-- dump date 20120504_152648 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1032480000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 1032480000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480000003 Walker A motif; other site 1032480000004 ATP binding site [chemical binding]; other site 1032480000005 Walker B motif; other site 1032480000006 arginine finger; other site 1032480000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1032480000008 DnaA box-binding interface [nucleotide binding]; other site 1032480000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1032480000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1032480000011 putative DNA binding surface [nucleotide binding]; other site 1032480000012 dimer interface [polypeptide binding]; other site 1032480000013 beta-clamp/clamp loader binding surface; other site 1032480000014 beta-clamp/translesion DNA polymerase binding surface; other site 1032480000015 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1032480000016 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480000017 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1032480000018 phosphopeptide binding site; other site 1032480000019 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1032480000020 phosphopeptide binding site; other site 1032480000021 ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with processes...; Region: ABCG_EPDR; cd03213 1032480000022 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1032480000023 Walker A/P-loop; other site 1032480000024 ATP binding site [chemical binding]; other site 1032480000025 Q-loop/lid; other site 1032480000026 ABC transporter signature motif; other site 1032480000027 Walker B; other site 1032480000028 D-loop; other site 1032480000029 H-loop/switch region; other site 1032480000030 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1032480000031 Protein of unknown function (DUF721); Region: DUF721; cl02324 1032480000032 recombination protein F; Reviewed; Region: recF; PRK00064 1032480000033 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 1032480000034 Walker A/P-loop; other site 1032480000035 ATP binding site [chemical binding]; other site 1032480000036 Q-loop/lid; other site 1032480000037 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480000038 ABC transporter signature motif; other site 1032480000039 Walker B; other site 1032480000040 D-loop; other site 1032480000041 H-loop/switch region; other site 1032480000042 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1032480000043 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1032480000044 active site 1032480000045 ATP binding site [chemical binding]; other site 1032480000046 substrate binding site [chemical binding]; other site 1032480000047 activation loop (A-loop); other site 1032480000048 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1032480000049 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1032480000050 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1032480000051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480000052 Mg2+ binding site [ion binding]; other site 1032480000053 G-X-G motif; other site 1032480000054 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1032480000055 anchoring element; other site 1032480000056 dimer interface [polypeptide binding]; other site 1032480000057 ATP binding site [chemical binding]; other site 1032480000058 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1032480000059 active site 1032480000060 putative metal-binding site [ion binding]; other site 1032480000061 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1032480000062 DNA gyrase subunit A; Validated; Region: PRK05560 1032480000063 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 1032480000064 CAP-like domain; other site 1032480000065 active site 1032480000066 primary dimer interface [polypeptide binding]; other site 1032480000067 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1032480000068 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1032480000069 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1032480000070 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1032480000071 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1032480000072 ApbE family; Region: ApbE; cl00643 1032480000073 FMN-binding domain; Region: FMN_bind; cl01081 1032480000074 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 1032480000075 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1032480000076 FAD binding pocket [chemical binding]; other site 1032480000077 conserved FAD binding motif [chemical binding]; other site 1032480000078 phosphate binding motif [ion binding]; other site 1032480000079 beta-alpha-beta structure motif; other site 1032480000080 NAD binding pocket [chemical binding]; other site 1032480000081 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1032480000082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480000083 active site 1032480000084 phosphorylation site [posttranslational modification] 1032480000085 intermolecular recognition site; other site 1032480000086 dimerization interface [polypeptide binding]; other site 1032480000087 Helix-turn-helix domains; Region: HTH; cl00088 1032480000088 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1032480000089 dimer interface [polypeptide binding]; other site 1032480000090 phosphorylation site [posttranslational modification] 1032480000091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480000092 ATP binding site [chemical binding]; other site 1032480000093 Mg2+ binding site [ion binding]; other site 1032480000094 G-X-G motif; other site 1032480000095 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1032480000096 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480000097 short chain dehydrogenase; Provisional; Region: PRK06197 1032480000098 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1032480000099 putative NAD(P) binding site [chemical binding]; other site 1032480000100 active site 1032480000101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480000102 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480000103 potential frameshift: common BLAST hit: gi|302865121|ref|YP_003833758.1| helix-turn-helix domain-containing protein 1032480000104 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480000105 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 1032480000106 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1032480000107 dimerization interface [polypeptide binding]; other site 1032480000108 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1032480000109 dimer interface [polypeptide binding]; other site 1032480000110 phosphorylation site [posttranslational modification] 1032480000111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480000112 ATP binding site [chemical binding]; other site 1032480000113 Mg2+ binding site [ion binding]; other site 1032480000114 G-X-G motif; other site 1032480000115 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1032480000116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480000117 active site 1032480000118 phosphorylation site [posttranslational modification] 1032480000119 intermolecular recognition site; other site 1032480000120 dimerization interface [polypeptide binding]; other site 1032480000121 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1032480000122 DNA binding site [nucleotide binding] 1032480000123 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1032480000124 VanZ like family; Region: VanZ; cl01971 1032480000125 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1032480000126 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480000127 YCII-related domain; Region: YCII; cl00999 1032480000128 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1032480000129 homodimer interface [polypeptide binding]; other site 1032480000130 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1032480000131 active site 1032480000132 TDP-binding site; other site 1032480000133 acceptor substrate-binding pocket; other site 1032480000134 Phospholipid methyltransferase; Region: PEMT; cl00763 1032480000135 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480000136 dimerization interface [polypeptide binding]; other site 1032480000137 putative DNA binding site [nucleotide binding]; other site 1032480000138 putative Zn2+ binding site [ion binding]; other site 1032480000139 potential frameshift: common BLAST hit: gi|300790366|ref|YP_003770657.1| major facilitator transporter 1032480000140 H+ Antiporter protein; Region: 2A0121; TIGR00900 1032480000141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480000142 H+ Antiporter protein; Region: 2A0121; TIGR00900 1032480000143 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480000144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480000145 active site 1032480000146 phosphorylation site [posttranslational modification] 1032480000147 intermolecular recognition site; other site 1032480000148 dimerization interface [polypeptide binding]; other site 1032480000149 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480000150 DNA binding residues [nucleotide binding] 1032480000151 dimerization interface [polypeptide binding]; other site 1032480000152 Histidine kinase; Region: HisKA_3; pfam07730 1032480000153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1032480000154 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1032480000155 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1032480000156 Walker A/P-loop; other site 1032480000157 ATP binding site [chemical binding]; other site 1032480000158 Q-loop/lid; other site 1032480000159 ABC transporter signature motif; other site 1032480000160 Walker B; other site 1032480000161 D-loop; other site 1032480000162 H-loop/switch region; other site 1032480000163 isoleucyl-tRNA synthetase; Region: ileS; TIGR00392 1032480000164 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1032480000165 active site 1032480000166 HIGH motif; other site 1032480000167 nucleotide binding site [chemical binding]; other site 1032480000168 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1032480000169 active site 1032480000170 KMSKS motif; other site 1032480000171 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1032480000172 tRNA binding surface [nucleotide binding]; other site 1032480000173 anticodon binding site; other site 1032480000174 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1032480000175 Phosphate transporter family; Region: PHO4; cl00396 1032480000176 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1032480000177 Sulfate transporter family; Region: Sulfate_transp; cl15842 1032480000178 Sulfate transporter family; Region: Sulfate_transp; cl15842 1032480000179 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1032480000180 Predicted ATPase [General function prediction only]; Region: COG3899 1032480000181 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480000182 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1032480000183 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480000184 DNA binding residues [nucleotide binding] 1032480000185 dimerization interface [polypeptide binding]; other site 1032480000186 CHAD domain; Region: CHAD; cl10506 1032480000187 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1032480000188 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1032480000189 P-loop; other site 1032480000190 Magnesium ion binding site [ion binding]; other site 1032480000191 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1032480000192 Magnesium ion binding site [ion binding]; other site 1032480000193 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1032480000194 active site clefts [active] 1032480000195 zinc binding site [ion binding]; other site 1032480000196 dimer interface [polypeptide binding]; other site 1032480000197 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1032480000198 active site 1032480000199 catalytic residues [active] 1032480000200 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1032480000201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 1032480000202 CHAT domain; Region: CHAT; pfam12770 1032480000203 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1032480000204 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480000205 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480000206 S-adenosylmethionine binding site [chemical binding]; other site 1032480000207 NurA domain; Region: NurA; cl09134 1032480000208 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480000209 AAA domain; Region: AAA_23; pfam13476 1032480000210 Walker A/P-loop; other site 1032480000211 ATP binding site [chemical binding]; other site 1032480000212 Q-loop/lid; other site 1032480000213 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480000214 ABC transporter signature motif; other site 1032480000215 Walker B; other site 1032480000216 D-loop; other site 1032480000217 H-loop/switch region; other site 1032480000218 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1032480000219 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1032480000220 active site 1032480000221 metal binding site [ion binding]; metal-binding site 1032480000222 DNA binding site [nucleotide binding] 1032480000223 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1032480000224 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1032480000225 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480000226 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1032480000227 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480000228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480000229 active site 1032480000230 phosphorylation site [posttranslational modification] 1032480000231 intermolecular recognition site; other site 1032480000232 dimerization interface [polypeptide binding]; other site 1032480000233 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480000234 DNA binding residues [nucleotide binding] 1032480000235 dimerization interface [polypeptide binding]; other site 1032480000236 sensory histidine kinase UhpB; Provisional; Region: PRK11644 1032480000237 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1032480000238 Response regulator receiver domain; Region: Response_reg; pfam00072 1032480000239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480000240 active site 1032480000241 phosphorylation site [posttranslational modification] 1032480000242 intermolecular recognition site; other site 1032480000243 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1032480000244 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1032480000245 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1032480000246 Histidine kinase; Region: HisKA_3; pfam07730 1032480000247 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1032480000248 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1032480000249 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480000250 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1032480000251 active site 1032480000252 metal binding site [ion binding]; metal-binding site 1032480000253 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 1032480000254 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1032480000255 DNA binding residues [nucleotide binding] 1032480000256 putative dimer interface [polypeptide binding]; other site 1032480000257 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480000258 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 1032480000259 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1032480000260 putative dimer interface [polypeptide binding]; other site 1032480000261 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480000262 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480000263 non-specific DNA binding site [nucleotide binding]; other site 1032480000264 salt bridge; other site 1032480000265 sequence-specific DNA binding site [nucleotide binding]; other site 1032480000266 Predicted ATPase [General function prediction only]; Region: COG3903 1032480000267 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 1032480000268 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1032480000269 Moco binding site; other site 1032480000270 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1032480000271 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1032480000272 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480000273 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480000274 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1032480000275 Putative cyclase; Region: Cyclase; cl00814 1032480000276 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 1032480000277 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 1032480000278 Helix-turn-helix domains; Region: HTH; cl00088 1032480000279 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1032480000280 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1032480000281 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1032480000282 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1032480000283 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1032480000284 binding surface 1032480000285 TPR motif; other site 1032480000286 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1032480000287 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1032480000288 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1032480000289 binding surface 1032480000290 TPR motif; other site 1032480000291 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1032480000292 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1032480000293 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1032480000294 TPR motif; other site 1032480000295 binding surface 1032480000296 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1032480000297 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1032480000298 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1032480000299 binding surface 1032480000300 TPR motif; other site 1032480000301 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1032480000302 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1032480000303 Helix-turn-helix domains; Region: HTH; cl00088 1032480000304 Integrase core domain; Region: rve; cl01316 1032480000305 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 1032480000306 Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651 1032480000307 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1032480000308 Protein of unknown function (DUF555); Region: DUF555; cl00818 1032480000309 Transglycosylase; Region: Transgly; cl07896 1032480000310 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1032480000311 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1032480000312 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1032480000313 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 1032480000314 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 1032480000315 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1032480000316 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1032480000317 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1032480000318 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1032480000319 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1032480000320 catalytic residue [active] 1032480000321 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480000322 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480000323 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1032480000324 EamA-like transporter family; Region: EamA; cl01037 1032480000325 EamA-like transporter family; Region: EamA; cl01037 1032480000326 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1032480000327 putative active site [active] 1032480000328 putative DNA binding site [nucleotide binding]; other site 1032480000329 putative phosphate binding site [ion binding]; other site 1032480000330 putative catalytic site [active] 1032480000331 metal binding site A [ion binding]; metal-binding site 1032480000332 putative AP binding site [nucleotide binding]; other site 1032480000333 putative metal binding site B [ion binding]; other site 1032480000334 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1032480000335 FAD binding domain; Region: FAD_binding_4; pfam01565 1032480000336 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1032480000337 putative acyl-acceptor binding pocket; other site 1032480000338 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1032480000339 classical (c) SDRs; Region: SDR_c; cd05233 1032480000340 NAD(P) binding site [chemical binding]; other site 1032480000341 active site 1032480000342 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 1032480000343 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1032480000344 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480000345 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1032480000346 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 1032480000347 putative NAD(P) binding site [chemical binding]; other site 1032480000348 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1032480000349 active site 1032480000350 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1032480000351 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1032480000352 Helix-turn-helix domains; Region: HTH; cl00088 1032480000353 putative transposase OrfB; Reviewed; Region: PHA02517 1032480000354 HTH-like domain; Region: HTH_21; pfam13276 1032480000355 Integrase core domain; Region: rve; cl01316 1032480000356 Integrase core domain; Region: rve_3; cl15866 1032480000357 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 1032480000358 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1032480000359 dimerization interface [polypeptide binding]; other site 1032480000360 active site 1032480000361 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1032480000362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480000363 propionate/acetate kinase; Provisional; Region: PRK12379 1032480000364 Acetokinase family; Region: Acetate_kinase; cl01029 1032480000365 phosphate acetyltransferase; Reviewed; Region: PRK05632 1032480000366 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480000367 DRTGG domain; Region: DRTGG; cl12147 1032480000368 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 1032480000369 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1032480000370 Restriction endonuclease; Region: Mrr_cat; cl00516 1032480000371 Helix-turn-helix domains; Region: HTH; cl00088 1032480000372 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1032480000373 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1032480000374 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1032480000375 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480000376 PAAR motif; Region: PAAR_motif; cl15808 1032480000377 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1032480000378 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480000379 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480000380 active site 1032480000381 phosphorylation site [posttranslational modification] 1032480000382 intermolecular recognition site; other site 1032480000383 dimerization interface [polypeptide binding]; other site 1032480000384 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480000385 DNA binding residues [nucleotide binding] 1032480000386 dimerization interface [polypeptide binding]; other site 1032480000387 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1032480000388 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480000389 Walker A motif; other site 1032480000390 ATP binding site [chemical binding]; other site 1032480000391 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1032480000392 MULE transposase domain; Region: MULE; pfam10551 1032480000393 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1032480000394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1032480000395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480000396 dimer interface [polypeptide binding]; other site 1032480000397 conserved gate region; other site 1032480000398 putative PBP binding loops; other site 1032480000399 ABC-ATPase subunit interface; other site 1032480000400 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1032480000401 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480000402 Helix-turn-helix domains; Region: HTH; cl00088 1032480000403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480000404 S-adenosylmethionine binding site [chemical binding]; other site 1032480000405 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480000406 Helix-turn-helix domains; Region: HTH; cl00088 1032480000407 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1032480000408 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1032480000409 MULE transposase domain; Region: MULE; pfam10551 1032480000410 Integrase core domain; Region: rve; cl01316 1032480000411 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1032480000412 Helix-turn-helix domains; Region: HTH; cl00088 1032480000413 Integrase core domain; Region: rve; cl01316 1032480000414 HTH-like domain; Region: HTH_21; pfam13276 1032480000415 Integrase core domain; Region: rve; cl01316 1032480000416 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1032480000417 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1032480000418 P-loop; other site 1032480000419 Magnesium ion binding site [ion binding]; other site 1032480000420 Histidine kinase; Region: HisKA_3; pfam07730 1032480000421 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1032480000422 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1032480000423 putative active site [active] 1032480000424 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1032480000425 DNA binding site [nucleotide binding] 1032480000426 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480000427 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480000428 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480000429 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480000430 DNA binding site [nucleotide binding] 1032480000431 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480000432 ligand binding site [chemical binding]; other site 1032480000433 dimerization interface [polypeptide binding]; other site 1032480000434 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1032480000435 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1032480000436 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1032480000437 DXD motif; other site 1032480000438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480000439 active site 1032480000440 phosphorylation site [posttranslational modification] 1032480000441 intermolecular recognition site; other site 1032480000442 dimerization interface [polypeptide binding]; other site 1032480000443 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1032480000444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480000445 putative transporter; Provisional; Region: PRK10504 1032480000446 putative substrate translocation pore; other site 1032480000447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480000448 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1032480000449 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1032480000450 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1032480000451 Helix-turn-helix domains; Region: HTH; cl00088 1032480000452 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1032480000453 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1032480000454 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1032480000455 putative catalytic site [active] 1032480000456 putative metal binding site [ion binding]; other site 1032480000457 putative phosphate binding site [ion binding]; other site 1032480000458 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480000459 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480000460 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480000461 dimerization interface [polypeptide binding]; other site 1032480000462 ligand binding site [chemical binding]; other site 1032480000463 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1032480000464 putative hydrophobic ligand binding site [chemical binding]; other site 1032480000465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480000466 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480000467 putative substrate translocation pore; other site 1032480000468 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480000469 Ligand Binding Site [chemical binding]; other site 1032480000470 sucrose phosphorylase; Provisional; Region: PRK13840 1032480000471 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 1032480000472 active site 1032480000473 homodimer interface [polypeptide binding]; other site 1032480000474 catalytic site [active] 1032480000475 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480000476 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480000477 DNA binding site [nucleotide binding] 1032480000478 domain linker motif; other site 1032480000479 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480000480 dimerization interface [polypeptide binding]; other site 1032480000481 ligand binding site [chemical binding]; other site 1032480000482 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1032480000483 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1032480000484 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 1032480000485 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 1032480000486 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1032480000487 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1032480000488 Helix-turn-helix domains; Region: HTH; cl00088 1032480000489 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480000490 dimerization interface [polypeptide binding]; other site 1032480000491 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1032480000492 putative active site [active] 1032480000493 metal binding site [ion binding]; metal-binding site 1032480000494 Clp protease ATP binding subunit; Region: clpC; CHL00095 1032480000495 hypothetical protein; Provisional; Region: PRK11239 1032480000496 Protein of unknown function, DUF480; Region: DUF480; cl01209 1032480000497 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 1032480000498 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480000499 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1032480000500 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1032480000501 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1032480000502 substrate binding site [chemical binding]; other site 1032480000503 ATP binding site [chemical binding]; other site 1032480000504 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1032480000505 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1032480000506 NAD binding site [chemical binding]; other site 1032480000507 sugar binding site [chemical binding]; other site 1032480000508 divalent metal binding site [ion binding]; other site 1032480000509 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1032480000510 dimer interface [polypeptide binding]; other site 1032480000511 TPR repeat; Region: TPR_11; pfam13414 1032480000512 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1032480000513 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1032480000514 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 1032480000515 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1032480000516 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1032480000517 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1032480000518 active site 1032480000519 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 1032480000520 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1032480000521 Short C-terminal domain; Region: SHOCT; cl01373 1032480000522 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1032480000523 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1032480000524 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1032480000525 putative phosphate binding site [ion binding]; other site 1032480000526 putative catalytic site [active] 1032480000527 active site 1032480000528 metal binding site A [ion binding]; metal-binding site 1032480000529 DNA binding site [nucleotide binding] 1032480000530 putative AP binding site [nucleotide binding]; other site 1032480000531 putative metal binding site B [ion binding]; other site 1032480000532 H+ Antiporter protein; Region: 2A0121; TIGR00900 1032480000533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480000534 putative substrate translocation pore; other site 1032480000535 Helix-turn-helix domains; Region: HTH; cl00088 1032480000536 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1032480000537 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1032480000538 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480000539 DNA-binding site [nucleotide binding]; DNA binding site 1032480000540 FCD domain; Region: FCD; cl11656 1032480000541 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1032480000542 Proline racemase; Region: Pro_racemase; pfam05544 1032480000543 ornithine cyclodeaminase; Validated; Region: PRK08618 1032480000544 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480000545 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1032480000546 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480000547 DNA-binding site [nucleotide binding]; DNA binding site 1032480000548 UTRA domain; Region: UTRA; cl01230 1032480000549 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1032480000550 active site 1032480000551 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1032480000552 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480000553 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1032480000554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1032480000555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480000556 dimer interface [polypeptide binding]; other site 1032480000557 conserved gate region; other site 1032480000558 putative PBP binding loops; other site 1032480000559 ABC-ATPase subunit interface; other site 1032480000560 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480000561 ABC transporter signature motif; other site 1032480000562 Walker B; other site 1032480000563 D-loop; other site 1032480000564 H-loop/switch region; other site 1032480000565 TOBE domain; Region: TOBE_2; cl01440 1032480000566 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480000567 Walker A/P-loop; other site 1032480000568 ATP binding site [chemical binding]; other site 1032480000569 Q-loop/lid; other site 1032480000570 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480000571 non-specific DNA binding site [nucleotide binding]; other site 1032480000572 salt bridge; other site 1032480000573 sequence-specific DNA binding site [nucleotide binding]; other site 1032480000574 HipA N-terminal domain; Region: Couple_hipA; cl11853 1032480000575 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 1032480000576 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1032480000577 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1032480000578 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 1032480000579 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1032480000580 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1032480000581 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1032480000582 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 1032480000583 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480000584 BNR repeat-like domain; Region: BNR_2; pfam13088 1032480000585 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1032480000586 Moco binding site; other site 1032480000587 metal coordination site [ion binding]; other site 1032480000588 threonine dehydratase; Validated; Region: PRK08639 1032480000589 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1032480000590 tetramer interface [polypeptide binding]; other site 1032480000591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480000592 catalytic residue [active] 1032480000593 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1032480000594 putative Ile/Val binding site [chemical binding]; other site 1032480000595 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480000596 DNA binding residues [nucleotide binding] 1032480000597 dimerization interface [polypeptide binding]; other site 1032480000598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480000599 active site 1032480000600 phosphorylation site [posttranslational modification] 1032480000601 intermolecular recognition site; other site 1032480000602 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 1032480000603 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480000604 ATP binding site [chemical binding]; other site 1032480000605 Mg2+ binding site [ion binding]; other site 1032480000606 G-X-G motif; other site 1032480000607 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1032480000608 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480000609 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1032480000610 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480000611 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1032480000612 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480000613 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1032480000614 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 1032480000615 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1032480000616 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 1032480000617 Walker A/P-loop; other site 1032480000618 ATP binding site [chemical binding]; other site 1032480000619 Q-loop/lid; other site 1032480000620 ABC transporter signature motif; other site 1032480000621 Walker B; other site 1032480000622 D-loop; other site 1032480000623 H-loop/switch region; other site 1032480000624 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1032480000625 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1032480000626 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480000627 Walker A/P-loop; other site 1032480000628 ATP binding site [chemical binding]; other site 1032480000629 Q-loop/lid; other site 1032480000630 ABC transporter signature motif; other site 1032480000631 Walker B; other site 1032480000632 D-loop; other site 1032480000633 H-loop/switch region; other site 1032480000634 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480000635 Helix-turn-helix domains; Region: HTH; cl00088 1032480000636 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480000637 S-adenosylmethionine binding site [chemical binding]; other site 1032480000638 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1032480000639 putative phosphatase; Provisional; Region: PRK11587 1032480000640 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1032480000641 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1032480000642 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1032480000643 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1032480000644 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1032480000645 dimer interface [polypeptide binding]; other site 1032480000646 active site 1032480000647 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1032480000648 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1032480000649 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1032480000650 Walker A/P-loop; other site 1032480000651 ATP binding site [chemical binding]; other site 1032480000652 Q-loop/lid; other site 1032480000653 ABC transporter signature motif; other site 1032480000654 Walker B; other site 1032480000655 D-loop; other site 1032480000656 H-loop/switch region; other site 1032480000657 FtsX-like permease family; Region: FtsX; cl15850 1032480000658 H+ Antiporter protein; Region: 2A0121; TIGR00900 1032480000659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480000660 putative substrate translocation pore; other site 1032480000661 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1032480000662 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 1032480000663 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480000664 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480000665 catalytic residue [active] 1032480000666 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1032480000667 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1032480000668 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1032480000669 active site 1032480000670 peptide synthase; Provisional; Region: PRK12316 1032480000671 AMP-binding enzyme; Region: AMP-binding; cl15778 1032480000672 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1032480000673 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1032480000674 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1032480000675 active site 1032480000676 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1032480000677 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1032480000678 peptide synthase; Provisional; Region: PRK12467 1032480000679 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1032480000680 AMP-binding enzyme; Region: AMP-binding; cl15778 1032480000681 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1032480000682 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1032480000683 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1032480000684 active site 1032480000685 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1032480000686 peptide synthase; Provisional; Region: PRK12467 1032480000687 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1032480000688 AMP-binding enzyme; Region: AMP-binding; cl15778 1032480000689 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1032480000690 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1032480000691 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1032480000692 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1032480000693 Helix-turn-helix domains; Region: HTH; cl00088 1032480000694 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1032480000695 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1032480000696 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1032480000697 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 1032480000698 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 1032480000699 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1032480000700 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 1032480000701 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1032480000702 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1032480000703 dimer interface [polypeptide binding]; other site 1032480000704 putative anticodon binding site; other site 1032480000705 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 1032480000706 motif 1; other site 1032480000707 dimer interface [polypeptide binding]; other site 1032480000708 active site 1032480000709 motif 2; other site 1032480000710 motif 3; other site 1032480000711 Helix-turn-helix domains; Region: HTH; cl00088 1032480000712 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1032480000713 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1032480000714 conserved cys residue [active] 1032480000715 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1032480000716 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 1032480000717 putative NAD(P) binding site [chemical binding]; other site 1032480000718 catalytic Zn binding site [ion binding]; other site 1032480000719 structural Zn binding site [ion binding]; other site 1032480000720 YibE/F-like protein; Region: YibE_F; cl02259 1032480000721 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1032480000722 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1032480000723 minor groove reading motif; other site 1032480000724 helix-hairpin-helix signature motif; other site 1032480000725 active site 1032480000726 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1032480000727 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1032480000728 dimerization interface [polypeptide binding]; other site 1032480000729 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1032480000730 dimer interface [polypeptide binding]; other site 1032480000731 phosphorylation site [posttranslational modification] 1032480000732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480000733 ATP binding site [chemical binding]; other site 1032480000734 Mg2+ binding site [ion binding]; other site 1032480000735 G-X-G motif; other site 1032480000736 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1032480000737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480000738 active site 1032480000739 phosphorylation site [posttranslational modification] 1032480000740 intermolecular recognition site; other site 1032480000741 dimerization interface [polypeptide binding]; other site 1032480000742 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1032480000743 DNA binding site [nucleotide binding] 1032480000744 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480000745 Helix-turn-helix domains; Region: HTH; cl00088 1032480000746 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1032480000747 ATP synthase I chain; Region: ATP_synt_I; cl09170 1032480000748 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480000749 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 1032480000750 Walker A/P-loop; other site 1032480000751 Walker A/P-loop; other site 1032480000752 ATP binding site [chemical binding]; other site 1032480000753 ATP binding site [chemical binding]; other site 1032480000754 Q-loop/lid; other site 1032480000755 ABC transporter signature motif; other site 1032480000756 Walker B; other site 1032480000757 D-loop; other site 1032480000758 H-loop/switch region; other site 1032480000759 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1032480000760 Predicted membrane protein [Function unknown]; Region: COG1511 1032480000761 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1032480000762 Capsid protein (F protein); Region: Phage_F; cl15846 1032480000763 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1032480000764 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480000765 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1032480000766 active site 1032480000767 metal binding site [ion binding]; metal-binding site 1032480000768 CAAX protease self-immunity; Region: Abi; cl00558 1032480000769 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1032480000770 Ferritin-like domain; Region: Ferritin; pfam00210 1032480000771 ferroxidase diiron center [ion binding]; other site 1032480000772 Helix-turn-helix domains; Region: HTH; cl00088 1032480000773 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1032480000774 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1032480000775 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480000776 NAD(P) binding site [chemical binding]; other site 1032480000777 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1032480000778 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 1032480000779 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1032480000780 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1032480000781 active site 1032480000782 Membrane protein of unknown function; Region: DUF360; cl00850 1032480000783 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1032480000784 mycothiol-dependent formaldehyde dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1032480000785 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1032480000786 NAD binding site [chemical binding]; other site 1032480000787 catalytic Zn binding site [ion binding]; other site 1032480000788 substrate binding site [chemical binding]; other site 1032480000789 structural Zn binding site [ion binding]; other site 1032480000790 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1032480000791 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1032480000792 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480000793 Walker A/P-loop; other site 1032480000794 ATP binding site [chemical binding]; other site 1032480000795 Q-loop/lid; other site 1032480000796 ABC transporter signature motif; other site 1032480000797 Walker B; other site 1032480000798 D-loop; other site 1032480000799 H-loop/switch region; other site 1032480000800 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1032480000801 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1032480000802 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480000803 Walker A/P-loop; other site 1032480000804 ATP binding site [chemical binding]; other site 1032480000805 Q-loop/lid; other site 1032480000806 ABC transporter signature motif; other site 1032480000807 Walker B; other site 1032480000808 D-loop; other site 1032480000809 H-loop/switch region; other site 1032480000810 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480000811 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 1032480000812 CobD/Cbib protein; Region: CobD_Cbib; cl00561 1032480000813 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1032480000814 homotrimer interface [polypeptide binding]; other site 1032480000815 Walker A motif; other site 1032480000816 GTP binding site [chemical binding]; other site 1032480000817 Walker B motif; other site 1032480000818 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1032480000819 Helix-turn-helix domains; Region: HTH; cl00088 1032480000820 Helix-turn-helix domains; Region: HTH; cl00088 1032480000821 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1032480000822 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1032480000823 tandem repeat interface [polypeptide binding]; other site 1032480000824 oligomer interface [polypeptide binding]; other site 1032480000825 active site residues [active] 1032480000826 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1032480000827 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1032480000828 oligomer interface [polypeptide binding]; other site 1032480000829 tandem repeat interface [polypeptide binding]; other site 1032480000830 active site residues [active] 1032480000831 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 1032480000832 nudix motif; other site 1032480000833 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 1032480000834 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1032480000835 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1032480000836 putative dimer interface [polypeptide binding]; other site 1032480000837 active site pocket [active] 1032480000838 putative cataytic base [active] 1032480000839 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 1032480000840 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480000841 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 1032480000842 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1032480000843 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1032480000844 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1032480000845 catalytic triad [active] 1032480000846 hypothetical protein; Provisional; Region: PRK07908 1032480000847 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480000848 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480000849 homodimer interface [polypeptide binding]; other site 1032480000850 catalytic residue [active] 1032480000851 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1032480000852 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1032480000853 homodimer interface [polypeptide binding]; other site 1032480000854 Walker A motif; other site 1032480000855 ATP binding site [chemical binding]; other site 1032480000856 hydroxycobalamin binding site [chemical binding]; other site 1032480000857 Walker B motif; other site 1032480000858 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1032480000859 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480000860 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 1032480000861 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1032480000862 metal ion-dependent adhesion site (MIDAS); other site 1032480000863 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 1032480000864 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1032480000865 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 1032480000866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480000867 S-adenosylmethionine binding site [chemical binding]; other site 1032480000868 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 1032480000869 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1032480000870 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 1032480000871 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1032480000872 substrate binding site [chemical binding]; other site 1032480000873 dimer interface [polypeptide binding]; other site 1032480000874 catalytic triad [active] 1032480000875 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 1032480000876 dihydroxyacetone kinase; Provisional; Region: PRK14479 1032480000877 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1032480000878 DAK2 domain; Region: Dak2; cl03685 1032480000879 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1032480000880 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480000881 DNA-binding site [nucleotide binding]; DNA binding site 1032480000882 FCD domain; Region: FCD; cl11656 1032480000883 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1032480000884 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480000885 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1032480000886 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1032480000887 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1032480000888 classical (c) SDRs; Region: SDR_c; cd05233 1032480000889 NAD(P) binding site [chemical binding]; other site 1032480000890 active site 1032480000891 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1032480000892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480000893 putative substrate translocation pore; other site 1032480000894 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1032480000895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480000896 NAD(P) binding site [chemical binding]; other site 1032480000897 L-rhamnonate dehydratase; Provisional; Region: PRK15440 1032480000898 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 1032480000899 putative active site pocket [active] 1032480000900 putative metal binding site [ion binding]; other site 1032480000901 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 1032480000902 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1032480000903 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480000904 CCC1-related family of proteins; Region: CCC1_like; cl00278 1032480000905 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1032480000906 putative dimer interface [polypeptide binding]; other site 1032480000907 catalytic triad [active] 1032480000908 Integrase core domain; Region: rve; cl01316 1032480000909 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1032480000910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480000911 Walker A motif; other site 1032480000912 ATP binding site [chemical binding]; other site 1032480000913 Walker B motif; other site 1032480000914 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1032480000915 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 1032480000916 hypothetical protein; Reviewed; Region: PRK09588 1032480000917 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1032480000918 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1032480000919 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480000920 Ligand Binding Site [chemical binding]; other site 1032480000921 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1032480000922 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 1032480000923 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1032480000924 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 1032480000925 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 1032480000926 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1032480000927 precorrin-3B synthase; Region: CobG; TIGR02435 1032480000928 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1032480000929 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1032480000930 catalytic core [active] 1032480000931 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1032480000932 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1032480000933 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1032480000934 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 1032480000935 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 1032480000936 putative NAD(P) binding site [chemical binding]; other site 1032480000937 catalytic Zn binding site [ion binding]; other site 1032480000938 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 1032480000939 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1032480000940 NADP binding site [chemical binding]; other site 1032480000941 homodimer interface [polypeptide binding]; other site 1032480000942 active site 1032480000943 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1032480000944 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480000945 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1032480000946 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 1032480000947 Helix-turn-helix domains; Region: HTH; cl00088 1032480000948 DNA binding site [nucleotide binding] 1032480000949 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1032480000950 NlpC/P60 family; Region: NLPC_P60; cl11438 1032480000951 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 1032480000952 Baseplate J-like protein; Region: Baseplate_J; cl01294 1032480000953 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1032480000954 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1032480000955 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1032480000956 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 1032480000957 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 1032480000958 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 1032480000959 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1032480000960 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1032480000961 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 1032480000962 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1032480000963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480000964 Walker A motif; other site 1032480000965 ATP binding site [chemical binding]; other site 1032480000966 Walker B motif; other site 1032480000967 arginine finger; other site 1032480000968 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 1032480000969 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1032480000970 Cell division protein FtsA; Region: FtsA; cl11496 1032480000971 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 1032480000972 Sporulation related domain; Region: SPOR; cl10051 1032480000973 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1032480000974 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1032480000975 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1032480000976 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480000977 Dynamin family; Region: Dynamin_N; pfam00350 1032480000978 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480000979 G3 box; other site 1032480000980 Switch II region; other site 1032480000981 GTP/Mg2+ binding site [chemical binding]; other site 1032480000982 G4 box; other site 1032480000983 G5 box; other site 1032480000984 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480000985 G1 box; other site 1032480000986 GTP/Mg2+ binding site [chemical binding]; other site 1032480000987 G2 box; other site 1032480000988 Switch I region; other site 1032480000989 G3 box; other site 1032480000990 Switch II region; other site 1032480000991 G4 box; other site 1032480000992 G5 box; other site 1032480000993 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480000994 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480000995 DNA binding residues [nucleotide binding] 1032480000996 dimerization interface [polypeptide binding]; other site 1032480000997 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480000998 Tyrosine kinase, catalytic domain; Region: TyrKc; smart00219 1032480000999 active site 1032480001000 ATP binding site [chemical binding]; other site 1032480001001 substrate binding site [chemical binding]; other site 1032480001002 activation loop (A-loop); other site 1032480001003 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1032480001004 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1032480001005 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1032480001006 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1032480001007 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480001008 S-adenosylmethionine binding site [chemical binding]; other site 1032480001009 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480001010 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231 1032480001011 ATP binding site [chemical binding]; other site 1032480001012 active site 1032480001013 substrate binding site [chemical binding]; other site 1032480001014 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1032480001015 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1032480001016 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 1032480001017 cobyric acid synthase; Provisional; Region: PRK00784 1032480001018 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480001019 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1032480001020 catalytic triad [active] 1032480001021 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1032480001022 active site 1032480001023 NTP binding site [chemical binding]; other site 1032480001024 metal binding triad [ion binding]; metal-binding site 1032480001025 Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706 1032480001026 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480001027 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 1032480001028 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480001029 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480001030 DNA binding residues [nucleotide binding] 1032480001031 dimerization interface [polypeptide binding]; other site 1032480001032 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1032480001033 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1032480001034 active site 1032480001035 TDP-binding site; other site 1032480001036 acceptor substrate-binding pocket; other site 1032480001037 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1032480001038 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1032480001039 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480001040 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 1032480001041 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 1032480001042 EamA-like transporter family; Region: EamA; cl01037 1032480001043 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1032480001044 CGNR zinc finger; Region: zf-CGNR; pfam11706 1032480001045 aspartate aminotransferase; Provisional; Region: PRK05764 1032480001046 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480001047 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480001048 homodimer interface [polypeptide binding]; other site 1032480001049 catalytic residue [active] 1032480001050 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1032480001051 YCII-related domain; Region: YCII; cl00999 1032480001052 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1032480001053 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480001054 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480001055 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 1032480001056 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1032480001057 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1032480001058 active site 1032480001059 NAD binding site [chemical binding]; other site 1032480001060 metal binding site [ion binding]; metal-binding site 1032480001061 AlkA N-terminal domain; Region: AlkA_N; cl05528 1032480001062 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1032480001063 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1032480001064 minor groove reading motif; other site 1032480001065 helix-hairpin-helix signature motif; other site 1032480001066 substrate binding pocket [chemical binding]; other site 1032480001067 active site 1032480001068 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1032480001069 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 1032480001070 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1032480001071 active site clefts [active] 1032480001072 zinc binding site [ion binding]; other site 1032480001073 dimer interface [polypeptide binding]; other site 1032480001074 LssY C-terminus; Region: LssY_C; pfam14067 1032480001075 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1032480001076 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1032480001077 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480001078 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1032480001079 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1032480001080 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1032480001081 active site 1032480001082 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1032480001083 Sulfate transporter family; Region: Sulfate_transp; cl15842 1032480001084 Sulfate transporter family; Region: Sulfate_transp; cl15842 1032480001085 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1032480001086 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1032480001087 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1032480001088 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1032480001089 SCP-2 sterol transfer family; Region: SCP2; cl01225 1032480001090 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1032480001091 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1032480001092 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480001093 DNA binding residues [nucleotide binding] 1032480001094 dimerization interface [polypeptide binding]; other site 1032480001095 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 1032480001096 ATP binding site [chemical binding]; other site 1032480001097 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1032480001098 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1032480001099 TPP-binding site [chemical binding]; other site 1032480001100 heterodimer interface [polypeptide binding]; other site 1032480001101 tetramer interface [polypeptide binding]; other site 1032480001102 phosphorylation loop region [posttranslational modification] 1032480001103 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1032480001104 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1032480001105 alpha subunit interface [polypeptide binding]; other site 1032480001106 TPP binding site [chemical binding]; other site 1032480001107 heterodimer interface [polypeptide binding]; other site 1032480001108 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1032480001109 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1032480001110 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1032480001111 E3 interaction surface; other site 1032480001112 lipoyl attachment site [posttranslational modification]; other site 1032480001113 e3 binding domain; Region: E3_binding; pfam02817 1032480001114 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 1032480001115 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480001116 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480001117 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1032480001118 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480001119 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480001120 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1032480001121 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1032480001122 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480001123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480001124 active site 1032480001125 phosphorylation site [posttranslational modification] 1032480001126 intermolecular recognition site; other site 1032480001127 dimerization interface [polypeptide binding]; other site 1032480001128 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480001129 DNA binding residues [nucleotide binding] 1032480001130 dimerization interface [polypeptide binding]; other site 1032480001131 Histidine kinase; Region: HisKA_3; pfam07730 1032480001132 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1032480001133 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1032480001134 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1032480001135 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1032480001136 active site 1032480001137 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1032480001138 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1032480001139 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1032480001140 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1032480001141 DinB superfamily; Region: DinB_2; pfam12867 1032480001142 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480001143 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1032480001144 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1032480001145 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1032480001146 putative active site [active] 1032480001147 putative substrate binding site [chemical binding]; other site 1032480001148 putative cosubstrate binding site; other site 1032480001149 catalytic site [active] 1032480001150 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1032480001151 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480001152 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 1032480001153 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1032480001154 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1032480001155 Helix-turn-helix domains; Region: HTH; cl00088 1032480001156 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1032480001157 Divergent AAA domain; Region: AAA_4; pfam04326 1032480001158 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1032480001159 trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455 1032480001160 Helix-turn-helix domains; Region: HTH; cl00088 1032480001161 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1032480001162 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480001163 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1032480001164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480001165 putative substrate translocation pore; other site 1032480001166 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1032480001167 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1032480001168 putative NAD(P) binding site [chemical binding]; other site 1032480001169 dimer interface [polypeptide binding]; other site 1032480001170 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 1032480001171 Helix-turn-helix domains; Region: HTH; cl00088 1032480001172 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1032480001173 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480001174 Helix-turn-helix domains; Region: HTH; cl00088 1032480001175 DNA binding residues [nucleotide binding] 1032480001176 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1032480001177 Flavin Reductases; Region: FlaRed; cl00801 1032480001178 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1032480001179 hydrophobic ligand binding site; other site 1032480001180 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1032480001181 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1032480001182 inhibitor-cofactor binding pocket; inhibition site 1032480001183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480001184 catalytic residue [active] 1032480001185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480001186 NAD(P) binding site [chemical binding]; other site 1032480001187 active site 1032480001188 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1032480001189 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 1032480001190 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 1032480001191 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1032480001192 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1032480001193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480001194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480001195 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480001196 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1032480001197 active site 1032480001198 metal binding site [ion binding]; metal-binding site 1032480001199 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480001200 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 1032480001201 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480001202 active site 1032480001203 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1032480001204 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 1032480001205 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 1032480001206 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 1032480001207 nucleotide binding site [chemical binding]; other site 1032480001208 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 1032480001209 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1032480001210 active site 1032480001211 DNA binding site [nucleotide binding] 1032480001212 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1032480001213 DNA binding site [nucleotide binding] 1032480001214 DinB superfamily; Region: DinB_2; pfam12867 1032480001215 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1032480001216 nudix motif; other site 1032480001217 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1032480001218 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1032480001219 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1032480001220 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1032480001221 active site 1032480001222 ATP-binding site [chemical binding]; other site 1032480001223 pantoate-binding site; other site 1032480001224 HXXH motif; other site 1032480001225 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1032480001226 oligomerization interface [polypeptide binding]; other site 1032480001227 active site 1032480001228 metal binding site [ion binding]; metal-binding site 1032480001229 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1032480001230 active site 1032480001231 nucleotide binding site [chemical binding]; other site 1032480001232 HIGH motif; other site 1032480001233 KMSKS motif; other site 1032480001234 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1032480001235 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480001236 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480001237 homodimer interface [polypeptide binding]; other site 1032480001238 catalytic residue [active] 1032480001239 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480001240 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480001241 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1032480001242 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1032480001243 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1032480001244 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1032480001245 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1032480001246 active site 1032480001247 DNA binding site [nucleotide binding] 1032480001248 mercuric reductase; Validated; Region: PRK06370 1032480001249 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1032480001250 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1032480001251 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480001252 Helix-turn-helix domains; Region: HTH; cl00088 1032480001253 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1032480001254 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1032480001255 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480001256 active site 1032480001257 catalytic tetrad [active] 1032480001258 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480001259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480001260 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480001261 putative substrate translocation pore; other site 1032480001262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480001263 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1032480001264 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1032480001265 shikimate binding site; other site 1032480001266 NAD(P) binding site [chemical binding]; other site 1032480001267 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480001268 Ligand Binding Site [chemical binding]; other site 1032480001269 Amino acid permease; Region: AA_permease_2; pfam13520 1032480001270 Spore germination protein; Region: Spore_permease; cl15802 1032480001271 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 1032480001272 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 1032480001273 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1032480001274 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1032480001275 active site 1032480001276 dimer interface [polypeptide binding]; other site 1032480001277 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1032480001278 dimer interface [polypeptide binding]; other site 1032480001279 active site 1032480001280 Alkylmercury lyase; Region: MerB; pfam03243 1032480001281 Cupin domain; Region: Cupin_2; cl09118 1032480001282 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480001283 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1032480001284 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480001285 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1032480001286 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1032480001287 active site 1032480001288 motif I; other site 1032480001289 motif II; other site 1032480001290 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1032480001291 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480001292 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480001293 YCII-related domain; Region: YCII; cl00999 1032480001294 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1032480001295 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1032480001296 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1032480001297 catalytic residues [active] 1032480001298 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1032480001299 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480001300 motif II; other site 1032480001301 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1032480001302 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1032480001303 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1032480001304 DNA binding residues [nucleotide binding] 1032480001305 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1032480001306 putative dimer interface [polypeptide binding]; other site 1032480001307 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 1032480001308 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1032480001309 molybdopterin cofactor binding site; other site 1032480001310 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1032480001311 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1032480001312 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1032480001313 molybdopterin cofactor binding site; other site 1032480001314 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1032480001315 hypothetical protein; Validated; Region: PRK09169 1032480001316 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1032480001317 4Fe-4S binding domain; Region: Fer4; cl02805 1032480001318 Polysulphide reductase, NrfD; Region: NrfD; cl01295 1032480001319 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1032480001320 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1032480001321 dimerization interface [polypeptide binding]; other site 1032480001322 putative ATP binding site [chemical binding]; other site 1032480001323 selenocysteine synthase; Provisional; Region: PRK04311 1032480001324 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480001325 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 1032480001326 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1032480001327 G1 box; other site 1032480001328 putative GEF interaction site [polypeptide binding]; other site 1032480001329 GTP/Mg2+ binding site [chemical binding]; other site 1032480001330 Switch I region; other site 1032480001331 G2 box; other site 1032480001332 G3 box; other site 1032480001333 Switch II region; other site 1032480001334 G4 box; other site 1032480001335 G5 box; other site 1032480001336 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1032480001337 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 1032480001338 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1032480001339 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1032480001340 putative active site [active] 1032480001341 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1032480001342 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1032480001343 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1032480001344 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1032480001345 putative DNA binding site [nucleotide binding]; other site 1032480001346 catalytic residue [active] 1032480001347 putative H2TH interface [polypeptide binding]; other site 1032480001348 putative catalytic residues [active] 1032480001349 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1032480001350 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1032480001351 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1032480001352 NodB motif; other site 1032480001353 active site 1032480001354 catalytic site [active] 1032480001355 metal binding site [ion binding]; metal-binding site 1032480001356 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 1032480001357 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1032480001358 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 1032480001359 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1032480001360 active site 1032480001361 HIGH motif; other site 1032480001362 KMSK motif region; other site 1032480001363 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1032480001364 tRNA binding surface [nucleotide binding]; other site 1032480001365 anticodon binding site; other site 1032480001366 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1032480001367 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1032480001368 Predicted membrane protein [Function unknown]; Region: COG3428 1032480001369 Bacterial PH domain; Region: DUF304; cl01348 1032480001370 Bacterial PH domain; Region: DUF304; cl01348 1032480001371 Bacterial PH domain; Region: DUF304; cl01348 1032480001372 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480001373 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480001374 active site 1032480001375 ATP binding site [chemical binding]; other site 1032480001376 substrate binding site [chemical binding]; other site 1032480001377 Bacterial PH domain; Region: DUF304; cl01348 1032480001378 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1032480001379 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1032480001380 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1032480001381 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480001382 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480001383 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1032480001384 active site 1032480001385 metal binding site [ion binding]; metal-binding site 1032480001386 Helix-turn-helix domains; Region: HTH; cl00088 1032480001387 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1032480001388 Predicted ATPase [General function prediction only]; Region: COG3903 1032480001389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480001390 NAD(P) binding site [chemical binding]; other site 1032480001391 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1032480001392 active site 1032480001393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1032480001394 Helix-turn-helix domains; Region: HTH; cl00088 1032480001395 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 1032480001396 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1032480001397 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1032480001398 metal binding site [ion binding]; metal-binding site 1032480001399 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1032480001400 Helix-turn-helix domains; Region: HTH; cl00088 1032480001401 Helix-turn-helix domains; Region: HTH; cl00088 1032480001402 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1032480001403 Helix-turn-helix domains; Region: HTH; cl00088 1032480001404 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1032480001405 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480001406 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1032480001407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480001408 putative substrate translocation pore; other site 1032480001409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480001410 KIAA1161 is an uncharacterized Homo sapiens protein with a glycosyl hydrolase family 31 (GH31) domain that is homologous to the Escherichia coli YihQ glucosidase. Orthologs of KIA1161 are found in eukaryotes and prokaryotes. In bacteria, YihQ (along with...; Region: GH31_glucosidase_KIAA1161; cd06592 1032480001411 putative active site [active] 1032480001412 putative catalytic site [active] 1032480001413 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1032480001414 putative alpha-glucosidase; Provisional; Region: PRK10658 1032480001415 Protein of unknown function DUF111; Region: DUF111; cl03398 1032480001416 AIR carboxylase; Region: AIRC; cl00310 1032480001417 TIGR00268 family protein; Region: TIGR00268 1032480001418 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 1032480001419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480001420 putative transporter; Provisional; Region: PRK10504 1032480001421 putative substrate translocation pore; other site 1032480001422 altronate oxidoreductase; Provisional; Region: PRK03643 1032480001423 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1032480001424 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1032480001425 Glucuronate isomerase; Region: UxaC; cl00829 1032480001426 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480001427 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480001428 DNA binding site [nucleotide binding] 1032480001429 domain linker motif; other site 1032480001430 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480001431 dimerization interface [polypeptide binding]; other site 1032480001432 ligand binding site [chemical binding]; other site 1032480001433 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1032480001434 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480001435 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480001436 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1032480001437 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1032480001438 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1032480001439 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1032480001440 MOSC domain; Region: MOSC; pfam03473 1032480001441 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1032480001442 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480001443 active site 1032480001444 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1032480001445 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1032480001446 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1032480001447 FAD binding pocket [chemical binding]; other site 1032480001448 FAD binding motif [chemical binding]; other site 1032480001449 phosphate binding motif [ion binding]; other site 1032480001450 NAD binding pocket [chemical binding]; other site 1032480001451 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 1032480001452 phosphopeptide binding site; other site 1032480001453 RDD family; Region: RDD; cl00746 1032480001454 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 1032480001455 phosphopeptide binding site; other site 1032480001456 2'-deoxycytidine 5'-triphosphate deaminase (DCD); Region: DCD; pfam06559 1032480001457 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1032480001458 trimer interface [polypeptide binding]; other site 1032480001459 active site 1032480001460 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1032480001461 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1032480001462 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1032480001463 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1032480001464 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 1032480001465 Walker A/P-loop; other site 1032480001466 ATP binding site [chemical binding]; other site 1032480001467 Q-loop/lid; other site 1032480001468 ABC transporter signature motif; other site 1032480001469 Walker B; other site 1032480001470 D-loop; other site 1032480001471 H-loop/switch region; other site 1032480001472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1032480001473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1032480001474 NMT1-like family; Region: NMT1_2; cl15260 1032480001475 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1032480001476 Helix-turn-helix domain; Region: HTH_18; pfam12833 1032480001477 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1032480001478 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480001479 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480001480 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480001481 active site 1032480001482 ATP binding site [chemical binding]; other site 1032480001483 substrate binding site [chemical binding]; other site 1032480001484 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1032480001485 active site 1032480001486 NTP binding site [chemical binding]; other site 1032480001487 metal binding triad [ion binding]; metal-binding site 1032480001488 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1032480001489 nucleotide binding site [chemical binding]; other site 1032480001490 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1032480001491 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1032480001492 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480001493 Walker A/P-loop; other site 1032480001494 ATP binding site [chemical binding]; other site 1032480001495 Q-loop/lid; other site 1032480001496 ABC transporter signature motif; other site 1032480001497 Walker B; other site 1032480001498 D-loop; other site 1032480001499 H-loop/switch region; other site 1032480001500 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1032480001501 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1032480001502 active site pocket [active] 1032480001503 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1032480001504 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1032480001505 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1032480001506 dimer interface [polypeptide binding]; other site 1032480001507 phosphorylation site [posttranslational modification] 1032480001508 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480001509 ATP binding site [chemical binding]; other site 1032480001510 Mg2+ binding site [ion binding]; other site 1032480001511 G-X-G motif; other site 1032480001512 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1032480001513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480001514 active site 1032480001515 phosphorylation site [posttranslational modification] 1032480001516 intermolecular recognition site; other site 1032480001517 dimerization interface [polypeptide binding]; other site 1032480001518 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1032480001519 DNA binding site [nucleotide binding] 1032480001520 DoxX; Region: DoxX; cl00976 1032480001521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1032480001522 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1032480001523 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1032480001524 dimer interface [polypeptide binding]; other site 1032480001525 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480001526 dimerization interface [polypeptide binding]; other site 1032480001527 putative DNA binding site [nucleotide binding]; other site 1032480001528 putative Zn2+ binding site [ion binding]; other site 1032480001529 H+ Antiporter protein; Region: 2A0121; TIGR00900 1032480001530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480001531 putative acetyltransferase; Provisional; Region: PRK03624 1032480001532 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480001533 Coenzyme A binding pocket [chemical binding]; other site 1032480001534 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 1032480001535 extended (e) SDRs; Region: SDR_e; cd08946 1032480001536 NAD(P) binding site [chemical binding]; other site 1032480001537 active site 1032480001538 substrate binding site [chemical binding]; other site 1032480001539 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1032480001540 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 1032480001541 ATP binding site [chemical binding]; other site 1032480001542 profilin binding site; other site 1032480001543 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1032480001544 dimer interface [polypeptide binding]; other site 1032480001545 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1032480001546 chaperone protein DnaJ; Provisional; Region: PRK14295 1032480001547 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1032480001548 HSP70 interaction site [polypeptide binding]; other site 1032480001549 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1032480001550 Zn binding sites [ion binding]; other site 1032480001551 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1032480001552 dimer interface [polypeptide binding]; other site 1032480001553 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1032480001554 DNA binding residues [nucleotide binding] 1032480001555 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1032480001556 putative dimer interface [polypeptide binding]; other site 1032480001557 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 1032480001558 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1032480001559 Clp amino terminal domain; Region: Clp_N; pfam02861 1032480001560 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480001561 Walker A motif; other site 1032480001562 ATP binding site [chemical binding]; other site 1032480001563 Walker B motif; other site 1032480001564 arginine finger; other site 1032480001565 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480001566 Walker A motif; other site 1032480001567 ATP binding site [chemical binding]; other site 1032480001568 Walker B motif; other site 1032480001569 arginine finger; other site 1032480001570 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1032480001571 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1032480001572 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480001573 dimer interface [polypeptide binding]; other site 1032480001574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 1032480001575 CAAX protease self-immunity; Region: Abi; cl00558 1032480001576 imidazolonepropionase; Provisional; Region: PRK14085 1032480001577 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1032480001578 active site 1032480001579 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1032480001580 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1032480001581 active site 1032480001582 allantoate amidohydrolase; Reviewed; Region: PRK09290 1032480001583 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1032480001584 active site 1032480001585 metal binding site [ion binding]; metal-binding site 1032480001586 dimer interface [polypeptide binding]; other site 1032480001587 urocanate hydratase; Provisional; Region: PRK05414 1032480001588 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1032480001589 active sites [active] 1032480001590 tetramer interface [polypeptide binding]; other site 1032480001591 Helix-turn-helix domains; Region: HTH; cl00088 1032480001592 Bacterial transcriptional regulator; Region: IclR; pfam01614 1032480001593 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1032480001594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480001595 putative substrate translocation pore; other site 1032480001596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480001597 aminotransferase; Validated; Region: PRK07777 1032480001598 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480001599 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480001600 homodimer interface [polypeptide binding]; other site 1032480001601 catalytic residue [active] 1032480001602 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1032480001603 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 1032480001604 active site 1032480001605 catalytic site [active] 1032480001606 Domain of unknown function DUF87; Region: DUF87; pfam01935 1032480001607 AAA-like domain; Region: AAA_10; pfam12846 1032480001608 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 1032480001609 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1032480001610 active site 1032480001611 LemA family; Region: LemA; cl00742 1032480001612 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1032480001613 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480001614 active site 1032480001615 catalytic tetrad [active] 1032480001616 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1032480001617 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1032480001618 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1032480001619 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1032480001620 Rv0623-like transcription factor; Region: PSK_trans_fac; cl01834 1032480001621 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1032480001622 putative active site [active] 1032480001623 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1032480001624 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1032480001625 active site 1032480001626 catalytic site [active] 1032480001627 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 1032480001628 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 1032480001629 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1032480001630 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1032480001631 Ca binding site [ion binding]; other site 1032480001632 active site 1032480001633 catalytic site [active] 1032480001634 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 1032480001635 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1032480001636 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480001637 DNA-binding site [nucleotide binding]; DNA binding site 1032480001638 FCD domain; Region: FCD; cl11656 1032480001639 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1032480001640 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1032480001641 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1032480001642 substrate binding pocket [chemical binding]; other site 1032480001643 membrane-bound complex binding site; other site 1032480001644 hinge residues; other site 1032480001645 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 1032480001646 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1032480001647 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1032480001648 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1032480001649 metal binding triad; other site 1032480001650 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1032480001651 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480001652 DNA-binding site [nucleotide binding]; DNA binding site 1032480001653 UTRA domain; Region: UTRA; cl01230 1032480001654 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1032480001655 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480001656 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480001657 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480001658 DNA binding site [nucleotide binding] 1032480001659 domain linker motif; other site 1032480001660 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1032480001661 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1032480001662 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1032480001663 active site 1032480001664 intersubunit interface [polypeptide binding]; other site 1032480001665 zinc binding site [ion binding]; other site 1032480001666 Na+ binding site [ion binding]; other site 1032480001667 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1032480001668 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 1032480001669 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1032480001670 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1032480001671 Uncharacterized conserved protein (DUF2293); Region: DUF2293; cl02373 1032480001672 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1032480001673 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480001674 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1032480001675 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1032480001676 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1032480001677 GDP-binding site [chemical binding]; other site 1032480001678 ACT binding site; other site 1032480001679 IMP binding site; other site 1032480001680 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480001681 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480001682 DNA binding site [nucleotide binding] 1032480001683 domain linker motif; other site 1032480001684 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1032480001685 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 1032480001686 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1032480001687 substrate binding [chemical binding]; other site 1032480001688 active site 1032480001689 Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251 1032480001690 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1032480001691 substrate binding [chemical binding]; other site 1032480001692 active site 1032480001693 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1032480001694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480001695 dimer interface [polypeptide binding]; other site 1032480001696 conserved gate region; other site 1032480001697 putative PBP binding loops; other site 1032480001698 ABC-ATPase subunit interface; other site 1032480001699 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1032480001700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480001701 putative PBP binding loops; other site 1032480001702 dimer interface [polypeptide binding]; other site 1032480001703 ABC-ATPase subunit interface; other site 1032480001704 potential frameshift: common BLAST hit: gi|229819326|ref|YP_002880852.1| extracellular solute-binding protein family 1 1032480001705 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480001706 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480001707 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1032480001708 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1032480001709 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1032480001710 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1032480001711 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1032480001712 tetramer interface [polypeptide binding]; other site 1032480001713 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1032480001714 classical (c) SDRs; Region: SDR_c; cd05233 1032480001715 NAD(P) binding site [chemical binding]; other site 1032480001716 active site 1032480001717 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1032480001718 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1032480001719 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1032480001720 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480001721 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1032480001722 Walker A/P-loop; other site 1032480001723 ATP binding site [chemical binding]; other site 1032480001724 Q-loop/lid; other site 1032480001725 ABC transporter signature motif; other site 1032480001726 Walker B; other site 1032480001727 D-loop; other site 1032480001728 H-loop/switch region; other site 1032480001729 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1032480001730 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480001731 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480001732 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480001733 PspC domain; Region: PspC; cl00864 1032480001734 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1032480001735 ATP binding site [chemical binding]; other site 1032480001736 active site 1032480001737 substrate binding site [chemical binding]; other site 1032480001738 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 1032480001739 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1032480001740 putative active site [active] 1032480001741 catalytic triad [active] 1032480001742 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1032480001743 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1032480001744 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1032480001745 dimerization interface [polypeptide binding]; other site 1032480001746 ATP binding site [chemical binding]; other site 1032480001747 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1032480001748 dimerization interface [polypeptide binding]; other site 1032480001749 ATP binding site [chemical binding]; other site 1032480001750 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1032480001751 putative active site [active] 1032480001752 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 1032480001753 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1032480001754 active site 1032480001755 metal binding site [ion binding]; metal-binding site 1032480001756 dimer interface [polypeptide binding]; other site 1032480001757 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 1032480001758 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1032480001759 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1032480001760 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1032480001761 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1032480001762 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1032480001763 active site 1032480001764 tetramer interface [polypeptide binding]; other site 1032480001765 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1032480001766 active site 1032480001767 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1032480001768 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1032480001769 dimerization interface [polypeptide binding]; other site 1032480001770 putative ATP binding site [chemical binding]; other site 1032480001771 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1032480001772 Tic20-like protein; Region: Tic20; pfam09685 1032480001773 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1032480001774 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480001775 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1032480001776 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480001777 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1032480001778 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480001779 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480001780 DNA binding site [nucleotide binding] 1032480001781 domain linker motif; other site 1032480001782 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480001783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480001784 putative substrate translocation pore; other site 1032480001785 Probable beta-xylosidase; Provisional; Region: PLN03080 1032480001786 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1032480001787 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1032480001788 Fibronectin type III-like domain; Region: Fn3-like; cl15273 1032480001789 Survival protein SurE; Region: SurE; cl00448 1032480001790 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480001791 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480001792 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480001793 domain linker motif; other site 1032480001794 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1032480001795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1032480001796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480001797 dimer interface [polypeptide binding]; other site 1032480001798 conserved gate region; other site 1032480001799 putative PBP binding loops; other site 1032480001800 ABC-ATPase subunit interface; other site 1032480001801 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1032480001802 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 1032480001803 Right handed beta helix region; Region: Beta_helix; pfam13229 1032480001804 Helix-turn-helix domains; Region: HTH; cl00088 1032480001805 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1032480001806 putative hydrophobic ligand binding site [chemical binding]; other site 1032480001807 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1032480001808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480001809 NAD(P) binding site [chemical binding]; other site 1032480001810 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1032480001811 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480001812 DNA-binding site [nucleotide binding]; DNA binding site 1032480001813 UTRA domain; Region: UTRA; cl01230 1032480001814 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 1032480001815 N- and C-terminal domain interface [polypeptide binding]; other site 1032480001816 active site 1032480001817 MgATP binding site [chemical binding]; other site 1032480001818 catalytic site [active] 1032480001819 metal binding site [ion binding]; metal-binding site 1032480001820 carbohydrate binding site [chemical binding]; other site 1032480001821 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 1032480001822 N- and C-terminal domain interface [polypeptide binding]; other site 1032480001823 D-xylulose kinase; Region: XylB; TIGR01312 1032480001824 active site 1032480001825 MgATP binding site [chemical binding]; other site 1032480001826 catalytic site [active] 1032480001827 metal binding site [ion binding]; metal-binding site 1032480001828 carbohydrate binding site [chemical binding]; other site 1032480001829 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 1032480001830 N- and C-terminal domain interface [polypeptide binding]; other site 1032480001831 D-xylulose kinase; Region: XylB; TIGR01312 1032480001832 active site 1032480001833 MgATP binding site [chemical binding]; other site 1032480001834 catalytic site [active] 1032480001835 metal binding site [ion binding]; metal-binding site 1032480001836 carbohydrate binding site [chemical binding]; other site 1032480001837 hypothetical protein; Provisional; Region: PRK08185 1032480001838 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1032480001839 intersubunit interface [polypeptide binding]; other site 1032480001840 active site 1032480001841 zinc binding site [ion binding]; other site 1032480001842 Na+ binding site [ion binding]; other site 1032480001843 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1032480001844 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480001845 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1032480001846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480001847 dimer interface [polypeptide binding]; other site 1032480001848 conserved gate region; other site 1032480001849 putative PBP binding loops; other site 1032480001850 ABC-ATPase subunit interface; other site 1032480001851 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1032480001852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480001853 dimer interface [polypeptide binding]; other site 1032480001854 conserved gate region; other site 1032480001855 putative PBP binding loops; other site 1032480001856 ABC-ATPase subunit interface; other site 1032480001857 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480001858 Helix-turn-helix domains; Region: HTH; cl00088 1032480001859 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1032480001860 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1032480001861 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1032480001862 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1032480001863 lipoyl-biotinyl attachment site [posttranslational modification]; other site 1032480001864 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1032480001865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480001866 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480001867 putative substrate translocation pore; other site 1032480001868 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 1032480001869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480001870 putative substrate translocation pore; other site 1032480001871 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 1032480001872 Helix-turn-helix domains; Region: HTH; cl00088 1032480001873 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1032480001874 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480001875 Bacterial SH3 domain; Region: SH3_3; cl02551 1032480001876 Bacterial SH3 domain; Region: SH3_3; cl02551 1032480001877 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 1032480001878 Bacterial SH3 domain; Region: SH3_3; cl02551 1032480001879 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 1032480001880 Domain of unknown function (DUF202); Region: DUF202; cl09954 1032480001881 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1032480001882 EamA-like transporter family; Region: EamA; cl01037 1032480001883 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 1032480001884 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 1032480001885 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1032480001886 DNA binding site [nucleotide binding] 1032480001887 Int/Topo IB signature motif; other site 1032480001888 active site 1032480001889 putative transposase OrfB; Reviewed; Region: PHA02517 1032480001890 HTH-like domain; Region: HTH_21; pfam13276 1032480001891 Integrase core domain; Region: rve; cl01316 1032480001892 Integrase core domain; Region: rve_3; cl15866 1032480001893 Helix-turn-helix domains; Region: HTH; cl00088 1032480001894 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1032480001895 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480001896 DNA-binding site [nucleotide binding]; DNA binding site 1032480001897 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1032480001898 nudix motif; other site 1032480001899 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1032480001900 nudix motif; other site 1032480001901 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1032480001902 Protein of unknown function (DUF433); Region: DUF433; cl01030 1032480001903 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1032480001904 metal ion-dependent adhesion site (MIDAS); other site 1032480001905 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1032480001906 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480001907 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480001908 catalytic residue [active] 1032480001909 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1032480001910 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1032480001911 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1032480001912 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480001913 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480001914 active site 1032480001915 catalytic tetrad [active] 1032480001916 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 1032480001917 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 1032480001918 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1032480001919 putative active site pocket [active] 1032480001920 metal binding site [ion binding]; metal-binding site 1032480001921 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1032480001922 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480001923 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1032480001924 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain; Region: MR_MLE_N; pfam02746 1032480001925 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1032480001926 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1032480001927 Enolase C-terminal domain-like; Region: MR_MLE_C; pfam13378 1032480001928 Helix-turn-helix domains; Region: HTH; cl00088 1032480001929 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873 1032480001930 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480001931 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1032480001932 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1032480001933 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1032480001934 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1032480001935 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1032480001936 UbiA prenyltransferase family; Region: UbiA; cl00337 1032480001937 AMP-binding enzyme; Region: AMP-binding; cl15778 1032480001938 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 1032480001939 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1032480001940 Enolase C-terminal domain-like; Region: MR_MLE_C; pfam13378 1032480001941 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 1032480001942 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1032480001943 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1032480001944 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1032480001945 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1032480001946 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480001947 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1032480001948 catabolite control protein A; Region: ccpA; TIGR01481 1032480001949 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480001950 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1032480001951 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480001952 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1032480001953 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1032480001954 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1032480001955 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1032480001956 Fibronectin type III-like domain; Region: Fn3-like; cl15273 1032480001957 B3/4 domain; Region: B3_4; cl11458 1032480001958 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480001959 Cupin domain; Region: Cupin_2; cl09118 1032480001960 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480001961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 1032480001962 Arginase family; Region: Arginase; cl00306 1032480001963 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1032480001964 Helix-turn-helix domains; Region: HTH; cl00088 1032480001965 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1032480001966 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1032480001967 FAD binding domain; Region: FAD_binding_4; pfam01565 1032480001968 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 1032480001969 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1032480001970 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1032480001971 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480001972 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1032480001973 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 1032480001974 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1032480001975 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1032480001976 active site 1032480001977 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1032480001978 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480001979 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 1032480001980 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 1032480001981 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 1032480001982 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 1032480001983 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 1032480001984 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 1032480001985 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1032480001986 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 1032480001987 SLBB domain; Region: SLBB; pfam10531 1032480001988 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 1032480001989 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1032480001990 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 1032480001991 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 1032480001992 Molybdopterin oxidoreductase; Region: Molybdopterin; pfam00384 1032480001993 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1032480001994 NADH dehydrogenase; Region: NADHdh; cl00469 1032480001995 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 1032480001996 4Fe-4S binding domain; Region: Fer4; cl02805 1032480001997 4Fe-4S binding domain; Region: Fer4; cl02805 1032480001998 NADH-ubiquinone/plastoquinone oxidoreductase chain 6; Region: Oxidored_q3; pfam00499 1032480001999 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1032480002000 proton-translocating NADH-quinone oxidoreductase, chain L; Region: NDH_I_L; TIGR01974 1032480002001 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1032480002002 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 1032480002003 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 1032480002004 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 1032480002005 proton-translocating NADH-quinone oxidoreductase, chain N; Region: NDH_I_N; TIGR01770 1032480002006 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 1032480002007 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1032480002008 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 1032480002009 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 1032480002010 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480002011 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1032480002012 Helix-turn-helix domains; Region: HTH; cl00088 1032480002013 catalase/peroxidase HPI; Region: cat_per_HPI; TIGR00198 1032480002014 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1032480002015 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1032480002016 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1032480002017 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1032480002018 Peptidase family M13; Region: Peptidase_M13_N; pfam05649 1032480002019 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1032480002020 rarD protein; Region: rarD; TIGR00688 1032480002021 EamA-like transporter family; Region: EamA; cl01037 1032480002022 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1032480002023 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1032480002024 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 1032480002025 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1032480002026 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1032480002027 Helix-turn-helix domains; Region: HTH; cl00088 1032480002028 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1032480002029 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 1032480002030 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1032480002031 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1032480002032 D-xylulose kinase; Region: XylB; TIGR01312 1032480002033 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 1032480002034 Protein of unknown function (DUF805); Region: DUF805; cl01224 1032480002035 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1032480002036 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cl01497 1032480002037 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1032480002038 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480002039 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480002040 Protein of unknown function (DUF520); Region: DUF520; cl00723 1032480002041 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 1032480002042 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 1032480002043 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480002044 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 1032480002045 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 1032480002046 amidohydrolase; Region: amidohydrolases; TIGR01891 1032480002047 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1032480002048 Helix-turn-helix domains; Region: HTH; cl00088 1032480002049 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480002050 Helix-turn-helix domains; Region: HTH; cl00088 1032480002051 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 1032480002052 Helix-turn-helix domains; Region: HTH; cl00088 1032480002053 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 1032480002054 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 1032480002055 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1032480002056 Maltose acetyltransferase; Region: Mac; pfam12464 1032480002057 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1032480002058 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1032480002059 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1032480002060 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480002061 AAA domain; Region: AAA_22; pfam13401 1032480002062 FG-GAP repeat; Region: FG-GAP; cl15299 1032480002063 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1032480002064 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1032480002065 Response regulator receiver domain; Region: Response_reg; pfam00072 1032480002066 Helix-turn-helix domains; Region: HTH; cl00088 1032480002067 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1032480002068 AMP-binding enzyme; Region: AMP-binding; cl15778 1032480002069 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1032480002070 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1032480002071 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1032480002072 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1032480002073 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1032480002074 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1032480002075 AMP-binding enzyme; Region: AMP-binding; cl15778 1032480002076 AMP-binding enzyme; Region: AMP-binding; cl15778 1032480002077 Amidase; Region: Amidase; cl11426 1032480002078 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1032480002079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480002080 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1032480002081 H+ Antiporter protein; Region: 2A0121; TIGR00900 1032480002082 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1032480002083 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 1032480002084 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1032480002085 Amidase; Region: Amidase; cl11426 1032480002086 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 1032480002087 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1032480002088 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_5; cd11352 1032480002089 active site 1032480002090 catalytic site [active] 1032480002091 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1032480002092 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 1032480002093 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1032480002094 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 1032480002095 TIR domain; Region: TIR_2; cl15770 1032480002096 Response regulator receiver domain; Region: Response_reg; pfam00072 1032480002097 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1032480002098 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 1032480002099 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1032480002100 Cupin domain; Region: Cupin_2; cl09118 1032480002101 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 1032480002102 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480002103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480002104 potential frameshift: common BLAST hit: gi|258652603|ref|YP_003201759.1| LuxR family transcriptional regulator 1032480002105 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1032480002106 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480002107 Helix-turn-helix domains; Region: HTH; cl00088 1032480002108 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480002109 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480002110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480002111 Helix-turn-helix domains; Region: HTH; cl00088 1032480002112 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480002113 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1032480002114 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1032480002115 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1032480002116 Fibronectin type III-like domain; Region: Fn3-like; cl15273 1032480002117 FRG domain; Region: FRG; cl07460 1032480002118 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 1032480002119 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480002120 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1032480002121 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1032480002122 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1032480002123 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480002124 Cyclophilin-like; Region: Cyclophil_like; cl00950 1032480002125 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 1032480002126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480002127 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1032480002128 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480002129 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480002130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 1032480002131 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1032480002132 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480002133 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480002134 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1032480002135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 1032480002136 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1032480002137 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480002138 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480002139 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480002140 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480002141 ApbE family; Region: ApbE; cl00643 1032480002142 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1032480002143 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480002144 Oxidoreductase FAD-binding domain; Region: FAD_binding_6; cl03043 1032480002145 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1032480002146 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1032480002147 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1032480002148 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; cl15759 1032480002149 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1032480002150 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1032480002151 Helix-turn-helix domain; Region: HTH_18; pfam12833 1032480002152 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480002153 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1032480002154 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 1032480002155 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1032480002156 Alcohol dehydrogenase GroES-like domain; Region: ADH_N; pfam08240 1032480002157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480002158 Helix-turn-helix domains; Region: HTH; cl00088 1032480002159 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1032480002160 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480002161 CAAX protease self-immunity; Region: Abi; cl00558 1032480002162 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480002163 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1032480002164 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480002165 Alcohol dehydrogenase GroES-associated; Region: ADH_N_assoc; pfam13823 1032480002166 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 1032480002167 Alcohol dehydrogenase GroES-like domain; Region: ADH_N; pfam08240 1032480002168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480002169 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1032480002170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 1032480002171 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480002172 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1032480002173 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480002174 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480002175 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1032480002176 Alcohol dehydrogenase GroES-like domain; Region: ADH_N; pfam08240 1032480002177 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480002178 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1032480002179 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480002180 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1032480002181 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1032480002182 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1032480002183 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480002184 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480002185 DNA binding site [nucleotide binding] 1032480002186 domain linker motif; other site 1032480002187 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480002188 ligand binding site [chemical binding]; other site 1032480002189 dimerization interface [polypeptide binding]; other site 1032480002190 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1032480002191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480002192 dimer interface [polypeptide binding]; other site 1032480002193 conserved gate region; other site 1032480002194 putative PBP binding loops; other site 1032480002195 ABC-ATPase subunit interface; other site 1032480002196 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1032480002197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480002198 dimer interface [polypeptide binding]; other site 1032480002199 conserved gate region; other site 1032480002200 putative PBP binding loops; other site 1032480002201 ABC-ATPase subunit interface; other site 1032480002202 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1032480002203 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480002204 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480002205 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480002206 DNA binding site [nucleotide binding] 1032480002207 domain linker motif; other site 1032480002208 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480002209 dimerization interface [polypeptide binding]; other site 1032480002210 ligand binding site [chemical binding]; other site 1032480002211 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 1032480002212 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 1032480002213 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 1032480002214 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 1032480002215 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1032480002216 Helix-turn-helix domains; Region: HTH; cl00088 1032480002217 putative transposase OrfB; Reviewed; Region: PHA02517 1032480002218 HTH-like domain; Region: HTH_21; pfam13276 1032480002219 Integrase core domain; Region: rve; cl01316 1032480002220 Integrase core domain; Region: rve_3; cl15866 1032480002221 Uncharacterized conserved protein [Function unknown]; Region: COG3347 1032480002222 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1032480002223 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1032480002224 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480002225 NAD(P) binding site [chemical binding]; other site 1032480002226 active site 1032480002227 L-rhamnulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1032480002228 N- and C-terminal domain interface [polypeptide binding]; other site 1032480002229 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 1032480002230 active site 1032480002231 catalytic site [active] 1032480002232 metal binding site [ion binding]; metal-binding site 1032480002233 ATP binding site [chemical binding]; other site 1032480002234 carbohydrate binding site [chemical binding]; other site 1032480002235 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1032480002236 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1032480002237 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1032480002238 active site 1032480002239 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1032480002240 active site 1032480002241 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1032480002242 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1032480002243 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1032480002244 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480002245 Helix-turn-helix domains; Region: HTH; cl00088 1032480002246 hypothetical protein; Provisional; Region: PRK07588 1032480002247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480002248 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1032480002249 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480002250 DNA-binding site [nucleotide binding]; DNA binding site 1032480002251 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480002252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480002253 homodimer interface [polypeptide binding]; other site 1032480002254 catalytic residue [active] 1032480002255 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480002256 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 1032480002257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480002258 S-adenosylmethionine binding site [chemical binding]; other site 1032480002259 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1032480002260 NADP+ binding site [chemical binding]; other site 1032480002261 folate binding site [chemical binding]; other site 1032480002262 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1032480002263 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 1032480002264 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480002265 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 1032480002266 Helix-turn-helix domains; Region: HTH; cl00088 1032480002267 WHG domain; Region: WHG; pfam13305 1032480002268 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 1032480002269 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1032480002270 catalytic Zn binding site [ion binding]; other site 1032480002271 NAD(P) binding site [chemical binding]; other site 1032480002272 structural Zn binding site [ion binding]; other site 1032480002273 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1032480002274 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1032480002275 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1032480002276 Helix-turn-helix domains; Region: HTH; cl00088 1032480002277 Bacterial transcriptional regulator; Region: IclR; pfam01614 1032480002278 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1032480002279 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1032480002280 inhibitor site; inhibition site 1032480002281 active site 1032480002282 dimer interface [polypeptide binding]; other site 1032480002283 catalytic residue [active] 1032480002284 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480002285 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1032480002286 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480002287 DNA-binding site [nucleotide binding]; DNA binding site 1032480002288 FCD domain; Region: FCD; cl11656 1032480002289 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1032480002290 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1032480002291 FAD binding pocket [chemical binding]; other site 1032480002292 FAD binding motif [chemical binding]; other site 1032480002293 phosphate binding motif [ion binding]; other site 1032480002294 beta-alpha-beta structure motif; other site 1032480002295 NAD binding pocket [chemical binding]; other site 1032480002296 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1032480002297 catalytic loop [active] 1032480002298 iron binding site [ion binding]; other site 1032480002299 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1032480002300 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1032480002301 [2Fe-2S] cluster binding site [ion binding]; other site 1032480002302 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 1032480002303 putative alpha subunit interface [polypeptide binding]; other site 1032480002304 putative active site [active] 1032480002305 putative substrate binding site [chemical binding]; other site 1032480002306 Fe binding site [ion binding]; other site 1032480002307 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1032480002308 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1032480002309 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 1032480002310 Walker A/P-loop; other site 1032480002311 ATP binding site [chemical binding]; other site 1032480002312 Q-loop/lid; other site 1032480002313 ABC transporter signature motif; other site 1032480002314 Walker B; other site 1032480002315 D-loop; other site 1032480002316 H-loop/switch region; other site 1032480002317 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1032480002318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480002319 dimer interface [polypeptide binding]; other site 1032480002320 conserved gate region; other site 1032480002321 ABC-ATPase subunit interface; other site 1032480002322 NMT1-like family; Region: NMT1_2; cl15260 1032480002323 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1032480002324 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 1032480002325 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 1032480002326 NAD binding site [chemical binding]; other site 1032480002327 catalytic Zn binding site [ion binding]; other site 1032480002328 structural Zn binding site [ion binding]; other site 1032480002329 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480002330 DNA-binding site [nucleotide binding]; DNA binding site 1032480002331 benzoate transport; Region: 2A0115; TIGR00895 1032480002332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480002333 putative substrate translocation pore; other site 1032480002334 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1032480002335 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1032480002336 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480002337 DNA-binding site [nucleotide binding]; DNA binding site 1032480002338 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480002339 Helix-turn-helix domains; Region: HTH; cl00088 1032480002340 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1032480002341 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1032480002342 active site 1032480002343 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1032480002344 putative active site [active] 1032480002345 putative catalytic site [active] 1032480002346 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1032480002347 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1032480002348 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1032480002349 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1032480002350 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1032480002351 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1032480002352 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1032480002353 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1032480002354 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1032480002355 carboxyltransferase (CT) interaction site; other site 1032480002356 biotinylation site [posttranslational modification]; other site 1032480002357 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1032480002358 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1032480002359 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1032480002360 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1032480002361 putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK05641 1032480002362 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1032480002363 carboxyltransferase (CT) interaction site; other site 1032480002364 biotinylation site [posttranslational modification]; other site 1032480002365 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 1032480002366 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1032480002367 Domain of unknown function (DUF309); Region: DUF309; cl00667 1032480002368 Helix-turn-helix domains; Region: HTH; cl00088 1032480002369 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1032480002370 Cupin domain; Region: Cupin_2; cl09118 1032480002371 WYL domain; Region: WYL; cl14852 1032480002372 WYL domain; Region: WYL; cl14852 1032480002373 Helix-turn-helix domains; Region: HTH; cl00088 1032480002374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480002375 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1032480002376 putative substrate translocation pore; other site 1032480002377 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1032480002378 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480002379 Helix-turn-helix domains; Region: HTH; cl00088 1032480002380 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1032480002381 active site 1032480002382 metal binding site [ion binding]; metal-binding site 1032480002383 homotetramer interface [polypeptide binding]; other site 1032480002384 hypothetical protein; Provisional; Region: PRK06541 1032480002385 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1032480002386 inhibitor-cofactor binding pocket; inhibition site 1032480002387 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480002388 catalytic residue [active] 1032480002389 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 1032480002390 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1032480002391 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1032480002392 homodimer interface [polypeptide binding]; other site 1032480002393 active site 1032480002394 TDP-binding site; other site 1032480002395 acceptor substrate-binding pocket; other site 1032480002396 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1032480002397 catalytic core [active] 1032480002398 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1032480002399 active site 1032480002400 metal binding site [ion binding]; metal-binding site 1032480002401 NAD synthetase; Reviewed; Region: nadE; PRK02628 1032480002402 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1032480002403 multimer interface [polypeptide binding]; other site 1032480002404 active site 1032480002405 catalytic triad [active] 1032480002406 protein interface 1 [polypeptide binding]; other site 1032480002407 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1032480002408 homodimer interface [polypeptide binding]; other site 1032480002409 NAD binding pocket [chemical binding]; other site 1032480002410 ATP binding pocket [chemical binding]; other site 1032480002411 Mg binding site [ion binding]; other site 1032480002412 active-site loop [active] 1032480002413 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1032480002414 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480002415 NAD(P) binding site [chemical binding]; other site 1032480002416 active site 1032480002417 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1032480002418 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1032480002419 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1032480002420 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1032480002421 hypothetical protein; Provisional; Region: PRK07877 1032480002422 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1032480002423 Fic family protein [Function unknown]; Region: COG3177 1032480002424 Fic/DOC family; Region: Fic; cl00960 1032480002425 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1032480002426 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1032480002427 dimer interface [polypeptide binding]; other site 1032480002428 phosphorylation site [posttranslational modification] 1032480002429 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480002430 ATP binding site [chemical binding]; other site 1032480002431 Mg2+ binding site [ion binding]; other site 1032480002432 G-X-G motif; other site 1032480002433 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1032480002434 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480002435 active site 1032480002436 phosphorylation site [posttranslational modification] 1032480002437 intermolecular recognition site; other site 1032480002438 dimerization interface [polypeptide binding]; other site 1032480002439 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1032480002440 DNA binding site [nucleotide binding] 1032480002441 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1032480002442 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480002443 Walker A/P-loop; other site 1032480002444 ATP binding site [chemical binding]; other site 1032480002445 Q-loop/lid; other site 1032480002446 ABC transporter signature motif; other site 1032480002447 Walker B; other site 1032480002448 D-loop; other site 1032480002449 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1032480002450 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1032480002451 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1032480002452 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1032480002453 Protease prsW family; Region: PrsW-protease; cl15823 1032480002454 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 1032480002455 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 1032480002456 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1032480002457 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1032480002458 putative active site [active] 1032480002459 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1032480002460 active site 1032480002461 catalytic site [active] 1032480002462 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1032480002463 active site 1032480002464 catalytic site [active] 1032480002465 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1032480002466 FAD binding domain; Region: FAD_binding_4; pfam01565 1032480002467 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1032480002468 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1032480002469 AMP-binding enzyme; Region: AMP-binding; cl15778 1032480002470 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480002471 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1032480002472 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480002473 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480002474 homodimer interface [polypeptide binding]; other site 1032480002475 catalytic residue [active] 1032480002476 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 1032480002477 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1032480002478 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1032480002479 putative homodimer interface [polypeptide binding]; other site 1032480002480 KOW motif; Region: KOW; cl00354 1032480002481 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1032480002482 L7/L12 interface [polypeptide binding]; other site 1032480002483 23S rRNA interface [nucleotide binding]; other site 1032480002484 L25 interface [polypeptide binding]; other site 1032480002485 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1032480002486 mRNA/rRNA interface [nucleotide binding]; other site 1032480002487 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480002488 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480002489 NlpC/P60 family; Region: NLPC_P60; cl11438 1032480002490 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1032480002491 23S rRNA interface [nucleotide binding]; other site 1032480002492 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1032480002493 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1032480002494 core dimer interface [polypeptide binding]; other site 1032480002495 peripheral dimer interface [polypeptide binding]; other site 1032480002496 L10 interface [polypeptide binding]; other site 1032480002497 L11 interface [polypeptide binding]; other site 1032480002498 putative EF-Tu interaction site [polypeptide binding]; other site 1032480002499 putative EF-G interaction site [polypeptide binding]; other site 1032480002500 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1032480002501 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 1032480002502 Walker A/P-loop; other site 1032480002503 ATP binding site [chemical binding]; other site 1032480002504 Q-loop/lid; other site 1032480002505 ABC transporter signature motif; other site 1032480002506 Walker B; other site 1032480002507 D-loop; other site 1032480002508 H-loop/switch region; other site 1032480002509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1032480002510 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1032480002511 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480002512 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1032480002513 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480002514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480002515 active site 1032480002516 phosphorylation site [posttranslational modification] 1032480002517 intermolecular recognition site; other site 1032480002518 dimerization interface [polypeptide binding]; other site 1032480002519 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480002520 DNA binding residues [nucleotide binding] 1032480002521 dimerization interface [polypeptide binding]; other site 1032480002522 Histidine kinase; Region: HisKA_3; pfam07730 1032480002523 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480002524 ATP binding site [chemical binding]; other site 1032480002525 Mg2+ binding site [ion binding]; other site 1032480002526 G-X-G motif; other site 1032480002527 Domain of unknown function (DUF718); Region: DUF718; cl01281 1032480002528 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1032480002529 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 1032480002530 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1032480002531 RPB1 interaction site [polypeptide binding]; other site 1032480002532 RPB10 interaction site [polypeptide binding]; other site 1032480002533 RPB11 interaction site [polypeptide binding]; other site 1032480002534 RPB3 interaction site [polypeptide binding]; other site 1032480002535 RPB12 interaction site [polypeptide binding]; other site 1032480002536 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1032480002537 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1032480002538 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 1032480002539 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1032480002540 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1032480002541 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1032480002542 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1032480002543 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1032480002544 G-loop; other site 1032480002545 DNA binding site [nucleotide binding] 1032480002546 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1032480002547 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1032480002548 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1032480002549 TM-ABC transporter signature motif; other site 1032480002550 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1032480002551 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 1032480002552 Walker A/P-loop; other site 1032480002553 ATP binding site [chemical binding]; other site 1032480002554 Q-loop/lid; other site 1032480002555 ABC transporter signature motif; other site 1032480002556 Walker B; other site 1032480002557 D-loop; other site 1032480002558 H-loop/switch region; other site 1032480002559 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 1032480002560 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1032480002561 Helix-turn-helix domains; Region: HTH; cl00088 1032480002562 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1032480002563 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1032480002564 L-xylulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 1032480002565 putative N- and C-terminal domain interface [polypeptide binding]; other site 1032480002566 putative active site [active] 1032480002567 putative MgATP binding site [chemical binding]; other site 1032480002568 catalytic site [active] 1032480002569 metal binding site [ion binding]; metal-binding site 1032480002570 putative xylulose binding site [chemical binding]; other site 1032480002571 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480002572 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1032480002573 NAD(P) binding site [chemical binding]; other site 1032480002574 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 1032480002575 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1032480002576 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1032480002577 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1032480002578 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1032480002579 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1032480002580 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1032480002581 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1032480002582 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480002583 DNA-binding site [nucleotide binding]; DNA binding site 1032480002584 FCD domain; Region: FCD; cl11656 1032480002585 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480002586 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480002587 active site 1032480002588 catalytic tetrad [active] 1032480002589 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1032480002590 S17 interaction site [polypeptide binding]; other site 1032480002591 S8 interaction site; other site 1032480002592 16S rRNA interaction site [nucleotide binding]; other site 1032480002593 streptomycin interaction site [chemical binding]; other site 1032480002594 23S rRNA interaction site [nucleotide binding]; other site 1032480002595 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1032480002596 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 1032480002597 elongation factor G; Reviewed; Region: PRK00007 1032480002598 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1032480002599 G1 box; other site 1032480002600 putative GEF interaction site [polypeptide binding]; other site 1032480002601 GTP/Mg2+ binding site [chemical binding]; other site 1032480002602 Switch I region; other site 1032480002603 G2 box; other site 1032480002604 G3 box; other site 1032480002605 Switch II region; other site 1032480002606 G4 box; other site 1032480002607 G5 box; other site 1032480002608 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1032480002609 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1032480002610 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1032480002611 elongation factor Tu; Reviewed; Region: PRK00049 1032480002612 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1032480002613 G1 box; other site 1032480002614 GEF interaction site [polypeptide binding]; other site 1032480002615 GTP/Mg2+ binding site [chemical binding]; other site 1032480002616 Switch I region; other site 1032480002617 G2 box; other site 1032480002618 G3 box; other site 1032480002619 Switch II region; other site 1032480002620 G4 box; other site 1032480002621 G5 box; other site 1032480002622 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1032480002623 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1032480002624 Antibiotic Binding Site [chemical binding]; other site 1032480002625 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1032480002626 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1032480002627 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1032480002628 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1032480002629 Walker A/P-loop; other site 1032480002630 ATP binding site [chemical binding]; other site 1032480002631 Q-loop/lid; other site 1032480002632 ABC transporter signature motif; other site 1032480002633 Walker B; other site 1032480002634 D-loop; other site 1032480002635 H-loop/switch region; other site 1032480002636 Histidine kinase; Region: HisKA_3; pfam07730 1032480002637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480002638 ATP binding site [chemical binding]; other site 1032480002639 Mg2+ binding site [ion binding]; other site 1032480002640 G-X-G motif; other site 1032480002641 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480002642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480002643 active site 1032480002644 phosphorylation site [posttranslational modification] 1032480002645 intermolecular recognition site; other site 1032480002646 dimerization interface [polypeptide binding]; other site 1032480002647 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480002648 DNA binding residues [nucleotide binding] 1032480002649 dimerization interface [polypeptide binding]; other site 1032480002650 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1032480002651 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 1032480002652 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 1032480002653 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1032480002654 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 1032480002655 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1032480002656 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1032480002657 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1032480002658 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 1032480002659 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1032480002660 putative translocon binding site; other site 1032480002661 protein-rRNA interface [nucleotide binding]; other site 1032480002662 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 1032480002663 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1032480002664 G-X-X-G motif; other site 1032480002665 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1032480002666 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1032480002667 23S rRNA interface [nucleotide binding]; other site 1032480002668 5S rRNA interface [nucleotide binding]; other site 1032480002669 putative antibiotic binding site [chemical binding]; other site 1032480002670 L25 interface [polypeptide binding]; other site 1032480002671 L27 interface [polypeptide binding]; other site 1032480002672 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1032480002673 23S rRNA interface [nucleotide binding]; other site 1032480002674 putative translocon interaction site; other site 1032480002675 signal recognition particle (SRP54) interaction site; other site 1032480002676 L23 interface [polypeptide binding]; other site 1032480002677 trigger factor interaction site; other site 1032480002678 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 1032480002679 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 1032480002680 KOW motif; Region: KOW; cl00354 1032480002681 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1032480002682 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1032480002683 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1032480002684 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1032480002685 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 1032480002686 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 1032480002687 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1032480002688 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1032480002689 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1032480002690 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1032480002691 5S rRNA interface [nucleotide binding]; other site 1032480002692 L27 interface [polypeptide binding]; other site 1032480002693 23S rRNA interface [nucleotide binding]; other site 1032480002694 L5 interface [polypeptide binding]; other site 1032480002695 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1032480002696 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1032480002697 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1032480002698 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1032480002699 23S rRNA binding site [nucleotide binding]; other site 1032480002700 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 1032480002701 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1032480002702 SecY translocase; Region: SecY; pfam00344 1032480002703 adenylate kinase; Reviewed; Region: adk; PRK00279 1032480002704 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1032480002705 AMP-binding site [chemical binding]; other site 1032480002706 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1032480002707 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1032480002708 active site 1032480002709 TIGR03086 family protein; Region: TIGR03086 1032480002710 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1032480002711 hydrophobic ligand binding site; other site 1032480002712 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480002713 dimerization interface [polypeptide binding]; other site 1032480002714 putative DNA binding site [nucleotide binding]; other site 1032480002715 putative Zn2+ binding site [ion binding]; other site 1032480002716 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1032480002717 dimerization interface [polypeptide binding]; other site 1032480002718 substrate binding pocket [chemical binding]; other site 1032480002719 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480002720 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1032480002721 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1032480002722 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1032480002723 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480002724 Helix-turn-helix domains; Region: HTH; cl00088 1032480002725 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1032480002726 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1032480002727 active site 1032480002728 ATP binding site [chemical binding]; other site 1032480002729 substrate binding site [chemical binding]; other site 1032480002730 activation loop (A-loop); other site 1032480002731 CRISPR-associated protein; Region: TIGR03986 1032480002732 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 1032480002733 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 1032480002734 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 1032480002735 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 1032480002736 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 1032480002737 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 1032480002738 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1032480002739 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 1032480002740 NTP binding site [chemical binding]; other site 1032480002741 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 1032480002742 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 1032480002743 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1032480002744 CRISPR-associated protein; Region: TIGR03986 1032480002745 CRISPR-associated protein; Region: TIGR03986 1032480002746 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 1032480002747 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 1032480002748 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 1032480002749 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 1032480002750 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 1032480002751 Raffinose synthase or seed inhibition protein Sip1; Region: Raffinose_syn; cl14104 1032480002752 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 1032480002753 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 1032480002754 cofactor binding site; other site 1032480002755 DNA binding site [nucleotide binding] 1032480002756 substrate interaction site [chemical binding]; other site 1032480002757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 1032480002758 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1032480002759 additional DNA contacts [nucleotide binding]; other site 1032480002760 mismatch recognition site; other site 1032480002761 active site 1032480002762 zinc binding site [ion binding]; other site 1032480002763 DNA intercalation site [nucleotide binding]; other site 1032480002764 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 1032480002765 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1032480002766 Predicted transcriptional regulator [Transcription]; Region: COG2345 1032480002767 Helix-turn-helix domains; Region: HTH; cl00088 1032480002768 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 1032480002769 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1032480002770 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 1032480002771 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1032480002772 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 1032480002773 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 1032480002774 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1032480002775 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 1032480002776 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1032480002777 Divergent AAA domain; Region: AAA_4; pfam04326 1032480002778 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1032480002779 rRNA binding site [nucleotide binding]; other site 1032480002780 predicted 30S ribosome binding site; other site 1032480002781 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 1032480002782 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 1032480002783 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1032480002784 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 1032480002785 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1032480002786 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1032480002787 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1032480002788 RNA binding surface [nucleotide binding]; other site 1032480002789 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1032480002790 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1032480002791 alphaNTD - beta interaction site [polypeptide binding]; other site 1032480002792 alphaNTD homodimer interface [polypeptide binding]; other site 1032480002793 alphaNTD - beta' interaction site [polypeptide binding]; other site 1032480002794 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 1032480002795 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 1032480002796 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480002797 motif II; other site 1032480002798 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1032480002799 putative hydrophobic ligand binding site [chemical binding]; other site 1032480002800 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1032480002801 hydrophobic ligand binding site; other site 1032480002802 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480002803 dimerization interface [polypeptide binding]; other site 1032480002804 putative DNA binding site [nucleotide binding]; other site 1032480002805 putative Zn2+ binding site [ion binding]; other site 1032480002806 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1032480002807 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1032480002808 Walker A/P-loop; other site 1032480002809 ATP binding site [chemical binding]; other site 1032480002810 Q-loop/lid; other site 1032480002811 ABC transporter signature motif; other site 1032480002812 Walker B; other site 1032480002813 D-loop; other site 1032480002814 H-loop/switch region; other site 1032480002815 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1032480002816 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1032480002817 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1032480002818 Walker A/P-loop; other site 1032480002819 ATP binding site [chemical binding]; other site 1032480002820 Q-loop/lid; other site 1032480002821 ABC transporter signature motif; other site 1032480002822 Walker B; other site 1032480002823 D-loop; other site 1032480002824 H-loop/switch region; other site 1032480002825 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1032480002826 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1032480002827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480002828 putative PBP binding loops; other site 1032480002829 ABC-ATPase subunit interface; other site 1032480002830 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1032480002831 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480002832 dimer interface [polypeptide binding]; other site 1032480002833 conserved gate region; other site 1032480002834 putative PBP binding loops; other site 1032480002835 ABC-ATPase subunit interface; other site 1032480002836 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 1032480002837 substrate binding site [chemical binding]; other site 1032480002838 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1032480002839 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 1032480002840 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 1032480002841 active site 1032480002842 DNA binding site [nucleotide binding] 1032480002843 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1032480002844 DNA binding site [nucleotide binding] 1032480002845 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1032480002846 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1032480002847 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1032480002848 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1032480002849 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1032480002850 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1032480002851 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1032480002852 Walker A/P-loop; other site 1032480002853 ATP binding site [chemical binding]; other site 1032480002854 Q-loop/lid; other site 1032480002855 ABC transporter signature motif; other site 1032480002856 Walker B; other site 1032480002857 D-loop; other site 1032480002858 H-loop/switch region; other site 1032480002859 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 1032480002860 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480002861 S-adenosylmethionine binding site [chemical binding]; other site 1032480002862 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1032480002863 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 1032480002864 dimerization interface 3.5A [polypeptide binding]; other site 1032480002865 active site 1032480002866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 1032480002867 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1032480002868 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 1032480002869 Walker A/P-loop; other site 1032480002870 ATP binding site [chemical binding]; other site 1032480002871 Q-loop/lid; other site 1032480002872 ABC transporter signature motif; other site 1032480002873 Walker B; other site 1032480002874 D-loop; other site 1032480002875 H-loop/switch region; other site 1032480002876 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 1032480002877 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 1032480002878 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1032480002879 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480002880 Walker A/P-loop; other site 1032480002881 ATP binding site [chemical binding]; other site 1032480002882 Q-loop/lid; other site 1032480002883 ABC transporter signature motif; other site 1032480002884 Walker B; other site 1032480002885 D-loop; other site 1032480002886 H-loop/switch region; other site 1032480002887 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1032480002888 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1032480002889 Citrate synthase; Region: Citrate_synt; pfam00285 1032480002890 oxalacetate binding site [chemical binding]; other site 1032480002891 citrylCoA binding site [chemical binding]; other site 1032480002892 coenzyme A binding site [chemical binding]; other site 1032480002893 catalytic triad [active] 1032480002894 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1032480002895 23S rRNA interface [nucleotide binding]; other site 1032480002896 L3 interface [polypeptide binding]; other site 1032480002897 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 1032480002898 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1032480002899 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1032480002900 active site 1032480002901 substrate binding site [chemical binding]; other site 1032480002902 metal binding site [ion binding]; metal-binding site 1032480002903 pantothenate kinase; Provisional; Region: PRK05439 1032480002904 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 1032480002905 ATP-binding site [chemical binding]; other site 1032480002906 CoA-binding site [chemical binding]; other site 1032480002907 Mg2+-binding site [ion binding]; other site 1032480002908 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1032480002909 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1032480002910 glutaminase active site [active] 1032480002911 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1032480002912 dimer interface [polypeptide binding]; other site 1032480002913 active site 1032480002914 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1032480002915 dimer interface [polypeptide binding]; other site 1032480002916 active site 1032480002917 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1032480002918 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 1032480002919 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1032480002920 alanine racemase; Reviewed; Region: alr; PRK00053 1032480002921 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1032480002922 active site 1032480002923 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1032480002924 dimer interface [polypeptide binding]; other site 1032480002925 substrate binding site [chemical binding]; other site 1032480002926 catalytic residues [active] 1032480002927 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480002928 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480002929 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1032480002930 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480002931 motif II; other site 1032480002932 transcription termination factor Rho; Provisional; Region: PRK12678 1032480002933 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1032480002934 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1032480002935 ATP binding site [chemical binding]; other site 1032480002936 Mg++ binding site [ion binding]; other site 1032480002937 motif III; other site 1032480002938 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480002939 nucleotide binding region [chemical binding]; other site 1032480002940 ATP-binding site [chemical binding]; other site 1032480002941 putative acetyltransferase; Provisional; Region: PRK03624 1032480002942 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480002943 Coenzyme A binding pocket [chemical binding]; other site 1032480002944 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 1032480002945 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1032480002946 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480002947 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480002948 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1032480002949 CoenzymeA binding site [chemical binding]; other site 1032480002950 subunit interaction site [polypeptide binding]; other site 1032480002951 PHB binding site; other site 1032480002952 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1032480002953 oligomerisation interface [polypeptide binding]; other site 1032480002954 mobile loop; other site 1032480002955 roof hairpin; other site 1032480002956 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1032480002957 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1032480002958 ring oligomerisation interface [polypeptide binding]; other site 1032480002959 ATP/Mg binding site [chemical binding]; other site 1032480002960 stacking interactions; other site 1032480002961 hinge regions; other site 1032480002962 Winged helix-turn helix; Region: HTH_29; pfam13551 1032480002963 Integrase core domain; Region: rve; cl01316 1032480002964 Integrase core domain; Region: rve_3; cl15866 1032480002965 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1032480002966 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1032480002967 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1032480002968 active site 1032480002969 Zn binding site [ion binding]; other site 1032480002970 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1032480002971 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1032480002972 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1032480002973 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 1032480002974 active site 1032480002975 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1032480002976 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1032480002977 phosphate binding site [ion binding]; other site 1032480002978 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1032480002979 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1032480002980 Subtilisin inhibitor-like; Region: SSI; cl11594 1032480002981 Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852 1032480002982 active site 1032480002983 catalytic triad [active] 1032480002984 PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from...; Region: PA_subtilisin_like; cd02120 1032480002985 PA/protease or protease-like domain interface [polypeptide binding]; other site 1032480002986 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1032480002987 Chorismate mutase type II; Region: CM_2; cl00693 1032480002988 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1032480002989 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1032480002990 NAD(P) binding site [chemical binding]; other site 1032480002991 catalytic residues [active] 1032480002992 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1032480002993 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480002994 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480002995 Coenzyme A binding pocket [chemical binding]; other site 1032480002996 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480002997 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480002998 Dehydratase family; Region: ILVD_EDD; cl00340 1032480002999 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 1032480003000 GMP synthase; Reviewed; Region: guaA; PRK00074 1032480003001 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1032480003002 AMP/PPi binding site [chemical binding]; other site 1032480003003 candidate oxyanion hole; other site 1032480003004 catalytic triad [active] 1032480003005 potential glutamine specificity residues [chemical binding]; other site 1032480003006 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1032480003007 ATP Binding subdomain [chemical binding]; other site 1032480003008 Ligand Binding sites [chemical binding]; other site 1032480003009 Dimerization subdomain; other site 1032480003010 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1032480003011 PspC domain; Region: PspC; cl00864 1032480003012 PspC domain; Region: PspC; cl00864 1032480003013 PspC domain; Region: PspC; cl00864 1032480003014 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1032480003015 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480003016 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480003017 active site 1032480003018 phosphorylation site [posttranslational modification] 1032480003019 intermolecular recognition site; other site 1032480003020 dimerization interface [polypeptide binding]; other site 1032480003021 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480003022 DNA binding residues [nucleotide binding] 1032480003023 dimerization interface [polypeptide binding]; other site 1032480003024 Predicted transcriptional regulator [Transcription]; Region: COG1959 1032480003025 Helix-turn-helix domains; Region: HTH; cl00088 1032480003026 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480003027 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 1032480003028 dimer interface [polypeptide binding]; other site 1032480003029 putative metal binding site [ion binding]; other site 1032480003030 PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and...; Region: PLAT; cl00011 1032480003031 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1032480003032 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1032480003033 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1032480003034 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1032480003035 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1032480003036 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1032480003037 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1032480003038 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1032480003039 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 1032480003040 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1032480003041 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1032480003042 phosphate binding site [ion binding]; other site 1032480003043 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1032480003044 putative active site [active] 1032480003045 catalytic site [active] 1032480003046 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1032480003047 PLD-like domain; Region: PLDc_2; pfam13091 1032480003048 putative active site [active] 1032480003049 catalytic site [active] 1032480003050 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1032480003051 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480003052 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1032480003053 Peptidase family M23; Region: Peptidase_M23; pfam01551 1032480003054 Peptidase family M23; Region: Peptidase_M23; pfam01551 1032480003055 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1032480003056 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 1032480003057 nucleophilic elbow; other site 1032480003058 catalytic triad; other site 1032480003059 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1032480003060 B12 binding site [chemical binding]; other site 1032480003061 cobalt ligand [ion binding]; other site 1032480003062 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1032480003063 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1032480003064 CoA-ligase; Region: Ligase_CoA; cl02894 1032480003065 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1032480003066 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480003067 CoA-ligase; Region: Ligase_CoA; cl02894 1032480003068 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1032480003069 dimer interface [polypeptide binding]; other site 1032480003070 ADP-ribose binding site [chemical binding]; other site 1032480003071 active site 1032480003072 nudix motif; other site 1032480003073 metal binding site [ion binding]; metal-binding site 1032480003074 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1032480003075 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480003076 G1 box; other site 1032480003077 GTP/Mg2+ binding site [chemical binding]; other site 1032480003078 G2 box; other site 1032480003079 Switch I region; other site 1032480003080 G3 box; other site 1032480003081 Switch II region; other site 1032480003082 G4 box; other site 1032480003083 G5 box; other site 1032480003084 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 1032480003085 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 1032480003086 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 1032480003087 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1032480003088 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1032480003089 active site 1032480003090 substrate binding site [chemical binding]; other site 1032480003091 cosubstrate binding site; other site 1032480003092 catalytic site [active] 1032480003093 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1032480003094 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1032480003095 purine monophosphate binding site [chemical binding]; other site 1032480003096 dimer interface [polypeptide binding]; other site 1032480003097 putative catalytic residues [active] 1032480003098 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1032480003099 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1032480003100 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1032480003101 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1032480003102 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1032480003103 homodimer interface [polypeptide binding]; other site 1032480003104 NADP binding site [chemical binding]; other site 1032480003105 substrate binding site [chemical binding]; other site 1032480003106 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480003107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480003108 active site 1032480003109 phosphorylation site [posttranslational modification] 1032480003110 intermolecular recognition site; other site 1032480003111 dimerization interface [polypeptide binding]; other site 1032480003112 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480003113 DNA binding residues [nucleotide binding] 1032480003114 dimerization interface [polypeptide binding]; other site 1032480003115 Histidine kinase; Region: HisKA_3; pfam07730 1032480003116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1032480003117 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1032480003118 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480003119 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1032480003120 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1032480003121 metal binding site [ion binding]; metal-binding site 1032480003122 dimer interface [polypeptide binding]; other site 1032480003123 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1032480003124 malate dehydrogenase; Provisional; Region: PRK05442 1032480003125 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1032480003126 NAD(P) binding site [chemical binding]; other site 1032480003127 dimer interface [polypeptide binding]; other site 1032480003128 malate binding site [chemical binding]; other site 1032480003129 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480003130 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1032480003131 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1032480003132 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 1032480003133 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1032480003134 Helix-turn-helix domains; Region: HTH; cl00088 1032480003135 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 1032480003136 substrate binding pocket [chemical binding]; other site 1032480003137 dimerization interface [polypeptide binding]; other site 1032480003138 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1032480003139 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480003140 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1032480003141 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1032480003142 active site 1032480003143 catalytic site [active] 1032480003144 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1032480003145 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1032480003146 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1032480003147 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1032480003148 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1032480003149 NAD(P) binding site [chemical binding]; other site 1032480003150 shikimate binding site; other site 1032480003151 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1032480003152 trimer interface [polypeptide binding]; other site 1032480003153 active site 1032480003154 dimer interface [polypeptide binding]; other site 1032480003155 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1032480003156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480003157 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1032480003158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480003159 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1032480003160 active site 1032480003161 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1032480003162 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480003163 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1032480003164 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480003165 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1032480003166 Domain of unknown function DUF21; Region: DUF21; pfam01595 1032480003167 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1032480003168 Transporter associated domain; Region: CorC_HlyC; cl08393 1032480003169 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1032480003170 active site 1032480003171 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1032480003172 HIGH motif; other site 1032480003173 dimer interface [polypeptide binding]; other site 1032480003174 KMSKS motif; other site 1032480003175 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1032480003176 catalytic triad [active] 1032480003177 conserved cis-peptide bond; other site 1032480003178 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1032480003179 active site 1032480003180 metal binding site [ion binding]; metal-binding site 1032480003181 Uncharacterized conserved protein [Function unknown]; Region: COG4715 1032480003182 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1032480003183 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480003184 ATP binding site [chemical binding]; other site 1032480003185 putative Mg++ binding site [ion binding]; other site 1032480003186 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480003187 nucleotide binding region [chemical binding]; other site 1032480003188 ATP-binding site [chemical binding]; other site 1032480003189 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1032480003190 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480003191 active site 1032480003192 ATP binding site [chemical binding]; other site 1032480003193 substrate binding site [chemical binding]; other site 1032480003194 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1032480003195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480003196 active site 1032480003197 phosphorylation site [posttranslational modification] 1032480003198 intermolecular recognition site; other site 1032480003199 dimerization interface [polypeptide binding]; other site 1032480003200 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1032480003201 DNA binding site [nucleotide binding] 1032480003202 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 1032480003203 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1032480003204 dimerization interface [polypeptide binding]; other site 1032480003205 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1032480003206 dimer interface [polypeptide binding]; other site 1032480003207 phosphorylation site [posttranslational modification] 1032480003208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480003209 ATP binding site [chemical binding]; other site 1032480003210 Mg2+ binding site [ion binding]; other site 1032480003211 G-X-G motif; other site 1032480003212 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1032480003213 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480003214 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1032480003215 active site 1032480003216 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 1032480003217 classical (c) SDRs; Region: SDR_c; cd05233 1032480003218 NAD(P) binding site [chemical binding]; other site 1032480003219 active site 1032480003220 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1032480003221 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1032480003222 Walker A/P-loop; other site 1032480003223 ATP binding site [chemical binding]; other site 1032480003224 Q-loop/lid; other site 1032480003225 ABC transporter signature motif; other site 1032480003226 Walker B; other site 1032480003227 D-loop; other site 1032480003228 H-loop/switch region; other site 1032480003229 Helix-turn-helix domains; Region: HTH; cl00088 1032480003230 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1032480003231 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1032480003232 FAD binding pocket [chemical binding]; other site 1032480003233 FAD binding motif [chemical binding]; other site 1032480003234 phosphate binding motif [ion binding]; other site 1032480003235 NAD binding pocket [chemical binding]; other site 1032480003236 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1032480003237 amidohydrolase; Region: amidohydrolases; TIGR01891 1032480003238 metal binding site [ion binding]; metal-binding site 1032480003239 putative dimer interface [polypeptide binding]; other site 1032480003240 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1032480003241 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1032480003242 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1032480003243 putative active site [active] 1032480003244 catalytic site [active] 1032480003245 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1032480003246 putative active site [active] 1032480003247 catalytic site [active] 1032480003248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480003249 S-adenosylmethionine binding site [chemical binding]; other site 1032480003250 Peptidase family M23; Region: Peptidase_M23; pfam01551 1032480003251 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1032480003252 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1032480003253 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1032480003254 active site 1032480003255 HIGH motif; other site 1032480003256 KMSKS motif; other site 1032480003257 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1032480003258 tRNA binding surface [nucleotide binding]; other site 1032480003259 anticodon binding site; other site 1032480003260 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 1032480003261 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1032480003262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480003263 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1032480003264 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1032480003265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480003266 S-adenosylmethionine binding site [chemical binding]; other site 1032480003267 prephenate dehydratase; Provisional; Region: PRK11899 1032480003268 Prephenate dehydratase; Region: PDT; pfam00800 1032480003269 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1032480003270 putative L-Phe binding site [chemical binding]; other site 1032480003271 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 1032480003272 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1032480003273 homodimer interface [polypeptide binding]; other site 1032480003274 substrate-cofactor binding pocket; other site 1032480003275 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480003276 catalytic residue [active] 1032480003277 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1032480003278 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480003279 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1032480003280 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1032480003281 active site 1032480003282 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1032480003283 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1032480003284 active site 1032480003285 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1032480003286 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1032480003287 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480003288 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1032480003289 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1032480003290 active site 1032480003291 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1032480003292 tetramer interface [polypeptide binding]; other site 1032480003293 TPP-binding site [chemical binding]; other site 1032480003294 heterodimer interface [polypeptide binding]; other site 1032480003295 phosphorylation loop region [posttranslational modification] 1032480003296 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1032480003297 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1032480003298 PYR/PP interface [polypeptide binding]; other site 1032480003299 dimer interface [polypeptide binding]; other site 1032480003300 TPP binding site [chemical binding]; other site 1032480003301 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1032480003302 L-lysine aminotransferase; Provisional; Region: PRK08297 1032480003303 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1032480003304 inhibitor-cofactor