor-cofactor binding pocket; inhibition site
449447007434	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447007435	catalytic residue [active]
449447007436	peptide synthase; Provisional; Region: PRK12467
449447007437	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
449447007438	AMP-binding enzyme; Region: AMP-binding; cl15778
449447007439	Phosphopantetheine attachment site; Region: PP-binding; cl09936
449447007440	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
449447007441	aspartate racemase; Region: asp_race; TIGR00035
449447007442	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
449447007443	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
449447007444	AMP-binding enzyme; Region: AMP-binding; cl15778
449447007445	Phosphopantetheine attachment site; Region: PP-binding; cl09936
449447007446	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
449447007447	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
449447007448	active site
449447007449	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
449447007450	Acyl transferase domain; Region: Acyl_transf_1; cl08282
449447007451	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447007452	S-adenosylmethionine binding site [chemical binding]; other site
449447007453	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
449447007454	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
449447007455	putative NADP binding site [chemical binding]; other site
449447007456	active site
449447007457	Phosphopantetheine attachment site; Region: PP-binding; cl09936
449447007458	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
449447007459	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
449447007460	Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome.  The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223
449447007461	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
449447007462	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447007463	Methyltransferase domain; Region: Methyltransf_31; pfam13847
449447007464	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447007465	S-adenosylmethionine binding site [chemical binding]; other site
449447007466	DNA polymerase III subunit beta; Validated; Region: PRK05643
449447007467	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
449447007468	putative DNA binding surface [nucleotide binding]; other site
449447007469	dimer interface [polypeptide binding]; other site
449447007470	beta-clamp/clamp loader binding surface; other site
449447007471	beta-clamp/translesion DNA polymerase binding surface; other site
449447007472	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
449447007473	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
449447007474	inhibitor-cofactor binding pocket; inhibition site
449447007475	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447007476	catalytic residue [active]
449447007477	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
449447007478	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
449447007479	Voltage gated chloride channel; Region: Voltage_CLC; pfam00654
449447007480	Cl- selectivity filter; other site
449447007481	Cl- binding residues [ion binding]; other site
449447007482	pore gating glutamate residue; other site
449447007483	dimer interface [polypeptide binding]; other site
449447007484	H+/Cl- coupling transport residue; other site
449447007485	FOG: CBS domain [General function prediction only]; Region: COG0517
449447007486	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
449447007487	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
449447007488	Ligand Binding Site [chemical binding]; other site
449447007489	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
449447007490	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447007491	putative active site [active]
449447007492	large terminase protein; Provisional; Region: 17; PHA02533
449447007493	Haemolysin XhlA; Region: XhlA; pfam10779
449447007494	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
449447007495	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
449447007496	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
449447007497	Mg++ binding site [ion binding]; other site
449447007498	putative catalytic motif [active]
449447007499	substrate binding site [chemical binding]; other site
449447007500	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
449447007501	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
449447007502	dimer interface [polypeptide binding]; other site
449447007503	glycine-pyridoxal phosphate binding site [chemical binding]; other site
449447007504	active site
449447007505	folate binding site [chemical binding]; other site
449447007506	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
449447007507	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656
449447007508	Septum formation topological specificity factor MinE; Region: MinE; cl00538
449447007509	septum site-determining protein MinD; Region: minD_bact; TIGR01968
449447007510	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
449447007511	Switch I; other site
449447007512	Switch II; other site
449447007513	septum formation inhibitor; Reviewed; Region: minC; PRK00513
449447007514	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
449447007515	Haemolysin XhlA; Region: XhlA; pfam10779
449447007516	Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663
449447007517	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
449447007518	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
449447007519	Integrase core domain; Region: rve; cl01316
449447007520	Winged helix-turn helix; Region: HTH_29; pfam13551
449447007521	Helix-turn-helix domains; Region: HTH; cl00088
449447007522	Helix-turn-helix domains; Region: HTH; cl00088
449447007523	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447007524	Helix-turn-helix domains; Region: HTH; cl00088
449447007525	Integrase core domain; Region: rve; cl01316
449447007526	Protein of unknown function, DUF1537; Region: DUF1537; cl01345
449447007527	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
449447007528	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
449447007529	active site
449447007530	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
449447007531	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
449447007532	glycine dehydrogenase; Provisional; Region: PRK05367
449447007533	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
449447007534	tetramer interface [polypeptide binding]; other site
449447007535	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447007536	catalytic residue [active]
449447007537	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
449447007538	tetramer interface [polypeptide binding]; other site
449447007539	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447007540	catalytic residue [active]
449447007541	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
449447007542	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224
449447007543	homodimer interface [polypeptide binding]; other site
449447007544	substrate-cofactor binding pocket; other site
449447007545	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447007546	catalytic residue [active]
449447007547	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
449447007548	dimer interface [polypeptide binding]; other site
449447007549	ssDNA binding site [nucleotide binding]; other site
449447007550	tetramer (dimer of dimers) interface [polypeptide binding]; other site
449447007551	rod shape-determining protein MreB; Provisional; Region: PRK13927
449447007552	Cell division protein FtsA; Region: FtsA; cl11496
449447007553	rod shape-determining protein MreC; Region: MreC; pfam04085
449447007554	Transglycosylase; Region: Transgly; cl07896
449447007555	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
449447007556	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
449447007557	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
449447007558	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
449447007559	PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to...; Region: PDZ_glycyl_aminopeptidase; cd00990
449447007560	protein binding site [polypeptide binding]; other site
449447007561	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
449447007562	homodimer interface [polypeptide binding]; other site
449447007563	substrate-cofactor binding pocket; other site
449447007564	catalytic residue [active]
449447007565	circadian clock protein KaiC; Reviewed; Region: PRK09302
449447007566	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
449447007567	Walker A motif; other site
449447007568	ATP binding site [chemical binding]; other site
449447007569	Walker B motif; other site
449447007570	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447007571	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447007572	Walker A motif; other site
449447007573	ATP binding site [chemical binding]; other site
449447007574	Walker B motif; other site
449447007575	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
449447007576	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
449447007577	substrate binding pocket [chemical binding]; other site
449447007578	membrane-bound complex binding site; other site
449447007579	hinge residues; other site
449447007580	DNA polymerase III subunit alpha; Reviewed; Region: PRK09532
449447007581	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
449447007582	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
449447007583	thioester formation/cholesterol transfer; other site
449447007584	protein-splicing catalytic site; other site
449447007585	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
449447007586	putative binding surface; other site
449447007587	active site
449447007588	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447007589	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447007590	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
449447007591	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
449447007592	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
449447007593	Surface antigen; Region: Bac_surface_Ag; cl03097
449447007594	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
449447007595	UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512
449447007596	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
449447007597	diiron binding motif [ion binding]; other site
449447007598	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
449447007599	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
449447007600	Clp amino terminal domain; Region: Clp_N; pfam02861
449447007601	Clp amino terminal domain; Region: Clp_N; pfam02861
449447007602	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447007603	Walker A motif; other site
449447007604	ATP binding site [chemical binding]; other site
449447007605	Walker B motif; other site
449447007606	arginine finger; other site
449447007607	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447007608	Walker A motif; other site
449447007609	ATP binding site [chemical binding]; other site
449447007610	Walker B motif; other site
449447007611	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
449447007612	N-myristoyl transferase [Lipid metabolism]; Region: NMT1; COG5092
449447007613	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
449447007614	Coenzyme A binding pocket [chemical binding]; other site
449447007615	GLTT repeat (6 copies); Region: GLTT; pfam01744
449447007616	Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219
449447007617	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
449447007618	FAD binding site [chemical binding]; other site
449447007619	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835
449447007620	active site
449447007621	catalytic triad [active]
449447007622	oxyanion hole [active]
449447007623	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447007624	Transposase domain (DUF772); Region: DUF772; cl15789
449447007625	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447007626	Helix-turn-helix domains; Region: HTH; cl00088
449447007627	Helix-turn-helix domains; Region: HTH; cl00088
449447007628	Integrase core domain; Region: rve; cl01316
449447007629	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447007630	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447007631	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
449447007632	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447007633	Transposase [DNA replication, recombination, and repair]; Region: COG5433
449447007634	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
449447007635	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
449447007636	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
449447007637	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
449447007638	Winged helix-turn helix; Region: HTH_29; pfam13551
449447007639	Helix-turn-helix domains; Region: HTH; cl00088
449447007640	Winged helix-turn helix; Region: HTH_33; pfam13592
449447007641	Integrase core domain; Region: rve; cl01316
449447007642	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
449447007643	hypothetical protein; Provisional; Region: PRK06922
449447007644	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
449447007645	ATP binding site [chemical binding]; other site
449447007646	putative Mg++ binding site [ion binding]; other site
449447007647	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
449447007648	nucleotide binding region [chemical binding]; other site
449447007649	ATP-binding site [chemical binding]; other site
449447007650	Protein of unknown function (DUF3285); Region: DUF3285; pfam11688
449447007651	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
449447007652	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526
449447007653	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
449447007654	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447007655	S-adenosylmethionine binding site [chemical binding]; other site
449447007656	Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
449447007657	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447007658	Walker A/P-loop; other site
449447007659	ATP binding site [chemical binding]; other site
449447007660	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447007661	ABC transporter signature motif; other site
449447007662	Walker B; other site
449447007663	D-loop; other site
449447007664	H-loop/switch region; other site
449447007665	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
449447007666	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863
449447007667	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
449447007668	dimer interface [polypeptide binding]; other site
449447007669	active site
449447007670	Schiff base residues; other site
449447007671	golgi membrane calcium-translocating P-type ATPase; Region: ATPase-IIA2_Ca; TIGR01522
449447007672	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
449447007673	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
449447007674	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
449447007675	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
449447007676	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
449447007677	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
449447007678	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
449447007679	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
449447007680	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
449447007681	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447007682	Walker A/P-loop; other site
449447007683	ATP binding site [chemical binding]; other site
449447007684	Q-loop/lid; other site
449447007685	ABC transporter signature motif; other site
449447007686	Walker B; other site
449447007687	D-loop; other site
449447007688	H-loop/switch region; other site
449447007689	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447007690	Walker A/P-loop; other site
449447007691	ATP binding site [chemical binding]; other site
449447007692	AAA domain; Region: AAA_21; pfam13304
449447007693	GTP-binding protein LepA; Provisional; Region: PRK05433
449447007694	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
449447007695	G1 box; other site
449447007696	putative GEF interaction site [polypeptide binding]; other site
449447007697	GTP/Mg2+ binding site [chemical binding]; other site
449447007698	Switch I region; other site
449447007699	G2 box; other site
449447007700	G3 box; other site
449447007701	Switch II region; other site
449447007702	G4 box; other site
449447007703	G5 box; other site
449447007704	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
449447007705	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
449447007706	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
449447007707	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
449447007708	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447007709	S-adenosylmethionine binding site [chemical binding]; other site
449447007710	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
449447007711	CHAT domain; Region: CHAT; pfam12770
449447007712	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447007713	Transposase domain (DUF772); Region: DUF772; cl15789
449447007714	CHAT domain; Region: CHAT; pfam12770
449447007715	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447007716	GUN4-like; Region: GUN4; pfam05419
449447007717	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
449447007718	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
449447007719	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
449447007720	Dimer interface [polypeptide binding]; other site
449447007721	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
449447007722	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447007723	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
449447007724	aromatic arch; other site
449447007725	DCoH dimer interaction site [polypeptide binding]; other site
449447007726	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
449447007727	DCoH tetramer interaction site [polypeptide binding]; other site
449447007728	substrate binding site [chemical binding]; other site
449447007729	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
449447007730	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
449447007731	ATP binding site [chemical binding]; other site
449447007732	putative Mg++ binding site [ion binding]; other site
449447007733	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
449447007734	nucleotide binding region [chemical binding]; other site
449447007735	ATP-binding site [chemical binding]; other site
449447007736	heat shock protein 90; Provisional; Region: PRK05218
449447007737	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447007738	ATP binding site [chemical binding]; other site
449447007739	Mg2+ binding site [ion binding]; other site
449447007740	G-X-G motif; other site
449447007741	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
449447007742	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
449447007743	catalytic motif [active]
449447007744	Zn binding site [ion binding]; other site
449447007745	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
449447007746	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
449447007747	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
449447007748	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
449447007749	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
449447007750	Ligand binding site; other site
449447007751	Putative Catalytic site; other site
449447007752	DXD motif; other site
449447007753	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
449447007754	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
449447007755	Histone deacetylase domain; Region: Hist_deacetyl; cl02986
449447007756	Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035
449447007757	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
449447007758	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
449447007759	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
449447007760	YcfA-like protein; Region: YcfA; cl00752
449447007761	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
449447007762	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
449447007763	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
449447007764	oligomeric interface; other site
449447007765	putative active site [active]
449447007766	homodimer interface [polypeptide binding]; other site
449447007767	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
449447007768	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
449447007769	Amidinotransferase; Region: Amidinotransf; cl12043
449447007770	Uncharacterized conserved protein [Function unknown]; Region: COG1915
449447007771	LOR/SDH bifunctional enzyme conserved region; Region: Saccharop_dh_N; pfam04455
449447007772	Uncharacterized conserved protein [Function unknown]; Region: COG4715
449447007773	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447007774	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447007775	Uncharacterized conserved protein [Function unknown]; Region: COG4715
449447007776	SWIM zinc finger; Region: SWIM; cl15408
449447007777	ParB-like nuclease domain; Region: ParBc; cl02129
449447007778	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
449447007779	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
449447007780	dimer interface [polypeptide binding]; other site
449447007781	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
449447007782	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447007783	M28 Zn-Peptidases; Region: M28_like_1; cd05640
449447007784	metal binding site [ion binding]; metal-binding site
449447007785	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
449447007786	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447007787	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
449447007788	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
449447007789	active site
449447007790	Substrate binding site; other site
449447007791	Mg++ binding site; other site
449447007792	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
449447007793	putative trimer interface [polypeptide binding]; other site
449447007794	putative CoA binding site [chemical binding]; other site
449447007795	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
449447007796	GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity.  The protein contains an...; Region: MPG1_transferase; cd05805
449447007797	Integrase core domain; Region: rve; cl01316
449447007798	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
449447007799	Helix-turn-helix domains; Region: HTH; cl00088
449447007800	Helix-turn-helix domains; Region: HTH; cl00088
449447007801	Integrase core domain; Region: rve; cl01316
449447007802	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044
449447007803	RDD family; Region: RDD; cl00746
449447007804	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447007805	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447007806	Probable transposase; Region: OrfB_IS605; pfam01385
449447007807	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447007808	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
449447007809	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
449447007810	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
449447007811	catalytic residue [active]
449447007812	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447007813	putative active site [active]
449447007814	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
449447007815	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
449447007816	Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136
449447007817	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447007818	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
449447007819	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
449447007820	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
449447007821	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
449447007822	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687
449447007823	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
449447007824	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
449447007825	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
449447007826	Protein of unknown function (DUF3038); Region: DUF3038; pfam11237
449447007827	Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503
449447007828	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
449447007829	active site
449447007830	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
449447007831	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447007832	dimer interface [polypeptide binding]; other site
449447007833	conserved gate region; other site
449447007834	putative PBP binding loops; other site
449447007835	ABC-ATPase subunit interface; other site
449447007836	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
449447007837	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
449447007838	NADP binding site [chemical binding]; other site
449447007839	active site
449447007840	putative substrate binding site [chemical binding]; other site
449447007841	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
449447007842	Protein of unknown function (DUF4101); Region: DUF4101; pfam13355
449447007843	VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436
449447007844	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
449447007845	metal ion-dependent adhesion site (MIDAS); other site
449447007846	Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009
449447007847	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447007848	Walker A motif; other site
449447007849	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
449447007850	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
449447007851	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
449447007852	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447007853	active site
449447007854	ATP binding site [chemical binding]; other site
449447007855	substrate binding site [chemical binding]; other site
449447007856	activation loop (A-loop); other site
449447007857	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447007858	TPR repeat; Region: TPR_11; pfam13414
449447007859	binding surface
449447007860	TPR motif; other site
449447007861	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447007862	TPR motif; other site
449447007863	binding surface
449447007864	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
449447007865	binding surface
449447007866	TPR motif; other site
449447007867	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447007868	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447007869	binding surface
449447007870	TPR motif; other site
449447007871	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
449447007872	Protein phosphatase 2C; Region: PP2C; pfam00481
449447007873	active site
449447007874	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
449447007875	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
449447007876	phosphopeptide binding site; other site
449447007877	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
449447007878	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
449447007879	metal ion-dependent adhesion site (MIDAS); other site
449447007880	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
449447007881	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
449447007882	metal ion-dependent adhesion site (MIDAS); other site
449447007883	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
449447007884	metal ion-dependent adhesion site (MIDAS); other site
449447007885	GTPase RsgA; Reviewed; Region: PRK01889
449447007886	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447007887	Dynamin family; Region: Dynamin_N; pfam00350
449447007888	G1 box; other site
449447007889	GTP/Mg2+ binding site [chemical binding]; other site
449447007890	G2 box; other site
449447007891	Switch I region; other site
449447007892	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447007893	G3 box; other site
449447007894	Switch II region; other site
449447007895	GTP/Mg2+ binding site [chemical binding]; other site
449447007896	G4 box; other site
449447007897	G5 box; other site
449447007898	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
449447007899	Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250
449447007900	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
449447007901	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
449447007902	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
449447007903	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
449447007904	GUN4-like; Region: GUN4; pfam05419
449447007905	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
449447007906	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
449447007907	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447007908	Peptidase propeptide and YPEB domain; Region: PepSY; cl15815
449447007909	Surface antigen; Region: Bac_surface_Ag; cl03097
449447007910	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
449447007911	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
449447007912	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
449447007913	phosphorylation site [posttranslational modification]
449447007914	intermolecular recognition site; other site
449447007915	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
449447007916	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
449447007917	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
449447007918	CHASE2 domain; Region: CHASE2; cl01732
449447007919	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
449447007920	Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757
449447007921	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
449447007922	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447007923	putative active site [active]
449447007924	haemagglutination activity domain; Region: Haemagg_act; cl05436
449447007925	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
449447007926	binding surface
449447007927	TPR motif; other site
449447007928	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447007929	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447007930	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447007931	CHAT domain; Region: CHAT; pfam12770
449447007932	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
449447007933	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
449447007934	dimer interface [polypeptide binding]; other site
449447007935	catalytic residues [active]
449447007936	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
449447007937	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
449447007938	IHF dimer interface [polypeptide binding]; other site
449447007939	IHF - DNA interface [nucleotide binding]; other site
449447007940	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
449447007941	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
449447007942	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447007943	homodimer interface [polypeptide binding]; other site
449447007944	catalytic residue [active]
449447007945	Photosystem II protein; Region: PSII; cl08223
449447007946	photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153
449447007947	D2 subunit  of photosystem II (PS II); Region: Photosystem-II_D2; cd09288
449447007948	D1 interface; other site
449447007949	chlorophyll binding site; other site
449447007950	pheophytin binding site; other site
449447007951	beta carotene binding site; other site
449447007952	cytochrome b559 beta interface; other site
449447007953	quinone binding site; other site
449447007954	cytochrome b559 alpha interface; other site
449447007955	protein J interface; other site
449447007956	protein H interface; other site
449447007957	protein X interface; other site
449447007958	core light harvesting protein interface; other site
449447007959	protein L interface; other site
449447007960	CP43 interface; other site
449447007961	protein T interface; other site
449447007962	Fe binding site [ion binding]; other site
449447007963	protein M interface; other site
449447007964	Mn-stabilizing polypeptide interface; other site
449447007965	bromide binding site; other site
449447007966	cytochrome c-550 interface; other site
449447007967	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
449447007968	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
449447007969	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
449447007970	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
449447007971	HSP70 interaction site [polypeptide binding]; other site
449447007972	type III secretion system needle length determinant; Region: type_III_yscP; TIGR02514
449447007973	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447007974	TPR repeat; Region: TPR_11; pfam13414
449447007975	binding surface
449447007976	TPR motif; other site
449447007977	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
449447007978	active site
449447007979	dimerization interface [polypeptide binding]; other site
449447007980	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
449447007981	catalytic loop [active]
449447007982	iron binding site [ion binding]; other site
449447007983	UbiA prenyltransferase family; Region: UbiA; cl00337
449447007984	O-methyltransferase; Region: Methyltransf_3; pfam01596
449447007985	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447007986	S-adenosylmethionine binding site [chemical binding]; other site
449447007987	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
449447007988	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447007989	ATP binding site [chemical binding]; other site
449447007990	Mg2+ binding site [ion binding]; other site
449447007991	G-X-G motif; other site
449447007992	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
449447007993	Response regulator receiver domain; Region: Response_reg; pfam00072
449447007994	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447007995	active site
449447007996	phosphorylation site [posttranslational modification]
449447007997	intermolecular recognition site; other site
449447007998	dimerization interface [polypeptide binding]; other site
449447007999	Response regulator receiver domain; Region: Response_reg; pfam00072
449447008000	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447008001	active site
449447008002	phosphorylation site [posttranslational modification]
449447008003	intermolecular recognition site; other site
449447008004	dimerization interface [polypeptide binding]; other site
449447008005	Predicted RNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG2263
449447008006	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447008007	S-adenosylmethionine binding site [chemical binding]; other site
449447008008	excinuclease ABC subunit B; Provisional; Region: PRK05298
449447008009	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
449447008010	ATP binding site [chemical binding]; other site
449447008011	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
449447008012	nucleotide binding region [chemical binding]; other site
449447008013	ATP-binding site [chemical binding]; other site
449447008014	Ultra-violet resistance protein B; Region: UvrB; pfam12344
449447008015	UvrB/uvrC motif; Region: UVR; pfam02151
449447008016	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
449447008017	Uncharacterized BCR, COG1649; Region: DUF187; cl15398
449447008018	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
449447008019	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447008020	dimer interface [polypeptide binding]; other site
449447008021	conserved gate region; other site
449447008022	putative PBP binding loops; other site
449447008023	ABC-ATPase subunit interface; other site
449447008024	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
449447008025	Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957
449447008026	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
449447008027	TPP-binding site [chemical binding]; other site
449447008028	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
449447008029	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
449447008030	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
449447008031	polysaccharide export protein Wza; Provisional; Region: PRK15078
449447008032	SLBB domain; Region: SLBB; pfam10531
449447008033	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
449447008034	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
449447008035	active site