binding pocket; inhibition site 1032480003305 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480003306 catalytic residue [active] 1032480003307 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1032480003308 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1032480003309 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1032480003310 putative active site pocket [active] 1032480003311 dimerization interface [polypeptide binding]; other site 1032480003312 putative catalytic residue [active] 1032480003313 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1032480003314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480003315 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1032480003316 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1032480003317 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480003318 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480003319 NAD-dependent deacetylase; Provisional; Region: PRK00481 1032480003320 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1032480003321 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480003322 DNA-binding site [nucleotide binding]; DNA binding site 1032480003323 FCD domain; Region: FCD; cl11656 1032480003324 GntP family permease; Region: GntP_permease; pfam02447 1032480003325 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 1032480003326 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1032480003327 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 1032480003328 ATP-binding site [chemical binding]; other site 1032480003329 Gluconate-6-phosphate binding site [chemical binding]; other site 1032480003330 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1032480003331 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1032480003332 classical (c) SDRs; Region: SDR_c; cd05233 1032480003333 NAD(P) binding site [chemical binding]; other site 1032480003334 active site 1032480003335 FAD binding domain; Region: FAD_binding_4; pfam01565 1032480003336 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1032480003337 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 1032480003338 UbiA prenyltransferase family; Region: UbiA; cl00337 1032480003339 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1032480003340 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 1032480003341 Protein of unknown function (DUF993); Region: DUF993; pfam06187 1032480003342 potential frameshift: common BLAST hit: gi|134101169|ref|YP_001106830.1| oxidoreductase 1032480003343 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480003344 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480003345 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480003346 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480003347 DNA binding site [nucleotide binding] 1032480003348 domain linker motif; other site 1032480003349 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480003350 ligand binding site [chemical binding]; other site 1032480003351 dimerization interface [polypeptide binding]; other site 1032480003352 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1032480003353 Helix-turn-helix domains; Region: HTH; cl00088 1032480003354 Bacterial transcriptional regulator; Region: IclR; pfam01614 1032480003355 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1032480003356 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480003357 Maf-like protein; Region: Maf; pfam02545 1032480003358 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1032480003359 active site 1032480003360 dimer interface [polypeptide binding]; other site 1032480003361 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1032480003362 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1032480003363 active site 1032480003364 catalytic site [active] 1032480003365 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1032480003366 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1032480003367 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1032480003368 active site 1032480003369 catalytic site [active] 1032480003370 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1032480003371 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1032480003372 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1032480003373 Bacterial PH domain; Region: DUF304; cl01348 1032480003374 GtrA-like protein; Region: GtrA; cl00971 1032480003375 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1032480003376 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1032480003377 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1032480003378 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1032480003379 AIR carboxylase; Region: AIRC; cl00310 1032480003380 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 1032480003381 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 1032480003382 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480003383 active site 1032480003384 substrate binding site [chemical binding]; other site 1032480003385 ATP binding site [chemical binding]; other site 1032480003386 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 1032480003387 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1032480003388 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 1032480003389 potential frameshift: common BLAST hit: gi|162456351|ref|YP_001618718.1| transposase 1032480003390 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1032480003391 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1032480003392 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1032480003393 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 1032480003394 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 1032480003395 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 1032480003396 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1032480003397 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1032480003398 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1032480003399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480003400 dimer interface [polypeptide binding]; other site 1032480003401 conserved gate region; other site 1032480003402 putative PBP binding loops; other site 1032480003403 ABC-ATPase subunit interface; other site 1032480003404 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1032480003405 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1032480003406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480003407 dimer interface [polypeptide binding]; other site 1032480003408 conserved gate region; other site 1032480003409 putative PBP binding loops; other site 1032480003410 ABC-ATPase subunit interface; other site 1032480003411 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1032480003412 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1032480003413 Walker A/P-loop; other site 1032480003414 ATP binding site [chemical binding]; other site 1032480003415 Q-loop/lid; other site 1032480003416 ABC transporter signature motif; other site 1032480003417 Walker B; other site 1032480003418 D-loop; other site 1032480003419 H-loop/switch region; other site 1032480003420 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1032480003421 Walker A/P-loop; other site 1032480003422 ATP binding site [chemical binding]; other site 1032480003423 Q-loop/lid; other site 1032480003424 ABC transporter signature motif; other site 1032480003425 Walker B; other site 1032480003426 D-loop; other site 1032480003427 H-loop/switch region; other site 1032480003428 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1032480003429 active site 1032480003430 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1032480003431 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480003432 DNA-binding site [nucleotide binding]; DNA binding site 1032480003433 FCD domain; Region: FCD; cl11656 1032480003434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480003435 metabolite-proton symporter; Region: 2A0106; TIGR00883 1032480003436 putative substrate translocation pore; other site 1032480003437 LamB/YcsF family; Region: LamB_YcsF; cl00664 1032480003438 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1032480003439 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1032480003440 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 1032480003441 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1032480003442 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1032480003443 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1032480003444 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1032480003445 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1032480003446 carboxyltransferase (CT) interaction site; other site 1032480003447 biotinylation site [posttranslational modification]; other site 1032480003448 glyoxylate reductase; Reviewed; Region: PRK13243 1032480003449 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480003450 aspartate aminotransferase; Provisional; Region: PRK05764 1032480003451 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480003452 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480003453 homodimer interface [polypeptide binding]; other site 1032480003454 catalytic residue [active] 1032480003455 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1032480003456 ligand binding site [chemical binding]; other site 1032480003457 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1032480003458 phosphopeptide binding site; other site 1032480003459 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1032480003460 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480003461 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480003462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480003463 hypothetical protein; Provisional; Region: PRK07588 1032480003464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480003465 putative substrate translocation pore; other site 1032480003466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480003467 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1032480003468 Helix-turn-helix domains; Region: HTH; cl00088 1032480003469 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 1032480003470 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 1032480003471 Helix-turn-helix domains; Region: HTH; cl00088 1032480003472 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1032480003473 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1032480003474 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480003475 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1032480003476 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1032480003477 RHS Repeat; Region: RHS_repeat; cl11982 1032480003478 RHS Repeat; Region: RHS_repeat; cl11982 1032480003479 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1032480003480 RHS Repeat; Region: RHS_repeat; cl11982 1032480003481 RHS Repeat; Region: RHS_repeat; cl11982 1032480003482 RHS Repeat; Region: RHS_repeat; cl11982 1032480003483 RHS Repeat; Region: RHS_repeat; cl11982 1032480003484 RHS Repeat; Region: RHS_repeat; cl11982 1032480003485 RHS Repeat; Region: RHS_repeat; cl11982 1032480003486 RHS Repeat; Region: RHS_repeat; cl11982 1032480003487 RHS Repeat; Region: RHS_repeat; cl11982 1032480003488 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1032480003489 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1032480003490 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1032480003491 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1032480003492 active site 1032480003493 ATP binding site [chemical binding]; other site 1032480003494 substrate binding site [chemical binding]; other site 1032480003495 activation loop (A-loop); other site 1032480003496 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1032480003497 iron-sulfur cluster [ion binding]; other site 1032480003498 [2Fe-2S] cluster binding site [ion binding]; other site 1032480003499 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1032480003500 putative active site [active] 1032480003501 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1032480003502 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1032480003503 GIY-YIG motif/motif A; other site 1032480003504 active site 1032480003505 catalytic site [active] 1032480003506 putative DNA binding site [nucleotide binding]; other site 1032480003507 metal binding site [ion binding]; metal-binding site 1032480003508 UvrB/uvrC motif; Region: UVR; pfam02151 1032480003509 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1032480003510 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1032480003511 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 1032480003512 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 1032480003513 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1032480003514 putative substrate binding pocket [chemical binding]; other site 1032480003515 dimer interface [polypeptide binding]; other site 1032480003516 phosphate binding site [ion binding]; other site 1032480003517 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1032480003518 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1032480003519 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480003520 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1032480003521 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1032480003522 Phosphoglycerate kinase; Region: PGK; pfam00162 1032480003523 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1032480003524 substrate binding site [chemical binding]; other site 1032480003525 hinge regions; other site 1032480003526 ADP binding site [chemical binding]; other site 1032480003527 catalytic site [active] 1032480003528 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1032480003529 substrate binding site [chemical binding]; other site 1032480003530 dimer interface [polypeptide binding]; other site 1032480003531 catalytic triad [active] 1032480003532 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1032480003533 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1032480003534 putative active site [active] 1032480003535 opcA protein; Region: OpcA; TIGR00534 1032480003536 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 1032480003537 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1032480003538 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1032480003539 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1032480003540 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1032480003541 putative active site [active] 1032480003542 transaldolase; Provisional; Region: PRK03903 1032480003543 catalytic residue [active] 1032480003544 transketolase; Reviewed; Region: PRK05899 1032480003545 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1032480003546 TPP-binding site [chemical binding]; other site 1032480003547 dimer interface [polypeptide binding]; other site 1032480003548 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1032480003549 PYR/PP interface [polypeptide binding]; other site 1032480003550 dimer interface [polypeptide binding]; other site 1032480003551 TPP binding site [chemical binding]; other site 1032480003552 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1032480003553 UbiA prenyltransferase family; Region: UbiA; cl00337 1032480003554 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1032480003555 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480003556 Coenzyme A binding pocket [chemical binding]; other site 1032480003557 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480003558 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480003559 active site 1032480003560 substrate binding site [chemical binding]; other site 1032480003561 ATP binding site [chemical binding]; other site 1032480003562 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1032480003563 Transmembrane secretion effector; Region: MFS_3; pfam05977 1032480003564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 1032480003565 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1032480003566 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480003567 active site 1032480003568 motif I; other site 1032480003569 motif II; other site 1032480003570 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1032480003571 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1032480003572 RHS Repeat; Region: RHS_repeat; cl11982 1032480003573 RHS Repeat; Region: RHS_repeat; cl11982 1032480003574 RHS Repeat; Region: RHS_repeat; cl11982 1032480003575 RHS Repeat; Region: RHS_repeat; cl11982 1032480003576 RHS Repeat; Region: RHS_repeat; cl11982 1032480003577 RHS Repeat; Region: RHS_repeat; cl11982 1032480003578 RHS Repeat; Region: RHS_repeat; cl11982 1032480003579 RHS Repeat; Region: RHS_repeat; cl11982 1032480003580 RHS Repeat; Region: RHS_repeat; cl11982 1032480003581 RHS Repeat; Region: RHS_repeat; cl11982 1032480003582 RHS Repeat; Region: RHS_repeat; cl11982 1032480003583 RHS Repeat; Region: RHS_repeat; cl11982 1032480003584 RHS Repeat; Region: RHS_repeat; cl11982 1032480003585 RHS Repeat; Region: RHS_repeat; cl11982 1032480003586 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1032480003587 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1032480003588 protein-splicing catalytic site; other site 1032480003589 thioester formation/cholesterol transfer; other site 1032480003590 Pretoxin HINT domain; Region: PT-HINT; pfam07591 1032480003591 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480003592 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480003593 active site 1032480003594 ATP binding site [chemical binding]; other site 1032480003595 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480003596 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480003597 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480003598 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 1032480003599 NAD(P) binding site [chemical binding]; other site 1032480003600 active site 1032480003601 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480003602 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480003603 serine racemase; Region: PLN02970 1032480003604 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1032480003605 tetramer interface [polypeptide binding]; other site 1032480003606 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480003607 catalytic residue [active] 1032480003608 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 1032480003609 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1032480003610 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1032480003611 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1032480003612 Walker A/P-loop; other site 1032480003613 ATP binding site [chemical binding]; other site 1032480003614 Q-loop/lid; other site 1032480003615 ABC transporter signature motif; other site 1032480003616 Walker B; other site 1032480003617 D-loop; other site 1032480003618 H-loop/switch region; other site 1032480003619 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1032480003620 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1032480003621 active site 1032480003622 DNA binding site [nucleotide binding] 1032480003623 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1032480003624 DNA binding site [nucleotide binding] 1032480003625 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1032480003626 Helix-turn-helix domains; Region: HTH; cl00088 1032480003627 Predicted transcriptional regulator [Transcription]; Region: COG2345 1032480003628 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 1032480003629 FeS assembly protein SufB; Region: sufB; TIGR01980 1032480003630 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 1032480003631 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1032480003632 [2Fe-2S] cluster binding site [ion binding]; other site 1032480003633 FeS assembly ATPase SufC; Region: sufC; TIGR01978 1032480003634 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 1032480003635 Walker A/P-loop; other site 1032480003636 ATP binding site [chemical binding]; other site 1032480003637 Q-loop/lid; other site 1032480003638 ABC transporter signature motif; other site 1032480003639 Walker B; other site 1032480003640 D-loop; other site 1032480003641 H-loop/switch region; other site 1032480003642 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1032480003643 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1032480003644 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480003645 catalytic residue [active] 1032480003646 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1032480003647 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1032480003648 trimerization site [polypeptide binding]; other site 1032480003649 active site 1032480003650 Domain of unknown function DUF59; Region: DUF59; cl00941 1032480003651 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 1032480003652 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1032480003653 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480003654 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1032480003655 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480003656 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1032480003657 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1032480003658 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1032480003659 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1032480003660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480003661 S-adenosylmethionine binding site [chemical binding]; other site 1032480003662 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1032480003663 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480003664 NAD(P) binding site [chemical binding]; other site 1032480003665 active site 1032480003666 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1032480003667 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 1032480003668 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1032480003669 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1032480003670 FeS/SAM binding site; other site 1032480003671 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1032480003672 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1032480003673 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1032480003674 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1032480003675 NAD(P) binding site [chemical binding]; other site 1032480003676 homotetramer interface [polypeptide binding]; other site 1032480003677 homodimer interface [polypeptide binding]; other site 1032480003678 active site 1032480003679 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1032480003680 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480003681 NAD(P) binding site [chemical binding]; other site 1032480003682 active site 1032480003683 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1032480003684 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1032480003685 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 1032480003686 cyanophycin synthetase; Provisional; Region: PRK14016 1032480003687 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1032480003688 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1032480003689 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1032480003690 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1032480003691 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 1032480003692 proposed catalytic triad [active] 1032480003693 active site nucleophile [active] 1032480003694 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1032480003695 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480003696 Walker A/P-loop; other site 1032480003697 ATP binding site [chemical binding]; other site 1032480003698 ABC transporter signature motif; other site 1032480003699 Walker B; other site 1032480003700 D-loop; other site 1032480003701 H-loop/switch region; other site 1032480003702 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 1032480003703 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1032480003704 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1032480003705 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 1032480003706 Protein of unknown function (DUF817); Region: DUF817; cl01520 1032480003707 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 1032480003708 putative deacylase active site [active] 1032480003709 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480003710 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 1032480003711 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 1032480003712 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480003713 active site 1032480003714 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480003715 active site 1032480003716 ATP binding site [chemical binding]; other site 1032480003717 substrate binding site [chemical binding]; other site 1032480003718 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480003719 Coenzyme A binding pocket [chemical binding]; other site 1032480003720 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1032480003721 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1032480003722 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1032480003723 active site 1032480003724 catalytic residues [active] 1032480003725 metal binding site [ion binding]; metal-binding site 1032480003726 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1032480003727 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1032480003728 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1032480003729 DNA binding site [nucleotide binding] 1032480003730 Int/Topo IB signature motif; other site 1032480003731 active site 1032480003732 Peptidase family M23; Region: Peptidase_M23; pfam01551 1032480003733 Peptidase family M23; Region: Peptidase_M23; pfam01551 1032480003734 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1032480003735 rRNA interaction site [nucleotide binding]; other site 1032480003736 S8 interaction site; other site 1032480003737 putative laminin-1 binding site; other site 1032480003738 elongation factor Ts; Provisional; Region: tsf; PRK09377 1032480003739 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 1032480003740 Elongation factor TS; Region: EF_TS; pfam00889 1032480003741 Elongation factor TS; Region: EF_TS; pfam00889 1032480003742 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1032480003743 putative nucleotide binding site [chemical binding]; other site 1032480003744 uridine monophosphate binding site [chemical binding]; other site 1032480003745 homohexameric interface [polypeptide binding]; other site 1032480003746 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1032480003747 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 1032480003748 hinge region; other site 1032480003749 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 1032480003750 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1032480003751 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1032480003752 FeS/SAM binding site; other site 1032480003753 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1032480003754 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1032480003755 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480003756 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480003757 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480003758 DNA binding site [nucleotide binding] 1032480003759 domain linker motif; other site 1032480003760 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480003761 ligand binding site [chemical binding]; other site 1032480003762 dimerization interface [polypeptide binding]; other site 1032480003763 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1032480003764 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1032480003765 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1032480003766 L-ribulokinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 1032480003767 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1032480003768 putative N- and C-terminal domain interface [polypeptide binding]; other site 1032480003769 putative active site [active] 1032480003770 putative MgATP binding site [chemical binding]; other site 1032480003771 catalytic site [active] 1032480003772 metal binding site [ion binding]; metal-binding site 1032480003773 putative carbohydrate binding site [chemical binding]; other site 1032480003774 L-arabinose isomerase; Provisional; Region: PRK02929 1032480003775 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1032480003776 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1032480003777 trimer interface [polypeptide binding]; other site 1032480003778 putative substrate binding site [chemical binding]; other site 1032480003779 putative metal binding site [ion binding]; other site 1032480003780 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1032480003781 intersubunit interface [polypeptide binding]; other site 1032480003782 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1032480003783 active site 1032480003784 Zn2+ binding site [ion binding]; other site 1032480003785 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480003786 DNA-binding site [nucleotide binding]; DNA binding site 1032480003787 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1032480003788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480003789 dimer interface [polypeptide binding]; other site 1032480003790 conserved gate region; other site 1032480003791 putative PBP binding loops; other site 1032480003792 ABC-ATPase subunit interface; other site 1032480003793 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1032480003794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480003795 dimer interface [polypeptide binding]; other site 1032480003796 putative PBP binding loops; other site 1032480003797 ABC-ATPase subunit interface; other site 1032480003798 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1032480003799 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480003800 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1032480003801 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480003802 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480003803 DNA binding site [nucleotide binding] 1032480003804 domain linker motif; other site 1032480003805 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1032480003806 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1032480003807 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 1032480003808 Cation efflux family; Region: Cation_efflux; cl00316 1032480003809 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1032480003810 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1032480003811 catalytic motif [active] 1032480003812 Zn binding site [ion binding]; other site 1032480003813 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1032480003814 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1032480003815 Lumazine binding domain; Region: Lum_binding; pfam00677 1032480003816 Lumazine binding domain; Region: Lum_binding; pfam00677 1032480003817 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1032480003818 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 1032480003819 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1032480003820 homopentamer interface [polypeptide binding]; other site 1032480003821 active site 1032480003822 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1032480003823 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1032480003824 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1032480003825 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1032480003826 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1032480003827 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1032480003828 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1032480003829 active site 1032480003830 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1032480003831 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 1032480003832 putative substrate binding region [chemical binding]; other site 1032480003833 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1032480003834 putative active site [active] 1032480003835 metal binding site [ion binding]; metal-binding site 1032480003836 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1032480003837 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1032480003838 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1032480003839 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480003840 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480003841 catalytic residue [active] 1032480003842 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1032480003843 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480003844 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480003845 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480003846 active site 1032480003847 ATP binding site [chemical binding]; other site 1032480003848 substrate binding site [chemical binding]; other site 1032480003849 activation loop (A-loop); other site 1032480003850 aminoglycoside resistance protein; Provisional; Region: PRK13746 1032480003851 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1032480003852 active site 1032480003853 NTP binding site [chemical binding]; other site 1032480003854 metal binding triad [ion binding]; metal-binding site 1032480003855 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1032480003856 Integrase core domain; Region: rve; cl01316 1032480003857 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1032480003858 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480003859 Walker A motif; other site 1032480003860 ATP binding site [chemical binding]; other site 1032480003861 Walker B motif; other site 1032480003862 arginine finger; other site 1032480003863 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1032480003864 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1032480003865 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1032480003866 DNA binding residues [nucleotide binding] 1032480003867 dimer interface [polypeptide binding]; other site 1032480003868 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480003869 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1032480003870 active site 1032480003871 metal binding site [ion binding]; metal-binding site 1032480003872 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480003873 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480003874 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1032480003875 homotrimer interaction site [polypeptide binding]; other site 1032480003876 putative active site [active] 1032480003877 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1032480003878 active site 1032480003879 metal binding site [ion binding]; metal-binding site 1032480003880 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1032480003881 Ligand binding site; other site 1032480003882 Putative Catalytic site; other site 1032480003883 DXD motif; other site 1032480003884 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1032480003885 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1032480003886 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1032480003887 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1032480003888 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480003889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480003890 homodimer interface [polypeptide binding]; other site 1032480003891 catalytic residue [active] 1032480003892 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1032480003893 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1032480003894 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1032480003895 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1032480003896 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1032480003897 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480003898 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1032480003899 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 1032480003900 dimer interface [polypeptide binding]; other site 1032480003901 motif 1; other site 1032480003902 active site 1032480003903 motif 2; other site 1032480003904 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1032480003905 putative deacylase active site [active] 1032480003906 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 1032480003907 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1032480003908 anticodon binding site; other site 1032480003909 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 1032480003910 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480003911 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1032480003912 Walker A/P-loop; other site 1032480003913 ATP binding site [chemical binding]; other site 1032480003914 Q-loop/lid; other site 1032480003915 ABC transporter signature motif; other site 1032480003916 Walker B; other site 1032480003917 D-loop; other site 1032480003918 H-loop/switch region; other site 1032480003919 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1032480003920 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1032480003921 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480003922 Walker A/P-loop; other site 1032480003923 ATP binding site [chemical binding]; other site 1032480003924 Q-loop/lid; other site 1032480003925 ABC transporter signature motif; other site 1032480003926 Walker B; other site 1032480003927 D-loop; other site 1032480003928 H-loop/switch region; other site 1032480003929 PQQ-like domain; Region: PQQ_2; pfam13360 1032480003930 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1032480003931 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1032480003932 Sulfatase; Region: Sulfatase; cl10460 1032480003933 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1032480003934 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 1032480003935 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 1032480003936 Sm1 motif; other site 1032480003937 D3 - B interaction site; other site 1032480003938 D1 - D2 interaction site; other site 1032480003939 Hfq - Hfq interaction site; other site 1032480003940 Sm2 motif; other site 1032480003941 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1032480003942 NusA N-terminal domain; Region: NusA_N; pfam08529 1032480003943 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1032480003944 RNA binding site [nucleotide binding]; other site 1032480003945 homodimer interface [polypeptide binding]; other site 1032480003946 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 1032480003947 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1032480003948 G-X-X-G motif; other site 1032480003949 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1032480003950 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 1032480003951 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1032480003952 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1032480003953 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1032480003954 FtsX-like permease family; Region: FtsX; cl15850 1032480003955 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1032480003956 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1032480003957 Walker A/P-loop; other site 1032480003958 ATP binding site [chemical binding]; other site 1032480003959 Q-loop/lid; other site 1032480003960 ABC transporter signature motif; other site 1032480003961 Walker B; other site 1032480003962 D-loop; other site 1032480003963 H-loop/switch region; other site 1032480003964 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1032480003965 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1032480003966 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1032480003967 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480003968 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 1032480003969 putative RNA binding cleft [nucleotide binding]; other site 1032480003970 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1032480003971 translation initiation factor IF-2; Region: IF-2; TIGR00487 1032480003972 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1032480003973 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1032480003974 G1 box; other site 1032480003975 putative GEF interaction site [polypeptide binding]; other site 1032480003976 GTP/Mg2+ binding site [chemical binding]; other site 1032480003977 Switch I region; other site 1032480003978 G2 box; other site 1032480003979 G3 box; other site 1032480003980 Switch II region; other site 1032480003981 G4 box; other site 1032480003982 G5 box; other site 1032480003983 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1032480003984 Translation-initiation factor 2; Region: IF-2; pfam11987 1032480003985 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1032480003986 Arginase family; Region: Arginase; cl00306 1032480003987 Ribosome-binding factor A; Region: RBFA; cl00542 1032480003988 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1032480003989 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 1032480003990 RNA binding site [nucleotide binding]; other site 1032480003991 active site 1032480003992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480003993 S-adenosylmethionine binding site [chemical binding]; other site 1032480003994 HTH-like domain; Region: HTH_21; pfam13276 1032480003995 Integrase core domain; Region: rve; cl01316 1032480003996 Integrase core domain; Region: rve_3; cl15866 1032480003997 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1032480003998 Helix-turn-helix domains; Region: HTH; cl00088 1032480003999 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480004000 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1032480004001 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480004002 DNA binding residues [nucleotide binding] 1032480004003 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1032480004004 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1032480004005 active site 1032480004006 Riboflavin kinase; Region: Flavokinase; cl03312 1032480004007 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1032480004008 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1032480004009 substrate binding site [chemical binding]; other site 1032480004010 ATP binding site [chemical binding]; other site 1032480004011 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1032480004012 16S/18S rRNA binding site [nucleotide binding]; other site 1032480004013 S13e-L30e interaction site [polypeptide binding]; other site 1032480004014 25S rRNA binding site [nucleotide binding]; other site 1032480004015 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1032480004016 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1032480004017 oligomer interface [polypeptide binding]; other site 1032480004018 RNA binding site [nucleotide binding]; other site 1032480004019 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1032480004020 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1032480004021 RNase E interface [polypeptide binding]; other site 1032480004022 trimer interface [polypeptide binding]; other site 1032480004023 active site 1032480004024 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1032480004025 putative nucleic acid binding region [nucleotide binding]; other site 1032480004026 G-X-X-G motif; other site 1032480004027 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1032480004028 RNA binding site [nucleotide binding]; other site 1032480004029 domain interface; other site 1032480004030 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1032480004031 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1032480004032 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1032480004033 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1032480004034 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480004035 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1032480004036 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1032480004037 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 1032480004038 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480004039 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480004040 catalytic residue [active] 1032480004041 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480004042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480004043 active site 1032480004044 phosphorylation site [posttranslational modification] 1032480004045 intermolecular recognition site; other site 1032480004046 dimerization interface [polypeptide binding]; other site 1032480004047 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480004048 DNA binding residues [nucleotide binding] 1032480004049 dimerization interface [polypeptide binding]; other site 1032480004050 Histidine kinase; Region: HisKA_3; pfam07730 1032480004051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1032480004052 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1032480004053 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1032480004054 Walker A/P-loop; other site 1032480004055 ATP binding site [chemical binding]; other site 1032480004056 Q-loop/lid; other site 1032480004057 ABC transporter signature motif; other site 1032480004058 Walker B; other site 1032480004059 D-loop; other site 1032480004060 H-loop/switch region; other site 1032480004061 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1032480004062 phosphoethanolamine N-methyltransferase; Region: PLN02336 1032480004063 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480004064 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480004065 Coenzyme A binding pocket [chemical binding]; other site 1032480004066 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1032480004067 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1032480004068 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1032480004069 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1032480004070 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1032480004071 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480004072 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 1032480004073 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1032480004074 DAK2 domain; Region: Dak2; cl03685 1032480004075 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 1032480004076 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1032480004077 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1032480004078 generic binding surface II; other site 1032480004079 ssDNA binding site; other site 1032480004080 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480004081 ATP binding site [chemical binding]; other site 1032480004082 putative Mg++ binding site [ion binding]; other site 1032480004083 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480004084 nucleotide binding region [chemical binding]; other site 1032480004085 ATP-binding site [chemical binding]; other site 1032480004086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480004087 S-adenosylmethionine binding site [chemical binding]; other site 1032480004088 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1032480004089 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1032480004090 active site 1032480004091 (T/H)XGH motif; other site 1032480004092 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1032480004093 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 1032480004094 ribonuclease III; Reviewed; Region: rnc; PRK00102 1032480004095 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1032480004096 dimerization interface [polypeptide binding]; other site 1032480004097 active site 1032480004098 metal binding site [ion binding]; metal-binding site 1032480004099 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1032480004100 dsRNA binding site [nucleotide binding]; other site 1032480004101 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1032480004102 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1032480004103 DNA binding site [nucleotide binding] 1032480004104 catalytic residue [active] 1032480004105 H2TH interface [polypeptide binding]; other site 1032480004106 putative catalytic residues [active] 1032480004107 turnover-facilitating residue; other site 1032480004108 intercalation triad [nucleotide binding]; other site 1032480004109 8OG recognition residue [nucleotide binding]; other site 1032480004110 putative reading head residues; other site 1032480004111 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1032480004112 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1032480004113 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1032480004114 Helix-turn-helix domains; Region: HTH; cl00088 1032480004115 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480004116 Transposase domain (DUF772); Region: DUF772; cl15789 1032480004117 Transposase domain (DUF772); Region: DUF772; cl15789 1032480004118 GtrA-like protein; Region: GtrA; cl00971 1032480004119 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1032480004120 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 1032480004121 Walker A/P-loop; other site 1032480004122 ATP binding site [chemical binding]; other site 1032480004123 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1032480004124 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 1032480004125 ABC transporter signature motif; other site 1032480004126 Walker B; other site 1032480004127 D-loop; other site 1032480004128 H-loop/switch region; other site 1032480004129 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 1032480004130 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1032480004131 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480004132 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1032480004133 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480004134 NAD(P) binding site [chemical binding]; other site 1032480004135 active site 1032480004136 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1032480004137 Helix-turn-helix domains; Region: HTH; cl00088 1032480004138 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1032480004139 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480004140 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1032480004141 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480004142 Coenzyme A binding pocket [chemical binding]; other site 1032480004143 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480004144 Ligand Binding Site [chemical binding]; other site 1032480004145 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480004146 Ligand Binding Site [chemical binding]; other site 1032480004147 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1032480004148 putative catalytic site [active] 1032480004149 putative metal binding site [ion binding]; other site 1032480004150 putative phosphate binding site [ion binding]; other site 1032480004151 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1032480004152 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480004153 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480004154 catalytic residue [active] 1032480004155 Histidine kinase; Region: HisKA_3; pfam07730 1032480004156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480004157 ATP binding site [chemical binding]; other site 1032480004158 Mg2+ binding site [ion binding]; other site 1032480004159 G-X-G motif; other site 1032480004160 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480004161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480004162 active site 1032480004163 phosphorylation site [posttranslational modification] 1032480004164 intermolecular recognition site; other site 1032480004165 dimerization interface [polypeptide binding]; other site 1032480004166 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480004167 DNA binding residues [nucleotide binding] 1032480004168 dimerization interface [polypeptide binding]; other site 1032480004169 signal recognition particle protein; Provisional; Region: PRK10867 1032480004170 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 1032480004171 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1032480004172 P loop; other site 1032480004173 GTP binding site [chemical binding]; other site 1032480004174 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1032480004175 cytosine deaminase; Provisional; Region: PRK05985 1032480004176 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1032480004177 Amidohydrolase; Region: Amidohydro_4; pfam13147 1032480004178 active site 1032480004179 Predicted acyl esterases [General function prediction only]; Region: COG2936 1032480004180 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480004181 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 1032480004182 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1032480004183 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480004184 Walker A/P-loop; other site 1032480004185 ATP binding site [chemical binding]; other site 1032480004186 Q-loop/lid; other site 1032480004187 ABC transporter signature motif; other site 1032480004188 Walker B; other site 1032480004189 D-loop; other site 1032480004190 H-loop/switch region; other site 1032480004191 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1032480004192 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1032480004193 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480004194 active site 1032480004195 Shikimate kinase; Region: SKI; pfam01202 1032480004196 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 1032480004197 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 1032480004198 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1032480004199 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1032480004200 RimM N-terminal domain; Region: RimM; pfam01782 1032480004201 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 1032480004202 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 1032480004203 Putative esterase; Region: Esterase; pfam00756 1032480004204 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480004205 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1032480004206 active site 1032480004207 catalytic triad [active] 1032480004208 oxyanion hole [active] 1032480004209 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480004210 NAD(P) binding site [chemical binding]; other site 1032480004211 active site 1032480004212 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480004213 S-adenosylmethionine binding site [chemical binding]; other site 1032480004214 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480004215 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1032480004216 Walker A/P-loop; other site 1032480004217 ATP binding site [chemical binding]; other site 1032480004218 Q-loop/lid; other site 1032480004219 ABC transporter signature motif; other site 1032480004220 Walker B; other site 1032480004221 D-loop; other site 1032480004222 H-loop/switch region; other site 1032480004223 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1032480004224 Helix-turn-helix domains; Region: HTH; cl00088 1032480004225 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1032480004226 Predicted ATPase [General function prediction only]; Region: COG3903 1032480004227 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1032480004228 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1032480004229 putative Iron-sulfur protein interface [polypeptide binding]; other site 1032480004230 proximal heme binding site [chemical binding]; other site 1032480004231 distal heme binding site [chemical binding]; other site 1032480004232 putative dimer interface [polypeptide binding]; other site 1032480004233 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1032480004234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480004235 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1032480004236 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1032480004237 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1032480004238 4Fe-4S binding domain; Region: Fer4; cl02805 1032480004239 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1032480004240 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480004241 Walker A/P-loop; other site 1032480004242 ATP binding site [chemical binding]; other site 1032480004243 Q-loop/lid; other site 1032480004244 ABC transporter signature motif; other site 1032480004245 Walker B; other site 1032480004246 D-loop; other site 1032480004247 H-loop/switch region; other site 1032480004248 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1032480004249 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480004250 salt bridge; other site 1032480004251 non-specific DNA binding site [nucleotide binding]; other site 1032480004252 sequence-specific DNA binding site [nucleotide binding]; other site 1032480004253 HipA N-terminal domain; Region: Couple_hipA; cl11853 1032480004254 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 1032480004255 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1032480004256 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1032480004257 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 1032480004258 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1032480004259 Catalytic site [active] 1032480004260 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1032480004261 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1032480004262 Catalytic site [active] 1032480004263 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1032480004264 RNA/DNA hybrid binding site [nucleotide binding]; other site 1032480004265 active site 1032480004266 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1032480004267 Restriction endonuclease; Region: Mrr_cat; cl00516 1032480004268 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1032480004269 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1032480004270 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480004271 Walker A motif; other site 1032480004272 ATP binding site [chemical binding]; other site 1032480004273 Walker B motif; other site 1032480004274 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1032480004275 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1032480004276 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1032480004277 Helix-turn-helix domains; Region: HTH; cl00088 1032480004278 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1032480004279 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1032480004280 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1032480004281 Putative esterase; Region: Esterase; pfam00756 1032480004282 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480004283 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1032480004284 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480004285 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1032480004286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480004287 S-adenosylmethionine binding site [chemical binding]; other site 1032480004288 Dienelactone hydrolase family; Region: DLH; pfam01738 1032480004289 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1032480004290 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1032480004291 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1032480004292 putative active site [active] 1032480004293 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1032480004294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480004295 Y-family of DNA polymerases; Region: PolY; cl12025 1032480004296 active site 1032480004297 DNA binding site [nucleotide binding] 1032480004298 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1032480004299 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 1032480004300 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1032480004301 generic binding surface II; other site 1032480004302 generic binding surface I; other site 1032480004303 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1032480004304 TIR domain; Region: TIR_2; cl15770 1032480004305 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1032480004306 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1032480004307 dimerization interface [polypeptide binding]; other site 1032480004308 DPS ferroxidase diiron center [ion binding]; other site 1032480004309 ion pore; other site 1032480004310 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1032480004311 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1032480004312 NAD(P) binding site [chemical binding]; other site 1032480004313 catalytic residues [active] 1032480004314 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1032480004315 DoxX; Region: DoxX; cl00976 1032480004316 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480004317 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480004318 active site 1032480004319 catalytic tetrad [active] 1032480004320 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1032480004321 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1032480004322 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1032480004323 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1032480004324 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480004325 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480004326 Putative zinc-finger; Region: zf-HC2; cl15806 1032480004327 Bacitracin resistance protein BacA; Region: BacA; cl00858 1032480004328 Flavin Reductases; Region: FlaRed; cl00801 1032480004329 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1032480004330 catalytic core [active] 1032480004331 Protein of unknown function (DUF3090); Region: DUF3090; cl12832 1032480004332 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 1032480004333 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1032480004334 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 1032480004335 active site 1032480004336 HIGH motif; other site 1032480004337 nucleotide binding site [chemical binding]; other site 1032480004338 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1032480004339 active site 1032480004340 KMSKS motif; other site 1032480004341 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1032480004342 tRNA binding surface [nucleotide binding]; other site 1032480004343 anticodon binding site; other site 1032480004344 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 1032480004345 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1032480004346 ATP phosphoribosyltransferase; Region: HisG; cl15266 1032480004347 HisG, C-terminal domain; Region: HisG_C; cl06867 1032480004348 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1032480004349 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1032480004350 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1032480004351 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1032480004352 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 1032480004353 ribosomal protein L20; Region: rpl20; CHL00068 1032480004354 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1032480004355 23S rRNA binding site [nucleotide binding]; other site 1032480004356 L21 binding site [polypeptide binding]; other site 1032480004357 L13 binding site [polypeptide binding]; other site 1032480004358 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 1032480004359 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1032480004360 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1032480004361 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 1032480004362 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1032480004363 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1032480004364 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1032480004365 dimer interface [polypeptide binding]; other site 1032480004366 motif 1; other site 1032480004367 active site 1032480004368 motif 2; other site 1032480004369 motif 3; other site 1032480004370 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1032480004371 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1032480004372 putative tRNA-binding site [nucleotide binding]; other site 1032480004373 B3/4 domain; Region: B3_4; cl11458 1032480004374 tRNA synthetase B5 domain; Region: B5; cl08394 1032480004375 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1032480004376 dimer interface [polypeptide binding]; other site 1032480004377 motif 1; other site 1032480004378 motif 3; other site 1032480004379 motif 2; other site 1032480004380 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 1032480004381 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1032480004382 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480004383 AAA domain; Region: AAA_18; pfam13238 1032480004384 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1032480004385 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480004386 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1032480004387 Uncharacterized conserved protein [Function unknown]; Region: COG3603 1032480004388 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1032480004389 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1032480004390 heterotetramer interface [polypeptide binding]; other site 1032480004391 active site pocket [active] 1032480004392 cleavage site 1032480004393 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1032480004394 feedback inhibition sensing region; other site 1032480004395 homohexameric interface [polypeptide binding]; other site 1032480004396 nucleotide binding site [chemical binding]; other site 1032480004397 N-acetyl-L-glutamate binding site [chemical binding]; other site 1032480004398 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1032480004399 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1032480004400 inhibitor-cofactor binding pocket; inhibition site 1032480004401 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480004402 catalytic residue [active] 1032480004403 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1032480004404 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1032480004405 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480004406 arginine repressor; Provisional; Region: PRK03341 1032480004407 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1032480004408 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1032480004409 argininosuccinate lyase; Provisional; Region: PRK00855 1032480004410 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1032480004411 active sites [active] 1032480004412 tetramer interface [polypeptide binding]; other site 1032480004413 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1032480004414 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1032480004415 active site 1032480004416 HIGH motif; other site 1032480004417 dimer interface [polypeptide binding]; other site 1032480004418 KMSKS motif; other site 1032480004419 potential protein location (hypothetical protein MLP_17290 [Microlunatus phosphovorus NM-1]) that overlaps RNA (23S ribosomal RNA) 1032480004420 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1032480004421 Helix-turn-helix domains; Region: HTH; cl00088 1032480004422 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1032480004423 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1032480004424 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 1032480004425 putative NAD(P) binding site [chemical binding]; other site 1032480004426 catalytic Zn binding site [ion binding]; other site 1032480004427 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1032480004428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480004429 dimer interface [polypeptide binding]; other site 1032480004430 conserved gate region; other site 1032480004431 putative PBP binding loops; other site 1032480004432 ABC-ATPase subunit interface; other site 1032480004433 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1032480004434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480004435 dimer interface [polypeptide binding]; other site 1032480004436 putative PBP binding loops; other site 1032480004437 ABC-ATPase subunit interface; other site 1032480004438 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1032480004439 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480004440 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1032480004441 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1032480004442 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1032480004443 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480004444 active site 1032480004445 motif I; other site 1032480004446 motif II; other site 1032480004447 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1032480004448 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1032480004449 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1032480004450 active site 1032480004451 catalytic site [active] 1032480004452 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1032480004453 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1032480004454 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1032480004455 RNA binding surface [nucleotide binding]; other site 1032480004456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 1032480004457 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1032480004458 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 1032480004459 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1032480004460 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 1032480004461 Walker A/P-loop; other site 1032480004462 ATP binding site [chemical binding]; other site 1032480004463 Q-loop/lid; other site 1032480004464 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 1032480004465 ABC transporter signature motif; other site 1032480004466 Walker B; other site 1032480004467 D-loop; other site 1032480004468 H-loop/switch region; other site 1032480004469 transcription termination factor Rho; Provisional; Region: PRK12678 1032480004470 CTP synthetase; Validated; Region: pyrG; PRK05380 1032480004471 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1032480004472 Catalytic site [active] 1032480004473 active site 1032480004474 UTP binding site [chemical binding]; other site 1032480004475 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1032480004476 active site 1032480004477 putative oxyanion hole; other site 1032480004478 catalytic triad [active] 1032480004479 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1032480004480 dimer interface [polypeptide binding]; other site 1032480004481 ADP-ribose binding site [chemical binding]; other site 1032480004482 active site 1032480004483 nudix motif; other site 1032480004484 metal binding site [ion binding]; metal-binding site 1032480004485 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 1032480004486 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1032480004487 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 1032480004488 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480004489 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1032480004490 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1032480004491 Int/Topo IB signature motif; other site 1032480004492 active site 1032480004493 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1032480004494 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1032480004495 P-loop; other site 1032480004496 Magnesium ion binding site [ion binding]; other site 1032480004497 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1032480004498 Magnesium ion binding site [ion binding]; other site 1032480004499 ScpA/B protein; Region: ScpA_ScpB; cl00598 1032480004500 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 1032480004501 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1032480004502 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1032480004503 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 1032480004504 active site 1032480004505 Pup-ligase protein; Region: Pup_ligase; cl15463 1032480004506 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 1032480004507 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 1032480004508 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 1032480004509 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1032480004510 active site 1032480004511 HIGH motif; other site 1032480004512 nucleotide binding site [chemical binding]; other site 1032480004513 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1032480004514 active site 1032480004515 KMSKS motif; other site 1032480004516 Predicted transcriptional regulator [Transcription]; Region: COG2378 1032480004517 WYL domain; Region: WYL; cl14852 1032480004518 Predicted transcriptional regulator [Transcription]; Region: COG2378 1032480004519 WYL domain; Region: WYL; cl14852 1032480004520 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1032480004521 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1032480004522 diacylglycerol kinase; Reviewed; Region: PRK11914 1032480004523 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1032480004524 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1032480004525 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480004526 ATP binding site [chemical binding]; other site 1032480004527 putative Mg++ binding site [ion binding]; other site 1032480004528 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480004529 nucleotide binding region [chemical binding]; other site 1032480004530 ATP-binding site [chemical binding]; other site 1032480004531 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1032480004532 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480004533 S-adenosylmethionine binding site [chemical binding]; other site 1032480004534 TPR repeat; Region: TPR_11; pfam13414 1032480004535 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480004536 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480004537 DNA binding residues [nucleotide binding] 1032480004538 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1032480004539 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1032480004540 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1032480004541 tetramer interface [polypeptide binding]; other site 1032480004542 active site 1032480004543 Mg2+/Mn2+ binding site [ion binding]; other site 1032480004544 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 1032480004545 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 1032480004546 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 1032480004547 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1032480004548 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1032480004549 DNA binding residues [nucleotide binding] 1032480004550 B12 binding domain; Region: B12-binding_2; cl03653 1032480004551 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1032480004552 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1032480004553 active site 1032480004554 metal binding site [ion binding]; metal-binding site 1032480004555 nudix motif; other site 1032480004556 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1032480004557 substrate binding pocket [chemical binding]; other site 1032480004558 chain length determination region; other site 1032480004559 substrate-Mg2+ binding site; other site 1032480004560 catalytic residues [active] 1032480004561 aspartate-rich region 1; other site 1032480004562 active site lid residues [active] 1032480004563 aspartate-rich region 2; other site 1032480004564 phytoene desaturase; Region: crtI_fam; TIGR02734 1032480004565 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480004566 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1032480004567 active site lid residues [active] 1032480004568 substrate binding pocket [chemical binding]; other site 1032480004569 catalytic residues [active] 1032480004570 substrate-Mg2+ binding site; other site 1032480004571 aspartate-rich region 1; other site 1032480004572 aspartate-rich region 2; other site 1032480004573 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1032480004574 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480004575 Helix-turn-helix domains; Region: HTH; cl00088 1032480004576 putative transposase OrfB; Reviewed; Region: PHA02517 1032480004577 HTH-like domain; Region: HTH_21; pfam13276 1032480004578 Integrase core domain; Region: rve; cl01316 1032480004579 Integrase core domain; Region: rve_3; cl15866 1032480004580 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1032480004581 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480004582 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1032480004583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480004584 S-adenosylmethionine binding site [chemical binding]; other site 1032480004585 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480004586 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1032480004587 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1032480004588 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1032480004589 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1032480004590 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1032480004591 substrate binding site [chemical binding]; other site 1032480004592 glutamase interaction surface [polypeptide binding]; other site 1032480004593 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1032480004594 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480004595 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1032480004596 HIT family signature motif; other site 1032480004597 catalytic residue [active] 1032480004598 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1032480004599 Dehydratase family; Region: ILVD_EDD; cl00340 1032480004600 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1032480004601 PLD-like domain; Region: PLDc_2; pfam13091 1032480004602 putative active site [active] 1032480004603 catalytic site [active] 1032480004604 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1032480004605 PLD-like domain; Region: PLDc_2; pfam13091 1032480004606 putative active site [active] 1032480004607 catalytic site [active] 1032480004608 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1032480004609 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1032480004610 active site 1032480004611 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1032480004612 putative dimer interface [polypeptide binding]; other site 1032480004613 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480004614 Helix-turn-helix domain; Region: HTH_18; pfam12833 1032480004615 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480004616 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1032480004617 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1032480004618 putative active site [active] 1032480004619 putative metal binding site [ion binding]; other site 1032480004620 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1032480004621 metal binding site [ion binding]; metal-binding site 1032480004622 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1032480004623 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1032480004624 PYR/PP interface [polypeptide binding]; other site 1032480004625 dimer interface [polypeptide binding]; other site 1032480004626 TPP binding site [chemical binding]; other site 1032480004627 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1032480004628 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1032480004629 TPP-binding site [chemical binding]; other site 1032480004630 dimer interface [polypeptide binding]; other site 1032480004631 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1032480004632 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1032480004633 putative valine binding site [chemical binding]; other site 1032480004634 dimer interface [polypeptide binding]; other site 1032480004635 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1032480004636 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1032480004637 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480004638 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1032480004639 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480004640 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1032480004641 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1032480004642 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1032480004643 homodimer interface [polypeptide binding]; other site 1032480004644 substrate-cofactor binding pocket; other site 1032480004645 catalytic residue [active] 1032480004646 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 1032480004647 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 1032480004648 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 1032480004649 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 1032480004650 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1032480004651 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 1032480004652 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 1032480004653 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1032480004654 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1032480004655 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1032480004656 NAD binding site [chemical binding]; other site 1032480004657 dimerization interface [polypeptide binding]; other site 1032480004658 product binding site; other site 1032480004659 substrate binding site [chemical binding]; other site 1032480004660 zinc binding site [ion binding]; other site 1032480004661 catalytic residues [active] 1032480004662 Helix-turn-helix domains; Region: HTH; cl00088 1032480004663 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 1032480004664 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1032480004665 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1032480004666 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1032480004667 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1032480004668 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1032480004669 Walker A/P-loop; other site 1032480004670 ATP binding site [chemical binding]; other site 1032480004671 Q-loop/lid; other site 1032480004672 ABC transporter signature motif; other site 1032480004673 Walker B; other site 1032480004674 D-loop; other site 1032480004675 H-loop/switch region; other site 1032480004676 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1032480004677 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1032480004678 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1032480004679 Walker A/P-loop; other site 1032480004680 ATP binding site [chemical binding]; other site 1032480004681 Q-loop/lid; other site 1032480004682 ABC transporter signature motif; other site 1032480004683 Walker B; other site 1032480004684 D-loop; other site 1032480004685 H-loop/switch region; other site 1032480004686 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1032480004687 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480004688 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480004689 dimerization interface [polypeptide binding]; other site 1032480004690 putative DNA binding site [nucleotide binding]; other site 1032480004691 putative Zn2+ binding site [ion binding]; other site 1032480004692 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1032480004693 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 1032480004694 Walker A/P-loop; other site 1032480004695 ATP binding site [chemical binding]; other site 1032480004696 Q-loop/lid; other site 1032480004697 ABC transporter signature motif; other site 1032480004698 Walker B; other site 1032480004699 D-loop; other site 1032480004700 H-loop/switch region; other site 1032480004701 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480004702 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1032480004703 Walker A/P-loop; other site 1032480004704 ATP binding site [chemical binding]; other site 1032480004705 Q-loop/lid; other site 1032480004706 ABC transporter signature motif; other site 1032480004707 Walker B; other site 1032480004708 D-loop; other site 1032480004709 H-loop/switch region; other site 1032480004710 Cobalt transport protein; Region: CbiQ; cl00463 1032480004711 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 1032480004712 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 1032480004713 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1032480004714 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480004715 Walker A/P-loop; other site 1032480004716 ATP binding site [chemical binding]; other site 1032480004717 Q-loop/lid; other site 1032480004718 ABC transporter signature motif; other site 1032480004719 Walker B; other site 1032480004720 D-loop; other site 1032480004721 H-loop/switch region; other site 1032480004722 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1032480004723 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1032480004724 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480004725 Walker A/P-loop; other site 1032480004726 ATP binding site [chemical binding]; other site 1032480004727 Q-loop/lid; other site 1032480004728 ABC transporter signature motif; other site 1032480004729 Walker B; other site 1032480004730 D-loop; other site 1032480004731 H-loop/switch region; other site 1032480004732 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1032480004733 Helix-turn-helix domains; Region: HTH; cl00088 1032480004734 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 1032480004735 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 1032480004736 active site 1032480004737 catalytic residues [active] 1032480004738 metal binding site [ion binding]; metal-binding site 1032480004739 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 1032480004740 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1032480004741 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1032480004742 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480004743 Walker A/P-loop; other site 1032480004744 ATP binding site [chemical binding]; other site 1032480004745 Q-loop/lid; other site 1032480004746 ABC transporter signature motif; other site 1032480004747 Walker B; other site 1032480004748 D-loop; other site 1032480004749 H-loop/switch region; other site 1032480004750 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1032480004751 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1032480004752 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1032480004753 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1032480004754 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1032480004755 HIGH motif; other site 1032480004756 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1032480004757 active site 1032480004758 KMSKS motif; other site 1032480004759 CAAX protease self-immunity; Region: Abi; cl00558 1032480004760 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1032480004761 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480004762 DNA-binding site [nucleotide binding]; DNA binding site 1032480004763 FCD domain; Region: FCD; cl11656 1032480004764 ethanolamine permease; Region: 2A0305; TIGR00908 1032480004765 Spore germination protein; Region: Spore_permease; cl15802 1032480004766 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1032480004767 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1032480004768 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1032480004769 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1032480004770 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1032480004771 NAD(P) binding site [chemical binding]; other site 1032480004772 catalytic residues [active] 1032480004773 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1032480004774 classical (c) SDRs; Region: SDR_c; cd05233 1032480004775 NAD(P) binding site [chemical binding]; other site 1032480004776 active site 1032480004777 Sulfatase; Region: Sulfatase; cl10460 1032480004778 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1032480004779 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1032480004780 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480004781 Walker A/P-loop; other site 1032480004782 ATP binding site [chemical binding]; other site 1032480004783 Q-loop/lid; other site 1032480004784 ABC transporter signature motif; other site 1032480004785 Walker B; other site 1032480004786 D-loop; other site 1032480004787 H-loop/switch region; other site 1032480004788 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1032480004789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1032480004790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1032480004791 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480004792 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1032480004793 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1032480004794 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480004795 motif II; other site 1032480004796 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1032480004797 Helix-turn-helix domains; Region: HTH; cl00088 1032480004798 DNA-binding site [nucleotide binding]; DNA binding site 1032480004799 UTRA domain; Region: UTRA; cl01230 1032480004800 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1032480004801 Int/Topo IB signature motif; other site 1032480004802 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1032480004803 short chain dehydrogenase; Validated; Region: PRK08324 1032480004804 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1032480004805 Helix-turn-helix domains; Region: HTH; cl00088 1032480004806 HTH-like domain; Region: HTH_21; pfam13276 1032480004807 Integrase core domain; Region: rve; cl01316 1032480004808 Integrase core domain; Region: rve_3; cl15866 1032480004809 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 1032480004810 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1032480004811 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480004812 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1032480004813 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480004814 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1032480004815 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1032480004816 active site 1032480004817 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1032480004818 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480004819 AAA domain; Region: AAA_33; pfam13671 1032480004820 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1032480004821 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1032480004822 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480004823 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1032480004824 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480004825 potential frameshift: common BLAST hit: gi|111025755|ref|YP_708175.1| TnpB family transposase 1032480004826 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1032480004827 Integrase core domain; Region: rve; cl01316 1032480004828 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1032480004829 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480004830 Helix-turn-helix domains; Region: HTH; cl00088 1032480004831 Helix-turn-helix domains; Region: HTH; cl00088 1032480004832 Integrase core domain; Region: rve; cl01316 1032480004833 Integrase core domain; Region: rve_3; cl15866 1032480004834 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1032480004835 Helix-turn-helix domains; Region: HTH; cl00088 1032480004836 putative transposase OrfB; Reviewed; Region: PHA02517 1032480004837 HTH-like domain; Region: HTH_21; pfam13276 1032480004838 Integrase core domain; Region: rve; cl01316 1032480004839 Integrase core domain; Region: rve_3; cl15866 1032480004840 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1032480004841 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480004842 putative transposase OrfB; Reviewed; Region: PHA02517 1032480004843 HTH-like domain; Region: HTH_21; pfam13276 1032480004844 Integrase core domain; Region: rve; cl01316 1032480004845 Integrase core domain; Region: rve_3; cl15866 1032480004846 Helix-turn-helix domains; Region: HTH; cl00088 1032480004847 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 1032480004848 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1032480004849 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1032480004850 putative active site [active] 1032480004851 putative NTP binding site [chemical binding]; other site 1032480004852 putative nucleic acid binding site [nucleotide binding]; other site 1032480004853 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1032480004854 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1032480004855 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 1032480004856 Protein of unknown function DUF262; Region: DUF262; cl14890 1032480004857 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480004858 Tannase and feruloyl esterase; Region: Tannase; pfam07519 1032480004859 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1032480004860 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480004861 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480004862 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1032480004863 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480004864 DNA binding residues [nucleotide binding] 1032480004865 dimerization interface [polypeptide binding]; other site 1032480004866 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480004867 Predicted ATPase [General function prediction only]; Region: COG3899 1032480004868 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480004869 DNA binding residues [nucleotide binding] 1032480004870 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480004871 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1032480004872 hydrophobic ligand binding site; other site 1032480004873 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1032480004874 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1032480004875 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1032480004876 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1032480004877 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 1032480004878 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1032480004879 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480004880 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1032480004881 FAD binding domain; Region: FAD_binding_4; pfam01565 1032480004882 Berberine and berberine like; Region: BBE; pfam08031 1032480004883 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480004884 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480004885 DNA binding residues [nucleotide binding] 1032480004886 dimerization interface [polypeptide binding]; other site 1032480004887 choline dehydrogenase; Validated; Region: PRK02106 1032480004888 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1032480004889 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 1032480004890 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1032480004891 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1032480004892 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 1032480004893 putative dimer interface [polypeptide binding]; other site 1032480004894 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480004895 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1032480004896 active site 1032480004897 8-oxo-dGMP binding site [chemical binding]; other site 1032480004898 nudix motif; other site 1032480004899 metal binding site [ion binding]; metal-binding site 1032480004900 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1032480004901 putative active site [active] 1032480004902 catalytic site [active] 1032480004903 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 1032480004904 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480004905 ATP binding site [chemical binding]; other site 1032480004906 putative Mg++ binding site [ion binding]; other site 1032480004907 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480004908 nucleotide binding region [chemical binding]; other site 1032480004909 ATP-binding site [chemical binding]; other site 1032480004910 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1032480004911 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 1032480004912 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480004913 Walker A/P-loop; other site 1032480004914 ATP binding site [chemical binding]; other site 1032480004915 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1032480004916 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1032480004917 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 1032480004918 FAD binding domain; Region: FAD_binding_4; pfam01565 1032480004919 Berberine and berberine like; Region: BBE; pfam08031 1032480004920 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480004921 DNA binding residues [nucleotide binding] 1032480004922 dimerization interface [polypeptide binding]; other site 1032480004923 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 1032480004924 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480004925 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1032480004926 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480004927 YCII-related domain; Region: YCII; cl00999 1032480004928 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1032480004929 active site 1032480004930 metal binding site [ion binding]; metal-binding site 1032480004931 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480004932 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 1032480004933 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480004934 S-adenosylmethionine binding site [chemical binding]; other site 1032480004935 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1032480004936 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1032480004937 Ca binding site [ion binding]; other site 1032480004938 active site 1032480004939 catalytic site [active] 1032480004940 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1032480004941 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1032480004942 Cupin domain; Region: Cupin_2; cl09118 1032480004943 Helix-turn-helix domains; Region: HTH; cl00088 1032480004944 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1032480004945 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480004946 Coenzyme A binding pocket [chemical binding]; other site 1032480004947 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1032480004948 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1032480004949 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1032480004950 putative di-iron ligands [ion binding]; other site 1032480004951 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1032480004952 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1032480004953 FAD binding pocket [chemical binding]; other site 1032480004954 FAD binding motif [chemical binding]; other site 1032480004955 phosphate binding motif [ion binding]; other site 1032480004956 beta-alpha-beta structure motif; other site 1032480004957 NAD binding pocket [chemical binding]; other site 1032480004958 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1032480004959 catalytic loop [active] 1032480004960 iron binding site [ion binding]; other site 1032480004961 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1032480004962 Helix-turn-helix domains; Region: HTH; cl00088 1032480004963 TIGR03085 family protein; Region: TIGR03085 1032480004964 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1032480004965 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1032480004966 active site 1032480004967 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1032480004968 phenylalanine transporter; Provisional; Region: PRK10249 1032480004969 Spore germination protein; Region: Spore_permease; cl15802 1032480004970 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1032480004971 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1032480004972 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480004973 DNA binding residues [nucleotide binding] 1032480004974 dimerization interface [polypeptide binding]; other site 1032480004975 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1032480004976 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1032480004977 AMP binding site [chemical binding]; other site 1032480004978 metal binding site [ion binding]; metal-binding site 1032480004979 active site 1032480004980 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 1032480004981 active site 1032480004982 haloacid dehalogenase-like hydrolase family protein; Region: PLN02779 1032480004983 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1032480004984 motif I; other site 1032480004985 active site 1032480004986 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480004987 motif II; other site 1032480004988 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1032480004989 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1032480004990 substrate binding site [chemical binding]; other site 1032480004991 hexamer interface [polypeptide binding]; other site 1032480004992 metal binding site [ion binding]; metal-binding site 1032480004993 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480004994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480004995 active site 1032480004996 phosphorylation site [posttranslational modification] 1032480004997 intermolecular recognition site; other site 1032480004998 dimerization interface [polypeptide binding]; other site 1032480004999 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480005000 DNA binding residues [nucleotide binding] 1032480005001 dimerization interface [polypeptide binding]; other site 1032480005002 GAF domain; Region: GAF; cl15785 1032480005003 Histidine kinase; Region: HisKA_3; pfam07730 1032480005004 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480005005 ATP binding site [chemical binding]; other site 1032480005006 Mg2+ binding site [ion binding]; other site 1032480005007 G-X-G motif; other site 1032480005008 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1032480005009 catalytic residue [active] 1032480005010 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480005011 dimerization interface [polypeptide binding]; other site 1032480005012 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 1032480005013 multimerization interface [polypeptide binding]; other site 1032480005014 probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880 1032480005015 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480005016 Walker A motif; other site 1032480005017 ATP binding site [chemical binding]; other site 1032480005018 Walker B motif; other site 1032480005019 arginine finger; other site 1032480005020 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1032480005021 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1032480005022 putative molybdopterin cofactor binding site [chemical binding]; other site 1032480005023 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1032480005024 putative molybdopterin cofactor binding site; other site 1032480005025 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 1032480005026 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 1032480005027 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1032480005028 Helix-turn-helix domains; Region: HTH; cl00088 1032480005029 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1032480005030 dimerization interface [polypeptide binding]; other site 1032480005031 formate dehydrogenase; Provisional; Region: PRK07574 1032480005032 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480005033 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480005034 sequence-specific DNA binding site [nucleotide binding]; other site 1032480005035 salt bridge; other site 1032480005036 Cupin domain; Region: Cupin_2; cl09118 1032480005037 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1032480005038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480005039 S-adenosylmethionine binding site [chemical binding]; other site 1032480005040 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1032480005041 IHF dimer interface [polypeptide binding]; other site 1032480005042 IHF - DNA interface [nucleotide binding]; other site 1032480005043 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1032480005044 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 1032480005045 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1032480005046 dimer interface [polypeptide binding]; other site 1032480005047 NADP binding site [chemical binding]; other site 1032480005048 catalytic residues [active] 1032480005049 Winged helix-turn helix; Region: HTH_29; pfam13551 1032480005050 Integrase core domain; Region: rve; cl01316 1032480005051 Integrase core domain; Region: rve_3; cl15866 1032480005052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480005053 metabolite-proton symporter; Region: 2A0106; TIGR00883 1032480005054 putative substrate translocation pore; other site 1032480005055 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1032480005056 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480005057 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1032480005058 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1032480005059 potential frameshift: common BLAST hit: gi|111020279|ref|YP_703251.1| aspartate aminotransferase 1032480005060 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480005061 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480005062 homodimer interface [polypeptide binding]; other site 1032480005063 catalytic residue [active] 1032480005064 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480005065 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1032480005066 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480005067 NAD(P) binding site [chemical binding]; other site 1032480005068 active site 1032480005069 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 1032480005070 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1032480005071 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1032480005072 LamB/YcsF family; Region: LamB_YcsF; cl00664 1032480005073 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1032480005074 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1032480005075 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1032480005076 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1032480005077 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1032480005078 carboxyltransferase (CT) interaction site; other site 1032480005079 biotinylation site [posttranslational modification]; other site 1032480005080 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 1032480005081 Helix-turn-helix domains; Region: HTH; cl00088 1032480005082 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1032480005083 putative dimerization interface [polypeptide binding]; other site 1032480005084 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 1032480005085 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1032480005086 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1032480005087 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1032480005088 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1032480005089 GAF domain; Region: GAF; cl15785 1032480005090 GAF domain; Region: GAF_2; pfam13185 1032480005091 GAF domain; Region: GAF; cl15785 1032480005092 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1032480005093 Histidine kinase; Region: HisKA_3; pfam07730 1032480005094 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480005095 Ligand Binding Site [chemical binding]; other site 1032480005096 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480005097 Ligand Binding Site [chemical binding]; other site 1032480005098 Helix-turn-helix domains; Region: HTH; cl00088 1032480005099 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1032480005100 putative dimerization interface [polypeptide binding]; other site 1032480005101 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1032480005102 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; cl14733 1032480005103 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1032480005104 choline dehydrogenase; Validated; Region: PRK02106 1032480005105 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480005106 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1032480005107 FAD dependent oxidoreductase; Region: DAO; pfam01266 1032480005108 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1032480005109 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1032480005110 inhibitor site; inhibition site 1032480005111 active site 1032480005112 dimer interface [polypeptide binding]; other site 1032480005113 catalytic residue [active] 1032480005114 GAF domain; Region: GAF; cl15785 1032480005115 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1032480005116 NAD(P) binding site [chemical binding]; other site 1032480005117 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1032480005118 catalytic residues [active] 1032480005119 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1032480005120 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1032480005121 NADP binding site [chemical binding]; other site 1032480005122 dimer interface [polypeptide binding]; other site 1032480005123 Helix-turn-helix domains; Region: HTH; cl00088 1032480005124 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1032480005125 Helix-turn-helix domains; Region: HTH; cl00088 1032480005126 AzlC protein; Region: AzlC; cl00570 1032480005127 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1032480005128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480005129 metabolite-proton symporter; Region: 2A0106; TIGR00883 1032480005130 putative substrate translocation pore; other site 1032480005131 Protein of unknown function (DUF1345); Region: DUF1345; cl01753 1032480005132 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1032480005133 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480005134 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1032480005135 Family description; Region: UvrD_C_2; cl15862 1032480005136 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 1032480005137 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1032480005138 putative active cleft [active] 1032480005139 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480005140 Coenzyme A binding pocket [chemical binding]; other site 1032480005141 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1032480005142 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1032480005143 RES domain; Region: RES; cl02411 1032480005144 Ribosomal protein L20; Region: Ribosomal_L20; cl00393 1032480005145 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1032480005146 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1032480005147 inhibitor binding site; inhibition site 1032480005148 catalytic Zn binding site [ion binding]; other site 1032480005149 structural Zn binding site [ion binding]; other site 1032480005150 NADP binding site [chemical binding]; other site 1032480005151 tetramer interface [polypeptide binding]; other site 1032480005152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480005153 metabolite-proton symporter; Region: 2A0106; TIGR00883 1032480005154 putative substrate translocation pore; other site 1032480005155 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1032480005156 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1032480005157 Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea; Region: Creatinase; cd01090 1032480005158 active site 1032480005159 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1032480005160 Helix-turn-helix domains; Region: HTH; cl00088 1032480005161 Bacterial transcriptional regulator; Region: IclR; pfam01614 1032480005162 Scramblase; Region: Scramblase; cl02043 1032480005163 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1032480005164 RNA/DNA hybrid binding site [nucleotide binding]; other site 1032480005165 active site 1032480005166 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1032480005167 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480005168 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1032480005169 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1032480005170 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1032480005171 active site 1032480005172 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1032480005173 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1032480005174 [2Fe-2S] cluster binding site [ion binding]; other site 1032480005175 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 1032480005176 putative alpha subunit interface [polypeptide binding]; other site 1032480005177 putative active site [active] 1032480005178 putative substrate binding site [chemical binding]; other site 1032480005179 Fe binding site [ion binding]; other site 1032480005180 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1032480005181 Helix-turn-helix domains; Region: HTH; cl00088 1032480005182 Bacterial transcriptional regulator; Region: IclR; pfam01614 1032480005183 citrate synthase; Provisional; Region: PRK14033 1032480005184 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1032480005185 oxalacetate binding site [chemical binding]; other site 1032480005186 citrylCoA binding site [chemical binding]; other site 1032480005187 coenzyme A binding site [chemical binding]; other site 1032480005188 catalytic triad [active] 1032480005189 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 1032480005190 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1032480005191 tetramer interface [polypeptide binding]; other site 1032480005192 active site 1032480005193 Mg2+/Mn2+ binding site [ion binding]; other site 1032480005194 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1032480005195 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1032480005196 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480005197 DNA-binding site [nucleotide binding]; DNA binding site 1032480005198 FCD domain; Region: FCD; cl11656 1032480005199 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480005200 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1032480005201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480005202 dimer interface [polypeptide binding]; other site 1032480005203 conserved gate region; other site 1032480005204 putative PBP binding loops; other site 1032480005205 ABC-ATPase subunit interface; other site 1032480005206 sulfate transport protein; Provisional; Region: cysT; CHL00187 1032480005207 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480005208 dimer interface [polypeptide binding]; other site 1032480005209 conserved gate region; other site 1032480005210 putative PBP binding loops; other site 1032480005211 ABC-ATPase subunit interface; other site 1032480005212 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296 1032480005213 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1032480005214 Walker A/P-loop; other site 1032480005215 ATP binding site [chemical binding]; other site 1032480005216 Q-loop/lid; other site 1032480005217 ABC transporter signature motif; other site 1032480005218 Walker B; other site 1032480005219 D-loop; other site 1032480005220 H-loop/switch region; other site 1032480005221 TOBE-like domain; Region: TOBE_3; pfam12857 1032480005222 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 1032480005223 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1032480005224 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1032480005225 Glycerate kinase family; Region: Gly_kinase; cl00841 1032480005226 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480005227 Ligand Binding Site [chemical binding]; other site 1032480005228 synaptic vesicle protein SV2; Region: synapt_SV2; TIGR01299 1032480005229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480005230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480005231 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1032480005232 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1032480005233 substrate binding pocket [chemical binding]; other site 1032480005234 membrane-bound complex binding site; other site 1032480005235 hinge residues; other site 1032480005236 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1032480005237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480005238 dimer interface [polypeptide binding]; other site 1032480005239 conserved gate region; other site 1032480005240 putative PBP binding loops; other site 1032480005241 ABC-ATPase subunit interface; other site 1032480005242 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1032480005243 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1032480005244 Walker A/P-loop; other site 1032480005245 ATP binding site [chemical binding]; other site 1032480005246 Q-loop/lid; other site 1032480005247 ABC transporter signature motif; other site 1032480005248 Walker B; other site 1032480005249 D-loop; other site 1032480005250 H-loop/switch region; other site 1032480005251 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1032480005252 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1032480005253 DNA binding residues [nucleotide binding] 1032480005254 short chain dehydrogenase; Provisional; Region: PRK06701 1032480005255 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480005256 NAD(P) binding site [chemical binding]; other site 1032480005257 active site 1032480005258 GAF domain; Region: GAF; cl15785 1032480005259 GAF domain; Region: GAF_2; pfam13185 1032480005260 ANTAR domain; Region: ANTAR; cl04297 1032480005261 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1032480005262 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1032480005263 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480005264 ChaB; Region: ChaB; cl01887 1032480005265 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1032480005266 putative catalytic site [active] 1032480005267 putative metal binding site [ion binding]; other site 1032480005268 putative phosphate binding site [ion binding]; other site 1032480005269 BCCT family transporter; Region: BCCT; cl00569 1032480005270 choline dehydrogenase; Validated; Region: PRK02106 1032480005271 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1032480005272 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1032480005273 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1032480005274 NAD(P) binding site [chemical binding]; other site 1032480005275 catalytic residues [active] 1032480005276 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480005277 DNA-binding site [nucleotide binding]; DNA binding site 1032480005278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1032480005279 Helix-turn-helix domains; Region: HTH; cl00088 1032480005280 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1032480005281 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1032480005282 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480005283 DNA-binding site [nucleotide binding]; DNA binding site 1032480005284 FCD domain; Region: FCD; cl11656 1032480005285 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1032480005286 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1032480005287 dimer interface [polypeptide binding]; other site 1032480005288 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1032480005289 active site 1032480005290 folate binding site [chemical binding]; other site 1032480005291 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 1032480005292 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480005293 Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767 1032480005294 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 1032480005295 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1032480005296 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1032480005297 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1032480005298 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1032480005299 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1032480005300 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1032480005301 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 1032480005302 Uncharacterized conserved protein [Function unknown]; Region: COG4850 1032480005303 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 1032480005304 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1032480005305 Helix-turn-helix domains; Region: HTH; cl00088 1032480005306 Bacterial transcriptional regulator; Region: IclR; pfam01614 1032480005307 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1032480005308 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1032480005309 substrate binding site [chemical binding]; other site 1032480005310 ligand binding site [chemical binding]; other site 1032480005311 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1032480005312 substrate binding site [chemical binding]; other site 1032480005313 putative transposase OrfB; Reviewed; Region: PHA02517 1032480005314 Integrase core domain; Region: rve; cl01316 1032480005315 Integrase core domain; Region: rve_3; cl15866 1032480005316 cell division protein GpsB; Provisional; Region: PRK14127 1032480005317 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1032480005318 IHF - DNA interface [nucleotide binding]; other site 1032480005319 IHF dimer interface [polypeptide binding]; other site 1032480005320 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1032480005321 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1032480005322 putative acyl-acceptor binding pocket; other site 1032480005323 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1032480005324 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480005325 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1032480005326 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1032480005327 DinB superfamily; Region: DinB_2; pfam12867 1032480005328 YCII-related domain; Region: YCII; cl00999 1032480005329 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1032480005330 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1032480005331 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1032480005332 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480005333 cystathionine gamma-lyase; Validated; Region: PRK07582 1032480005334 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480005335 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480005336 catalytic residue [active] 1032480005337 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1032480005338 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1032480005339 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1032480005340 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1032480005341 active site 1032480005342 metal binding site [ion binding]; metal-binding site 1032480005343 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1032480005344 Helix-turn-helix domains; Region: HTH; cl00088 1032480005345 thiamine monophosphate kinase; Provisional; Region: PRK05731 1032480005346 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1032480005347 ATP binding site [chemical binding]; other site 1032480005348 dimerization interface [polypeptide binding]; other site 1032480005349 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1032480005350 dimer interface [polypeptide binding]; other site 1032480005351 substrate binding site [chemical binding]; other site 1032480005352 ATP binding site [chemical binding]; other site 1032480005353 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1032480005354 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1032480005355 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480005356 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 1032480005357 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 1032480005358 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1032480005359 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1032480005360 FeS/SAM binding site; other site 1032480005361 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1032480005362 Competence-damaged protein; Region: CinA; cl00666 1032480005363 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480005364 non-specific DNA binding site [nucleotide binding]; other site 1032480005365 salt bridge; other site 1032480005366 sequence-specific DNA binding site [nucleotide binding]; other site 1032480005367 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480005368 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1032480005369 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480005370 DNA binding residues [nucleotide binding] 1032480005371 dimerization interface [polypeptide binding]; other site 1032480005372 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1032480005373 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480005374 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480005375 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1032480005376 ATP binding site [chemical binding]; other site 1032480005377 putative Mg++ binding site [ion binding]; other site 1032480005378 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480005379 nucleotide binding region [chemical binding]; other site 1032480005380 ATP-binding site [chemical binding]; other site 1032480005381 DEAD/H associated; Region: DEAD_assoc; pfam08494 1032480005382 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 1032480005383 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1032480005384 recombinase A; Provisional; Region: recA; PRK09354 1032480005385 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1032480005386 hexamer interface [polypeptide binding]; other site 1032480005387 Walker A motif; other site 1032480005388 ATP binding site [chemical binding]; other site 1032480005389 Walker B motif; other site 1032480005390 RecX family; Region: RecX; cl00936 1032480005391 phosphodiesterase; Provisional; Region: PRK12704 1032480005392 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1032480005393 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1032480005394 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1032480005395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480005396 dimer interface [polypeptide binding]; other site 1032480005397 conserved gate region; other site 1032480005398 putative PBP binding loops; other site 1032480005399 ABC-ATPase subunit interface; other site 1032480005400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480005401 dimer interface [polypeptide binding]; other site 1032480005402 conserved gate region; other site 1032480005403 putative PBP binding loops; other site 1032480005404 ABC-ATPase subunit interface; other site 1032480005405 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1032480005406 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1032480005407 substrate binding pocket [chemical binding]; other site 1032480005408 membrane-bound complex binding site; other site 1032480005409 hinge residues; other site 1032480005410 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1032480005411 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1032480005412 Walker A/P-loop; other site 1032480005413 ATP binding site [chemical binding]; other site 1032480005414 Q-loop/lid; other site 1032480005415 ABC transporter signature motif; other site 1032480005416 Walker B; other site 1032480005417 D-loop; other site 1032480005418 H-loop/switch region; other site 1032480005419 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 1032480005420 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1032480005421 active site 1032480005422 catalytic residues [active] 1032480005423 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1032480005424 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1032480005425 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1032480005426 FeS/SAM binding site; other site 1032480005427 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1032480005428 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480005429 NAD(P) binding site [chemical binding]; other site 1032480005430 active site 1032480005431 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1032480005432 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480005433 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1032480005434 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1032480005435 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 1032480005436 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 1032480005437 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1032480005438 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1032480005439 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1032480005440 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1032480005441 HflX GTPase family; Region: HflX; cd01878 1032480005442 G1 box; other site 1032480005443 GTP/Mg2+ binding site [chemical binding]; other site 1032480005444 Switch I region; other site 1032480005445 G2 box; other site 1032480005446 G3 box; other site 1032480005447 Switch II region; other site 1032480005448 G4 box; other site 1032480005449 G5 box; other site 1032480005450 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1032480005451 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480005452 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480005453 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1032480005454 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480005455 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1032480005456 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1032480005457 Helix-turn-helix domains; Region: HTH; cl00088 1032480005458 LexA repressor; Validated; Region: PRK00215 1032480005459 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1032480005460 Catalytic site [active] 1032480005461 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1032480005462 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1032480005463 ATP cone domain; Region: ATP-cone; pfam03477 1032480005464 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 1032480005465 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 1032480005466 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1032480005467 active site 1032480005468 dimer interface [polypeptide binding]; other site 1032480005469 effector binding site; other site 1032480005470 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1032480005471 TSCPD domain; Region: TSCPD; cl14834 1032480005472 Protease prsW family; Region: PrsW-protease; cl15823 1032480005473 Membrane transport protein; Region: Mem_trans; cl09117 1032480005474 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480005475 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480005476 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 1032480005477 putative ligand binding site [chemical binding]; other site 1032480005478 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 1032480005479 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 1032480005480 dimerization interface [polypeptide binding]; other site 1032480005481 putative active cleft [active] 1032480005482 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1032480005483 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1032480005484 ATP binding site [chemical binding]; other site 1032480005485 substrate binding site [chemical binding]; other site 1032480005486 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1032480005487 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1032480005488 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480005489 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1032480005490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480005491 dimer interface [polypeptide binding]; other site 1032480005492 conserved gate region; other site 1032480005493 putative PBP binding loops; other site 1032480005494 ABC-ATPase subunit interface; other site 1032480005495 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1032480005496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1032480005497 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1032480005498 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1032480005499 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1032480005500 active site 1032480005501 catalytic site [active] 1032480005502 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1032480005503 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1032480005504 tetramerization interface [polypeptide binding]; other site 1032480005505 NAD(P) binding site [chemical binding]; other site 1032480005506 catalytic residues [active] 1032480005507 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1032480005508 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480005509 DNA-binding site [nucleotide binding]; DNA binding site 1032480005510 FCD domain; Region: FCD; cl11656 1032480005511 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1032480005512 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1032480005513 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1032480005514 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1032480005515 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480005516 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1032480005517 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1032480005518 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1032480005519 Helix-turn-helix domains; Region: HTH; cl00088 1032480005520 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480005521 dimerization interface [polypeptide binding]; other site 1032480005522 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 1032480005523 putative phosphoketolase; Provisional; Region: PRK05261 1032480005524 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1032480005525 TPP-binding site [chemical binding]; other site 1032480005526 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 1032480005527 XFP C-terminal domain; Region: XFP_C; pfam09363 1032480005528 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1032480005529 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480005530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480005531 active site 1032480005532 phosphorylation site [posttranslational modification] 1032480005533 intermolecular recognition site; other site 1032480005534 dimerization interface [polypeptide binding]; other site 1032480005535 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480005536 DNA binding residues [nucleotide binding] 1032480005537 dimerization interface [polypeptide binding]; other site 1032480005538 GAF domain; Region: GAF_2; pfam13185 1032480005539 GAF domain; Region: GAF; cl15785 1032480005540 GAF domain; Region: GAF; cl15785 1032480005541 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1032480005542 Histidine kinase; Region: HisKA_3; pfam07730 1032480005543 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1032480005544 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1032480005545 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480005546 ATP binding site [chemical binding]; other site 1032480005547 putative Mg++ binding site [ion binding]; other site 1032480005548 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480005549 nucleotide binding region [chemical binding]; other site 1032480005550 ATP-binding site [chemical binding]; other site 1032480005551 Helicase associated domain (HA2); Region: HA2; cl04503 1032480005552 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1032480005553 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1032480005554 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1032480005555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480005556 dimer interface [polypeptide binding]; other site 1032480005557 conserved gate region; other site 1032480005558 putative PBP binding loops; other site 1032480005559 ABC-ATPase subunit interface; other site 1032480005560 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1032480005561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480005562 dimer interface [polypeptide binding]; other site 1032480005563 conserved gate region; other site 1032480005564 putative PBP binding loops; other site 1032480005565 ABC-ATPase subunit interface; other site 1032480005566 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1032480005567 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480005568 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1032480005569 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1032480005570 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1032480005571 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1032480005572 substrate binding site [chemical binding]; other site 1032480005573 ATP binding site [chemical binding]; other site 1032480005574 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1032480005575 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480005576 DNA-binding site [nucleotide binding]; DNA binding site 1032480005577 UTRA domain; Region: UTRA; cl01230 1032480005578 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480005579 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480005580 ligand binding site [chemical binding]; other site 1032480005581 dimerization interface [polypeptide binding]; other site 1032480005582 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1032480005583 substrate binding site [chemical binding]; other site 1032480005584 ATP binding site [chemical binding]; other site 1032480005585 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1032480005586 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1032480005587 putative active site [active] 1032480005588 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1032480005589 dimer interface [polypeptide binding]; other site 1032480005590 active site 1032480005591 putative oxidoreductase; Provisional; Region: PRK11579 1032480005592 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480005593 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1032480005594 FAD dependent oxidoreductase; Region: DAO; pfam01266 1032480005595 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480005596 PAC2 family; Region: PAC2; cl00847 1032480005597 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1032480005598 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1032480005599 active site 1032480005600 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1032480005601 catalytic triad [active] 1032480005602 dimer interface [polypeptide binding]; other site 1032480005603 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 1032480005604 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1032480005605 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480005606 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1032480005607 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1032480005608 DNA binding residues [nucleotide binding] 1032480005609 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1032480005610 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1032480005611 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480005612 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480005613 Ligand Binding Site [chemical binding]; other site 1032480005614 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1032480005615 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1032480005616 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480005617 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1032480005618 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1032480005619 DNA binding residues [nucleotide binding] 1032480005620 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1032480005621 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480005622 ATP binding site [chemical binding]; other site 1032480005623 Mg2+ binding site [ion binding]; other site 1032480005624 G-X-G motif; other site 1032480005625 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1032480005626 anchoring element; other site 1032480005627 dimer interface [polypeptide binding]; other site 1032480005628 ATP binding site [chemical binding]; other site 1032480005629 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1032480005630 active site 1032480005631 metal binding site [ion binding]; metal-binding site 1032480005632 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1032480005633 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1032480005634 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1032480005635 putative di-iron ligands [ion binding]; other site 1032480005636 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1032480005637 putative active site [active] 1032480005638 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1032480005639 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 1032480005640 CAP-like domain; other site 1032480005641 active site 1032480005642 primary dimer interface [polypeptide binding]; other site 1032480005643 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1032480005644 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 1032480005645 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1032480005646 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1032480005647 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1032480005648 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1032480005649 allantoate amidohydrolase; Reviewed; Region: PRK09290 1032480005650 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1032480005651 active site 1032480005652 metal binding site [ion binding]; metal-binding site 1032480005653 dimer interface [polypeptide binding]; other site 1032480005654 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1032480005655 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480005656 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480005657 catalytic residue [active] 1032480005658 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1032480005659 catalytic core [active] 1032480005660 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1032480005661 Amidase; Region: Amidase; cl11426 1032480005662 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 1032480005663 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 1032480005664 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1032480005665 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1032480005666 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480005667 DNA-binding site [nucleotide binding]; DNA binding site 1032480005668 FCD domain; Region: FCD; cl11656 1032480005669 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1032480005670 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1032480005671 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 1032480005672 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1032480005673 active site 1032480005674 homotetramer interface [polypeptide binding]; other site 1032480005675 urate oxidase; Region: urate_oxi; TIGR03383 1032480005676 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1032480005677 active site 1032480005678 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1032480005679 xanthine permease; Region: pbuX; TIGR03173 1032480005680 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 1032480005681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 1032480005682 CHAD domain; Region: CHAD; cl10506 1032480005683 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1032480005684 AMP-binding enzyme; Region: AMP-binding; cl15778 1032480005685 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480005686 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1032480005687 putative active site [active] 1032480005688 glycerol kinase; Provisional; Region: glpK; PRK00047 1032480005689 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 1032480005690 N- and C-terminal domain interface [polypeptide binding]; other site 1032480005691 active site 1032480005692 MgATP binding site [chemical binding]; other site 1032480005693 catalytic site [active] 1032480005694 metal binding site [ion binding]; metal-binding site 1032480005695 carbohydrate binding site [chemical binding]; other site 1032480005696 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1032480005697 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480005698 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480005699 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1032480005700 CoA-ligase; Region: Ligase_CoA; cl02894 1032480005701 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1032480005702 Sulfatase; Region: Sulfatase; cl10460 1032480005703 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1032480005704 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1032480005705 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1032480005706 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1032480005707 active site residue [active] 1032480005708 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1032480005709 active site residue [active] 1032480005710 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1032480005711 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1032480005712 Protein of unknown function (DUF499); Region: DUF499; pfam04465 1032480005713 Protein of unknown function DUF262; Region: DUF262; cl14890 1032480005714 Protein of unknown function DUF262; Region: DUF262; cl14890 1032480005715 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1032480005716 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 1032480005717 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 1032480005718 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480005719 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 1032480005720 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1032480005721 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480005722 non-specific DNA binding site [nucleotide binding]; other site 1032480005723 salt bridge; other site 1032480005724 sequence-specific DNA binding site [nucleotide binding]; other site 1032480005725 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1032480005726 active site 1032480005727 NTP binding site [chemical binding]; other site 1032480005728 metal binding triad [ion binding]; metal-binding site 1032480005729 antibiotic binding site [chemical binding]; other site 1032480005730 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1032480005731 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480005732 ATP binding site [chemical binding]; other site 1032480005733 putative Mg++ binding site [ion binding]; other site 1032480005734 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480005735 nucleotide binding region [chemical binding]; other site 1032480005736 ATP-binding site [chemical binding]; other site 1032480005737 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 1032480005738 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1032480005739 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 1032480005740 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1032480005741 Predicted membrane protein [Function unknown]; Region: COG2860 1032480005742 UPF0126 domain; Region: UPF0126; pfam03458 1032480005743 UPF0126 domain; Region: UPF0126; pfam03458 1032480005744 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1032480005745 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480005746 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 1032480005747 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1032480005748 metal ion-dependent adhesion site (MIDAS); other site 1032480005749 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1032480005750 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1032480005751 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1032480005752 substrate binding site; other site 1032480005753 tetramer interface; other site 1032480005754 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1032480005755 transmembrane helices; other site 1032480005756 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1032480005757 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1032480005758 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1032480005759 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1032480005760 NAD binding site [chemical binding]; other site 1032480005761 substrate binding site [chemical binding]; other site 1032480005762 homodimer interface [polypeptide binding]; other site 1032480005763 active site 1032480005764 Cupin domain; Region: Cupin_2; cl09118 1032480005765 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1032480005766 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480005767 NAD(P) binding site [chemical binding]; other site 1032480005768 active site 1032480005769 Protein of unknown function (DUF419); Region: DUF419; cl15265 1032480005770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480005771 putative substrate translocation pore; other site 1032480005772 ferrochelatase; Reviewed; Region: hemH; PRK00035 1032480005773 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1032480005774 C-terminal domain interface [polypeptide binding]; other site 1032480005775 active site 1032480005776 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1032480005777 active site 1032480005778 N-terminal domain interface [polypeptide binding]; other site 1032480005779 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1032480005780 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1032480005781 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1032480005782 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1032480005783 ssDNA binding site; other site 1032480005784 generic binding surface II; other site 1032480005785 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1032480005786 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480005787 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1032480005788 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1032480005789 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480005790 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1032480005791 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1032480005792 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480005793 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1032480005794 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1032480005795 TRAM domain; Region: TRAM; cl01282 1032480005796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 1032480005797 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 1032480005798 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1032480005799 aconitate hydratase; Validated; Region: PRK09277 1032480005800 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1032480005801 substrate binding site [chemical binding]; other site 1032480005802 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1032480005803 ligand binding site [chemical binding]; other site 1032480005804 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1032480005805 substrate binding site [chemical binding]; other site 1032480005806 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480005807 Helix-turn-helix domains; Region: HTH; cl00088 1032480005808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480005809 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1032480005810 NAD(P) binding site [chemical binding]; other site 1032480005811 active site 1032480005812 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1032480005813 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1032480005814 active site 1032480005815 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1032480005816 active site 1032480005817 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 1032480005818 MAEBL; Provisional; Region: PTZ00121 1032480005819 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480005820 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 1032480005821 Baseplate J-like protein; Region: Baseplate_J; cl01294 1032480005822 Baseplate J-like protein; Region: Baseplate_J; cl01294 1032480005823 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1032480005824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 1032480005825 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1032480005826 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1032480005827 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 1032480005828 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1032480005829 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1032480005830 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 1032480005831 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1032480005832 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1032480005833 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 1032480005834 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1032480005835 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 1032480005836 putative NAD(P) binding site [chemical binding]; other site 1032480005837 putative substrate binding site [chemical binding]; other site 1032480005838 catalytic Zn binding site [ion binding]; other site 1032480005839 structural Zn binding site [ion binding]; other site 1032480005840 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1032480005841 Helix-turn-helix domains; Region: HTH; cl00088 1032480005842 AAA domain; Region: AAA_22; pfam13401 1032480005843 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1032480005844 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480005845 DNA-binding site [nucleotide binding]; DNA binding site 1032480005846 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 1032480005847 Creatinine amidohydrolase; Region: Creatininase; cl00618 1032480005848 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1032480005849 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1032480005850 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480005851 catalytic residue [active] 1032480005852 Carboxylesterase family; Region: COesterase; pfam00135 1032480005853 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480005854 substrate binding pocket [chemical binding]; other site 1032480005855 catalytic triad [active] 1032480005856 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1032480005857 nucleotide binding site/active site [active] 1032480005858 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 1032480005859 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1032480005860 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1032480005861 TPP-binding site; other site 1032480005862 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1032480005863 PYR/PP interface [polypeptide binding]; other site 1032480005864 dimer interface [polypeptide binding]; other site 1032480005865 TPP binding site [chemical binding]; other site 1032480005866 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1032480005867 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1032480005868 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1032480005869 Vitamin K epoxide reductase family; Region: VKOR; cl01729 1032480005870 amino acid transporter; Region: 2A0306; TIGR00909 1032480005871 Spore germination protein; Region: Spore_permease; cl15802 1032480005872 Spore germination protein; Region: Spore_permease; cl15802 1032480005873 Spore germination protein; Region: Spore_permease; cl15802 1032480005874 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1032480005875 trimer interface [polypeptide binding]; other site 1032480005876 oxyanion hole (OAH) forming residues; other site 1032480005877 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1032480005878 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480005879 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1032480005880 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1032480005881 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1032480005882 dimer interface [polypeptide binding]; other site 1032480005883 active site 1032480005884 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480005885 dimerization interface [polypeptide binding]; other site 1032480005886 putative DNA binding site [nucleotide binding]; other site 1032480005887 putative Zn2+ binding site [ion binding]; other site 1032480005888 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1032480005889 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1032480005890 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1032480005891 putative active site [active] 1032480005892 catalytic site [active] 1032480005893 putative substrate binding site [chemical binding]; other site 1032480005894 HRDC domain; Region: HRDC; cl02578 1032480005895 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1032480005896 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1032480005897 substrate binding site [chemical binding]; other site 1032480005898 active site 1032480005899 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1032480005900 Chlorite dismutase; Region: Chlor_dismutase; cl01280 1032480005901 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1032480005902 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480005903 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 1032480005904 SelR domain; Region: SelR; pfam01641 1032480005905 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480005906 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1032480005907 DNA photolyase; Region: DNA_photolyase; pfam00875 1032480005908 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 1032480005909 CAAX protease self-immunity; Region: Abi; cl00558 1032480005910 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1032480005911 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1032480005912 putative NAD(P) binding site [chemical binding]; other site 1032480005913 putative active site [active] 1032480005914 TspO/MBR family; Region: TspO_MBR; cl01379 1032480005915 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1032480005916 nucleotide binding site [chemical binding]; other site 1032480005917 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1032480005918 DinB superfamily; Region: DinB_2; pfam12867 1032480005919 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1032480005920 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 1032480005921 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1032480005922 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1032480005923 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1032480005924 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1032480005925 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1032480005926 putative active site [active] 1032480005927 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1032480005928 active site 1032480005929 sulfate adenylyltransferase, large subunit; Region: CysN; TIGR02034 1032480005930 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1032480005931 CysD dimerization site [polypeptide binding]; other site 1032480005932 G1 box; other site 1032480005933 putative GEF interaction site [polypeptide binding]; other site 1032480005934 GTP/Mg2+ binding site [chemical binding]; other site 1032480005935 Switch I region; other site 1032480005936 G2 box; other site 1032480005937 G3 box; other site 1032480005938 Switch II region; other site 1032480005939 G4 box; other site 1032480005940 G5 box; other site 1032480005941 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1032480005942 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1032480005943 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1032480005944 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1032480005945 Active Sites [active] 1032480005946 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 1032480005947 ligand-binding site [chemical binding]; other site 1032480005948 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1032480005949 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1032480005950 Active Sites [active] 1032480005951 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1032480005952 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1032480005953 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1032480005954 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1032480005955 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1032480005956 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480005957 catalytic residue [active] 1032480005958 Protein of unknown function (DUF419); Region: DUF419; cl15265 1032480005959 Helix-turn-helix domains; Region: HTH; cl00088 1032480005960 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1032480005961 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480005962 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480005963 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1032480005964 Cell division protein FtsA; Region: FtsA; cl11496 1032480005965 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1032480005966 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1032480005967 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1032480005968 Probable Catalytic site; other site 1032480005969 metal-binding site 1032480005970 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1032480005971 active site 1032480005972 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1032480005973 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1032480005974 active site 1032480005975 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1032480005976 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480005977 UDP-galactopyranose mutase; Region: GLF; pfam03275 1032480005978 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1032480005979 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1032480005980 active site 1032480005981 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1032480005982 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1032480005983 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1032480005984 TPP-binding site [chemical binding]; other site 1032480005985 dimer interface [polypeptide binding]; other site 1032480005986 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1032480005987 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1032480005988 PYR/PP interface [polypeptide binding]; other site 1032480005989 dimer interface [polypeptide binding]; other site 1032480005990 TPP binding site [chemical binding]; other site 1032480005991 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1032480005992 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480005993 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1032480005994 short chain dehydrogenase; Provisional; Region: PRK06198 1032480005995 classical (c) SDRs; Region: SDR_c; cd05233 1032480005996 NAD(P) binding site [chemical binding]; other site 1032480005997 active site 1032480005998 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1032480005999 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1032480006000 Helix-turn-helix domains; Region: HTH; cl00088 1032480006001 Bacterial transcriptional regulator; Region: IclR; pfam01614 1032480006002 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1032480006003 Helix-turn-helix domains; Region: HTH; cl00088 1032480006004 Bacterial transcriptional regulator; Region: IclR; pfam01614 1032480006005 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1032480006006 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1032480006007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480006008 putative substrate translocation pore; other site 1032480006009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480006010 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480006011 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480006012 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480006013 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480006014 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1032480006015 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480006016 DNA-binding site [nucleotide binding]; DNA binding site 1032480006017 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480006018 H-loop/switch region; other site 1032480006019 Helix-turn-helix domains; Region: HTH; cl00088 1032480006020 putative transposase OrfB; Reviewed; Region: PHA02517 1032480006021 HTH-like domain; Region: HTH_21; pfam13276 1032480006022 Integrase core domain; Region: rve; cl01316 1032480006023 Integrase core domain; Region: rve_3; cl15866 1032480006024 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480006025 Walker A/P-loop; other site 1032480006026 ATP binding site [chemical binding]; other site 1032480006027 ABC transporter; Region: ABC_tran; pfam00005 1032480006028 Q-loop/lid; other site 1032480006029 ABC transporter signature motif; other site 1032480006030 Walker B; other site 1032480006031 D-loop; other site 1032480006032 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1032480006033 TM-ABC transporter signature motif; other site 1032480006034 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 1032480006035 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1032480006036 putative ligand binding site [chemical binding]; other site 1032480006037 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1032480006038 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1032480006039 PYR/PP interface [polypeptide binding]; other site 1032480006040 dimer interface [polypeptide binding]; other site 1032480006041 TPP binding site [chemical binding]; other site 1032480006042 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1032480006043 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1032480006044 TPP-binding site [chemical binding]; other site 1032480006045 KduI/IolB family; Region: KduI; cl01508 1032480006046 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 1032480006047 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1032480006048 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 1032480006049 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1032480006050 active site 1032480006051 dimer interface [polypeptide binding]; other site 1032480006052 motif 1; other site 1032480006053 motif 2; other site 1032480006054 motif 3; other site 1032480006055 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1032480006056 anticodon binding site; other site 1032480006057 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1032480006058 nucleotide binding site/active site [active] 1032480006059 HIT family signature motif; other site 1032480006060 catalytic residue [active] 1032480006061 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1032480006062 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1032480006063 putative acyl-acceptor binding pocket; other site 1032480006064 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1032480006065 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1032480006066 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1032480006067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1032480006068 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1032480006069 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 1032480006070 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1032480006071 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1032480006072 lipoyl attachment site [posttranslational modification]; other site 1032480006073 Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]; Region: SUA7; COG1405 1032480006074 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1032480006075 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1032480006076 phosphopeptide binding site; other site 1032480006077 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1032480006078 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1032480006079 DNA binding residues [nucleotide binding] 1032480006080 Bifunctional nuclease; Region: DNase-RNase; cl00553 1032480006081 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1032480006082 DNA binding residues [nucleotide binding] 1032480006083 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1032480006084 putative dimer interface [polypeptide binding]; other site 1032480006085 glycine dehydrogenase; Provisional; Region: PRK05367 1032480006086 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1032480006087 tetramer interface [polypeptide binding]; other site 1032480006088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480006089 catalytic residue [active] 1032480006090 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1032480006091 tetramer interface [polypeptide binding]; other site 1032480006092 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480006093 catalytic residue [active] 1032480006094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480006095 maltose O-acetyltransferase; Provisional; Region: PRK10092 1032480006096 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1032480006097 active site 1032480006098 substrate binding site [chemical binding]; other site 1032480006099 trimer interface [polypeptide binding]; other site 1032480006100 CoA binding site [chemical binding]; other site 1032480006101 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1032480006102 EamA-like transporter family; Region: EamA; cl01037 1032480006103 ANTAR domain; Region: ANTAR; cl04297 1032480006104 GAF domain; Region: GAF; cl15785 1032480006105 ANTAR domain; Region: ANTAR; cl04297 1032480006106 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1032480006107 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480006108 DNA-binding site [nucleotide binding]; DNA binding site 1032480006109 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1032480006110 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1032480006111 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1032480006112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480006113 ATP binding site [chemical binding]; other site 1032480006114 Mg2+ binding site [ion binding]; other site 1032480006115 G-X-G motif; other site 1032480006116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480006117 active site 1032480006118 phosphorylation site [posttranslational modification] 1032480006119 intermolecular recognition site; other site 1032480006120 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480006121 DNA binding residues [nucleotide binding] 1032480006122 dimerization interface [polypeptide binding]; other site 1032480006123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480006124 putative substrate translocation pore; other site 1032480006125 Amidinotransferase; Region: Amidinotransf; cl12043 1032480006126 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1032480006127 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1032480006128 Helix-turn-helix domains; Region: HTH; cl00088 1032480006129 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1032480006130 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1032480006131 tetrameric interface [polypeptide binding]; other site 1032480006132 NAD binding site [chemical binding]; other site 1032480006133 catalytic residues [active] 1032480006134 hypothetical protein; Provisional; Region: PRK06062 1032480006135 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1032480006136 inhibitor-cofactor binding pocket; inhibition site 1032480006137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480006138 catalytic residue [active] 1032480006139 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1032480006140 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480006141 DNA-binding site [nucleotide binding]; DNA binding site 1032480006142 FCD domain; Region: FCD; cl11656 1032480006143 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1032480006144 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1032480006145 NAD(P) binding site [chemical binding]; other site 1032480006146 catalytic residues [active] 1032480006147 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1032480006148 Proline racemase; Region: Pro_racemase; pfam05544 1032480006149 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1032480006150 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1032480006151 inhibitor site; inhibition site 1032480006152 active site 1032480006153 dimer interface [polypeptide binding]; other site 1032480006154 catalytic residue [active] 1032480006155 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1032480006156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480006157 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1032480006158 Proline racemase; Region: Pro_racemase; pfam05544 1032480006159 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1032480006160 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1032480006161 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1032480006162 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1032480006163 tetrameric interface [polypeptide binding]; other site 1032480006164 NAD binding site [chemical binding]; other site 1032480006165 catalytic residues [active] 1032480006166 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 1032480006167 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 1032480006168 FAD dependent oxidoreductase; Region: DAO; pfam01266 1032480006169 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480006170 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1032480006171 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1032480006172 Helix-turn-helix domains; Region: HTH; cl00088 1032480006173 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1032480006174 putative dimerization interface [polypeptide binding]; other site 1032480006175 TOBE domain; Region: TOBE_2; cl01440 1032480006176 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1032480006177 DNA binding residues [nucleotide binding] 1032480006178 TOBE domain; Region: TOBE_2; cl01440 1032480006179 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1032480006180 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480006181 Walker A/P-loop; other site 1032480006182 ATP binding site [chemical binding]; other site 1032480006183 Q-loop/lid; other site 1032480006184 ABC transporter signature motif; other site 1032480006185 Walker B; other site 1032480006186 D-loop; other site 1032480006187 H-loop/switch region; other site 1032480006188 TOBE domain; Region: TOBE_2; cl01440 1032480006189 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1032480006190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480006191 putative PBP binding loops; other site 1032480006192 ABC-ATPase subunit interface; other site 1032480006193 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1032480006194 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480006195 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480006196 Ligand Binding Site [chemical binding]; other site 1032480006197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480006198 putative substrate translocation pore; other site 1032480006199 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1032480006200 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1032480006201 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1032480006202 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1032480006203 Ligand Binding Site [chemical binding]; other site 1032480006204 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1032480006205 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1032480006206 Ligand binding site [chemical binding]; other site 1032480006207 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1032480006208 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1032480006209 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 1032480006210 putative active site [active] 1032480006211 putative FMN binding site [chemical binding]; other site 1032480006212 putative catalytic residue [active] 1032480006213 putative substrate binding site [chemical binding]; other site 1032480006214 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480006215 NAD(P) binding site [chemical binding]; other site 1032480006216 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480006217 DNA-binding site [nucleotide binding]; DNA binding site 1032480006218 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1032480006219 Helix-turn-helix domains; Region: HTH; cl00088 1032480006220 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1032480006221 dimerization interface [polypeptide binding]; other site 1032480006222 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1032480006223 classical (c) SDRs; Region: SDR_c; cd05233 1032480006224 NAD(P) binding site [chemical binding]; other site 1032480006225 active site 1032480006226 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1032480006227 classical (c) SDRs; Region: SDR_c; cd05233 1032480006228 NAD(P) binding site [chemical binding]; other site 1032480006229 active site 1032480006230 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 1032480006231 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480006232 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1032480006233 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1032480006234 inhibitor site; inhibition site 1032480006235 active site 1032480006236 dimer interface [polypeptide binding]; other site 1032480006237 catalytic residue [active] 1032480006238 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1032480006239 Proline racemase; Region: Pro_racemase; pfam05544 1032480006240 FAD dependent oxidoreductase; Region: DAO; pfam01266 1032480006241 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1032480006242 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 1032480006243 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1032480006244 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1032480006245 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480006246 DNA-binding site [nucleotide binding]; DNA binding site 1032480006247 FCD domain; Region: FCD; cl11656 1032480006248 short chain dehydrogenase; Provisional; Region: PRK06197 1032480006249 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1032480006250 putative NAD(P) binding site [chemical binding]; other site 1032480006251 active site 1032480006252 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1032480006253 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1032480006254 THF binding site; other site 1032480006255 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1032480006256 substrate binding site [chemical binding]; other site 1032480006257 THF binding site; other site 1032480006258 zinc-binding site [ion binding]; other site 1032480006259 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1032480006260 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1032480006261 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1032480006262 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1032480006263 Walker A/P-loop; other site 1032480006264 ATP binding site [chemical binding]; other site 1032480006265 Q-loop/lid; other site 1032480006266 ABC transporter signature motif; other site 1032480006267 Walker B; other site 1032480006268 D-loop; other site 1032480006269 H-loop/switch region; other site 1032480006270 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1032480006271 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1032480006272 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1032480006273 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1032480006274 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480006275 active site 1032480006276 phosphorylation site [posttranslational modification] 1032480006277 intermolecular recognition site; other site 1032480006278 dimerization interface [polypeptide binding]; other site 1032480006279 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1032480006280 DNA binding site [nucleotide binding] 1032480006281 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1032480006282 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1032480006283 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1032480006284 dimer interface [polypeptide binding]; other site 1032480006285 phosphorylation site [posttranslational modification] 1032480006286 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480006287 ATP binding site [chemical binding]; other site 1032480006288 Mg2+ binding site [ion binding]; other site 1032480006289 G-X-G motif; other site 1032480006290 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1032480006291 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480006292 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1032480006293 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480006294 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1032480006295 DNA binding residues [nucleotide binding] 1032480006296 Family description; Region: VCBS; pfam13517 1032480006297 FG-GAP repeat; Region: FG-GAP; cl15299 1032480006298 FG-GAP repeat; Region: FG-GAP; cl15299 1032480006299 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1032480006300 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480006301 active site 1032480006302 catalytic tetrad [active] 1032480006303 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1032480006304 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1032480006305 NAD(P) binding site [chemical binding]; other site 1032480006306 catalytic residues [active] 1032480006307 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 1032480006308 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1032480006309 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1032480006310 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1032480006311 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 1032480006312 Walker A/P-loop; other site 1032480006313 ATP binding site [chemical binding]; other site 1032480006314 Q-loop/lid; other site 1032480006315 ABC transporter signature motif; other site 1032480006316 Walker B; other site 1032480006317 D-loop; other site 1032480006318 H-loop/switch region; other site 1032480006319 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 1032480006320 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1032480006321 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 1032480006322 Walker A/P-loop; other site 1032480006323 ATP binding site [chemical binding]; other site 1032480006324 Q-loop/lid; other site 1032480006325 ABC transporter signature motif; other site 1032480006326 Walker B; other site 1032480006327 D-loop; other site 1032480006328 H-loop/switch region; other site 1032480006329 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1032480006330 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1032480006331 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1032480006332 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1032480006333 Helix-turn-helix domains; Region: HTH; cl00088 1032480006334 Peptidase family M48; Region: Peptidase_M48; cl12018 1032480006335 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1032480006336 catalytic residues [active] 1032480006337 dimer interface [polypeptide binding]; other site 1032480006338 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1032480006339 intersubunit interface [polypeptide binding]; other site 1032480006340 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1032480006341 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1032480006342 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1032480006343 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1032480006344 Fibronectin type III-like domain; Region: Fn3-like; cl15273 1032480006345 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1032480006346 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1032480006347 Sulfate transporter family; Region: Sulfate_transp; cl15842 1032480006348 high affinity sulphate transporter 1; Region: sulP; TIGR00815 1032480006349 Sulfate transporter family; Region: Sulfate_transp; cl15842 1032480006350 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1032480006351 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1032480006352 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1032480006353 metal binding site [ion binding]; metal-binding site 1032480006354 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1032480006355 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 1032480006356 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1032480006357 ABC-ATPase subunit interface; other site 1032480006358 dimer interface [polypeptide binding]; other site 1032480006359 putative PBP binding regions; other site 1032480006360 Helix-turn-helix domains; Region: HTH; cl00088 1032480006361 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1032480006362 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1032480006363 FeoA domain; Region: FeoA; cl00838 1032480006364 Beta propeller domain; Region: Beta_propel; pfam09826 1032480006365 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1032480006366 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480006367 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1032480006368 DNA binding residues [nucleotide binding] 1032480006369 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480006370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480006371 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1032480006372 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1032480006373 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1032480006374 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1032480006375 substrate binding site [chemical binding]; other site 1032480006376 ATP binding site [chemical binding]; other site 1032480006377 Entner-Doudoroff aldolase; Region: eda; TIGR01182 1032480006378 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1032480006379 active site 1032480006380 intersubunit interface [polypeptide binding]; other site 1032480006381 catalytic residue [active] 1032480006382 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1032480006383 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1032480006384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480006385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480006386 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480006387 Helix-turn-helix domains; Region: HTH; cl00088 1032480006388 Survival protein SurE; Region: SurE; cl00448 1032480006389 Predicted ATPase [General function prediction only]; Region: COG3899 1032480006390 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480006391 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480006392 DNA binding residues [nucleotide binding] 1032480006393 dimerization interface [polypeptide binding]; other site 1032480006394 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480006395 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1032480006396 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1032480006397 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1032480006398 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1032480006399 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1032480006400 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1032480006401 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1032480006402 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1032480006403 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1032480006404 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480006405 non-specific DNA binding site [nucleotide binding]; other site 1032480006406 salt bridge; other site 1032480006407 sequence-specific DNA binding site [nucleotide binding]; other site 1032480006408 2-dehydropantoate 2-reductase; Provisional; Region: PRK08229 1032480006409 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480006410 Helix-turn-helix domains; Region: HTH; cl00088 1032480006411 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480006412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480006413 putative substrate translocation pore; other site 1032480006414 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1032480006415 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480006416 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 1032480006417 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1032480006418 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1032480006419 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1032480006420 nudix motif; other site 1032480006421 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1032480006422 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480006423 DNA-binding site [nucleotide binding]; DNA binding site 1032480006424 Helix-turn-helix domains; Region: HTH; cl00088 1032480006425 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1032480006426 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480006427 hypothetical protein; Provisional; Region: PRK07588 1032480006428 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480006429 hypothetical protein; Provisional; Region: PRK08317 1032480006430 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480006431 S-adenosylmethionine binding site [chemical binding]; other site 1032480006432 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1032480006433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480006434 intermolecular recognition site; other site 1032480006435 active site 1032480006436 dimerization interface [polypeptide binding]; other site 1032480006437 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1032480006438 DNA binding site [nucleotide binding] 1032480006439 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1032480006440 dimer interface [polypeptide binding]; other site 1032480006441 phosphorylation site [posttranslational modification] 1032480006442 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1032480006443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480006444 ATP binding site [chemical binding]; other site 1032480006445 Mg2+ binding site [ion binding]; other site 1032480006446 G-X-G motif; other site 1032480006447 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1032480006448 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480006449 NAD(P) binding site [chemical binding]; other site 1032480006450 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480006451 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1032480006452 homotetrameric interface [polypeptide binding]; other site 1032480006453 putative active site [active] 1032480006454 metal binding site [ion binding]; metal-binding site 1032480006455 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1032480006456 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 1032480006457 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1032480006458 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 1032480006459 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480006460 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480006461 active site 1032480006462 catalytic tetrad [active] 1032480006463 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1032480006464 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480006465 Predicted ATPase [General function prediction only]; Region: COG3899 1032480006466 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 1032480006467 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480006468 DNA binding residues [nucleotide binding] 1032480006469 dimerization interface [polypeptide binding]; other site 1032480006470 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1032480006471 Predicted membrane protein [Function unknown]; Region: COG2364 1032480006472 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1032480006473 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480006474 DNA-binding site [nucleotide binding]; DNA binding site 1032480006475 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480006476 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480006477 homodimer interface [polypeptide binding]; other site 1032480006478 catalytic residue [active] 1032480006479 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1032480006480 FOG: CBS domain [General function prediction only]; Region: COG0517 1032480006481 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1032480006482 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480006483 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 1032480006484 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1032480006485 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1032480006486 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480006487 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1032480006488 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1032480006489 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480006490 non-specific DNA binding site [nucleotide binding]; other site 1032480006491 salt bridge; other site 1032480006492 sequence-specific DNA binding site [nucleotide binding]; other site 1032480006493 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1032480006494 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a...; Region: EPT_RTPC-like; cl00288 1032480006495 putative active site [active] 1032480006496 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1032480006497 RHS Repeat; Region: RHS_repeat; cl11982 1032480006498 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1032480006499 pyridoxamine kinase; Validated; Region: PRK05756 1032480006500 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1032480006501 dimer interface [polypeptide binding]; other site 1032480006502 pyridoxal binding site [chemical binding]; other site 1032480006503 ATP binding site [chemical binding]; other site 1032480006504 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1032480006505 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1032480006506 putative active site [active] 1032480006507 catalytic site [active] 1032480006508 putative metal binding site [ion binding]; other site 1032480006509 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1032480006510 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1032480006511 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 1032480006512 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1032480006513 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1032480006514 Ligand binding site; other site 1032480006515 Putative Catalytic site; other site 1032480006516 DXD motif; other site 1032480006517 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1032480006518 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1032480006519 putative active site [active] 1032480006520 catalytic triad [active] 1032480006521 putative dimer interface [polypeptide binding]; other site 1032480006522 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 1032480006523 nudix motif; other site 1032480006524 Helix-turn-helix domains; Region: HTH; cl00088 1032480006525 Winged helix-turn helix; Region: HTH_29; pfam13551 1032480006526 Helix-turn-helix domains; Region: HTH; cl00088 1032480006527 Integrase core domain; Region: rve; cl01316 1032480006528 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1032480006529 putative transposase OrfB; Reviewed; Region: PHA02517 1032480006530 HTH-like domain; Region: HTH_21; pfam13276 1032480006531 Integrase core domain; Region: rve; cl01316 1032480006532 Integrase core domain; Region: rve_3; cl15866 1032480006533 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 1032480006534 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1032480006535 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1032480006536 active site 1032480006537 Helix-turn-helix domains; Region: HTH; cl00088 1032480006538 5'-3' exonuclease; Region: 53EXOc; smart00475 1032480006539 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1032480006540 active site 1032480006541 metal binding site 1 [ion binding]; metal-binding site 1032480006542 putative 5' ssDNA interaction site; other site 1032480006543 metal binding site 3; metal-binding site 1032480006544 metal binding site 2 [ion binding]; metal-binding site 1032480006545 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1032480006546 putative DNA binding site [nucleotide binding]; other site 1032480006547 putative metal binding site [ion binding]; other site 1032480006548 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1032480006549 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1032480006550 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 1032480006551 homodimer interface [polypeptide binding]; other site 1032480006552 substrate-cofactor binding pocket; other site 1032480006553 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480006554 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1032480006555 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1032480006556 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1032480006557 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1032480006558 active site 1032480006559 homodimer interface [polypeptide binding]; other site 1032480006560 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1032480006561 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; cl15759 1032480006562 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1032480006563 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1032480006564 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480006565 S-adenosylmethionine binding site [chemical binding]; other site 1032480006566 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1032480006567 OpgC protein; Region: OpgC_C; cl00792 1032480006568 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1032480006569 Ligand binding site; other site 1032480006570 Putative Catalytic site; other site 1032480006571 DXD motif; other site 1032480006572 GtrA-like protein; Region: GtrA; cl00971 1032480006573 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1032480006574 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1032480006575 inhibitor-cofactor binding pocket; inhibition site 1032480006576 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480006577 catalytic residue [active] 1032480006578 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480006579 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480006580 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1032480006581 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1032480006582 active site 1032480006583 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1032480006584 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480006585 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1032480006586 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480006587 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1032480006588 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 1032480006589 putative trimer interface [polypeptide binding]; other site 1032480006590 putative active site [active] 1032480006591 putative substrate binding site [chemical binding]; other site 1032480006592 putative CoA binding site [chemical binding]; other site 1032480006593 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1032480006594 active site 1032480006595 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1032480006596 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480006597 Protein of unknown function (DUF563); Region: DUF563; cl15705 1032480006598 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1032480006599 substrate binding site; other site 1032480006600 dimer interface; other site 1032480006601 short chain dehydrogenase; Provisional; Region: PRK06198 1032480006602 classical (c) SDRs; Region: SDR_c; cd05233 1032480006603 NAD(P) binding site [chemical binding]; other site 1032480006604 active site 1032480006605 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1032480006606 putative catalytic site [active] 1032480006607 putative metal binding site [ion binding]; other site 1032480006608 putative phosphate binding site [ion binding]; other site 1032480006609 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1032480006610 putative catalytic site [active] 1032480006611 putative metal binding site [ion binding]; other site 1032480006612 putative phosphate binding site [ion binding]; other site 1032480006613 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1032480006614 putative catalytic site [active] 1032480006615 putative metal binding site [ion binding]; other site 1032480006616 putative phosphate binding site [ion binding]; other site 1032480006617 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 1032480006618 diiron binding motif [ion binding]; other site 1032480006619 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 1032480006620 Sulfotransferase family; Region: Sulfotransfer_3; cl14559 1032480006621 Sulfate transporter family; Region: Sulfate_transp; cl15842 1032480006622 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1032480006623 Sulfate transporter family; Region: Sulfate_transp; cl15842 1032480006624 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1032480006625 Helix-turn-helix domains; Region: HTH; cl00088 1032480006626 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480006627 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480006628 active site 1032480006629 catalytic tetrad [active] 1032480006630 Carboxylesterase family; Region: COesterase; pfam00135 1032480006631 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480006632 substrate binding pocket [chemical binding]; other site 1032480006633 catalytic triad [active] 1032480006634 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1032480006635 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1032480006636 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1032480006637 Helix-turn-helix domains; Region: HTH; cl00088 1032480006638 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1032480006639 Helix-turn-helix domains; Region: HTH; cl00088 1032480006640 metabolite-proton symporter; Region: 2A0106; TIGR00883 1032480006641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480006642 putative substrate translocation pore; other site 1032480006643 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480006644 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1032480006645 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480006646 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 1032480006647 GTP-binding protein Der; Reviewed; Region: PRK03003 1032480006648 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1032480006649 G1 box; other site 1032480006650 GTP/Mg2+ binding site [chemical binding]; other site 1032480006651 Switch I region; other site 1032480006652 G2 box; other site 1032480006653 Switch II region; other site 1032480006654 G3 box; other site 1032480006655 G4 box; other site 1032480006656 G5 box; other site 1032480006657 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1032480006658 G1 box; other site 1032480006659 GTP/Mg2+ binding site [chemical binding]; other site 1032480006660 Switch I region; other site 1032480006661 G2 box; other site 1032480006662 G3 box; other site 1032480006663 Switch II region; other site 1032480006664 G4 box; other site 1032480006665 G5 box; other site 1032480006666 cytidylate kinase; Provisional; Region: cmk; PRK00023 1032480006667 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1032480006668 CMP-binding site; other site 1032480006669 The sites determining sugar specificity; other site 1032480006670 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 1032480006671 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480006672 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1032480006673 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1032480006674 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1032480006675 active site 1032480006676 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1032480006677 active site 1032480006678 Pup-like protein; Region: Pup; cl05289 1032480006679 Pup-ligase protein; Region: Pup_ligase; cl15463 1032480006680 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1032480006681 proteasome ATPase; Region: pup_AAA; TIGR03689 1032480006682 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480006683 Walker A motif; other site 1032480006684 ATP binding site [chemical binding]; other site 1032480006685 Walker B motif; other site 1032480006686 arginine finger; other site 1032480006687 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1032480006688 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480006689 S-adenosylmethionine binding site [chemical binding]; other site 1032480006690 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1032480006691 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1032480006692 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1032480006693 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1032480006694 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480006695 motif II; other site 1032480006696 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1032480006697 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1032480006698 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1032480006699 substrate binding pocket [chemical binding]; other site 1032480006700 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1032480006701 B12 binding site [chemical binding]; other site 1032480006702 cobalt ligand [ion binding]; other site 1032480006703 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1032480006704 PAC2 family; Region: PAC2; cl00847 1032480006705 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1032480006706 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1032480006707 substrate binding site [chemical binding]; other site 1032480006708 hexamer interface [polypeptide binding]; other site 1032480006709 metal binding site [ion binding]; metal-binding site 1032480006710 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1032480006711 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 1032480006712 metal binding site [ion binding]; metal-binding site 1032480006713 putative dimer interface [polypeptide binding]; other site 1032480006714 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1032480006715 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 1032480006716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 1032480006717 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1032480006718 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1032480006719 putative active site [active] 1032480006720 substrate binding site [chemical binding]; other site 1032480006721 putative cosubstrate binding site; other site 1032480006722 catalytic site [active] 1032480006723 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1032480006724 substrate binding site [chemical binding]; other site 1032480006725 primosome assembly protein PriA; Provisional; Region: PRK14873 1032480006726 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 1032480006727 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1032480006728 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 1032480006729 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1032480006730 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1032480006731 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1032480006732 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1032480006733 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1032480006734 Flavoprotein; Region: Flavoprotein; cl08021 1032480006735 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 1032480006736 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 1032480006737 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1032480006738 catalytic site [active] 1032480006739 G-X2-G-X-G-K; other site 1032480006740 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 1032480006741 active site 1032480006742 dimer interface [polypeptide binding]; other site 1032480006743 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1032480006744 quinone interaction residues [chemical binding]; other site 1032480006745 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 1032480006746 active site 1032480006747 catalytic residues [active] 1032480006748 FMN binding site [chemical binding]; other site 1032480006749 substrate binding site [chemical binding]; other site 1032480006750 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1032480006751 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1032480006752 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1032480006753 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1032480006754 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1032480006755 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1032480006756 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1032480006757 IMP binding site; other site 1032480006758 dimer interface [polypeptide binding]; other site 1032480006759 interdomain contacts; other site 1032480006760 partial ornithine binding site; other site 1032480006761 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1032480006762 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 1032480006763 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1032480006764 catalytic site [active] 1032480006765 subunit interface [polypeptide binding]; other site 1032480006766 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480006767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480006768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480006769 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1032480006770 putative RNA binding site [nucleotide binding]; other site 1032480006771 elongation factor P; Validated; Region: PRK00529 1032480006772 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1032480006773 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1032480006774 RNA binding site [nucleotide binding]; other site 1032480006775 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1032480006776 RNA binding site [nucleotide binding]; other site 1032480006777 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1032480006778 active site 1032480006779 dimer interface [polypeptide binding]; other site 1032480006780 metal binding site [ion binding]; metal-binding site 1032480006781 shikimate kinase; Reviewed; Region: aroK; PRK00131 1032480006782 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1032480006783 ADP binding site [chemical binding]; other site 1032480006784 magnesium binding site [ion binding]; other site 1032480006785 putative shikimate binding site; other site 1032480006786 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cl00323 1032480006787 Tetramer interface [polypeptide binding]; other site 1032480006788 active site 1032480006789 FMN-binding site [chemical binding]; other site 1032480006790 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1032480006791 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1032480006792 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1032480006793 shikimate binding site; other site 1032480006794 NAD(P) binding site [chemical binding]; other site 1032480006795 YceG-like family; Region: YceG; pfam02618 1032480006796 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1032480006797 dimerization interface [polypeptide binding]; other site 1032480006798 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 1032480006799 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1032480006800 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 1032480006801 motif 1; other site 1032480006802 active site 1032480006803 motif 2; other site 1032480006804 motif 3; other site 1032480006805 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 1032480006806 recombination factor protein RarA; Reviewed; Region: PRK13342 1032480006807 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480006808 Walker A motif; other site 1032480006809 ATP binding site [chemical binding]; other site 1032480006810 Walker B motif; other site 1032480006811 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1032480006812 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 1032480006813 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1032480006814 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1032480006815 dimer interface [polypeptide binding]; other site 1032480006816 anticodon binding site; other site 1032480006817 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 1032480006818 homodimer interface [polypeptide binding]; other site 1032480006819 motif 1; other site 1032480006820 active site 1032480006821 motif 2; other site 1032480006822 GAD domain; Region: GAD; pfam02938 1032480006823 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 1032480006824 active site 1032480006825 motif 3; other site 1032480006826 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 1032480006827 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1032480006828 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 1032480006829 dimer interface [polypeptide binding]; other site 1032480006830 motif 1; other site 1032480006831 active site 1032480006832 motif 2; other site 1032480006833 motif 3; other site 1032480006834 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1032480006835 anticodon binding site; other site 1032480006836 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 1032480006837 putative active site [active] 1032480006838 putative NTP binding site [chemical binding]; other site 1032480006839 putative nucleic acid binding site [nucleotide binding]; other site 1032480006840 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1032480006841 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 1032480006842 catalytic site [active] 1032480006843 metal binding site [ion binding]; metal-binding site 1032480006844 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1032480006845 DNA-binding site [nucleotide binding]; DNA binding site 1032480006846 RNA-binding motif; other site 1032480006847 aspartate aminotransferase; Provisional; Region: PRK06836 1032480006848 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 1032480006849 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1032480006850 B12 binding site [chemical binding]; other site 1032480006851 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1032480006852 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 1032480006853 predicted active site [active] 1032480006854 catalytic triad [active] 1032480006855 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1032480006856 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480006857 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1032480006858 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1032480006859 active site 1032480006860 multimer interface [polypeptide binding]; other site 1032480006861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1032480006862 Helix-turn-helix domains; Region: HTH; cl00088 1032480006863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480006864 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1032480006865 classical (c) SDRs; Region: SDR_c; cd05233 1032480006866 NAD(P) binding site [chemical binding]; other site 1032480006867 active site 1032480006868 glycogen branching enzyme; Provisional; Region: PRK14705 1032480006869 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1032480006870 CoenzymeA binding site [chemical binding]; other site 1032480006871 subunit interaction site [polypeptide binding]; other site 1032480006872 PHB binding site; other site 1032480006873 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1032480006874 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1032480006875 Walker A/P-loop; other site 1032480006876 ATP binding site [chemical binding]; other site 1032480006877 Q-loop/lid; other site 1032480006878 ABC transporter signature motif; other site 1032480006879 Walker B; other site 1032480006880 D-loop; other site 1032480006881 H-loop/switch region; other site 1032480006882 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1032480006883 Walker A/P-loop; other site 1032480006884 ATP binding site [chemical binding]; other site 1032480006885 Q-loop/lid; other site 1032480006886 ABC transporter signature motif; other site 1032480006887 Walker B; other site 1032480006888 D-loop; other site 1032480006889 H-loop/switch region; other site 1032480006890 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1032480006891 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1032480006892 Sulfatase; Region: Sulfatase; cl10460 1032480006893 Sulfatase; Region: Sulfatase; cl10460 1032480006894 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480006895 dimer interface [polypeptide binding]; other site 1032480006896 conserved gate region; other site 1032480006897 putative PBP binding loops; other site 1032480006898 ABC-ATPase subunit interface; other site 1032480006899 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1032480006900 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1032480006901 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1032480006902 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1032480006903 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1032480006904 Predicted ATPase [General function prediction only]; Region: COG3899 1032480006905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480006906 Walker A motif; other site 1032480006907 ATP binding site [chemical binding]; other site 1032480006908 Walker B motif; other site 1032480006909 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480006910 DNA binding residues [nucleotide binding] 1032480006911 dimerization interface [polypeptide binding]; other site 1032480006912 EamA-like transporter family; Region: EamA; cl01037 1032480006913 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480006914 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1032480006915 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1032480006916 active site 1032480006917 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1032480006918 Membrane transport protein; Region: Mem_trans; cl09117 1032480006919 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1032480006920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480006921 S-adenosylmethionine binding site [chemical binding]; other site 1032480006922 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480006923 dimerization interface [polypeptide binding]; other site 1032480006924 putative DNA binding site [nucleotide binding]; other site 1032480006925 putative Zn2+ binding site [ion binding]; other site 1032480006926 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480006927 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 1032480006928 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1032480006929 Spore germination protein; Region: Spore_permease; cl15802 1032480006930 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1032480006931 homotrimer interaction site [polypeptide binding]; other site 1032480006932 putative active site [active] 1032480006933 Protein of unknown function (DUF1237); Region: DUF1237; cl15402 1032480006934 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 1032480006935 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1032480006936 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480006937 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480006938 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1032480006939 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480006940 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1032480006941 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1032480006942 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1032480006943 putative active site; other site 1032480006944 catalytic residue [active] 1032480006945 Predicted alternative 3-dehydroquinate synthase [Amino acid transport and metabolism]; Region: COG1465 1032480006946 3-dehydroquinate synthase (EC 4.6.1.3); Region: DHQS; cl00640 1032480006947 D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734 1032480006948 AMP-binding enzyme; Region: AMP-binding; cl15778 1032480006949 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1032480006950 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1032480006951 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 1032480006952 nucleophilic elbow; other site 1032480006953 catalytic triad; other site 1032480006954 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480006955 potential frameshift: common BLAST hit: gi|255531923|ref|YP_003092295.1| polysaccharide deacetylase 1032480006956 poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938 1032480006957 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1032480006958 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1032480006959 putative active site [active] 1032480006960 putative metal binding site [ion binding]; other site 1032480006961 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 1032480006962 Core-2/I-Branching enzyme; Region: Branch; pfam02485 1032480006963 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1032480006964 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1032480006965 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1032480006966 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1032480006967 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1032480006968 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480006969 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1032480006970 active site 1032480006971 catalytic residues [active] 1032480006972 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480006973 dimerization interface [polypeptide binding]; other site 1032480006974 putative DNA binding site [nucleotide binding]; other site 1032480006975 putative Zn2+ binding site [ion binding]; other site 1032480006976 Cation efflux family; Region: Cation_efflux; cl00316 1032480006977 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480006978 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480006979 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1032480006980 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480006981 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1032480006982 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480006983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480006984 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1032480006985 potential frameshift: common BLAST hit: gi|134101071|ref|YP_001106732.1| sugar phosphate isomerase/epimerase 1032480006986 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1032480006987 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1032480006988 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1032480006989 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1032480006990 active site 1032480006991 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1032480006992 putative glycosyl transferase; Provisional; Region: PRK10073 1032480006993 active site 1032480006994 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1032480006995 active site 1032480006996 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1032480006997 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1032480006998 active site 1032480006999 potential frameshift: common BLAST hit: gi|312194019|ref|YP_004014080.1| glycosyl transferase 2 1032480007000 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 1032480007001 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1032480007002 Ligand binding site; other site 1032480007003 Putative Catalytic site; other site 1032480007004 DXD motif; other site 1032480007005 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 1032480007006 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1032480007007 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1032480007008 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480007009 DNA-binding site [nucleotide binding]; DNA binding site 1032480007010 FCD domain; Region: FCD; cl11656 1032480007011 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1032480007012 ABC-ATPase subunit interface; other site 1032480007013 dimer interface [polypeptide binding]; other site 1032480007014 putative PBP binding regions; other site 1032480007015 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1032480007016 ABC-ATPase subunit interface; other site 1032480007017 dimer interface [polypeptide binding]; other site 1032480007018 putative PBP binding regions; other site 1032480007019 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1032480007020 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1032480007021 siderophore binding site; other site 1032480007022 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480007023 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1032480007024 NAD(P) binding site [chemical binding]; other site 1032480007025 active site 1032480007026 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1032480007027 2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275 1032480007028 AMP-binding enzyme; Region: AMP-binding; cl15778 1032480007029 AMP-binding enzyme; Region: AMP-binding; cl15778 1032480007030 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1032480007031 Isochorismatase family; Region: Isochorismatase; pfam00857 1032480007032 catalytic triad [active] 1032480007033 conserved cis-peptide bond; other site 1032480007034 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1032480007035 AMP-binding enzyme; Region: AMP-binding; cl15778 1032480007036 AMP-binding enzyme; Region: AMP-binding; cl15778 1032480007037 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1032480007038 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1032480007039 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1032480007040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480007041 putative substrate translocation pore; other site 1032480007042 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1032480007043 potential frameshift: common BLAST hit: gi|284029502|ref|YP_003379433.1| Bcr/CflA subfamily drug resistance transporter 1032480007044 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1032480007045 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1032480007046 Vitamin K epoxide reductase family; Region: VKOR; cl01729 1032480007047 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480007048 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1032480007049 PLD-like domain; Region: PLDc_2; pfam13091 1032480007050 putative active site [active] 1032480007051 catalytic site [active] 1032480007052 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1032480007053 putative active site [active] 1032480007054 catalytic site [active] 1032480007055 Transglycosylase; Region: Transgly; cl07896 1032480007056 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1032480007057 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1032480007058 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480007059 Helix-turn-helix domains; Region: HTH; cl00088 1032480007060 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 1032480007061 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1032480007062 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1032480007063 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1032480007064 Fibronectin type III-like domain; Region: Fn3-like; cl15273 1032480007065 Cupin domain; Region: Cupin_2; cl09118 1032480007066 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480007067 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1032480007068 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480007069 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1032480007070 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 1032480007071 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1032480007072 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 1032480007073 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1032480007074 metabolite-proton symporter; Region: 2A0106; TIGR00883 1032480007075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480007076 putative substrate translocation pore; other site 1032480007077 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1032480007078 FAD binding domain; Region: FAD_binding_4; pfam01565 1032480007079 GAF domain; Region: GAF; cl15785 1032480007080 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480007081 DNA binding residues [nucleotide binding] 1032480007082 dimerization interface [polypeptide binding]; other site 1032480007083 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1032480007084 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1032480007085 active site 1032480007086 catalytic triad [active] 1032480007087 oxyanion hole [active] 1032480007088 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1032480007089 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480007090 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480007091 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1032480007092 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1032480007093 flagellar biosynthesis chaperone; Validated; Region: fliJ; cl09161 1032480007094 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1032480007095 Helix-turn-helix domains; Region: HTH; cl00088 1032480007096 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1032480007097 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1032480007098 active site 1032480007099 metal binding site [ion binding]; metal-binding site 1032480007100 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1032480007101 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 1032480007102 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1032480007103 active site 1032480007104 ADP/pyrophosphate binding site [chemical binding]; other site 1032480007105 dimerization interface [polypeptide binding]; other site 1032480007106 allosteric effector site; other site 1032480007107 fructose-1,6-bisphosphate binding site; other site 1032480007108 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1032480007109 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1032480007110 aromatic arch; other site 1032480007111 DCoH dimer interaction site [polypeptide binding]; other site 1032480007112 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1032480007113 DCoH tetramer interaction site [polypeptide binding]; other site 1032480007114 substrate binding site [chemical binding]; other site 1032480007115 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1032480007116 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480007117 motif II; other site 1032480007118 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1032480007119 DinB superfamily; Region: DinB_2; pfam12867 1032480007120 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 1032480007121 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 1032480007122 active site 1032480007123 ATP binding site [chemical binding]; other site 1032480007124 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480007125 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1032480007126 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1032480007127 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480007128 Walker A/P-loop; other site 1032480007129 ATP binding site [chemical binding]; other site 1032480007130 Q-loop/lid; other site 1032480007131 ABC transporter signature motif; other site 1032480007132 Walker B; other site 1032480007133 D-loop; other site 1032480007134 H-loop/switch region; other site 1032480007135 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1032480007136 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1032480007137 DNA binding residues [nucleotide binding] 1032480007138 drug binding residues [chemical binding]; other site 1032480007139 dimer interface [polypeptide binding]; other site 1032480007140 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480007141 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1032480007142 active site 1032480007143 metal binding site [ion binding]; metal-binding site 1032480007144 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1032480007145 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1032480007146 active site 1032480007147 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1032480007148 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1032480007149 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1032480007150 nudix motif; other site 1032480007151 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1032480007152 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1032480007153 active site 1032480007154 oxyanion hole [active] 1032480007155 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480007156 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480007157 DNA binding residues [nucleotide binding] 1032480007158 dimerization interface [polypeptide binding]; other site 1032480007159 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480007160 Walker A/P-loop; other site 1032480007161 ATP binding site [chemical binding]; other site 1032480007162 Q-loop/lid; other site 1032480007163 ABC transporter signature motif; other site 1032480007164 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14265 1032480007165 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480007166 ABC transporter signature motif; other site 1032480007167 Walker B; other site 1032480007168 D-loop; other site 1032480007169 H-loop/switch region; other site 1032480007170 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480007171 Walker A/P-loop; other site 1032480007172 ATP binding site [chemical binding]; other site 1032480007173 Q-loop/lid; other site 1032480007174 ABC transporter signature motif; other site 1032480007175 Walker B; other site 1032480007176 D-loop; other site 1032480007177 H-loop/switch region; other site 1032480007178 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1032480007179 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480007180 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1032480007181 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480007182 Phosphoesterase family; Region: Phosphoesterase; cl15450 1032480007183 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1032480007184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480007185 active site 1032480007186 phosphorylation site [posttranslational modification] 1032480007187 intermolecular recognition site; other site 1032480007188 dimerization interface [polypeptide binding]; other site 1032480007189 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1032480007190 DNA binding site [nucleotide binding] 1032480007191 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1032480007192 active site 1032480007193 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1032480007194 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1032480007195 dimer interface [polypeptide binding]; other site 1032480007196 phosphorylation site [posttranslational modification] 1032480007197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480007198 ATP binding site [chemical binding]; other site 1032480007199 Mg2+ binding site [ion binding]; other site 1032480007200 G-X-G motif; other site 1032480007201 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1032480007202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480007203 active site 1032480007204 phosphorylation site [posttranslational modification] 1032480007205 intermolecular recognition site; other site 1032480007206 dimerization interface [polypeptide binding]; other site 1032480007207 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1032480007208 DNA binding site [nucleotide binding] 1032480007209 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1032480007210 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1032480007211 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1032480007212 Ligand Binding Site [chemical binding]; other site 1032480007213 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1032480007214 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1032480007215 dimer interface [polypeptide binding]; other site 1032480007216 phosphorylation site [posttranslational modification] 1032480007217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480007218 ATP binding site [chemical binding]; other site 1032480007219 Mg2+ binding site [ion binding]; other site 1032480007220 G-X-G motif; other site 1032480007221 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1032480007222 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1032480007223 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1032480007224 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 1032480007225 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1032480007226 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1032480007227 DNA binding residues [nucleotide binding] 1032480007228 dimer interface [polypeptide binding]; other site 1032480007229 Dienelactone hydrolase family; Region: DLH; pfam01738 1032480007230 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1032480007231 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480007232 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1032480007233 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480007234 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480007235 DNA binding site [nucleotide binding] 1032480007236 domain linker motif; other site 1032480007237 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480007238 dimerization interface [polypeptide binding]; other site 1032480007239 ligand binding site [chemical binding]; other site 1032480007240 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1032480007241 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1032480007242 Metal-binding active site; metal-binding site 1032480007243 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480007244 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480007245 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1032480007246 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1032480007247 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480007248 Walker A/P-loop; other site 1032480007249 ATP binding site [chemical binding]; other site 1032480007250 Q-loop/lid; other site 1032480007251 ABC transporter signature motif; other site 1032480007252 Walker B; other site 1032480007253 D-loop; other site 1032480007254 H-loop/switch region; other site 1032480007255 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1032480007256 TM-ABC transporter signature motif; other site 1032480007257 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 1032480007258 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1032480007259 putative ligand binding site [chemical binding]; other site 1032480007260 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480007261 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1032480007262 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1032480007263 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1032480007264 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1032480007265 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1032480007266 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1032480007267 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1032480007268 synthetase active site [active] 1032480007269 NTP binding site [chemical binding]; other site 1032480007270 metal binding site [ion binding]; metal-binding site 1032480007271 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1032480007272 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1032480007273 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480007274 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1032480007275 active site 1032480007276 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1032480007277 Protein export membrane protein; Region: SecD_SecF; cl14618 1032480007278 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1032480007279 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1032480007280 Protein export membrane protein; Region: SecD_SecF; cl14618 1032480007281 Preprotein translocase subunit; Region: YajC; cl00806 1032480007282 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1032480007283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480007284 Walker A motif; other site 1032480007285 ATP binding site [chemical binding]; other site 1032480007286 Walker B motif; other site 1032480007287 arginine finger; other site 1032480007288 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1032480007289 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1032480007290 RuvA N terminal domain; Region: RuvA_N; pfam01330 1032480007291 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 1032480007292 active site 1032480007293 putative DNA-binding cleft [nucleotide binding]; other site 1032480007294 dimer interface [polypeptide binding]; other site 1032480007295 Transcriptional regulator; Region: Transcrip_reg; cl00361 1032480007296 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1032480007297 putative acyl-acceptor binding pocket; other site 1032480007298 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 1032480007299 fatty acyl-CoA reductase; Region: PLN02996 1032480007300 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480007301 NAD(P) binding site [chemical binding]; other site 1032480007302 active site 1032480007303 C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cd09071 1032480007304 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1032480007305 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1032480007306 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 1032480007307 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1032480007308 catalytic residues [active] 1032480007309 pseudaminic acid synthase; Region: PseI; TIGR03586 1032480007310 NeuB family; Region: NeuB; cl00496 1032480007311 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1032480007312 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480007313 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1032480007314 DNA binding residues [nucleotide binding] 1032480007315 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1032480007316 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1032480007317 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1032480007318 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480007319 motif II; other site 1032480007320 Protein of unknown function (DUF952); Region: DUF952; cl01393 1032480007321 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1032480007322 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1032480007323 putative active site [active] 1032480007324 oxyanion strand; other site 1032480007325 catalytic triad [active] 1032480007326 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 1032480007327 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1032480007328 putative active site pocket [active] 1032480007329 4-fold oligomerization interface [polypeptide binding]; other site 1032480007330 metal binding residues [ion binding]; metal-binding site 1032480007331 3-fold/trimer interface [polypeptide binding]; other site 1032480007332 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1032480007333 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480007334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480007335 homodimer interface [polypeptide binding]; other site 1032480007336 catalytic residue [active] 1032480007337 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 1032480007338 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480007339 ATP binding site [chemical binding]; other site 1032480007340 putative Mg++ binding site [ion binding]; other site 1032480007341 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480007342 nucleotide binding region [chemical binding]; other site 1032480007343 ATP-binding site [chemical binding]; other site 1032480007344 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 1032480007345 PglZ domain; Region: PglZ; pfam08665 1032480007346 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480007347 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480007348 Protein kinase domain; Region: Pkinase; pfam00069 1032480007349 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480007350 active site 1032480007351 ATP binding site [chemical binding]; other site 1032480007352 substrate binding site [chemical binding]; other site 1032480007353 activation loop (A-loop); other site 1032480007354 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 1032480007355 Protein of unknown function (DUF554); Region: DUF554; cl00784 1032480007356 AzlC protein; Region: AzlC; cl00570 1032480007357 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1032480007358 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 1032480007359 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1032480007360 putative deacylase active site [active] 1032480007361 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1032480007362 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 1032480007363 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1032480007364 generic binding surface II; other site 1032480007365 generic binding surface I; other site 1032480007366 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480007367 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 1032480007368 active site 1032480007369 ATP binding site [chemical binding]; other site 1032480007370 IMP cyclohydrolase-like protein; Region: IMP_cyclohyd; cl01330 1032480007371 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1032480007372 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480007373 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1032480007374 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1032480007375 AAA domain; Region: AAA_33; pfam13671 1032480007376 ATP-binding site [chemical binding]; other site 1032480007377 Gluconate-6-phosphate binding site [chemical binding]; other site 1032480007378 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1032480007379 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1032480007380 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480007381 Walker A/P-loop; other site 1032480007382 ATP binding site [chemical binding]; other site 1032480007383 Q-loop/lid; other site 1032480007384 ABC transporter signature motif; other site 1032480007385 Walker B; other site 1032480007386 D-loop; other site 1032480007387 H-loop/switch region; other site 1032480007388 potential frameshift: common BLAST hit: gi|284033185|ref|YP_003383116.1| ABC transporter transmembrane protein 1032480007389 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 1032480007390 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480007391 Q-loop/lid; other site 1032480007392 ABC transporter signature motif; other site 1032480007393 Walker B; other site 1032480007394 D-loop; other site 1032480007395 H-loop/switch region; other site 1032480007396 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1032480007397 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1032480007398 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480007399 active site 1032480007400 metal binding site [ion binding]; metal-binding site 1032480007401 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480007402 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1032480007403 DinB superfamily; Region: DinB_2; pfam12867 1032480007404 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480007405 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480007406 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480007407 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1032480007408 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1032480007409 catalytic triad [active] 1032480007410 sugar efflux transporter; Region: 2A0120; TIGR00899 1032480007411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480007412 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 1032480007413 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1032480007414 active site 1032480007415 Helix-turn-helix domains; Region: HTH; cl00088 1032480007416 DNA binding site [nucleotide binding] 1032480007417 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1032480007418 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1032480007419 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1032480007420 NAD(P) binding site [chemical binding]; other site 1032480007421 catalytic residues [active] 1032480007422 Protein of unknown function (DUF779); Region: DUF779; cl01432 1032480007423 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1032480007424 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1032480007425 kynureninase; Region: kynureninase; TIGR01814 1032480007426 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480007427 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480007428 catalytic residue [active] 1032480007429 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1032480007430 active site 1032480007431 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 1032480007432 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480007433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480007434 active site 1032480007435 phosphorylation site [posttranslational modification] 1032480007436 intermolecular recognition site; other site 1032480007437 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480007438 DNA binding residues [nucleotide binding] 1032480007439 dimerization interface [polypeptide binding]; other site 1032480007440 Histidine kinase; Region: HisKA_3; pfam07730 1032480007441 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1032480007442 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1032480007443 dimer interface [polypeptide binding]; other site 1032480007444 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1032480007445 intersubunit interface [polypeptide binding]; other site 1032480007446 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1032480007447 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1032480007448 active site 1032480007449 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1032480007450 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480007451 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1032480007452 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1032480007453 active site 1032480007454 dimer interface [polypeptide binding]; other site 1032480007455 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1032480007456 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1032480007457 active site 1032480007458 FMN binding site [chemical binding]; other site 1032480007459 substrate binding site [chemical binding]; other site 1032480007460 3Fe-4S cluster binding site [ion binding]; other site 1032480007461 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1032480007462 domain interface; other site 1032480007463 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1032480007464 Helix-turn-helix domains; Region: HTH; cl00088 1032480007465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480007466 metabolite-proton symporter; Region: 2A0106; TIGR00883 1032480007467 putative substrate translocation pore; other site 1032480007468 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 1032480007469 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1032480007470 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1032480007471 shikimate binding site; other site 1032480007472 NAD(P) binding site [chemical binding]; other site 1032480007473 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1032480007474 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1032480007475 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1032480007476 PYR/PP interface [polypeptide binding]; other site 1032480007477 dimer interface [polypeptide binding]; other site 1032480007478 TPP binding site [chemical binding]; other site 1032480007479 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1032480007480 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1032480007481 TPP-binding site [chemical binding]; other site 1032480007482 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 1032480007483 active site 1032480007484 citrylCoA binding site [chemical binding]; other site 1032480007485 oxalacetate binding site [chemical binding]; other site 1032480007486 coenzyme A binding site [chemical binding]; other site 1032480007487 catalytic triad [active] 1032480007488 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1032480007489 putative catalytic cysteine [active] 1032480007490 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1032480007491 active site 1032480007492 trimer interface [polypeptide binding]; other site 1032480007493 dimer interface [polypeptide binding]; other site 1032480007494 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1032480007495 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 1032480007496 ADP binding site [chemical binding]; other site 1032480007497 magnesium binding site [ion binding]; other site 1032480007498 putative shikimate binding site; other site 1032480007499 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1032480007500 active site 1032480007501 dimer interface [polypeptide binding]; other site 1032480007502 metal binding site [ion binding]; metal-binding site 1032480007503 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 1032480007504 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480007505 NAD(P) binding site [chemical binding]; other site 1032480007506 active site 1032480007507 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 1032480007508 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 1032480007509 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1032480007510 substrate binding site [chemical binding]; other site 1032480007511 active site 1032480007512 catalytic residues [active] 1032480007513 heterodimer interface [polypeptide binding]; other site 1032480007514 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1032480007515 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1032480007516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480007517 catalytic residue [active] 1032480007518 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1032480007519 active site 1032480007520 ribulose/triose binding site [chemical binding]; other site 1032480007521 phosphate binding site [ion binding]; other site 1032480007522 substrate (anthranilate) binding pocket [chemical binding]; other site 1032480007523 product (indole) binding pocket [chemical binding]; other site 1032480007524 anthranilate synthase component I; Provisional; Region: PRK13571 1032480007525 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1032480007526 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1032480007527 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 1032480007528 TIGR03085 family protein; Region: TIGR03085 1032480007529 Cobalt transport protein; Region: CbiQ; cl00463 1032480007530 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1032480007531 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 1032480007532 Walker A/P-loop; other site 1032480007533 ATP binding site [chemical binding]; other site 1032480007534 Q-loop/lid; other site 1032480007535 ABC transporter signature motif; other site 1032480007536 Walker B; other site 1032480007537 D-loop; other site 1032480007538 H-loop/switch region; other site 1032480007539 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1032480007540 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1032480007541 dimer interface [polypeptide binding]; other site 1032480007542 active site 1032480007543 AMP-binding enzyme; Region: AMP-binding; cl15778 1032480007544 acyl-CoA synthetase; Validated; Region: PRK07798 1032480007545 potential frameshift: common BLAST hit: gi|310640441|ref|YP_003945199.1| glycoside hydrolase, family 3 1032480007546 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1032480007547 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1032480007548 PA14 domain; Region: PA14; cl08459 1032480007549 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1032480007550 Fibronectin type III-like domain; Region: Fn3-like; cl15273 1032480007551 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1032480007552 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480007553 Helix-turn-helix domains; Region: HTH; cl00088 1032480007554 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 1032480007555 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1032480007556 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1032480007557 intersubunit interface [polypeptide binding]; other site 1032480007558 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1032480007559 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1032480007560 GatB domain; Region: GatB_Yqey; cl11497 1032480007561 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1032480007562 Amidase; Region: Amidase; cl11426 1032480007563 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 1032480007564 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1032480007565 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480007566 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1032480007567 Walker A/P-loop; other site 1032480007568 ATP binding site [chemical binding]; other site 1032480007569 Q-loop/lid; other site 1032480007570 ABC transporter signature motif; other site 1032480007571 Walker B; other site 1032480007572 D-loop; other site 1032480007573 H-loop/switch region; other site 1032480007574 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1032480007575 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480007576 ABC transporter signature motif; other site 1032480007577 Walker B; other site 1032480007578 D-loop; other site 1032480007579 H-loop/switch region; other site 1032480007580 Protein of unknown function (DUF1015); Region: DUF1015; cl01715 1032480007581 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1032480007582 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 1032480007583 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480007584 Walker A/P-loop; other site 1032480007585 ATP binding site [chemical binding]; other site 1032480007586 Q-loop/lid; other site 1032480007587 ABC transporter signature motif; other site 1032480007588 Walker B; other site 1032480007589 D-loop; other site 1032480007590 H-loop/switch region; other site 1032480007591 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1032480007592 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1032480007593 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1032480007594 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1032480007595 nucleotide binding pocket [chemical binding]; other site 1032480007596 K-X-D-G motif; other site 1032480007597 catalytic site [active] 1032480007598 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1032480007599 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1032480007600 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1032480007601 Dimer interface [polypeptide binding]; other site 1032480007602 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1032480007603 nucleoside/Zn binding site; other site 1032480007604 dimer interface [polypeptide binding]; other site 1032480007605 catalytic motif [active] 1032480007606 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1032480007607 CGNR zinc finger; Region: zf-CGNR; pfam11706 1032480007608 major facilitator superfamily transporter; Provisional; Region: PRK05122 1032480007609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480007610 putative substrate translocation pore; other site 1032480007611 Domain of unknown function DUF77; Region: DUF77; cl00307 1032480007612 UDP-glucose 4-epimerase; Region: PLN02240 1032480007613 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1032480007614 NAD binding site [chemical binding]; other site 1032480007615 homodimer interface [polypeptide binding]; other site 1032480007616 active site 1032480007617 substrate binding site [chemical binding]; other site 1032480007618 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1032480007619 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1032480007620 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1032480007621 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480007622 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 1032480007623 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480007624 catalytic residue [active] 1032480007625 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1032480007626 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1032480007627 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1032480007628 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1032480007629 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1032480007630 active site 1032480007631 catalytic site [active] 1032480007632 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1032480007633 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1032480007634 active site 1032480007635 homodimer interface [polypeptide binding]; other site 1032480007636 catalytic site [active] 1032480007637 acceptor binding site [chemical binding]; other site 1032480007638 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 1032480007639 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480007640 glycogen branching enzyme; Provisional; Region: PRK12313 1032480007641 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1032480007642 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1032480007643 active site 1032480007644 catalytic site [active] 1032480007645 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 1032480007646 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1032480007647 nudix motif; other site 1032480007648 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1032480007649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480007650 ATP binding site [chemical binding]; other site 1032480007651 Mg2+ binding site [ion binding]; other site 1032480007652 G-X-G motif; other site 1032480007653 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480007654 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480007655 active site 1032480007656 phosphorylation site [posttranslational modification] 1032480007657 intermolecular recognition site; other site 1032480007658 dimerization interface [polypeptide binding]; other site 1032480007659 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480007660 DNA binding residues [nucleotide binding] 1032480007661 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 1032480007662 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1032480007663 active site 1032480007664 substrate binding site [chemical binding]; other site 1032480007665 trimer interface [polypeptide binding]; other site 1032480007666 CoA binding site [chemical binding]; other site 1032480007667 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1032480007668 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480007669 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 1032480007670 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1032480007671 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1032480007672 phosphoglucomutase; Validated; Region: PRK07564 1032480007673 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1032480007674 active site 1032480007675 substrate binding site [chemical binding]; other site 1032480007676 metal binding site [ion binding]; metal-binding site 1032480007677 Phosphate transporter family; Region: PHO4; cl00396 1032480007678 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1032480007679 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1032480007680 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 1032480007681 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1032480007682 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 1032480007683 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 1032480007684 ligand binding site; other site 1032480007685 tetramer interface; other site 1032480007686 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1032480007687 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1032480007688 Helix-turn-helix domains; Region: HTH; cl00088 1032480007689 Bacterial PH domain; Region: DUF304; cl01348 1032480007690 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 1032480007691 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1032480007692 Walker A; other site 1032480007693 putative acyltransferase; Provisional; Region: PRK05790 1032480007694 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1032480007695 dimer interface [polypeptide binding]; other site 1032480007696 active site 1032480007697 Plant ATP synthase F0; Region: YMF19; cl07975 1032480007698 DivIVA protein; Region: DivIVA; pfam05103 1032480007699 Protein of unknown function DUF91; Region: DUF91; cl00709 1032480007700 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480007701 acyl-CoA esterase; Provisional; Region: PRK10673 1032480007702 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1032480007703 active site 1032480007704 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 1032480007705 Helix-turn-helix domains; Region: HTH; cl00088 1032480007706 putative transposase OrfB; Reviewed; Region: PHA02517 1032480007707 HTH-like domain; Region: HTH_21; pfam13276 1032480007708 Integrase core domain; Region: rve; cl01316 1032480007709 Integrase core domain; Region: rve_3; cl15866 1032480007710 potential protein location (hypothetical protein) that overlaps protein ( transposase orfB for insertion sequence element) 1032480007711 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480007712 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 1032480007713 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1032480007714 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 1032480007715 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1032480007716 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1032480007717 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 1032480007718 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1032480007719 alpha subunit interaction interface [polypeptide binding]; other site 1032480007720 Walker A motif; other site 1032480007721 ATP binding site [chemical binding]; other site 1032480007722 Walker B motif; other site 1032480007723 inhibitor binding site; inhibition site 1032480007724 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1032480007725 ATP synthase; Region: ATP-synt; cl00365 1032480007726 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 1032480007727 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1032480007728 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 1032480007729 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1032480007730 beta subunit interaction interface [polypeptide binding]; other site 1032480007731 Walker A motif; other site 1032480007732 ATP binding site [chemical binding]; other site 1032480007733 Walker B motif; other site 1032480007734 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1032480007735 Plant ATP synthase F0; Region: YMF19; cl07975 1032480007736 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1032480007737 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1032480007738 Plant ATP synthase F0; Region: YMF19; cl07975 1032480007739 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1032480007740 ATP synthase A chain; Region: ATP-synt_A; cl00413 1032480007741 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1032480007742 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1032480007743 Mg++ binding site [ion binding]; other site 1032480007744 putative catalytic motif [active] 1032480007745 substrate binding site [chemical binding]; other site 1032480007746 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1032480007747 UGMP family protein; Validated; Region: PRK09604 1032480007748 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 1032480007749 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1032480007750 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1032480007751 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 1032480007752 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 1032480007753 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1032480007754 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480007755 S-adenosylmethionine binding site [chemical binding]; other site 1032480007756 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1032480007757 RF-1 domain; Region: RF-1; cl02875 1032480007758 RF-1 domain; Region: RF-1; cl02875 1032480007759 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 1032480007760 transcription termination factor Rho; Provisional; Region: PRK12678 1032480007761 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1032480007762 transcription termination factor Rho; Provisional; Region: PRK12608 1032480007763 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1032480007764 RNA binding site [nucleotide binding]; other site 1032480007765 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480007766 Walker A motif; other site 1032480007767 ATP binding site [chemical binding]; other site 1032480007768 Walker B motif; other site 1032480007769 homoserine kinase; Provisional; Region: PRK01212 1032480007770 threonine synthase; Reviewed; Region: PRK06721 1032480007771 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1032480007772 homodimer interface [polypeptide binding]; other site 1032480007773 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480007774 catalytic residue [active] 1032480007775 homoserine dehydrogenase; Provisional; Region: PRK06349 1032480007776 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480007777 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1032480007778 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1032480007779 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1032480007780 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1032480007781 active site 1032480007782 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1032480007783 substrate binding site [chemical binding]; other site 1032480007784 catalytic residues [active] 1032480007785 dimer interface [polypeptide binding]; other site 1032480007786 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480007787 Phage capsid family; Region: Phage_capsid; pfam05065 1032480007788 Transcription factor WhiB; Region: Whib; pfam02467 1032480007789 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 1032480007790 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1032480007791 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1032480007792 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1032480007793 DNA binding site [nucleotide binding] 1032480007794 Int/Topo IB signature motif; other site 1032480007795 active site 1032480007796 Helix-turn-helix domains; Region: HTH; cl00088 1032480007797 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1032480007798 putative active site [active] 1032480007799 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1032480007800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480007801 dimer interface [polypeptide binding]; other site 1032480007802 conserved gate region; other site 1032480007803 putative PBP binding loops; other site 1032480007804 ABC-ATPase subunit interface; other site 1032480007805 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1032480007806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480007807 dimer interface [polypeptide binding]; other site 1032480007808 conserved gate region; other site 1032480007809 putative PBP binding loops; other site 1032480007810 ABC-ATPase subunit interface; other site 1032480007811 carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851 1032480007812 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480007813 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480007814 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1032480007815 Ferritin-like; Region: Ferritin-like; pfam12902 1032480007816 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 1032480007817 potential frameshift: common BLAST hit: gi|256824788|ref|YP_003148748.1| dimethyladenosine transferase (rRNA methylation) 1032480007818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480007819 S-adenosylmethionine binding site [chemical binding]; other site 1032480007820 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1032480007821 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1032480007822 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1032480007823 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 1032480007824 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1032480007825 TPP-binding site [chemical binding]; other site 1032480007826 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1032480007827 potential protein location (hypothetical protein) that overlaps protein (2-oxoglutarate dehydrogenase E1 component) 1032480007828 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 1032480007829 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1032480007830 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480007831 NAD(P) binding site [chemical binding]; other site 1032480007832 galactokinase; Provisional; Region: PRK05101 1032480007833 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1032480007834 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1032480007835 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1032480007836 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1032480007837 substrate binding pocket [chemical binding]; other site 1032480007838 membrane-bound complex binding site; other site 1032480007839 hinge residues; other site 1032480007840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480007841 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1032480007842 dimer interface [polypeptide binding]; other site 1032480007843 conserved gate region; other site 1032480007844 putative PBP binding loops; other site 1032480007845 ABC-ATPase subunit interface; other site 1032480007846 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1032480007847 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1032480007848 Walker A/P-loop; other site 1032480007849 ATP binding site [chemical binding]; other site 1032480007850 Q-loop/lid; other site 1032480007851 ABC transporter signature motif; other site 1032480007852 Walker B; other site 1032480007853 D-loop; other site 1032480007854 H-loop/switch region; other site 1032480007855 Transcription factor WhiB; Region: Whib; pfam02467 1032480007856 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1032480007857 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1032480007858 Histidine kinase; Region: HisKA_2; cl06527 1032480007859 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480007860 ATP binding site [chemical binding]; other site 1032480007861 Mg2+ binding site [ion binding]; other site 1032480007862 G-X-G motif; other site 1032480007863 Putative zinc-finger; Region: zf-HC2; cl15806 1032480007864 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1032480007865 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480007866 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1032480007867 DNA binding residues [nucleotide binding] 1032480007868 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 1032480007869 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1032480007870 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1032480007871 Helix-turn-helix domains; Region: HTH; cl00088 1032480007872 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1032480007873 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 1032480007874 hinge; other site 1032480007875 active site 1032480007876 Predicted GTPases [General function prediction only]; Region: COG1162 1032480007877 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1032480007878 RNA binding site [nucleotide binding]; other site 1032480007879 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1032480007880 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1032480007881 GTP/Mg2+ binding site [chemical binding]; other site 1032480007882 G4 box; other site 1032480007883 G1 box; other site 1032480007884 Switch I region; other site 1032480007885 G2 box; other site 1032480007886 G3 box; other site 1032480007887 Switch II region; other site 1032480007888 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1032480007889 active site 1032480007890 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 1032480007891 putative hydrophobic ligand binding site [chemical binding]; other site 1032480007892 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1032480007893 nudix motif; other site 1032480007894 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1032480007895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480007896 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1032480007897 L-serine binding site [chemical binding]; other site 1032480007898 ACT domain interface; other site 1032480007899 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1032480007900 putative active site pocket [active] 1032480007901 cleavage site 1032480007902 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1032480007903 Stage II sporulation protein; Region: SpoIID; pfam08486 1032480007904 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1032480007905 FG-GAP repeat; Region: FG-GAP; cl15299 1032480007906 Family description; Region: VCBS; pfam13517 1032480007907 Family description; Region: VCBS; pfam13517 1032480007908 Family description; Region: VCBS; pfam13517 1032480007909 FG-GAP repeat; Region: FG-GAP; cl15299 1032480007910 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480007911 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480007912 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1032480007913 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1032480007914 conserved cys residue [active] 1032480007915 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 1032480007916 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1032480007917 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1032480007918 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 1032480007919 Walker A/P-loop; other site 1032480007920 ATP binding site [chemical binding]; other site 1032480007921 Q-loop/lid; other site 1032480007922 ABC transporter signature motif; other site 1032480007923 Walker B; other site 1032480007924 D-loop; other site 1032480007925 H-loop/switch region; other site 1032480007926 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1032480007927 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1032480007928 Phage-related protein [Function unknown]; Region: COG5412 1032480007929 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1032480007930 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1032480007931 active site 1032480007932 substrate binding site [chemical binding]; other site 1032480007933 trimer interface [polypeptide binding]; other site 1032480007934 CoA binding site [chemical binding]; other site 1032480007935 UreD urease accessory protein; Region: UreD; cl00530 1032480007936 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480007937 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1032480007938 UreF; Region: UreF; pfam01730 1032480007939 urease subunit alpha; Reviewed; Region: ureC; PRK13206 1032480007940 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1032480007941 subunit interactions [polypeptide binding]; other site 1032480007942 active site 1032480007943 flap region; other site 1032480007944 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1032480007945 alpha-gamma subunit interface [polypeptide binding]; other site 1032480007946 beta-gamma subunit interface [polypeptide binding]; other site 1032480007947 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cl00533 1032480007948 alpha-beta subunit interface [polypeptide binding]; other site 1032480007949 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1032480007950 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 1032480007951 Uncharacterized conserved protein [Function unknown]; Region: COG5634 1032480007952 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 1032480007953 Lamin Tail Domain; Region: LTD; pfam00932 1032480007954 Predicted peptidase [General function prediction only]; Region: COG4099 1032480007955 short chain dehydrogenase; Provisional; Region: PRK06114 1032480007956 classical (c) SDRs; Region: SDR_c; cd05233 1032480007957 NAD(P) binding site [chemical binding]; other site 1032480007958 active site 1032480007959 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1032480007960 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1032480007961 molybdopterin cofactor binding site; other site 1032480007962 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1032480007963 molybdopterin cofactor binding site; other site 1032480007964 Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356 1032480007965 substrate binding site [chemical binding]; other site 1032480007966 Protein of unknown function (DUF521); Region: DUF521; pfam04412 1032480007967 Putative Aconitase X catalytic domain; Region: AcnX; cd01355 1032480007968 substrate binding site [chemical binding]; other site 1032480007969 ligand binding site [chemical binding]; other site 1032480007970 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1032480007971 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480007972 DNA-binding site [nucleotide binding]; DNA binding site 1032480007973 UTRA domain; Region: UTRA; cl01230 1032480007974 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1032480007975 FMN binding site [chemical binding]; other site 1032480007976 substrate binding site [chemical binding]; other site 1032480007977 putative catalytic residue [active] 1032480007978 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 1032480007979 putative active site [active] 1032480007980 putative metal binding residues [ion binding]; other site 1032480007981 signature motif; other site 1032480007982 putative dimer interface [polypeptide binding]; other site 1032480007983 putative phosphate binding site [ion binding]; other site 1032480007984 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480007985 Ligand Binding Site [chemical binding]; other site 1032480007986 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1032480007987 NMT1-like family; Region: NMT1_2; cl15260 1032480007988 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1032480007989 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 1032480007990 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1032480007991 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1032480007992 calcium binding site 2 [ion binding]; other site 1032480007993 active site 1032480007994 catalytic triad [active] 1032480007995 calcium binding site 1 [ion binding]; other site 1032480007996 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1032480007997 Interdomain contacts; other site 1032480007998 Cytokine receptor motif; other site 1032480007999 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1032480008000 Interdomain contacts; other site 1032480008001 Cytokine receptor motif; other site 1032480008002 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1032480008003 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1032480008004 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1032480008005 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 1032480008006 active site residue [active] 1032480008007 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1032480008008 putative homotetramer interface [polypeptide binding]; other site 1032480008009 putative homodimer interface [polypeptide binding]; other site 1032480008010 putative allosteric switch controlling residues; other site 1032480008011 putative metal binding site [ion binding]; other site 1032480008012 putative homodimer-homodimer interface [polypeptide binding]; other site 1032480008013 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 1032480008014 Helix-turn-helix domains; Region: HTH; cl00088 1032480008015 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1032480008016 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1032480008017 active site 1032480008018 SUMO-1 interface [polypeptide binding]; other site 1032480008019 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 1032480008020 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1032480008021 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1032480008022 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1032480008023 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1032480008024 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1032480008025 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1032480008026 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 1032480008027 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1032480008028 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1032480008029 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1032480008030 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1032480008031 MoaE homodimer interface [polypeptide binding]; other site 1032480008032 MoaD interaction [polypeptide binding]; other site 1032480008033 active site residues [active] 1032480008034 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 1032480008035 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837 1032480008036 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 1032480008037 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1032480008038 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480008039 NAD(P) binding site [chemical binding]; other site 1032480008040 active site 1032480008041 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1032480008042 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 1032480008043 DNA binding residues [nucleotide binding] 1032480008044 dimer interface [polypeptide binding]; other site 1032480008045 [2Fe-2S] cluster binding site [ion binding]; other site 1032480008046 Protein of unknown function DUF45; Region: DUF45; cl00636 1032480008047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480008048 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1032480008049 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480008050 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 1032480008051 active site 1032480008052 ATP binding site [chemical binding]; other site 1032480008053 Transcription factor WhiB; Region: Whib; pfam02467 1032480008054 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1032480008055 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480008056 Family description; Region: UvrD_C_2; cl15862 1032480008057 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1032480008058 HRDC domain; Region: HRDC; cl02578 1032480008059 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1032480008060 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480008061 Coenzyme A binding pocket [chemical binding]; other site 1032480008062 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1032480008063 catalytic residues [active] 1032480008064 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1032480008065 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480008066 motif II; other site 1032480008067 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1032480008068 Clp protease; Region: CLP_protease; pfam00574 1032480008069 oligomer interface [polypeptide binding]; other site 1032480008070 active site residues [active] 1032480008071 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1032480008072 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1032480008073 oligomer interface [polypeptide binding]; other site 1032480008074 active site residues [active] 1032480008075 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480008076 non-specific DNA binding site [nucleotide binding]; other site 1032480008077 salt bridge; other site 1032480008078 sequence-specific DNA binding site [nucleotide binding]; other site 1032480008079 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1032480008080 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1032480008081 DXD motif; other site 1032480008082 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1032480008083 NodB motif; other site 1032480008084 active site 1032480008085 catalytic site [active] 1032480008086 metal binding site [ion binding]; metal-binding site 1032480008087 OpgC protein; Region: OpgC_C; cl00792 1032480008088 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1032480008089 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1032480008090 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1032480008091 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1032480008092 glutaminase active site [active] 1032480008093 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1032480008094 dimer interface [polypeptide binding]; other site 1032480008095 active site 1032480008096 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1032480008097 dimer interface [polypeptide binding]; other site 1032480008098 active site 1032480008099 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 1032480008100 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1032480008101 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1032480008102 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1032480008103 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480008104 Family description; Region: UvrD_C_2; cl15862 1032480008105 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1032480008106 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480008107 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1032480008108 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1032480008109 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1032480008110 putative active site [active] 1032480008111 putative metal binding site [ion binding]; other site 1032480008112 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1032480008113 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1032480008114 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480008115 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480008116 DNA binding site [nucleotide binding] 1032480008117 domain linker motif; other site 1032480008118 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480008119 ligand binding site [chemical binding]; other site 1032480008120 dimerization interface [polypeptide binding]; other site 1032480008121 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 1032480008122 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1032480008123 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1032480008124 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1032480008125 putative NADH binding site [chemical binding]; other site 1032480008126 putative active site [active] 1032480008127 nudix motif; other site 1032480008128 putative metal binding site [ion binding]; other site 1032480008129 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1032480008130 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480008131 Family description; Region: UvrD_C_2; cl15862 1032480008132 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1032480008133 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1032480008134 Family description; Region: UvrD_C_2; cl15862 1032480008135 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1032480008136 PQQ-like domain; Region: PQQ_2; pfam13360 1032480008137 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1032480008138 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1032480008139 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1032480008140 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1032480008141 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1032480008142 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1032480008143 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480008144 motif II; other site 1032480008145 Cupin domain; Region: Cupin_2; cl09118 1032480008146 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1032480008147 DNA binding site [nucleotide binding] 1032480008148 active site 1032480008149 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1032480008150 DNA-binding site [nucleotide binding]; DNA binding site 1032480008151 RNA-binding motif; other site 1032480008152 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1032480008153 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1032480008154 ATP binding site [chemical binding]; other site 1032480008155 substrate interface [chemical binding]; other site 1032480008156 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1032480008157 active site residue [active] 1032480008158 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1032480008159 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 1032480008160 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1032480008161 dimer interface [polypeptide binding]; other site 1032480008162 putative anticodon binding site; other site 1032480008163 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 1032480008164 motif 1; other site 1032480008165 dimer interface [polypeptide binding]; other site 1032480008166 active site 1032480008167 motif 2; other site 1032480008168 motif 3; other site 1032480008169 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 1032480008170 nucleotide binding site [chemical binding]; other site 1032480008171 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480008172 Ligand Binding Site [chemical binding]; other site 1032480008173 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480008174 Helix-turn-helix domains; Region: HTH; cl00088 1032480008175 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1032480008176 Amidinotransferase; Region: Amidinotransf; cl12043 1032480008177 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1032480008178 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1032480008179 Spore germination protein; Region: Spore_permease; cl15802 1032480008180 amino acid transporter; Region: 2A0306; TIGR00909 1032480008181 Spore germination protein; Region: Spore_permease; cl15802 1032480008182 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1032480008183 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1032480008184 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480008185 Walker A motif; other site 1032480008186 ATP binding site [chemical binding]; other site 1032480008187 Walker B motif; other site 1032480008188 arginine finger; other site 1032480008189 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1032480008190 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1032480008191 substrate binding pocket [chemical binding]; other site 1032480008192 membrane-bound complex binding site; other site 1032480008193 hinge residues; other site 1032480008194 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1032480008195 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1032480008196 active site 1032480008197 ATP binding site [chemical binding]; other site 1032480008198 substrate binding site [chemical binding]; other site 1032480008199 activation loop (A-loop); other site 1032480008200 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1032480008201 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1032480008202 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1032480008203 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1032480008204 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1032480008205 tartrate dehydrogenase; Provisional; Region: PRK08194 1032480008206 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1032480008207 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1032480008208 PYR/PP interface [polypeptide binding]; other site 1032480008209 dimer interface [polypeptide binding]; other site 1032480008210 TPP binding site [chemical binding]; other site 1032480008211 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1032480008212 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1032480008213 TPP-binding site [chemical binding]; other site 1032480008214 dimer interface [polypeptide binding]; other site 1032480008215 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480008216 DNA binding site [nucleotide binding] 1032480008217 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1032480008218 OsmC-like protein; Region: OsmC; cl00767 1032480008219 META domain; Region: META; cl01245 1032480008220 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1032480008221 Predicted membrane protein [Function unknown]; Region: COG1511 1032480008222 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480008223 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1032480008224 Walker A/P-loop; other site 1032480008225 ATP binding site [chemical binding]; other site 1032480008226 Q-loop/lid; other site 1032480008227 ABC transporter signature motif; other site 1032480008228 Walker B; other site 1032480008229 D-loop; other site 1032480008230 H-loop/switch region; other site 1032480008231 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1032480008232 metal ion-dependent adhesion site (MIDAS); other site 1032480008233 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1032480008234 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1032480008235 phosphopeptide binding site; other site 1032480008236 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1032480008237 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 1032480008238 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1032480008239 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1032480008240 ATP binding site [chemical binding]; other site 1032480008241 Mg++ binding site [ion binding]; other site 1032480008242 motif III; other site 1032480008243 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480008244 nucleotide binding region [chemical binding]; other site 1032480008245 ATP-binding site [chemical binding]; other site 1032480008246 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1032480008247 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1032480008248 P-loop; other site 1032480008249 Magnesium ion binding site [ion binding]; other site 1032480008250 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1032480008251 Magnesium ion binding site [ion binding]; other site 1032480008252 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1032480008253 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1032480008254 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1032480008255 Uncharacterized membrane protein (DUF2298); Region: DUF2298; cl02250 1032480008256 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1032480008257 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1032480008258 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480008259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480008260 active site 1032480008261 phosphorylation site [posttranslational modification] 1032480008262 intermolecular recognition site; other site 1032480008263 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480008264 DNA binding residues [nucleotide binding] 1032480008265 Family description; Region: VCBS; pfam13517 1032480008266 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1032480008267 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1032480008268 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1032480008269 putative DNA binding site [nucleotide binding]; other site 1032480008270 putative homodimer interface [polypeptide binding]; other site 1032480008271 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1032480008272 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480008273 S-adenosylmethionine binding site [chemical binding]; other site 1032480008274 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1032480008275 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1032480008276 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1032480008277 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480008278 DNA-binding site [nucleotide binding]; DNA binding site 1032480008279 UTRA domain; Region: UTRA; cl01230 1032480008280 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 1032480008281 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1032480008282 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 1032480008283 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480008284 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13103 1032480008285 SEC-C motif; Region: SEC-C; pfam02810 1032480008286 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 1032480008287 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1032480008288 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1032480008289 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1032480008290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1032480008291 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1032480008292 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1032480008293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480008294 dimer interface [polypeptide binding]; other site 1032480008295 conserved gate region; other site 1032480008296 putative PBP binding loops; other site 1032480008297 ABC-ATPase subunit interface; other site 1032480008298 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1032480008299 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1032480008300 Walker A/P-loop; other site 1032480008301 ATP binding site [chemical binding]; other site 1032480008302 Q-loop/lid; other site 1032480008303 ABC transporter signature motif; other site 1032480008304 Walker B; other site 1032480008305 D-loop; other site 1032480008306 H-loop/switch region; other site 1032480008307 