449447008036	catalytic tetrad [active]
449447008037	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
449447008038	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
449447008039	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
449447008040	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
449447008041	Chain length determinant protein; Region: Wzz; cl15801
449447008042	Chain length determinant protein; Region: Wzz; cl15801
449447008043	exopolysaccharide/PEPCTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
449447008044	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447008045	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
449447008046	active site
449447008047	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
449447008048	MatE; Region: MatE; cl10513
449447008049	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
449447008050	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
449447008051	active site
449447008052	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
449447008053	O-Antigen ligase; Region: Wzy_C; cl04850
449447008054	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447008055	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
449447008056	putative ADP-binding pocket [chemical binding]; other site
449447008057	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
449447008058	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
449447008059	trimer interface [polypeptide binding]; other site
449447008060	active site
449447008061	substrate binding site [chemical binding]; other site
449447008062	CoA binding site [chemical binding]; other site
449447008063	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
449447008064	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
449447008065	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
449447008066	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447008067	Walker A/P-loop; other site
449447008068	ATP binding site [chemical binding]; other site
449447008069	Q-loop/lid; other site
449447008070	ABC transporter signature motif; other site
449447008071	Walker B; other site
449447008072	D-loop; other site
449447008073	H-loop/switch region; other site
449447008074	ABC transporter; Region: ABC_tran_2; pfam12848
449447008075	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
449447008076	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
449447008077	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
449447008078	Cl- selectivity filter; other site
449447008079	Cl- binding residues [ion binding]; other site
449447008080	pore gating glutamate residue; other site
449447008081	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447008082	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447008083	Probable transposase; Region: OrfB_IS605; pfam01385
449447008084	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
449447008085	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
449447008086	dimer interface [polypeptide binding]; other site
449447008087	motif 1; other site
449447008088	active site
449447008089	motif 2; other site
449447008090	motif 3; other site
449447008091	Helix-turn-helix domains; Region: HTH; cl00088
449447008092	Winged helix-turn helix; Region: HTH_29; pfam13551
449447008093	Winged helix-turn helix; Region: HTH_33; pfam13592
449447008094	Integrase core domain; Region: rve; cl01316
449447008095	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447008096	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
449447008097	Calx-beta domain; Region: Calx-beta; cl02522
449447008098	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
449447008099	Dihaem cytochrome c; Region: DHC; pfam09626
449447008100	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
449447008101	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
449447008102	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
449447008103	MPT binding site; other site
449447008104	trimer interface [polypeptide binding]; other site
449447008105	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
449447008106	UreF; Region: UreF; pfam01730
449447008107	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
449447008108	putative metal binding site; other site
449447008109	putative acyl transferase; Provisional; Region: PRK10502
449447008110	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
449447008111	putative trimer interface [polypeptide binding]; other site
449447008112	putative active site [active]
449447008113	putative substrate binding site [chemical binding]; other site
449447008114	putative CoA binding site [chemical binding]; other site
449447008115	Mechanosensitive ion channel; Region: MS_channel; pfam00924
449447008116	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
449447008117	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447008118	Probable transposase; Region: OrfB_IS605; pfam01385
449447008119	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447008120	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
449447008121	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
449447008122	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
449447008123	Probable Catalytic site; other site
449447008124	metal-binding site
449447008125	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
449447008126	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
449447008127	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447008128	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
449447008129	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
449447008130	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
449447008131	Ligand binding site; other site
449447008132	Putative Catalytic site; other site
449447008133	DXD motif; other site
449447008134	GtrA-like protein; Region: GtrA; cl00971
449447008135	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447008136	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447008137	Probable transposase; Region: OrfB_IS605; pfam01385
449447008138	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447008139	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
449447008140	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
449447008141	Ligand binding site; other site
449447008142	Putative Catalytic site; other site
449447008143	DXD motif; other site
449447008144	Domain of unknown function (DUF1815); Region: DUF1815; pfam08844
449447008145	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447008146	Probable transposase; Region: OrfB_IS605; pfam01385
449447008147	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447008148	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447008149	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
449447008150	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
449447008151	DNA binding residues [nucleotide binding]
449447008152	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
449447008153	catalytic residues [active]
449447008154	catalytic nucleophile [active]
449447008155	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
449447008156	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
449447008157	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
449447008158	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
449447008159	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447008160	putative active site [active]
449447008161	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447008162	Protein of unknown function (DUF433); Region: DUF433; cl01030
449447008163	Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136
449447008164	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
449447008165	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011
449447008166	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
449447008167	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
449447008168	Walker A/P-loop; other site
449447008169	ATP binding site [chemical binding]; other site
449447008170	Q-loop/lid; other site
449447008171	ABC transporter signature motif; other site
449447008172	Walker B; other site
449447008173	D-loop; other site
449447008174	H-loop/switch region; other site
449447008175	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561
449447008176	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
449447008177	anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748
449447008178	TRAP binding interface [polypeptide binding]; other site
449447008179	Zn binding site [ion binding]; other site
449447008180	CpcD/allophycocyanin linker domain; Region: CpcD; cl03191
449447008181	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
449447008182	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
449447008183	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
449447008184	dimerization interface [polypeptide binding]; other site
449447008185	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447008186	dimer interface [polypeptide binding]; other site
449447008187	phosphorylation site [posttranslational modification]
449447008188	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447008189	ATP binding site [chemical binding]; other site
449447008190	Mg2+ binding site [ion binding]; other site
449447008191	G-X-G motif; other site
449447008192	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
449447008193	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447008194	ATP binding site [chemical binding]; other site
449447008195	Mg2+ binding site [ion binding]; other site
449447008196	G-X-G motif; other site
449447008197	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
449447008198	ATP binding site [chemical binding]; other site
449447008199	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
449447008200	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447008201	Probable transposase; Region: OrfB_IS605; pfam01385
449447008202	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447008203	Protein of unknown function (DUF3177); Region: DUF3177; pfam11375
449447008204	probable methyltransferase; Region: TIGR03438
449447008205	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
449447008206	TIGR03440 family protein; Region: unchr_TIGR03440
449447008207	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
449447008208	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
449447008209	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357
449447008210	putative metal binding site [ion binding]; other site
449447008211	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
449447008212	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
449447008213	active site
449447008214	catalytic triad [active]
449447008215	Response regulator receiver domain; Region: Response_reg; pfam00072
449447008216	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447008217	active site
449447008218	phosphorylation site [posttranslational modification]
449447008219	intermolecular recognition site; other site
449447008220	dimerization interface [polypeptide binding]; other site
449447008221	Protein of unknown function (DUF1350); Region: DUF1350; pfam07082
449447008222	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447008223	putative active site [active]
449447008224	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398
449447008225	FIST N domain; Region: FIST; cl10701
449447008226	FIST C domain; Region: FIST_C; pfam10442
449447008227	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447008228	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447008229	Probable transposase; Region: OrfB_IS605; pfam01385
449447008230	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447008231	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447008232	Probable transposase; Region: OrfB_IS605; pfam01385
449447008233	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447008234	PQ loop repeat; Region: PQ-loop; cl12056
449447008235	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
449447008236	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447008237	Probable transposase; Region: OrfB_IS605; pfam01385
449447008238	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447008239	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447008240	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447008241	Probable transposase; Region: OrfB_IS605; pfam01385
449447008242	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447008243	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
449447008244	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447008245	Walker A/P-loop; other site
449447008246	ATP binding site [chemical binding]; other site
449447008247	Q-loop/lid; other site
449447008248	ABC transporter signature motif; other site
449447008249	Walker B; other site
449447008250	D-loop; other site
449447008251	H-loop/switch region; other site
449447008252	ABC-2 type transporter; Region: ABC2_membrane; cl11417
449447008253	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
449447008254	ABC_KpsT_Wzt   The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export.  Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220
449447008255	Walker A/P-loop; other site
449447008256	ATP binding site [chemical binding]; other site
449447008257	Q-loop/lid; other site
449447008258	ABC transporter signature motif; other site
449447008259	Walker B; other site
449447008260	D-loop; other site
449447008261	H-loop/switch region; other site
449447008262	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
449447008263	Tetrahydromethanopterin S-methyltransferase, subunit A; Region: MtrA; cl04449
449447008264	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
449447008265	dimerization interface [polypeptide binding]; other site
449447008266	active site
449447008267	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
449447008268	thymidylate kinase; Region: DTMP_kinase; TIGR00041
449447008269	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
449447008270	TMP-binding site; other site
449447008271	ATP-binding site [chemical binding]; other site
449447008272	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
449447008273	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
449447008274	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
449447008275	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
449447008276	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
449447008277	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
449447008278	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
449447008279	putative metal binding site; other site
449447008280	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447008281	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447008282	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
449447008283	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
449447008284	DNA binding residues [nucleotide binding]
449447008285	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
449447008286	catalytic residues [active]
449447008287	catalytic nucleophile [active]
449447008288	thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615
449447008289	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
449447008290	thiamine phosphate binding site [chemical binding]; other site
449447008291	active site
449447008292	pyrophosphate binding site [ion binding]; other site
449447008293	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
449447008294	thiS-thiF/thiG interaction site; other site
449447008295	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447008296	Probable transposase; Region: OrfB_IS605; pfam01385
449447008297	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447008298	Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217
449447008299	AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911
449447008300	AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911
449447008301	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447008302	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447008303	Probable transposase; Region: OrfB_IS605; pfam01385
449447008304	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447008305	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
449447008306	catalytic loop [active]
449447008307	iron binding site [ion binding]; other site
449447008308	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
449447008309	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
449447008310	domain interfaces; other site
449447008311	active site
449447008312	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447008313	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447008314	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447008315	Transposase domain (DUF772); Region: DUF772; cl15789
449447008316	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
449447008317	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447008318	active site
449447008319	ATP binding site [chemical binding]; other site
449447008320	substrate binding site [chemical binding]; other site
449447008321	activation loop (A-loop); other site
449447008322	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
449447008323	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
449447008324	dimer interface [polypeptide binding]; other site
449447008325	motif 1; other site
449447008326	active site
449447008327	motif 2; other site
449447008328	motif 3; other site
449447008329	Lipoxygenase; Region: Lipoxygenase; pfam00305
449447008330	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
449447008331	elongation factor Tu; Region: tufA; CHL00071
449447008332	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
449447008333	G1 box; other site
449447008334	GEF interaction site [polypeptide binding]; other site
449447008335	GTP/Mg2+ binding site [chemical binding]; other site
449447008336	Switch I region; other site
449447008337	G2 box; other site
449447008338	G3 box; other site
449447008339	Switch II region; other site
449447008340	G4 box; other site
449447008341	G5 box; other site
449447008342	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
449447008343	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
449447008344	Antibiotic Binding Site [chemical binding]; other site
449447008345	elongation factor G; Reviewed; Region: PRK00007
449447008346	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
449447008347	G1 box; other site
449447008348	putative GEF interaction site [polypeptide binding]; other site
449447008349	GTP/Mg2+ binding site [chemical binding]; other site
449447008350	Switch I region; other site
449447008351	G2 box; other site
449447008352	G3 box; other site
449447008353	Switch II region; other site
449447008354	G4 box; other site
449447008355	G5 box; other site
449447008356	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
449447008357	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
449447008358	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
449447008359	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
449447008360	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
449447008361	S17 interaction site [polypeptide binding]; other site
449447008362	S8 interaction site; other site
449447008363	16S rRNA interaction site [nucleotide binding]; other site
449447008364	streptomycin interaction site [chemical binding]; other site
449447008365	23S rRNA interaction site [nucleotide binding]; other site
449447008366	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
449447008367	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
449447008368	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
449447008369	non-specific DNA binding site [nucleotide binding]; other site
449447008370	salt bridge; other site
449447008371	sequence-specific DNA binding site [nucleotide binding]; other site
449447008372	Domain of unknown function (DUF955); Region: DUF955; cl01076
449447008373	NurA domain; Region: NurA; cl09134
449447008374	Uncharacterized conserved protein [Function unknown]; Region: COG1432
449447008375	LabA_like proteins; Region: LabA; cd10911
449447008376	putative metal binding site [ion binding]; other site
449447008377	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
449447008378	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
449447008379	active site
449447008380	HIGH motif; other site
449447008381	KMSKS motif; other site
449447008382	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
449447008383	tRNA binding surface [nucleotide binding]; other site
449447008384	anticodon binding site; other site
449447008385	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
449447008386	putative acyl-acceptor binding pocket; other site
449447008387	Integrase core domain; Region: rve; cl01316
449447008388	Helix-turn-helix domains; Region: HTH; cl00088
449447008389	Winged helix-turn helix; Region: HTH_29; pfam13551
449447008390	Helix-turn-helix domains; Region: HTH; cl00088
449447008391	YcfA-like protein; Region: YcfA; cl00752
449447008392	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
449447008393	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
449447008394	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
449447008395	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
449447008396	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
449447008397	P-loop; other site
449447008398	Magnesium ion binding site [ion binding]; other site
449447008399	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
449447008400	Magnesium ion binding site [ion binding]; other site
449447008401	GAF domain; Region: GAF; cl15785
449447008402	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
449447008403	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
449447008404	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
449447008405	tetramer interface [polypeptide binding]; other site
449447008406	dimer interface [polypeptide binding]; other site
449447008407	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
449447008408	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447008409	active site
449447008410	phosphorylation site [posttranslational modification]
449447008411	intermolecular recognition site; other site
449447008412	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
449447008413	dimer interface [polypeptide binding]; other site
449447008414	[2Fe-2S] cluster binding site [ion binding]; other site
449447008415	Phospholipid methyltransferase; Region: PEMT; cl00763
449447008416	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
449447008417	catalytic residues [active]
449447008418	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
449447008419	metal ion-dependent adhesion site (MIDAS); other site
449447008420	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
449447008421	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
449447008422	active site
449447008423	NTP binding site [chemical binding]; other site
449447008424	metal binding triad [ion binding]; metal-binding site
449447008425	antibiotic binding site [chemical binding]; other site
449447008426	Protein of unknown function DUF86; Region: DUF86; cl01031
449447008427	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
449447008428	oligomeric interface; other site
449447008429	putative active site [active]
449447008430	homodimer interface [polypeptide binding]; other site
449447008431	Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248
449447008432	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
449447008433	active site
449447008434	ATP binding site [chemical binding]; other site
449447008435	substrate binding site [chemical binding]; other site
449447008436	activation loop (A-loop); other site
449447008437	Uncharacterized conserved protein [Function unknown]; Region: COG1262
449447008438	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
449447008439	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
449447008440	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447008441	Haemolysin XhlA; Region: XhlA; pfam10779
449447008442	Helix-turn-helix domains; Region: HTH; cl00088
449447008443	Winged helix-turn helix; Region: HTH_29; pfam13551
449447008444	Winged helix-turn helix; Region: HTH_33; pfam13592
449447008445	Integrase core domain; Region: rve; cl01316
449447008446	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
449447008447	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
449447008448	dimer interface [polypeptide binding]; other site
449447008449	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447008450	catalytic residue [active]
449447008451	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
449447008452	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
449447008453	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
449447008454	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
449447008455	Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085
449447008456	Uncharacterized conserved protein [Function unknown]; Region: COG1262
449447008457	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
449447008458	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447008459	Walker A motif; other site
449447008460	ATP binding site [chemical binding]; other site
449447008461	Walker B motif; other site
449447008462	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
449447008463	Fatty acid desaturase; Region: FA_desaturase; pfam00487
449447008464	putative di-iron ligands [ion binding]; other site
449447008465	Probable transposase; Region: OrfB_IS605; pfam01385
449447008466	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447008467	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447008468	Probable transposase; Region: OrfB_IS605; pfam01385
449447008469	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
449447008470	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
449447008471	catalytic residues [active]
449447008472	catalytic nucleophile [active]
449447008473	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
449447008474	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447008475	ribosomal protein L20; Region: rpl20; CHL00068
449447008476	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
449447008477	23S rRNA binding site [nucleotide binding]; other site
449447008478	L21 binding site [polypeptide binding]; other site
449447008479	L13 binding site [polypeptide binding]; other site
449447008480	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
449447008481	transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309
449447008482	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
449447008483	active site
449447008484	dimer interface [polypeptide binding]; other site
449447008485	catalytic residue [active]
449447008486	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
449447008487	Ca2+ binding site [ion binding]; other site
449447008488	Probable transposase; Region: OrfB_IS605; pfam01385
449447008489	ThiC family; Region: ThiC; cl08031
449447008490	CpeS-like protein; Region: CpeS; pfam09367
449447008491	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
449447008492	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
449447008493	putative radical transfer pathway; other site
449447008494	diiron center [ion binding]; other site
449447008495	dimer interface [polypeptide binding]; other site
449447008496	tyrosyl radical; other site
449447008497	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
449447008498	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447008499	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447008500	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447008501	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447008502	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447008503	ATP cone domain; Region: ATP-cone; pfam03477
449447008504	ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506
449447008505	Class I ribonucleotide reductase; Region: RNR_I; cd01679
449447008506	active site
449447008507	dimer interface [polypeptide binding]; other site
449447008508	catalytic residues [active]
449447008509	effector binding site; other site
449447008510	R2 peptide binding site; other site
449447008511	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
449447008512	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
449447008513	Helix-turn-helix domains; Region: HTH; cl00088
449447008514	Helix-turn-helix domains; Region: HTH; cl00088
449447008515	Integrase core domain; Region: rve; cl01316
449447008516	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
449447008517	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447008518	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
449447008519	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
449447008520	Coenzyme A binding pocket [chemical binding]; other site
449447008521	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
449447008522	Family of unknown function (DUF490); Region: DUF490; pfam04357
449447008523	Protein of unknown function (DUF3747); Region: DUF3747; pfam12565
449447008524	S-layer homology domain; Region: SLH; pfam00395
449447008525	S-layer homology domain; Region: SLH; pfam00395
449447008526	Transposase IS200 like; Region: Y1_Tnp; cl00848
449447008527	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447008528	Probable transposase; Region: OrfB_IS605; pfam01385
449447008529	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447008530	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
449447008531	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
449447008532	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
449447008533	opcA protein; Region: OpcA; TIGR00534
449447008534	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
449447008535	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359
449447008536	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447008537	putative active site [active]
449447008538	Phosphoglycerate kinase; Region: PGK; pfam00162
449447008539	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
449447008540	substrate binding site [chemical binding]; other site
449447008541	hinge regions; other site
449447008542	ADP binding site [chemical binding]; other site
449447008543	catalytic site [active]
449447008544	Photosystem I reaction centre subunit XI; Region: PsaL; cl03651
449447008545	Photosystem I reaction centre subunit VIII; Region: PSI_8; cl08205
449447008546	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
449447008547	GAF domain; Region: GAF; cl15785
449447008548	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447008549	dimer interface [polypeptide binding]; other site
449447008550	phosphorylation site [posttranslational modification]
449447008551	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447008552	ATP binding site [chemical binding]; other site
449447008553	Mg2+ binding site [ion binding]; other site
449447008554	G-X-G motif; other site
449447008555	Response regulator receiver domain; Region: Response_reg; pfam00072
449447008556	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447008557	active site
449447008558	phosphorylation site [posttranslational modification]
449447008559	intermolecular recognition site; other site
449447008560	dimerization interface [polypeptide binding]; other site
449447008561	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
449447008562	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
449447008563	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
449447008564	Predicted ATPases [General function prediction only]; Region: COG1106
449447008565	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447008566	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
449447008567	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447008568	Predicted ATPase [General function prediction only]; Region: COG4637
449447008569	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447008570	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
449447008571	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
449447008572	23S rRNA interface [nucleotide binding]; other site
449447008573	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
449447008574	Photosystem II reaction centre T protein; Region: PsbT; cl11601
449447008575	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
449447008576	ATP cone domain; Region: ATP-cone; pfam03477
449447008577	30S ribosomal protein S1; Reviewed; Region: PRK07400
449447008578	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
449447008579	RNA binding site [nucleotide binding]; other site
449447008580	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
449447008581	RNA binding site [nucleotide binding]; other site
449447008582	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688
449447008583	RNA binding site [nucleotide binding]; other site
449447008584	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
449447008585	phosphopeptide binding site; other site
449447008586	cyclase homology domain; Region: CHD; cd07302
449447008587	nucleotidyl binding site; other site
449447008588	metal binding site [ion binding]; metal-binding site
449447008589	dimer interface [polypeptide binding]; other site
449447008590	Protein of unknown function (DUF3120); Region: DUF3120; pfam11318
449447008591	Type IV pilus biogenesis; Region: Pilus_PilP; cl11837
449447008592	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
449447008593	Protein of unknown function (DUF2854); Region: DUF2854; pfam11016
449447008594	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
449447008595	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
449447008596	Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403
449447008597	Mechanosensitive ion channel; Region: MS_channel; pfam00924
449447008598	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
449447008599	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
449447008600	YcfA-like protein; Region: YcfA; cl00752
449447008601	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447008602	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447008603	binding surface
449447008604	TPR motif; other site
449447008605	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447008606	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447008607	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
449447008608	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447008609	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447008610	binding surface
449447008611	TPR motif; other site
449447008612	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447008613	Helix-turn-helix domains; Region: HTH; cl00088
449447008614	Winged helix-turn helix; Region: HTH_29; pfam13551
449447008615	Helix-turn-helix domains; Region: HTH; cl00088
449447008616	Integrase core domain; Region: rve; cl01316
449447008617	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447008618	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447008619	binding surface
449447008620	TPR motif; other site
449447008621	YcfA-like protein; Region: YcfA; cl00752
449447008622	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
449447008623	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
449447008624	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
449447008625	YcfA-like protein; Region: YcfA; cl00752
449447008626	prolyl-tRNA synthetase; Provisional; Region: PRK09194
449447008627	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779
449447008628	dimer interface [polypeptide binding]; other site
449447008629	motif 1; other site
449447008630	active site
449447008631	motif 2; other site
449447008632	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
449447008633	putative deacylase active site [active]
449447008634	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
449447008635	active site
449447008636	motif 3; other site
449447008637	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
449447008638	anticodon binding site; other site
449447008639	Helix-turn-helix domains; Region: HTH; cl00088
449447008640	Helix-turn-helix domains; Region: HTH; cl00088
449447008641	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447008642	Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326
449447008643	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
449447008644	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
449447008645	active site
449447008646	substrate binding site [chemical binding]; other site
449447008647	metal binding site [ion binding]; metal-binding site
449447008648	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
449447008649	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
449447008650	Cysteine-rich domain; Region: CCG; pfam02754
449447008651	Cysteine-rich domain; Region: CCG; pfam02754
449447008652	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
449447008653	FAD binding domain; Region: FAD_binding_4; pfam01565
449447008654	aspartate aminotransferase; Provisional; Region: PRK05942
449447008655	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
449447008656	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447008657	homodimer interface [polypeptide binding]; other site
449447008658	catalytic residue [active]
449447008659	hypothetical protein; Reviewed; Region: PRK00024
449447008660	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
449447008661	MPN+ (JAMM) motif; other site
449447008662	Zinc-binding site [ion binding]; other site
449447008663	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
449447008664	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
449447008665	dimerization interface [polypeptide binding]; other site
449447008666	putative ATP binding site [chemical binding]; other site
449447008667	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447008668	alpha-glucosidase; Provisional; Region: PRK10137
449447008669	Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200
449447008670	FO synthase subunit 2; Reviewed; Region: PRK07360
449447008671	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447008672	FeS/SAM binding site; other site
449447008673	Thylakoid formation protein; Region: ThylakoidFormat; cl12138
449447008674	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
449447008675	SmpB-tmRNA interface; other site
449447008676	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
449447008677	Stress-induced bacterial acidophilic repeat motif; Region: KGG; pfam10685
449447008678	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447008679	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447008680	Integrase core domain; Region: rve; cl01316
449447008681	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
449447008682	Protein of unknown function (DUF4101); Region: DUF4101; pfam13355
449447008683	Probable transposase; Region: OrfB_IS605; pfam01385
449447008684	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447008685	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447008686	pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149
449447008687	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
449447008688	tetramer interface [polypeptide binding]; other site
449447008689	TPP-binding site [chemical binding]; other site
449447008690	heterodimer interface [polypeptide binding]; other site
449447008691	phosphorylation loop region [posttranslational modification]
449447008692	Probable transposase; Region: OrfB_IS605; pfam01385
449447008693	Probable transposase; Region: OrfB_IS605; pfam01385
449447008694	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447008695	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447008696	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
449447008697	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447008698	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447008699	Probable transposase; Region: OrfB_IS605; pfam01385
449447008700	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447008701	Transposase IS200 like; Region: Y1_Tnp; cl00848
449447008702	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
449447008703	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447008704	active site
449447008705	phosphorylation site [posttranslational modification]
449447008706	intermolecular recognition site; other site
449447008707	dimerization interface [polypeptide binding]; other site
449447008708	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447008709	dimer interface [polypeptide binding]; other site
449447008710	phosphorylation site [posttranslational modification]
449447008711	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447008712	ATP binding site [chemical binding]; other site
449447008713	Mg2+ binding site [ion binding]; other site
449447008714	G-X-G motif; other site
449447008715	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
449447008716	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
449447008717	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
449447008718	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
449447008719	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
449447008720	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
449447008721	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
449447008722	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
449447008723	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
449447008724	active site
449447008725	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
449447008726	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
449447008727	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
449447008728	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
449447008729	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
449447008730	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447008731	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447008732	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
449447008733	hypothetical protein; Provisional; Region: PRK11479
449447008734	XisH protein; Region: XisH; pfam08814
449447008735	XisI protein; Region: XisI; pfam08869
449447008736	Ycf4; Region: Ycf4; cl03567
449447008737	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
449447008738	active site
449447008739	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
449447008740	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952
449447008741	dimer interface [polypeptide binding]; other site
449447008742	active site
449447008743	DNA primase; Validated; Region: dnaG; PRK05667
449447008744	CHC2 zinc finger; Region: zf-CHC2; cl15369
449447008745	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
449447008746	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
449447008747	active site
449447008748	metal binding site [ion binding]; metal-binding site
449447008749	interdomain interaction site; other site
449447008750	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
449447008751	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
449447008752	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
449447008753	active site
449447008754	Substrate binding site; other site
449447008755	Mg++ binding site; other site
449447008756	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
449447008757	putative trimer interface [polypeptide binding]; other site
449447008758	putative CoA binding site [chemical binding]; other site
449447008759	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447008760	Probable transposase; Region: OrfB_IS605; pfam01385
449447008761	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447008762	Protein of unknown function (DUF4090); Region: DUF4090; pfam13319
449447008763	Helix-turn-helix domains; Region: HTH; cl00088
449447008764	Peptidase family M48; Region: Peptidase_M48; cl12018
449447008765	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
449447008766	catalytic triad [active]
449447008767	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
449447008768	rRNA interaction site [nucleotide binding]; other site
449447008769	S8 interaction site; other site
449447008770	putative laminin-1 binding site; other site
449447008771	elongation factor Ts; Reviewed; Region: tsf; PRK12332
449447008772	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
449447008773	Elongation factor TS; Region: EF_TS; pfam00889
449447008774	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
449447008775	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
449447008776	Active site cavity [active]
449447008777	catalytic acid [active]
449447008778	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
449447008779	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447008780	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
449447008781	Protein of unknown function (DUF3288); Region: DUF3288; pfam11691
449447008782	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
449447008783	active site
449447008784	ribulose/triose binding site [chemical binding]; other site
449447008785	phosphate binding site [ion binding]; other site
449447008786	substrate (anthranilate) binding pocket [chemical binding]; other site
449447008787	product (indole) binding pocket [chemical binding]; other site
449447008788	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
449447008789	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
449447008790	homodimer interface [polypeptide binding]; other site
449447008791	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447008792	catalytic residue [active]
449447008793	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
449447008794	putative peptidoglycan binding site; other site
449447008795	Peptidase family M23; Region: Peptidase_M23; pfam01551
449447008796	homoserine dehydrogenase; Provisional; Region: PRK06349
449447008797	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447008798	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
449447008799	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
449447008800	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
449447008801	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
449447008802	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
449447008803	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447008804	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
449447008805	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447008806	Walker A motif; other site
449447008807	ATP binding site [chemical binding]; other site
449447008808	Walker B motif; other site
449447008809	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447008810	Helix-turn-helix domains; Region: HTH; cl00088
449447008811	Integrase core domain; Region: rve; cl01316
449447008812	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
449447008813	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
449447008814	alpha-gamma subunit interface [polypeptide binding]; other site
449447008815	beta-gamma subunit interface [polypeptide binding]; other site
449447008816	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
449447008817	gamma-beta subunit interface [polypeptide binding]; other site
449447008818	alpha-beta subunit interface [polypeptide binding]; other site
449447008819	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
449447008820	RNA polymerase sigma factor SigD; Validated; Region: PRK07405
449447008821	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
449447008822	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
449447008823	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
449447008824	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
449447008825	DNA binding residues [nucleotide binding]
449447008826	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447008827	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447008828	Probable transposase; Region: OrfB_IS605; pfam01385
449447008829	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447008830	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
449447008831	catalytic loop [active]
449447008832	iron binding site [ion binding]; other site
449447008833	Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452
449447008834	Flavoprotein; Region: Flavoprotein; cl08021
449447008835	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
449447008836	Protein of unknown function (DUF1517); Region: DUF1517; cl01807
449447008837	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
449447008838	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447008839	NAD(P) binding site [chemical binding]; other site
449447008840	active site
449447008841	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447008842	YcfA-like protein; Region: YcfA; cl00752
449447008843	Domain of unknown function (DUF1902); Region: DUF1902; pfam08972
449447008844	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447008845	putative active site [active]
449447008846	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
449447008847	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447008848	Tetratricopeptide repeat; Region: TPR_10; pfam13374
449447008849	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447008850	Tetratricopeptide repeat; Region: TPR_10; pfam13374
449447008851	Tetratricopeptide repeat; Region: TPR_10; pfam13374
449447008852	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447008853	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447008854	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447008855	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447008856	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447008857	Integrase core domain; Region: rve; cl01316
449447008858	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447008859	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447008860	Helix-turn-helix domains; Region: HTH; cl00088
449447008861	Helix-turn-helix domains; Region: HTH; cl00088
449447008862	Integrase core domain; Region: rve; cl01316
449447008863	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447008864	Integrase core domain; Region: rve; cl01316
449447008865	Winged helix-turn helix; Region: HTH_29; pfam13551
449447008866	Helix-turn-helix domains; Region: HTH; cl00088
449447008867	Helix-turn-helix domains; Region: HTH; cl00088
449447008868	Integrase core domain; Region: rve; cl01316
449447008869	Winged helix-turn helix; Region: HTH_29; pfam13551
449447008870	Helix-turn-helix domains; Region: HTH; cl00088
449447008871	Helix-turn-helix domains; Region: HTH; cl00088
449447008872	Transposase IS200 like; Region: Y1_Tnp; cl00848
449447008873	Protein of unknown function (DUF433); Region: DUF433; cl01030
449447008874	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447008875	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447008876	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
449447008877	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
449447008878	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
449447008879	HIGH motif; other site
449447008880	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
449447008881	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
449447008882	active site
449447008883	KMSKS motif; other site
449447008884	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
449447008885	tRNA binding surface [nucleotide binding]; other site
449447008886	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
449447008887	BON domain; Region: BON; cl02771
449447008888	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
449447008889	Cysteine-rich domain; Region: CCG; pfam02754
449447008890	Cysteine-rich domain; Region: CCG; pfam02754
449447008891	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
449447008892	anti sigma factor interaction site; other site
449447008893	regulatory phosphorylation site [posttranslational modification]; other site
449447008894	Transposase; Region: DEDD_Tnp_IS110; pfam01548
449447008895	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
449447008896	Protein of unknown function (DUF790); Region: DUF790; pfam05626
449447008897	Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372
449447008898	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
449447008899	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
449447008900	putative dimer interface [polypeptide binding]; other site
449447008901	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
449447008902	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447008903	putative active site [active]
449447008904	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
449447008905	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
449447008906	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447008907	Probable transposase; Region: OrfB_IS605; pfam01385
449447008908	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447008909	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447008910	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
449447008911	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447008912	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
449447008913	metal ion-dependent adhesion site (MIDAS); other site
449447008914	Domain of unknown function (DUF1824); Region: DUF1824; pfam08854
449447008915	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
449447008916	substrate binding site; other site
449447008917	dimer interface; other site
449447008918	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
449447008919	active site
449447008920	substrate binding site [chemical binding]; other site
449447008921	trimer interface [polypeptide binding]; other site
449447008922	CoA binding site [chemical binding]; other site
449447008923	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
449447008924	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
449447008925	active site
449447008926	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
449447008927	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
449447008928	substrate binding site [chemical binding]; other site
449447008929	oxyanion hole (OAH) forming residues; other site
449447008930	trimer interface [polypeptide binding]; other site
449447008931	RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590
449447008932	RNA/DNA binding site [nucleotide binding]; other site
449447008933	RRM dimerization site [polypeptide binding]; other site
449447008934	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
449447008935	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447008936	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
449447008937	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447008938	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519
449447008939	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
449447008940	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
449447008941	putative catalytic site [active]
449447008942	putative metal binding site [ion binding]; other site
449447008943	putative phosphate binding site [ion binding]; other site
449447008944	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
449447008945	active site
449447008946	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
449447008947	Amidase; Region: Amidase; cl11426
449447008948	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
449447008949	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
449447008950	Walker A/P-loop; other site
449447008951	ATP binding site [chemical binding]; other site
449447008952	Q-loop/lid; other site
449447008953	ABC transporter signature motif; other site
449447008954	Walker B; other site
449447008955	D-loop; other site
449447008956	H-loop/switch region; other site
449447008957	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
449447008958	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
449447008959	Walker A/P-loop; other site
449447008960	ATP binding site [chemical binding]; other site
449447008961	Q-loop/lid; other site
449447008962	ABC transporter signature motif; other site
449447008963	Walker B; other site
449447008964	D-loop; other site
449447008965	H-loop/switch region; other site
449447008966	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
449447008967	S-adenosylmethionine synthetase; Validated; Region: PRK05250
449447008968	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
449447008969	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
449447008970	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
449447008971	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
449447008972	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447008973	Family description; Region: UvrD_C_2; cl15862
449447008974	Domain of unknown function (DUF4308); Region: DUF4308; cl14566
449447008975	FOG: CBS domain [General function prediction only]; Region: COG0517
449447008976	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_7; cd04620
449447008977	FOG: CBS domain [General function prediction only]; Region: COG0517
449447008978	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
449447008979	Recombinase; Region: Recombinase; pfam07508
449447008980	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
449447008981	catalytic residues [active]
449447008982	FOG: CBS domain [General function prediction only]; Region: COG0517
449447008983	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
449447008984	CP12 domain; Region: CP12; cl14670
449447008985	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
449447008986	oligomerisation interface [polypeptide binding]; other site
449447008987	mobile loop; other site
449447008988	roof hairpin; other site
449447008989	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
449447008990	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
449447008991	ring oligomerisation interface [polypeptide binding]; other site
449447008992	ATP/Mg binding site [chemical binding]; other site
449447008993	stacking interactions; other site
449447008994	hinge regions; other site
449447008995	Transposase domain (DUF772); Region: DUF772; cl15789
449447008996	Transposase domain (DUF772); Region: DUF772; cl15789
449447008997	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447008998	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447008999	TPR motif; other site
449447009000	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447009001	binding surface
449447009002	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447009003	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447009004	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447009005	YcfA-like protein; Region: YcfA; cl00752
449447009006	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
449447009007	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
449447009008	Domain of unknown function (DUF2357); Region: DUF2357; pfam09823
449447009009	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
449447009010	Recombinase; Region: Recombinase; pfam07508
449447009011	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
449447009012	magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383
449447009013	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
449447009014	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
449447009015	Phycobilisome protein; Region: Phycobilisome; cl08227
449447009016	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
449447009017	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
449447009018	glutathione reductase; Validated; Region: PRK06116
449447009019	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
449447009020	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
449447009021	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
449447009022	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
449447009023	glycogen synthase; Provisional; Region: glgA; PRK00654
449447009024	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
449447009025	ADP-binding pocket [chemical binding]; other site
449447009026	homodimer interface [polypeptide binding]; other site
449447009027	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
449447009028	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
449447009029	catalytic residues [active]
449447009030	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
449447009031	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
449447009032	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
449447009033	active site
449447009034	metal binding site [ion binding]; metal-binding site
449447009035	Cytochrome B6-F complex subunit 5; Region: PetG; cl03637
449447009036	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
449447009037	Cupin domain; Region: Cupin_2; cl09118
449447009038	Transposase domain (DUF772); Region: DUF772; cl15789
449447009039	Transposase domain (DUF772); Region: DUF772; cl15789
449447009040	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
449447009041	CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258
449447009042	NAD binding site [chemical binding]; other site
449447009043	homotetramer interface [polypeptide binding]; other site
449447009044	homodimer interface [polypeptide binding]; other site
449447009045	active site
449447009046	substrate binding site [chemical binding]; other site
449447009047	GtrA-like protein; Region: GtrA; cl00971
449447009048	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
449447009049	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
449447009050	Ligand binding site; other site
449447009051	Putative Catalytic site; other site
449447009052	DXD motif; other site
449447009053	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447009054	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447009055	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
449447009056	CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258
449447009057	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
449447009058	NAD binding site [chemical binding]; other site
449447009059	homotetramer interface [polypeptide binding]; other site
449447009060	homodimer interface [polypeptide binding]; other site
449447009061	active site
449447009062	substrate binding site [chemical binding]; other site
449447009063	Type III pantothenate kinase; Region: Pan_kinase; cl09130
449447009064	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
449447009065	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
449447009066	putative active site [active]
449447009067	putative metal binding site [ion binding]; other site
449447009068	LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542
449447009069	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
449447009070	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447009071	homodimer interface [polypeptide binding]; other site
449447009072	catalytic residue [active]
449447009073	Protein of unknown function (DUF2839); Region: DUF2839; pfam10999
449447009074	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
449447009075	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
449447009076	putative NAD(P) binding site [chemical binding]; other site
449447009077	active site
449447009078	UDP-glucose 4-epimerase C-term subunit; Region: Epimerase_Csub; pfam13950
449447009079	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447009080	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447009081	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
449447009082	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
449447009083	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
449447009084	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
449447009085	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
449447009086	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
449447009087	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
449447009088	diiron binding motif [ion binding]; other site
449447009089	Peptidase family M48; Region: Peptidase_M48; cl12018
449447009090	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
449447009091	Moco binding site; other site
449447009092	metal coordination site [ion binding]; other site
449447009093	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447009094	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447009095	TPR motif; other site
449447009096	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447009097	binding surface
449447009098	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447009099	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447009100	binding surface
449447009101	TPR motif; other site
449447009102	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447009103	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447009104	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
449447009105	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447009106	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447009107	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447009108	Transposase [DNA replication, recombination, and repair]; Region: COG5433
449447009109	BolA-like protein; Region: BolA; cl00386
449447009110	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447009111	putative active site [active]
449447009112	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447009113	putative active site [active]
449447009114	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
449447009115	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186
449447009116	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
449447009117	homodimer interface [polypeptide binding]; other site
449447009118	NADP binding site [chemical binding]; other site
449447009119	substrate binding site [chemical binding]; other site
449447009120	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
449447009121	generic binding surface II; other site
449447009122	generic binding surface I; other site
449447009123	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
449447009124	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682
449447009125	nudix motif; other site
449447009126	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
449447009127	C-terminal peptidase (prc); Region: prc; TIGR00225
449447009128	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
449447009129	protein binding site [polypeptide binding]; other site
449447009130	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
449447009131	Catalytic dyad [active]
449447009132	recombination protein RecR; Reviewed; Region: recR; PRK00076
449447009133	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
449447009134	RecR protein; Region: RecR; pfam02132
449447009135	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
449447009136	putative active site [active]
449447009137	putative metal-binding site [ion binding]; other site
449447009138	tetramer interface [polypeptide binding]; other site
449447009139	Domain of unknown function (DUF4330); Region: DUF4330; pfam14221
449447009140	arginine decarboxylase; Provisional; Region: PRK05354
449447009141	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
449447009142	dimer interface [polypeptide binding]; other site
449447009143	active site
449447009144	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
449447009145	catalytic residues [active]
449447009146	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
449447009147	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
449447009148	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
449447009149	Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051
449447009150	catalytic site [active]
449447009151	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
449447009152	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447009153	Integrase core domain; Region: rve; cl01316
449447009154	Helix-turn-helix domains; Region: HTH; cl00088
449447009155	Exoribonuclease R [Transcription]; Region: VacB; COG0557
449447009156	RNB domain; Region: RNB; pfam00773
449447009157	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447009158	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447009159	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
449447009160	Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085
449447009161	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
449447009162	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
449447009163	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
449447009164	Domain of unknown function DUF20; Region: UPF0118; pfam01594
449447009165	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
449447009166	dimer interface [polypeptide binding]; other site
449447009167	substrate binding site [chemical binding]; other site
449447009168	metal binding sites [ion binding]; metal-binding site
449447009169	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
449447009170	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
449447009171	putative active site cavity [active]
449447009172	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
449447009173	[2Fe-2S] cluster binding site [ion binding]; other site
449447009174	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
449447009175	hydrophobic ligand binding site; other site
449447009176	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447009177	Domain of unknown function (DUF4338); Region: DUF4338; pfam14236
449447009178	AAA-like domain; Region: AAA_10; pfam12846
449447009179	NurA domain; Region: NurA; cl09134
449447009180	Arginase family; Region: Arginase; cl00306
449447009181	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
449447009182	DNA-sulfur modification-associated; Region: DndB; cl14002
449447009183	Protein of unknown function (DUF433); Region: DUF433; cl01030
449447009184	Arginase family; Region: Arginase; cl00306
449447009185	Protein of unknown function DUF86; Region: DUF86; cl01031
449447009186	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
449447009187	active site
449447009188	NTP binding site [chemical binding]; other site
449447009189	metal binding triad [ion binding]; metal-binding site
449447009190	antibiotic binding site [chemical binding]; other site
449447009191	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
449447009192	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
449447009193	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
449447009194	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
449447009195	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
449447009196	Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627
449447009197	Photosystem I reaction centre subunit IX / PsaJ; Region: PSI_PsaJ; cl03320
449447009198	Protein of unknown function (DUF3148); Region: DUF3148; pfam11347
449447009199	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447009200	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
449447009201	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
449447009202	active site
449447009203	NTP binding site [chemical binding]; other site
449447009204	metal binding triad [ion binding]; metal-binding site
449447009205	antibiotic binding site [chemical binding]; other site
449447009206	Protein of unknown function DUF86; Region: DUF86; cl01031
449447009207	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
449447009208	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
449447009209	substrate binding pocket [chemical binding]; other site
449447009210	membrane-bound complex binding site; other site
449447009211	hinge residues; other site
449447009212	Transposase; Region: DEDD_Tnp_IS110; pfam01548
449447009213	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
449447009214	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243
449447009215	Protein of unknown function (DUF2605); Region: DUF2605; pfam10792
449447009216	Protein of unknown function (DUF2973); Region: DUF2973; pfam11189
449447009217	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
449447009218	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
449447009219	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
449447009220	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447009221	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447009222	Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224
449447009223	Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224
449447009224	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447009225	Dynamin family; Region: Dynamin_N; pfam00350
449447009226	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
449447009227	G3 box; other site
449447009228	Switch II region; other site
449447009229	G4 box; other site
449447009230	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447009231	Dynamin family; Region: Dynamin_N; pfam00350
449447009232	G1 box; other site
449447009233	GTP/Mg2+ binding site [chemical binding]; other site
449447009234	G2 box; other site
449447009235	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447009236	G3 box; other site
449447009237	Switch II region; other site
449447009238	G4 box; other site
449447009239	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447009240	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447009241	Integrase core domain; Region: rve; cl01316
449447009242	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
449447009243	Transposase domain (DUF772); Region: DUF772; cl15789
449447009244	Transposase domain (DUF772); Region: DUF772; cl15789
449447009245	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447009246	Walker A/P-loop; other site
449447009247	ATP binding site [chemical binding]; other site
449447009248	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447009249	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447009250	Walker A/P-loop; other site