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1032480008308 Walker A/P-loop; other site 1032480008309 ATP binding site [chemical binding]; other site 1032480008310 Q-loop/lid; other site 1032480008311 ABC transporter signature motif; other site 1032480008312 Walker B; other site 1032480008313 D-loop; other site 1032480008314 H-loop/switch region; other site 1032480008315 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1032480008316 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 1032480008317 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480008318 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 1032480008319 TetR family transcriptional regulator; Provisional; Region: PRK14996 1032480008320 Helix-turn-helix domains; Region: HTH; cl00088 1032480008321 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 1032480008322 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 1032480008323 30S subunit binding site; other site 1032480008324 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1032480008325 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1032480008326 active site 1032480008327 lipoprotein LpqB; Provisional; Region: PRK13613 1032480008328 Sporulation and spore germination; Region: Germane; cl11253 1032480008329 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1032480008330 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1032480008331 dimer interface [polypeptide binding]; other site 1032480008332 phosphorylation site [posttranslational modification] 1032480008333 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480008334 ATP binding site [chemical binding]; other site 1032480008335 Mg2+ binding site [ion binding]; other site 1032480008336 G-X-G motif; other site 1032480008337 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1032480008338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480008339 active site 1032480008340 phosphorylation site [posttranslational modification] 1032480008341 intermolecular recognition site; other site 1032480008342 dimerization interface [polypeptide binding]; other site 1032480008343 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1032480008344 DNA binding site [nucleotide binding] 1032480008345 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 1032480008346 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1032480008347 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1032480008348 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1032480008349 putative NAD(P) binding site [chemical binding]; other site 1032480008350 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1032480008351 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1032480008352 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1032480008353 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480008354 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1032480008355 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480008356 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480008357 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1032480008358 metal ion-dependent adhesion site (MIDAS); other site 1032480008359 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480008360 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1032480008361 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1032480008362 dimer interface [polypeptide binding]; other site 1032480008363 TPP-binding site [chemical binding]; other site 1032480008364 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1032480008365 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480008366 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480008367 active site 1032480008368 substrate binding site [chemical binding]; other site 1032480008369 ATP binding site [chemical binding]; other site 1032480008370 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1032480008371 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1032480008372 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480008373 NAD(P) binding pocket [chemical binding]; other site 1032480008374 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 1032480008375 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505 1032480008376 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480008377 dihydropteroate synthase; Region: DHPS; TIGR01496 1032480008378 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1032480008379 substrate binding pocket [chemical binding]; other site 1032480008380 dimer interface [polypeptide binding]; other site 1032480008381 inhibitor binding site; inhibition site 1032480008382 Cupin domain; Region: Cupin_2; cl09118 1032480008383 Predicted transcriptional regulator [Transcription]; Region: COG2345 1032480008384 Helix-turn-helix domains; Region: HTH; cl00088 1032480008385 glutamate dehydrogenase; Provisional; Region: PRK09414 1032480008386 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1032480008387 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1032480008388 NAD(P) binding site [chemical binding]; other site 1032480008389 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 1032480008390 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480008391 Protein of unknown function, DUF488; Region: DUF488; cl01246 1032480008392 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1032480008393 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 1032480008394 Encapsulating protein for peroxidase; Region: Linocin_M18; cl12047 1032480008395 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1032480008396 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1032480008397 Tic20-like protein; Region: Tic20; pfam09685 1032480008398 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 1032480008399 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1032480008400 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1032480008401 SmpB-tmRNA interface; other site 1032480008402 Peptidase family M23; Region: Peptidase_M23; pfam01551 1032480008403 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1032480008404 FtsX-like permease family; Region: FtsX; cl15850 1032480008405 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1032480008406 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480008407 Walker A/P-loop; other site 1032480008408 ATP binding site [chemical binding]; other site 1032480008409 Q-loop/lid; other site 1032480008410 ABC transporter signature motif; other site 1032480008411 Walker B; other site 1032480008412 D-loop; other site 1032480008413 H-loop/switch region; other site 1032480008414 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1032480008415 Helix-turn-helix domains; Region: HTH; cl00088 1032480008416 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480008417 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480008418 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1032480008419 NAD(P) binding site [chemical binding]; other site 1032480008420 active site 1032480008421 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480008422 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480008423 DNA binding residues [nucleotide binding] 1032480008424 dimerization interface [polypeptide binding]; other site 1032480008425 2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate binding; Region: PLN02980 1032480008426 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480008427 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480008428 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1032480008429 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480008430 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1032480008431 RF-1 domain; Region: RF-1; cl02875 1032480008432 RF-1 domain; Region: RF-1; cl02875 1032480008433 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480008434 Walker A/P-loop; other site 1032480008435 ATP binding site [chemical binding]; other site 1032480008436 ABC transporter; Region: ABC_tran; pfam00005 1032480008437 Q-loop/lid; other site 1032480008438 ABC transporter signature motif; other site 1032480008439 Walker B; other site 1032480008440 D-loop; other site 1032480008441 H-loop/switch region; other site 1032480008442 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1032480008443 Family description; Region: UvrD_C_2; cl15862 1032480008444 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1032480008445 HipA N-terminal domain; Region: Couple_hipA; cl11853 1032480008446 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1032480008447 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1032480008448 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480008449 non-specific DNA binding site [nucleotide binding]; other site 1032480008450 salt bridge; other site 1032480008451 sequence-specific DNA binding site [nucleotide binding]; other site 1032480008452 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1032480008453 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480008454 Walker A motif; other site 1032480008455 ATP binding site [chemical binding]; other site 1032480008456 Walker B motif; other site 1032480008457 Integrase core domain; Region: rve; cl01316 1032480008458 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 1032480008459 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1032480008460 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1032480008461 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1032480008462 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1032480008463 active site 1032480008464 hypothetical protein; Provisional; Region: PRK07945 1032480008465 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1032480008466 Pirin-related protein [General function prediction only]; Region: COG1741 1032480008467 Cupin domain; Region: Cupin_2; cl09118 1032480008468 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1032480008469 Helix-turn-helix domains; Region: HTH; cl00088 1032480008470 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1032480008471 Helix-turn-helix domains; Region: HTH; cl00088 1032480008472 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1032480008473 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1032480008474 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1032480008475 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1032480008476 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1032480008477 dimer interface [polypeptide binding]; other site 1032480008478 active site 1032480008479 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1032480008480 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 1032480008481 putative active site [active] 1032480008482 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1032480008483 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1032480008484 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480008485 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1032480008486 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1032480008487 catalytic residue [active] 1032480008488 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1032480008489 metal ion-dependent adhesion site (MIDAS); other site 1032480008490 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1032480008491 metal ion-dependent adhesion site (MIDAS); other site 1032480008492 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1032480008493 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1032480008494 MoxR-like ATPases [General function prediction only]; Region: COG0714 1032480008495 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480008496 Walker A motif; other site 1032480008497 ATP binding site [chemical binding]; other site 1032480008498 Walker B motif; other site 1032480008499 arginine finger; other site 1032480008500 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480008501 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1032480008502 active site 1032480008503 motif I; other site 1032480008504 motif II; other site 1032480008505 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1032480008506 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1032480008507 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1032480008508 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1032480008509 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480008510 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1032480008511 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480008512 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1032480008513 Pyruvate formate lyase 1; Region: PFL1; cd01678 1032480008514 coenzyme A binding site [chemical binding]; other site 1032480008515 active site 1032480008516 catalytic residues [active] 1032480008517 glycine loop; other site 1032480008518 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1032480008519 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1032480008520 FeS/SAM binding site; other site 1032480008521 Helix-turn-helix domain; Region: HTH_18; pfam12833 1032480008522 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1032480008523 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1032480008524 active site 1032480008525 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1032480008526 putative substrate binding pocket [chemical binding]; other site 1032480008527 active site 1032480008528 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1032480008529 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 1032480008530 dimer interface [polypeptide binding]; other site 1032480008531 active site 1032480008532 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1032480008533 substrate binding site [chemical binding]; other site 1032480008534 catalytic residue [active] 1032480008535 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1032480008536 homotrimer interaction site [polypeptide binding]; other site 1032480008537 putative active site [active] 1032480008538 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1032480008539 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480008540 ATP binding site [chemical binding]; other site 1032480008541 Mg2+ binding site [ion binding]; other site 1032480008542 G-X-G motif; other site 1032480008543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 1032480008544 active site 1032480008545 phosphorylation site [posttranslational modification] 1032480008546 intermolecular recognition site; other site 1032480008547 two component system sensor kinase SsrB; Provisional; Region: PRK15369 1032480008548 dimerization interface [polypeptide binding]; other site 1032480008549 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1032480008550 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1032480008551 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1032480008552 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1032480008553 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1032480008554 active site 1032480008555 homotetramer interface [polypeptide binding]; other site 1032480008556 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 1032480008557 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1032480008558 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480008559 DNA primase; Validated; Region: dnaG; PRK05667 1032480008560 CHC2 zinc finger; Region: zf-CHC2; cl15369 1032480008561 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1032480008562 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1032480008563 active site 1032480008564 metal binding site [ion binding]; metal-binding site 1032480008565 interdomain interaction site; other site 1032480008566 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1032480008567 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 1032480008568 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1032480008569 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1032480008570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480008571 dimer interface [polypeptide binding]; other site 1032480008572 conserved gate region; other site 1032480008573 putative PBP binding loops; other site 1032480008574 ABC-ATPase subunit interface; other site 1032480008575 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1032480008576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480008577 dimer interface [polypeptide binding]; other site 1032480008578 conserved gate region; other site 1032480008579 putative PBP binding loops; other site 1032480008580 ABC-ATPase subunit interface; other site 1032480008581 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1032480008582 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480008583 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480008584 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480008585 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480008586 dimerization interface [polypeptide binding]; other site 1032480008587 ligand binding site [chemical binding]; other site 1032480008588 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1032480008589 dimer interface [polypeptide binding]; other site 1032480008590 putative radical transfer pathway; other site 1032480008591 diiron center [ion binding]; other site 1032480008592 tyrosyl radical; other site 1032480008593 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK06539 1032480008594 ATP cone domain; Region: ATP-cone; pfam03477 1032480008595 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1032480008596 active site 1032480008597 dimer interface [polypeptide binding]; other site 1032480008598 catalytic residues [active] 1032480008599 effector binding site; other site 1032480008600 R2 peptide binding site; other site 1032480008601 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1032480008602 active site 1032480008603 NTP binding site [chemical binding]; other site 1032480008604 metal binding triad [ion binding]; metal-binding site 1032480008605 antibiotic binding site [chemical binding]; other site 1032480008606 deoxyguanosinetriphosphate triphosphohydrolase, putative; Region: dGTP_triPase; TIGR01353 1032480008607 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1032480008608 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1032480008609 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1032480008610 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1032480008611 FMN binding site [chemical binding]; other site 1032480008612 active site 1032480008613 catalytic residues [active] 1032480008614 substrate binding site [chemical binding]; other site 1032480008615 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1032480008616 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 1032480008617 motif 1; other site 1032480008618 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 1032480008619 active site 1032480008620 motif 2; other site 1032480008621 motif 3; other site 1032480008622 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1032480008623 anticodon binding site; other site 1032480008624 Phospholipid methyltransferase; Region: PEMT; cl00763 1032480008625 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 1032480008626 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1032480008627 Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862 1032480008628 putative hydrophobic ligand binding site [chemical binding]; other site 1032480008629 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 1032480008630 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 1032480008631 active site 1032480008632 metal binding site [ion binding]; metal-binding site 1032480008633 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 1032480008634 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 1032480008635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480008636 S-adenosylmethionine binding site [chemical binding]; other site 1032480008637 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1032480008638 Peptidase family M23; Region: Peptidase_M23; pfam01551 1032480008639 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1032480008640 FAD binding domain; Region: FAD_binding_4; pfam01565 1032480008641 Berberine and berberine like; Region: BBE; pfam08031 1032480008642 Predicted ATPase [General function prediction only]; Region: COG3899 1032480008643 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480008644 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480008645 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480008646 DNA binding residues [nucleotide binding] 1032480008647 dimerization interface [polypeptide binding]; other site 1032480008648 YceI-like domain; Region: YceI; cl01001 1032480008649 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1032480008650 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; cl15460 1032480008651 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1032480008652 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1032480008653 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1032480008654 metal binding site [ion binding]; metal-binding site 1032480008655 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1032480008656 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 1032480008657 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1032480008658 ABC-ATPase subunit interface; other site 1032480008659 dimer interface [polypeptide binding]; other site 1032480008660 putative PBP binding regions; other site 1032480008661 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1032480008662 metal binding site 2 [ion binding]; metal-binding site 1032480008663 putative DNA binding helix; other site 1032480008664 metal binding site 1 [ion binding]; metal-binding site 1032480008665 dimer interface [polypeptide binding]; other site 1032480008666 structural Zn2+ binding site [ion binding]; other site 1032480008667 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 1032480008668 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480008669 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1032480008670 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1032480008671 catalytic residue [active] 1032480008672 putative FPP diphosphate binding site; other site 1032480008673 putative FPP binding hydrophobic cleft; other site 1032480008674 dimer interface [polypeptide binding]; other site 1032480008675 putative IPP diphosphate binding site; other site 1032480008676 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1032480008677 Recombination protein O N terminal; Region: RecO_N; cl15812 1032480008678 Recombination protein O C terminal; Region: RecO_C; pfam02565 1032480008679 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1032480008680 Zn binding site [ion binding]; other site 1032480008681 2-isopropylmalate synthase; Validated; Region: PRK03739 1032480008682 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1032480008683 active site 1032480008684 catalytic residues [active] 1032480008685 metal binding site [ion binding]; metal-binding site 1032480008686 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 1032480008687 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1032480008688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480008689 active site 1032480008690 phosphorylation site [posttranslational modification] 1032480008691 intermolecular recognition site; other site 1032480008692 dimerization interface [polypeptide binding]; other site 1032480008693 Helix-turn-helix domains; Region: HTH; cl00088 1032480008694 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1032480008695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1032480008696 Citrate transporter; Region: CitMHS; pfam03600 1032480008697 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1032480008698 transmembrane helices; other site 1032480008699 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480008700 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1032480008701 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1032480008702 putative active site [active] 1032480008703 catalytic site [active] 1032480008704 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 1032480008705 putative active site [active] 1032480008706 catalytic site [active] 1032480008707 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 1032480008708 GTPase Era; Reviewed; Region: era; PRK00089 1032480008709 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1032480008710 G1 box; other site 1032480008711 GTP/Mg2+ binding site [chemical binding]; other site 1032480008712 Switch I region; other site 1032480008713 G2 box; other site 1032480008714 Switch II region; other site 1032480008715 G3 box; other site 1032480008716 G4 box; other site 1032480008717 G5 box; other site 1032480008718 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 1032480008719 Domain of unknown function DUF21; Region: DUF21; pfam01595 1032480008720 FOG: CBS domain [General function prediction only]; Region: COG0517 1032480008721 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1032480008722 Transporter associated domain; Region: CorC_HlyC; cl08393 1032480008723 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 1032480008724 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1032480008725 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480008726 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 1032480008727 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1032480008728 intersubunit interface [polypeptide binding]; other site 1032480008729 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1032480008730 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 1032480008731 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1032480008732 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1032480008733 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480008734 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1032480008735 putative active site [active] 1032480008736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 1032480008737 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 1032480008738 chaperone protein DnaJ; Provisional; Region: PRK14278 1032480008739 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1032480008740 HSP70 interaction site [polypeptide binding]; other site 1032480008741 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1032480008742 Zn binding sites [ion binding]; other site 1032480008743 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1032480008744 dimer interface [polypeptide binding]; other site 1032480008745 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1032480008746 Helix-turn-helix domains; Region: HTH; cl00088 1032480008747 HrcA protein C terminal domain; Region: HrcA; pfam01628 1032480008748 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1032480008749 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480008750 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480008751 DNA binding site [nucleotide binding] 1032480008752 domain linker motif; other site 1032480008753 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1032480008754 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1032480008755 potential frameshift: common BLAST hit: gi|297626938|ref|YP_003688701.1| peptidase 1032480008756 Peptidase family M23; Region: Peptidase_M23; pfam01551 1032480008757 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1032480008758 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480008759 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480008760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480008761 active site 1032480008762 phosphorylation site [posttranslational modification] 1032480008763 intermolecular recognition site; other site 1032480008764 dimerization interface [polypeptide binding]; other site 1032480008765 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480008766 DNA binding residues [nucleotide binding] 1032480008767 dimerization interface [polypeptide binding]; other site 1032480008768 Histidine kinase; Region: HisKA_3; pfam07730 1032480008769 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1032480008770 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1032480008771 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1032480008772 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1032480008773 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1032480008774 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1032480008775 synthetase active site [active] 1032480008776 NTP binding site [chemical binding]; other site 1032480008777 metal binding site [ion binding]; metal-binding site 1032480008778 Spore coat assembly protein [Cell envelope biogenesis, outer membrane]; Region: CotH; COG5337 1032480008779 Helix-turn-helix domains; Region: HTH; cl00088 1032480008780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480008781 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480008782 putative substrate translocation pore; other site 1032480008783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480008784 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480008785 AAA domain; Region: AAA_18; pfam13238 1032480008786 active site 1032480008787 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1032480008788 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1032480008789 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1032480008790 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1032480008791 putative NAD(P) binding site [chemical binding]; other site 1032480008792 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1032480008793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 1032480008794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 1032480008795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 1032480008796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480008797 S-adenosylmethionine binding site [chemical binding]; other site 1032480008798 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1032480008799 Predicted ATPase [General function prediction only]; Region: COG3903 1032480008800 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480008801 GTP-binding protein LepA; Provisional; Region: PRK05433 1032480008802 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1032480008803 G1 box; other site 1032480008804 putative GEF interaction site [polypeptide binding]; other site 1032480008805 GTP/Mg2+ binding site [chemical binding]; other site 1032480008806 Switch I region; other site 1032480008807 G2 box; other site 1032480008808 G3 box; other site 1032480008809 Switch II region; other site 1032480008810 G4 box; other site 1032480008811 G5 box; other site 1032480008812 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1032480008813 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1032480008814 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1032480008815 Sodium:solute symporter family; Region: SSF; cl00456 1032480008816 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 1032480008817 OpgC protein; Region: OpgC_C; cl00792 1032480008818 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1032480008819 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480008820 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 1032480008821 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1032480008822 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1032480008823 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480008824 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480008825 active site 1032480008826 ATP binding site [chemical binding]; other site 1032480008827 Competence protein; Region: Competence; cl00471 1032480008828 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1032480008829 putative transposase OrfB; Reviewed; Region: PHA02517 1032480008830 HTH-like domain; Region: HTH_21; pfam13276 1032480008831 Integrase core domain; Region: rve; cl01316 1032480008832 Integrase core domain; Region: rve_3; cl15866 1032480008833 Helix-turn-helix domains; Region: HTH; cl00088 1032480008834 Competence protein; Region: Competence; cl00471 1032480008835 SLBB domain; Region: SLBB; pfam10531 1032480008836 comEA protein; Region: comE; TIGR01259 1032480008837 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1032480008838 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 1032480008839 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480008840 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1032480008841 putative catalytic site [active] 1032480008842 putative metal binding site [ion binding]; other site 1032480008843 putative phosphate binding site [ion binding]; other site 1032480008844 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1032480008845 catalytic core [active] 1032480008846 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1032480008847 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1032480008848 HIGH motif; other site 1032480008849 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1032480008850 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1032480008851 active site 1032480008852 KMSKS motif; other site 1032480008853 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1032480008854 tRNA binding surface [nucleotide binding]; other site 1032480008855 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480008856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480008857 putative substrate translocation pore; other site 1032480008858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480008859 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480008860 Helix-turn-helix domains; Region: HTH; cl00088 1032480008861 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1032480008862 Sulfate transporter family; Region: Sulfate_transp; cl15842 1032480008863 Sulfate transporter family; Region: Sulfate_transp; cl15842 1032480008864 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1032480008865 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1032480008866 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480008867 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480008868 catalytic residue [active] 1032480008869 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1032480008870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480008871 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1032480008872 NAD(P) binding site [chemical binding]; other site 1032480008873 active site 1032480008874 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 1032480008875 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1032480008876 nudix motif; other site 1032480008877 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480008878 dimerization interface [polypeptide binding]; other site 1032480008879 putative DNA binding site [nucleotide binding]; other site 1032480008880 putative Zn2+ binding site [ion binding]; other site 1032480008881 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1032480008882 putative hydrophobic ligand binding site [chemical binding]; other site 1032480008883 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 1032480008884 Nitrogen regulatory protein P-II; Region: P-II; cl00412 1032480008885 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1032480008886 [Protein-PII] uridylyltransferase; Region: UTase_glnD; TIGR01693 1032480008887 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1032480008888 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1032480008889 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1032480008890 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1032480008891 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1032480008892 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1032480008893 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1032480008894 putative substrate binding site [chemical binding]; other site 1032480008895 putative ATP binding site [chemical binding]; other site 1032480008896 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1032480008897 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1032480008898 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 1032480008899 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1032480008900 active site 1032480008901 catalytic residues [active] 1032480008902 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480008903 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480008904 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480008905 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480008906 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1032480008907 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480008908 active site 1032480008909 ATP binding site [chemical binding]; other site 1032480008910 substrate binding site [chemical binding]; other site 1032480008911 Rhomboid family; Region: Rhomboid; cl11446 1032480008912 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1032480008913 putative binding surface; other site 1032480008914 active site 1032480008915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480008916 Response regulator receiver domain; Region: Response_reg; pfam00072 1032480008917 active site 1032480008918 phosphorylation site [posttranslational modification] 1032480008919 intermolecular recognition site; other site 1032480008920 dimerization interface [polypeptide binding]; other site 1032480008921 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1032480008922 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1032480008923 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1032480008924 dimer interface [polypeptide binding]; other site 1032480008925 phosphorylation site [posttranslational modification] 1032480008926 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480008927 ATP binding site [chemical binding]; other site 1032480008928 Mg2+ binding site [ion binding]; other site 1032480008929 G-X-G motif; other site 1032480008930 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1032480008931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480008932 active site 1032480008933 phosphorylation site [posttranslational modification] 1032480008934 intermolecular recognition site; other site 1032480008935 dimerization interface [polypeptide binding]; other site 1032480008936 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1032480008937 DNA binding site [nucleotide binding] 1032480008938 benzoate transport; Region: 2A0115; TIGR00895 1032480008939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480008940 putative substrate translocation pore; other site 1032480008941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480008942 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480008943 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1032480008944 active site 1032480008945 catalytic residues [active] 1032480008946 TPR repeat; Region: TPR_11; pfam13414 1032480008947 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1032480008948 binding surface 1032480008949 TPR motif; other site 1032480008950 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1032480008951 CHAT domain; Region: CHAT; pfam12770 1032480008952 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480008953 Ligand Binding Site [chemical binding]; other site 1032480008954 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480008955 Ligand Binding Site [chemical binding]; other site 1032480008956 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1032480008957 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1032480008958 trimer interface [polypeptide binding]; other site 1032480008959 putative metal binding site [ion binding]; other site 1032480008960 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1032480008961 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480008962 active site 1032480008963 catalytic tetrad [active] 1032480008964 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1032480008965 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480008966 ATP binding site [chemical binding]; other site 1032480008967 putative Mg++ binding site [ion binding]; other site 1032480008968 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480008969 nucleotide binding region [chemical binding]; other site 1032480008970 ATP-binding site [chemical binding]; other site 1032480008971 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1032480008972 putative active site [active] 1032480008973 catalytic site [active] 1032480008974 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1032480008975 PLD-like domain; Region: PLDc_2; pfam13091 1032480008976 putative active site [active] 1032480008977 catalytic site [active] 1032480008978 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1032480008979 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1032480008980 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1032480008981 Cl- selectivity filter; other site 1032480008982 Cl- binding residues [ion binding]; other site 1032480008983 pore gating glutamate residue; other site 1032480008984 dimer interface [polypeptide binding]; other site 1032480008985 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1032480008986 tyramine oxidase; Provisional; Region: tynA; PRK11504 1032480008987 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 1032480008988 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 1032480008989 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 1032480008990 biotin carboxylase-like protein; Validated; Region: PRK06524 1032480008991 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1032480008992 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1032480008993 binding surface 1032480008994 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1032480008995 TPR motif; other site 1032480008996 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1032480008997 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1032480008998 tetramerization interface [polypeptide binding]; other site 1032480008999 NAD(P) binding site [chemical binding]; other site 1032480009000 catalytic residues [active] 1032480009001 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 1032480009002 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1032480009003 inhibitor-cofactor binding pocket; inhibition site 1032480009004 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480009005 catalytic residue [active] 1032480009006 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1032480009007 Helix-turn-helix domains; Region: HTH; cl00088 1032480009008 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1032480009009 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480009010 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480009011 catalytic residue [active] 1032480009012 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1032480009013 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1032480009014 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1032480009015 Amidohydrolase; Region: Amidohydro_4; pfam13147 1032480009016 active site 1032480009017 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1032480009018 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1032480009019 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1032480009020 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 1032480009021 active site 1032480009022 ATP binding site [chemical binding]; other site 1032480009023 substrate binding site [chemical binding]; other site 1032480009024 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 1032480009025 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480009026 ABC transporter signature motif; other site 1032480009027 Walker B; other site 1032480009028 D-loop; other site 1032480009029 H-loop/switch region; other site 1032480009030 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480009031 AAA domain; Region: AAA_21; pfam13304 1032480009032 Walker A/P-loop; other site 1032480009033 ATP binding site [chemical binding]; other site 1032480009034 Q-loop/lid; other site 1032480009035 ABC transporter signature motif; other site 1032480009036 Walker B; other site 1032480009037 D-loop; other site 1032480009038 H-loop/switch region; other site 1032480009039 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1032480009040 Helix-turn-helix domains; Region: HTH; cl00088 1032480009041 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480009042 dimerization interface [polypeptide binding]; other site 1032480009043 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480009044 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 1032480009045 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1032480009046 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1032480009047 iron-sulfur cluster [ion binding]; other site 1032480009048 [2Fe-2S] cluster binding site [ion binding]; other site 1032480009049 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1032480009050 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1032480009051 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1032480009052 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1032480009053 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1032480009054 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1032480009055 [4Fe-4S] binding site [ion binding]; other site 1032480009056 molybdopterin cofactor binding site; other site 1032480009057 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1032480009058 molybdopterin cofactor binding site; other site 1032480009059 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 1032480009060 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1032480009061 active site 1032480009062 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1032480009063 DNA binding site [nucleotide binding] 1032480009064 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1032480009065 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1032480009066 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1032480009067 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1032480009068 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 1032480009069 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1032480009070 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 1032480009071 Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423 1032480009072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480009073 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480009074 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480009075 DNA binding residues [nucleotide binding] 1032480009076 dimerization interface [polypeptide binding]; other site 1032480009077 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480009078 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1032480009079 potential protein location (hypothetical protein) that overlaps protein (peptidase S1 family protein) 1032480009080 MoxR-like ATPases [General function prediction only]; Region: COG0714 1032480009081 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480009082 Walker A motif; other site 1032480009083 ATP binding site [chemical binding]; other site 1032480009084 Walker B motif; other site 1032480009085 arginine finger; other site 1032480009086 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1032480009087 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1032480009088 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1032480009089 metal ion-dependent adhesion site (MIDAS); other site 1032480009090 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1032480009091 metal ion-dependent adhesion site (MIDAS); other site 1032480009092 VanZ like family; Region: VanZ; cl01971 1032480009093 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1032480009094 Predicted ATPase [General function prediction only]; Region: COG3899 1032480009095 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480009096 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1032480009097 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480009098 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480009099 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1032480009100 active site 1032480009101 Protein of unknown function (DUF429); Region: DUF429; cl12046 1032480009102 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1032480009103 synthetase active site [active] 1032480009104 NTP binding site [chemical binding]; other site 1032480009105 metal binding site [ion binding]; metal-binding site 1032480009106 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480009107 Histidine kinase; Region: HisKA_3; pfam07730 1032480009108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480009109 ATP binding site [chemical binding]; other site 1032480009110 Mg2+ binding site [ion binding]; other site 1032480009111 G-X-G motif; other site 1032480009112 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480009113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480009114 active site 1032480009115 phosphorylation site [posttranslational modification] 1032480009116 intermolecular recognition site; other site 1032480009117 dimerization interface [polypeptide binding]; other site 1032480009118 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480009119 DNA binding residues [nucleotide binding] 1032480009120 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1032480009121 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1032480009122 Predicted ATPase [General function prediction only]; Region: COG3903 1032480009123 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480009124 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1032480009125 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1032480009126 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480009127 S-adenosylmethionine binding site [chemical binding]; other site 1032480009128 YCII-related domain; Region: YCII; cl00999 1032480009129 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1032480009130 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480009131 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480009132 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1032480009133 NAD(P) binding site [chemical binding]; other site 1032480009134 active site 1032480009135 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480009136 Helix-turn-helix domains; Region: HTH; cl00088 1032480009137 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1032480009138 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480009139 Q-loop/lid; other site 1032480009140 ABC transporter signature motif; other site 1032480009141 Walker B; other site 1032480009142 D-loop; other site 1032480009143 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1032480009144 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1032480009145 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480009146 Walker A/P-loop; other site 1032480009147 ATP binding site [chemical binding]; other site 1032480009148 Q-loop/lid; other site 1032480009149 ABC transporter signature motif; other site 1032480009150 Walker B; other site 1032480009151 D-loop; other site 1032480009152 H-loop/switch region; other site 1032480009153 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1032480009154 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1032480009155 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480009156 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1032480009157 potential frameshift: common BLAST hit: gi|256391016|ref|YP_003112580.1| filamentation induced by cAMP protein Fic 1032480009158 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1032480009159 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480009160 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1032480009161 Restriction endonuclease [Defense mechanisms]; Region: COG3587 1032480009162 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480009163 Divergent AAA domain; Region: AAA_4; pfam04326 1032480009164 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1032480009165 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1032480009166 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480009167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480009168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480009169 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 1032480009170 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311 1032480009171 putative active site [active] 1032480009172 catalytic site [active] 1032480009173 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1032480009174 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480009175 ATP binding site [chemical binding]; other site 1032480009176 putative Mg++ binding site [ion binding]; other site 1032480009177 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480009178 nucleotide binding region [chemical binding]; other site 1032480009179 ATP-binding site [chemical binding]; other site 1032480009180 Protein of unknown function DUF262; Region: DUF262; cl14890 1032480009181 Helix-turn-helix domains; Region: HTH; cl00088 1032480009182 putative transposase OrfB; Reviewed; Region: PHA02517 1032480009183 HTH-like domain; Region: HTH_21; pfam13276 1032480009184 Integrase core domain; Region: rve; cl01316 1032480009185 Integrase core domain; Region: rve_3; cl15866 1032480009186 Protein of unknown function DUF262; Region: DUF262; cl14890 1032480009187 Protein of unknown function DUF262; Region: DUF262; cl14890 1032480009188 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 1032480009189 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1032480009190 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480009191 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1032480009192 Integrase core domain; Region: rve; cl01316 1032480009193 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480009194 AAA domain; Region: AAA_13; pfam13166 1032480009195 Walker A/P-loop; other site 1032480009196 ATP binding site [chemical binding]; other site 1032480009197 Q-loop/lid; other site 1032480009198 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480009199 ABC transporter signature motif; other site 1032480009200 Walker B; other site 1032480009201 D-loop; other site 1032480009202 H-loop/switch region; other site 1032480009203 cyanate transporter; Region: CynX; TIGR00896 1032480009204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480009205 putative substrate translocation pore; other site 1032480009206 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1032480009207 catalytic core [active] 1032480009208 Oligomerisation domain; Region: Oligomerisation; cl00519 1032480009209 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1032480009210 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1032480009211 active site 1032480009212 (T/H)XGH motif; other site 1032480009213 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1032480009214 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1032480009215 putative catalytic cysteine [active] 1032480009216 PQ loop repeat; Region: PQ-loop; cl12056 1032480009217 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1032480009218 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1032480009219 FAD binding pocket [chemical binding]; other site 1032480009220 FAD binding motif [chemical binding]; other site 1032480009221 phosphate binding motif [ion binding]; other site 1032480009222 NAD binding pocket [chemical binding]; other site 1032480009223 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1032480009224 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1032480009225 active site 1032480009226 DNA binding site [nucleotide binding] 1032480009227 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1032480009228 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1032480009229 Walker A/P-loop; other site 1032480009230 ATP binding site [chemical binding]; other site 1032480009231 Q-loop/lid; other site 1032480009232 ABC transporter signature motif; other site 1032480009233 Walker B; other site 1032480009234 D-loop; other site 1032480009235 H-loop/switch region; other site 1032480009236 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1032480009237 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1032480009238 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1032480009239 Walker A/P-loop; other site 1032480009240 ATP binding site [chemical binding]; other site 1032480009241 Q-loop/lid; other site 1032480009242 ABC transporter signature motif; other site 1032480009243 Walker B; other site 1032480009244 D-loop; other site 1032480009245 H-loop/switch region; other site 1032480009246 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1032480009247 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1032480009248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480009249 putative PBP binding loops; other site 1032480009250 dimer interface [polypeptide binding]; other site 1032480009251 ABC-ATPase subunit interface; other site 1032480009252 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1032480009253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480009254 dimer interface [polypeptide binding]; other site 1032480009255 conserved gate region; other site 1032480009256 putative PBP binding loops; other site 1032480009257 ABC-ATPase subunit interface; other site 1032480009258 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1032480009259 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1032480009260 peptide binding site [polypeptide binding]; other site 1032480009261 hypothetical protein; Provisional; Region: PRK06185 1032480009262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480009263 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480009264 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1032480009265 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1032480009266 homodimer interface [polypeptide binding]; other site 1032480009267 active site 1032480009268 TDP-binding site; other site 1032480009269 acceptor substrate-binding pocket; other site 1032480009270 gamma-glutamyl kinase; Provisional; Region: PRK05429 1032480009271 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1032480009272 nucleotide binding site [chemical binding]; other site 1032480009273 homotetrameric interface [polypeptide binding]; other site 1032480009274 putative phosphate binding site [ion binding]; other site 1032480009275 putative allosteric binding site; other site 1032480009276 PUA domain; Region: PUA; cl00607 1032480009277 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1032480009278 GTP1/OBG; Region: GTP1_OBG; pfam01018 1032480009279 Obg GTPase; Region: Obg; cd01898 1032480009280 G1 box; other site 1032480009281 GTP/Mg2+ binding site [chemical binding]; other site 1032480009282 Switch I region; other site 1032480009283 G2 box; other site 1032480009284 G3 box; other site 1032480009285 Switch II region; other site 1032480009286 G4 box; other site 1032480009287 G5 box; other site 1032480009288 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 1032480009289 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 1032480009290 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 1032480009291 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 1032480009292 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 1032480009293 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1032480009294 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480009295 dimerization interface [polypeptide binding]; other site 1032480009296 putative DNA binding site [nucleotide binding]; other site 1032480009297 putative Zn2+ binding site [ion binding]; other site 1032480009298 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1032480009299 active site 1032480009300 metal binding site [ion binding]; metal-binding site 1032480009301 ferredoxin-NADP+ reductase; Region: PLN02852 1032480009302 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480009303 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1032480009304 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1032480009305 homodimer interface [polypeptide binding]; other site 1032480009306 oligonucleotide binding site [chemical binding]; other site 1032480009307 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 1032480009308 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 1032480009309 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480009310 dimerization interface [polypeptide binding]; other site 1032480009311 putative DNA binding site [nucleotide binding]; other site 1032480009312 putative Zn2+ binding site [ion binding]; other site 1032480009313 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1032480009314 putative hydrophobic ligand binding site [chemical binding]; other site 1032480009315 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1032480009316 FAD binding domain; Region: FAD_binding_4; pfam01565 1032480009317 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1032480009318 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1032480009319 H+ Antiporter protein; Region: 2A0121; TIGR00900 1032480009320 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1032480009321 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 1032480009322 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1032480009323 B12 binding site [chemical binding]; other site 1032480009324 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1032480009325 FeS/SAM binding site; other site 1032480009326 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 1032480009327 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 1032480009328 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 1032480009329 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 1032480009330 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 1032480009331 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1032480009332 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 1032480009333 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 1032480009334 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1032480009335 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1032480009336 Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335 1032480009337 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1032480009338 Sulfatase; Region: Sulfatase; cl10460 1032480009339 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 1032480009340 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1032480009341 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1032480009342 UDP-N-acetylmuramate--alanine ligase; Region: murC; TIGR01082 1032480009343 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1032480009344 potential frameshift: common BLAST hit: gi|284029290|ref|YP_003379221.1| periplasmic binding protein 1032480009345 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1032480009346 intersubunit interface [polypeptide binding]; other site 1032480009347 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1032480009348 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1032480009349 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480009350 NAD(P) binding site [chemical binding]; other site 1032480009351 active site 1032480009352 Helix-turn-helix domains; Region: HTH; cl00088 1032480009353 Rrf2 family protein; Region: rrf2_super; TIGR00738 1032480009354 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 1032480009355 cofactor binding site; other site 1032480009356 metal binding site [ion binding]; metal-binding site 1032480009357 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 1032480009358 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1032480009359 active site 1032480009360 HIGH motif; other site 1032480009361 nucleotide binding site [chemical binding]; other site 1032480009362 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1032480009363 active site 1032480009364 KMSKS motif; other site 1032480009365 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1032480009366 tRNA binding surface [nucleotide binding]; other site 1032480009367 anticodon binding site; other site 1032480009368 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1032480009369 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1032480009370 putative active site [active] 1032480009371 catalytic triad [active] 1032480009372 putative dimer interface [polypeptide binding]; other site 1032480009373 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1032480009374 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1032480009375 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1032480009376 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 1032480009377 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480009378 Walker A motif; other site 1032480009379 ATP binding site [chemical binding]; other site 1032480009380 Walker B motif; other site 1032480009381 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1032480009382 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1032480009383 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1032480009384 oligomer interface [polypeptide binding]; other site 1032480009385 active site residues [active] 1032480009386 Clp protease; Region: CLP_protease; pfam00574 1032480009387 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1032480009388 oligomer interface [polypeptide binding]; other site 1032480009389 active site residues [active] 1032480009390 trigger factor; Provisional; Region: tig; PRK01490 1032480009391 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 1032480009392 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1032480009393 PAS domain S-box; Region: sensory_box; TIGR00229 1032480009394 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1032480009395 putative active site [active] 1032480009396 heme pocket [chemical binding]; other site 1032480009397 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1032480009398 dimer interface [polypeptide binding]; other site 1032480009399 phosphorylation site [posttranslational modification] 1032480009400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480009401 ATP binding site [chemical binding]; other site 1032480009402 Mg2+ binding site [ion binding]; other site 1032480009403 G-X-G motif; other site 1032480009404 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1032480009405 Ferritin-like; Region: Ferritin-like; pfam12902 1032480009406 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1032480009407 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480009408 active site 1032480009409 catalytic tetrad [active] 1032480009410 Uncharacterized conserved protein [Function unknown]; Region: COG3535 1032480009411 Protein of unknown function (DUF917); Region: DUF917; pfam06032 1032480009412 cyclase homology domain; Region: CHD; cd07302 1032480009413 nucleotidyl binding site; other site 1032480009414 metal binding site [ion binding]; metal-binding site 1032480009415 dimer interface [polypeptide binding]; other site 1032480009416 cyclase homology domain; Region: CHD; cd07302 1032480009417 dimer interface [polypeptide binding]; other site 1032480009418 nucleotidyl binding site; other site 1032480009419 metal binding site [ion binding]; metal-binding site 1032480009420 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480009421 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 1032480009422 Ferritin-like; Region: Ferritin-like; pfam12902 1032480009423 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1032480009424 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1032480009425 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1032480009426 active site 1032480009427 catalytic site [active] 1032480009428 DNA polymerase IV; Provisional; Region: PRK03348 1032480009429 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1032480009430 active site 1032480009431 DNA binding site [nucleotide binding] 1032480009432 Peptidase C26; Region: Peptidase_C26; pfam07722 1032480009433 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1032480009434 catalytic triad [active] 1032480009435 Protein of unknown function (DUF503); Region: DUF503; cl00669 1032480009436 CAAX protease self-immunity; Region: Abi; cl00558 1032480009437 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1032480009438 Histidine kinase; Region: HisKA_3; pfam07730 1032480009439 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480009440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480009441 active site 1032480009442 phosphorylation site [posttranslational modification] 1032480009443 intermolecular recognition site; other site 1032480009444 dimerization interface [polypeptide binding]; other site 1032480009445 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480009446 DNA binding residues [nucleotide binding] 1032480009447 dimerization interface [polypeptide binding]; other site 1032480009448 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1032480009449 active site 1032480009450 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480009451 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1032480009452 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1032480009453 putative DNA binding site [nucleotide binding]; other site 1032480009454 catalytic residue [active] 1032480009455 putative H2TH interface [polypeptide binding]; other site 1032480009456 putative catalytic residues [active] 1032480009457 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1032480009458 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1032480009459 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1032480009460 putative active site [active] 1032480009461 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1032480009462 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 1032480009463 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1032480009464 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1032480009465 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1032480009466 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1032480009467 Zn binding site [ion binding]; other site 1032480009468 Repair protein; Region: Repair_PSII; cl01535 1032480009469 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1032480009470 active site 1032480009471 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1032480009472 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1032480009473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480009474 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1032480009475 dihydroorotase; Validated; Region: pyrC; PRK09357 1032480009476 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1032480009477 active site 1032480009478 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1032480009479 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1032480009480 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1032480009481 active site 1032480009482 dimerization interface [polypeptide binding]; other site 1032480009483 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1032480009484 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1032480009485 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480009486 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1032480009487 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1032480009488 active site 1032480009489 OsmC-like protein; Region: OsmC; cl00767 1032480009490 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1032480009491 apolar tunnel; other site 1032480009492 heme binding site [chemical binding]; other site 1032480009493 dimerization interface [polypeptide binding]; other site 1032480009494 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480009495 Helix-turn-helix domains; Region: HTH; cl00088 1032480009496 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1032480009497 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480009498 NAD(P) binding site [chemical binding]; other site 1032480009499 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1032480009500 active site 1032480009501 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1032480009502 active site 1032480009503 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480009504 NAD(P) binding site [chemical binding]; other site 1032480009505 active site 1032480009506 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1032480009507 AMP-binding enzyme; Region: AMP-binding; cl15778 1032480009508 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 1032480009509 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1032480009510 dimer interface [polypeptide binding]; other site 1032480009511 active site 1032480009512 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1032480009513 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1032480009514 active site 1032480009515 YceI-like domain; Region: YceI; cl01001 1032480009516 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1032480009517 Helix-turn-helix domains; Region: HTH; cl00088 1032480009518 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1032480009519 FAD binding domain; Region: FAD_binding_4; pfam01565 1032480009520 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1032480009521 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1032480009522 FAD binding pocket [chemical binding]; other site 1032480009523 conserved FAD binding motif [chemical binding]; other site 1032480009524 phosphate binding motif [ion binding]; other site 1032480009525 beta-alpha-beta structure motif; other site 1032480009526 NAD binding pocket [chemical binding]; other site 1032480009527 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1032480009528 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480009529 Walker A/P-loop; other site 1032480009530 ATP binding site [chemical binding]; other site 1032480009531 Q-loop/lid; other site 1032480009532 ABC transporter signature motif; other site 1032480009533 Walker B; other site 1032480009534 D-loop; other site 1032480009535 H-loop/switch region; other site 1032480009536 ABC transporter; Region: ABC_tran_2; pfam12848 1032480009537 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1032480009538 FOG: CBS domain [General function prediction only]; Region: COG0517 1032480009539 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1032480009540 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1032480009541 dimer interface [polypeptide binding]; other site 1032480009542 ssDNA binding site [nucleotide binding]; other site 1032480009543 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1032480009544 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1032480009545 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480009546 G1 box; other site 1032480009547 GTP/Mg2+ binding site [chemical binding]; other site 1032480009548 G2 box; other site 1032480009549 Switch I region; other site 1032480009550 G3 box; other site 1032480009551 Switch II region; other site 1032480009552 G4 box; other site 1032480009553 G5 box; other site 1032480009554 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1032480009555 G1 box; other site 1032480009556 GTP/Mg2+ binding site [chemical binding]; other site 1032480009557 G2 box; other site 1032480009558 Switch I region; other site 1032480009559 G3 box; other site 1032480009560 Switch II region; other site 1032480009561 Protease prsW family; Region: PrsW-protease; cl15823 1032480009562 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480009563 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480009564 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; cl02047 1032480009565 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480009566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480009567 putative substrate translocation pore; other site 1032480009568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480009569 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1032480009570 putative active site [active] 1032480009571 putative substrate binding site [chemical binding]; other site 1032480009572 catalytic site [active] 1032480009573 dimer interface [polypeptide binding]; other site 1032480009574 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1032480009575 catalytic residues [active] 1032480009576 catalytic nucleophile [active] 1032480009577 Recombinase; Region: Recombinase; pfam07508 1032480009578 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1032480009579 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1032480009580 dimer interface [polypeptide binding]; other site 1032480009581 ssDNA binding site [nucleotide binding]; other site 1032480009582 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1032480009583 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480009584 Walker A motif; other site 1032480009585 ATP binding site [chemical binding]; other site 1032480009586 Walker B motif; other site 1032480009587 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1032480009588 DNA binding site [nucleotide binding] 1032480009589 Int/Topo IB signature motif; other site 1032480009590 active site 1032480009591 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480009592 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1032480009593 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1032480009594 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1032480009595 catalytic residues [active] 1032480009596 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1032480009597 Membrane transport protein; Region: Mem_trans; cl09117 1032480009598 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480009599 putative DNA binding site [nucleotide binding]; other site 1032480009600 putative Zn2+ binding site [ion binding]; other site 1032480009601 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1032480009602 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1032480009603 active site 1032480009604 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1032480009605 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1032480009606 active site 1032480009607 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1032480009608 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1032480009609 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480009610 dimerization interface [polypeptide binding]; other site 1032480009611 putative DNA binding site [nucleotide binding]; other site 1032480009612 putative Zn2+ binding site [ion binding]; other site 1032480009613 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1032480009614 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480009615 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480009616 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1032480009617 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480009618 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 1032480009619 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480009620 dimerization interface [polypeptide binding]; other site 1032480009621 putative DNA binding site [nucleotide binding]; other site 1032480009622 putative Zn2+ binding site [ion binding]; other site 1032480009623 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1032480009624 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480009625 AAA-like domain; Region: AAA_10; pfam12846 1032480009626 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 1032480009627 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1032480009628 CGNR zinc finger; Region: zf-CGNR; pfam11706 1032480009629 H+ Antiporter protein; Region: 2A0121; TIGR00900 1032480009630 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 1032480009631 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1032480009632 active site 1032480009633 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1032480009634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480009635 S-adenosylmethionine binding site [chemical binding]; other site 1032480009636 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480009637 dimerization interface [polypeptide binding]; other site 1032480009638 putative DNA binding site [nucleotide binding]; other site 1032480009639 putative Zn2+ binding site [ion binding]; other site 1032480009640 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480009641 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1032480009642 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1032480009643 DNA binding site [nucleotide binding] 1032480009644 Int/Topo IB signature motif; other site 1032480009645 active site 1032480009646 Peptidase family M23; Region: Peptidase_M23; pfam01551 1032480009647 ParB-like nuclease domain; Region: ParBc; cl02129 1032480009648 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 1032480009649 Helix-turn-helix domains; Region: HTH; cl00088 1032480009650 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1032480009651 polymerase nucleotide-binding site; other site 1032480009652 DNA-binding residues [nucleotide binding]; DNA binding site 1032480009653 nucleotide binding site [chemical binding]; other site 1032480009654 primase nucleotide-binding site [nucleotide binding]; other site 1032480009655 Domain of unknown function (DUF955); Region: DUF955; cl01076 1032480009656 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480009657 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1032480009658 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1032480009659 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1032480009660 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1032480009661 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1032480009662 metal-binding site [ion binding] 1032480009663 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1032480009664 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1032480009665 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1032480009666 Domain of unknown function (DUF305); Region: DUF305; cl15795 1032480009667 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 1032480009668 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 1032480009669 cofactor binding site; other site 1032480009670 DNA binding site [nucleotide binding] 1032480009671 substrate interaction site [chemical binding]; other site 1032480009672 TrwC relaxase; Region: TrwC; pfam08751 1032480009673 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 1032480009674 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480009675 AAA domain; Region: AAA_22; pfam13401 1032480009676 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709 1032480009677 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480009678 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1032480009679 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480009680 recombination factor protein RarA; Reviewed; Region: PRK13342 1032480009681 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480009682 Walker A motif; other site 1032480009683 ATP binding site [chemical binding]; other site 1032480009684 Walker B motif; other site 1032480009685 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1032480009686 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 1032480009687 Protein of unknown function, DUF488; Region: DUF488; cl01246 1032480009688 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1032480009689 homotrimer interaction site [polypeptide binding]; other site 1032480009690 putative active site [active] 1032480009691 Predicted transcriptional regulator [Transcription]; Region: COG2378 1032480009692 Helix-turn-helix domains; Region: HTH; cl00088 1032480009693 WYL domain; Region: WYL; cl14852 1032480009694 potential frameshift: common BLAST hit: gi|308176205|ref|YP_003915611.1| smf family protein 1032480009695 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1032480009696 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1032480009697 Helix-turn-helix domains; Region: HTH; cl00088 1032480009698 DNA-binding interface [nucleotide binding]; DNA binding site 1032480009699 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1032480009700 catalytic residues [active] 1032480009701 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480009702 salt bridge; other site 1032480009703 non-specific DNA binding site [nucleotide binding]; other site 1032480009704 sequence-specific DNA binding site [nucleotide binding]; other site 1032480009705 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1032480009706 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 1032480009707 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1032480009708 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1032480009709 PA14 domain; Region: PA14; cl08459 1032480009710 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1032480009711 Fibronectin type III-like domain; Region: Fn3-like; cl15273 1032480009712 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1032480009713 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480009714 NAD(P) binding site [chemical binding]; other site 1032480009715 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480009716 non-specific DNA binding site [nucleotide binding]; other site 1032480009717 salt bridge; other site 1032480009718 sequence-specific DNA binding site [nucleotide binding]; other site 1032480009719 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1032480009720 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 1032480009721 putative NAD(P) binding site [chemical binding]; other site 1032480009722 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480009723 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 1032480009724 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 1032480009725 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 1032480009726 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480009727 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480009728 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1032480009729 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1032480009730 DNA binding site [nucleotide binding] 1032480009731 Int/Topo IB signature motif; other site 1032480009732 active site 1032480009733 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 1032480009734 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1032480009735 Divergent AAA domain; Region: AAA_4; pfam04326 1032480009736 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1032480009737 Helix-turn-helix domains; Region: HTH; cl00088 1032480009738 TIGR02687 family protein; Region: TIGR02687 1032480009739 PglZ domain; Region: PglZ; pfam08665 1032480009740 Putative ATP-dependent Lon protease; Region: Lon_2; cl11979 1032480009741 MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown; Region: MIT_C; cd02685 1032480009742 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1032480009743 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1032480009744 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480009745 Helix-turn-helix domains; Region: HTH; cl00088 1032480009746 putative transposase OrfB; Reviewed; Region: PHA02517 1032480009747 HTH-like domain; Region: HTH_21; pfam13276 1032480009748 Integrase core domain; Region: rve; cl01316 1032480009749 Integrase core domain; Region: rve_3; cl15866 1032480009750 Helix-turn-helix domains; Region: HTH; cl00088 1032480009751 putative transposase OrfB; Reviewed; Region: PHA02517 1032480009752 HTH-like domain; Region: HTH_21; pfam13276 1032480009753 Integrase core domain; Region: rve; cl01316 1032480009754 Integrase core domain; Region: rve_3; cl15866 1032480009755 Domain of unknown function DUF87; Region: DUF87; pfam01935 1032480009756 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1032480009757 LabA_like proteins; Region: LabA_like; cd06167 1032480009758 putative metal binding site [ion binding]; other site 1032480009759 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1032480009760 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480009761 DNA-binding site [nucleotide binding]; DNA binding site 1032480009762 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480009763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480009764 homodimer interface [polypeptide binding]; other site 1032480009765 catalytic residue [active] 1032480009766 LysE type translocator; Region: LysE; cl00565 1032480009767 Helix-turn-helix domains; Region: HTH; cl00088 1032480009768 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1032480009769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480009770 NAD(P) binding site [chemical binding]; other site 1032480009771 Helix-turn-helix domain; Region: HTH_18; pfam12833 1032480009772 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 1032480009773 Cupin domain; Region: Cupin_2; cl09118 1032480009774 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1032480009775 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480009776 short chain dehydrogenase; Provisional; Region: PRK06179 1032480009777 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1032480009778 NADP binding site [chemical binding]; other site 1032480009779 active site 1032480009780 steroid binding site; other site 1032480009781 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1032480009782 NAD(P) binding site [chemical binding]; other site 1032480009783 catalytic residues [active] 1032480009784 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1032480009785 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1032480009786 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480009787 Helix-turn-helix domains; Region: HTH; cl00088 1032480009788 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1032480009789 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480009790 putative DNA binding site [nucleotide binding]; other site 1032480009791 putative Zn2+ binding site [ion binding]; other site 1032480009792 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1032480009793 putative hydrophobic ligand binding site [chemical binding]; other site 1032480009794 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1032480009795 Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_3; cd04327 1032480009796 active site 1032480009797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480009798 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 1032480009799 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1032480009800 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1032480009801 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480009802 Walker A/P-loop; other site 1032480009803 ATP binding site [chemical binding]; other site 1032480009804 Q-loop/lid; other site 1032480009805 ABC transporter signature motif; other site 1032480009806 Walker B; other site 1032480009807 D-loop; other site 1032480009808 H-loop/switch region; other site 1032480009809 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 1032480009810 Helix-turn-helix domains; Region: HTH; cl00088 1032480009811 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1032480009812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480009813 putative substrate translocation pore; other site 1032480009814 Histidine kinase; Region: HisKA_3; pfam07730 1032480009815 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480009816 ATP binding site [chemical binding]; other site 1032480009817 Mg2+ binding site [ion binding]; other site 1032480009818 G-X-G motif; other site 1032480009819 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480009820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480009821 active site 1032480009822 phosphorylation site [posttranslational modification] 1032480009823 intermolecular recognition site; other site 1032480009824 dimerization interface [polypeptide binding]; other site 1032480009825 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480009826 DNA binding residues [nucleotide binding] 1032480009827 dimerization interface [polypeptide binding]; other site 1032480009828 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1032480009829 Dak1 domain; Region: Dak1; pfam02733 1032480009830 DAK2 domain; Region: Dak2; cl03685 1032480009831 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1032480009832 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK13779 1032480009833 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 1032480009834 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1032480009835 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1032480009836 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1032480009837 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1032480009838 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1032480009839 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1032480009840 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1032480009841 catalytic triad [active] 1032480009842 YhhN-like protein; Region: YhhN; cl01505 1032480009843 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480009844 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480009845 active site 1032480009846 catalytic tetrad [active] 1032480009847 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1032480009848 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480009849 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1032480009850 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480009851 ATP binding site [chemical binding]; other site 1032480009852 putative Mg++ binding site [ion binding]; other site 1032480009853 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480009854 nucleotide binding region [chemical binding]; other site 1032480009855 ATP-binding site [chemical binding]; other site 1032480009856 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1032480009857 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480009858 active site 1032480009859 catalytic tetrad [active] 1032480009860 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1032480009861 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1032480009862 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1032480009863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480009864 dimer interface [polypeptide binding]; other site 1032480009865 conserved gate region; other site 1032480009866 ABC-ATPase subunit interface; other site 1032480009867 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1032480009868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1032480009869 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1032480009870 oligomerisation interface [polypeptide binding]; other site 1032480009871 mobile loop; other site 1032480009872 roof hairpin; other site 1032480009873 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1032480009874 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1032480009875 Helix-turn-helix domains; Region: HTH; cl00088 1032480009876 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1032480009877 catalytic triad [active] 1032480009878 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1032480009879 amphipathic channel; other site 1032480009880 Asn-Pro-Ala signature motifs; other site 1032480009881 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1032480009882 folate binding site [chemical binding]; other site 1032480009883 NADP+ binding site [chemical binding]; other site 1032480009884 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1032480009885 dimerization interface [polypeptide binding]; other site 1032480009886 active site 1032480009887 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1032480009888 active site 1032480009889 dimerization interface [polypeptide binding]; other site 1032480009890 ribonuclease PH; Reviewed; Region: rph; PRK00173 1032480009891 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1032480009892 hexamer interface [polypeptide binding]; other site 1032480009893 active site 1032480009894 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1032480009895 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1032480009896 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1032480009897 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480009898 DNA-binding site [nucleotide binding]; DNA binding site 1032480009899 UTRA domain; Region: UTRA; cl01230 1032480009900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 1032480009901 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1032480009902 active site 1032480009903 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1032480009904 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1032480009905 substrate binding site [chemical binding]; other site 1032480009906 dimer interface [polypeptide binding]; other site 1032480009907 ATP binding site [chemical binding]; other site 1032480009908 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1032480009909 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1032480009910 TIGR03086 family protein; Region: TIGR03086 1032480009911 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1032480009912 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1032480009913 dimer interface [polypeptide binding]; other site 1032480009914 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480009915 catalytic residue [active] 1032480009916 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1032480009917 MoaE interaction surface [polypeptide binding]; other site 1032480009918 MoeB interaction surface [polypeptide binding]; other site 1032480009919 thiocarboxylated glycine; other site 1032480009920 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1032480009921 MPN+ (JAMM) motif; other site 1032480009922 Zinc-binding site [ion binding]; other site 1032480009923 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1032480009924 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 1032480009925 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 1032480009926 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1032480009927 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1032480009928 active site 1032480009929 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1032480009930 catalytic triad [active] 1032480009931 metal binding site [ion binding]; metal-binding site 1032480009932 conserved cis-peptide bond; other site 1032480009933 short chain dehydrogenase; Provisional; Region: PRK06197 1032480009934 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1032480009935 putative NAD(P) binding site [chemical binding]; other site 1032480009936 active site 1032480009937 Peptidase S8 family domain, uncharacterized subfamily 12; Region: Peptidases_S8_12; cd07480 1032480009938 active site 1032480009939 catalytic triad [active] 1032480009940 Cupin domain; Region: Cupin_2; cl09118 1032480009941 Protein of unknown function (DUF419); Region: DUF419; cl15265 1032480009942 fumarylacetoacetase; Region: PLN02856 1032480009943 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 1032480009944 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1032480009945 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1032480009946 RDD family; Region: RDD; cl00746 1032480009947 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1032480009948 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1032480009949 dimer interface [polypeptide binding]; other site 1032480009950 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1032480009951 active site 1032480009952 Fe binding site [ion binding]; other site 1032480009953 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1032480009954 Helix-turn-helix domains; Region: HTH; cl00088 1032480009955 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1032480009956 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1032480009957 active site 1032480009958 ATP binding site [chemical binding]; other site 1032480009959 substrate binding site [chemical binding]; other site 1032480009960 activation loop (A-loop); other site 1032480009961 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1032480009962 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480009963 ATP binding site [chemical binding]; other site 1032480009964 putative Mg++ binding site [ion binding]; other site 1032480009965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480009966 putative substrate translocation pore; other site 1032480009967 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1032480009968 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1032480009969 catalytic core [active] 1032480009970 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1032480009971 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1032480009972 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 1032480009973 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1032480009974 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 1032480009975 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 1032480009976 