449447009251	ATP binding site [chemical binding]; other site
449447009252	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
449447009253	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447009254	Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
449447009255	Walker A/P-loop; other site
449447009256	ATP binding site [chemical binding]; other site
449447009257	AAA domain; Region: AAA_21; pfam13304
449447009258	ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules.  The...; Region: ABC_ATPase; cd00267
449447009259	ABC transporter signature motif; other site
449447009260	Walker B; other site
449447009261	D-loop; other site
449447009262	H-loop/switch region; other site
449447009263	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
449447009264	multimerization interface [polypeptide binding]; other site
449447009265	RbcX protein; Region: RcbX; pfam02341
449447009266	ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040
449447009267	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
449447009268	homodimer interface [polypeptide binding]; other site
449447009269	active site
449447009270	heterodimer interface [polypeptide binding]; other site
449447009271	catalytic residue [active]
449447009272	metal binding site [ion binding]; metal-binding site
449447009273	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
449447009274	putative trimer interface [polypeptide binding]; other site
449447009275	putative CoA binding site [chemical binding]; other site
449447009276	Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710
449447009277	trimer interface [polypeptide binding]; other site
449447009278	active site
449447009279	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
449447009280	putative multimerization interface [polypeptide binding]; other site
449447009281	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
449447009282	putative multimerization interface [polypeptide binding]; other site
449447009283	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
449447009284	putative multimerization interface [polypeptide binding]; other site
449447009285	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
449447009286	putative multimerization interface [polypeptide binding]; other site
449447009287	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
449447009288	Hexamer/Pentamer interface [polypeptide binding]; other site
449447009289	central pore; other site
449447009290	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
449447009291	Hexamer interface [polypeptide binding]; other site
449447009292	Hexagonal pore residue; other site
449447009293	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
449447009294	Hexamer interface [polypeptide binding]; other site
449447009295	Hexagonal pore residue; other site
449447009296	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333
449447009297	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
449447009298	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447009299	FeS/SAM binding site; other site
449447009300	TRAM domain; Region: TRAM; cl01282
449447009301	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
449447009302	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447009303	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447009304	Switch II region; other site
449447009305	G4 box; other site
449447009306	Domain of unknown function (DUF697); Region: DUF697; cl12064
449447009307	Helix-turn-helix domains; Region: HTH; cl00088
449447009308	Winged helix-turn helix; Region: HTH_29; pfam13551
449447009309	Winged helix-turn helix; Region: HTH_33; pfam13592
449447009310	Integrase core domain; Region: rve; cl01316
449447009311	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447009312	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
449447009313	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
449447009314	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447009315	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
449447009316	PAS fold; Region: PAS_4; pfam08448
449447009317	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
449447009318	GAF domain; Region: GAF; cl15785
449447009319	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
449447009320	GAF domain; Region: GAF; cl15785
449447009321	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447009322	dimer interface [polypeptide binding]; other site
449447009323	phosphorylation site [posttranslational modification]
449447009324	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447009325	ATP binding site [chemical binding]; other site
449447009326	Mg2+ binding site [ion binding]; other site
449447009327	G-X-G motif; other site
449447009328	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
449447009329	PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388
449447009330	aromatic acid decarboxylase; Validated; Region: PRK05920
449447009331	Flavoprotein; Region: Flavoprotein; cl08021
449447009332	acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100
449447009333	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
449447009334	putative valine binding site [chemical binding]; other site
449447009335	dimer interface [polypeptide binding]; other site
449447009336	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
449447009337	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
449447009338	phosphopeptide binding site; other site
449447009339	Transglycosylase; Region: Transgly; cl07896
449447009340	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
449447009341	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
449447009342	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
449447009343	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
449447009344	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
449447009345	putative di-iron ligands [ion binding]; other site
449447009346	DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191
449447009347	Helix-turn-helix domains; Region: HTH; cl00088
449447009348	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
449447009349	CHAT domain; Region: CHAT; pfam12770
449447009350	TPR repeat; Region: TPR_11; pfam13414
449447009351	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
449447009352	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
449447009353	putative ligand binding site [chemical binding]; other site
449447009354	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
449447009355	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
449447009356	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
449447009357	putative ligand binding site [chemical binding]; other site
449447009358	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
449447009359	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447009360	active site
449447009361	phosphorylation site [posttranslational modification]
449447009362	intermolecular recognition site; other site
449447009363	dimerization interface [polypeptide binding]; other site
449447009364	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
449447009365	DNA binding site [nucleotide binding]
449447009366	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
449447009367	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447009368	ATP binding site [chemical binding]; other site
449447009369	Mg2+ binding site [ion binding]; other site
449447009370	G-X-G motif; other site
449447009371	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
449447009372	anchoring element; other site
449447009373	dimer interface [polypeptide binding]; other site
449447009374	ATP binding site [chemical binding]; other site
449447009375	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
449447009376	active site
449447009377	putative metal-binding site [ion binding]; other site
449447009378	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
449447009379	Protein of unknown function (DUF497); Region: DUF497; cl01108
449447009380	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
449447009381	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
449447009382	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
449447009383	catalytic residue [active]
449447009384	RecB family nuclease, putative, TM0106 family; Region: TIGR03491
449447009385	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
449447009386	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
449447009387	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
449447009388	intersubunit interface [polypeptide binding]; other site
449447009389	active site
449447009390	Zn2+ binding site [ion binding]; other site
449447009391	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
449447009392	Mrr N-terminal domain; Region: Mrr_N; pfam14338
449447009393	Restriction endonuclease; Region: Mrr_cat; cl00516
449447009394	CpeS-like protein; Region: CpeS; pfam09367
449447009395	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
449447009396	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
449447009397	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
449447009398	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
449447009399	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
449447009400	Ligand Binding Site [chemical binding]; other site
449447009401	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
449447009402	Ligand Binding Site [chemical binding]; other site
449447009403	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447009404	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447009405	Transposase domain (DUF772); Region: DUF772; cl15789
449447009406	Protein of unknown function (DUF1036); Region: DUF1036; cl02296
449447009407	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
449447009408	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
449447009409	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
449447009410	Walker A/P-loop; other site
449447009411	ATP binding site [chemical binding]; other site
449447009412	Q-loop/lid; other site
449447009413	ABC transporter signature motif; other site
449447009414	Walker B; other site
449447009415	D-loop; other site
449447009416	H-loop/switch region; other site
449447009417	ABC-2 type transporter; Region: ABC2_membrane; cl11417
449447009418	Retropepsins; pepsin-like aspartate proteases; Region: retropepsin_like; cd00303
449447009419	inhibitor binding site; inhibition site
449447009420	catalytic motif [active]
449447009421	Catalytic residue [active]
449447009422	Active site flap [active]
449447009423	Protein of unknown function (DUF433); Region: DUF433; cl01030
449447009424	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
449447009425	YcfA-like protein; Region: YcfA; cl00752
449447009426	Winged helix-turn helix; Region: HTH_29; pfam13551
449447009427	Helix-turn-helix domains; Region: HTH; cl00088
449447009428	Winged helix-turn helix; Region: HTH_33; pfam13592
449447009429	Integrase core domain; Region: rve; cl01316
449447009430	Transposase IS200 like; Region: Y1_Tnp; cl00848
449447009431	Probable transposase; Region: OrfB_IS605; pfam01385
449447009432	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447009433	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
449447009434	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
449447009435	trmE is a tRNA modification GTPase; Region: trmE; cd04164
449447009436	G1 box; other site
449447009437	GTP/Mg2+ binding site [chemical binding]; other site
449447009438	Switch I region; other site
449447009439	G2 box; other site
449447009440	Switch II region; other site
449447009441	G3 box; other site
449447009442	G4 box; other site
449447009443	G5 box; other site
449447009444	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
449447009445	Protein of unknown function (DUF1664); Region: DUF1664; pfam07889
449447009446	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
449447009447	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447009448	Probable transposase; Region: OrfB_IS605; pfam01385
449447009449	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447009450	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
449447009451	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
449447009452	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
449447009453	putative active site [active]
449447009454	putative NTP binding site [chemical binding]; other site
449447009455	putative nucleic acid binding site [nucleotide binding]; other site
449447009456	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
449447009457	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
449447009458	active site
449447009459	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
449447009460	alanine racemase; Reviewed; Region: alr; PRK00053
449447009461	active site
449447009462	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
449447009463	dimer interface [polypeptide binding]; other site
449447009464	substrate binding site [chemical binding]; other site
449447009465	catalytic residues [active]
449447009466	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
449447009467	Cytochrome P450; Region: p450; pfam00067
449447009468	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
449447009469	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
449447009470	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
449447009471	active site
449447009472	ATP binding site [chemical binding]; other site
449447009473	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
449447009474	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
449447009475	Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
449447009476	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447009477	ABC transporter signature motif; other site
449447009478	Walker B; other site
449447009479	D-loop; other site
449447009480	H-loop/switch region; other site
449447009481	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
449447009482	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447009483	Walker A/P-loop; other site
449447009484	ATP binding site [chemical binding]; other site
449447009485	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
449447009486	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
449447009487	active site
449447009488	dinuclear metal binding site [ion binding]; other site
449447009489	dimerization interface [polypeptide binding]; other site
449447009490	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
449447009491	Protein of unknown function, DUF482; Region: DUF482; pfam04339
449447009492	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
449447009493	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
449447009494	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447009495	dimer interface [polypeptide binding]; other site
449447009496	phosphorylation site [posttranslational modification]
449447009497	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447009498	ATP binding site [chemical binding]; other site
449447009499	Mg2+ binding site [ion binding]; other site
449447009500	G-X-G motif; other site
449447009501	prephenate dehydratase; Provisional; Region: PRK11898
449447009502	Prephenate dehydratase; Region: PDT; pfam00800
449447009503	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
449447009504	putative L-Phe binding site [chemical binding]; other site
449447009505	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
449447009506	active site
449447009507	catalytic site [active]
449447009508	substrate binding site [chemical binding]; other site
449447009509	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
449447009510	Ligand Binding Site [chemical binding]; other site
449447009511	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
449447009512	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
449447009513	Catalytic site [active]
449447009514	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
449447009515	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
449447009516	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
449447009517	Cupin domain; Region: Cupin_2; cl09118
449447009518	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
449447009519	photosystem I assembly protein Ycf3; Provisional; Region: PRK02603
449447009520	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447009521	binding surface
449447009522	TPR motif; other site
449447009523	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
449447009524	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
449447009525	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
449447009526	active site
449447009527	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317
449447009528	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
449447009529	active site
449447009530	substrate binding site [chemical binding]; other site
449447009531	metal binding site [ion binding]; metal-binding site
449447009532	RRXRR protein; Region: RRXRR; pfam14239
449447009533	O-Antigen ligase; Region: Wzy_C; cl04850
449447009534	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
449447009535	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
449447009536	active site
449447009537	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
449447009538	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447009539	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
449447009540	RNA polymerase sigma factor; Provisional; Region: PRK12518
449447009541	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
449447009542	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
449447009543	DNA binding residues [nucleotide binding]
449447009544	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
449447009545	dimer interface [polypeptide binding]; other site
449447009546	UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255
449447009547	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
449447009548	NAD binding site [chemical binding]; other site
449447009549	substrate binding site [chemical binding]; other site
449447009550	active site
449447009551	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
449447009552	putative active site [active]
449447009553	putative metal binding site [ion binding]; other site
449447009554	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
449447009555	Haemolysin XhlA; Region: XhlA; pfam10779
449447009556	Protein of unknown function (DUF4065); Region: DUF4065; cl01445
449447009557	Protein of unknown function (DUF4065); Region: DUF4065; cl01445
449447009558	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
449447009559	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
449447009560	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
449447009561	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
449447009562	putative catalytic cysteine [active]
449447009563	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
449447009564	putative active site [active]
449447009565	metal binding site [ion binding]; metal-binding site
449447009566	AAA domain; Region: AAA_21; pfam13304
449447009567	phycobillisome linker protein; Region: apcE; CHL00091
449447009568	Phycobilisome protein; Region: Phycobilisome; cl08227
449447009569	Phycobilisome protein; Region: Phycobilisome; cl08227
449447009570	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
449447009571	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
449447009572	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
449447009573	CutA1 divalent ion tolerance protein; Region: CutA1; cl00584
449447009574	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
449447009575	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
449447009576	ligand binding site [chemical binding]; other site
449447009577	flexible hinge region; other site
449447009578	Helix-turn-helix domains; Region: HTH; cl00088
449447009579	Protein of unknown function (DUF4101); Region: DUF4101; pfam13355
449447009580	GTPase RsgA; Reviewed; Region: PRK12289
449447009581	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
449447009582	RNA binding site [nucleotide binding]; other site
449447009583	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
449447009584	GTPase/Zn-binding domain interface [polypeptide binding]; other site
449447009585	GTP/Mg2+ binding site [chemical binding]; other site
449447009586	G4 box; other site
449447009587	G5 box; other site
449447009588	G1 box; other site
449447009589	Switch I region; other site
449447009590	G2 box; other site
449447009591	G3 box; other site
449447009592	Switch II region; other site
449447009593	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
449447009594	CPxP  motif; other site
449447009595	chaperone protein DnaJ; Provisional; Region: PRK14293
449447009596	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
449447009597	HSP70 interaction site [polypeptide binding]; other site
449447009598	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
449447009599	substrate binding site [polypeptide binding]; other site
449447009600	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
449447009601	Zn binding sites [ion binding]; other site
449447009602	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
449447009603	dimer interface [polypeptide binding]; other site
449447009604	molecular chaperone DnaK; Provisional; Region: PRK13411
449447009605	Cell division protein FtsA; Region: FtsA; cl11496
449447009606	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
449447009607	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
449447009608	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
449447009609	putative NAD(P) binding site [chemical binding]; other site
449447009610	putative substrate binding site [chemical binding]; other site
449447009611	catalytic Zn binding site [ion binding]; other site
449447009612	structural Zn binding site [ion binding]; other site
449447009613	dimer interface [polypeptide binding]; other site
449447009614	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447009615	putative active site [active]
449447009616	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
449447009617	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
449447009618	putative substrate binding site [chemical binding]; other site
449447009619	putative ATP binding site [chemical binding]; other site
449447009620	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447009621	aspartate kinase; Provisional; Region: PRK07431
449447009622	AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246
449447009623	putative catalytic residues [active]
449447009624	putative nucleotide binding site [chemical binding]; other site
449447009625	putative aspartate binding site [chemical binding]; other site
449447009626	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
449447009627	putative allosteric regulatory site; other site
449447009628	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
449447009629	putative allosteric regulatory residue; other site
449447009630	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
449447009631	putative allosteric regulatory site; other site
449447009632	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
449447009633	NB-ARC domain; Region: NB-ARC; pfam00931
449447009634	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447009635	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447009636	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
449447009637	Protein of unknown function (DUF433); Region: DUF433; cl01030
449447009638	Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136
449447009639	Protein of unknown function (DUF2283); Region: DUF2283; cl02251
449447009640	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
449447009641	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447009642	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
449447009643	cofactor binding site; other site
449447009644	DNA binding site [nucleotide binding]
449447009645	substrate interaction site [chemical binding]; other site
449447009646	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447009647	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
449447009648	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447009649	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447009650	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
449447009651	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
449447009652	DNA binding residues [nucleotide binding]
449447009653	dimerization interface [polypeptide binding]; other site
449447009654	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
449447009655	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
449447009656	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
449447009657	cofactor binding site; other site
449447009658	DNA binding site [nucleotide binding]
449447009659	substrate interaction site [chemical binding]; other site
449447009660	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
449447009661	HflC protein; Region: hflC; TIGR01932
449447009662	Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein).  Individual proteins of this band 7 domain family may...; Region: Band_7_prohibitin; cd03401
449447009663	EVE domain; Region: EVE; cl00728
449447009664	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
449447009665	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447009666	dimer interface [polypeptide binding]; other site
449447009667	phosphorylation site [posttranslational modification]
449447009668	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447009669	ATP binding site [chemical binding]; other site
449447009670	Mg2+ binding site [ion binding]; other site
449447009671	G-X-G motif; other site
449447009672	Sulfotransferase family; Region: Sulfotransfer_3; cl14559
449447009673	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447009674	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447009675	Probable transposase; Region: OrfB_IS605; pfam01385
449447009676	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447009677	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447009678	FeS/SAM binding site; other site
449447009679	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447009680	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447009681	Probable transposase; Region: OrfB_IS605; pfam01385
449447009682	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447009683	geranylgeranyl diphosphate reductase; Provisional; Region: PLN00093
449447009684	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447009685	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447009686	poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836
449447009687	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
449447009688	Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; cl09914
449447009689	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
449447009690	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447009691	NAD(P) binding site [chemical binding]; other site
449447009692	active site
449447009693	putative acyltransferase; Provisional; Region: PRK05790
449447009694	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
449447009695	dimer interface [polypeptide binding]; other site
449447009696	active site
449447009697	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
449447009698	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
449447009699	Oxygen evolving enhancer protein 3 (PsbQ); Region: PsbQ; cl05363
449447009700	ATP synthase I chain; Region: ATP_synt_I; cl09170
449447009701	ATP synthase A chain; Region: ATP-synt_A; cl00413
449447009702	ATP synthase subunit C; Region: ATP-synt_C; cl00466
449447009703	F0F1 ATP synthase subunit B'; Validated; Region: PRK07353
449447009704	Plant ATP synthase F0; Region: YMF19; cl07975
449447009705	F0F1 ATP synthase subunit B; Validated; Region: PRK07352
449447009706	Plant ATP synthase F0; Region: YMF19; cl07975
449447009707	Plant ATP synthase F0; Region: YMF19; cl07975
449447009708	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
449447009709	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
449447009710	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
449447009711	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
449447009712	beta subunit interaction interface [polypeptide binding]; other site
449447009713	Walker A motif; other site
449447009714	ATP binding site [chemical binding]; other site
449447009715	Walker B motif; other site
449447009716	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
449447009717	ATP synthase; Region: ATP-synt; cl00365
449447009718	F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422
449447009719	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
449447009720	Calx-beta domain; Region: Calx-beta; cl02522
449447009721	Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483
449447009722	Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483
449447009723	sodium/calcium exchanger 1; Region: caca; TIGR00845
449447009724	Calx-beta domain; Region: Calx-beta; cl02522
449447009725	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
449447009726	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
449447009727	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447009728	oligomerization interface [polypeptide binding]; other site
449447009729	active site
449447009730	NAD+ binding site [chemical binding]; other site
449447009731	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
449447009732	Domain of unknown function (DUF955); Region: DUF955; cl01076
449447009733	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447009734	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
449447009735	Lumazine binding domain; Region: Lum_binding; pfam00677
449447009736	Lumazine binding domain; Region: Lum_binding; pfam00677
449447009737	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
449447009738	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
449447009739	putative catalytic cysteine [active]
449447009740	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
449447009741	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
449447009742	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
449447009743	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
449447009744	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
449447009745	Fatty acid desaturase; Region: FA_desaturase; pfam00487
449447009746	Di-iron ligands [ion binding]; other site
449447009747	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
449447009748	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
449447009749	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
449447009750	catalytic residue [active]
449447009751	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
449447009752	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
449447009753	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
449447009754	metal ion-dependent adhesion site (MIDAS); other site
449447009755	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
449447009756	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
449447009757	acyl-CoA synthetase; Validated; Region: PRK07788
449447009758	MAPEG family; Region: MAPEG; cl09190
449447009759	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
449447009760	Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze  the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443
449447009761	active site
449447009762	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
449447009763	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
449447009764	ATP-grasp domain; Region: ATP-grasp_4; cl03087
449447009765	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
449447009766	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
449447009767	ATP-grasp domain; Region: ATP-grasp_4; cl03087
449447009768	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
449447009769	IMP binding site; other site
449447009770	dimer interface [polypeptide binding]; other site
449447009771	interdomain contacts; other site
449447009772	partial ornithine binding site; other site
449447009773	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
449447009774	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
449447009775	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
449447009776	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
449447009777	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
449447009778	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
449447009779	iron-sulfur cluster binding protein, putative; Region: TIGR00276
449447009780	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
449447009781	phosphoglycolate phosphatase; Provisional; Region: PRK13225
449447009782	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
449447009783	motif II; other site
449447009784	NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716
449447009785	Protein of unknown function (DUF3007); Region: DUF3007; pfam11460
449447009786	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447009787	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
449447009788	structural tetrad; other site
449447009789	FOG: WD40 repeat [General function prediction only]; Region: COG2319
449447009790	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447009791	structural tetrad; other site
449447009792	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
449447009793	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447009794	FeS/SAM binding site; other site
449447009795	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
449447009796	Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682
449447009797	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
449447009798	ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854
449447009799	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447009800	Walker A motif; other site
449447009801	ATP binding site [chemical binding]; other site
449447009802	Walker B motif; other site
449447009803	R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645
449447009804	RxxxH motif; other site
449447009805	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
449447009806	Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617
449447009807	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
449447009808	non-specific DNA binding site [nucleotide binding]; other site
449447009809	salt bridge; other site
449447009810	sequence-specific DNA binding site [nucleotide binding]; other site
449447009811	Protein of unknown function (DUF1292); Region: DUF1292; cl01608
449447009812	Protein of unknown function (DUF3727); Region: DUF3727; pfam12527
449447009813	Survival protein SurE; Region: SurE; cl00448
449447009814	Probable transposase; Region: OrfB_IS605; pfam01385
449447009815	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447009816	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
449447009817	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447009818	S-adenosylmethionine binding site [chemical binding]; other site
449447009819	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
449447009820	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447009821	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
449447009822	putative L-serine binding site [chemical binding]; other site
449447009823	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418
449447009824	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
449447009825	PYR/PP interface [polypeptide binding]; other site
449447009826	dimer interface [polypeptide binding]; other site
449447009827	TPP binding site [chemical binding]; other site
449447009828	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
449447009829	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
449447009830	TPP-binding site [chemical binding]; other site
449447009831	dimer interface [polypeptide binding]; other site
449447009832	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
449447009833	AAA domain; Region: AAA_26; pfam13500
449447009834	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447009835	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
449447009836	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447009837	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
449447009838	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447009839	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447009840	Probable transposase; Region: OrfB_IS605; pfam01385
449447009841	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447009842	Domain of unknown function (DUF1995); Region: DUF1995; pfam09353
449447009843	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
449447009844	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
449447009845	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