Adenosylhomocysteinase; Provisional; Region: PTZ00075 1032480009977 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401 1032480009978 oligomerization interface [polypeptide binding]; other site 1032480009979 active site 1032480009980 NAD+ binding site [chemical binding]; other site 1032480009981 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 1032480009982 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480009983 substrate binding site [chemical binding]; other site 1032480009984 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1032480009985 EamA-like transporter family; Region: EamA; cl01037 1032480009986 EamA-like transporter family; Region: EamA; cl01037 1032480009987 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1032480009988 Cation efflux family; Region: Cation_efflux; cl00316 1032480009989 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1032480009990 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1032480009991 Trm112p-like protein; Region: Trm112p; cl01066 1032480009992 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1032480009993 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1032480009994 active site 1032480009995 substrate binding site [chemical binding]; other site 1032480009996 metal binding site [ion binding]; metal-binding site 1032480009997 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1032480009998 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1032480009999 active site 1032480010000 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1032480010001 Transcription factor WhiB; Region: Whib; pfam02467 1032480010002 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cl00425 1032480010003 phosphate binding site [ion binding]; other site 1032480010004 dimer interface [polypeptide binding]; other site 1032480010005 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 1032480010006 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 1032480010007 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1032480010008 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1032480010009 Substrate binding site; other site 1032480010010 AMP-binding enzyme; Region: AMP-binding; cl15778 1032480010011 Protein of unknown function (DUF402); Region: DUF402; cl00979 1032480010012 Domain of unknown function (DUF385); Region: DUF385; cl04387 1032480010013 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1032480010014 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1032480010015 tetrameric interface [polypeptide binding]; other site 1032480010016 NAD binding site [chemical binding]; other site 1032480010017 catalytic residues [active] 1032480010018 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1032480010019 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1032480010020 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1032480010021 PYR/PP interface [polypeptide binding]; other site 1032480010022 dimer interface [polypeptide binding]; other site 1032480010023 TPP binding site [chemical binding]; other site 1032480010024 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1032480010025 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1032480010026 TPP-binding site; other site 1032480010027 KduI/IolB family; Region: KduI; cl01508 1032480010028 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1032480010029 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1032480010030 substrate binding site [chemical binding]; other site 1032480010031 ATP binding site [chemical binding]; other site 1032480010032 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1032480010033 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 1032480010034 Ligand binding site; other site 1032480010035 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1032480010036 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1032480010037 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1032480010038 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1032480010039 Predicted ATPase [General function prediction only]; Region: COG3910 1032480010040 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480010041 Walker A/P-loop; other site 1032480010042 ATP binding site [chemical binding]; other site 1032480010043 Q-loop/lid; other site 1032480010044 ABC transporter signature motif; other site 1032480010045 Walker B; other site 1032480010046 D-loop; other site 1032480010047 Arginase family; Region: Arginase; cl00306 1032480010048 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1032480010049 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1032480010050 active site 1032480010051 ferredoxin-NADP+ reductase; Region: PLN02852 1032480010052 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1032480010053 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 1032480010054 Protein of unknown function (DUF1255); Region: DUF1255; cl01202 1032480010055 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1032480010056 Helix-turn-helix domains; Region: HTH; cl00088 1032480010057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480010058 metabolite-proton symporter; Region: 2A0106; TIGR00883 1032480010059 putative substrate translocation pore; other site 1032480010060 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480010061 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480010062 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1032480010063 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1032480010064 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1032480010065 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480010066 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480010067 DNA binding site [nucleotide binding] 1032480010068 domain linker motif; other site 1032480010069 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480010070 dimerization interface [polypeptide binding]; other site 1032480010071 ligand binding site [chemical binding]; other site 1032480010072 Isochorismatase family; Region: Isochorismatase; pfam00857 1032480010073 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1032480010074 catalytic triad [active] 1032480010075 conserved cis-peptide bond; other site 1032480010076 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1032480010077 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 1032480010078 LssY C-terminus; Region: LssY_C; pfam14067 1032480010079 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1032480010080 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 1032480010081 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1032480010082 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1032480010083 Moco binding site; other site 1032480010084 metal coordination site [ion binding]; other site 1032480010085 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1032480010086 Histidine kinase; Region: HisKA_3; pfam07730 1032480010087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1032480010088 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480010089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480010090 active site 1032480010091 phosphorylation site [posttranslational modification] 1032480010092 intermolecular recognition site; other site 1032480010093 dimerization interface [polypeptide binding]; other site 1032480010094 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480010095 DNA binding residues [nucleotide binding] 1032480010096 dimerization interface [polypeptide binding]; other site 1032480010097 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1032480010098 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1032480010099 Walker A/P-loop; other site 1032480010100 ATP binding site [chemical binding]; other site 1032480010101 Q-loop/lid; other site 1032480010102 ABC transporter signature motif; other site 1032480010103 Walker B; other site 1032480010104 D-loop; other site 1032480010105 H-loop/switch region; other site 1032480010106 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1032480010107 FtsX-like permease family; Region: FtsX; cl15850 1032480010108 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480010109 Ligand Binding Site [chemical binding]; other site 1032480010110 CrcB-like protein; Region: CRCB; cl09114 1032480010111 CrcB-like protein; Region: CRCB; cl09114 1032480010112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480010113 putative substrate translocation pore; other site 1032480010114 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1032480010115 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480010116 Coenzyme A binding pocket [chemical binding]; other site 1032480010117 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1032480010118 OpgC protein; Region: OpgC_C; cl00792 1032480010119 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1032480010120 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1032480010121 The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators; Region: NR_LBD; cl11397 1032480010122 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480010123 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480010124 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1032480010125 NAD(P) binding site [chemical binding]; other site 1032480010126 active site 1032480010127 Phospholipid methyltransferase; Region: PEMT; cl00763 1032480010128 Cupin domain; Region: Cupin_2; cl09118 1032480010129 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1032480010130 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1032480010131 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480010132 active site 1032480010133 metal binding site [ion binding]; metal-binding site 1032480010134 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1032480010135 intersubunit interface [polypeptide binding]; other site 1032480010136 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1032480010137 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1032480010138 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1032480010139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480010140 S-adenosylmethionine binding site [chemical binding]; other site 1032480010141 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1032480010142 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480010143 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480010144 active site 1032480010145 substrate binding site [chemical binding]; other site 1032480010146 ATP binding site [chemical binding]; other site 1032480010147 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1032480010148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480010149 S-adenosylmethionine binding site [chemical binding]; other site 1032480010150 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480010151 AAA domain; Region: AAA_33; pfam13671 1032480010152 potential frameshift: common BLAST hit: gi|291301756|ref|YP_003513034.1| methyltransferase type 11 1032480010153 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1032480010154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480010155 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480010156 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480010157 active site 1032480010158 substrate binding site [chemical binding]; other site 1032480010159 ATP binding site [chemical binding]; other site 1032480010160 PemK-like protein; Region: PemK; cl00995 1032480010161 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1032480010162 conserved cys residue [active] 1032480010163 Cupin domain; Region: Cupin_2; cl09118 1032480010164 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1032480010165 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480010166 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480010167 L-idonate 5-dehydrogenase; Region: PLN02702 1032480010168 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1032480010169 inhibitor binding site; inhibition site 1032480010170 catalytic Zn binding site [ion binding]; other site 1032480010171 structural Zn binding site [ion binding]; other site 1032480010172 NADP binding site [chemical binding]; other site 1032480010173 tetramer interface [polypeptide binding]; other site 1032480010174 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1032480010175 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480010176 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480010177 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480010178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480010179 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480010180 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480010181 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 1032480010182 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480010183 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 1032480010184 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480010185 substrate binding site [chemical binding]; other site 1032480010186 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1032480010187 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480010188 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1032480010189 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480010190 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1032480010191 active site 1032480010192 catalytic motif [active] 1032480010193 Zn binding site [ion binding]; other site 1032480010194 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 1032480010195 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1032480010196 Integrase core domain; Region: rve; cl01316 1032480010197 Helix-turn-helix domains; Region: HTH; cl00088 1032480010198 HTH-like domain; Region: HTH_21; pfam13276 1032480010199 Integrase core domain; Region: rve; cl01316 1032480010200 Integrase core domain; Region: rve_3; cl15866 1032480010201 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1032480010202 Helix-turn-helix domains; Region: HTH; cl00088 1032480010203 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480010204 putative acetyltransferase; Provisional; Region: PRK03624 1032480010205 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480010206 Coenzyme A binding pocket [chemical binding]; other site 1032480010207 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 1032480010208 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1032480010209 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 1032480010210 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1032480010211 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480010212 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480010213 substrate binding site [chemical binding]; other site 1032480010214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480010215 putative transporter; Provisional; Region: PRK10504 1032480010216 putative substrate translocation pore; other site 1032480010217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480010218 Helix-turn-helix domains; Region: HTH; cl00088 1032480010219 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1032480010220 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480010221 Coenzyme A binding pocket [chemical binding]; other site 1032480010222 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1032480010223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480010224 S-adenosylmethionine binding site [chemical binding]; other site 1032480010225 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1032480010226 E3 interaction surface; other site 1032480010227 lipoyl attachment site [posttranslational modification]; other site 1032480010228 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480010229 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1032480010230 NAD(P) binding site [chemical binding]; other site 1032480010231 active site 1032480010232 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1032480010233 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480010234 Walker A motif; other site 1032480010235 ATP binding site [chemical binding]; other site 1032480010236 Walker B motif; other site 1032480010237 arginine finger; other site 1032480010238 Integrase core domain; Region: rve; cl01316 1032480010239 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480010240 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480010241 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1032480010242 metal binding triad [ion binding]; metal-binding site 1032480010243 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480010244 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1032480010245 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480010246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480010247 active site 1032480010248 phosphorylation site [posttranslational modification] 1032480010249 intermolecular recognition site; other site 1032480010250 dimerization interface [polypeptide binding]; other site 1032480010251 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480010252 DNA binding residues [nucleotide binding] 1032480010253 dimerization interface [polypeptide binding]; other site 1032480010254 Histidine kinase; Region: HisKA_3; pfam07730 1032480010255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1032480010256 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1032480010257 EamA-like transporter family; Region: EamA; cl01037 1032480010258 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1032480010259 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480010260 DNA-binding site [nucleotide binding]; DNA binding site 1032480010261 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480010262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480010263 homodimer interface [polypeptide binding]; other site 1032480010264 catalytic residue [active] 1032480010265 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480010266 Helix-turn-helix domains; Region: HTH; cl00088 1032480010267 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 1032480010268 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 1032480010269 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480010270 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480010271 active site 1032480010272 substrate binding site [chemical binding]; other site 1032480010273 ATP binding site [chemical binding]; other site 1032480010274 MatE; Region: MatE; cl10513 1032480010275 MatE; Region: MatE; cl10513 1032480010276 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480010277 Helix-turn-helix domains; Region: HTH; cl00088 1032480010278 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1032480010279 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1032480010280 intersubunit interface [polypeptide binding]; other site 1032480010281 Cupin domain; Region: Cupin_2; cl09118 1032480010282 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1032480010283 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1032480010284 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480010285 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480010286 active site 1032480010287 catalytic tetrad [active] 1032480010288 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480010289 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1032480010290 NAD(P) binding site [chemical binding]; other site 1032480010291 active site 1032480010292 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1032480010293 Helix-turn-helix domains; Region: HTH; cl00088 1032480010294 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1032480010295 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480010296 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1032480010297 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 1032480010298 metal binding site [ion binding]; metal-binding site 1032480010299 substrate binding pocket [chemical binding]; other site 1032480010300 choline dehydrogenase; Validated; Region: PRK02106 1032480010301 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1032480010302 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1032480010303 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1032480010304 NAD(P) binding site [chemical binding]; other site 1032480010305 catalytic residues [active] 1032480010306 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480010307 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1032480010308 active site 1032480010309 metal binding site [ion binding]; metal-binding site 1032480010310 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1032480010311 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480010312 Walker A motif; other site 1032480010313 ATP binding site [chemical binding]; other site 1032480010314 Walker B motif; other site 1032480010315 arginine finger; other site 1032480010316 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1032480010317 Cupin domain; Region: Cupin_2; cl09118 1032480010318 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1032480010319 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480010320 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1032480010321 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1032480010322 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1032480010323 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480010324 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480010325 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1032480010326 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480010327 Integral membrane protein TerC family; Region: TerC; cl10468 1032480010328 excinuclease ABC subunit B; Provisional; Region: PRK05298 1032480010329 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480010330 putative Mg++ binding site [ion binding]; other site 1032480010331 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480010332 nucleotide binding region [chemical binding]; other site 1032480010333 ATP-binding site [chemical binding]; other site 1032480010334 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1032480010335 UvrB/uvrC motif; Region: UVR; pfam02151 1032480010336 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1032480010337 Protease prsW family; Region: PrsW-protease; cl15823 1032480010338 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1032480010339 dephospho-CoA kinase; Region: TIGR00152 1032480010340 CoA-binding site [chemical binding]; other site 1032480010341 ATP-binding [chemical binding]; other site 1032480010342 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1032480010343 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1032480010344 RNA binding site [nucleotide binding]; other site 1032480010345 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1032480010346 RNA binding site [nucleotide binding]; other site 1032480010347 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1032480010348 RNA binding site [nucleotide binding]; other site 1032480010349 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1032480010350 RNA binding site [nucleotide binding]; other site 1032480010351 Sulfate transporter family; Region: Sulfate_transp; cl15842 1032480010352 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1032480010353 Sulfate transporter family; Region: Sulfate_transp; cl15842 1032480010354 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1032480010355 DNA polymerase I; Provisional; Region: PRK05755 1032480010356 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1032480010357 active site 1032480010358 metal binding site 1 [ion binding]; metal-binding site 1032480010359 putative 5' ssDNA interaction site; other site 1032480010360 metal binding site 3; metal-binding site 1032480010361 metal binding site 2 [ion binding]; metal-binding site 1032480010362 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1032480010363 putative DNA binding site [nucleotide binding]; other site 1032480010364 putative metal binding site [ion binding]; other site 1032480010365 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1032480010366 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1032480010367 active site 1032480010368 DNA binding site [nucleotide binding] 1032480010369 catalytic site [active] 1032480010370 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1032480010371 putative active site [active] 1032480010372 glycerol kinase; Provisional; Region: glpK; PRK00047 1032480010373 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 1032480010374 N- and C-terminal domain interface [polypeptide binding]; other site 1032480010375 putative active site [active] 1032480010376 putative MgATP binding site [chemical binding]; other site 1032480010377 catalytic site [active] 1032480010378 metal binding site [ion binding]; metal-binding site 1032480010379 putative homotetramer interface [polypeptide binding]; other site 1032480010380 putative glycerol binding site [chemical binding]; other site 1032480010381 homodimer interface [polypeptide binding]; other site 1032480010382 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 1032480010383 amphipathic channel; other site 1032480010384 Asn-Pro-Ala signature motifs; other site 1032480010385 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1032480010386 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1032480010387 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480010388 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1032480010389 allantoinase; Region: allantoinase; TIGR03178 1032480010390 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1032480010391 active site 1032480010392 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1032480010393 Sodium:solute symporter family; Region: SSF; cl00456 1032480010394 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480010395 non-specific DNA binding site [nucleotide binding]; other site 1032480010396 salt bridge; other site 1032480010397 sequence-specific DNA binding site [nucleotide binding]; other site 1032480010398 Cupin domain; Region: Cupin_2; cl09118 1032480010399 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1032480010400 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 1032480010401 Walker A/P-loop; other site 1032480010402 ATP binding site [chemical binding]; other site 1032480010403 Q-loop/lid; other site 1032480010404 ABC transporter signature motif; other site 1032480010405 Walker B; other site 1032480010406 D-loop; other site 1032480010407 H-loop/switch region; other site 1032480010408 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1032480010409 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 1032480010410 Walker A/P-loop; other site 1032480010411 ATP binding site [chemical binding]; other site 1032480010412 Q-loop/lid; other site 1032480010413 ABC transporter signature motif; other site 1032480010414 Walker B; other site 1032480010415 D-loop; other site 1032480010416 H-loop/switch region; other site 1032480010417 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1032480010418 TM-ABC transporter signature motif; other site 1032480010419 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1032480010420 TM-ABC transporter signature motif; other site 1032480010421 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1032480010422 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1032480010423 dimerization interface [polypeptide binding]; other site 1032480010424 ligand binding site [chemical binding]; other site 1032480010425 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1032480010426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480010427 active site 1032480010428 phosphorylation site [posttranslational modification] 1032480010429 intermolecular recognition site; other site 1032480010430 dimerization interface [polypeptide binding]; other site 1032480010431 ANTAR domain; Region: ANTAR; cl04297 1032480010432 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1032480010433 pyruvate kinase; Provisional; Region: PRK06247 1032480010434 domain interfaces; other site 1032480010435 active site 1032480010436 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1032480010437 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1032480010438 RNA binding surface [nucleotide binding]; other site 1032480010439 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 1032480010440 active site 1032480010441 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1032480010442 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1032480010443 DivIVA domain; Region: DivI1A_domain; TIGR03544 1032480010444 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1032480010445 V-type ATP synthase subunit E; Provisional; Region: PRK02292 1032480010446 YGGT family; Region: YGGT; cl00508 1032480010447 Protein of unknown function (DUF552); Region: DUF552; cl00775 1032480010448 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 1032480010449 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1032480010450 nucleotide binding site [chemical binding]; other site 1032480010451 SulA interaction site; other site 1032480010452 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1032480010453 Cell division protein FtsQ; Region: FtsQ; pfam03799 1032480010454 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1032480010455 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1032480010456 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1032480010457 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1032480010458 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1032480010459 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1032480010460 active site 1032480010461 homodimer interface [polypeptide binding]; other site 1032480010462 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1032480010463 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 1032480010464 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480010465 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1032480010466 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1032480010467 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1032480010468 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1032480010469 Mg++ binding site [ion binding]; other site 1032480010470 putative catalytic motif [active] 1032480010471 putative substrate binding site [chemical binding]; other site 1032480010472 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1032480010473 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1032480010474 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1032480010475 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1032480010476 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1032480010477 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1032480010478 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1032480010479 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1032480010480 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1032480010481 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1032480010482 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1032480010483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480010484 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1032480010485 cell division protein MraZ; Reviewed; Region: PRK00326 1032480010486 MraZ protein; Region: MraZ; pfam02381 1032480010487 MraZ protein; Region: MraZ; pfam02381 1032480010488 MoxR-like ATPases [General function prediction only]; Region: COG0714 1032480010489 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480010490 ATP binding site [chemical binding]; other site 1032480010491 Walker A motif; other site 1032480010492 Walker B motif; other site 1032480010493 arginine finger; other site 1032480010494 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1032480010495 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1032480010496 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 1032480010497 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1032480010498 putative active site [active] 1032480010499 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1032480010500 DNA polymerase IV; Validated; Region: PRK03858 1032480010501 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1032480010502 active site 1032480010503 DNA binding site [nucleotide binding] 1032480010504 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480010505 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1032480010506 Rdx family; Region: Rdx; cl01407 1032480010507 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1032480010508 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1032480010509 substrate binding site [chemical binding]; other site 1032480010510 ATP binding site [chemical binding]; other site 1032480010511 phytoene desaturase; Region: crtI_fam; TIGR02734 1032480010512 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1032480010513 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480010514 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1032480010515 Family description; Region: UvrD_C_2; cl15862 1032480010516 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 1032480010517 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1032480010518 FAD binding site [chemical binding]; other site 1032480010519 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1032480010520 substrate binding pocket [chemical binding]; other site 1032480010521 chain length determination region; other site 1032480010522 substrate-Mg2+ binding site; other site 1032480010523 catalytic residues [active] 1032480010524 aspartate-rich region 1; other site 1032480010525 active site lid residues [active] 1032480010526 aspartate-rich region 2; other site 1032480010527 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 1032480010528 RNAase interaction site [polypeptide binding]; other site 1032480010529 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 1032480010530 active site 1032480010531 barstar interaction site; other site 1032480010532 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1032480010533 active site 1032480010534 thiamine phosphate binding site [chemical binding]; other site 1032480010535 pyrophosphate binding site [ion binding]; other site 1032480010536 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480010537 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1032480010538 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1032480010539 thiS-thiF/thiG interaction site; other site 1032480010540 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1032480010541 ThiS interaction site; other site 1032480010542 putative active site [active] 1032480010543 tetramer interface [polypeptide binding]; other site 1032480010544 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1032480010545 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1032480010546 active site 1032480010547 ATP binding site [chemical binding]; other site 1032480010548 substrate binding site [chemical binding]; other site 1032480010549 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480010550 substrate binding site [chemical binding]; other site 1032480010551 activation loop (A-loop); other site 1032480010552 activation loop (A-loop); other site 1032480010553 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 1032480010554 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1032480010555 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1032480010556 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1032480010557 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1032480010558 EamA-like transporter family; Region: EamA; cl01037 1032480010559 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1032480010560 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1032480010561 NAD(P) binding site [chemical binding]; other site 1032480010562 putative active site [active] 1032480010563 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1032480010564 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480010565 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 1032480010566 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480010567 catalytic residue [active] 1032480010568 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 1032480010569 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1032480010570 putative acyl-acceptor binding pocket; other site 1032480010571 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1032480010572 putative acyl-acceptor binding pocket; other site 1032480010573 Esterase/lipase [General function prediction only]; Region: COG1647 1032480010574 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1032480010575 Bacterial SH3 domain; Region: SH3_3; cl02551 1032480010576 Bacterial SH3 domain; Region: SH3_3; cl02551 1032480010577 NlpC/P60 family; Region: NLPC_P60; cl11438 1032480010578 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1032480010579 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1032480010580 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1032480010581 putative hydrophobic ligand binding site [chemical binding]; other site 1032480010582 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1032480010583 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1032480010584 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1032480010585 Autophagy protein Apg6; Region: APG6; pfam04111 1032480010586 NlpC/P60 family; Region: NLPC_P60; cl11438 1032480010587 hypothetical protein; Validated; Region: PRK07883 1032480010588 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1032480010589 active site 1032480010590 substrate binding site [chemical binding]; other site 1032480010591 catalytic site [active] 1032480010592 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1032480010593 GIY-YIG motif/motif A; other site 1032480010594 active site 1032480010595 catalytic site [active] 1032480010596 putative DNA binding site [nucleotide binding]; other site 1032480010597 metal binding site [ion binding]; metal-binding site 1032480010598 Helix-turn-helix domains; Region: HTH; cl00088 1032480010599 Helix-turn-helix domains; Region: HTH; cl00088 1032480010600 intramembrane serine protease GlpG; Provisional; Region: PRK10907 1032480010601 Rhomboid family; Region: Rhomboid; cl11446 1032480010602 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 1032480010603 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1032480010604 active site 1032480010605 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1032480010606 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1032480010607 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1032480010608 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1032480010609 Response regulator receiver domain; Region: Response_reg; pfam00072 1032480010610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480010611 active site 1032480010612 phosphorylation site [posttranslational modification] 1032480010613 intermolecular recognition site; other site 1032480010614 dimerization interface [polypeptide binding]; other site 1032480010615 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 1032480010616 Cytochrome c; Region: Cytochrom_C; cl11414 1032480010617 Cytochrome c; Region: Cytochrom_C; cl11414 1032480010618 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1032480010619 iron-sulfur cluster [ion binding]; other site 1032480010620 [2Fe-2S] cluster binding site [ion binding]; other site 1032480010621 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1032480010622 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1032480010623 heme bH binding site [chemical binding]; other site 1032480010624 intrachain domain interface; other site 1032480010625 heme bL binding site [chemical binding]; other site 1032480010626 interchain domain interface [polypeptide binding]; other site 1032480010627 Qo binding site; other site 1032480010628 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1032480010629 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1032480010630 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1032480010631 putative dimer interface [polypeptide binding]; other site 1032480010632 N-terminal domain interface [polypeptide binding]; other site 1032480010633 putative substrate binding pocket (H-site) [chemical binding]; other site 1032480010634 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1032480010635 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1032480010636 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1032480010637 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 1032480010638 active site 1032480010639 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1032480010640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480010641 active site 1032480010642 phosphorylation site [posttranslational modification] 1032480010643 intermolecular recognition site; other site 1032480010644 dimerization interface [polypeptide binding]; other site 1032480010645 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1032480010646 DNA binding site [nucleotide binding] 1032480010647 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480010648 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480010649 catalytic residue [active] 1032480010650 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480010651 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1032480010652 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1032480010653 putative active site [active] 1032480010654 heme pocket [chemical binding]; other site 1032480010655 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1032480010656 dimer interface [polypeptide binding]; other site 1032480010657 phosphorylation site [posttranslational modification] 1032480010658 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480010659 ATP binding site [chemical binding]; other site 1032480010660 Mg2+ binding site [ion binding]; other site 1032480010661 G-X-G motif; other site 1032480010662 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1032480010663 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480010664 active site 1032480010665 phosphorylation site [posttranslational modification] 1032480010666 intermolecular recognition site; other site 1032480010667 dimerization interface [polypeptide binding]; other site 1032480010668 Response regulator receiver domain; Region: Response_reg; pfam00072 1032480010669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480010670 active site 1032480010671 phosphorylation site [posttranslational modification] 1032480010672 intermolecular recognition site; other site 1032480010673 dimerization interface [polypeptide binding]; other site 1032480010674 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1032480010675 Response regulator receiver domain; Region: Response_reg; pfam00072 1032480010676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480010677 active site 1032480010678 phosphorylation site [posttranslational modification] 1032480010679 intermolecular recognition site; other site 1032480010680 dimerization interface [polypeptide binding]; other site 1032480010681 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 1032480010682 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 1032480010683 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480010684 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1032480010685 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1032480010686 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1032480010687 D-pathway; other site 1032480010688 Putative ubiquinol binding site [chemical binding]; other site 1032480010689 Low-spin heme (heme b) binding site [chemical binding]; other site 1032480010690 Putative water exit pathway; other site 1032480010691 Binuclear center (heme o3/CuB) [ion binding]; other site 1032480010692 K-pathway; other site 1032480010693 Putative proton exit pathway; other site 1032480010694 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1032480010695 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1032480010696 Glycerate kinase family; Region: Gly_kinase; cl00841 1032480010697 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1032480010698 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1032480010699 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1032480010700 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480010701 active site 1032480010702 catalytic tetrad [active] 1032480010703 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1032480010704 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1032480010705 dimer interface [polypeptide binding]; other site 1032480010706 active site 1032480010707 CoA binding pocket [chemical binding]; other site 1032480010708 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1032480010709 nudix motif; other site 1032480010710 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1032480010711 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1032480010712 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1032480010713 interface (dimer of trimers) [polypeptide binding]; other site 1032480010714 Substrate-binding/catalytic site; other site 1032480010715 Zn-binding sites [ion binding]; other site 1032480010716 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 1032480010717 dimer interface [polypeptide binding]; other site 1032480010718 putative active site [active] 1032480010719 ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854 1032480010720 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1032480010721 inhibitor-cofactor binding pocket; inhibition site 1032480010722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480010723 catalytic residue [active] 1032480010724 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1032480010725 Amidinotransferase; Region: Amidinotransf; cl12043 1032480010726 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1032480010727 Helix-turn-helix domains; Region: HTH; cl00088 1032480010728 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1032480010729 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1032480010730 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1032480010731 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1032480010732 E3 interaction surface; other site 1032480010733 lipoyl attachment site [posttranslational modification]; other site 1032480010734 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1032480010735 E3 interaction surface; other site 1032480010736 lipoyl attachment site [posttranslational modification]; other site 1032480010737 e3 binding domain; Region: E3_binding; pfam02817 1032480010738 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 1032480010739 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 1032480010740 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480010741 TIGR01777 family protein; Region: yfcH 1032480010742 NAD(P) binding site [chemical binding]; other site 1032480010743 active site 1032480010744 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1032480010745 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1032480010746 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 1032480010747 Walker A/P-loop; other site 1032480010748 ATP binding site [chemical binding]; other site 1032480010749 Q-loop/lid; other site 1032480010750 ABC transporter signature motif; other site 1032480010751 Walker B; other site 1032480010752 D-loop; other site 1032480010753 H-loop/switch region; other site 1032480010754 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1032480010755 lipoyl synthase; Provisional; Region: PRK05481 1032480010756 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1032480010757 FeS/SAM binding site; other site 1032480010758 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1032480010759 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1032480010760 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1032480010761 ABC transporter; Region: ABC_tran_2; pfam12848 1032480010762 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1032480010763 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1032480010764 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480010765 NAD(P) binding site [chemical binding]; other site 1032480010766 active site 1032480010767 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480010768 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1032480010769 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480010770 Helix-turn-helix domains; Region: HTH; cl00088 1032480010771 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1032480010772 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 1032480010773 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1032480010774 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1032480010775 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480010776 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 1032480010777 FAD binding domain; Region: FAD_binding_4; pfam01565 1032480010778 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1032480010779 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 1032480010780 NHL repeat; Region: NHL; pfam01436 1032480010781 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1032480010782 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1032480010783 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1032480010784 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1032480010785 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1032480010786 RDD family; Region: RDD; cl00746 1032480010787 glutamine synthetase, type I; Region: GlnA; TIGR00653 1032480010788 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1032480010789 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1032480010790 Helix-turn-helix domains; Region: HTH; cl00088 1032480010791 putative DNA binding helix; other site 1032480010792 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1032480010793 active site 1032480010794 NTP binding site [chemical binding]; other site 1032480010795 metal binding triad [ion binding]; metal-binding site 1032480010796 antibiotic binding site [chemical binding]; other site 1032480010797 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1032480010798 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1032480010799 active site 1032480010800 metal binding site [ion binding]; metal-binding site 1032480010801 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 1032480010802 active site 1032480010803 metal binding site [ion binding]; metal-binding site 1032480010804 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 1032480010805 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480010806 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480010807 Family description; Region: UvrD_C_2; cl15862 1032480010808 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 1032480010809 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1032480010810 UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449 1032480010811 putative ADP-binding pocket [chemical binding]; other site 1032480010812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480010813 putative substrate translocation pore; other site 1032480010814 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1032480010815 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1032480010816 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1032480010817 metal binding triad; other site 1032480010818 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1032480010819 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1032480010820 metal binding triad; other site 1032480010821 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1032480010822 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1032480010823 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1032480010824 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1032480010825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480010826 putative substrate translocation pore; other site 1032480010827 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1032480010828 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1032480010829 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1032480010830 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1032480010831 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1032480010832 metal binding site 2 [ion binding]; metal-binding site 1032480010833 putative DNA binding helix; other site 1032480010834 metal binding site 1 [ion binding]; metal-binding site 1032480010835 dimer interface [polypeptide binding]; other site 1032480010836 structural Zn2+ binding site [ion binding]; other site 1032480010837 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1032480010838 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1032480010839 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1032480010840 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1032480010841 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 1032480010842 putative transposase OrfB; Reviewed; Region: PHA02517 1032480010843 HTH-like domain; Region: HTH_21; pfam13276 1032480010844 Integrase core domain; Region: rve; cl01316 1032480010845 Integrase core domain; Region: rve_3; cl15866 1032480010846 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1032480010847 active site 1032480010848 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1032480010849 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 1032480010850 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480010851 Helix-turn-helix domains; Region: HTH; cl00088 1032480010852 Integrase core domain; Region: rve; cl01316 1032480010853 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1032480010854 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480010855 Walker A motif; other site 1032480010856 ATP binding site [chemical binding]; other site 1032480010857 Walker B motif; other site 1032480010858 arginine finger; other site 1032480010859 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1032480010860 putative catalytic site [active] 1032480010861 putative metal binding site [ion binding]; other site 1032480010862 putative phosphate binding site [ion binding]; other site 1032480010863 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 1032480010864 RNB domain; Region: RNB; pfam00773 1032480010865 ribonuclease R; Region: RNase_R; TIGR02063 1032480010866 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1032480010867 Putative zinc ribbon domain; Region: DUF164; pfam02591 1032480010868 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1032480010869 catalytic core [active] 1032480010870 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 1032480010871 proline aminopeptidase P II; Provisional; Region: PRK10879 1032480010872 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1032480010873 active site 1032480010874 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 1032480010875 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 1032480010876 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1032480010877 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 1032480010878 Predicted ATPase [General function prediction only]; Region: COG3899 1032480010879 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480010880 DNA binding residues [nucleotide binding] 1032480010881 dimerization interface [polypeptide binding]; other site 1032480010882 Family description; Region: VCBS; pfam13517 1032480010883 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1032480010884 MgtE intracellular N domain; Region: MgtE_N; cl15244 1032480010885 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1032480010886 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 1032480010887 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 1032480010888 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such...; Region: APH_ChoK_like_1; cd05155 1032480010889 putative active site [active] 1032480010890 putative substrate binding site [chemical binding]; other site 1032480010891 ATP binding site [chemical binding]; other site 1032480010892 Domain of unknown function DUF59; Region: DUF59; cl00941 1032480010893 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1032480010894 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1032480010895 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1032480010896 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1032480010897 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1032480010898 Putative zinc-finger; Region: zf-HC2; cl15806 1032480010899 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1032480010900 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480010901 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1032480010902 DNA binding residues [nucleotide binding] 1032480010903 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1032480010904 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1032480010905 dimer interface [polypeptide binding]; other site 1032480010906 active site 1032480010907 catalytic residue [active] 1032480010908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480010909 S-adenosylmethionine binding site [chemical binding]; other site 1032480010910 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1032480010911 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1032480010912 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1032480010913 ligand binding site; other site 1032480010914 oligomer interface; other site 1032480010915 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1032480010916 dimer interface [polypeptide binding]; other site 1032480010917 N-terminal domain interface [polypeptide binding]; other site 1032480010918 sulfate 1 binding site; other site 1032480010919 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1032480010920 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1032480010921 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1032480010922 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1032480010923 putative deacylase active site [active] 1032480010924 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1032480010925 enoyl-CoA hydratase; Provisional; Region: PRK06688 1032480010926 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1032480010927 substrate binding site [chemical binding]; other site 1032480010928 oxyanion hole (OAH) forming residues; other site 1032480010929 trimer interface [polypeptide binding]; other site 1032480010930 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1032480010931 DivIVA domain; Region: DivI1A_domain; TIGR03544 1032480010932 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1032480010933 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 1032480010934 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1032480010935 metal binding site [ion binding]; metal-binding site 1032480010936 putative dimer interface [polypeptide binding]; other site 1032480010937 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1032480010938 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1032480010939 putative trimer interface [polypeptide binding]; other site 1032480010940 putative CoA binding site [chemical binding]; other site 1032480010941 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480010942 NAD(P) binding site [chemical binding]; other site 1032480010943 active site 1032480010944 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1032480010945 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1032480010946 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1032480010947 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1032480010948 metal-binding site [ion binding] 1032480010949 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1032480010950 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1032480010951 metal-binding site [ion binding] 1032480010952 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1032480010953 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1032480010954 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1032480010955 Cation efflux family; Region: Cation_efflux; cl00316 1032480010956 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480010957 dimerization interface [polypeptide binding]; other site 1032480010958 putative DNA binding site [nucleotide binding]; other site 1032480010959 putative Zn2+ binding site [ion binding]; other site 1032480010960 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480010961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480010962 active site 1032480010963 phosphorylation site [posttranslational modification] 1032480010964 intermolecular recognition site; other site 1032480010965 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480010966 DNA binding residues [nucleotide binding] 1032480010967 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1032480010968 Histidine kinase; Region: HisKA_3; pfam07730 1032480010969 succinyldiaminopimelate transaminase; Region: DapC_actino; TIGR03539 1032480010970 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480010971 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480010972 homodimer interface [polypeptide binding]; other site 1032480010973 catalytic residue [active] 1032480010974 Ferredoxin [Energy production and conversion]; Region: COG1146 1032480010975 4Fe-4S binding domain; Region: Fer4; cl02805 1032480010976 Predicted acetyltransferase [General function prediction only]; Region: COG3153 1032480010977 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480010978 Coenzyme A binding pocket [chemical binding]; other site 1032480010979 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1032480010980 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1032480010981 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1032480010982 VanW like protein; Region: VanW; pfam04294 1032480010983 Flavin Reductases; Region: FlaRed; cl00801 1032480010984 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1032480010985 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1032480010986 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1032480010987 Walker A/P-loop; other site 1032480010988 ATP binding site [chemical binding]; other site 1032480010989 Q-loop/lid; other site 1032480010990 ABC transporter signature motif; other site 1032480010991 Walker B; other site 1032480010992 D-loop; other site 1032480010993 H-loop/switch region; other site 1032480010994 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1032480010995 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1032480010996 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1032480010997 Walker A/P-loop; other site 1032480010998 ATP binding site [chemical binding]; other site 1032480010999 Q-loop/lid; other site 1032480011000 ABC transporter signature motif; other site 1032480011001 Walker B; other site 1032480011002 D-loop; other site 1032480011003 H-loop/switch region; other site 1032480011004 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1032480011005 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1032480011006 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1032480011007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480011008 dimer interface [polypeptide binding]; other site 1032480011009 conserved gate region; other site 1032480011010 putative PBP binding loops; other site 1032480011011 ABC-ATPase subunit interface; other site 1032480011012 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1032480011013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480011014 dimer interface [polypeptide binding]; other site 1032480011015 conserved gate region; other site 1032480011016 putative PBP binding loops; other site 1032480011017 ABC-ATPase subunit interface; other site 1032480011018 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1032480011019 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1032480011020 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480011021 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 1032480011022 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 1032480011023 substrate binding site [chemical binding]; other site 1032480011024 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1032480011025 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1032480011026 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480011027 Walker A/P-loop; other site 1032480011028 ATP binding site [chemical binding]; other site 1032480011029 Q-loop/lid; other site 1032480011030 ABC transporter signature motif; other site 1032480011031 Walker B; other site 1032480011032 D-loop; other site 1032480011033 H-loop/switch region; other site 1032480011034 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1032480011035 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 1032480011036 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 1032480011037 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1032480011038 putative ADP-binding pocket [chemical binding]; other site 1032480011039 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 1032480011040 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1032480011041 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 1032480011042 YCII-related domain; Region: YCII; cl00999 1032480011043 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1032480011044 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480011045 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480011046 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1032480011047 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1032480011048 Zn binding site [ion binding]; other site 1032480011049 short chain dehydrogenase; Validated; Region: PRK05855 1032480011050 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480011051 Bacterial Ig-like domain; Region: Big_5; cl01012 1032480011052 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1032480011053 Protein of unknown function (DUF328); Region: DUF328; cl01143 1032480011054 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1032480011055 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 1032480011056 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1032480011057 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480011058 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480011059 Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172 1032480011060 PLD-like domain; Region: PLDc_2; pfam13091 1032480011061 putative active site [active] 1032480011062 catalytic site [active] 1032480011063 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 1032480011064 putative active site [active] 1032480011065 catalytic site [active] 1032480011066 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1032480011067 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1032480011068 putative active site [active] 1032480011069 GTP-binding protein YchF; Reviewed; Region: PRK09601 1032480011070 YchF GTPase; Region: YchF; cd01900 1032480011071 G1 box; other site 1032480011072 GTP/Mg2+ binding site [chemical binding]; other site 1032480011073 Switch I region; other site 1032480011074 G2 box; other site 1032480011075 Switch II region; other site 1032480011076 G3 box; other site 1032480011077 G4 box; other site 1032480011078 G5 box; other site 1032480011079 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1032480011080 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1032480011081 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1032480011082 active site 1032480011083 metal binding site [ion binding]; metal-binding site 1032480011084 RmuC family; Region: RmuC; pfam02646 1032480011085 Fibronectin type III-like domain; Region: Fn3-like; cl15273 1032480011086 LytB protein; Region: LYTB; cl00507 1032480011087 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 1032480011088 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1032480011089 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1032480011090 generic binding surface II; other site 1032480011091 generic binding surface I; other site 1032480011092 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 1032480011093 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1032480011094 conserved cys residue [active] 1032480011095 Helix-turn-helix domain; Region: HTH_18; pfam12833 1032480011096 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480011097 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1032480011098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 1032480011099 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1032480011100 Class II fumarases; Region: Fumarase_classII; cd01362 1032480011101 active site 1032480011102 tetramer interface [polypeptide binding]; other site 1032480011103 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1032480011104 putative active site [active] 1032480011105 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1032480011106 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1032480011107 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1032480011108 putative active site [active] 1032480011109 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480011110 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1032480011111 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1032480011112 catalytic residue [active] 1032480011113 putative FPP diphosphate binding site; other site 1032480011114 putative FPP binding hydrophobic cleft; other site 1032480011115 dimer interface [polypeptide binding]; other site 1032480011116 putative IPP diphosphate binding site; other site 1032480011117 Haemolysin-III related; Region: HlyIII; cl03831 1032480011118 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1032480011119 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1032480011120 catalytic residues [active] 1032480011121 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1032480011122 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1032480011123 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1032480011124 Fic family protein [Function unknown]; Region: COG3177 1032480011125 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 1032480011126 Fic/DOC family; Region: Fic; cl00960 1032480011127 Helix-turn-helix domains; Region: HTH; cl00088 1032480011128 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480011129 dimerization interface [polypeptide binding]; other site 1032480011130 putative DNA binding site [nucleotide binding]; other site 1032480011131 putative Zn2+ binding site [ion binding]; other site 1032480011132 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1032480011133 hydrophobic ligand binding site; other site 1032480011134 YCII-related domain; Region: YCII; cl00999 1032480011135 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1032480011136 siderophore binding site; other site 1032480011137 Protein of unknown function (DUF419); Region: DUF419; cl15265 1032480011138 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1032480011139 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1032480011140 Walker A/P-loop; other site 1032480011141 ATP binding site [chemical binding]; other site 1032480011142 Q-loop/lid; other site 1032480011143 ABC transporter signature motif; other site 1032480011144 Walker B; other site 1032480011145 D-loop; other site 1032480011146 H-loop/switch region; other site 1032480011147 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1032480011148 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1032480011149 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1032480011150 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1032480011151 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1032480011152 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 1032480011153 Helix-turn-helix domains; Region: HTH; cl00088 1032480011154 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1032480011155 Helix-turn-helix domains; Region: HTH; cl00088 1032480011156 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480011157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480011158 putative substrate translocation pore; other site 1032480011159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480011160 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 1032480011161 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1032480011162 Helix-turn-helix domains; Region: HTH; cl00088 1032480011163 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480011164 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1032480011165 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480011166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 1032480011167 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1032480011168 ligand binding site [chemical binding]; other site 1032480011169 active site 1032480011170 UGI interface [polypeptide binding]; other site 1032480011171 catalytic site [active] 1032480011172 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1032480011173 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1032480011174 heme-binding site [chemical binding]; other site 1032480011175 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1032480011176 FAD binding pocket [chemical binding]; other site 1032480011177 FAD binding motif [chemical binding]; other site 1032480011178 phosphate binding motif [ion binding]; other site 1032480011179 beta-alpha-beta structure motif; other site 1032480011180 NAD binding pocket [chemical binding]; other site 1032480011181 Heme binding pocket [chemical binding]; other site 1032480011182 cystathionine gamma-synthase; Provisional; Region: PRK07811 1032480011183 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1032480011184 homodimer interface [polypeptide binding]; other site 1032480011185 substrate-cofactor binding pocket; other site 1032480011186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480011187 catalytic residue [active] 1032480011188 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1032480011189 active site 1032480011190 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1032480011191 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1032480011192 inhibitor-cofactor binding pocket; inhibition site 1032480011193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480011194 catalytic residue [active] 1032480011195 Bacterial sugar transferase; Region: Bac_transf; cl00939 1032480011196 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1032480011197 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1032480011198 putative trimer interface [polypeptide binding]; other site 1032480011199 putative CoA binding site [chemical binding]; other site 1032480011200 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1032480011201 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1032480011202 potential frameshift: common BLAST hit: gi|262204503|ref|YP_003275711.1| ISRSO5-transposase 1032480011203 Winged helix-turn helix; Region: HTH_29; pfam13551 1032480011204 Helix-turn-helix domains; Region: HTH; cl00088 1032480011205 Helix-turn-helix domains; Region: HTH; cl00088 1032480011206 Integrase core domain; Region: rve; cl01316 1032480011207 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480011208 DNA-binding site [nucleotide binding]; DNA binding site 1032480011209 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 1032480011210 Winged helix-turn helix; Region: HTH_29; pfam13551 1032480011211 Helix-turn-helix domains; Region: HTH; cl00088 1032480011212 Helix-turn-helix domains; Region: HTH; cl00088 1032480011213 Integrase core domain; Region: rve; cl01316 1032480011214 Integrase core domain; Region: rve_3; cl15866 1032480011215 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1032480011216 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1032480011217 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1032480011218 catalytic residues [active] 1032480011219 catalytic nucleophile [active] 1032480011220 Presynaptic Site I dimer interface [polypeptide binding]; other site 1032480011221 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1032480011222 Synaptic Flat tetramer interface [polypeptide binding]; other site 1032480011223 Synaptic Site I dimer interface [polypeptide binding]; other site 1032480011224 DNA binding site [nucleotide binding] 1032480011225 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480011226 Helix-turn-helix domains; Region: HTH; cl00088 1032480011227 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 1032480011228 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1032480011229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480011230 putative substrate translocation pore; other site 1032480011231 TIGR03987 family protein; Region: TIGR03987 1032480011232 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 1032480011233 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1032480011234 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 1032480011235 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1032480011236 Cysteine-rich domain; Region: CCG; pfam02754 1032480011237 Cysteine-rich domain; Region: CCG; pfam02754 1032480011238 L-lactate permease; Region: Lactate_perm; cl00701 1032480011239 L-lactate permease; Region: Lactate_perm; cl00701 1032480011240 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1032480011241 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480011242 DNA-binding site [nucleotide binding]; DNA binding site 1032480011243 FCD domain; Region: FCD; cl11656 1032480011244 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1032480011245 active site 1032480011246 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1032480011247 O-Antigen ligase; Region: Wzy_C; cl04850 1032480011248 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1032480011249 potential frameshift: common BLAST hit: gi|317125766|ref|YP_004099878.1| polysaccharide biosynthesis protein CapD 1032480011250 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1032480011251 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 1032480011252 NAD(P) binding site [chemical binding]; other site 1032480011253 homodimer interface [polypeptide binding]; other site 1032480011254 substrate binding site [chemical binding]; other site 1032480011255 active site 1032480011256 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480011257 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1032480011258 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 1032480011259 Ion channel; Region: Ion_trans_2; cl11596 1032480011260 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480011261 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1032480011262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480011263 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 1032480011264 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1032480011265 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1032480011266 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1032480011267 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1032480011268 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480011269 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480011270 S-adenosylmethionine binding site [chemical binding]; other site 1032480011271 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 1032480011272 nudix motif; other site 1032480011273 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1032480011274 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1032480011275 dimer interface [polypeptide binding]; other site 1032480011276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480011277 catalytic residue [active] 1032480011278 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1032480011279 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 1032480011280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480011281 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1032480011282 hydrophobic ligand binding site; other site 1032480011283 Helix-turn-helix domains; Region: HTH; cl00088 1032480011284 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1032480011285 Helix-turn-helix domains; Region: HTH; cl00088 1032480011286 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 1032480011287 DoxX; Region: DoxX; cl00976 1032480011288 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1032480011289 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1032480011290 hypothetical protein; Provisional; Region: PRK06815 1032480011291 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1032480011292 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480011293 catalytic residue [active] 1032480011294 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1032480011295 substrate binding site [chemical binding]; other site 1032480011296 ATP binding site [chemical binding]; other site 1032480011297 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1032480011298 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1032480011299 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1032480011300 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1032480011301 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1032480011302 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480011303 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480011304 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1032480011305 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cl00234 1032480011306 transcriptional regulator FimZ; Provisional; Region: PRK09935 1032480011307 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480011308 DNA binding residues [nucleotide binding] 1032480011309 dimerization interface [polypeptide binding]; other site 1032480011310 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 1032480011311 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1032480011312 putative active site [active] 1032480011313 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 1032480011314 Protein of unknown function (DUF501); Region: DUF501; cl00652 1032480011315 Septum formation initiator; Region: DivIC; cl11433 1032480011316 enolase; Provisional; Region: eno; PRK00077 1032480011317 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1032480011318 dimer interface [polypeptide binding]; other site 1032480011319 metal binding site [ion binding]; metal-binding site 1032480011320 substrate binding pocket [chemical binding]; other site 1032480011321 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 1032480011322 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 1032480011323 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1032480011324 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1032480011325 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480011326 ATP binding site [chemical binding]; other site 1032480011327 putative Mg++ binding site [ion binding]; other site 1032480011328 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480011329 nucleotide binding region [chemical binding]; other site 1032480011330 ATP-binding site [chemical binding]; other site 1032480011331 TRCF domain; Region: TRCF; cl04088 1032480011332 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1032480011333 putative active site [active] 1032480011334 catalytic residue [active] 1032480011335 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1032480011336 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1032480011337 5S rRNA interface [nucleotide binding]; other site 1032480011338 CTC domain interface [polypeptide binding]; other site 1032480011339 L16 interface [polypeptide binding]; other site 1032480011340 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1032480011341 oligomeric interface; other site 1032480011342 putative active site [active] 1032480011343 homodimer interface [polypeptide binding]; other site 1032480011344 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 1032480011345 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480011346 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480011347 active site 1032480011348 phosphorylation site [posttranslational modification] 1032480011349 intermolecular recognition site; other site 1032480011350 dimerization interface [polypeptide binding]; other site 1032480011351 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480011352 DNA binding residues [nucleotide binding] 1032480011353 dimerization interface [polypeptide binding]; other site 1032480011354 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1032480011355 Histidine kinase; Region: HisKA_3; pfam07730 1032480011356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1032480011357 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1032480011358 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1032480011359 transmembrane helices; other site 1032480011360 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1032480011361 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1032480011362 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480011363 NAD(P) binding site [chemical binding]; other site 1032480011364 active site 1032480011365 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1032480011366 FAD binding domain; Region: FAD_binding_4; pfam01565 1032480011367 Berberine and berberine like; Region: BBE; pfam08031 1032480011368 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1032480011369 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1032480011370 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1032480011371 active site 1032480011372 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1032480011373 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1032480011374 Substrate binding site; other site 1032480011375 Mg++ binding site; other site 1032480011376 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1032480011377 active site 1032480011378 substrate binding site [chemical binding]; other site 1032480011379 CoA binding site [chemical binding]; other site 1032480011380 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480011381 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480011382 active site 1032480011383 phosphorylation site [posttranslational modification] 1032480011384 intermolecular recognition site; other site 1032480011385 dimerization interface [polypeptide binding]; other site 1032480011386 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480011387 DNA binding residues [nucleotide binding] 1032480011388 dimerization interface [polypeptide binding]; other site 1032480011389 Putative sensor; Region: Sensor; pfam13796 1032480011390 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1032480011391 Histidine kinase; Region: HisKA_3; pfam07730 1032480011392 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480011393 Helix-turn-helix domains; Region: HTH; cl00088 1032480011394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480011395 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480011396 putative substrate translocation pore; other site 1032480011397 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1032480011398 Helix-turn-helix domains; Region: HTH; cl00088 1032480011399 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1032480011400 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1032480011401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480011402 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1032480011403 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1032480011404 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1032480011405 G5 domain; Region: G5; pfam07501 1032480011406 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1032480011407 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1032480011408 putative FMN binding site [chemical binding]; other site 1032480011409 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1032480011410 active site 1032480011411 Predicted methyltransferases [General function prediction only]; Region: COG0313 1032480011412 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 1032480011413 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 1032480011414 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1032480011415 potassium/proton antiporter; Reviewed; Region: PRK05326 1032480011416 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480011417 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480011418 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1032480011419 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1032480011420 A new structural DNA glycosylase; Region: AlkD_like; cl11434 1032480011421 active site 1032480011422 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1032480011423 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480011424 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480011425 dimerization interface [polypeptide binding]; other site 1032480011426 putative DNA binding site [nucleotide binding]; other site 1032480011427 Predicted transcriptional regulator [Transcription]; Region: COG2345 1032480011428 putative Zn2+ binding site [ion binding]; other site 1032480011429 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 1032480011430 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1032480011431 Transposase domain (DUF772); Region: DUF772; cl15789 1032480011432 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1032480011433 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1032480011434 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1032480011435 putative hydrophobic ligand binding site [chemical binding]; other site 1032480011436 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480011437 putative DNA binding site [nucleotide binding]; other site 1032480011438 putative Zn2+ binding site [ion binding]; other site 1032480011439 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 1032480011440 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 1032480011441 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 1032480011442 active site 1032480011443 ATP binding site [chemical binding]; other site 1032480011444 substrate binding site [chemical binding]; other site 1032480011445 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 1032480011446 active site 1032480011447 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 1032480011448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 1032480011449 Flavin Reductases; Region: FlaRed; cl00801 1032480011450 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1032480011451 metabolite-proton symporter; Region: 2A0106; TIGR00883 1032480011452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480011453 putative substrate translocation pore; other site 1032480011454 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1032480011455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480011456 dimer interface [polypeptide binding]; other site 1032480011457 conserved gate region; other site 1032480011458 putative PBP binding loops; other site 1032480011459 ABC-ATPase subunit interface; other site 1032480011460 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1032480011461 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 1032480011462 substrate binding pocket [chemical binding]; other site 1032480011463 membrane-bound complex binding site; other site 1032480011464 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1032480011465 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 1032480011466 Walker A/P-loop; other site 1032480011467 ATP binding site [chemical binding]; other site 1032480011468 Q-loop/lid; other site 1032480011469 ABC transporter signature motif; other site 1032480011470 Walker B; other site 1032480011471 D-loop; other site 1032480011472 H-loop/switch region; other site 1032480011473 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1032480011474 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1032480011475 active site 1032480011476 dimer interface [polypeptide binding]; other site 1032480011477 non-prolyl cis peptide bond; other site 1032480011478 insertion regions; other site 1032480011479 Helix-turn-helix domains; Region: HTH; cl00088 1032480011480 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1032480011481 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 1032480011482 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 1032480011483 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1032480011484 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1032480011485 Helix-turn-helix domains; Region: HTH; cl00088 1032480011486 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480011487 Walker B; other site 1032480011488 D-loop; other site 1032480011489 Helix-turn-helix domains; Region: HTH; cl00088 1032480011490 SCP-2 sterol transfer family; Region: SCP2; cl01225 1032480011491 H+ Antiporter protein; Region: 2A0121; TIGR00900 1032480011492 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1032480011493 Helix-turn-helix domains; Region: HTH; cl00088 1032480011494 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480011495 active site 1032480011496 Helix-turn-helix domains; Region: HTH; cl00088 1032480011497 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1032480011498 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1032480011499 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 1032480011500 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1032480011501 catalytic residues [active] 1032480011502 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480011503 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1032480011504 CoenzymeA binding site [chemical binding]; other site 1032480011505 subunit interaction site [polypeptide binding]; other site 1032480011506 PHB binding site; other site 1032480011507 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1032480011508 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480011509 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1032480011510 MPT binding site; other site 1032480011511 trimer interface [polypeptide binding]; other site 1032480011512 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1032480011513 trimer interface [polypeptide binding]; other site 1032480011514 dimer interface [polypeptide binding]; other site 1032480011515 putative active site [active] 1032480011516 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1032480011517 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1032480011518 dimer interface [polypeptide binding]; other site 1032480011519 putative functional site; other site 1032480011520 putative MPT binding site; other site 1032480011521 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1032480011522 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1032480011523 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1032480011524 DNA binding residues [nucleotide binding] 1032480011525 dimer interface [polypeptide binding]; other site 1032480011526 H+ Antiporter protein; Region: 2A0121; TIGR00900 1032480011527 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 1032480011528 Acylphosphatase; Region: Acylphosphatase; cl00551 1032480011529 malate synthase A; Region: malate_syn_A; TIGR01344 1032480011530 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1032480011531 active site 1032480011532 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 1032480011533 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1032480011534 tetramer interface [polypeptide binding]; other site 1032480011535 active site 1032480011536 Mg2+/Mn2+ binding site [ion binding]; other site 1032480011537 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480011538 non-specific DNA binding site [nucleotide binding]; other site 1032480011539 salt bridge; other site 1032480011540 sequence-specific DNA binding site [nucleotide binding]; other site 1032480011541 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1032480011542 Domain of unknown function (DUF955); Region: DUF955; cl01076 1032480011543 hypothetical protein; Provisional; Region: PHA03154 1032480011544 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1032480011545 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480011546 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1032480011547 Protein of unknown function DUF45; Region: DUF45; cl00636 1032480011548 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 1032480011549 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1032480011550 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480011551 ATP binding site [chemical binding]; other site 1032480011552 putative Mg++ binding site [ion binding]; other site 1032480011553 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1032480011554 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1032480011555 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1032480011556 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1032480011557 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1032480011558 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480011559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 1032480011560 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1032480011561 Helix-turn-helix domains; Region: HTH; cl00088 1032480011562 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1032480011563 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1032480011564 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1032480011565 active site 1032480011566 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1032480011567 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1032480011568 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480011569 SAF domain; Region: SAF; cl00555 1032480011570 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1032480011571 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 1032480011572 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 1032480011573 Eukaryotic UGPase catalyses the synthesis of UDP-Glucose; Region: UGPase_euk; cd00897 1032480011574 active site 1032480011575 substrate binding site; other site 1032480011576 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1032480011577 Domain of unknown function (DUF305); Region: DUF305; cl15795 1032480011578 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1032480011579 catalytic residues [active] 1032480011580 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1032480011581 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480011582 S-adenosylmethionine binding site [chemical binding]; other site 1032480011583 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1032480011584 Helix-turn-helix domains; Region: HTH; cl00088 1032480011585 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1032480011586 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1032480011587 hypothetical protein; Provisional; Region: PRK08185 1032480011588 intersubunit interface [polypeptide binding]; other site 1032480011589 active site 1032480011590 zinc binding site [ion binding]; other site 1032480011591 Na+ binding site [ion binding]; other site 1032480011592 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1032480011593 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1032480011594 active site 1032480011595 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1032480011596 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1032480011597 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1032480011598 dimer interface [polypeptide binding]; other site 1032480011599 active site 1032480011600 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1032480011601 dimer interface [polypeptide binding]; other site 1032480011602 active site 1032480011603 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1032480011604 Helix-turn-helix domains; Region: HTH; cl00088 1032480011605 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1032480011606 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 1032480011607 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1032480011608 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1032480011609 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480011610 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480011611 catalytic residue [active] 1032480011612 pyruvate carboxylase; Reviewed; Region: PRK12999 1032480011613 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1032480011614 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1032480011615 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1032480011616 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1032480011617 active site 1032480011618 catalytic residues [active] 1032480011619 metal binding site [ion binding]; metal-binding site 1032480011620 homodimer binding site [polypeptide binding]; other site 1032480011621 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1032480011622 