449447009846	Flavin Reductases; Region: FlaRed; cl00801
449447009847	Phosphate-starvation-inducible E; Region: PsiE; cl01264
449447009848	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
449447009849	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
449447009850	Flavin Reductases; Region: FlaRed; cl00801
449447009851	Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562
449447009852	putative active site [active]
449447009853	putative catalytic triad [active]
449447009854	Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562
449447009855	Calx-beta domain; Region: Calx-beta; cl02522
449447009856	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
449447009857	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
449447009858	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
449447009859	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447009860	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447009861	Transposase [DNA replication, recombination, and repair]; Region: COG5433
449447009862	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447009863	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
449447009864	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
449447009865	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
449447009866	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447009867	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447009868	Probable transposase; Region: OrfB_IS605; pfam01385
449447009869	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447009870	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
449447009871	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447009872	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447009873	Probable transposase; Region: OrfB_IS605; pfam01385
449447009874	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447009875	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
449447009876	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
449447009877	motif II; other site
449447009878	Predicted amidohydrolase [General function prediction only]; Region: COG0388
449447009879	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
449447009880	putative active site [active]
449447009881	catalytic triad [active]
449447009882	dimer interface [polypeptide binding]; other site
449447009883	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447009884	Helix-turn-helix domains; Region: HTH; cl00088
449447009885	Integrase core domain; Region: rve; cl01316
449447009886	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
449447009887	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
449447009888	active site
449447009889	NTP binding site [chemical binding]; other site
449447009890	metal binding triad [ion binding]; metal-binding site
449447009891	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
449447009892	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
449447009893	Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718
449447009894	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
449447009895	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447009896	OstA-like protein; Region: OstA; cl00844
449447009897	Protein of unknown function (DUF3769); Region: DUF3769; pfam12600
449447009898	Photosystem II reaction centre I protein (PSII 4.8 kDa protein); Region: PsbI; cl03640
449447009899	Predicted methyltransferases [General function prediction only]; Region: COG0313
449447009900	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
449447009901	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
449447009902	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
449447009903	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
449447009904	The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218
449447009905	Walker A/P-loop; other site
449447009906	ATP binding site [chemical binding]; other site
449447009907	Q-loop/lid; other site
449447009908	ABC transporter signature motif; other site
449447009909	Walker B; other site
449447009910	D-loop; other site
449447009911	H-loop/switch region; other site
449447009912	OstA-like protein; Region: OstA; cl00844
449447009913	Domain of unknown function (DUF309); Region: DUF309; cl00667
449447009914	Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977
449447009915	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
449447009916	comF family protein; Region: comF; TIGR00201
449447009917	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
449447009918	active site
449447009919	Photosystem II reaction centre X protein (PsbX); Region: PsbX; cl05887
449447009920	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447009921	Restriction endonuclease EcoRV; Region: Endonuc-EcoRV; pfam09233
449447009922	cell division protein; Validated; Region: ftsH; CHL00176
449447009923	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447009924	Walker A motif; other site
449447009925	ATP binding site [chemical binding]; other site
449447009926	Walker B motif; other site
449447009927	arginine finger; other site
449447009928	Peptidase family M41; Region: Peptidase_M41; pfam01434
449447009929	DNA polymerase III subunit delta'; Validated; Region: PRK07399
449447009930	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
449447009931	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
449447009932	metal-binding site [ion binding]
449447009933	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
449447009934	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
449447009935	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
449447009936	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
449447009937	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
449447009938	putative active site [active]
449447009939	putative NTP binding site [chemical binding]; other site
449447009940	putative nucleic acid binding site [nucleotide binding]; other site
449447009941	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
449447009942	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
449447009943	active site
449447009944	Winged helix-turn helix; Region: HTH_29; pfam13551
449447009945	Helix-turn-helix domains; Region: HTH; cl00088
449447009946	Helix-turn-helix domains; Region: HTH; cl00088
449447009947	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447009948	Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may...; Region: GLECT; cd00070
449447009949	putative alternate dimerization interface [polypeptide binding]; other site
449447009950	sugar binding pocket [chemical binding]; other site
449447009951	Domain of unknown function (DUF1963); Region: DUF1963; cl01600
449447009952	Helix-turn-helix domains; Region: HTH; cl00088
449447009953	Winged helix-turn helix; Region: HTH_29; pfam13551
449447009954	Winged helix-turn helix; Region: HTH_33; pfam13592
449447009955	Integrase core domain; Region: rve; cl01316
449447009956	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447009957	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
449447009958	Helix-turn-helix domains; Region: HTH; cl00088
449447009959	Winged helix-turn helix; Region: HTH_29; pfam13551
449447009960	Winged helix-turn helix; Region: HTH_33; pfam13592
449447009961	Integrase core domain; Region: rve; cl01316
449447009962	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
449447009963	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
449447009964	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
449447009965	active site
449447009966	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
449447009967	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
449447009968	active site residue [active]
449447009969	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
449447009970	active site residue [active]
449447009971	Phycobilisome protein; Region: Phycobilisome; cl08227
449447009972	Phycobilisome protein; Region: Phycobilisome; cl08227
449447009973	cysteine synthase; Region: PLN02565
449447009974	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
449447009975	dimer interface [polypeptide binding]; other site
449447009976	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447009977	catalytic residue [active]
449447009978	MgtC family; Region: MgtC; pfam02308
449447009979	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
449447009980	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
449447009981	putative switch regulator; other site
449447009982	non-specific DNA interactions [nucleotide binding]; other site
449447009983	DNA binding site [nucleotide binding]
449447009984	sequence specific DNA binding site [nucleotide binding]; other site
449447009985	putative cAMP binding site [chemical binding]; other site
449447009986	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
449447009987	Cadmium resistance transporter; Region: Cad; cl04177
449447009988	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447009989	Helix-turn-helix domains; Region: HTH; cl00088
449447009990	Integrase core domain; Region: rve; cl01316
449447009991	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
449447009992	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447009993	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
449447009994	Uncharacterized conserved protein [Function unknown]; Region: COG4938
449447009995	AAA domain; Region: AAA_21; pfam13304
449447009996	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
449447009997	Winged helix-turn helix; Region: HTH_29; pfam13551
449447009998	Helix-turn-helix domains; Region: HTH; cl00088
449447009999	Winged helix-turn helix; Region: HTH_33; pfam13592
449447010000	Integrase core domain; Region: rve; cl01316
449447010001	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
449447010002	homodimer interface [polypeptide binding]; other site
449447010003	substrate-cofactor binding pocket; other site
449447010004	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447010005	catalytic residue [active]
449447010006	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447010007	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447010008	Probable transposase; Region: OrfB_IS605; pfam01385
449447010009	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447010010	cystathionine gamma-synthase; Provisional; Region: PRK07811
449447010011	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
449447010012	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
449447010013	Domain of unknown function (DUF202); Region: DUF202; cl09954
449447010014	Integral membrane protein TerC family; Region: TerC; cl10468
449447010015	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
449447010016	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447010017	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447010018	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447010019	Part of the ABC transporter complex cysAWTP involved in sulfate import.  Responsible for energy coupling to the transport system.  The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296
449447010020	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
449447010021	Walker A/P-loop; other site
449447010022	ATP binding site [chemical binding]; other site
449447010023	Q-loop/lid; other site
449447010024	ABC transporter signature motif; other site
449447010025	Walker B; other site
449447010026	D-loop; other site
449447010027	H-loop/switch region; other site
449447010028	TOBE domain; Region: TOBE_2; cl01440
449447010029	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
449447010030	Domain of unknown function (DUF202); Region: DUF202; cl09954
449447010031	Cadmium resistance transporter; Region: Cad; cl04177
449447010032	Transcriptional regulator [Transcription]; Region: LysR; COG0583
449447010033	Helix-turn-helix domains; Region: HTH; cl00088
449447010034	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
449447010035	putative dimerization interface [polypeptide binding]; other site
449447010036	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
449447010037	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447010038	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447010039	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447010040	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447010041	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
449447010042	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
449447010043	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
449447010044	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
449447010045	RNA binding surface [nucleotide binding]; other site
449447010046	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
449447010047	active site
449447010048	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447010049	Protein of unknown function (DUF2997); Region: DUF2997; pfam11211
449447010050	Protein of unknown function (DUF1257); Region: DUF1257; cl06088
449447010051	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
449447010052	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447010053	putative active site [active]
449447010054	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447010055	putative active site [active]
449447010056	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447010057	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
449447010058	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
449447010059	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
449447010060	Zn2+ binding site [ion binding]; other site
449447010061	Mg2+ binding site [ion binding]; other site
449447010062	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447010063	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447010064	Calx-beta domain; Region: Calx-beta; cl02522
449447010065	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
449447010066	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
449447010067	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346
449447010068	Proline dehydrogenase; Region: Pro_dh; cl03282
449447010069	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
449447010070	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
449447010071	Glutamate binding site [chemical binding]; other site
449447010072	homodimer interface [polypeptide binding]; other site
449447010073	NAD binding site [chemical binding]; other site
449447010074	catalytic residues [active]
449447010075	phosphoglucomutase; Region: PLN02307
449447010076	Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085
449447010077	substrate binding site [chemical binding]; other site
449447010078	dimer interface [polypeptide binding]; other site
449447010079	active site
449447010080	metal binding site [ion binding]; metal-binding site
449447010081	tellurium resistance terB-like protein; Region: terB_like; cd07177
449447010082	metal binding site [ion binding]; metal-binding site
449447010083	16S rRNA methyltransferase B; Provisional; Region: PRK14901
449447010084	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
449447010085	putative RNA binding site [nucleotide binding]; other site
449447010086	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
449447010087	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
449447010088	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
449447010089	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
449447010090	CAAX protease self-immunity; Region: Abi; cl00558
449447010091	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
449447010092	NB-ARC domain; Region: NB-ARC; pfam00931
449447010093	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447010094	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447010095	binding surface
449447010096	TPR motif; other site
449447010097	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447010098	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447010099	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447010100	binding surface
449447010101	TPR motif; other site
449447010102	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447010103	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447010104	binding surface
449447010105	TPR motif; other site
449447010106	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447010107	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
449447010108	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
449447010109	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
449447010110	23S rRNA interface [nucleotide binding]; other site
449447010111	L3 interface [polypeptide binding]; other site
449447010112	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
449447010113	PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570
449447010114	dimerization interface 3.5A [polypeptide binding]; other site
449447010115	active site
449447010116	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
449447010117	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
449447010118	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
449447010119	alphaNTD homodimer interface [polypeptide binding]; other site
449447010120	alphaNTD - beta interaction site [polypeptide binding]; other site
449447010121	alphaNTD - beta' interaction site [polypeptide binding]; other site
449447010122	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
449447010123	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
449447010124	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
449447010125	YCII-related domain; Region: YCII; cl00999
449447010126	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
449447010127	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
449447010128	FAD binding domain; Region: FAD_binding_4; pfam01565
449447010129	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
449447010130	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447010131	Creatinine amidohydrolase; Region: Creatininase; cl00618
449447010132	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
449447010133	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447010134	active site
449447010135	phosphorylation site [posttranslational modification]
449447010136	intermolecular recognition site; other site
449447010137	dimerization interface [polypeptide binding]; other site
449447010138	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
449447010139	DNA binding site [nucleotide binding]
449447010140	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
449447010141	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447010142	dimer interface [polypeptide binding]; other site
449447010143	phosphorylation site [posttranslational modification]
449447010144	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447010145	ATP binding site [chemical binding]; other site
449447010146	Mg2+ binding site [ion binding]; other site
449447010147	G-X-G motif; other site
449447010148	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
449447010149	PhoU domain; Region: PhoU; pfam01895
449447010150	PhoU domain; Region: PhoU; pfam01895
449447010151	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447010152	dimer interface [polypeptide binding]; other site
449447010153	conserved gate region; other site
449447010154	ABC-ATPase subunit interface; other site
449447010155	NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909
449447010156	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
449447010157	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
449447010158	HIGH motif; other site
449447010159	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
449447010160	active site
449447010161	KMSKS motif; other site
449447010162	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
449447010163	active site
449447010164	ADP/pyrophosphate binding site [chemical binding]; other site
449447010165	dimerization interface [polypeptide binding]; other site
449447010166	allosteric effector site; other site
449447010167	fructose-1,6-bisphosphate binding site; other site
449447010168	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447010169	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
449447010170	Restriction endonuclease BsobI; Region: Endonuc-BsobI; pfam09194
449447010171	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
449447010172	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
449447010173	Protein of unknown function (DUF4065); Region: DUF4065; cl01445
449447010174	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
449447010175	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
449447010176	TRX domain, novel NADPH thioredoxin reductase (NTR) family; composed of fusion proteins found only in oxygenic photosynthetic organisms containing both TRX and NTR domains. The TRX domain functions as a protein disulfide reductase via the reversible...; Region: TRX_NTR; cd02949
449447010177	catalytic residues [active]
449447010178	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
449447010179	ABC-ATPase subunit  interface; other site
449447010180	dimer interface [polypeptide binding]; other site
449447010181	putative PBP binding regions; other site
449447010182	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
449447010183	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
449447010184	ligand binding site [chemical binding]; other site
449447010185	flexible hinge region; other site
449447010186	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
449447010187	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
449447010188	putative active site [active]
449447010189	substrate binding site [chemical binding]; other site
449447010190	putative cosubstrate binding site; other site
449447010191	catalytic site [active]
449447010192	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
449447010193	substrate binding site [chemical binding]; other site
449447010194	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
449447010195	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
449447010196	primosome assembly protein PriA; Validated; Region: PRK05580
449447010197	primosome assembly protein PriA; Validated; Region: PRK05580
449447010198	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
449447010199	ATP binding site [chemical binding]; other site
449447010200	putative Mg++ binding site [ion binding]; other site
449447010201	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447010202	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
449447010203	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
449447010204	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
449447010205	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
449447010206	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
449447010207	DNA binding residues [nucleotide binding]
449447010208	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
449447010209	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
449447010210	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
449447010211	catalytic residue [active]
449447010212	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408
449447010213	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
449447010214	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
449447010215	DNA binding residues [nucleotide binding]
449447010216	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
449447010217	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447010218	Walker A motif; other site
449447010219	ATP binding site [chemical binding]; other site
449447010220	Walker B motif; other site
449447010221	arginine finger; other site
449447010222	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
449447010223	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
449447010224	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
449447010225	substrate binding site [chemical binding]; other site
449447010226	glutamase interaction surface [polypeptide binding]; other site
449447010227	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
449447010228	Domain of unknown function DUF20; Region: UPF0118; pfam01594
449447010229	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
449447010230	RNA/DNA hybrid binding site [nucleotide binding]; other site
449447010231	active site
449447010232	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602
449447010233	ACT domain; Region: ACT_3; pfam10000
449447010234	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
449447010235	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
449447010236	dimer interface [polypeptide binding]; other site
449447010237	[2Fe-2S] cluster binding site [ion binding]; other site
449447010238	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
449447010239	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
449447010240	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
449447010241	putative active site [active]
449447010242	putative substrate binding site [chemical binding]; other site
449447010243	putative cosubstrate binding site; other site
449447010244	catalytic site [active]
449447010245	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
449447010246	Major Facilitator Superfamily; Region: MFS_1; pfam07690
449447010247	putative substrate translocation pore; other site
449447010248	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
449447010249	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
449447010250	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447010251	Transposase domain (DUF772); Region: DUF772; cl15789
449447010252	acyl-ACP reductase; Provisional; Region: PRK14982
449447010253	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447010254	NAD(P) binding pocket [chemical binding]; other site
449447010255	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
449447010256	dinuclear metal binding motif [ion binding]; other site
449447010257	carotene 7,8-desaturase; Region: zeta_caro_desat; TIGR02732
449447010258	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447010259	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
449447010260	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447010261	binding surface
449447010262	TPR motif; other site
449447010263	TPR repeat; Region: TPR_11; pfam13414
449447010264	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
449447010265	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
449447010266	substrate binding site [chemical binding]; other site
449447010267	ligand binding site [chemical binding]; other site
449447010268	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
449447010269	Mg++ binding site [ion binding]; other site
449447010270	putative catalytic motif [active]
449447010271	putative substrate binding site [chemical binding]; other site
449447010272	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
449447010273	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
449447010274	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
449447010275	synthetase active site [active]
449447010276	NTP binding site [chemical binding]; other site
449447010277	metal binding site [ion binding]; metal-binding site
449447010278	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
449447010279	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
449447010280	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
449447010281	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
449447010282	Walker A/P-loop; other site
449447010283	ATP binding site [chemical binding]; other site
449447010284	Q-loop/lid; other site
449447010285	ABC transporter signature motif; other site
449447010286	Walker B; other site
449447010287	D-loop; other site
449447010288	H-loop/switch region; other site
449447010289	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
449447010290	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
449447010291	Walker A/P-loop; other site
449447010292	ATP binding site [chemical binding]; other site
449447010293	Q-loop/lid; other site
449447010294	ABC transporter signature motif; other site
449447010295	Walker B; other site
449447010296	D-loop; other site
449447010297	H-loop/switch region; other site
449447010298	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
449447010299	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
449447010300	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
449447010301	Probable Catalytic site; other site
449447010302	metal-binding site
449447010303	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
449447010304	Peptidase family M48; Region: Peptidase_M48; cl12018
449447010305	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
449447010306	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
449447010307	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
449447010308	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
449447010309	Walker A/P-loop; other site
449447010310	ATP binding site [chemical binding]; other site
449447010311	Q-loop/lid; other site
449447010312	ABC transporter signature motif; other site
449447010313	Walker B; other site
449447010314	D-loop; other site
449447010315	H-loop/switch region; other site
449447010316	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
449447010317	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
449447010318	Ligand Binding Site [chemical binding]; other site
449447010319	Photosystem II reaction centre M protein (PsbM); Region: PsbM; cl11459
449447010320	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447010321	dimer interface [polypeptide binding]; other site
449447010322	conserved gate region; other site
449447010323	putative PBP binding loops; other site
449447010324	ABC-ATPase subunit interface; other site
449447010325	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
449447010326	NMT1-like family; Region: NMT1_2; cl15260
449447010327	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
449447010328	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
449447010329	Walker A/P-loop; other site
449447010330	ATP binding site [chemical binding]; other site
449447010331	Q-loop/lid; other site
449447010332	ABC transporter signature motif; other site
449447010333	Walker B; other site
449447010334	D-loop; other site
449447010335	H-loop/switch region; other site
449447010336	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
449447010337	active site
449447010338	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
449447010339	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
449447010340	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
449447010341	dimer interface [polypeptide binding]; other site
449447010342	ADP-ribose binding site [chemical binding]; other site
449447010343	active site
449447010344	nudix motif; other site
449447010345	metal binding site [ion binding]; metal-binding site
449447010346	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
449447010347	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
449447010348	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
449447010349	RNase E interface [polypeptide binding]; other site
449447010350	trimer interface [polypeptide binding]; other site
449447010351	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
449447010352	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
449447010353	RNase E interface [polypeptide binding]; other site
449447010354	trimer interface [polypeptide binding]; other site
449447010355	active site
449447010356	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
449447010357	putative nucleic acid binding region [nucleotide binding]; other site
449447010358	G-X-X-G motif; other site
449447010359	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
449447010360	RNA binding site [nucleotide binding]; other site
449447010361	domain interface; other site
449447010362	peptide chain release factor 1; Validated; Region: prfA; PRK00591
449447010363	RF-1 domain; Region: RF-1; cl02875
449447010364	RF-1 domain; Region: RF-1; cl02875
449447010365	Probable transposase; Region: OrfB_IS605; pfam01385
449447010366	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447010367	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
449447010368	heterotetramer interface [polypeptide binding]; other site
449447010369	active site pocket [active]
449447010370	cleavage site
449447010371	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
449447010372	DXD motif; other site
449447010373	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
449447010374	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
449447010375	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
449447010376	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
449447010377	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
449447010378	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447010379	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447010380	Probable transposase; Region: OrfB_IS605; pfam01385
449447010381	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447010382	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447010383	Probable transposase; Region: OrfB_IS605; pfam01385
449447010384	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447010385	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
449447010386	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447010387	active site
449447010388	ATP binding site [chemical binding]; other site
449447010389	substrate binding site [chemical binding]; other site
449447010390	activation loop (A-loop); other site
449447010391	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
449447010392	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447010393	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447010394	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
449447010395	Fatty acid desaturase; Region: FA_desaturase; pfam00487
449447010396	putative di-iron ligands [ion binding]; other site
449447010397	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
449447010398	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
449447010399	Tetratricopeptide repeat; Region: TPR_16; pfam13432
449447010400	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
449447010401	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
449447010402	Walker A/P-loop; other site
449447010403	ATP binding site [chemical binding]; other site
449447010404	Q-loop/lid; other site
449447010405	ABC transporter signature motif; other site
449447010406	Walker B; other site
449447010407	D-loop; other site
449447010408	H-loop/switch region; other site
449447010409	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
449447010410	calcium/proton exchanger (cax); Region: cax; TIGR00378
449447010411	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
449447010412	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
449447010413	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
449447010414	putative active site [active]
449447010415	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
449447010416	active site
449447010417	putative substrate binding region [chemical binding]; other site
449447010418	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
449447010419	thiamine monophosphate kinase; Provisional; Region: PRK05731
449447010420	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
449447010421	ATP binding site [chemical binding]; other site
449447010422	dimerization interface [polypeptide binding]; other site
449447010423	signal recognition particle protein; Provisional; Region: PRK10867
449447010424	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
449447010425	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
449447010426	P loop; other site
449447010427	GTP binding site [chemical binding]; other site
449447010428	Signal peptide binding domain; Region: SRP_SPB; pfam02978
449447010429	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
449447010430	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
449447010431	dimerization interface [polypeptide binding]; other site
449447010432	domain crossover interface; other site
449447010433	redox-dependent activation switch; other site
449447010434	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447010435	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
449447010436	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447010437	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447010438	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447010439	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
449447010440	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
449447010441	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
449447010442	Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403
449447010443	Protein of unknown function (DUF3082); Region: DUF3082; pfam11282
449447010444	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
449447010445	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
449447010446	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
449447010447	cofactor binding site; other site
449447010448	DNA binding site [nucleotide binding]
449447010449	substrate interaction site [chemical binding]; other site
449447010450	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447010451	Helix-turn-helix domains; Region: HTH; cl00088
449447010452	Integrase core domain; Region: rve; cl01316
449447010453	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
449447010454	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
449447010455	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
449447010456	P-loop; other site
449447010457	Magnesium ion binding site [ion binding]; other site
449447010458	photochlorophyllide reductase subunit B; Region: chlB; CHL00076
449447010459	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
449447010460	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
449447010461	Uncharacterized conserved protein [Function unknown]; Region: COG1565
449447010462	Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636
449447010463	lipoyl synthase; Provisional; Region: PRK12928
449447010464	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447010465	FeS/SAM binding site; other site
449447010466	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
449447010467	Mechanosensitive ion channel; Region: MS_channel; pfam00924
449447010468	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
449447010469	putative GSH binding site [chemical binding]; other site
449447010470	catalytic residues [active]
449447010471	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948
449447010472	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447010473	Walker A motif; other site
449447010474	ATP binding site [chemical binding]; other site
449447010475	Walker B motif; other site
449447010476	arginine finger; other site
449447010477	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
449447010478	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
449447010479	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
449447010480	[4Fe-4S] binding site [ion binding]; other site
449447010481	molybdopterin cofactor binding site; other site
449447010482	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
449447010483	molybdopterin cofactor binding site; other site
449447010484	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
449447010485	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
449447010486	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
449447010487	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
449447010488	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
449447010489	Photosystem II 10 kDa phosphoprotein; Region: PsbH; cl02951
449447010490	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
449447010491	glycogen branching enzyme; Provisional; Region: PRK05402
449447010492	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
449447010493	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
449447010494	active site
449447010495	catalytic site [active]
449447010496	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706
449447010497	Fasciclin domain; Region: Fasciclin; cl02663
449447010498	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
449447010499	Tubulin like; Region: Tubulin_2; pfam13809
449447010500	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
449447010501	ornithine carbamoyltransferase; Provisional; Region: PRK00779
449447010502	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
449447010503	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447010504	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
449447010505	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447010506	Transposase domain (DUF772); Region: DUF772; cl15789
449447010507	Protein of unknown function (DUF433); Region: DUF433; cl01030
449447010508	alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392
449447010509	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
449447010510	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
449447010511	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
449447010512	molybdopterin cofactor binding site; other site
449447010513	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
449447010514	molybdopterin cofactor binding site; other site
449447010515	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447010516	Transposase domain (DUF772); Region: DUF772; cl15789
449447010517	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447010518	Transposase domain (DUF772); Region: DUF772; cl15789
449447010519	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
449447010520	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
449447010521	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
449447010522	motif II; other site
449447010523	bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477
449447010524	Pantoate-beta-alanine ligase; Region: PanC; cd00560
449447010525	active site
449447010526	ATP-binding site [chemical binding]; other site
449447010527	pantoate-binding site; other site
449447010528	HXXH motif; other site
449447010529	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
449447010530	CMP-binding site; other site
449447010531	The sites determining sugar specificity; other site
449447010532	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
449447010533	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
449447010534	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863
449447010535	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
449447010536	Psb28 protein; Region: Psb28; cl04326
449447010537	Protein of unknown function (DUF3344); Region: DUF3344; pfam11824
449447010538	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
449447010539	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447010540	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
449447010541	2-isopropylmalate synthase; Validated; Region: PRK00915
449447010542	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
449447010543	active site
449447010544	catalytic residues [active]
449447010545	metal binding site [ion binding]; metal-binding site
449447010546	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
449447010547	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
449447010548	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
449447010549	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
449447010550	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
449447010551	DNA binding residues [nucleotide binding]
449447010552	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
449447010553	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
449447010554	active site
449447010555	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
449447010556	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
449447010557	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
449447010558	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
449447010559	RPB1 interaction site [polypeptide binding]; other site
449447010560	RPB10 interaction site [polypeptide binding]; other site
449447010561	RPB11 interaction site [polypeptide binding]; other site
449447010562	RPB3 interaction site [polypeptide binding]; other site
449447010563	RPB12 interaction site [polypeptide binding]; other site
449447010564	DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597
449447010565	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
449447010566	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
449447010567	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
449447010568	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
449447010569	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
449447010570	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
449447010571	DNA binding site [nucleotide binding]
449447010572	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
449447010573	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
449447010574	Coenzyme A binding pocket [chemical binding]; other site
449447010575	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
449447010576	PPIC-type PPIASE domain; Region: Rotamase; cl08278
449447010577	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
449447010578	ligand binding site [chemical binding]; other site
449447010579	flexible hinge region; other site
449447010580	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
449447010581	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cd02259
449447010582	putative active site [active]
449447010583	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
449447010584	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
449447010585	Walker A/P-loop; other site
449447010586	ATP binding site [chemical binding]; other site
449447010587	Q-loop/lid; other site
449447010588	ABC transporter signature motif; other site
449447010589	Walker B; other site
449447010590	D-loop; other site
449447010591	H-loop/switch region; other site
449447010592	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
449447010593	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
449447010594	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
449447010595	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
449447010596	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
449447010597	catalytic residues [active]
449447010598	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
449447010599	DNA binding residues [nucleotide binding]
449447010600	dimerization interface [polypeptide binding]; other site
449447010601	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
449447010602	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
449447010603	Helix-turn-helix domains; Region: HTH; cl00088
449447010604	Helix-turn-helix domains; Region: HTH; cl00088
449447010605	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447010606	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447010607	Probable transposase; Region: OrfB_IS605; pfam01385
449447010608	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447010609	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
449447010610	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_5; cd11352
449447010611	active site
449447010612	catalytic site [active]
449447010613	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
449447010614	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
449447010615	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
449447010616	CHAT domain; Region: CHAT; pfam12770
449447010617	FOG: WD40 repeat [General function prediction only]; Region: COG2319
449447010618	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
449447010619	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447010620	structural tetrad; other site
449447010621	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447010622	structural tetrad; other site
449447010623	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
449447010624	The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes.  But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736
449447010625	N-acetyl-D-glucosamine binding site [chemical binding]; other site
449447010626	catalytic residue [active]
449447010627	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447010628	putative active site [active]
449447010629	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
449447010630	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
449447010631	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
449447010632	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
449447010633	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447010634	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447010635	Probable transposase; Region: OrfB_IS605; pfam01385
449447010636	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447010637	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773
449447010638	Protein of unknown function, DUF393; Region: DUF393; cl01136
449447010639	Protein of unknown function (DUF760); Region: DUF760; pfam05542
449447010640	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
449447010641	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
449447010642	active site
449447010643	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
449447010644	PspA/IM30 family; Region: PspA_IM30; pfam04012
449447010645	18S rRNA biogenesis protein RCL1; Region: 18S_RNA_Rcl1p; TIGR03400
449447010646	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447010647	Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372
449447010648	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447010649	structural tetrad; other site
449447010650	FOG: WD40 repeat [General function prediction only]; Region: COG2319
449447010651	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447010652	structural tetrad; other site
449447010653	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
449447010654	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
449447010655	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447010656	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
449447010657	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447010658	Helix-turn-helix domains; Region: HTH; cl00088
449447010659	Helix-turn-helix domains; Region: HTH; cl00088
449447010660	Integrase core domain; Region: rve; cl01316
449447010661	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447010662	CHAT domain; Region: CHAT; pfam12770
449447010663	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
449447010664	CHAT domain; Region: CHAT; pfam12770
449447010665	Integrase core domain; Region: rve; cl01316
449447010666	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447010667	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447010668	Helix-turn-helix domains; Region: HTH; cl00088
449447010669	Integrase core domain; Region: rve; cl01316
449447010670	Helix-turn-helix domains; Region: HTH; cl00088
449447010671	DNA binding site [nucleotide binding]
449447010672	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447010673	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447010674	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
449447010675	Fic/DOC family; Region: Fic; cl00960
449447010676	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
449447010677	Protein of unknown function (DUF2283); Region: DUF2283; cl02251
449447010678	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
449447010679	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447010680	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447010681	PUCC protein; Region: PUCC; pfam03209
449447010682	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
449447010683	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
449447010684	active site
449447010685	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
449447010686	Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; cl09869
449447010687	arogenate dehydrogenase; Reviewed; Region: PRK07417
449447010688	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447010689	Cupin domain; Region: Cupin_2; cl09118
449447010690	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
449447010691	putative hydrophobic ligand binding site [chemical binding]; other site
449447010692	Probable transposase; Region: OrfB_IS605; pfam01385
449447010693	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447010694	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447010695	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
449447010696	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
449447010697	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
449447010698	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
449447010699	active site
449447010700	Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602
449447010701	14-3-3 domain; Region: 14-3-3; cl02098
449447010702	dimer interface [polypeptide binding]; other site
449447010703	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
449447010704	Hexamer interface [polypeptide binding]; other site
449447010705	Hexagonal pore residue; other site
449447010706	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
449447010707	Hexamer interface [polypeptide binding]; other site
449447010708	Hexagonal pore residue; other site
449447010709	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
449447010710	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
449447010711	oligomerization interface [polypeptide binding]; other site
449447010712	active site
449447010713	metal binding site [ion binding]; metal-binding site
449447010714	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
449447010715	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447010716	S-adenosylmethionine binding site [chemical binding]; other site
449447010717	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447010718	pyruvate kinase; Region: pyruv_kin; TIGR01064
449447010719	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
449447010720	domain interfaces; other site
449447010721	active site
449447010722	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
449447010723	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
449447010724	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447010725	Integrase core domain; Region: rve; cl01316
449447010726	Helix-turn-helix domains; Region: HTH; cl00088
449447010727	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447010728	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447010729	conserved gate region; other site
449447010730	dimer interface [polypeptide binding]; other site
449447010731	putative PBP binding loops; other site
449447010732	ABC-ATPase subunit interface; other site
449447010733	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447010734	Walker A/P-loop; other site
449447010735	ATP binding site [chemical binding]; other site
449447010736	ABC transporter; Region: ABC_tran; pfam00005
449447010737	Q-loop/lid; other site
449447010738	ABC transporter signature motif; other site
449447010739	Walker B; other site
449447010740	D-loop; other site
449447010741	H-loop/switch region; other site
449447010742	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
449447010743	AMIN domain; Region: AMIN; pfam11741
449447010744	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
449447010745	active site
449447010746	metal binding site [ion binding]; metal-binding site
449447010747	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
449447010748	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447010749	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447010750	Helix-turn-helix domains; Region: HTH; cl00088
449447010751	Helix-turn-helix domains; Region: HTH; cl00088
449447010752	Integrase core domain; Region: rve; cl01316
449447010753	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447010754	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
449447010755	WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915
449447010756	Substrate binding site; other site
449447010757	Mg++ binding site; other site
449447010758	metal-binding site
449447010759	Mg++ binding site; other site
449447010760	metal-binding site
449447010761	Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605
449447010762	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
449447010763	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
449447010764	dimer interface [polypeptide binding]; other site
449447010765	active site
449447010766	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
449447010767	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
449447010768	active site
449447010769	motif I; other site
449447010770	motif II; other site
449447010771	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
449447010772	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
449447010773	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447010774	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
449447010775	YcfA-like protein; Region: YcfA; cl00752
449447010776	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
449447010777	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447010778	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
449447010779	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
449447010780	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
449447010781	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
449447010782	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
449447010783	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
449447010784	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447010785	active site
449447010786	ATP binding site [chemical binding]; other site
449447010787	substrate binding site [chemical binding]; other site
449447010788	activation loop (A-loop); other site
449447010789	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
449447010790	AAA domain; Region: AAA_13; pfam13166
449447010791	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447010792	Walker A motif; other site
449447010793	ATP binding site [chemical binding]; other site
449447010794	Flagellin N-methylase; Region: FliB; cl00497
449447010795	Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; cl01017
449447010796	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
449447010797	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
449447010798	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447010799	Protein of unknown function (DUF552); Region: DUF552; cl00775
449447010800	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
449447010801	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
449447010802	catalytic residue [active]
449447010803	Protein of unknown function (DUF3539); Region: DUF3539; pfam12058
449447010804	NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504
449447010805	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
449447010806	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
449447010807	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447010808	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
449447010809	GTP-binding protein YchF; Reviewed; Region: PRK09601
449447010810	YchF GTPase; Region: YchF; cd01900
449447010811	G1 box; other site
449447010812	GTP/Mg2+ binding site [chemical binding]; other site
449447010813	Switch I region; other site
449447010814	G2 box; other site
449447010815	Switch II region; other site
449447010816	G3 box; other site
449447010817	G4 box; other site
449447010818	G5 box; other site
449447010819	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
449447010820	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
449447010821	elongation factor G; Reviewed; Region: PRK12740
449447010822	G1 box; other site
449447010823	putative GEF interaction site [polypeptide binding]; other site
449447010824	GTP/Mg2+ binding site [chemical binding]; other site
449447010825	Switch I region; other site
449447010826	G2 box; other site
449447010827	G3 box; other site
449447010828	Switch II region; other site
449447010829	G4 box; other site
449447010830	G5 box; other site
449447010831	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
449447010832	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
449447010833	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
449447010834	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
449447010835	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
449447010836	XisI protein; Region: XisI; pfam08869
449447010837	XisH protein; Region: XisH; pfam08814
449447010838	Protein of unknown function (DUF433); Region: DUF433; cl01030
449447010839	Protein of unknown function (DUF2283); Region: DUF2283; cl02251
449447010840	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
449447010841	Domain of unknown function (DUF1902); Region: DUF1902; pfam08972
449447010842	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
449447010843	putative active site [active]
449447010844	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
449447010845	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
449447010846	Protein of unknown function (DUF2283); Region: DUF2283; cl02251
449447010847	XisI protein; Region: XisI; pfam08869
449447010848	TIR domain; Region: TIR_2; cl15770
449447010849	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447010850	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
449447010851	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447010852	binding surface
449447010853	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447010854	TPR motif; other site
449447010855	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447010856	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447010857	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447010858	binding surface
449447010859	TPR motif; other site
449447010860	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447010861	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447010862	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447010863	binding surface
449447010864	TPR motif; other site
449447010865	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447010866	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945
449447010867	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447010868	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
449447010869	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
449447010870	Cytochrome c; Region: Cytochrom_C; cl11414
449447010871	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
449447010872	Cupin domain; Region: Cupin_2; cl09118
449447010873	Cupin domain; Region: Cupin_2; cl09118
449447010874	Transposase domain (DUF772); Region: DUF772; cl15789
449447010875	Transposase domain (DUF772); Region: DUF772; cl15789
449447010876	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
449447010877	catalytic triad [active]
449447010878	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
449447010879	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
449447010880	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
449447010881	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
449447010882	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
449447010883	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
449447010884	protein binding site [polypeptide binding]; other site
449447010885	Protein of unknown function DUF262; Region: DUF262; cl14890
449447010886	Protein of unknown function DUF262; Region: DUF262; cl14890
449447010887	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
449447010888	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
449447010889	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
449447010890	NADH dehydrogenase subunit 6; Region: ndhG; CHL00016
449447010891	NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634
449447010892	NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403
449447010893	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
449447010894	NADH dehydrogenase; Region: NADHdh; cl00469
449447010895	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
449447010896	active site
449447010897	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
449447010898	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
449447010899	Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome.  The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223
449447010900	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
449447010901	trimer interface [polypeptide binding]; other site
449447010902	active site
449447010903	substrate binding site [chemical binding]; other site
449447010904	CoA binding site [chemical binding]; other site
449447010905	Condensation domain; Region: Condensation; pfam00668
449447010906	L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443
449447010907	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
449447010908	AMP-binding enzyme; Region: AMP-binding; cl15778
449447010909	Phosphopantetheine attachment site; Region: PP-binding; cl09936
449447010910	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
449447010911	putative NAD(P) binding site [chemical binding]; other site
449447010912	active site
449447010913	putative substrate binding site [chemical binding]; other site
449447010914	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447010915	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
449447010916	NAD(P) binding site [chemical binding]; other site
449447010917	active site
449447010918	Condensation domain; Region: Condensation; pfam00668
449447010919	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
449447010920	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
449447010921	AMP-binding enzyme; Region: AMP-binding; cl15778
449447010922	AMP-binding enzyme; Region: AMP-binding; cl15778
449447010923	Phosphopantetheine attachment site; Region: PP-binding; cl09936
449447010924	Putative capsular polysaccharide synthesis protein; Region: NKWYS; pfam10364
449447010925	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
449447010926	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
449447010927	putative NAD(P) binding site [chemical binding]; other site
449447010928	putative active site [active]
449447010929	Cupin domain; Region: Cupin_2; cl09118
449447010930	Prephenate dehydratase; Region: PDT; pfam00800
449447010931	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
449447010932	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
449447010933	homotetramer interface [polypeptide binding]; other site
449447010934	FMN binding site [chemical binding]; other site
449447010935	homodimer contacts [polypeptide binding]; other site
449447010936	putative active site [active]
449447010937	putative substrate binding site [chemical binding]; other site
449447010938	peptide synthase; Provisional; Region: PRK12316
449447010939	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
449447010940	AMP-binding enzyme; Region: AMP-binding; cl15778
449447010941	AMP-binding enzyme; Region: AMP-binding; cl15778
449447010942	Phosphopantetheine attachment site; Region: PP-binding; cl09936
449447010943	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
449447010944	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
449447010945	AMP-binding enzyme; Region: AMP-binding; cl15778
449447010946	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
449447010947	putative NADP binding site [chemical binding]; other site
449447010948	active site
449447010949	peptide synthase; Validated; Region: PRK05691
449447010950	Phosphopantetheine attachment site; Region: PP-binding; cl09936
449447010951	SWIM zinc finger; Region: SWIM; cl15408
449447010952	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447010953	Helix-turn-helix domains; Region: HTH; cl00088
449447010954	Integrase core domain; Region: rve; cl01316
449447010955	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
449447010956	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
449447010957	active site
449447010958	interdomain interaction site; other site
449447010959	putative metal-binding site [ion binding]; other site
449447010960	nucleotide binding site [chemical binding]; other site
449447010961	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
449447010962	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
449447010963	domain II; other site
449447010964	domain III; other site
449447010965	nucleotide binding site [chemical binding]; other site
449447010966	DNA binding groove [nucleotide binding]
449447010967	catalytic site [active]
449447010968	domain IV; other site
449447010969	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
449447010970	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
449447010971	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
449447010972	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447010973	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
449447010974	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
449447010975	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447010976	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447010977	Probable transposase; Region: OrfB_IS605; pfam01385
449447010978	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447010979	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447010980	binding surface
449447010981	TPR motif; other site
449447010982	TPR repeat; Region: TPR_11; pfam13414
449447010983	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447010984	binding surface
449447010985	TPR repeat; Region: TPR_11; pfam13414
449447010986	TPR motif; other site
449447010987	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447010988	TPR motif; other site
449447010989	binding surface
449447010990	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
449447010991	Creatinine amidohydrolase; Region: Creatininase; cl00618
449447010992	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
449447010993	active site
449447010994	multimer interface [polypeptide binding]; other site
449447010995	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731
449447010996	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
449447010997	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
449447010998	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
449447010999	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447011000	FeS/SAM binding site; other site
449447011001	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
449447011002	CpeS-like protein; Region: CpeS; pfam09367
449447011003	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
449447011004	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447011005	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
449447011006	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447011007	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447011008	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447011009	succinyldiaminopimelate transaminase; Validated; Region: PRK07366
449447011010	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
449447011011	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447011012	homodimer interface [polypeptide binding]; other site
449447011013	catalytic residue [active]
449447011014	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
449447011015	catalytic residues [active]
449447011016	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
449447011017	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447011018	putative PBP binding loops; other site
449447011019	dimer interface [polypeptide binding]; other site
449447011020	ABC-ATPase subunit interface; other site
449447011021	NaMN:DMB phosphoribosyltransferase [Coenzyme metabolism]; Region: CobT; COG2038
449447011022	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
449447011023	putative dimer interface [polypeptide binding]; other site
449447011024	active site pocket [active]
449447011025	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
449447011026	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
449447011027	putative NAD(P) binding site [chemical binding]; other site
449447011028	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
449447011029	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
449447011030	carboxyltransferase (CT) interaction site; other site
449447011031	biotinylation site [posttranslational modification]; other site
449447011032	elongation factor P; Validated; Region: PRK00529
449447011033	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
449447011034	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
449447011035	RNA binding site [nucleotide binding]; other site
449447011036	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
449447011037	RNA binding site [nucleotide binding]; other site
449447011038	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
449447011039	HsdM N-terminal domain; Region: HsdM_N; pfam12161
449447011040	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447011041	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
449447011042	active site
449447011043	NTP binding site [chemical binding]; other site
449447011044	metal binding triad [ion binding]; metal-binding site
449447011045	antibiotic binding site [chemical binding]; other site
449447011046	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
449447011047	active site
449447011048	NTP binding site [chemical binding]; other site
449447011049	metal binding triad [ion binding]; metal-binding site
449447011050	antibiotic binding site [chemical binding]; other site
449447011051	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
449447011052	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
449447011053	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