carboxyltransferase (CT) interaction site; other site 1032480011623 biotinylation site [posttranslational modification]; other site 1032480011624 Protein of unknown function (DUF541); Region: SIMPL; cl01077 1032480011625 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480011626 H+ Antiporter protein; Region: 2A0121; TIGR00900 1032480011627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480011628 putative substrate translocation pore; other site 1032480011629 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1032480011630 Helix-turn-helix domains; Region: HTH; cl00088 1032480011631 Helix-turn-helix domains; Region: HTH; cl00088 1032480011632 Helix-turn-helix domains; Region: HTH; cl00088 1032480011633 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1032480011634 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 1032480011635 Copper resistance protein D; Region: CopD; cl00563 1032480011636 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 1032480011637 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1032480011638 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1032480011639 DNA-binding site [nucleotide binding]; DNA binding site 1032480011640 RNA-binding motif; other site 1032480011641 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1032480011642 Helix-turn-helix domains; Region: HTH; cl00088 1032480011643 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480011644 dimerization interface [polypeptide binding]; other site 1032480011645 Transmembrane secretion effector; Region: MFS_3; pfam05977 1032480011646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480011647 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1032480011648 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1032480011649 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1032480011650 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480011651 ATP binding site [chemical binding]; other site 1032480011652 putative Mg++ binding site [ion binding]; other site 1032480011653 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480011654 nucleotide binding region [chemical binding]; other site 1032480011655 ATP-binding site [chemical binding]; other site 1032480011656 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480011657 Ligand Binding Site [chemical binding]; other site 1032480011658 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480011659 Ligand Binding Site [chemical binding]; other site 1032480011660 Predicted acyl esterases [General function prediction only]; Region: COG2936 1032480011661 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 1032480011662 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1032480011663 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1032480011664 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1032480011665 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1032480011666 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1032480011667 Walker A/P-loop; other site 1032480011668 ATP binding site [chemical binding]; other site 1032480011669 Q-loop/lid; other site 1032480011670 ABC transporter signature motif; other site 1032480011671 Walker B; other site 1032480011672 D-loop; other site 1032480011673 H-loop/switch region; other site 1032480011674 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1032480011675 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 1032480011676 FtsX-like permease family; Region: FtsX; cl15850 1032480011677 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1032480011678 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1032480011679 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480011680 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480011681 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 1032480011682 putative metal binding residues [ion binding]; other site 1032480011683 signature motif; other site 1032480011684 dimer interface [polypeptide binding]; other site 1032480011685 polyP binding site; other site 1032480011686 active site 1032480011687 substrate binding site [chemical binding]; other site 1032480011688 acceptor-phosphate pocket; other site 1032480011689 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 1032480011690 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 1032480011691 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 1032480011692 nudix motif; other site 1032480011693 Helix-turn-helix domains; Region: HTH; cl00088 1032480011694 WHG domain; Region: WHG; pfam13305 1032480011695 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1032480011696 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480011697 Family description; Region: UvrD_C_2; cl15862 1032480011698 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1032480011699 dimer interface [polypeptide binding]; other site 1032480011700 catalytic triad [active] 1032480011701 CutC family; Region: CutC; cl01218 1032480011702 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1032480011703 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480011704 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480011705 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 1032480011706 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480011707 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1032480011708 active site 1032480011709 dimer interface [polypeptide binding]; other site 1032480011710 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1032480011711 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1032480011712 [4Fe-4S] binding site [ion binding]; other site 1032480011713 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1032480011714 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1032480011715 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1032480011716 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1032480011717 molybdopterin cofactor binding site; other site 1032480011718 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1032480011719 4Fe-4S binding domain; Region: Fer4; cl02805 1032480011720 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1032480011721 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 1032480011722 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 1032480011723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480011724 putative substrate translocation pore; other site 1032480011725 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1032480011726 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1032480011727 transmembrane helices; other site 1032480011728 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1032480011729 nudix motif; other site 1032480011730 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1032480011731 Quinolinate synthetase A protein; Region: NadA; cl00420 1032480011732 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 1032480011733 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480011734 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1032480011735 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 1032480011736 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1032480011737 dimerization interface [polypeptide binding]; other site 1032480011738 active site 1032480011739 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480011740 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 1032480011741 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480011742 catalytic residue [active] 1032480011743 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1032480011744 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480011745 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480011746 DNA binding residues [nucleotide binding] 1032480011747 dimerization interface [polypeptide binding]; other site 1032480011748 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1032480011749 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1032480011750 ring oligomerisation interface [polypeptide binding]; other site 1032480011751 ATP/Mg binding site [chemical binding]; other site 1032480011752 stacking interactions; other site 1032480011753 hinge regions; other site 1032480011754 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1032480011755 homodimer interface [polypeptide binding]; other site 1032480011756 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1032480011757 active site pocket [active] 1032480011758 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1032480011759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480011760 putative substrate translocation pore; other site 1032480011761 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 1032480011762 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1032480011763 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1032480011764 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1032480011765 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480011766 UMP phosphatase; Provisional; Region: PRK10444 1032480011767 active site 1032480011768 motif I; other site 1032480011769 motif II; other site 1032480011770 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480011771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1032480011772 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480011773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 1032480011774 active site 1032480011775 phosphorylation site [posttranslational modification] 1032480011776 intermolecular recognition site; other site 1032480011777 dimerization interface [polypeptide binding]; other site 1032480011778 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480011779 DNA binding residues [nucleotide binding] 1032480011780 dimerization interface [polypeptide binding]; other site 1032480011781 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480011782 ATP binding site [chemical binding]; other site 1032480011783 putative Mg++ binding site [ion binding]; other site 1032480011784 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480011785 nucleotide binding region [chemical binding]; other site 1032480011786 ATP-binding site [chemical binding]; other site 1032480011787 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1032480011788 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 1032480011789 NAD binding site [chemical binding]; other site 1032480011790 substrate binding site [chemical binding]; other site 1032480011791 catalytic Zn binding site [ion binding]; other site 1032480011792 structural Zn binding site [ion binding]; other site 1032480011793 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1032480011794 MoaE interaction surface [polypeptide binding]; other site 1032480011795 MoeB interaction surface [polypeptide binding]; other site 1032480011796 thiocarboxylated glycine; other site 1032480011797 threonine synthase; Validated; Region: PRK07591 1032480011798 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1032480011799 homodimer interface [polypeptide binding]; other site 1032480011800 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480011801 catalytic residue [active] 1032480011802 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1032480011803 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480011804 Walker A motif; other site 1032480011805 ATP binding site [chemical binding]; other site 1032480011806 Walker B motif; other site 1032480011807 arginine finger; other site 1032480011808 Integrase core domain; Region: rve; cl01316 1032480011809 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1032480011810 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480011811 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1032480011812 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480011813 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480011814 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1032480011815 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 1032480011816 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480011817 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480011818 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1032480011819 hypothetical protein; Provisional; Region: PRK11770 1032480011820 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1032480011821 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1032480011822 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 1032480011823 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1032480011824 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 1032480011825 Walker A/P-loop; other site 1032480011826 ATP binding site [chemical binding]; other site 1032480011827 Q-loop/lid; other site 1032480011828 ABC transporter signature motif; other site 1032480011829 Walker B; other site 1032480011830 D-loop; other site 1032480011831 H-loop/switch region; other site 1032480011832 TOBE domain; Region: TOBE_2; cl01440 1032480011833 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 1032480011834 Helix-turn-helix domains; Region: HTH; cl00088 1032480011835 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480011836 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1032480011837 NAD(P) binding site [chemical binding]; other site 1032480011838 active site 1032480011839 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1032480011840 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1032480011841 G5 domain; Region: G5; pfam07501 1032480011842 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1032480011843 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 1032480011844 active site 1032480011845 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1032480011846 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1032480011847 Helix-turn-helix domains; Region: HTH; cl00088 1032480011848 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1032480011849 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1032480011850 active site 1032480011851 HIGH motif; other site 1032480011852 nucleotide binding site [chemical binding]; other site 1032480011853 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1032480011854 KMSKS motif; other site 1032480011855 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1032480011856 tRNA binding surface [nucleotide binding]; other site 1032480011857 anticodon binding site; other site 1032480011858 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1032480011859 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 1032480011860 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1032480011861 serine hydroxymethyltransferase; Provisional; Region: PRK13580 1032480011862 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1032480011863 dimer interface [polypeptide binding]; other site 1032480011864 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1032480011865 active site 1032480011866 folate binding site [chemical binding]; other site 1032480011867 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1032480011868 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1032480011869 Walker A/P-loop; other site 1032480011870 ATP binding site [chemical binding]; other site 1032480011871 Q-loop/lid; other site 1032480011872 ABC transporter signature motif; other site 1032480011873 Walker B; other site 1032480011874 D-loop; other site 1032480011875 H-loop/switch region; other site 1032480011876 Helix-turn-helix domains; Region: HTH; cl00088 1032480011877 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480011878 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480011879 active site 1032480011880 catalytic tetrad [active] 1032480011881 NMT1/THI5 like; Region: NMT1; pfam09084 1032480011882 NMT1-like family; Region: NMT1_2; cl15260 1032480011883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480011884 putative PBP binding loops; other site 1032480011885 dimer interface [polypeptide binding]; other site 1032480011886 ABC-ATPase subunit interface; other site 1032480011887 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 1032480011888 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1032480011889 Ligand Binding Site [chemical binding]; other site 1032480011890 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1032480011891 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 1032480011892 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1032480011893 homotrimer interaction site [polypeptide binding]; other site 1032480011894 CDP-binding sites; other site 1032480011895 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1032480011896 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1032480011897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480011898 active site 1032480011899 phosphorylation site [posttranslational modification] 1032480011900 intermolecular recognition site; other site 1032480011901 dimerization interface [polypeptide binding]; other site 1032480011902 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1032480011903 DNA binding site [nucleotide binding] 1032480011904 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1032480011905 dimer interface [polypeptide binding]; other site 1032480011906 phosphorylation site [posttranslational modification] 1032480011907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480011908 ATP binding site [chemical binding]; other site 1032480011909 Mg2+ binding site [ion binding]; other site 1032480011910 G-X-G motif; other site 1032480011911 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1032480011912 PhoU domain; Region: PhoU; pfam01895 1032480011913 PhoU domain; Region: PhoU; pfam01895 1032480011914 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480011915 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1032480011916 catalytic core [active] 1032480011917 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 1032480011918 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1032480011919 active site 1032480011920 catalytic site [active] 1032480011921 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1032480011922 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1032480011923 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1032480011924 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1032480011925 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1032480011926 G1 box; other site 1032480011927 GTP/Mg2+ binding site [chemical binding]; other site 1032480011928 G2 box; other site 1032480011929 Switch I region; other site 1032480011930 G3 box; other site 1032480011931 Switch II region; other site 1032480011932 G4 box; other site 1032480011933 Domain of unknown function (DUF697); Region: DUF697; cl12064 1032480011934 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 1032480011935 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480011936 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1032480011937 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 1032480011938 G1 box; other site 1032480011939 putative GEF interaction site [polypeptide binding]; other site 1032480011940 GTP/Mg2+ binding site [chemical binding]; other site 1032480011941 Switch I region; other site 1032480011942 G2 box; other site 1032480011943 G3 box; other site 1032480011944 Switch II region; other site 1032480011945 G4 box; other site 1032480011946 G5 box; other site 1032480011947 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1032480011948 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1032480011949 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480011950 non-specific DNA binding site [nucleotide binding]; other site 1032480011951 salt bridge; other site 1032480011952 sequence-specific DNA binding site [nucleotide binding]; other site 1032480011953 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1032480011954 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1032480011955 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1032480011956 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1032480011957 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480011958 motif II; other site 1032480011959 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480011960 L-asparaginase II; Region: Asparaginase_II; cl01842 1032480011961 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1032480011962 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1032480011963 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1032480011964 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1032480011965 heme-binding site [chemical binding]; other site 1032480011966 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480011967 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480011968 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1032480011969 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1032480011970 conserved cys residue [active] 1032480011971 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1032480011972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480011973 dimer interface [polypeptide binding]; other site 1032480011974 conserved gate region; other site 1032480011975 putative PBP binding loops; other site 1032480011976 ABC-ATPase subunit interface; other site 1032480011977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480011978 dimer interface [polypeptide binding]; other site 1032480011979 conserved gate region; other site 1032480011980 putative PBP binding loops; other site 1032480011981 ABC-ATPase subunit interface; other site 1032480011982 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1032480011983 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480011984 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480011985 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480011986 DNA binding site [nucleotide binding] 1032480011987 domain linker motif; other site 1032480011988 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480011989 dimerization interface [polypeptide binding]; other site 1032480011990 ligand binding site [chemical binding]; other site 1032480011991 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cl00253 1032480011992 putative active site [active] 1032480011993 dimerization interface [polypeptide binding]; other site 1032480011994 putative tRNAtyr binding site [nucleotide binding]; other site 1032480011995 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1032480011996 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1032480011997 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1032480011998 active site residue [active] 1032480011999 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1032480012000 active site residue [active] 1032480012001 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1032480012002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 1032480012003 active site 1032480012004 phosphorylation site [posttranslational modification] 1032480012005 intermolecular recognition site; other site 1032480012006 dimerization interface [polypeptide binding]; other site 1032480012007 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1032480012008 DNA binding site [nucleotide binding] 1032480012009 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1032480012010 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480012011 Coenzyme A binding pocket [chemical binding]; other site 1032480012012 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480012013 polyphosphate kinase; Provisional; Region: PRK05443 1032480012014 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1032480012015 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1032480012016 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1032480012017 putative domain interface [polypeptide binding]; other site 1032480012018 putative active site [active] 1032480012019 catalytic site [active] 1032480012020 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1032480012021 putative domain interface [polypeptide binding]; other site 1032480012022 putative active site [active] 1032480012023 catalytic site [active] 1032480012024 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1032480012025 active site 1032480012026 Ap6A binding site [chemical binding]; other site 1032480012027 nudix motif; other site 1032480012028 metal binding site [ion binding]; metal-binding site 1032480012029 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1032480012030 catalytic core [active] 1032480012031 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480012032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480012033 dimer interface [polypeptide binding]; other site 1032480012034 conserved gate region; other site 1032480012035 putative PBP binding loops; other site 1032480012036 ABC-ATPase subunit interface; other site 1032480012037 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1032480012038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480012039 dimer interface [polypeptide binding]; other site 1032480012040 conserved gate region; other site 1032480012041 putative PBP binding loops; other site 1032480012042 ABC-ATPase subunit interface; other site 1032480012043 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1032480012044 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 1032480012045 Walker A/P-loop; other site 1032480012046 ATP binding site [chemical binding]; other site 1032480012047 Q-loop/lid; other site 1032480012048 ABC transporter signature motif; other site 1032480012049 Walker B; other site 1032480012050 D-loop; other site 1032480012051 H-loop/switch region; other site 1032480012052 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1032480012053 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1032480012054 mycothione reductase; Reviewed; Region: PRK07846 1032480012055 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1032480012056 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1032480012057 Cysteine dioxygenase type I; Region: CDO_I; cl15835 1032480012058 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1032480012059 active site residue [active] 1032480012060 High-affinity nickel-transport protein; Region: NicO; cl00964 1032480012061 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480012062 dimerization interface [polypeptide binding]; other site 1032480012063 putative DNA binding site [nucleotide binding]; other site 1032480012064 putative Zn2+ binding site [ion binding]; other site 1032480012065 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1032480012066 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480012067 YCII-related domain; Region: YCII; cl00999 1032480012068 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1032480012069 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1032480012070 ResB-like family; Region: ResB; pfam05140 1032480012071 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1032480012072 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1032480012073 catalytic residues [active] 1032480012074 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1032480012075 catalytic core [active] 1032480012076 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1032480012077 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480012078 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480012079 catalytic residue [active] 1032480012080 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1032480012081 dimer interface [polypeptide binding]; other site 1032480012082 active site 1032480012083 Schiff base residues; other site 1032480012084 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1032480012085 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1032480012086 active site 1032480012087 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 1032480012088 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1032480012089 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 1032480012090 domain interfaces; other site 1032480012091 active site 1032480012092 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1032480012093 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1032480012094 tRNA; other site 1032480012095 putative tRNA binding site [nucleotide binding]; other site 1032480012096 putative NADP binding site [chemical binding]; other site 1032480012097 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1032480012098 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1032480012099 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1032480012100 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480012101 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 1032480012102 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1032480012103 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1032480012104 AMP-binding enzyme; Region: AMP-binding; cl15778 1032480012105 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1032480012106 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1032480012107 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1032480012108 putative acyl-acceptor binding pocket; other site 1032480012109 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1032480012110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480012111 NAD(P) binding site [chemical binding]; other site 1032480012112 active site 1032480012113 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1032480012114 Helix-turn-helix domains; Region: HTH; cl00088 1032480012115 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1032480012116 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 1032480012117 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 1032480012118 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1032480012119 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 1032480012120 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 1032480012121 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1032480012122 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1032480012123 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 1032480012124 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480012125 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1032480012126 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1032480012127 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480012128 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1032480012129 CAAX protease self-immunity; Region: Abi; cl00558 1032480012130 Proline dehydrogenase; Region: Pro_dh; cl03282 1032480012131 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1032480012132 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1032480012133 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1032480012134 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1032480012135 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480012136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480012137 homodimer interface [polypeptide binding]; other site 1032480012138 catalytic residue [active] 1032480012139 DNA repair protein RadA; Provisional; Region: PRK11823 1032480012140 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480012141 Walker A motif; other site 1032480012142 ATP binding site [chemical binding]; other site 1032480012143 Walker B motif; other site 1032480012144 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1032480012145 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1032480012146 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1032480012147 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1032480012148 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1032480012149 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1032480012150 endonuclease III; Region: ENDO3c; smart00478 1032480012151 minor groove reading motif; other site 1032480012152 helix-hairpin-helix signature motif; other site 1032480012153 substrate binding pocket [chemical binding]; other site 1032480012154 active site 1032480012155 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1032480012156 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480012157 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480012158 active site 1032480012159 catalytic tetrad [active] 1032480012160 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480012161 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480012162 Clp protease ATP binding subunit; Region: clpC; CHL00095 1032480012163 Clp amino terminal domain; Region: Clp_N; pfam02861 1032480012164 Clp amino terminal domain; Region: Clp_N; pfam02861 1032480012165 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480012166 Walker A motif; other site 1032480012167 ATP binding site [chemical binding]; other site 1032480012168 Walker B motif; other site 1032480012169 arginine finger; other site 1032480012170 UvrB/uvrC motif; Region: UVR; pfam02151 1032480012171 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480012172 Walker A motif; other site 1032480012173 ATP binding site [chemical binding]; other site 1032480012174 Walker B motif; other site 1032480012175 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1032480012176 Lsr2; Region: Lsr2; pfam11774 1032480012177 Helix-turn-helix domains; Region: HTH; cl00088 1032480012178 Zeta toxin; Region: Zeta_toxin; pfam06414 1032480012179 Helix-turn-helix domains; Region: HTH; cl00088 1032480012180 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1032480012181 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1032480012182 catalytic center binding site [active] 1032480012183 ATP binding site [chemical binding]; other site 1032480012184 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1032480012185 homooctamer interface [polypeptide binding]; other site 1032480012186 active site 1032480012187 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1032480012188 dihydropteroate synthase; Region: DHPS; TIGR01496 1032480012189 substrate binding pocket [chemical binding]; other site 1032480012190 dimer interface [polypeptide binding]; other site 1032480012191 inhibitor binding site; inhibition site 1032480012192 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1032480012193 homodecamer interface [polypeptide binding]; other site 1032480012194 GTP cyclohydrolase I; Provisional; Region: PLN03044 1032480012195 active site 1032480012196 putative catalytic site residues [active] 1032480012197 zinc binding site [ion binding]; other site 1032480012198 GTP-CH-I/GFRP interaction surface; other site 1032480012199 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1032480012200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480012201 Walker A motif; other site 1032480012202 ATP binding site [chemical binding]; other site 1032480012203 Walker B motif; other site 1032480012204 arginine finger; other site 1032480012205 Peptidase family M41; Region: Peptidase_M41; pfam01434 1032480012206 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1032480012207 active site 1032480012208 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1032480012209 Ligand Binding Site [chemical binding]; other site 1032480012210 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 1032480012211 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1032480012212 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1032480012213 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1032480012214 dimer interface [polypeptide binding]; other site 1032480012215 substrate binding site [chemical binding]; other site 1032480012216 metal binding sites [ion binding]; metal-binding site 1032480012217 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1032480012218 subtilisin-like protease; Provisional; Region: PTZ00262 1032480012219 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1032480012220 active site 1032480012221 catalytic residues [active] 1032480012222 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1032480012223 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1032480012224 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1032480012225 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480012226 Bacterial sugar transferase; Region: Bac_transf; cl00939 1032480012227 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1032480012228 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1032480012229 trimer interface [polypeptide binding]; other site 1032480012230 active site 1032480012231 substrate binding site [chemical binding]; other site 1032480012232 CoA binding site [chemical binding]; other site 1032480012233 O-Antigen ligase; Region: Wzy_C; cl04850 1032480012234 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1032480012235 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 1032480012236 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 1032480012237 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1032480012238 trimer interface [polypeptide binding]; other site 1032480012239 active site 1032480012240 substrate binding site [chemical binding]; other site 1032480012241 CoA binding site [chemical binding]; other site 1032480012242 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1032480012243 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1032480012244 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 1032480012245 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1032480012246 active site 1032480012247 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1032480012248 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1032480012249 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1032480012250 Probable Catalytic site; other site 1032480012251 metal-binding site 1032480012252 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480012253 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 1032480012254 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1032480012255 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1032480012256 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1032480012257 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1032480012258 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1032480012259 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 1032480012260 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 1032480012261 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1032480012262 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1032480012263 active site 1032480012264 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1032480012265 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480012266 Walker A/P-loop; other site 1032480012267 ATP binding site [chemical binding]; other site 1032480012268 Q-loop/lid; other site 1032480012269 ABC transporter signature motif; other site 1032480012270 Walker B; other site 1032480012271 D-loop; other site 1032480012272 H-loop/switch region; other site 1032480012273 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480012274 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1032480012275 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1032480012276 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1032480012277 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1032480012278 homodimer interface [polypeptide binding]; other site 1032480012279 NAD binding pocket [chemical binding]; other site 1032480012280 ATP binding pocket [chemical binding]; other site 1032480012281 Mg binding site [ion binding]; other site 1032480012282 active-site loop [active] 1032480012283 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1032480012284 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1032480012285 active site 1032480012286 dimer interface [polypeptide binding]; other site 1032480012287 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1032480012288 Ligand Binding Site [chemical binding]; other site 1032480012289 Molecular Tunnel; other site 1032480012290 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1032480012291 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1032480012292 AMP-binding enzyme; Region: AMP-binding; cl15778 1032480012293 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1032480012294 active site 1032480012295 catalytic triad [active] 1032480012296 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1032480012297 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1032480012298 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480012299 Walker A/P-loop; other site 1032480012300 ATP binding site [chemical binding]; other site 1032480012301 Q-loop/lid; other site 1032480012302 ABC transporter signature motif; other site 1032480012303 Walker B; other site 1032480012304 D-loop; other site 1032480012305 H-loop/switch region; other site 1032480012306 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1032480012307 active site 1032480012308 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 1032480012309 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1032480012310 Ligand Binding Site [chemical binding]; other site 1032480012311 Molecular Tunnel; other site 1032480012312 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1032480012313 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1032480012314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480012315 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1032480012316 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1032480012317 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1032480012318 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1032480012319 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1032480012320 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1032480012321 putative active site [active] 1032480012322 putative metal binding site [ion binding]; other site 1032480012323 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1032480012324 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1032480012325 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1032480012326 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1032480012327 active site 1032480012328 catalytic residues [active] 1032480012329 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1032480012330 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480012331 Bacterial sugar transferase; Region: Bac_transf; cl00939 1032480012332 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 1032480012333 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1032480012334 CysD dimerization site [polypeptide binding]; other site 1032480012335 G1 box; other site 1032480012336 putative GEF interaction site [polypeptide binding]; other site 1032480012337 GTP/Mg2+ binding site [chemical binding]; other site 1032480012338 Switch I region; other site 1032480012339 G2 box; other site 1032480012340 G3 box; other site 1032480012341 Switch II region; other site 1032480012342 G4 box; other site 1032480012343 G5 box; other site 1032480012344 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1032480012345 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1032480012346 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1032480012347 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1032480012348 Active Sites [active] 1032480012349 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1032480012350 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480012351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480012352 metabolite-proton symporter; Region: 2A0106; TIGR00883 1032480012353 putative substrate translocation pore; other site 1032480012354 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1032480012355 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480012356 S-adenosylmethionine binding site [chemical binding]; other site 1032480012357 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1032480012358 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1032480012359 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1032480012360 MoxR-like ATPases [General function prediction only]; Region: COG0714 1032480012361 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480012362 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1032480012363 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1032480012364 AAA domain; Region: AAA_33; pfam13671 1032480012365 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 1032480012366 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1032480012367 LysE type translocator; Region: LysE; cl00565 1032480012368 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1032480012369 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480012370 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1032480012371 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 1032480012372 putative active site [active] 1032480012373 putative NTP binding site [chemical binding]; other site 1032480012374 putative nucleic acid binding site [nucleotide binding]; other site 1032480012375 Helix-turn-helix domains; Region: HTH; cl00088 1032480012376 putative transposase OrfB; Reviewed; Region: PHA02517 1032480012377 HTH-like domain; Region: HTH_21; pfam13276 1032480012378 Integrase core domain; Region: rve; cl01316 1032480012379 Integrase core domain; Region: rve_3; cl15866 1032480012380 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1032480012381 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480012382 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1032480012383 synthetase active site [active] 1032480012384 NTP binding site [chemical binding]; other site 1032480012385 metal binding site [ion binding]; metal-binding site 1032480012386 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cl10030 1032480012387 homotrimer interaction site [polypeptide binding]; other site 1032480012388 zinc binding site [ion binding]; other site 1032480012389 CDP-binding sites; other site 1032480012390 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480012391 non-specific DNA binding site [nucleotide binding]; other site 1032480012392 salt bridge; other site 1032480012393 sequence-specific DNA binding site [nucleotide binding]; other site 1032480012394 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1032480012395 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480012396 motif II; other site 1032480012397 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1032480012398 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1032480012399 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480012400 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1032480012401 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1032480012402 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1032480012403 Int/Topo IB signature motif; other site 1032480012404 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1032480012405 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480012406 non-specific DNA binding site [nucleotide binding]; other site 1032480012407 salt bridge; other site 1032480012408 sequence-specific DNA binding site [nucleotide binding]; other site 1032480012409 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 1032480012410 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1032480012411 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480012412 motif II; other site 1032480012413 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1032480012414 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480012415 DNA-binding site [nucleotide binding]; DNA binding site 1032480012416 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1032480012417 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480012418 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1032480012419 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1032480012420 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1032480012421 DNA binding site [nucleotide binding] 1032480012422 Int/Topo IB signature motif; other site 1032480012423 active site 1032480012424 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1032480012425 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480012426 PSP1 C-terminal conserved region; Region: PSP1; cl00770 1032480012427 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1032480012428 Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374 1032480012429 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480012430 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1032480012431 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1032480012432 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480012433 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1032480012434 thymidylate kinase; Validated; Region: tmk; PRK00698 1032480012435 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1032480012436 TMP-binding site; other site 1032480012437 ATP-binding site [chemical binding]; other site 1032480012438 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1032480012439 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1032480012440 active site 1032480012441 interdomain interaction site; other site 1032480012442 putative metal-binding site [ion binding]; other site 1032480012443 nucleotide binding site [chemical binding]; other site 1032480012444 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 1032480012445 domain I; other site 1032480012446 phosphate binding site [ion binding]; other site 1032480012447 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1032480012448 domain II; other site 1032480012449 domain III; other site 1032480012450 nucleotide binding site [chemical binding]; other site 1032480012451 DNA binding groove [nucleotide binding] 1032480012452 catalytic site [active] 1032480012453 domain IV; other site 1032480012454 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1032480012455 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1032480012456 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1032480012457 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1032480012458 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480012459 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1032480012460 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1032480012461 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1032480012462 intersubunit interface [polypeptide binding]; other site 1032480012463 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1032480012464 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1032480012465 Walker A/P-loop; other site 1032480012466 ATP binding site [chemical binding]; other site 1032480012467 Q-loop/lid; other site 1032480012468 ABC transporter signature motif; other site 1032480012469 Walker B; other site 1032480012470 D-loop; other site 1032480012471 H-loop/switch region; other site 1032480012472 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1032480012473 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1032480012474 ABC-ATPase subunit interface; other site 1032480012475 dimer interface [polypeptide binding]; other site 1032480012476 putative PBP binding regions; other site 1032480012477 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1032480012478 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1032480012479 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1032480012480 ABC-ATPase subunit interface; other site 1032480012481 dimer interface [polypeptide binding]; other site 1032480012482 putative PBP binding regions; other site 1032480012483 CAAX protease self-immunity; Region: Abi; cl00558 1032480012484 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 1032480012485 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 1032480012486 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1032480012487 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480012488 putative Mg++ binding site [ion binding]; other site 1032480012489 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480012490 nucleotide binding region [chemical binding]; other site 1032480012491 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 1032480012492 Helix-turn-helix domain; Region: HTH_18; pfam12833 1032480012493 Helix-turn-helix domain; Region: HTH_18; pfam12833 1032480012494 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480012495 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1032480012496 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1032480012497 homodimer interface [polypeptide binding]; other site 1032480012498 active site 1032480012499 TDP-binding site; other site 1032480012500 acceptor substrate-binding pocket; other site 1032480012501 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 1032480012502 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1032480012503 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 1032480012504 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1032480012505 ATP binding site [chemical binding]; other site 1032480012506 Walker A motif; other site 1032480012507 hexamer interface [polypeptide binding]; other site 1032480012508 Walker B motif; other site 1032480012509 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1032480012510 Fic family protein [Function unknown]; Region: COG3177 1032480012511 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480012512 S-adenosylmethionine binding site [chemical binding]; other site 1032480012513 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1032480012514 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1032480012515 dimer interface [polypeptide binding]; other site 1032480012516 active site 1032480012517 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1032480012518 dimer interface [polypeptide binding]; other site 1032480012519 active site 1032480012520 Helix-turn-helix domains; Region: HTH; cl00088 1032480012521 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1032480012522 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1032480012523 active site 1032480012524 TDP-binding site; other site 1032480012525 acceptor substrate-binding pocket; other site 1032480012526 acetyl-CoA synthetase; Provisional; Region: PRK00174 1032480012527 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1032480012528 AMP-binding enzyme; Region: AMP-binding; cl15778 1032480012529 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480012530 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1032480012531 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480012532 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480012533 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480012534 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1032480012535 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1032480012536 Ca binding site [ion binding]; other site 1032480012537 active site 1032480012538 catalytic site [active] 1032480012539 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1032480012540 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1032480012541 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1032480012542 putative active site [active] 1032480012543 putative CoA binding site [chemical binding]; other site 1032480012544 nudix motif; other site 1032480012545 metal binding site [ion binding]; metal-binding site 1032480012546 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1032480012547 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1032480012548 minor groove reading motif; other site 1032480012549 helix-hairpin-helix signature motif; other site 1032480012550 substrate binding pocket [chemical binding]; other site 1032480012551 active site 1032480012552 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1032480012553 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1032480012554 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1032480012555 ligand binding site [chemical binding]; other site 1032480012556 flexible hinge region; other site 1032480012557 Helix-turn-helix domains; Region: HTH; cl00088 1032480012558 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1032480012559 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1032480012560 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1032480012561 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1032480012562 nudix motif; other site 1032480012563 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1032480012564 homotrimer interaction site [polypeptide binding]; other site 1032480012565 putative active site [active] 1032480012566 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1032480012567 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1032480012568 HTH-like domain; Region: HTH_21; pfam13276 1032480012569 Integrase core domain; Region: rve; cl01316 1032480012570 Integrase core domain; Region: rve_3; cl15866 1032480012571 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1032480012572 Helix-turn-helix domains; Region: HTH; cl00088 1032480012573 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1032480012574 active site 1032480012575 metal binding site [ion binding]; metal-binding site 1032480012576 Helix-turn-helix domains; Region: HTH; cl00088 1032480012577 putative transposase OrfB; Reviewed; Region: PHA02517 1032480012578 HTH-like domain; Region: HTH_21; pfam13276 1032480012579 Integrase core domain; Region: rve; cl01316 1032480012580 Integrase core domain; Region: rve_3; cl15866 1032480012581 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480012582 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1032480012583 P loop; other site 1032480012584 Nucleotide binding site [chemical binding]; other site 1032480012585 DTAP/Switch II; other site 1032480012586 Switch I; other site 1032480012587 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1032480012588 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1032480012589 P loop; other site 1032480012590 Nucleotide binding site [chemical binding]; other site 1032480012591 DTAP/Switch II; other site 1032480012592 Switch I; other site 1032480012593 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1032480012594 Transcription factor WhiB; Region: Whib; pfam02467 1032480012595 Transglycosylase; Region: Transgly; cl07896 1032480012596 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1032480012597 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1032480012598 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 1032480012599 GatB domain; Region: GatB_Yqey; cl11497 1032480012600 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1032480012601 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1032480012602 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1032480012603 putative active site [active] 1032480012604 putative metal binding site [ion binding]; other site 1032480012605 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1032480012606 potential frameshift: common BLAST hit: gi|229819264|ref|YP_002880790.1| conserved repeat domain protein 1032480012607 Fibronectin type III-like domain; Region: Fn3-like; cl15273 1032480012608 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1032480012609 Sulfatase; Region: Sulfatase; cl10460 1032480012610 aspartate kinase; Reviewed; Region: PRK06635 1032480012611 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1032480012612 putative nucleotide binding site [chemical binding]; other site 1032480012613 putative catalytic residues [active] 1032480012614 putative Mg ion binding site [ion binding]; other site 1032480012615 putative aspartate binding site [chemical binding]; other site 1032480012616 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1032480012617 putative allosteric regulatory site; other site 1032480012618 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1032480012619 putative allosteric regulatory residue; other site 1032480012620 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1032480012621 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1032480012622 siderophore binding site; other site 1032480012623 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1032480012624 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1032480012625 siderophore binding site; other site 1032480012626 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1032480012627 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480012628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480012629 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1032480012630 recombination protein RecR; Reviewed; Region: recR; PRK00076 1032480012631 RecR protein; Region: RecR; pfam02132 1032480012632 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1032480012633 putative active site [active] 1032480012634 putative metal-binding site [ion binding]; other site 1032480012635 tetramer interface [polypeptide binding]; other site 1032480012636 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 1032480012637 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 1032480012638 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480012639 Walker A motif; other site 1032480012640 ATP binding site [chemical binding]; other site 1032480012641 Walker B motif; other site 1032480012642 arginine finger; other site 1032480012643 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 1032480012644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480012645 putative substrate translocation pore; other site 1032480012646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480012647 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1032480012648 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1032480012649 Protein of unknown function DUF72; Region: DUF72; cl00777 1032480012650 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480012651 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480012652 active site 1032480012653 substrate binding site [chemical binding]; other site 1032480012654 ATP binding site [chemical binding]; other site 1032480012655 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1032480012656 Protein of unknown function (DUF433); Region: DUF433; cl01030 1032480012657 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1032480012658 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1032480012659 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480012660 ATP binding site [chemical binding]; other site 1032480012661 putative Mg++ binding site [ion binding]; other site 1032480012662 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480012663 Fic/DOC family; Region: Fic; cl00960 1032480012664 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1032480012665 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480012666 Walker A/P-loop; other site 1032480012667 ATP binding site [chemical binding]; other site 1032480012668 Q-loop/lid; other site 1032480012669 ABC transporter signature motif; other site 1032480012670 Walker B; other site 1032480012671 D-loop; other site 1032480012672 H-loop/switch region; other site 1032480012673 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 1032480012674 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1032480012675 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480012676 Walker A/P-loop; other site 1032480012677 ATP binding site [chemical binding]; other site 1032480012678 Q-loop/lid; other site 1032480012679 ABC transporter signature motif; other site 1032480012680 Walker B; other site 1032480012681 D-loop; other site 1032480012682 H-loop/switch region; other site 1032480012683 Uncharacterized conserved protein [Function unknown]; Region: COG1944; cl09146 1032480012684 YcaO-like family; Region: YcaO; pfam02624 1032480012685 Uncharacterized conserved protein [Function unknown]; Region: COG1944; cl09146 1032480012686 YcaO-like family; Region: YcaO; pfam02624 1032480012687 Uncharacterized conserved protein [Function unknown]; Region: COG1944; cl09146 1032480012688 YcaO-like family; Region: YcaO; pfam02624 1032480012689 TfuA-like protein; Region: TfuA; pfam07812 1032480012690 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1032480012691 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480012692 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1032480012693 MatE; Region: MatE; cl10513 1032480012694 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1032480012695 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1032480012696 intersubunit interface [polypeptide binding]; other site 1032480012697 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1032480012698 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1032480012699 Walker A/P-loop; other site 1032480012700 ATP binding site [chemical binding]; other site 1032480012701 Q-loop/lid; other site 1032480012702 ABC transporter signature motif; other site 1032480012703 Walker B; other site 1032480012704 D-loop; other site 1032480012705 H-loop/switch region; other site 1032480012706 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1032480012707 dimer interface [polypeptide binding]; other site 1032480012708 putative PBP binding regions; other site 1032480012709 ABC-ATPase subunit interface; other site 1032480012710 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1032480012711 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1032480012712 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1032480012713 putative active site [active] 1032480012714 catalytic site [active] 1032480012715 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 1032480012716 putative active site [active] 1032480012717 catalytic site [active] 1032480012718 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1032480012719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 1032480012720 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480012721 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1032480012722 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1032480012723 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1032480012724 putative catalytic site [active] 1032480012725 putative metal binding site [ion binding]; other site 1032480012726 putative phosphate binding site [ion binding]; other site 1032480012727 NlpC/P60 family; Region: NLPC_P60; cl11438 1032480012728 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1032480012729 hypothetical protein; Provisional; Region: PRK06753 1032480012730 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480012731 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 1032480012732 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1032480012733 Glutamate binding site [chemical binding]; other site 1032480012734 NAD binding site [chemical binding]; other site 1032480012735 catalytic residues [active] 1032480012736 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1032480012737 Helix-turn-helix domains; Region: HTH; cl00088 1032480012738 Proline dehydrogenase; Region: Pro_dh; cl03282 1032480012739 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1032480012740 Active site serine [active] 1032480012741 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1032480012742 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 1032480012743 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1032480012744 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1032480012745 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1032480012746 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1032480012747 nucleoside/Zn binding site; other site 1032480012748 dimer interface [polypeptide binding]; other site 1032480012749 catalytic motif [active] 1032480012750 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1032480012751 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1032480012752 active site 1032480012753 Putative addiction module component; Region: Unstab_antitox; cl09921 1032480012754 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1032480012755 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1032480012756 substrate binding site [chemical binding]; other site 1032480012757 oxyanion hole (OAH) forming residues; other site 1032480012758 trimer interface [polypeptide binding]; other site 1032480012759 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1032480012760 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480012761 non-specific DNA binding site [nucleotide binding]; other site 1032480012762 salt bridge; other site 1032480012763 sequence-specific DNA binding site [nucleotide binding]; other site 1032480012764 Predicted ATPase [General function prediction only]; Region: COG3903 1032480012765 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1032480012766 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1032480012767 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1032480012768 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1032480012769 active site 1032480012770 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1032480012771 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1032480012772 nucleotide binding site/active site [active] 1032480012773 HIT family signature motif; other site 1032480012774 catalytic residue [active] 1032480012775 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480012776 ATP binding site [chemical binding]; other site 1032480012777 putative Mg++ binding site [ion binding]; other site 1032480012778 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480012779 nucleotide binding region [chemical binding]; other site 1032480012780 ATP-binding site [chemical binding]; other site 1032480012781 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1032480012782 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1032480012783 classical (c) SDRs; Region: SDR_c; cd05233 1032480012784 NAD(P) binding site [chemical binding]; other site 1032480012785 active site 1032480012786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480012787 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1032480012788 putative substrate translocation pore; other site 1032480012789 CAAX protease self-immunity; Region: Abi; cl00558 1032480012790 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1032480012791 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1032480012792 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 1032480012793 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1032480012794 active site 1032480012795 haloalkane dehalogenase; Provisional; Region: PRK03592 1032480012796 peptide synthase; Provisional; Region: PRK09274 1032480012797 AMP-binding enzyme; Region: AMP-binding; cl15778 1032480012798 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480012799 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1032480012800 NAD(P) binding site [chemical binding]; other site 1032480012801 active site 1032480012802 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1032480012803 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480012804 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 1032480012805 cyclase homology domain; Region: CHD; cd07302 1032480012806 nucleotidyl binding site; other site 1032480012807 metal binding site [ion binding]; metal-binding site 1032480012808 dimer interface [polypeptide binding]; other site 1032480012809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480012810 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1032480012811 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1032480012812 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1032480012813 substrate binding pocket [chemical binding]; other site 1032480012814 chain length determination region; other site 1032480012815 substrate-Mg2+ binding site; other site 1032480012816 catalytic residues [active] 1032480012817 aspartate-rich region 1; other site 1032480012818 active site lid residues [active] 1032480012819 aspartate-rich region 2; other site 1032480012820 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1032480012821 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1032480012822 ligand binding site [chemical binding]; other site 1032480012823 flexible hinge region; other site 1032480012824 Helix-turn-helix domains; Region: HTH; cl00088 1032480012825 Phosphate transporter family; Region: PHO4; cl00396 1032480012826 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1032480012827 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1032480012828 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1032480012829 NAD(P) binding site [chemical binding]; other site 1032480012830 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480012831 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1032480012832 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1032480012833 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1032480012834 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480012835 Walker A/P-loop; other site 1032480012836 ATP binding site [chemical binding]; other site 1032480012837 Q-loop/lid; other site 1032480012838 ABC transporter signature motif; other site 1032480012839 Walker B; other site 1032480012840 D-loop; other site 1032480012841 H-loop/switch region; other site 1032480012842 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1032480012843 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480012844 Q-loop/lid; other site 1032480012845 ABC transporter signature motif; other site 1032480012846 Walker B; other site 1032480012847 D-loop; other site 1032480012848 H-loop/switch region; other site 1032480012849 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 1032480012850 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480012851 seryl-tRNA synthetase; Provisional; Region: PRK05431 1032480012852 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1032480012853 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 1032480012854 dimer interface [polypeptide binding]; other site 1032480012855 active site 1032480012856 motif 1; other site 1032480012857 motif 2; other site 1032480012858 motif 3; other site 1032480012859 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1032480012860 active site 1032480012861 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1032480012862 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1032480012863 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1032480012864 Cation efflux family; Region: Cation_efflux; cl00316 1032480012865 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480012866 dimerization interface [polypeptide binding]; other site 1032480012867 putative DNA binding site [nucleotide binding]; other site 1032480012868 putative Zn2+ binding site [ion binding]; other site 1032480012869 RES domain; Region: RES; cl02411 1032480012870 replicative DNA helicase; Region: DnaB; TIGR00665 1032480012871 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1032480012872 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1032480012873 Walker A motif; other site 1032480012874 ATP binding site [chemical binding]; other site 1032480012875 Walker B motif; other site 1032480012876 DNA binding loops [nucleotide binding] 1032480012877 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1032480012878 putative homotetramer interface [polypeptide binding]; other site 1032480012879 putative homodimer interface [polypeptide binding]; other site 1032480012880 putative allosteric switch controlling residues; other site 1032480012881 putative metal binding site [ion binding]; other site 1032480012882 putative homodimer-homodimer interface [polypeptide binding]; other site 1032480012883 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1032480012884 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1032480012885 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1032480012886 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1032480012887 DNA binding residues [nucleotide binding] 1032480012888 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480012889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480012890 active site 1032480012891 phosphorylation site [posttranslational modification] 1032480012892 intermolecular recognition site; other site 1032480012893 dimerization interface [polypeptide binding]; other site 1032480012894 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480012895 DNA binding residues [nucleotide binding] 1032480012896 dimerization interface [polypeptide binding]; other site 1032480012897 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1032480012898 Histidine kinase; Region: HisKA_3; pfam07730 1032480012899 CAAX protease self-immunity; Region: Abi; cl00558 1032480012900 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1032480012901 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1032480012902 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1032480012903 active site 1032480012904 catalytic site [active] 1032480012905 Sodium:solute symporter family; Region: SSF; cl00456 1032480012906 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1032480012907 active site residue [active] 1032480012908 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1032480012909 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 1032480012910 putative DNA binding site [nucleotide binding]; other site 1032480012911 catalytic residue [active] 1032480012912 putative H2TH interface [polypeptide binding]; other site 1032480012913 putative catalytic residues [active] 1032480012914 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1032480012915 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1032480012916 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480012917 non-specific DNA binding site [nucleotide binding]; other site 1032480012918 salt bridge; other site 1032480012919 sequence-specific DNA binding site [nucleotide binding]; other site 1032480012920 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1032480012921 putative peptidoglycan binding site; other site 1032480012922 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1032480012923 putative peptidoglycan binding site; other site 1032480012924 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 1032480012925 Bacterial transcriptional activator domain; Region: BTAD; smart01043 1032480012926 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1032480012927 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480012928 Walker A motif; other site 1032480012929 ATP binding site [chemical binding]; other site 1032480012930 Walker B motif; other site 1032480012931 SAF domain; Region: SAF; cl00555 1032480012932 dolichyl-phosphate beta-glucosyltransferase; Provisional; Region: PTZ00260 1032480012933 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1032480012934 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480012935 EcsC protein family; Region: EcsC; pfam12787 1032480012936 Iron permease FTR1 family; Region: FTR1; cl00475 1032480012937 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1032480012938 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1032480012939 Imelysin; Region: Peptidase_M75; cl09159 1032480012940 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1032480012941 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1032480012942 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 1032480012943 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 1032480012944 active site 1032480012945 catalytic triad [active] 1032480012946 oxyanion hole [active] 1032480012947 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 1032480012948 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1032480012949 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1032480012950 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1032480012951 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1032480012952 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1032480012953 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1032480012954 substrate-cofactor binding pocket; other site 1032480012955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480012956 catalytic residue [active] 1032480012957 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1032480012958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480012959 NAD(P) binding site [chemical binding]; other site 1032480012960 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1032480012961 Helix-turn-helix domains; Region: HTH; cl00088 1032480012962 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480012963 dimerization interface [polypeptide binding]; other site 1032480012964 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1032480012965 TIR domain; Region: TIR_2; cl15770 1032480012966 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 1032480012967 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 1032480012968 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1032480012969 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480012970 DNA binding residues [nucleotide binding] 1032480012971 dimerization interface [polypeptide binding]; other site 1032480012972 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 1032480012973 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12724 1032480012974 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480012975 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1032480012976 Protein of unknown function (DUF433); Region: DUF433; cl01030 1032480012977 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480012978 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1032480012979 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480012980 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1032480012981 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1032480012982 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480012983 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1032480012984 Abortive infection C-terminus; Region: Abi_C; pfam14355 1032480012985 Helix-turn-helix domains; Region: HTH; cl00088 1032480012986 HTH-like domain; Region: HTH_21; pfam13276 1032480012987 Integrase core domain; Region: rve; cl01316 1032480012988 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1032480012989 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1032480012990 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1032480012991 DNA binding site [nucleotide binding] 1032480012992 Int/Topo IB signature motif; other site 1032480012993 active site 1032480012994 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1032480012995 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1032480012996 DNA binding site [nucleotide binding] 1032480012997 Int/Topo IB signature motif; other site 1032480012998 active site 1032480012999 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1032480013000 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1032480013001 Int/Topo IB signature motif; other site 1032480013002 active site 1032480013003 DNA binding site [nucleotide binding] 1032480013004 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480013005 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480013006 DNA binding site [nucleotide binding] 1032480013007 domain linker motif; other site 1032480013008 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480013009 dimerization interface [polypeptide binding]; other site 1032480013010 ligand binding site [chemical binding]; other site 1032480013011 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1032480013012 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480013013 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1032480013014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480013015 dimer interface [polypeptide binding]; other site 1032480013016 conserved gate region; other site 1032480013017 putative PBP binding loops; other site 1032480013018 ABC-ATPase subunit interface; other site 1032480013019 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1032480013020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480013021 dimer interface [polypeptide binding]; other site 1032480013022 conserved gate region; other site 1032480013023 ABC-ATPase subunit interface; other site 1032480013024 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 1032480013025 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 1032480013026 Fibronectin type III-like domain; Region: Fn3-like; cl15273 1032480013027 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 1032480013028 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1032480013029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480013030 Walker A motif; other site 1032480013031 ATP binding site [chemical binding]; other site 1032480013032 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1032480013033 Integrase core domain; Region: rve; cl01316 1032480013034 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1032480013035 formyl-coenzyme A transferase; Provisional; Region: PRK05398 1032480013036 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1032480013037 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 1032480013038 active site 1032480013039 citrylCoA binding site [chemical binding]; other site 1032480013040 oxalacetate binding site [chemical binding]; other site 1032480013041 coenzyme A binding site [chemical binding]; other site 1032480013042 catalytic triad [active] 1032480013043 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480013044 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1032480013045 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1032480013046 putative NAD(P) binding site [chemical binding]; other site 1032480013047 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480013048 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480013049 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480013050 Helix-turn-helix domains; Region: HTH; cl00088 1032480013051 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1032480013052 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1032480013053 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1032480013054 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1032480013055 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480013056 dimerization interface [polypeptide binding]; other site 1032480013057 putative DNA binding site [nucleotide binding]; other site 1032480013058 putative Zn2+ binding site [ion binding]; other site 1032480013059 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1032480013060 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1032480013061 ResB-like family; Region: ResB; pfam05140 1032480013062 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1032480013063 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1032480013064 putative active site [active] 1032480013065 catalytic triad [active] 1032480013066 putative dimer interface [polypeptide binding]; other site 1032480013067 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1032480013068 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1032480013069 catalytic residues [active] 1032480013070 Vitamin K epoxide reductase family; Region: VKOR; cl01729 1032480013071 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1032480013072 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1032480013073 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480013074 dimerization interface [polypeptide binding]; other site 1032480013075 putative DNA binding site [nucleotide binding]; other site 1032480013076 putative Zn2+ binding site [ion binding]; other site 1032480013077 Phospholipid methyltransferase; Region: PEMT; cl00763 1032480013078 Cation efflux family; Region: Cation_efflux; cl00316 1032480013079 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1032480013080 CAAX protease self-immunity; Region: Abi; cl00558 1032480013081 Bacterial Ig-like domain; Region: Big_5; cl01012 1032480013082 Copper resistance protein D; Region: CopD; cl00563 1032480013083 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 1032480013084 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1032480013085 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480013086 putative DNA binding site [nucleotide binding]; other site 1032480013087 putative Zn2+ binding site [ion binding]; other site 1032480013088 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1032480013089 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1032480013090 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1032480013091 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480013092 dimerization interface [polypeptide binding]; other site 1032480013093 putative DNA binding site [nucleotide binding]; other site 1032480013094 putative Zn2+ binding site [ion binding]; other site 1032480013095 Cation efflux family; Region: Cation_efflux; cl00316 1032480013096 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480013097 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1032480013098 minor groove reading motif; other site 1032480013099 helix-hairpin-helix signature motif; other site 1032480013100 active site 1032480013101 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1032480013102 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1032480013103 ATP binding site [chemical binding]; other site 1032480013104 substrate binding site [chemical binding]; other site 1032480013105 TIR domain; Region: TIR_2; cl15770 1032480013106 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1032480013107 Ligand Binding Site [chemical binding]; other site 1032480013108 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 1032480013109 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1032480013110 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1032480013111 Zn2+ binding site [ion binding]; other site 1032480013112 Mg2+ binding site [ion binding]; other site 1032480013113 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1032480013114 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480013115 non-specific DNA binding site [nucleotide binding]; other site 1032480013116 salt bridge; other site 1032480013117 sequence-specific DNA binding site [nucleotide binding]; other site 1032480013118 Domain of unknown function (DUF955); Region: DUF955; cl01076 1032480013119 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480013120 non-specific DNA binding site [nucleotide binding]; other site 1032480013121 salt bridge; other site 1032480013122 sequence-specific DNA binding site [nucleotide binding]; other site 1032480013123 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1032480013124 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1032480013125 phosphopeptide binding site; other site 1032480013126 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1032480013127 phosphopeptide binding site; other site 1032480013128 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1032480013129 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1032480013130 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1032480013131 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1032480013132 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1032480013133 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480013134 active site 1032480013135 ATP binding site [chemical binding]; other site 1032480013136 substrate binding site [chemical binding]; other site 1032480013137 activation loop (A-loop); other site 1032480013138 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1032480013139 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1032480013140 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1032480013141 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1032480013142 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480013143 hypothetical protein; Provisional; Region: PRK07524 1032480013144 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1032480013145 PYR/PP interface [polypeptide binding]; other site 1032480013146 dimer interface [polypeptide binding]; other site 1032480013147 TPP binding site [chemical binding]; other site 1032480013148 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1032480013149 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1032480013150 TPP-binding site [chemical binding]; other site 1032480013151 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1032480013152 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1032480013153 active site 1032480013154 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1032480013155 Helix-turn-helix domains; Region: HTH; cl00088 1032480013156 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1032480013157 Helix-turn-helix domains; Region: HTH; cl00088 1032480013158 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1032480013159 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1032480013160 glutamine binding [chemical binding]; other site 1032480013161 catalytic triad [active] 1032480013162 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1032480013163 Uncharacterized protein family (UPF0233); Region: UPF0233; cl11506 1032480013164 MatE; Region: MatE; cl10513 1032480013165 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1032480013166 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1032480013167 Ion channel; Region: Ion_trans_2; cl11596 1032480013168 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1032480013169 active site 1032480013170 metal binding site [ion binding]; metal-binding site 1032480013171 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1032480013172 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1032480013173 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 1032480013174 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1032480013175 dimer interface [polypeptide binding]; other site 1032480013176 ssDNA binding site [nucleotide binding]; other site 1032480013177 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1032480013178 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 1032480013179 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1032480013180 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1032480013181 Putative esterase; Region: Esterase; pfam00756 1032480013182 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1032480013183 Peptidase family M48; Region: Peptidase_M48; cl12018 1032480013184 endonuclease IV; Provisional; Region: PRK01060 1032480013185 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1032480013186 AP (apurinic/apyrimidinic) site pocket; other site 1032480013187 DNA interaction; other site 1032480013188 Metal-binding active site; metal-binding site 1032480013189 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1032480013190 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1032480013191 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 1032480013192 Walker A/P-loop; other site 1032480013193 ATP binding site [chemical binding]; other site 1032480013194 Q-loop/lid; other site 1032480013195 ABC transporter signature motif; other site 1032480013196 Walker B; other site 1032480013197 D-loop; other site 1032480013198 H-loop/switch region; other site 1032480013199 Protein of unknown function (DUF419); Region: DUF419; cl15265 1032480013200 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1032480013201 H+ Antiporter protein; Region: 2A0121; TIGR00900 1032480013202 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1032480013203 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1032480013204 active site 1032480013205 NTP binding site [chemical binding]; other site 1032480013206 metal binding triad [ion binding]; metal-binding site 1032480013207 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1032480013208 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1032480013209 Zn2+ binding site [ion binding]; other site 1032480013210 Mg2+ binding site [ion binding]; other site 1032480013211 MviN-like protein; Region: MVIN; pfam03023 1032480013212 MatE; Region: MatE; cl10513 1032480013213 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480013214 ATP binding site [chemical binding]; other site 1032480013215 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 1032480013216 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480013217 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 1032480013218 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1032480013219 DNA binding residues [nucleotide binding] 1032480013220 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480013221 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1032480013222 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1032480013223 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1032480013224 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1032480013225 catalytic residues [active] 1032480013226 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1032480013227 hypothetical protein; Provisional; Region: PRK08296 1032480013228 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1032480013229 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1032480013230 Helix-turn-helix domains; Region: HTH; cl00088 1032480013231 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480013232 non-specific DNA binding site [nucleotide binding]; other site 1032480013233 salt bridge; other site 1032480013234 sequence-specific DNA binding site [nucleotide binding]; other site 1032480013235 hypothetical protein; Provisional; Region: PRK01346 1032480013236 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480013237 OsmC-like protein; Region: OsmC; cl00767 1032480013238 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1032480013239 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1032480013240 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480013241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480013242 homodimer interface [polypeptide binding]; other site 1032480013243 catalytic residue [active] 1032480013244 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1032480013245 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1032480013246 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1032480013247 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1032480013248 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1032480013249 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1032480013250 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1032480013251 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480013252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480013253 active site 1032480013254 phosphorylation site [posttranslational modification] 1032480013255 intermolecular recognition site; other site 1032480013256 dimerization interface [polypeptide binding]; other site 1032480013257 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480013258 DNA binding residues [nucleotide binding] 1032480013259 dimerization interface [polypeptide binding]; other site 1032480013260 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1032480013261 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1032480013262 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1032480013263 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1032480013264 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1032480013265 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 1032480013266 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1032480013267 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1032480013268 FAD binding pocket [chemical binding]; other site 1032480013269 FAD binding motif [chemical binding]; other site 1032480013270 phosphate binding motif [ion binding]; other site 1032480013271 NAD binding pocket [chemical binding]; other site 1032480013272 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1032480013273 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1032480013274 PYR/PP interface [polypeptide binding]; other site 1032480013275 dimer interface [polypeptide binding]; other site 1032480013276 TPP binding site [chemical binding]; other site 1032480013277 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1032480013278 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1032480013279 TPP-binding site [chemical binding]; other site 1032480013280 Putative cyclase; Region: Cyclase; cl00814 1032480013281 ParB-like partition proteins; Region: parB_part; TIGR00180 1032480013282 ParB-like nuclease domain; Region: ParBc; cl02129 1032480013283 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1032480013284 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1032480013285 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1032480013286 Magnesium ion binding site [ion binding]; other site 1032480013287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 1032480013288 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1032480013289 G-X-X-G motif; other site 1032480013290 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1032480013291 RxxxH motif; other site 1032480013292 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 1032480013293 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1032480013294 Haemolytic domain; Region: Haemolytic; cl00506 1032480013295 Ribonuclease P; Region: Ribonuclease_P; cl00457