449447011054	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
449447011055	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
449447011056	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
449447011057	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
449447011058	ATP binding site [chemical binding]; other site
449447011059	putative Mg++ binding site [ion binding]; other site
449447011060	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447011061	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447011062	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447011063	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447011064	Transposase domain (DUF772); Region: DUF772; cl15789
449447011065	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447011066	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447011067	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447011068	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447011069	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447011070	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447011071	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447011072	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
449447011073	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
449447011074	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
449447011075	putative lipid kinase; Reviewed; Region: PRK13057
449447011076	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
449447011077	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
449447011078	substrate binding pocket [chemical binding]; other site
449447011079	membrane-bound complex binding site; other site
449447011080	hinge residues; other site
449447011081	Integral membrane protein DUF92; Region: DUF92; cl00793
449447011082	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
449447011083	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
449447011084	catalytic loop [active]
449447011085	iron binding site [ion binding]; other site
449447011086	cobyric acid synthase; Provisional; Region: PRK00784
449447011087	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447011088	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447011089	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
449447011090	catalytic triad [active]
449447011091	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
449447011092	dimer interface [polypeptide binding]; other site
449447011093	[2Fe-2S] cluster binding site [ion binding]; other site
449447011094	response regulator FixJ; Provisional; Region: fixJ; PRK09390
449447011095	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447011096	active site
449447011097	phosphorylation site [posttranslational modification]
449447011098	intermolecular recognition site; other site
449447011099	dimerization interface [polypeptide binding]; other site
449447011100	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
449447011101	DNA binding residues [nucleotide binding]
449447011102	dimerization interface [polypeptide binding]; other site
449447011103	Protein of unknown function (DUF1622); Region: DUF1622; cl01991
449447011104	Clp protease; Region: CLP_protease; pfam00574
449447011105	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
449447011106	oligomer interface [polypeptide binding]; other site
449447011107	active site residues [active]
449447011108	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
449447011109	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
449447011110	oligomer interface [polypeptide binding]; other site
449447011111	active site residues [active]
449447011112	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
449447011113	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447011114	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
449447011115	adenylate kinase; Provisional; Region: adk; PRK02496
449447011116	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
449447011117	AMP-binding site [chemical binding]; other site
449447011118	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
449447011119	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
449447011120	SecY translocase; Region: SecY; pfam00344
449447011121	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
449447011122	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
449447011123	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
449447011124	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
449447011125	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
449447011126	23S rRNA interface [nucleotide binding]; other site
449447011127	5S rRNA interface [nucleotide binding]; other site
449447011128	L27 interface [polypeptide binding]; other site
449447011129	L5 interface [polypeptide binding]; other site
449447011130	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
449447011131	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
449447011132	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
449447011133	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
449447011134	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
449447011135	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
449447011136	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
449447011137	KOW motif; Region: KOW; cl00354
449447011138	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
449447011139	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
449447011140	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
449447011141	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
449447011142	23S rRNA interface [nucleotide binding]; other site
449447011143	putative translocon interaction site; other site
449447011144	signal recognition particle (SRP54) interaction site; other site
449447011145	L23 interface [polypeptide binding]; other site
449447011146	trigger factor interaction site; other site
449447011147	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
449447011148	23S rRNA interface [nucleotide binding]; other site
449447011149	5S rRNA interface [nucleotide binding]; other site
449447011150	putative antibiotic binding site [chemical binding]; other site
449447011151	L25 interface [polypeptide binding]; other site
449447011152	L27 interface [polypeptide binding]; other site
449447011153	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
449447011154	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
449447011155	G-X-X-G motif; other site
449447011156	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
449447011157	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
449447011158	putative translocon binding site; other site
449447011159	protein-rRNA interface [nucleotide binding]; other site
449447011160	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
449447011161	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
449447011162	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
449447011163	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
449447011164	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
449447011165	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
449447011166	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
449447011167	Nitrogen regulatory protein P-II; Region: P-II; cl00412
449447011168	Nitrogen regulatory protein P-II; Region: P-II; smart00938
449447011169	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
449447011170	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
449447011171	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
449447011172	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
449447011173	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
449447011174	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
449447011175	metal binding site 2 [ion binding]; metal-binding site
449447011176	putative DNA binding helix; other site
449447011177	metal binding site 1 [ion binding]; metal-binding site
449447011178	dimer interface [polypeptide binding]; other site
449447011179	structural Zn2+ binding site [ion binding]; other site
449447011180	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789
449447011181	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
449447011182	putative active site [active]
449447011183	catalytic triad [active]
449447011184	Cation efflux family; Region: Cation_efflux; cl00316
449447011185	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
449447011186	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
449447011187	NAD binding site [chemical binding]; other site
449447011188	substrate binding site [chemical binding]; other site
449447011189	homodimer interface [polypeptide binding]; other site
449447011190	active site
449447011191	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
449447011192	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
449447011193	GTPase CgtA; Reviewed; Region: obgE; PRK12299
449447011194	GTP1/OBG; Region: GTP1_OBG; pfam01018
449447011195	Obg GTPase; Region: Obg; cd01898
449447011196	G1 box; other site
449447011197	GTP/Mg2+ binding site [chemical binding]; other site
449447011198	Switch I region; other site
449447011199	G2 box; other site
449447011200	G3 box; other site
449447011201	Switch II region; other site
449447011202	G4 box; other site
449447011203	G5 box; other site
449447011204	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
449447011205	HEPN domain; Region: HEPN; cl00824
449447011206	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
449447011207	active site
449447011208	NTP binding site [chemical binding]; other site
449447011209	metal binding triad [ion binding]; metal-binding site
449447011210	antibiotic binding site [chemical binding]; other site
449447011211	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
449447011212	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
449447011213	NB-ARC domain; Region: NB-ARC; pfam00931
449447011214	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447011215	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
449447011216	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
449447011217	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
449447011218	ScpA/B protein; Region: ScpA_ScpB; cl00598
449447011219	ScpA/B protein; Region: ScpA_ScpB; cl00598
449447011220	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
449447011221	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
449447011222	Domain of unknown function DUF21; Region: DUF21; pfam01595
449447011223	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
449447011224	Transporter associated domain; Region: CorC_HlyC; cl08393
449447011225	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447011226	CemA family; Region: CemA; cl03855
449447011227	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
449447011228	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
449447011229	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447011230	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
449447011231	hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418
449447011232	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
449447011233	dimerization interface [polypeptide binding]; other site
449447011234	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
449447011235	ATP binding site [chemical binding]; other site
449447011236	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447011237	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447011238	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
449447011239	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
449447011240	ATP binding site [chemical binding]; other site
449447011241	putative Mg++ binding site [ion binding]; other site
449447011242	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
449447011243	nucleotide binding region [chemical binding]; other site
449447011244	ATP-binding site [chemical binding]; other site
449447011245	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
449447011246	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782
449447011247	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
449447011248	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
449447011249	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
449447011250	4Fe-4S binding domain; Region: Fer4; cl02805
449447011251	hybrid cluster protein; Provisional; Region: PRK05290
449447011252	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
449447011253	ACS interaction site; other site
449447011254	CODH interaction site; other site
449447011255	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
449447011256	ACS interaction site; other site
449447011257	CODH interaction site; other site
449447011258	metal cluster binding site [ion binding]; other site
449447011259	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
449447011260	putative active site [active]
449447011261	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
449447011262	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
449447011263	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447011264	TPR repeat; Region: TPR_11; pfam13414
449447011265	binding surface
449447011266	TPR motif; other site
449447011267	TPR repeat; Region: TPR_11; pfam13414
449447011268	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447011269	binding surface
449447011270	TPR motif; other site
449447011271	TPR repeat; Region: TPR_11; pfam13414
449447011272	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447011273	binding surface
449447011274	TPR motif; other site
449447011275	TPR repeat; Region: TPR_11; pfam13414
449447011276	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447011277	binding surface
449447011278	TPR repeat; Region: TPR_11; pfam13414
449447011279	TPR motif; other site
449447011280	TPR repeat; Region: TPR_11; pfam13414
449447011281	TPR repeat; Region: TPR_11; pfam13414
449447011282	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447011283	binding surface
449447011284	TPR repeat; Region: TPR_11; pfam13414
449447011285	TPR motif; other site
449447011286	TPR repeat; Region: TPR_11; pfam13414
449447011287	TPR repeat; Region: TPR_11; pfam13414
449447011288	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447011289	binding surface
449447011290	TPR motif; other site
449447011291	TPR repeat; Region: TPR_11; pfam13414
449447011292	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447011293	binding surface
449447011294	TPR repeat; Region: TPR_11; pfam13414
449447011295	TPR motif; other site
449447011296	TPR repeat; Region: TPR_11; pfam13414
449447011297	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447011298	binding surface
449447011299	TPR motif; other site
449447011300	TPR repeat; Region: TPR_11; pfam13414
449447011301	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447011302	Walker A motif; other site
449447011303	ATP binding site [chemical binding]; other site
449447011304	Walker B motif; other site
449447011305	arginine finger; other site
449447011306	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447011307	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447011308	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447011309	Transposase [DNA replication, recombination, and repair]; Region: COG5433
449447011310	yiaA/B two helix domain; Region: YiaAB; cl01759
449447011311	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
449447011312	protein I interface; other site
449447011313	D2 interface; other site
449447011314	protein T interface; other site
449447011315	chlorophyll binding site; other site
449447011316	beta carotene binding site; other site
449447011317	pheophytin binding site; other site
449447011318	manganese-stabilizing polypeptide interface; other site
449447011319	CP43 interface; other site
449447011320	protein L interface; other site
449447011321	oxygen evolving complex binding site; other site
449447011322	bromide binding site; other site
449447011323	quinone binding site; other site
449447011324	Fe binding site [ion binding]; other site
449447011325	core light harvesting interface; other site
449447011326	cytochrome b559 alpha subunit interface; other site
449447011327	cytochrome c-550 interface; other site
449447011328	protein J interface; other site
449447011329	PemK-like protein; Region: PemK; cl00995
449447011330	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
449447011331	Stage II sporulation protein; Region: SpoIID; pfam08486
449447011332	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
449447011333	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
449447011334	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
449447011335	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
449447011336	active site
449447011337	metal binding site [ion binding]; metal-binding site
449447011338	Uncharacterized conserved protein [Function unknown]; Region: COG2912
449447011339	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
449447011340	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
449447011341	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
449447011342	active site
449447011343	metal binding site [ion binding]; metal-binding site
449447011344	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
449447011345	active site
449447011346	dimer interface [polypeptide binding]; other site
449447011347	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
449447011348	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
449447011349	active site
449447011350	catalytic tetrad [active]
449447011351	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
449447011352	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
449447011353	GSH binding site [chemical binding]; other site
449447011354	catalytic residues [active]
449447011355	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
449447011356	nucleoside/Zn binding site; other site
449447011357	dimer interface [polypeptide binding]; other site
449447011358	catalytic motif [active]
449447011359	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
449447011360	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
449447011361	hypothetical protein; Provisional; Region: PLN03150
449447011362	Leucine-rich repeats, typical (most populated) subfamily; Region: LRR_TYP; cl15310
449447011363	GXWXG protein; Region: GXWXG; pfam14231
449447011364	Domain of unknown function (DUF4334); Region: DUF4334; pfam14232
449447011365	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
449447011366	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
449447011367	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
449447011368	catalytic residue [active]
449447011369	NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473
449447011370	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
449447011371	O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445
449447011372	AMP-binding enzyme; Region: AMP-binding; cl15778
449447011373	O-succinylbenzoate synthase; Provisional; Region: PRK02714
449447011374	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
449447011375	active site
449447011376	Helix-turn-helix domains; Region: HTH; cl00088
449447011377	Winged helix-turn helix; Region: HTH_29; pfam13551
449447011378	Winged helix-turn helix; Region: HTH_33; pfam13592
449447011379	Integrase core domain; Region: rve; cl01316
449447011380	Winged helix-turn helix; Region: HTH_29; pfam13551
449447011381	Helix-turn-helix domains; Region: HTH; cl00088
449447011382	Helix-turn-helix domains; Region: HTH; cl00088
449447011383	Integrase core domain; Region: rve; cl01316
449447011384	Calx-beta domain; Region: Calx-beta; cl02522
449447011385	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
449447011386	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
449447011387	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
449447011388	ARD/ARD' family; Region: ARD; pfam03079
449447011389	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
449447011390	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
449447011391	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
449447011392	putative active site [active]
449447011393	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
449447011394	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
449447011395	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
449447011396	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
449447011397	DXD motif; other site
449447011398	bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424
449447011399	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
449447011400	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447011401	NAD(P) binding site [chemical binding]; other site
449447011402	active site
449447011403	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
449447011404	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
449447011405	putative NAD(P) binding site [chemical binding]; other site
449447011406	Phosphopantetheine attachment site; Region: PP-binding; cl09936
449447011407	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
449447011408	Ligand Binding Site [chemical binding]; other site
449447011409	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
449447011410	Competence protein; Region: Competence; cl00471
449447011411	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
449447011412	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
449447011413	oligomer interface [polypeptide binding]; other site
449447011414	tandem repeat interface [polypeptide binding]; other site
449447011415	active site residues [active]
449447011416	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
449447011417	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
449447011418	tandem repeat interface [polypeptide binding]; other site
449447011419	oligomer interface [polypeptide binding]; other site
449447011420	active site residues [active]
449447011421	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
449447011422	cofactor binding site; other site
449447011423	DNA binding site [nucleotide binding]
449447011424	substrate interaction site [chemical binding]; other site
449447011425	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
449447011426	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447011427	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
449447011428	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
449447011429	G1 box; other site
449447011430	putative GEF interaction site [polypeptide binding]; other site
449447011431	GTP/Mg2+ binding site [chemical binding]; other site
449447011432	Switch I region; other site
449447011433	G2 box; other site
449447011434	G3 box; other site
449447011435	Switch II region; other site
449447011436	G4 box; other site
449447011437	G5 box; other site
449447011438	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
449447011439	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
449447011440	putative acyl-acceptor binding pocket; other site
449447011441	Predicted transcriptional regulators [Transcription]; Region: COG1725
449447011442	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
449447011443	DNA-binding site [nucleotide binding]; DNA binding site
449447011444	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
449447011445	Tubulin like; Region: Tubulin_2; pfam13809
449447011446	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
449447011447	phosphodiesterase; Provisional; Region: PRK12704
449447011448	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
449447011449	ligand binding site [chemical binding]; other site
449447011450	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447011451	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447011452	putative active site [active]
449447011453	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447011454	putative active site [active]
449447011455	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
449447011456	AMP-binding enzyme; Region: AMP-binding; cl15778
449447011457	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
449447011458	Protein of unknown function (DUF3370); Region: DUF3370; pfam11850
449447011459	Uncharacterized conserved protein [Function unknown]; Region: COG4278
449447011460	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
449447011461	Domain of unknown function (DUF814); Region: DUF814; pfam05670
449447011462	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
449447011463	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
449447011464	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447011465	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447011466	binding surface
449447011467	TPR motif; other site
449447011468	TPR repeat; Region: TPR_11; pfam13414
449447011469	TPR repeat; Region: TPR_11; pfam13414
449447011470	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447011471	binding surface
449447011472	TPR motif; other site
449447011473	TPR repeat; Region: TPR_11; pfam13414
449447011474	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447011475	binding surface
449447011476	Tetratricopeptide repeat; Region: TPR_16; pfam13432
449447011477	TPR motif; other site
449447011478	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
449447011479	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
449447011480	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
449447011481	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
449447011482	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447011483	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447011484	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
449447011485	Uncharacterized conserved protein [Function unknown]; Region: COG1432
449447011486	LabA_like proteins; Region: LabA; cd10911
449447011487	putative metal binding site [ion binding]; other site
449447011488	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
449447011489	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
449447011490	active site residue [active]
449447011491	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
449447011492	active site residue [active]
449447011493	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
449447011494	Response regulator receiver domain; Region: Response_reg; pfam00072
449447011495	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447011496	active site
449447011497	phosphorylation site [posttranslational modification]
449447011498	intermolecular recognition site; other site
449447011499	dimerization interface [polypeptide binding]; other site
449447011500	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
449447011501	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
449447011502	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
449447011503	anti sigma factor interaction site; other site
449447011504	regulatory phosphorylation site [posttranslational modification]; other site
449447011505	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
449447011506	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447011507	Probable transposase; Region: OrfB_IS605; pfam01385
449447011508	Probable transposase; Region: OrfB_IS605; pfam01385
449447011509	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447011510	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447011511	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
449447011512	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
449447011513	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
449447011514	Walker A/P-loop; other site
449447011515	ATP binding site [chemical binding]; other site
449447011516	Q-loop/lid; other site
449447011517	ABC transporter signature motif; other site
449447011518	Walker B; other site
449447011519	D-loop; other site
449447011520	H-loop/switch region; other site
449447011521	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447011522	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
449447011523	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
449447011524	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
449447011525	transmembrane helices; other site
449447011526	Protein of unknown function (DUF3172); Region: DUF3172; pfam11371
449447011527	Nitrogen regulatory protein P-II; Region: P-II; cl00412
449447011528	Domain of unknown function (DUF897); Region: DUF897; cl01312
449447011529	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
449447011530	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
449447011531	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447011532	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
449447011533	FOG: CBS domain [General function prediction only]; Region: COG0517
449447011534	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
449447011535	CP12 domain; Region: CP12; cl14670
449447011536	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
449447011537	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
449447011538	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
449447011539	polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132
449447011540	acetyl-CoA synthetase; Provisional; Region: PRK00174
449447011541	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
449447011542	AMP-binding enzyme; Region: AMP-binding; cl15778
449447011543	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
449447011544	photosystem I subunit VII; Region: psaC; CHL00065
449447011545	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
449447011546	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447011547	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447011548	Transposase [DNA replication, recombination, and repair]; Region: COG5433
449447011549	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447011550	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447011551	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447011552	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447011553	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447011554	putative active site [active]
449447011555	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447011556	ABC transporter signature motif; other site
449447011557	Walker B; other site
449447011558	D-loop; other site
449447011559	H-loop/switch region; other site
449447011560	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
449447011561	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
449447011562	putative active site [active]
449447011563	putative dimer interface [polypeptide binding]; other site
449447011564	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447011565	threonine synthase; Reviewed; Region: PRK06721
449447011566	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
449447011567	homodimer interface [polypeptide binding]; other site
449447011568	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447011569	catalytic residue [active]
449447011570	imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951
449447011571	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
449447011572	putative active site pocket [active]
449447011573	4-fold oligomerization interface [polypeptide binding]; other site
449447011574	metal binding residues [ion binding]; metal-binding site
449447011575	3-fold/trimer interface [polypeptide binding]; other site
449447011576	Gram-negative bacterial tonB protein; Region: TonB; cl10048
449447011577	light-harvesting complex chlorophyll-a/b protein of photosystem I (Lhca); Provisional; Region: PLN00100
449447011578	light-harvesting-like protein 3; Provisional; Region: PLN00014
449447011579	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
449447011580	diaminopimelate epimerase; Region: PLN02536
449447011581	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
449447011582	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
449447011583	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
449447011584	Ligand binding site; other site
449447011585	Putative Catalytic site; other site
449447011586	DXD motif; other site
449447011587	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447011588	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
449447011589	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
449447011590	active site
449447011591	Methyltransferase domain; Region: Methyltransf_31; pfam13847
449447011592	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447011593	S-adenosylmethionine binding site [chemical binding]; other site
449447011594	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
449447011595	active site
449447011596	Clp protease ATP binding subunit; Region: clpC; CHL00095
449447011597	Clp amino terminal domain; Region: Clp_N; pfam02861
449447011598	Clp amino terminal domain; Region: Clp_N; pfam02861
449447011599	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447011600	Walker A motif; other site
449447011601	ATP binding site [chemical binding]; other site
449447011602	Walker B motif; other site
449447011603	arginine finger; other site
449447011604	UvrB/uvrC motif; Region: UVR; pfam02151
449447011605	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447011606	Walker A motif; other site
449447011607	ATP binding site [chemical binding]; other site
449447011608	Walker B motif; other site
449447011609	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
449447011610	Domain of unknown function (DUF4415); Region: DUF4415; cl01401
449447011611	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447011612	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
449447011613	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
449447011614	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
449447011615	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
449447011616	E3 interaction surface; other site
449447011617	lipoyl attachment site [posttranslational modification]; other site
449447011618	e3 binding domain; Region: E3_binding; pfam02817
449447011619	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
449447011620	Protein of unknown function (DUF561); Region: DUF561; pfam04481
449447011621	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360
449447011622	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
449447011623	Substrate binding site; other site
449447011624	Mg++ binding site; other site
449447011625	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
449447011626	active site
449447011627	substrate binding site [chemical binding]; other site
449447011628	CoA binding site [chemical binding]; other site
449447011629	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
449447011630	putative catalytic residue [active]
449447011631	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
449447011632	D-xylulose kinase; Region: XylB; TIGR01312
449447011633	N- and C-terminal domain interface [polypeptide binding]; other site
449447011634	active site
449447011635	MgATP binding site [chemical binding]; other site
449447011636	catalytic site [active]
449447011637	metal binding site [ion binding]; metal-binding site
449447011638	carbohydrate binding site [chemical binding]; other site
449447011639	Tocopherol cyclase; Region: Tocopherol_cycl; cl14571
449447011640	DsrE/DsrF-like family; Region: DrsE; cl00672
449447011641	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447011642	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447011643	Probable transposase; Region: OrfB_IS605; pfam01385
449447011644	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447011645	Potassium-transporting ATPase A subunit; Region: KdpA; cl00903
449447011646	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
449447011647	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
449447011648	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
449447011649	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
449447011650	cofactor binding site; other site
449447011651	DNA binding site [nucleotide binding]
449447011652	substrate interaction site [chemical binding]; other site
449447011653	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
449447011654	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447011655	Helix-turn-helix domains; Region: HTH; cl00088
449447011656	Integrase core domain; Region: rve; cl01316
449447011657	K+-transporting ATPase, c chain; Region: KdpC; cl00944
449447011658	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
449447011659	putative active site [active]
449447011660	DNA Topoisomerase IV; Region: TOP4c; smart00434
449447011661	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
449447011662	CAP-like domain; other site
449447011663	active site
449447011664	primary dimer interface [polypeptide binding]; other site
449447011665	Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188
449447011666	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
449447011667	Response regulator receiver domain; Region: Response_reg; pfam00072
449447011668	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447011669	active site
449447011670	phosphorylation site [posttranslational modification]
449447011671	intermolecular recognition site; other site
449447011672	dimerization interface [polypeptide binding]; other site
449447011673	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
449447011674	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
449447011675	Active Sites [active]
449447011676	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440
449447011677	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
449447011678	classical (c) SDRs; Region: SDR_c; cd05233
449447011679	short chain dehydrogenase; Provisional; Region: PRK07041
449447011680	NAD(P) binding site [chemical binding]; other site
449447011681	active site
449447011682	Methyltransferase domain; Region: Methyltransf_31; pfam13847
449447011683	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447011684	S-adenosylmethionine binding site [chemical binding]; other site
449447011685	peptide synthase; Provisional; Region: PRK12467
449447011686	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
449447011687	AMP-binding enzyme; Region: AMP-binding; cl15778
449447011688	Phosphopantetheine attachment site; Region: PP-binding; cl09936
449447011689	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
449447011690	peptide synthase; Provisional; Region: PRK12467
449447011691	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
449447011692	AMP-binding enzyme; Region: AMP-binding; cl15778
449447011693	Phosphopantetheine attachment site; Region: PP-binding; cl09936
449447011694	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
449447011695	AMP-binding enzyme; Region: AMP-binding; cl15778
449447011696	Phosphopantetheine attachment site; Region: PP-binding; cl09936
449447011697	peptide synthase; Provisional; Region: PRK12316
449447011698	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
449447011699	AMP-binding enzyme; Region: AMP-binding; cl15778
449447011700	AMP-binding enzyme; Region: AMP-binding; cl15778
449447011701	Phosphopantetheine attachment site; Region: PP-binding; cl09936
449447011702	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
449447011703	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
449447011704	AMP-binding enzyme; Region: AMP-binding; cl15778
449447011705	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447011706	S-adenosylmethionine binding site [chemical binding]; other site
449447011707	peptide synthase; Provisional; Region: PRK12467
449447011708	Phosphopantetheine attachment site; Region: PP-binding; cl09936
449447011709	Condensation domain; Region: Condensation; pfam00668
449447011710	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
449447011711	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
449447011712	AMP-binding enzyme; Region: AMP-binding; cl15778
449447011713	AMP-binding enzyme; Region: AMP-binding; cl15778
449447011714	Phosphopantetheine attachment site; Region: PP-binding; cl09936
449447011715	Condensation domain; Region: Condensation; pfam00668
449447011716	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
449447011717	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
449447011718	AMP-binding enzyme; Region: AMP-binding; cl15778
449447011719	acyl-CoA synthetase; Validated; Region: PRK08308
449447011720	Phosphopantetheine attachment site; Region: PP-binding; cl09936
449447011721	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447011722	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447011723	Probable transposase; Region: OrfB_IS605; pfam01385
449447011724	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447011725	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
449447011726	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
449447011727	Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome.  The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223
449447011728	multidrug resistance protein (mdr1); Provisional; Region: PTZ00265
449447011729	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102
449447011730	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
449447011731	GUN4-like; Region: GUN4; pfam05419
449447011732	Integrase core domain; Region: rve; cl01316
449447011733	Helix-turn-helix domains; Region: HTH; cl00088
449447011734	Winged helix-turn helix; Region: HTH_29; pfam13551
449447011735	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447011736	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447011737	Probable transposase; Region: OrfB_IS605; pfam01385
449447011738	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447011739	Protein of unknown function (DUF541); Region: SIMPL; cl01077
449447011740	Probable transposase; Region: OrfB_IS605; pfam01385
449447011741	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
449447011742	Sulfatase; Region: Sulfatase; cl10460
449447011743	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102
449447011744	Protein of unknown function (DUF4127); Region: DUF4127; pfam13552
449447011745	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
449447011746	catalytic residues [active]
449447011747	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
449447011748	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
449447011749	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
449447011750	cysteine synthase; Region: PLN02565
449447011751	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
449447011752	dimer interface [polypeptide binding]; other site
449447011753	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447011754	catalytic residue [active]
449447011755	replicative DNA helicase; Provisional; Region: PRK05595
449447011756	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447011757	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447011758	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447011759	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
449447011760	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
449447011761	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
449447011762	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
449447011763	dimer interface [polypeptide binding]; other site
449447011764	putative functional site; other site
449447011765	putative MPT binding site; other site
449447011766	Glutaminase; Region: Glutaminase; cl00907
449447011767	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
449447011768	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
449447011769	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447011770	binding surface
449447011771	TPR motif; other site
449447011772	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447011773	binding surface
449447011774	TPR motif; other site
449447011775	TIGR03032 family protein; Region: TIGR03032
449447011776	Tetratricopeptide repeat; Region: TPR_6; pfam13174
449447011777	DDE superfamily endonuclease; Region: DDE_5; cl02413
449447011778	Integrase core domain; Region: rve; cl01316
449447011779	Helix-turn-helix domains; Region: HTH; cl00088
449447011780	Winged helix-turn helix; Region: HTH_29; pfam13551
449447011781	Helix-turn-helix domains; Region: HTH; cl00088
449447011782	Calx-beta domain; Region: Calx-beta; cl02522
449447011783	Calx-beta domain; Region: Calx-beta; cl02522
449447011784	Calx-beta domain; Region: Calx-beta; cl02522
449447011785	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
449447011786	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447011787	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447011788	ARD/ARD' family; Region: ARD; pfam03079
449447011789	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
449447011790	Helix-turn-helix domains; Region: HTH; cl00088
449447011791	Helix-turn-helix domains; Region: HTH; cl00088
449447011792	Integrase core domain; Region: rve; cl01316
449447011793	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
449447011794	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
449447011795	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
449447011796	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447011797	putative active site [active]
449447011798	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447011799	putative active site [active]
449447011800	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447011801	putative active site [active]
449447011802	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447011803	putative active site [active]
449447011804	cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510
449447011805	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447011806	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
449447011807	catalytic motif [active]
449447011808	Zn binding site [ion binding]; other site
449447011809	Peptidase family M48; Region: Peptidase_M48; cl12018
449447011810	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397
449447011811	PDGLE domain; Region: PDGLE; cl07986
449447011812	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
449447011813	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
449447011814	Walker A/P-loop; other site
449447011815	ATP binding site [chemical binding]; other site
449447011816	Q-loop/lid; other site
449447011817	ABC transporter signature motif; other site
449447011818	Walker B; other site
449447011819	D-loop; other site
449447011820	H-loop/switch region; other site
449447011821	HEAT repeats; Region: HEAT_2; pfam13646
449447011822	Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449
449447011823	Domon-like ligand-binding domains; Region: DOMON_like; cd00241
449447011824	putative ligand binding site [chemical binding]; other site
449447011825	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447011826	structural tetrad; other site
449447011827	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
449447011828	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
449447011829	dimerization interface [polypeptide binding]; other site
449447011830	active site
449447011831	metal binding site [ion binding]; metal-binding site
449447011832	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
449447011833	dsRNA binding site [nucleotide binding]; other site
449447011834	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
449447011835	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
449447011836	adaptive-response sensory kinase; Validated; Region: PRK09303
449447011837	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
449447011838	tetramer interface [polypeptide binding]; other site
449447011839	dimer interface [polypeptide binding]; other site
449447011840	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447011841	dimer interface [polypeptide binding]; other site
449447011842	phosphorylation site [posttranslational modification]
449447011843	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447011844	ATP binding site [chemical binding]; other site
449447011845	Mg2+ binding site [ion binding]; other site
449447011846	G-X-G motif; other site
449447011847	Uncharacterized conserved protein [Function unknown]; Region: COG1543
449447011848	Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074
449447011849	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
449447011850	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447011851	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447011852	Probable transposase; Region: OrfB_IS605; pfam01385
449447011853	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447011854	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
449447011855	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447011856	active site
449447011857	ATP binding site [chemical binding]; other site
449447011858	substrate binding site [chemical binding]; other site
449447011859	activation loop (A-loop); other site
449447011860	Protein of unknown function (DUF422); Region: DUF422; cl00991
449447011861	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
449447011862	active site
449447011863	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
449447011864	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447011865	Uncharacterized BCR, COG1649; Region: DUF187; cl15398
449447011866	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
449447011867	catalytic triad [active]
449447011868	Bacterial SH3 domain; Region: SH3_3; cl02551
449447011869	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
449447011870	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
449447011871	active site
449447011872	metal binding site [ion binding]; metal-binding site
449447011873	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447011874	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447011875	Transposase [DNA replication, recombination, and repair]; Region: COG5433
449447011876	phosphate acetyltransferase; Reviewed; Region: PRK05632
449447011877	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447011878	DRTGG domain; Region: DRTGG; cl12147
449447011879	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
449447011880	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
449447011881	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447011882	2TM domain; Region: 2TM; pfam13239
449447011883	Protein of unknown function (DUF3181); Region: DUF3181; pfam11378
449447011884	alanine dehydrogenase; Region: alaDH; TIGR00518
449447011885	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
449447011886	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447011887	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
449447011888	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
449447011889	cofactor binding site; other site
449447011890	DNA binding site [nucleotide binding]
449447011891	substrate interaction site [chemical binding]; other site
449447011892	XisI protein; Region: XisI; pfam08869
449447011893	Calx-beta domain; Region: Calx-beta; cl02522
449447011894	Calx-beta domain; Region: Calx-beta; cl02522
449447011895	Calx-beta domain; Region: Calx-beta; cl02522
449447011896	ARD/ARD' family; Region: ARD; pfam03079
449447011897	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
449447011898	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
449447011899	putative active site [active]
449447011900	TIGR03032 family protein; Region: TIGR03032
449447011901	Chromate transporter; Region: Chromate_transp; pfam02417
449447011902	Chromate transporter; Region: Chromate_transp; pfam02417
449447011903	ATP phosphoribosyltransferase; Region: HisG; cl15266
449447011904	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
449447011905	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
449447011906	motif II; other site
449447011907	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
449447011908	intersubunit interface [polypeptide binding]; other site
449447011909	active site
449447011910	catalytic residue [active]
449447011911	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
449447011912	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
449447011913	substrate binding site [chemical binding]; other site
449447011914	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
449447011915	substrate binding site [chemical binding]; other site
449447011916	ligand binding site [chemical binding]; other site
449447011917	Protein of unknown function (DUF2584); Region: DUF2584; pfam10763
449447011918	Domain of unknown function (DUF4415); Region: DUF4415; cl01401
449447011919	XisI protein; Region: XisI; pfam08869
449447011920	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
449447011921	urease subunit alpha; Reviewed; Region: ureC; PRK13207
449447011922	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
449447011923	subunit interactions [polypeptide binding]; other site
449447011924	active site
449447011925	flap region; other site
449447011926	Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539
449447011927	CHAT domain; Region: CHAT; pfam12770
449447011928	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447011929	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447011930	XisI protein; Region: XisI; pfam08869
449447011931	XisH protein; Region: XisH; pfam08814
449447011932	TIR domain; Region: TIR_2; cl15770
449447011933	Protein of unknown function (DUF433); Region: DUF433; cl01030
449447011934	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447011935	Transposase domain (DUF772); Region: DUF772; cl15789
449447011936	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
449447011937	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
449447011938	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
449447011939	putative active site [active]
449447011940	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
449447011941	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
449447011942	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447011943	Helix-turn-helix domains; Region: HTH; cl00088
449447011944	Winged helix-turn helix; Region: HTH_29; pfam13551
449447011945	Helix-turn-helix domains; Region: HTH; cl00088
449447011946	Integrase core domain; Region: rve; cl01316
449447011947	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
449447011948	trimer interface [polypeptide binding]; other site
449447011949	dimer interface [polypeptide binding]; other site
449447011950	putative active site [active]
449447011951	magnesium chelatase subunit H; Provisional; Region: PLN03241
449447011952	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
449447011953	Flavin Reductases; Region: FlaRed; cl00801
449447011954	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
449447011955	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
449447011956	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
449447011957	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
449447011958	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
449447011959	Flavin Reductases; Region: FlaRed; cl00801
449447011960	Acylphosphatase; Region: Acylphosphatase; cl00551
449447011961	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
449447011962	HypF finger; Region: zf-HYPF; pfam07503
449447011963	HypF finger; Region: zf-HYPF; pfam07503
449447011964	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
449447011965	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
449447011966	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
449447011967	active site
449447011968	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
449447011969	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
449447011970	substrate binding site [chemical binding]; other site
449447011971	hexamer interface [polypeptide binding]; other site
449447011972	metal binding site [ion binding]; metal-binding site
449447011973	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
449447011974	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
449447011975	inhibitor binding site; inhibition site
449447011976	catalytic motif [active]
449447011977	Catalytic residue [active]
449447011978	Active site flap [active]
449447011979	Protein of unknown function (DUF3252); Region: DUF3252; pfam11623
449447011980	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
449447011981	active site
449447011982	Hydrogenase formation hypA family; Region: HypD; cl12072
449447011983	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409
449447011984	HupF/HypC family; Region: HupF_HypC; cl00394
449447011985	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
449447011986	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
449447011987	TPP-binding site [chemical binding]; other site
449447011988	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
449447011989	PYR/PP interface [polypeptide binding]; other site
449447011990	dimer interface [polypeptide binding]; other site
449447011991	TPP binding site [chemical binding]; other site
449447011992	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
449447011993	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
449447011994	Clp amino terminal domain; Region: Clp_N; pfam02861
449447011995	Clp amino terminal domain; Region: Clp_N; pfam02861
449447011996	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447011997	Walker A motif; other site
449447011998	ATP binding site [chemical binding]; other site
449447011999	Walker B motif; other site
449447012000	arginine finger; other site
449447012001	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447012002	Walker A motif; other site
449447012003	ATP binding site [chemical binding]; other site
449447012004	Walker B motif; other site
449447012005	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
449447012006	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447012007	putative active site [active]
449447012008	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
449447012009	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
449447012010	TM-ABC transporter signature motif; other site
449447012011	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
449447012012	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447012013	Protein of unknown function (DUF721); Region: DUF721; cl02324
449447012014	phage shock protein A; Region: phageshock_pspA; TIGR02977
449447012015	PspA/IM30 family; Region: PspA_IM30; pfam04012
449447012016	PspA/IM30 family; Region: PspA_IM30; pfam04012
449447012017	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
449447012018	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
449447012019	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
449447012020	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447012021	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
449447012022	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
449447012023	multifunctional aminopeptidase A; Provisional; Region: PRK00913
449447012024	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
449447012025	interface (dimer of trimers) [polypeptide binding]; other site
449447012026	Substrate-binding/catalytic site; other site
449447012027	Zn-binding sites [ion binding]; other site
449447012028	Probable transposase; Region: OrfB_IS605; pfam01385
449447012029	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447012030	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447012031	TPR repeat; Region: TPR_11; pfam13414
449447012032	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447012033	binding surface
449447012034	TPR motif; other site
449447012035	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447012036	binding surface
449447012037	TPR repeat; Region: TPR_11; pfam13414
449447012038	TPR motif; other site
449447012039	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
449447012040	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
449447012041	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
449447012042	putative active site [active]
449447012043	putative NTP binding site [chemical binding]; other site
449447012044	putative nucleic acid binding site [nucleotide binding]; other site
449447012045	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
449447012046	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
449447012047	active site
449447012048	FtsH Extracellular; Region: FtsH_ext; pfam06480
449447012049	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
449447012050	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447012051	Walker A motif; other site
449447012052	ATP binding site [chemical binding]; other site
449447012053	Walker B motif; other site
449447012054	arginine finger; other site
449447012055	Peptidase family M41; Region: Peptidase_M41; pfam01434
449447012056	Helix-turn-helix domains; Region: HTH; cl00088
449447012057	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
449447012058	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
449447012059	putative dimerization interface [polypeptide binding]; other site
449447012060	Sulfate transporter family; Region: Sulfate_transp; cl15842
449447012061	Domain of unknown function (DUF897); Region: DUF897; cl01312
449447012062	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
449447012063	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
449447012064	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
449447012065	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
449447012066	Protein of unknown function (DUF541); Region: SIMPL; cl01077
449447012067	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447012068	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447012069	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447012070	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
449447012071	ZPR1 zinc-finger domain; Region: zf-ZPR1; pfam03367
449447012072	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447012073	Protein of unknown function, DUF642; Region: DUF642; pfam04862
449447012074	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447012075	putative active site [active]
449447012076	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
449447012077	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
449447012078	hinge; other site
449447012079	active site
449447012080	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
449447012081	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
449447012082	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
449447012083	Winged helix-turn helix; Region: HTH_29; pfam13551
449447012084	Helix-turn-helix domains; Region: HTH; cl00088
449447012085	Helix-turn-helix domains; Region: HTH; cl00088
449447012086	Integrase core domain; Region: rve; cl01316
449447012087	AAA domain; Region: AAA_33; pfam13671
449447012088	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447012089	active site
449447012090	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
449447012091	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
449447012092	purine monophosphate binding site [chemical binding]; other site
449447012093	dimer interface [polypeptide binding]; other site
449447012094	putative catalytic residues [active]
449447012095	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
449447012096	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
449447012097	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447012098	Transposase domain (DUF772); Region: DUF772; cl15789
449447012099	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
449447012100	putative active site [active]
449447012101	PemK-like protein; Region: PemK; cl00995
449447012102	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
449447012103	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
449447012104	MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738
449447012105	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447012106	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
449447012107	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
449447012108	NAD binding site [chemical binding]; other site
449447012109	homodimer interface [polypeptide binding]; other site
449447012110	active site
449447012111	substrate binding site [chemical binding]; other site
449447012112	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
449447012113	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
449447012114	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447012115	active site
449447012116	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
449447012117	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
449447012118	active site
449447012119	substrate binding site [chemical binding]; other site
449447012120	cosubstrate binding site; other site
449447012121	catalytic site [active]
449447012122	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447012123	putative active site [active]
449447012124	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447012125	putative active site [active]
449447012126	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
449447012127	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
449447012128	HIGH motif; other site
449447012129	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
449447012130	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
449447012131	active site
449447012132	KMSKS motif; other site
449447012133	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
449447012134	tRNA binding surface [nucleotide binding]; other site
449447012135	anticodon binding site; other site
449447012136	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
449447012137	isocitrate dehydrogenase; Validated; Region: PRK07362
449447012138	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
449447012139	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
449447012140	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
449447012141	Helix-turn-helix domains; Region: HTH; cl00088
449447012142	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447012143	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
449447012144	active site
449447012145	substrate binding site [chemical binding]; other site
449447012146	ATP binding site [chemical binding]; other site
449447012147	activation loop (A-loop); other site
449447012148	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447012149	structural tetrad; other site
449447012150	PQQ-like domain; Region: PQQ_2; pfam13360
449447012151	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
449447012152	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912
449447012153	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
449447012154	oligomeric interface; other site
449447012155	putative active site [active]
449447012156	homodimer interface [polypeptide binding]; other site
449447012157	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447012158	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447012159	Probable transposase; Region: OrfB_IS605; pfam01385
449447012160	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447012161	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
449447012162	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
449447012163	TPP-binding site; other site
449447012164	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
449447012165	PYR/PP interface [polypeptide binding]; other site
449447012166	dimer interface [polypeptide binding]; other site
449447012167	TPP binding site [chemical binding]; other site
449447012168	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
449447012169	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
449447012170	AIR carboxylase; Region: AIRC; cl00310
449447012171	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
449447012172	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
449447012173	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
449447012174	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
449447012175	dihydrodipicolinate synthase; Region: dapA; TIGR00674
449447012176	dimer interface [polypeptide binding]; other site
449447012177	active site
449447012178	catalytic residue [active]
449447012179	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
449447012180	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447012181	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
449447012182	trigger factor; Provisional; Region: tig; PRK01490
449447012183	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
449447012184	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
449447012185	Clp protease; Region: CLP_protease; pfam00574
449447012186	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
449447012187	oligomer interface [polypeptide binding]; other site
449447012188	active site residues [active]
449447012189	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
449447012190	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
449447012191	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
449447012192	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447012193	Walker A motif; other site
449447012194	ATP binding site [chemical binding]; other site
449447012195	Walker B motif; other site
449447012196	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
449447012197	PemK-like protein; Region: PemK; cl00995
449447012198	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
449447012199	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
449447012200	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
449447012201	catalytic triad [active]
449447012202	dimer interface [polypeptide binding]; other site
449447012203	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
449447012204	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447012205	Probable transposase; Region: OrfB_IS605; pfam01385
449447012206	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447012207	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
449447012208	YcfA-like protein; Region: YcfA; cl00752
449447012209	Ferritin-like domain; Region: Ferritin; pfam00210
449447012210	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
449447012211	dimerization interface [polypeptide binding]; other site
449447012212	DPS ferroxidase diiron center [ion binding]; other site
449447012213	ion pore; other site
449447012214	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447012215	active site
449447012216	ATP binding site [chemical binding]; other site
449447012217	substrate binding site [chemical binding]; other site
449447012218	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447012219	Transposase domain (DUF772); Region: DUF772; cl15789
449447012220	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
449447012221	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
449447012222	Dynamin family; Region: Dynamin_N; pfam00350
449447012223	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
449447012224	G1 box; other site
449447012225	GTP/Mg2+ binding site [chemical binding]; other site
449447012226	Switch I region; other site
449447012227	G2 box; other site
449447012228	Switch II region; other site
449447012229	G3 box; other site
449447012230	G4 box; other site
449447012231	G5 box; other site
449447012232	Domain of unknown function (DUF697); Region: DUF697; cl12064
449447012233	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
449447012234	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
449447012235	putative switch regulator; other site
449447012236	non-specific DNA interactions [nucleotide binding]; other site
449447012237	DNA binding site [nucleotide binding]
449447012238	sequence specific DNA binding site [nucleotide binding]; other site
449447012239	putative cAMP binding site [chemical binding]; other site
449447012240	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
449447012241	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
449447012242	DNA binding residues [nucleotide binding]
449447012243	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
449447012244	catalytic residues [active]
449447012245	catalytic nucleophile [active]
449447012246	Probable transposase; Region: OrfB_IS605; pfam01385
449447012247	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447012248	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
449447012249	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
449447012250	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
449447012251	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
449447012252	Walker A/P-loop; other site
449447012253	ATP binding site [chemical binding]; other site
449447012254	Q-loop/lid; other site
449447012255	ABC transporter signature motif; other site
449447012256	Walker B; other site
449447012257	D-loop; other site
449447012258	H-loop/switch region; other site
449447012259	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
449447012260	Transposase IS200 like; Region: Y1_Tnp; cl00848
449447012261	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
449447012262	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447012263	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
449447012264	Transposase IS200 like; Region: Y1_Tnp; cl00848
449447012265	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447012266	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447012267	Probable transposase; Region: OrfB_IS605; pfam01385
449447012268	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447012269	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447012270	NAD(P) binding site [chemical binding]; other site
449447012271	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; cl15292
449447012272	Protein of unknown function (DUF3353); Region: DUF3353; pfam11833
449447012273	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
449447012274	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
449447012275	motif II; other site
449447012276	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391